Podcasts about Orr

Episode OverviewFor the second time in two decades, a phase 3 trial has shown a statistically significant improvement over R-CHOP in newly diagnosed diffuse large B-cell lymphoma (DLBCL). In this episode, Eddie, Raj, and Ashwin sit down with Professor Charles Herbaux to unpack the data, debate the clinical implications, and ask the question that's on every hematologist's mind: is this enough to change practice?Background: Setting the Stage for TafasitamabBefore diving into frontMIND, the episode provides context on tafasitamab, a CD19-targeting monoclonal antibodyL-MIND (Phase 2 — relapsed/refractory DLBCL):81 patients with R/R DLBCLORR 58%, complete response rate 41%Established activity of tafasitamab + lenalidomide in the relapsed settinghttps://pubmed.ncbi.nlm.nih.gov/32511983/First-MIND (Phase 1b — frontline DLBCL, IPI 2–5):66 patients randomized: tafa-R-CHOP (n=33) vs. tafa-len-R-CHOP (n=33)ORR: 75.8% vs. 81.8%, respectivelySerious treatment-emergent adverse events: 42.4% vs. 51.5%Provided the signal (and the safety caution) to move to phase 3https://pubmed.ncbi.nlm.nih.gov/37369099/The frontMIND TrialDesign: Phase 3, double-blind, placebo-controlled randomized trialIntervention: R-CHOP + tafasitamab (12 mg/kg IV days 1, 8, 15 per cycle) + lenalidomide (25 mg/day, days 1–10 per cycle)Control: R-CHOP + placebosGCSF mandatory (given double-blind design); VTE prophylaxis (heparin or aspirin) mandatory given lenalidomideEnrollment: May 2021 – March 2023; 899 patients randomizedPrimary endpoint: Investigator-assessed progression-free survival (PFS)Patient Population:Age 18–80; DLBCL or high-grade B-cell lymphoma, IPI 3–5Median age: 65 years96% advanced stage; 54% bulky disease; 31% ECOG PS 2; 82% elevated LDH55% IPI 3 / aaIPI 2; 43% IPI 4–5 / aaIPI 38% double/triple hit — a high-risk subgroup included despite R-CHOP being the controlBroad histologic inclusion: transformed lymphoma, grade 3B FL, T-cell/histiocyte-rich LBCL, EBV+ DLBCL, ALK+ LBCL, HHV8+ DLBCL Note: On retrospective central review, ~7% of patients had a different histology (roughly half had FL grade 1–3A), underscoring the diagnostic challenges in DLBCL~40% received pre-phase steroids; 8% rituximab; 4% vincristine prior to cycle 1Key Efficacy Results(Primary analysis at median follow-up 35.2 months) | Endpoint | Tafa-Len-R-CHOP | R-CHOP | HR / p-value | 2-year PFS | 71.1% | 62.9% | HR 0.75, p=0.0194 | 3-year PFS | 67.3% | 60.7% | ~6.6% absolute difference | Overall Survival | — | — | HR 0.85, p=0.27 (immature)Points of Discussion:Absolute PFS benefit at 2 years: ~8.2%; at 3 years: ~6.6% — a modest but statistically significant improvementOS curves cross early, then separate slightly from ~18 months; data remain immatureEarly censoring observed: ~17% (intervention) and ~14% (control) censored by 9 months — raises questions about off-protocol therapySubgroup consistency: PFS benefit appeared consistent across prespecified subgroups; specific subgroups discussed in the episodeSafety Adverse Event | Tafa-Len-R-CHOP | R-CHOP | Fatal treatment-emergent AEs | 6% (26 pts) | 4% (17 pts) | Diarrhea (any grade) | 25% | 17% | Febrile neutropenia | 17% (incl. 1 death) | 13% | Grade ≥3 anemia | 24% | 17% | Grade ≥3 thrombocytopenia | 27% | 14%The addition of tafasitamab and lenalidomide to R-CHOP adds meaningful hematologic toxicity, particularly thrombocytopenia and anemia, as well as diarrhea and febrile neutropenia.Key Discussion Points from the EpisodeDid the early-phase L-MIND and First-MIND data justify bringing tafasitamab into the front-line setting, and was tafa-len-R-CHOP the right intervention arm to take forward?Is R-CHOP the appropriate control for a patient population that includes 8% double/triple hit lymphoma?What are the implications of using investigator-assessed PFS as the primary endpoint — and how critical is effective blinding to the integrity of that endpoint?How do we interpret the early OS curve crossing and currently non-significant OS benefit?Is the ~8% absolute PFS improvement at 2 years clinically meaningful enough to change practice — particularly given the added toxicity?How should we think about patient selection: who would you prioritize for tafa-len-R-CHOP over standard R-CHOP in clinical practice?What does frontMIND mean for the DLBCL treatment landscape alongside polatuzumab-R-CHP (POLARIX)?Resources & Further ReadingfrontMIND trial: Lenz et al. Lancet. https://pubmed.ncbi.nlm.nih.gov/42217458/POLARIX: Tilly H, et al. NEJM 2022About BloodCancerTalksBloodCancerTalks is a medical education podcast hosted by Raj, Ashwin, and Eddie, dedicated to the latest advances in hematologic malignancies. New episodes available wherever you listen to podcasts.Follow us on X/Twitter for episode updates and hematology/oncology content. 

