Podcasts about PFS

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Best podcasts about PFS

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Latest podcast episodes about PFS

Financial Sense(R) Newshour
The $9.5 Trillion Refinancing Shock: Are You Prepared for the Yield Spike?

Financial Sense(R) Newshour

Play Episode Listen Later Sep 19, 2026 28:44


Sep 18, 2026 – Financial Sense Wealth Management's Jim Puplava examines the dramatic rise in interest rates and the “refinancing shock” facing the US, as trillions in government debt must be renewed at significantly higher yields. He explores how...

Financial Sense(R) Newshour
Market Update with Craig Johnson: Sell Signals Flash, Energy Heats Up, Yields Loom

Financial Sense(R) Newshour

Play Episode Listen Later Sep 18, 2026 17:16


Sep 18, 2026 – "Bullseye" Craig Johnson of Piper Sandler discusses recent market turmoil following Fed rate hikes, highlighting weak market breadth and the likelihood of deeper consolidation or correction ahead. He warns of risks tied to rising debt...

Financial Sense(R) Newshour
This Week's Market Wrap: Fed Hike, AI Safety, and Weakening Market Breadth

Financial Sense(R) Newshour

Play Episode Listen Later Sep 18, 2026 17:57


Sep 18, 2026 – The Fed raised rates as expected, but Chair Warsh's comments signaled a focus on trends, not single data points. Oil above $100, 10-year yields near 5%, and growing AI and crypto policy debates add risk, while market breadth is weakening...

Financial Sense(R) Newshour
Robert Rapier: Why Diesel Crisis Is Worse Than Gas Pump Shock

Financial Sense(R) Newshour

Play Episode Listen Later Sep 18, 2026 24:07


Sep 18, 2026 – Energy expert Robert Rapier joins Jim Puplava to unpack a tightening global energy crisis, as the effective closure of the Strait of Hormuz sends diesel prices soaring and crack spreads to record highs. Rapier explains why depleted...

Financial Sense(R) Newshour
Dr. Alan D. Thompson on GPT-6, 'Proto-ASI', and Recursive Self-Improvement (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 18, 2026 1:21


Sep 17, 2026 – Are we crossing the threshold from artificial intelligence to superintelligence? Dr. Alan D. Thompson joins Cris Sheridan to explain how frontier AI models have outgrown human-designed tests—and why physical embodiment...

Financial Sense(R) Newshour
Martin Armstrong on WWIII Risks, 2030 Debt Crisis, and Soaring Commodities (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 17, 2026 4:08


Sept 17, 2026 – Escalating wars and supply disruptions are fueling a major commodity boom that could last into the 2030s, says well-known global forecaster Martin Armstrong in today's exclusive interview with FS Insider. Martin provides his big picture...

Kings Weekly Podcast
The Best Power Forwards in Sacramento Kings Franchise History

Kings Weekly Podcast

Play Episode Listen Later Sep 17, 2026 33:41


Nick and Ray discuss the greatest power forwards in the history of the Sacramento Kings franchise. After a brief discussion of the recent Elfrid Payton signing to open the show, they give out their three “All Kings” nods to the three best PFs in the history of the franchise, as well as highlighting some of the other great power forwards who have worn a uniform for the franchise. They start off with their first major disagreement in the series about how to rank the two greatest power forwards in the history of the franchise: Chris Webber and Jerry Lucas. Then, they cover the Third Team All-Franchise power forward and one of the greatest what-ifs in NBA history: Maurice Stokes. Then, they move on to some of the other great power forwards in franchise history: Johnny Green, Wayman Tisdale, and Bob Boozer. Finally, they wrap up with a brief discussion of the all-time leader in games played for the Sacramento Kings, Jason Thompson. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Financial Sense(R) Newshour
Satyajit Das: The Financial Engineering Behind the AI Boom (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 16, 2026 1:46


Sep 15, 2026 – Financial author and derivatives expert Satyajit Das joins FS Insider's Cris Sheridan to examine the risks he sees building beneath the AI boom, as higher borrowing costs and mounting global debt put pressure on the financial system...

Patient from Hell
What Patient-Centered Research Looks Like, From a Nurse Who Became the Patient | Janice Cowden

Patient from Hell

Play Episode Listen Later Sep 16, 2026 30:24


This episode is sponsored by Gilead Sciences. Gilead had no involvement or input in the podcast content. Gilead is working to transform how cancer is treated. We are innovating with next-generation therapies, combinations, and technologies to deliver improved outcomes for people with cancer. From antibody drug conjugates and small molecules to cell therapy-based approaches, our portfolio and pipeline assets are creating new possibilities for people with cancer.Recorded on location at the San Antonio Breast Cancer Symposium, December 2025.Metastatic triple-negative breast cancer remains the breast cancer subtype with the fewest targetable biomarkers and the shortest treatment algorithm. When a trial reports a double-digit progression-free survival in the first-line setting, it is worth understanding what that actually changes and how the trial was designed with patient outcomes at the center.This episode was recorded in December 2025, before regulatory action. On June 24, 2026, the FDA approved sacituzumab govitecan-hziy for two first-line indications in triple-negative breast cancer: as a single agent for adults with unresectable locally advanced or metastatic TNBC who are not candidates for PD-1 or PD-L1 inhibitor-based therapy supported by ASCENT-0, and in combination with pembrolizumab for adults whose tumors express PD-L1 with a CPS of 10 or greater supported by ASCENT-04. Janice's speculation in this episode about how PD-L1 status might factor into the guidelines has since been answered by the label.ASCENT-04/KEYNOTE-D19 NCT05382286 was a phase 3, open-label, randomized trial of 443 patients with previously untreated locally advanced unresectable or metastatic TNBC whose tumors expressed PD-L1 at a CPS of 10 or greater by the 22C3 assay. Participants were randomized 1:1 to sacituzumab govitecan plus pembrolizumab or to physician's choice of chemotherapy plus pembrolizumab. Patients in the control arm with centrally confirmed progression were offered crossover to sacituzumab govitecan.0:00 Live from the San Antonio Breast Cancer Symposium0:30 The METAvivor ribbon and what the pink ribbon leaves out1:35 Diagnosed in 2016 with a median overall survival of 9 to 15 months2:26 Nine years later3:20 From pediatric nursing to research advocacy4:30 What has changed since 2017, and what has not5:26 2011: when chemotherapy was the only option5:55 On not knowing a relevant clinical trial existed6:47 Why metastatic TNBC still has no maintenance therapy7:25 What first-line treatment looks like today8:25 Inside ASCENT-049:09 Progression-free survival, defined9:59 Why a double-digit PFS is notable in this subtype11:20 Why each subsequent line of treatment works for less time11:52 How many patients never reach second line12:50 The case for a stronger first-line option13:21 Crossover design, and why it matters to patients14:33 What crossover means in a randomized trial15:56 Patient advocates in clinical trial design18:59 Quality of life versus quantity of life21:48 Rapid fire: metastatic breast cancer and metastatic TNBC23:06 Rapid fire: first line, second line, progression-free survival24:00 Rapid fire: immunotherapy and antibody-drug conjugates24:59 Advice for the newly diagnosed26:04 What she wants next: a biomarker26:52 On ADCs, tolerability, and the need for novel targetsJanice Cowden, RN is a research patient advocate living with metastatic triple-negative breast cancer. She practiced as a registered nurse for approximately 22 years, primarily in pediatrics, and later worked as a pharmaceutical sales representative. She was diagnosed with stage I triple-negative breast cancer in 2011 and with metastatic disease in 2016, and completed the Living Beyond Breast Cancer advocacy training program in 2017.This podcast is intended for educational and informational purposes only and should not be considered medical advice.

Financial Sense(R) Newshour
AI vs. Advisors: When AI Research Meets Human Judgment

Financial Sense(R) Newshour

Play Episode Listen Later Sep 14, 2026 18:51


Sep 14, 2026 – Is AI helping you invest smarter or steering you toward the same crowded trades? In this Lifetime Planning episode, Nick Kile and Brendan McMurtrie explore the opportunities and pitfalls of AI-driven investing, from hidden portfolio concentration...

Financial Sense(R) Newshour
Chris Puplava: Markets Can't Ignore This Energy Shock

Financial Sense(R) Newshour

Play Episode Listen Later Sep 12, 2026 20:32


Sep 11, 2026 – Stocks are flashing warning signs beneath the surface. Financial Sense CIO Chris Puplava examines how narrowing market leadership, rising energy costs and renewed rate-hike expectations are testing the rally. With consumer stocks...

Financial Sense(R) Newshour
Jim Welsh: Why I'm Raising Cash

Financial Sense(R) Newshour

Play Episode Listen Later Sep 12, 2026 23:21


Sep 11, 2026 – Can stocks keep defying rising rates and soaring energy costs? Macro Tides' Jim Welsh explains why he expects a Fed hike—and why it may not launch a prolonged tightening cycle. He flags weakening market breadth, crowded AI...

Financial Sense(R) Newshour
Jordan Roy-Byrne: Gold Miners Just Flashed a Signal Not Seen in 20 Years

Financial Sense(R) Newshour

Play Episode Listen Later Sep 11, 2026 30:09


Sep 11, 2026 – Jordan Roy-Byrne explains why he believes gold and silver's sharp correction has ended—and why the next advance could be powerful. Highlighting gold miners' leadership, improving profitability, and potential capital flows out of stocks...

Financial Sense(R) Newshour
This Week's Market Wrap: $100 Oil, 5% Yields, and Increasing Odds for Fed Hike

Financial Sense(R) Newshour

Play Episode Listen Later Sep 11, 2026 19:54


Sep 11, 2026 – Oil above $100, Treasury yields near 5%, and rising Fed hike odds tighten financial conditions. AI spending buoys market leaders, but weakening breadth and Iran tensions raise risks, making the Fed outlook and capital protection...

Financial Sense(R) Newshour
Adriano Bosoni: Risks of Widening Ukraine War, False Flag Attacks (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 11, 2026 1:37


Sep 11, 2026 – The front lines may be frozen, but the economic fallout is widening. Adriano Bosoni, RANE's director of geopolitical analysis, examines how deep strikes, strained air defenses and Black Sea shipping disruptions are reshaping...

Financial Sense(R) Newshour
David Woo on $100 Oil and Major Cyberattacks (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 10, 2026 3:11


Sep 10, 2026 – Markets may be underpricing two interconnected threats: an oil shock and a reversal in the AI boom. In this interview with Cris Sheridan, macro strategist David Woo explains why he sees a path to $150 crude if Gulf negotiations unravel...

Financial Sense(R) Newshour
Ed Yardeni: Roaring 2020s Driven by $90T G-Shaped Economy (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 7, 2026 1:11


Sep 7, 2026 – Ed Yardeni discusses his bullish outlook for the S&P 500, raising his year-end target to 8,400 and projecting 10,000 by decade's end. He highlights the “Roaring 2020s,” G-shaped vs. K-shaped economy, strong earnings and productivity...