Our discourse today centers on the illustrious yet oft-overlooked figure of Charles C. Diggs, Jr., whose life and political career encapsulate the essence of African American representation and advocacy in the United States Congress. We are privileged to engage with Professor Marion Orr, an esteemed scholar whose latest work, "House of Diggs: The Rise and Fall of America's Most Consequential Black Congressman," meticulously chronicles the profound impact of Diggs on civil rights legislation and U.S. foreign policy regarding Africa during a pivotal era. With a narrative rich in historical context, we unearth the complexities of Diggs's contributions, which extend far beyond his significant achievements to include the struggles and adversities he faced as a pioneering leader amidst societal upheaval. Through our conversation, we shall delve into the nuances of his legacy, exploring not only the remarkable triumphs but also the unfortunate scandal that marred his later years. Join us as we navigate the intricate tapestry of Diggs's life, illuminating lessons pertinent to the ongoing discourse on black political power and representation today. A profound exploration of the life and legacy of Charles C. Diggs, Jr. unfolds within the latest installment of Becoming Bridge Builders. The episode features a riveting conversation with Professor Marion Orr, whose recent biography, 'House of Diggs: The Rise and Fall of America's Most Consequential Black Congressman,' delves into the historical significance of Diggs, the first African American congressman from Michigan. Professor Orr articulates how Diggs not only navigated the treacherous waters of mid-20th century American politics but also became a pivotal figure in the civil rights movement, advocating tirelessly for legislative reforms and African American representation. Through his life story, we are confronted with the complexities of political power, the necessity of solidarity among Black leaders, and the courage required to challenge systemic injustice. As Diggs' narrative unfolds, listeners are invited to reflect on the intersections of race, politics, and history, gaining insights that resonate profoundly in today's sociopolitical landscape.Takeaways:The podcast underscores the significance of Charles C. Diggs, Jr.'s contributions to civil rights and political representation, illustrating how his legacy is often overlooked despite its profound impact on American history.Professor Marion Orr elucidates the circumstances surrounding Diggs's life, emphasizing his pioneering role in the establishment of the Congressional Black Caucus and his enduring influence on U.S. African policy.The conversation highlights the intersection of education and activism, as both Diggs and Orr stress the importance of perseverance and courage in the face of systemic challenges in American politics.In discussing Diggs's indelible mark on civil rights legislation, the podcast reveals how his actions, notably during the Emmett Till trial, exemplified unwavering commitment to justice and equality.Orr's insights present a nuanced understanding of the pressures faced by early black legislators, shedding light on the formidable obstacles and societal expectations that shaped their political journeys.Ultimately, the dialogue serves as a compelling reminder of the necessity for courageous leaders in contemporary politics, advocating for tenacity in the pursuit of social justice and equity.Links referenced in this episode:marionor.comuncpress.comamazon.comMentioned in this episode:My friend Dr. Noah St. John calls this 'the invisible brake.' He's giving our listeners a free Revenue Ceiling Audit to help you see what's REALLY holding you back. You'll also get a FREE 30-day membership to Noah Bot, giving you access to Dr. Noah's 30 years of experience to help you reach your next level. But hurry, because there are only 50 available this month. So if you're tired of being stuck at the same revenue level and want to finally break through, get your FREE Revenue Ceiling Audit at https://www.noahvault.com?aff=d28bf6c78150c7f09896297dfe1701c1cd191ac6fc9976779212cec5d38e94d6

PRQ Homesteading Expanded with Ra-bin and ShaneP What is an Open Records Request Part 2 Reclaiming Truth, Peace, and Local Power A Breath, and the Power of “I Am” In this episode of PRQ Homesteading Expanded, host Ra Bin opens with enthusiasm for the show's banjo theme before introducing the title topic: “What Is an ORR? Part Two.” She explains that the conversation continues from the May 30 episode and returns to the advocacy playbook after a previous caller, Travis from Real Estate Mindset, shifted the direction of that earlier show. Ra Bin begins with the phrase “I am,” asking listeners to consider how often those words define reality, identity, limitation, and possibility. She contrasts statements such as “I am tired,” “I am stuck,” and “I am broke” with the spiritual phrase “I am all that I am,” emphasizing that words and thoughts help shape lived experience. Beyond Mindset: Where Identity Meets Paper Trails Ra Bin explains that PRQ Homesteading Expanded is not only about homesteading in the traditional sense, but about truth-seeking, property rights, public records, mortgages, foreclosures, contracts, and personal sovereignty. She says the show is an independent extension of the original PRQ Homestead, focused on what is really happening in people's daily realities. Her message is that just as people must examine the words they use to define themselves, they must also examine the records, contracts, and institutional documents that define the systems around them. For Ra Bin, freedom begins when fear ends and knowledge begins. Wellness, Competition, and the Discipline After the Stage Before moving into public-records advocacy, Ra Bin shares a personal update connected to her recent NPC fitness competition on May 23, which she also identifies as her birthday. She reflects on the discipline required for training, nutrition, cardio, and daily routine, but says the real challenge began after the competition: transitioning back into a sustainable lifestyle while maintaining the habits that helped her grow. She describes improved recovery, strength, energy, and physical evolution, emphasizing that age becomes a limitation only when people accept it as one. She also credits Nano Ojas wellness sprays as part of her daily support for energy, focus, recovery, clarity, and overall vitality. The Disclaimer Before the Deep Dive Ra Bin gives a clear disclaimer that the show is based on personal journey, research, experience, and perspective, and is meant for educational, informational, and inspirational purposes only. She says it should not be taken as legal, financial, tax, medical, or professional advice, and encourages listeners to consult qualified professionals before making major decisions. At the same time, she urges people to go within, trust their inner guidance, practice discernment, and take only what resonates. This sets the tone for the rest of the episode, where she discusses legal and civic issues from a personal advocacy standpoint rather than as professional instruction. Property Taxes, Debt, and the Real Estate Mindset Warning Ra Bin plays and discusses a clip from Real Estate Mindset, featuring commentary by Mitch Vexler about property taxes, school district bonds, debt, banks, subprime lending, and what he describes as systemic fraud. She pauses to explain the meaning of subprime, clarifying that it refers to borrowers with higher credit risk who often receive loans with less favorable terms. She connects the clip to broader concerns about housing, foreclosure, mortgage debt, bankruptcy, and what she believes may become a major financial reckoning. Her purpose is to help listeners understand the terminology behind the claims being discussed so they can better follow the advocacy material. When the Homestead Battle Became a Peace Decision A major personal section of the episode centers on Ra Bin's own homestead and bankruptcy-court journey. She explains that after homesteading her house, she originally believed she was following a path toward freedom, inspired by Q-related guidance about reclaiming one's home and sovereignty. But after months of defending herself in bankruptcy court as a pro se litigant, she came to feel that the process had become overwhelming, complex, and spiritually draining. She says the trustee told her most pro se litigants do not make it through bankruptcy court and questioned why she did not have an attorney. Ra Bin explains that she eventually chose to walk away from the house, not as defeat, but as a decision to reclaim peace over pride. Letting Go of the House Without Losing the Self Ra Bin reflects deeply on the difference between surrender and wisdom. She says there comes a moment when a person must ask whether a path is still serving their highest good. When stress steals joy, uncertainty creates constant tension, and the spirit feels heavy, she says it may be time to choose a different direction. She emphasizes that no house, possession, or physical structure is worth losing oneself over. The address may change, but the spirit remains. For listeners facing difficult decisions, Ra Bin encourages trusting intuition, honoring peace, blessing the lesson, releasing the struggle, and remembering that true home has always been within. The Mortgage Paper Trail and the Next Court Step Although Ra Bin has left the house, she says the matter is not entirely finished. She explains that she is still scheduled to appear before a state and local judge in Muskegon County in connection with the eviction process. She also says that while moving, she found a document from Mortgage One, sent one month after she purchased the house, stating that LoanCare would become the new servicing company, but not stating that MSHDA was the new owner. She presents this as another piece of evidence and says she created several open records requests connected to the matter, hoping the judge may allow more time for those records to be produced and reviewed. Allegations, Advocacy, and a Plea for Investigation Ra Bin then plays another clip from Real Estate Mindset, this time involving Kayla and Travis, discussing alleged property-tax-related criminal enterprises, arrests, threats, and racketeering claims in Godley, Texas. Ra Bin uses the clip to argue that local corruption is not limited to one town or one state. She then shares a serious concern about a friend in Texas whom she says was helping expose wrongdoing and was later arrested on what she describes as a bogus old charge. She alleges that he and others are being mistreated in a large prison facility and asks anyone with authority to investigate. She speaks emotionally but frames her plea as a call for help, accountability, and protection of people she believes are being silenced. What an ORR Is Really For: Evidence, Not Emotion Returning to the advocacy playbook, Ra Bin explains that an ORR, or open records request, is a tool for obtaining documents, communications, contracts, and meeting records from public institutions. She stresses the importance of documentation: cameras, emails, screenshots, organized records, deadlines, and professional follow-up. She says documentation turns opinions into evidence. She also shares that she filed open records requests with the local county sheriff's department, the register of deeds, and Mortgage One, seeking mortgage records, assignments, sheriff's deeds, corrections, amendments, and related instruments. For Ra Bin, the ORR process is one way ordinary people can verify facts instead of relying on rumor or hearsay. The Advocacy Playbook: Small Groups, Steady Pressure, Real Change Ra Bin summarizes the first Real Estate Mindset advocacy playbook, saying that real change does not always begin in Washington, D.C., or state capitals, but often begins with three or four committed people paying attention locally. She emphasizes attending city council, county commission, courthouse, township, and school board meetings. The rules she highlights include bringing a camera when legally allowed, learning open-records laws, staying unemotional, telling facts clearly, building relationships, showing up consistently, and using social media responsibly. She warns against trying to do everything alone, failing to document, acting before researching, quitting after the first setback, or alienating the people one is trying to help. Defend, Don't Fight: The Emotional Cost of Local Battles Throughout the advocacy discussion, Ra Bin distinguishes between fighting and defending. She says fighting became too draining for her, while defending is different because it can be done from a calmer, more grounded place. She advises listeners to know the language, understand relevant laws and codes, and remain factual when entering courts or public meetings. She also recounts another homesteading-related court situation in Michigan where emotion appeared to be used against participants. Her larger message is that people must remain centered, informed, and steady, because local accountability work can become emotionally exhausting if it is not grounded in peace and preparation. Four Ordinary People and the Conroe Example Near the end, Ra Bin reads a powerful letter from Travis about a local advocacy victory in Conroe, where he describes four ordinary people standing up to a city council that would not listen. The letter recounts rallies, emails, videos, criminal complaints, public pressure, and eventually an election in which four citizens were swept into office. According to the letter, those new officials repealed an ordinance and helped bring vendors, small businesses, festivals, markets, and life back to downtown Conroe. Ra Bin presents the story as proof that ordinary people do not need money, titles, or permission to make change; they need truth, persistence, documentation, and a few people willing to hold the line together. Closing the Circle: Knowledge, Stillness, and One Informed Step Ra Bin closes by reminding listeners that real freedom begins with knowledge, responsibility, and the courage to ask questions. Whether the issue is homesteading, mortgages, foreclosures, public records, local government, or spiritual discernment, she says people should never underestimate the power of an informed and engaged human being. She encourages listeners to step away from noise, spend time in quiet reflection, connect with the land, listen to intuition, and seek internal stillness. Her final message is to stay grounded, stay curious, keep learning, and build the future one informed step at a time.