Financial Sense(R) Newshour
Why Everything You Know About Cancer Might Be Wrong: A Conversation with Dr. Thomas Seyfried (Replay)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 7, 2026 40:11


Sep 7, 2026 – Boston College's Dr. Thomas Seyfried tells Financial Sense Newshour's Jim Puplava why he believes cancer is a mitochondrial metabolic disease—not primarily a genetic one. He explains why conventional treatments may miss the real driver...

Kinsella On Liberty
KOL497 | Debate: “Should Free Cities Protect Intellectual Property?” Free Cities Foundation Annual Conference — Próspera, Honduras 2026

Kinsella On Liberty

Play Episode Listen Later Sep 7, 2026


Kinsella on Liberty Podcast: Episode 497. Yesterday (Sep. 5, 2026) I participated in the debate: “Should Free Cities Protect Intellectual Property?” with IP attorney Brian O'Beirne, moderated by Tipolis CFO Alex VossTopic, held at the Free Cities Foundation annual Conference, Próspera, Honduras, Sept. 4–7 (Sat. Sept. 5, 2026) (SK profile; O'Beirne profile) (see Free Cities Foundation Annual Conference — Próspera 2026). https://youtu.be/4GWPdxnpCOI I spoke for 4 minutes, then Brian, and then we had an exchange and audience questions for the remaining time. It was very civil unlike some other debates I've participated in. (( KOL038 | Debate with Robert Wenzel on Intellectual Property; KOL123 | Debate with Jan Helfeld on Anarchy vs. Limited Government. )) One thing I liked is that Brian started off admitting, first, that he has some sympathy for my anti-IP position, and, second, that he acknowledged that opposition to IP is the libertarian position--unlike other libertarian IP proponents who claim that IP rights are compatible with libertarianism, if not the "heart and core" (Ayn Rand) or property rights or  . (( Objectivists: “All Property is Intellectual Property” A Recurring Fallacy: “IP is a Purer Form of Property than Material Resources” The “Ontology” Mistake of Libertarian Creationists. )) "primary property" (Galambos). (( Galambos and Other Nuts; Rothbard and Galambosians; The Galambosians strike back; “Around this time I met the Galambosian.”; Libertarian Sci-Fi Authors and Copyright versus Libertarian IP Abolitionists; Was Galambos an IP Thief?; Galambos the Crank; Shades of Galambos: Man tries to copyright his name. )) Transcript and shownotes below. This was also so purely a perfect 4 minutes I couldn't believe it — Alex (@AlexDVoss) September 16, 2026 Note: I misspoke a couple times in my 4-minute hurried initial presentation: I said "court" a few times when I meant the crown (king; government; state), granting patents in favor of "court" cronies; and the crown and/or church (Attila and the Witchdoctor) (( See Ayn Rand, “For the New Intellectual,” in For the New Intellectual: The Philosophy of Ayn Rand (New York: Signet/New American Library, reprint of Random House, 1961; first Signet printing December 1963), pp. 7–48; Now Online: 'Faith and Force: Destroyers of the Modern World'; "Faith" entry in Ayn Rand Lexicon; Bruce Goldberg, “Ayn Rand's ‘For the New Intellectual'” (1961), n.14. )) controlling what books could be printed via control of the scribes, pre-printing press, and of the publishing houses thereafter via the Stationer's Company. Forgive me, forgive me. Re other IP debates: In his defense, as far as I know my opponent does not purport to have a coherent theory of property or IP or libertarianism. Go here https://t.co/rRs61a68M6 and search for the word "debate" for several others -- Richard Epstein was more coherent, but totally utilitarian; he… — Stephan Kinsella (@NSKinsella) September 8, 2026 Related/mentioned “Conversation with an author about copyright and publishing in a free society” (Jan. 23, 2012) Copywrong: copyright as censorship KOL346 | Copyright and Satoshi's Legacy: The Tatiana Show, with Tatiana Moroz How to Improve Patent, Copyright, and Trademark Law FDA and Patent Reform: A Modest Proposal “Are Patents Needed to Make Up for FDA Kneecapping?” (July 2, 2011) KOL190 | On Life without Patents and Copyright: Or, But Who Would Pick the Cotton? (PFS 2015) Mark Lemley: The Very Basis Of Our Patent System… Is A Myth (July 29, 2011) Frank H. Easterbrook, “Intellectual Property Is Still Property,” Harv. J.L. & Pub. Pol'y 13, no. 1 (Winter 1990): 108–118, pp. 109–110 (on inevitable disclosure) Intellectual Property's Great Fallacy KOL190-2 | Part 2: On Life without Patents and Copyright: Or, But Who Would Pick the Cotton? — Panel Discussion, Hoppe, Dürr, Kinsella, van Dun, Daniels (PFS 2015) The Overwhelming Empirical Case Against Patent and Copyright “The Problem with Intellectual Property,” in Handbook of the Philosophical Foundations of Business Ethics Do Business Without Intellectual Property (Liberty.me, 2014) The Universal Principles of Liberty Shownotes and Summary Overall Summary of Debate At the Free Cities Conference in Próspera, Alex Voss moderated Stephan Kinsella against Brian O'Beirne on whether intellectual property is legitimate and what a free city should do about it. Kinsella argued that property exists only to allocate scarce, rivalrous means (self-ownership, first use, contract, restitution); ideas are guides to action, not ownable things. Patent and copyright are statutory privileges—historically Crown monopolies and press control—that impose unconsented negative servitudes on other people's property, block independent inventors, enrich large firms, and should be abolished. O'Beirne treated IP as a right in human ingenuity and a last individual defense against corporate oligopoly and central banking. He granted that the present code is broken (thickets, trolls, life-plus-70) but said abolition would hand creators' work to those same firms; the answer is reform, sector-scaled terms, and symmetry of rights, not erasure. On practice they were closer. Both said Próspera should not pick a treaty fight that threatens the zone. O'Beirne wanted opportunistic protection to attract builders (CAFTA-DR/TRIPS, Infinita). Kinsella wanted the lightest lawful touch—no treble damages, no criminal copyright, shorter terms, Founders' copyright, no software copyright—and stressed that patents are territorial, so skipping a local patent office does not stop U.S. or European filings and is largely irrelevant for exporters. Audience questions (expiry of “property,” fire and the wheel, trademarks, pharma/FDA) replayed the same split: O'Beirne qualified rights by the common good and novelty; Kinsella called consistent IP perpetual, the patent-bargain a myth, and patents a patch on the FDA. Summary of Kinsella's position (from Grok, based on the transcript and his pre-debate email exchange with O'Beirne and Voss) Stephan Kinsella's case against intellectual property, as he put it to Alex Voss before the session and then on stage, has two layers that he keeps joined: a rights argument about what property is, and a practical argument about what a free city should do when it cannot get the ideal. Voss had already framed the dispute narrowly: patents and copyrights—exclusive rights in inventions and works that bind strangers without a contract. Contracts, NDAs, employment terms, and trade secrets were set aside as different questions. Voss's sketch of Kinsella's theory (conflict over scarce means; title by appropriation or transfer; creation not an independent source of title; information as patterning of an already-owned substrate; IP as a veto over others' things) Kinsella accepted, then added history, scale of harm, and institutional design. 1. What property is for The four-minute opening is the core. We do not live in the Garden of Eden. Action uses two things: scarce means that can cause results, and knowledge that tells us how to use them. Knowledge can be copied; a hammer or a factory cannot be used two incompatible ways at once. Because people have free will, conflict over those scarce means is always possible. Property rights are the norms that let people possess and use those means peacefully—self-ownership of the body; original appropriation of unowned external resources; contract; restitution for wrongs. That, he says, is the spine of Roman law, common law, and a consistent libertarianism. Ideas do not fit. They are not “conflictable.” They exist only as the patterning of some already-owned substrate (paper, a chip, a machine). You own what you make because you already owned the inputs, not because “creation” mints a new title. Patent and copyright therefore do not add a new kind of property. They give A a legally enforceable veto over how B uses B's own press, factory, or chemicals. In the debate he calls that a nonconsensual negative easement or servitude—the same structure as a restrictive covenant, minus the neighbors' consent. Consent is the whole difference. He is explicit that he does not care about “symmetry.” A rule that everyone may sue everyone for defamation, or for welfare, would be symmetric and still unjust. First-to-the-patent-office does not even guarantee uniqueness: independent inventors are blocked. That is enough, for him, to reject the system as a matter of justice, before any spreadsheet about incentives. 2. History, legislation, and the dishonest name He adds what Voss's paragraph left out. Patent began as Crown privileges to shield favorites from competition (Statute of Monopolies, 1623). Copyright began as control of the press and unapproved speech (Statute of Anne, 1710). They did not grow out of common-law title; they were statutes. In the email he presses a further institutional point: patent and copyright cannot exist without a legislature empowered to make law. Organic court-made law—Roman law, common law, Restatements, even a scholarly compilation adopted as a code—resolves disputes over scarce things. It does not invent a 17-year monopoly in a pattern. A free city that takes common-law or Restatement principles as its base, and treats legislation as rare and suspect, has a structural reason not to enact IP at all. His Universal Principles of Liberty are meant that way: not as a statute. He tells Brian that origin is not his only argument (so the “genetic fallacy” charge misses). He also opposes trademark, defamation, and trade secret, some of which did come through common law. “Sometimes the common law gets it wrong.” The name “intellectual property” is the propaganda move: a state privilege flying the flag of property and capitalism. That is why he calls it intellectual privilege and why, in the email,...