Connor Orr of Sports Illustrated released a list of 100 bold predictions for the 2026 NFL season, highlighted by a surprising forecast that has an unexpected team knocking off the Seattle Seahawks in the Super Bowl. Chris Russell dives into Orr's predictions, examining which projections are realistic, which ones seem far-fetched, and where the Washington Commanders fit into the overall outlook for the season. Russell reacts to several of the most eye-catching predictions on the list, weighing the likelihood of major upsets, breakout teams, and unexpected storylines while discussing whether Washington is receiving too much respect, not enough respect, or exactly the right amount of attention heading into the year.

The final hour begins with a humorous story involving two San Antonio women before Chris Russell dives into Connor Orr's list of 100 bold predictions for the 2026 NFL season, including a surprising Super Bowl champion picked over the Seahawks, and examines where the Commanders fit into Orr's forecast for the year ahead. The conversation continues with a closer look at Washington's outlook and how the Commanders stack up against some of the league's most intriguing storylines entering the season. The hour wraps up with listener calls and final reactions to the ongoing debate surrounding the Commanders' return to Washington, D.C., as fans weigh in on the RFK Stadium site, the future of the franchise, and what a move back into the city would mean for the team and its supporters.

Over 25 years since the UK's first open access passenger rail service, and the subject still divides opinion. Those for point to services to communities that had been forgotten, competition driving down prices as well as stimulating. Those against point to revenue abstraction not outweighed by the growth and to adding serious performance challenges on an already congested network. One person who has led the charge for Open Access and has been unquestionably successful in the process is Ian Yeowart. He is tenacious, focused and very experienced. Ian's latest venture though, the running of services between Marchwood on a reopened Waterside branch, through Southampton, Winchester and Basingstoke to London Waterloo has been comprehensively rejected by the ORR – and he's not best pleased. I caught up with Ian to hear his views and he is characteristically forthright in his opinions.Membership: If you want to see even more from Green Signals, including exclusive content, become a member and support the channel further too.YouTube -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@GreenSignals/join⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/GreenSignals⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Green Signals: Website -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merchandise - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://greensignals.etsy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Newsletter -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org/#mailing-list⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow: X (Twitter) -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/greensignallers⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ LinkedIn -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/company/green-signals-productions-ltd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You can view our legal disclaimer, copyright information and privacy policy here - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.greensignals.org/legal/⁠