Financial Sense(R) Newshour
This Week's Market Wrap: Selectivity Rises Amid Oil Gains and Shifting Leadership

Financial Sense(R) Newshour

Play Episode Listen Later Sep 5, 2026 16:55


Sep 4, 2026 – Oil is back above $90, the August jobs report has kept a Fed rate hike in play, and market breadth has weakened even as the S&P 500 remains near its highs. At the same time, AI spending continues to look exceptionally strong, and several areas...

Financial Sense(R) Newshour
Big Picture Macro Investing: Oil, Inflation, and Hard Assets

Financial Sense(R) Newshour

Play Episode Listen Later Sep 4, 2026 37:50


Sep 4, 2026 – We are witnessing one of the most significant macroeconomic shifts in over half a century. US energy reserves are approaching operational limits as they are drawn down to buffer disruptions from the Iran conflict, while the energy sector faces a multi-trillion...

Financial Sense(R) Newshour
Jeff Christian: Gold Heading to $5,000 as Bull Market Resumes (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 4, 2026 3:53


Sep 3, 2026 – Gold just ripped more than $700 higher in a single month—and according to one of the most accurate commodity forecasters we speak with, this is only the beginning. In today's FS Insider interview, Jeff Christian explains why the recent rate-driven...

Financial Sense(R) Newshour
Kurt Kallaus: America's Oil Reserves Are Running Low—Hard Decisions Ahead (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 3, 2026 2:00


Sep 2, 2026 – The bond vigilantes are back—and oil is fueling the fire. Kurt Kallaus reveals why we're "living on borrowed barrels," how draining reserves could jolt markets by October, and the surprising sectors he's buying while....

Blood Cancer Talks
Episode 74. Myeloma Updates from ASCO/EHA 2026 with Dr. Prashant Kapoor

Blood Cancer Talks

Play Episode Listen Later Sep 3, 2026 57:43


Blood Cancer Talks — Show NotesEpisode: Best of ASCO/EHA 2026 — Multiple Myeloma & AL AmyloidosisGuest: Dr. Prashant Kapoor, MD Professor of Medicine, Mayo Clinic, Rochester, MN Chair, Myeloma, Amyloidosis and Dysproteinemia Group, Mayo ClinicEpisode OverviewIn this episode, the hosts sit down with Dr. Prashant Kapoor to review the highest-impact multiple myeloma and AL amyloidosis data from the 2026 ASCO and EHA annual meetings. The discussion centers on the rapidly shifting relapsed/refractory myeloma landscape, where a wave of phase 3 trials of T-cell engaging immunotherapies (bispecific antibodies and CAR T) have now each demonstrated superiority over traditional triplet regimens. Topics Covered1. MajesTEC-3Phase 3, open-label trial of teclistamab + daratumumab SC (n=291) vs. investigator's choice of DPd or DVd (n=296) in 587 patients with relapsed/refractory myeloma and 1–3 prior lines; prior BCMA-directed therapy and anti-CD38-refractory disease were exclusions (only 5% CD38-exposed, none were refractory). Initially presented at ASH 2025, with cytogenetic subgroup data updated at EHA 2026.Key results (34.5-month median follow-up):Median PFS not reached with Tec-Dara vs. 18.1 months with DPd/DVd; 36-month PFS 83.4% vs. 29.7% (HR 0.17)36-month OS 83.3% vs. 65.0% (HR 0.46)Severe infection rate front-loaded: ~35% → ~17% between the first and second 6-month windows, plateauing at ~10–11%/window beyond 12 months; overall grade 3–4 infection 54%, 4.6% fatal infections (mostly without IVIG prophylaxis)EHA 2026 cytogenetic subgroup: 2-year PFS 90% (0 HRCA), 82% (1 HRCA), 76% (≥2 HRCA) — vs. only 14% with DPd/DVd in patients with ≥2 HRCADiscussion points: Applicability to patients at 1st/2nd relapse seen in clinic today; whether infection risk limits use of Tec-Dara at first relapse; implications of the high-risk cytogenetic subgroup data.2. MajesTEC-9Phase 3 trial of teclistamab monotherapy vs. investigator's choice of PVd or Kd in relapsed/refractory myeloma enrolling a heavily anti-CD38-refractory population (100% CD38-exposed, 85% refractory) — the population MajesTEC-3 excluded. Natural comparator: CARTITUDE-4 (phase 3, cilta-cel vs. DPd/PVd in Len-refractory myeloma, 1–3 prior lines, ~25% CD38-refractory/exposed).Key results (~18-month median follow-up):18-month PFS 70% vs. 27% (HR 0.29); 18-month OS 79% vs. 69% (HR 0.6), despite ~2/3 of control-arm patients receiving BsAb/CAR T as subsequent therapyDiscussion points: Cross-trial comparison with CARTITUDE-4 — comparable 18-month PFS on cross-trial comparison, but differing populations (CARTITUDE-4 required Len-refractory disease; MajesTEC-9 enrolled a more CD38-refractory population) and differing maturity (~3-year vs. ~1.5-year follow-up); how Dr. Kapoor chooses between teclistamab and cilta-cel at earlier-line relapse in Len- and CD38-refractory patients, given the divergent toxicity profiles — ongoing infection risk with continuous BsAb dosing vs. the one-time cilta-cel infusion with its rare but potentially irreversible delayed neurotoxicity, IEC-enterocolitis, and CTTLN risk.3. MonumenTAL-3Phase 3 trial — the first phase 3 study of a GPRC5D-targeted bispecific — randomizing 864 patients with relapsed/refractory myeloma (mostly Len-refractory, ~10% CD38-exposed but none refractory) 1:1:1 to Tal-Dara-Pom (n=287), Tal-Dara (n=287), or DPd (n=290), each Talq arm compared against the common DPd control. Presented by Peter Voorhees at EHA 2026 and simultaneously published in NEJM.Key results (24.6-month median follow-up):Both Talq arms significantly improved PFS over DPd: Tal-DP HR 0.28, Tal-D HR 0.33 (both P

Financial Sense(R) Newshour
The Death of a Decision Maker: You Built the Plan—But Can Anyone Else Run It?

Financial Sense(R) Newshour

Play Episode Listen Later Sep 1, 2026 39:33


Aug 31, 2026 – When one spouse manages all the finances, passwords, and key relationships, their sudden death can trigger legal, financial, and operational chaos. Today, we explore the risk posed by the "death of a decision maker" and three...

Financial Sense(R) Newshour
Rick Rule's Commodity Picks: "You Ain't Seen Nothing Yet" (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Sep 1, 2026 3:04


Sep 1, 2026 – On the very week the CRB Commodity Index breaks out to a fresh 16-year high, legendary resource investor Rick Rule sits down with FS Insider's Cris Sheridan to deliver a masterclass on where we are in the commodity bull market...

Financial Sense(R) Newshour
Data Shows AI Race About to Hit Utility Wall, Says Coeus Institute's Michai Morin (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Aug 28, 2026 4:34


Aug 27, 2026 – As frontier AI models converge on near-identical performance, Coeus Institute's Michai Morin argues the industry's defining battle is shifting from intelligence to economics—and the West may be losing. In a wide-ranging interview...

Financial Sense(R) Newshour
This Week's Market Wrap: AI's Falling Costs, Software's Comeback, and a Hawkish Warsh

Financial Sense(R) Newshour

Play Episode Listen Later Aug 28, 2026 16:11


Aug 28, 2026 – Nvidia and Marvell reveal AI's next phase, software stages a comeback after the "SaaS apocalypse," and a hawkish Warsh puts a Fed hike back on the table. Ryan Puplava breaks down where growth, value, and rate risk collide for investors...

Financial Sense(R) Newshour
Garry Golden: AI Backlash, Robot Economy, and Race to AGI (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Aug 27, 2026 1:04


Aug 26, 2026 – Futurist Garry Golden returns to discuss why the backlash against AI data centers has gone bipartisan—from blue states to Texas's new moratorium. He explains why slowing AI is unlikely, how humanoid robotics could reshape the global economy

CruxCasts
Bravo Mining (TSXV:BRVO) - Luanga Advances Toward PFS With Multiple Funding Options

CruxCasts

Play Episode Listen Later Aug 27, 2026 29:41


Interview with Luis Azevedo, Chairman and CEO, Bravo MiningOur previous interview: https://www.cruxinvestor.com/posts/bravo-mining-tsxvbrvo-double-grades-and-resource-up-to-236-million-tons-in-tier-one-pgm-deposit-7934Recording date: 25th August 2026Bravo Mining (TSXV:BRVO, OTCQX:BRVMF) is advancing its 100%-owned Luanga PGM+Au+Ni deposit in Brazil's Carajás Mineral Province through a Pre-Feasibility Study guided for Q3 2026, while simultaneously extending two secondary discoveries — a nickel-copper sulphide system at the Babylon target and an early-stage copper-gold exploration programme — that management believes could add materially to the project's long-term optionality.The immediate news is a set of assay results from drill hole DDH26LU347 at Babylon, adjacent to Luanga's North Sector. The hole intercepted 13.4 metres at 1.55% nickel, 0.33% copper and 2.02 g/t PGM+Au (including a higher-grade 6.7-metre interval at 2.25% nickel and 3.14 g/t PGM+Au), plus a separate 6.0-metre interval grading 6.81 g/t PGM+Au. CEO Luis Azevedo characterises the nickel-copper result as evidence the deposit could ultimately support underground mining grades in addition to its established open-pit resource, with a large Induced Polarisation anomaly at roughly 700 metres depth now queued for follow-up drilling.On the core PGM story, the PFS — pushed one quarter from Q2 to Q3 2026 — is being built around metallurgical testwork showing Jameson Cell flotation technology can lift platinum, palladium and gold recoveries by 5-10% and nickel recoveries by 5-30% against conventional Denver cells, while cutting mass pull by up to 50%. Glencore Technology has independently reviewed the metallurgical database and indicated it is prepared to issue performance guarantees on the assumptions. Azevedo argues the practical effect is a larger, more profitable pit rather than a simple recovery uplift, which is the stated reason the study needed the extra quarter.Bravo held approximately $94 million in cash at the time of interview, which management says funds the PFS, permitting and 2026 drilling without near-term dilution. Beyond the treasury, the company has structured but not yet drawn on two further levers: an indicative $280 million offer for a portion of its gold credit, and an existing $300 million credit line from Orion. A PGM offtake has drawn interest from multiple parties but remains unpriced pending bankable feasibility numbers.On permitting, Bravo already holds its preliminary licence and plans to submit for the Installation Licence within one to two weeks of the PFS release, targeting approval within six months to a year based on the company's track record with Brazilian regulators. A construction decision is targeted roughly six months after the PFS, with construction possible from mid-2028, pending a Q1 2027 resource update and a Q3 2027 Definitive Feasibility Study.The 2025 PEA's vertically-integrated smelter scenario has also become more attractive: rising sulphuric acid byproduct pricing lifts that case's NPV from approximately $1.2 billion to $1.68 billion versus the base concentrate-sale case, though management has not yet decided on timing.Separately, a copper-gold division led by 31-year Vale veteran Fabio Masotti is running IP surveying ahead of an 8,000-metre H2 2026 drill programme — a third, still unpriced source of optionality that management says could eventually support a standalone corporate structure if results warrant it.Learn more: https://cruxinvestor.com/companies/bravo-miningSign up for Crux Investor: https://cruxinvestor.com/subscribe

Stocks To Watch
Episode 866: Rua Gold ($RUA | $NZAUF): Gearing Up for the Next Stage of Growth at Reefton & Glamorgan

Stocks To Watch

Play Episode Listen Later Aug 26, 2026 16:59


This interview is disseminated on behalf of Rua Gold Inc.From securing regulatory approval to drill at the Glamorgan Project to advancing a pre-feasibility study (PFS) and permitting at Reefton, Rua Gold (TSX: RUA | NZX: RGI | OTC: NZAUF | FSE: X9R) is progressing key milestones across its New Zealand portfolio. CEO and Director Robert Eckford highlights the fully funded 9,000-metre Glamorgan drill program, Reefton's PFS and fast-track permitting process, and the key catalysts ahead as the company works toward transitioning from explorer to producer.Learn more: https://ruagold.com/Watch the full YouTube interview here: https://youtu.be/z37qMywBmE0And follow us to stay updated: https://www.youtube.com/@stockstowatchofficial 

Financial Sense(R) Newshour
The New Rules of Saving for Your Kids: Tax-Free Growth, FAFSA Hacks and the $1,000 Government Seed

Financial Sense(R) Newshour

Play Episode Listen Later Aug 25, 2026 27:34


Aug 24, 2026 – Wealth advisors Crystal Colbert and Nick Kile break down the four best ways to build long-term wealth for your children in 2026—including 529 plans, UTMAs, custodial Roth IRAs, and the brand-new Trump Account. Discover expanded K-12...