Love to hear from you; “Send us a Text Message”330,000 missing kids is not a talking point. It's a flashing red warning that something is broken in how the U.S. Deep State handles unaccompanied migrant children, child welfare, and immigration enforcement. We walk through the story of a young teen released from federal custody who ends up working punishing overnight shifts, then widen the lens to the numbers, the incentives, and the institutions that move children through the system.Tom Hampson, a crime investigator and reporter, joins us to explain what he found while investigating ORR placements, trafficking risk, and the role of NGOs that present as “charities” while being funded almost entirely by taxpayer dollars. We talk about what it means when the government acts in loco parentis, why fractured bureaucracy makes responsibility disappear, and how stonewalled FOIA requests keep the public from seeing where the money and the paperwork actually lead.We also put the moral argument on the table, including Catholic social teaching on immigration: welcome where possible, protect the common good, enforce just laws, and never treat vulnerable people as objects in a pipeline. The conversation touches media narratives, church leadership, and the uncomfortable truth that “compassion” can become cover for negligence when no one is forced to answer for outcomes. If you care about border security, human rights, child protection, and government accountability, this one will challenge you.Visit Tom Hampsons Substack: https://thomasrhampson.substack.com/Evangelizing Gen Z!! Join the movement of young men! Claymore milites Christi (Soldiers for Christ) Subscribe for more, share this episode with someone who thinks they already understand the issue, and leave a review with your biggest takeaway.Support the show

Results from the first-in-human, phase 1 MYTHIC trial (NCT04855656) demonstrated that combining the WEE1 inhibitor zedoresertib with the PYKMT1 inhibitor lunresertib achieved an overall response rate (ORR) of 18.5% via RECIST criteria in patients with CCNE1, FBXW7, and PPP2R1A-altered cancers.1 In patients with resistant/refractory ovarian cancer, the ORR was 33.3% across all dose levels and 50% at the potential recommended phase 2 dose. These data were presented by Timothy A. Yap, MBBS, PhD, FRCP, at the 2026 American Association for Cancer Research (AACR) Annual Meeting. Following his presentation, Yap joined CancerNetwork® for a discussion where he highlighted some of the most interesting takeaways from the trial. According to Yap, the disease states evaluated in this trial represent areas of unmet need where no specific standard-of-care options can target these alterations.Notably, based on results from this trial, the FDA granted fast track designation to lunresertib in combination with zedoresertib in patients with genomic-defined platinum-resistant ovarian cancer.2Yap is a medical oncologist and physician-scientist, as well as the Random Horne, Jr. Endowed Professor for Cancer Research and vice president and head of Clinical Development in the Therapeutics Discovery Division at UT MD Anderson Cancer Center.References1.        Yap TA, Aggarwal R, Fontana E, et al. First data disclosure of the Phase I trial of the first in class combination of WEE1 inhibitor zedoresertib with PKMYT1 inhibitor lunresertib in patients with advanced solid tumors harboring CCNE1, FBXW7, or PPP2R1A genomic alterations. Presented at the 2026 AACR Annual Meeting; April 17-22, 2026; San Diego, CA. Abstract CT022.2.        Following oral presentation of phase I Data at AACR 2026, Debiopharm announces FDA fast track designation for lunresertib in combination with zedoresertib for genomic-defined platinum-resistant ovarian cancer. News release. Debiopharm. April 20, 2026. Accessed May 4, 2026. https://shorturl.at/n1bWn

Senator Orr also wishes Dale well and hopes he recovers from his gout soon.See omnystudio.com/listener for privacy information.

Great Western Railway will be nationalised in December… and that much-loved historic green livery will soon disappear HS2's big ‘reset' is delayed AGAIN. Or is it? GB Railfreight's Class 99s take a big leap towards entering serviceAnd… an LNER overspeed incident might have been caused by driver distraction.**Link to download the TicketyBoo app: https://myticketyboo.com/app_download/ Link to TicketyBoo website: https://myticketyboo.com/ Use code GREENSIGNALS5 at checkout to get £5 off your first booking**** Book the Green Signals Jolly to the Keighley & Worth Valley Railway here: ⁠⁠https://www.eventbrite.com/e/green-signals-jolly-to-the-keighley-worth-valley-railway-tickets-1986536021717?aff=oddtdtcreatorIn this episode:(00:00) Intro(01:54) GWR nationalisation date announced(12:24) Is HS2's ‘reset' delayed?(17:45) Railway news round-up(17:52) GSM-R fault causes disruption(18:33) Oxley freight derailment(19:32) British Steel to be nationalised(20:03) Severn Tunnel major work(21:08) Mid Cornwall Metro launch(21:53) ORR rejects Grand Union open access application(24:23) Class 99s gain Statement of Compatibility(30:17) Grantham overspeed caused by ‘driver distraction'?(36:26) South West weather resilience video teaser(42:10) Heritage news round-up(42:19) East Lancs graffiti attack(42:52) Vale of Rheidol Railway Prince of Wales oil conversion(44:06) Talyllyn Railway celebrates 75thanniversary(44:53) Severn Valley Railway platform extension(45:55) Avon Valley Railway £150k fundraising appeal(46:43) Kent & East Sussex Railway Morning Bird-Song Tours(47:32) Museum of Scottish Railways new exhibition(48:35) Thanks to Supporters(50:36) The Quiz(55:24) Wabtec Doncaster Open DayMembership: If you want to see even more from Green Signals, including exclusive content, become a member and support the channel further too.YouTube -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@GreenSignals/join⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/GreenSignals⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Green Signals: Website -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merchandise - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://greensignals.etsy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Newsletter -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org/#mailing-list⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow: X (Twitter) -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/greensignallers⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ LinkedIn -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/company/green-signals-productions-ltd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You can view our legal disclaimer, copyright information and privacy policy here - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.greensignals.org/legal/⁠

In today's episode, we welcomed Luhua (Michael) Wang, MD, to discuss the implications of the full FDA approval of brexucabtagene autoleucel (Tecartus; brexu-cel) for the treatment of adult patients with relapsed/refractory mantle cell lymphoma (MCL). Dr Wang is a professor in the Department of Lymphoma/Myeloma in the Division of Cancer Medicine, as well as a professor in the Department of Stem Cell Transplantation at The University of Texas MD Anderson Cancer Center in Houston.On April 2, 2026, the FDA granted traditional approval to brexu-cel based on data from the phase 2 ZUMA-2 trial (cohorts 1 and 2, NCT02601313; cohort 3, NCT04880434), with confirmatory data from cohort 3 showing that patients naive to a BTK inhibitor experienced an overall response rate (ORR) of 91% (95% CI, 82.5%-95.9%), a complete response (CR) rate of 79% (95% CI, 69.0%-87.1%), and a median duration of response (DOR) that was not reached (NR; 95% CI, 26.2 months-not evaluable).Dr Wang detailed the evolution of therapies in the MCL treatment paradigm, leading up to the approval of brexu-cel and the integration of CAR T-cell therapy. Along with highlighting the evolution of MCL management, Dr Wang explained how data from cohort 3 of ZUMA-2 add further context to the role of CAR T-cell therapy in the treatment paradigm and how it may affect treatment sequencing considerations.

Orr v. Trump

We can thank the new Reserve Bank Governor for ending the week on a high note. New charter details were announced yesterday. Charters and Reserve Banks were once as dry as old dust but these days I think we have a new understanding of the importance of their role. Out of Covid and economic shambles has come more talk than ever about cash rates and inflation and debt and wasteful expenditure. The main change for me is the Monetary Policy votes will be made public, and not a moment too soon. They are already starting to hold press conferences after each decision. Some decisions are statements, some are reviews and, as such, carry different amounts of detail and information. But the idea that they front after each decision shouldn't be new. It should have always happened. Just what was it about the thinking at the lower end of the terrace in the capital that had them believing that simply putting out a statement was plenty. Why wouldn't they want questions? Why wouldn't they want to be held to account? Given everything is streamed these days you can watch it all. There's no need for a journalist to cut and paste a few so-called highlights to skew the narrative. Free and open and complete accountability should be welcomed, and this is overdue. But as for the vote, the same thinking applies. If you hold the power of a committee member and if you get a say in a mechanism as important as the country's cash rate, once again, what's your argument for remaining quiet? To keep it a secret? If the vote is 5-1, who is the one and why? What's wrong with an explanation? For example, there were four dissenting votes yesterday at the Fed. Let's hear about it. Knowledge is power and the fact we are only at this place in 2026 is a crime of sorts. A condescending attitude where they clearly thought we didn't need to know. So far new Governor Dr Anna Breman has introduced pressers, changed the charter and promised to at least partially look through the immediate inflationary impact of the war. So far, so impressive. I like the cut of her gib. Orr vs Breman? No contest. See omnystudio.com/listener for privacy information.

Few railway organisations have witnessed as much change in their role and structure over the past 30 years as the Office of Rail and Road (ORR). This, despite being a constant feature of the landscape. And yet the next few years will bring about the biggest changes so far in their role.John Larkinson has been CEO for over 7 years, the culmination of a long and distinguished career in the railway industry. At the end of April 2026, John retires, a pivotal moment for him personally and the industry at large.Green Signals sat down with John recently to chat about his career, his time at the SRA, at the ORR and the highs lows of all that, including his views on rail reform and hopes for the future. It's a very personal discussion and one that anyone interested in the extraordinary period since privatisation of the railway till now will find hugely interesting.Membership: If you want to see even more from Green Signals, including exclusive content, become a member and support the channel further too.YouTube -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@GreenSignals/join⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/GreenSignals⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Green Signals: Website -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merchandise - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://greensignals.etsy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Newsletter -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.greensignals.org/#mailing-list⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow: X (Twitter) -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/greensignallers⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ LinkedIn -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/company/green-signals-productions-ltd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You can view our legal disclaimer, copyright information and privacy policy here - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.greensignals.org/legal/⁠

In the final hour, Sports Illustrated reporter Conor Orr joins DVD to discuss all things NFL, the NFL Draft, Jeremiyah Love's story, the Titans, and more. They reacted to what they heard from Orr, more Titans talk, and discussed what happened during the Stanley Cup Playoffs

In this replay episode of Grow Everything, Karl and Erum catch up after recent travel, reflect on a standout mainstream biotech article about biology reshaping the global chemical industry, and discuss why “tissue-on-a-chip” experiments in space matter for long-duration missions. They then kick off a deeper dive into bio-based dyes by revisiting their interview with Orr Yarkoni, co-founder and CEO of Colorifix, who explains how engineered microbes can both produce and directly deposit pigment onto textiles to dramatically reduce toxic chemistry, water use, and energy demand compared to conventional dyeing. The conversation covers why black and high-performance reds remain the hardest colors to replace, how Colorifix approaches scale-up through distributed on-site fermentation hardware, and what it takes to meet the real-world fastness and safety standards that brands and mills require.Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Chapters:(00:00:00) Travel catch-up and what the hosts have been thinking about lately(00:05:30) Mainstream biotech gets it right: biology as “Mother Nature's R&D lab” for the chemical industry(00:07:15) Artemis and why deep-space biology experiments matter(00:08:40) Project Hail Mary and communicating across radically different biology(00:12:55) Why this season is focusing on bio dyes, and why textiles are a key wedge industry(00:16:55) Interview begins: Orr's background and the pivot from arsenic biosensing to dyeing(00:20:15) How conventional textile dyeing works, and why it is so chemically and water intensive(00:24:10) What Colorifix does differently: microbes that make dye and fix it onto fabric(00:27:10) Performance realities: lightfastness, washfastness, and why “green but fragile” is not sustainability(00:29:35) Finding pigments in nature, choosing the right biosynthetic routes, and translating them across materials(00:34:20) Who buys what: dye houses, mills, and how the business model works(00:36:55) Scaling fermentation the hard way: standardizing hardware and enabling on-site production(00:40:05) Hardware basics and the economics of bioreactors for commodity chemicals(00:44:05) Worker health, safer chemistry, and toxicity testing across the full process(00:46:05) Where you can find Colorifix in-market, and which materials are trending(00:49:00) Color priorities: why blue is easiest, and why black is the biggest challenge(00:51:15) Regulation tailwinds: why some black chemistries are being phased out(00:55:15) The future: bio-manufacturing everyday goods at scale(00:58:45) Orr's film recommendation: The Man in the White Suit(01:00:00) Closing: upcoming live recording at DC Climate Week and SynBioBetaLinks and Resources:Colorifix 75. Dye Another Day: The New Way to Color Textiles with Colorifix's Orr YarkoniTracking the removal of Petroleum-based Food Dyes Food Safety and Health Concerns of Synthetic Food DyesNational Geographic Spider SilkArtemis Mission - Lunar FlybyDC Climate WeekSynBioBeta Pass - Discount code: Grow Everything Topics Covered:industrial biotech, synthetic biology, biomanufacturing, microbial fermentation, engineered microbes, sustainable textiles, bio-based dyes, textile dyeing process, green chemistryHave a question or comment? Message us here:Text or Call (804) 505-5553⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠Youtube⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠Grow Everything⁠⁠⁠⁠⁠⁠⁠⁠Music by: Nihilore Production by: Amplafy Media

This week on the Faculty Factory Podcast, Heather Whelan, MD examines the health risks of a changing world and their implications for medical education and academic medicine. Dr. Whelan serves as Director, Climate Ambassador Program, UC Center for Climate, Health and Equity with University of California, San Francisco (UCSF). "Healthcare professionals are among the most trusted people to talk about climate change with the public. We can take advantage of that opportunity to educate and inquire about how climate change is affecting people,”  Dr. Whelan said at the end of the interview. Here are some of the links from today's conversation with Dr. Whelan that we encourage you to visit: Dr. Whelan's Podcast called Climate Crossing Info on UC Climate Ambassador Program Climate Ambassador Resources google drive link Dr. Whelan is a colleague of past Faculty Factory Podcast guest, Andrew Orr, MD, MSEd. We are grateful to Dr. Orr for making the introduction to her as a referral to us for this interview! You can revisit the interview with Dr. Orr about How Introverts Can Excel in Academic Medicine. As a side note, please feel free to send us your recommendations for a future guest by emailing the show through visiting this link and send us a quick note of who you'd like to nominate and why.