Financial Sense(R) Newshour
$17,000 Gold? Pierre Lassonde on the 'Anti-Dollar' Bull Market Amid $40 Trillion Debt

Financial Sense(R) Newshour

Play Episode Listen Later Aug 25, 2026 43:40


Aug 25, 2026 – Legendary gold investor Pierre Lassonde joins Jim Puplava to reveal why gold's current bull market may only be the beginning of a much larger advance throughout the remainder of this decade. Lassonde exposes striking historical...

Financial Sense(R) Newshour
The $4 Billion Signal That Sent Gold Soaring

Financial Sense(R) Newshour

Play Episode Listen Later Aug 22, 2026 16:38


Aug 21, 2026 – Chris Puplava explains why Treasury Secretary Bessent's buyback announcement was a pivotal "whatever it takes" moment—and what it could mean for your portfolio. He reveals how the US may now be sacrificing the dollar to cap...

Financial Sense(R) Newshour
John Williams: Real Inflation Rate Closer to 11%

Financial Sense(R) Newshour

Play Episode Listen Later Aug 21, 2026 20:57


Aug 20, 2026 – Is official inflation telling the full story? Economist John Williams of ShadowStats joins Jim Puplava to examine how methodological changes to the CPI since 1980 have reshaped reported inflation, and what his alternate measure...

Financial Sense(R) Newshour
Vincent Randazzo: Materials on the Verge of Major Breakout

Financial Sense(R) Newshour

Play Episode Listen Later Aug 21, 2026 20:08


Aug 21, 2026 – How strong is the current bull market and which sectors are outperforming? Vincent Randazzo of ViewRight Advisors joins Jim Puplava to reveal why strong market breadth is leading the S&P 500 higher despite rising rates, oil, and...

Financial Sense(R) Newshour
This Week's Market Wrap: Bond Yields Hit Multi-Decade Highs

Financial Sense(R) Newshour

Play Episode Listen Later Aug 21, 2026 23:52


Aug 21, 2026 – The biggest move this week wasn't semis or Iran—it was bonds. 30-year Treasury yields hit 5.3%, a two-decade high. Investors are demanding more compensation for duration amid $40T debt, AI financing needs, and rising oil...

Financial Sense(R) Newshour
Jim Roemer: How a Super El Niño Could Reshape Food Prices and Commodity Markets (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Aug 19, 2026 1:22


Aug 19, 2026 – Meteorologist and commodity trading advisor Jim Roemer explains the factors increasing the odds of a Super El Niño, threatening to drive soft commodity prices higher and also bring disruptive weather patterns globally...

Financial Sense(R) Newshour
From Nursery to Nest Egg: Financial Planning for New and Expecting Parents

Financial Sense(R) Newshour

Play Episode Listen Later Aug 18, 2026 34:09


Aug 17, 2026 – Brendan McMurtrie and Crystal Colbert of Financial Sense Wealth Management discuss essential financial planning steps for new and expecting parents. Topics include budgeting for baby expenses, optimizing health insurance...

CruxCasts
Namibia Critical Metals (TSXV:NMI) - Partnership and $23M Earn-In Secured for Lofdal HREE Project

CruxCasts

Play Episode Listen Later Aug 17, 2026 22:21


Interview with Darrin Campbell, President & CEO of Namibia Critical Metals Inc.Our previous interview: https://www.cruxinvestor.com/posts/namibia-critical-metals-tsxvnmi-japan-backed-path-to-dfs-in-q2-2027-9891Recording date: 13th August 2026Namibia Critical Metals (TSXV:NMI) has reached a pivotal moment in the development of its Lofdal Heavy Rare Earth Project in Namibia. In July 2026, the Japan Organization for Metals and Energy Security (JOGMEC) and Toyota Tsusho Corporation completed a C$23 million earn-in commitment, roughly 18 months ahead of the original March 2028 schedule, securing a combined 50% participating interest in the project. The two partners formed TJ Namibia Rare Earths Corporation (TJNREC) to hold that interest, and JOGMEC has separately committed up to C$47.668 million (approximately ¥5.5 billion) to capitalise the new entity, funding Lofdal through Definitive Feasibility Study completion and toward a Final Investment Decision.Critically, all project funding from this point forward is structured as non-interest-bearing, non-dilutive Pre-FID Capital Funding - a mechanism CEO Darrin Campbell described as a temporary free carry that removes near-term financing risk without forcing Namibia Critical Metals to make a dilution decision until FID itself. The company retains the option to participate at up to 45% ownership or dilute to a carried floor of 21%, with management signalling a preference to retain maximum exposure given the project's economics.The economics, laid out in a December 2025 PFS, show a 13-year mine life producing 2,000 tonnes of total rare earth oxide annually, including significant dysprosium, terbium and yttrium output. A base case using moderate pricing generates a $275 million after-tax NPV and 19% IRR on $348 million of capex; a divergent case reflecting the elevated non-Chinese pricing seen over the past 18 months delivers a $748 million after-tax NPV and 35% IRR. Campbell noted current market conditions increasingly resemble the divergent scenario.Technical work continues in parallel. A 13,000-metre, 83-hole drill programme launched in June 2026 is targeting a maiden resource at the Area 5 xenotime system, the project's first deep test hole at Area 4 to approximately 800 metres for underground mining studies, and infill drilling at Area 2B. SGS has been awarded pilot-scale flotation and hydrometallurgical testwork contracts aimed at producing separated - rather than mixed - light and heavy rare earth products, which Campbell said better matches offtaker demand. A DFS completion target of Q3 2027 is intended to lead into an FID shortly after.Despite this de-risking and the depth of sovereign-industrial backing, Campbell argues the market continues to price Lofdal as an early-stage exploration story, at roughly 0.15-0.2x price-to-NAV versus 0.4-0.8x for comparable PFS/DFS-stage peers. He attributes the gap to thin liquidity, minimal institutional coverage as the company has not needed to raise meaningful capital in six years due to JOGMEC funding, and market confusion over the earn-in's dilution mechanics. Final offtake pricing terms with the Japanese consortium remain under negotiation, representing a further catalyst to watch as the project approaches FID.View Namibia Critical Metals' company profile: https://www.cruxinvestor.com/companies/namibia-critical-metals-incSign up for Crux Investor: https://cruxinvestor.com

Financial Sense(R) Newshour
This Week's Market Wrap: Wall Street Shrugs Off a Weakening Consumer to Hit New Highs

Financial Sense(R) Newshour

Play Episode Listen Later Aug 15, 2026 18:35


Aug 14, 2026 – Inflation data cooled enough to ease rate-hike fears. The consumer is showing real cracks in retail sales and sentiment. AI infrastructure spending keeps accelerating, led by Nvidia's $500 billion financing push. Market breadth is broadening beyond mega-cap tech...

Financial Sense(R) Newshour
Mark Mills: AI's Energy Boom Is 10x Bigger Than Data Centers

Financial Sense(R) Newshour

Play Episode Listen Later Aug 13, 2026 50:57


Aug 12, 2026 – Energy expert Mark Mills at the National Center for Energy Analytics upends conventional wisdom in this must-hear Financial Sense Newshour conversation with Jim Puplava—one that could reshape how you think about...

Financial Sense(R) Newshour
Oil Super Spike Warning: Ron William on the 1970s Parallel Nobody's Pricing In

Financial Sense(R) Newshour

Play Episode Listen Later Aug 13, 2026 27:28


Aug 13, 2026 – A shock to the oil market may be just getting started. In this Financial Sense interview, Jim Puplava sits down with Ron William of RW Advisory to break down why the Strait of Hormuz, record-low strategic reserves, and a fragile geopolitical standoff between the US and Iran could trigger a repeat of a 1970s-style oil super spike...

Financial Sense(R) Newshour
Dr. Lenzkes on the Blood Test That Best Predicts How Long You'll Live

Financial Sense(R) Newshour

Play Episode Listen Later Aug 11, 2026 42:01


Aug 10, 2026 – Can longevity really be measured and improved? In this eye-opening interview, Jim Puplava sits down with Dr. Brian Lenzkes to break down the results of his MVX Plus longevity blood test after completing an intensive biohacking regimen...

Financial Sense(R) Newshour
David Trainer Called Oracle's Collapse—Now He's Warning About AI's Biggest Blind Spot (Preview)

Financial Sense(R) Newshour

Play Episode Listen Later Aug 11, 2026 3:53


Aug 11, 2026 – Could AI be quietly steering your money into the next Enron? New Constructs CEO David Trainer reveals why the AI everyone's using for stock picks is dangerously blind—chasing hype while missing the accounting time bombs that sink...

Financial Sense(R) Newshour
Chris Martenson: The "Mystery Seller" Secretly Crushing Oil Prices

Financial Sense(R) Newshour

Play Episode Listen Later Aug 8, 2026 36:00


Aug 7, 2026 – Chris Martenson of Peak Prosperity joins Jim Puplava to expose the "mystery seller" crushing oil prices in thin overnight futures markets—and why it can't last. From plunging Cushing and SPR inventories to surging diesel crack...

Financial Sense(R) Newshour
Renewed Dollar Weakness Ignites Precious Metals Rally, Says Chris Puplava

Financial Sense(R) Newshour

Play Episode Listen Later Aug 8, 2026 18:54


Aug 7, 2026 – Chris Puplava highlights recent catalysts behind the rally in gold and silver, including yen intervention, a weak jobs report, and broad-based dollar weakness. He notes China's aggressive gold buying, a shift in the U.S. labor market toward...

Financial Sense(R) Newshour
Greg Weldon: Metals Surge, Dollar Reversal, and Super El Niño

Financial Sense(R) Newshour

Play Episode Listen Later Aug 7, 2026 30:37


Aug 7, 2026 – Greg Weldon, publisher of the Global Macro Strategy Report, discusses gold and silver's surge this week, signaling renewed momentum for precious metals as the U.S. dollar weakens. Greg also explains how forecasts for a Super El Nino...

Financial Sense(R) Newshour
This Week's Market Wrap: AI Evolving, Labor Softening, and Broadening Rally

Financial Sense(R) Newshour

Play Episode Listen Later Aug 7, 2026 21:13


Aug 7, 2026 – Earnings continue to support the AI infrastructure cycle. The labor market is slowing without clear evidence of recession. The Nasdaq repaired what now looks like a failed breakdown. Breadth remains healthy, and global technology...