Interviewer: MATTHEW ROTH. The ways in which the Civil Rights Movement translated passion and protest into durable political change were complex, involving a wide range of actors beyond those most prominently enshrined in the popular imagination. In his new book, political scientist MARION ORR argues for the critical importance of a figure now widely forgotten: Michigan Congressman Charles C. Diggs, Jr., who during his tenure from 1955-1980 was a persistent and effective voice for desegregation and Black self-determination. In his discussion with historian Matthew Roth, Orr describes Diggs' roots in his Detroit family's funeral home, the House of Diggs; his political career as a pathbreaking Black Michigan Senator and then U.S. Congressman; his accomplishments, ranging from the desegregation of airline travel and Washington D.C. home rule to the founding of both the Congressional Black Caucus and institutions critical to the anti-Apartheid movement; and finally, to his downfall with a criminal conviction for the financial mismanagement of his congressional office. Orr's book is House of Diggs: The Rise and Fall of America's Most Consequential Black Congressman, Charles C. Diggs Jr.

Public health nurses are on the front lines of community health but many are facing stress, burnout, and limited opportunities for advancement. In this episode Shirley Orr, executive director for the Association of Public Health Nurses, talks about the final session in the Public Health Nursing Workforce Learning Lab series and what it reveals about retaining the public health nursing workforce. Drawing on insights from the Association of Public Health Nurses and the Public Health Workforce Interests and Needs Survey (PH WINS), Orr discusses why about a quarter of public health nurses say they may leave the field, and what leaders can do about it. From fostering supportive workplace cultures and strong supervision to creating clear pathways for professional development and shared decision-making, the conversation highlights practical strategies agencies can use to improve satisfaction and keep nurses engaged.Meeting Home PageASTHO (@astho) on X⁠, Bluesky, Instagram, LinkedIn, ⁠Facebook

Episode 315 of UnSpun with Jody Vance and George Affleck goes from a Vancouver City Hall apology tour to the end of daylight saving time to an actual war breaking out in the Middle East.Here's what's inside:

Tune in Friday, February 27, 2026 @ 7pm EST/4pm PST/6pm CST for the next “He Said, He Said, He Said Live!” A Look at the World from A Seasoned Black Man's Perspective…because one perspective isn't enough!” for “Immigration,Deportation, and the Law: Separating Fact, Fear, and Freedom with Allen Orr.”As Black History Month ends, He Said, He Said, He SaidLive tackles one of the most urgent and divisive issues shaping America today: “Immigration, Deportation, and the Law: Separating Fact, Fear, and Freedom”Across the country, communities are feeling the impactof aggressive immigration enforcement, expanded detention efforts, and controversial actions carried out by ICE. Families are being separated. Workers are being detained. Fear is spreading through marginalized communities —particularly communities of color.But what is lawful? What is political? And what ishappening beyond public understanding?Joining us is nationally recognized immigration attorney Allen Orr Jr., founder of Orr Immigration Law Firm, P.C., formerPresident of the American Immigration Lawyers Association, and a leading voice in employer immigration compliance and federal immigration policy reform. From overseeing massive I-9 audits for Fortune 10 corporations to influencingDepartment of Labor policy and the PERM rule, Mr. Orr brings clarity, authority, and legal insight into a conversation too often driven by fear instead of facts.This Friday, we examine: The legal limits of ICE enforcement. What rights individuals have. How deportation policies are impacting Black and Brown communities. What freedomand due process truly mean under U.S. law.We close out Black History Month by confronting systems that continue to shape the lives of marginalized people in America.This is not just a conversation. It's clarity in a climate of confusion.New Episodes of “He Said, He Said, He Said” - Live stream Fridays, 7 p.m. EST on all these links: https://linktr.ee/hesaidhesaidhesaid FACEBOOK: facebook.com/hesaidhesaidhesaidlive RELIVE and SHARE special moments from "He Said, He Said, He Said" here: SHOW CLIPS youtube.com/channel/https://www.youtube.com/channel/UCV0MtJCazNWVBSaj1JFHITgFOLLOW US —- CLICK LIKE and SUBSCRIBE to us @hesaidhesaidhesaidlive on YouTube and Instagram!#HeSaidHeSaidHeSaid #BlackHistoryMonth #ImmigrationLaw #KnowYourRights #FactVsFear #BlackPress #CivicEngagement #ICE #DueProcess #Allenorr #ICE #Deportation

After a week off, the boys are back at it on a holiday Monday feelin' rested, relaxed and ready to talk some hockey in this extended Riel Day episode!We'll tell you about the 1971-72 Bruins, a squad the seemed to be on the cusp of a dynasty with 3 finals appearances and 2 titles. Lead by the likes of Espo, Orr, Bucyk, Sanderson, Stanfield, McKenzie, Cashman, Westfall and ol' stiched up Gerry Cheevers between the pipes, this team was a real wagon until the league caught up to them, and #4's career was cut short.  They wouldn't drink from Lord Stanley again until beating the Canucks in 2010-11!In the second, we've all sorts of Olympic hockey to touch on as both the Canadian Men's and Women's teams chase gold in Italy. The men's squad has been very business like thus far, and seems primed for a finals appearance provided that the 'tendys hold up.  The women's team has certainly missed Marie Phillip-Poulin up front, but appear to be back on track for a golden matchup vs their rivals from the US.In the third, we recap a great day for hockey at Apuckalypse, plus detail the final week of the GHL season which hits this week.  And co-host Jared talks about heading to Hali for an excellent donair and some Moosehead's action!

In this urgent conversation, immigration attorney Allen Orr—the first Black president of the American Immigration Lawyers Association and founder of Orr Immigration Law Firm—breaks down what's really happening with ICE enforcement across the country.We discuss:The truth behind "Operation Metro Surge" and mass raidsWhy 75,000 people with NO criminal record were arrestedWhat happened to the 2 US citizens killed in MinneapolisChildren are being detained and separated from their familiesThe profit motive behind private detention centersDeaths in ICE custody (32 last year alone)Practical know-your-rights information everyone needs RIGHT NOWWhat to do if ICE shows up at your door, stops you on the street, or pulls you overResources for undocumented folks, DACA/TPS holders, green card holders, and US citizensWhy this affects ALL Black communities—not just immigrantsThe connection between immigration enforcement and voting rightsWhat the "self-deportation" program really meansThe bigger picture: what's the actual endgame?This is information your family needs. Your neighbors need. Your congregation needs.Listen. Share. Protect each other.Become a supporter of this podcast: https://www.spreaker.com/podcast/teach-the-babies-w-dr-david-j-johns--6173854/support.

Podcast host, Alan Skorski, interviewed Dr. Tim Orr, an Evangelical leader, who earned six Masters Degrees, including a Masters in Islam, while studying at the London School of Islam under the tutelage of a Shia Muslim leader. During the interview Dr. Orr spoke of his visit to London on October 7, 2023, and without knowing all the news that was happening in Israel following the Hamas invasion, witnessed horrific antisemitic demonstrations taking place in the streets of London. At the same time, he was watching news from America from his hotel room, and saw almost identical types of rallies and demonstrations that were amongst the most antisemitic he had ever witnessed. These events led him to speak out in support of Israel, while he was still in London, and scheduled to speak to Muslim audiences as an interfaith leader. He said that his speaking engagements were immediately cancelled, and the Shia leaders who had once engaged him began to curse him and tell him they regret ever befriending him. Following October 7th, Dr. Orr wrote; “What I felt most was that the Church there was very weak. And that weakness carried a cost. That disorientation deepened when I watched American and European universities erupt days later with the same slogans and emotional choreography. It was then I realized I was witnessing the expression of a coherent transnational worldview, not a series of isolated events.” On antisemitism and how support for Israel is weaponized against Jews, Dr. Orr has written; Antisemitism persists not only because it is protected, but because institutions and cultures continue to choose it for its usefulness. It offers a ready explanation for failure, resentment, and moral unease. It allows societies under strain to direct judgment outward while preserving a sense of righteousness. And it does this by rendering Jews abstract enough to blame and unreal enough to disregard.When Israel is a symbol, every Israeli action is interpreted negatively, because symbols are judged by their natures, not by circumstances. When Israel uses force, it is not responding to a threat, but revealing its nature. When it exhibits restraint, it is merely biding time, and accused of cruelty by inaction: there is no space for tragedy, since tragedy exists only when two legitimate claims are in conflict, and Israel is denied legitimacy from the outset. Intent is always presumed, and never examined. Condemnation is not a conclusion, but a premise. “Dr. Orr looks at how antisemitism operates in today's political, media, and activist spaces—not just as hatred, but as a system that adapts and hides in plain sight—and how Islamist movements and narratives play a role in spreading it in the West. He brings a clear, evidence-based perspective to topics that are often misunderstood or deliberately blurred. Tim is the author of six books, including his forthcoming Antisemitism Is More Than Hatred—It's a System: How It Works, Why It Persists, and How It Adapts to Every Age.” He is currently offering an online course titled: Architecture of Antisemitism: Structure. not Just Hatred -VIN News Watch the video interview: https://www.youtube.com/watch?v=_f6bE6bTKiE Alan Skorski Reports 29JAN2026 - PODCAST

One of Charlie’s favorite modern thinkers was Dr. James Orr, who has the lonely job of defending Western classics at Cambridge University. Shortly before Charlie’s martyrdom, he and Dr. Orr met in-person to talk about European decline, why the West decided to give up on itself en masse, and what hope exists for a turning of the tide. Watch every episode ad-free on members.charliekirk.com! Get new merch at charliekirkstore.com! Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

One of Charlie’s favorite modern thinkers was Dr. James Orr, who has the lonely job of defending Western classics at Cambridge University. Shortly before Charlie’s martyrdom, he and Dr. Orr met in-person to talk about European decline, why the West decided to give up on itself en masse, and what hope exists for a turning of the tide. Watch every episode ad-free on members.charliekirk.com! Get new merch at charliekirkstore.com! Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

In this JCO Precision Oncology Article Insights episode, host Dr. Harold Nathan Tan summarizes "Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study" by Worden et al.  TRANSCRIPT Harold Nathan Tan: Welcome to JCO Precision Oncology Article Insights, where we explore research that is reshaping our understanding of cancer therapeutics. I'm your host, Harold Nathan Tan, and today's episode centers on the TAPUR study, an analysis that confronts a long-standing assumption in molecular oncology: namely, whether CDKN2A alterations create a therapeutic vulnerability that can be exploited by CDK4/6 inhibition with palbociclib. CDKN2A is one of the most frequently altered tumor suppressors across solid tumors. Its importance lies in its production of two proteins, p16 and p14, which serve as guardians of cell cycle progression. p16 directly inhibits CDK4 and CDK6, preventing phosphorylation of the RB protein and therefore blocking entry into S phase, whereas p14 stabilizes p53 by counteracting MDM2, enabling cells to pause or die in response to oncogenic stress. When CDKN2A is lost or mutated, these dual checkpoints collapse. CDK4/6 activity becomes unchecked, RB remains phosphorylated and inactive, and p53-mediated surveillance is blunted from a mechanistic standpoint. This creates a possible dependency on CDK4/6 signaling that could, in principle, be therapeutically reversed by palbociclib. The TAPUR study is a prospective phase 2 basket study designed to evaluate whether FDA-approved targeted agents can meaningfully benefit patients with advanced treatment-refractory cancers harboring specific genomic alterations. In this analysis, patients were eligible for palbociclib if their tumors carried CDKN2A loss or mutation and retained RB activity. Two cohorts were examined: one consisting of head and neck cancers, and another composed of a broad spectrum of tumor types that collectively shared the CDK2 alteration. The results from the head and neck cancer cohort are particularly intriguing. Among the 28 available patients, the study observed a disease control rate of 40%, surpassing the predefined threshold for a positive signal. Although the objective response rate was low at only 4% with one partial response, the durability of disease stabilization was clinically meaningful. However, the most important insight comes from examining which head and neck tumors benefited. The strongest and most durable disease control occurred in non-squamous malignancies, particularly salivary gland tumors such as adenocarcinoma, adenoid cystic carcinoma, and poorly differentiated parotid tumors, as well as in esthesioneuroblastoma. In contrast, classic head and neck squamous cell carcinoma rarely demonstrated sustained benefit. When progression-free survival was analyzed, non-squamous tumors achieved a median PFS of approximately 20 weeks compared to just eight weeks in squamous tumors. This divergence reflects deep biological differences. Many non-squamous head and neck cancers preserve an intact RB axis and rely on CDK4/6-driven cell cycle control as a core proliferative mechanism. By contrast, squamous tumors tend to accumulate a dense array of co-alterations that weaken or circumvent CDK4/6 dependency. Many squamous tumors also harbor disruptive TP53 mutations, removing essential checkpoint control and allowing the cell to bypass the growth-arresting effects of palbociclib. In other words, even though CDKN2A loss is present, CDK4/6 is no longer the dominant node controlling proliferation in these cancers, and the tumor simply finds other ways to drive cell cycle entry. One of the most thought-provoking findings from the TAPUR study involves esthesioneuroblastoma. Three patients with this rare tumor achieved durable disease control despite the lack of standardized systemic treatment options for this malignancy. Genomic analyses have shown that while esthesioneuroblastoma often carries TP53 or IDH2 mutations, a meaningful subset exhibits alterations in CDKN2A or related cell cycle regulators. The consistency of this disease stabilization observed in TAPUR may reflect a lineage-specific reliance on CDK4/6 signaling, opening the door for future exploration of CDK4/6 inhibitors in this orphan disease. In the histology-pooled cohort, which included 40 available patients across 18 tumor types, palbociclib did not achieve the disease control threshold required to declare activity, with only a disease control rate of 13% and an ORR of 5%. While a few isolated responses occurred, for instance in thymic carcinoma and B-cell lymphoma, the overall disease control rate was 13%, which failed to rise above what might be expected from the natural history of advanced refractory cancers. This outcome reinforces the principle that CDKN2A loss is not a universal predictor of CDK4/6 dependency. Many of the tumors represented in this cohort, such as pancreatic cancer, melanoma, and gastrointestinal malignancies, are well known to evolve multiple compensatory mechanisms that circumvent CDK4/6 as a critical proliferative node. The safety profile of palbociclib was consistent with its known hematologic toxicities. High rates of neutropenia, leukopenia, and thrombocytopenia were observed, along with one treatment-related death due to respiratory failure. In a setting where activity is limited to specific subgroups, these toxicities underscore the importance of careful patient selection and raise the bar for demonstrating clinically meaningful benefit, particularly in heavily pretreated populations. So what do these findings tell us about the broader landscape of precision oncology? First, they remind us that a mutation's functional role is dependent on the cellular and lineage context in which it occurs. CDKN2A loss may accelerate proliferation in many tumors, but the mechanism of that acceleration varies widely, and the degree to which a tumor relies on CDK4/6 signaling is anything but uniform. Second, the findings suggest that palbociclib monotherapy may hold meaningful and durable benefit in the subset of non-squamous head and neck cancers, particularly salivary gland malignancies and esthesioneuroblastoma. Third and perhaps most importantly, the results reinforce a growing consensus that the future of CDK4/6 inhibition in solid tumors lies not in monotherapy, but in rational combination strategies. CDK4/6 inhibitors have been shown to synergize with EGFR inhibitors, PIK3CA, and mTOR inhibitors, MEK inhibition, and even immune checkpoint blockade. These combinations aim to dismantle the compensatory pathways that allow tumors to escape CDK4/6 blockade and may unlock therapeutic potential in tumors that show limited sensitivity to monotherapy. Ultimately, the TAPUR findings challenge the notion that CDKN2A is a straightforward predictive biomarker. Instead, the study reveals CDKN2A as a biomarker whose meaning is modulated by tumor lineage, co-mutation status, and the broader regulatory circuit governing proliferation. Precision oncology must therefore move beyond single-gene interpretation towards integrated frameworks that situate genomic alterations within their biologic ecosystems. In some head and neck cancer subtypes, particularly non-squamous malignancies, that ecosystem appears amenable to CDK4/6 inhibition, and that insight, not the simplistic gene-to-drug match, represents the true value of the TAPUR analysis. Thank you for joining me for this episode of JCO Precision Oncology Article Insights. I'm Harold Nathan Tan, and I look forward to exploring more research that continues to refine how we understand and strategically exploit the vulnerabilities of cancer. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.      

The world of prehospital medicine is constantly evolving, driven by new research, technological advancements, and a shared commitment to improving patient care and provider well-being. As EMS professionals, staying informed about these developments goes beyond a professional obligation; it is an opportunity to improve our practice, champion our profession, and ultimately make a greater impact on saving lives. In this article, we will explore some of the latest research findings that are reshaping our field, from workplace culture to cutting-edge technology.   The Culture of Care: Supporting EMS Providers Our work is demanding, both physically and emotionally, and the culture within our agencies plays a critical role in our well-being. A recent systematic review in the International Journal of Environmental Research and Public Health revealed that many EMS providers avoid using organizational mental health services due to stigma and a perception that these programs lack genuine care. The study emphasizes the need for person-centered support and a cultural shift that normalizes seeking help as a sign of strength (Johnston et al., 2025). This cultural component also impacts retention. Another study in the same journal found that agencies with collaborative, team-oriented "clan" cultures had significantly lower turnover rates compared to those with rigid or chaotic structures. For leaders in EMS, fostering a supportive environment is not just about morale. It is a strategic imperative for retaining skilled clinicians (Kamholz et al., 2025).   Professional Recognition: Breaking Barriers Across the globe, paramedics are striving for recognition as integrated healthcare professionals. A qualitative study in BMC Health Services Research identified common barriers, including outdated legislation, inconsistent regulation, and insufficient funding. While the pandemic temporarily highlighted our capabilities, the momentum has waned. The study calls for targeted policy reforms and investments in education and leadership to solidify our role in the broader healthcare system (Feerick et al., 2025). Physical Demands and Injury Prevention The physical toll of our work is undeniable. A scoping review in Applied Ergonomics confirmed that musculoskeletal injuries, particularly to the back, are rampant in EMS. Tasks like handling stretchers and patient extractions are among the most strenuous. The review also highlighted fitness disparities, with male paramedics generally showing more strength but less flexibility than their female counterparts. These findings underscore the need for targeted injury prevention programs and realistic physical standards to keep us safe throughout our careers (Marsh et al., 2025).   Advancements in Cardiac Arrest Care When it comes to cardiac arrest, every second counts. A study in Resuscitation reinforced the value of bystander CPR, showing that dispatcher-assisted CPR significantly improves outcomes for untrained bystanders. For those with prior CPR training, acting independently yielded even better results. This highlights the importance of public CPR education alongside dispatcher support (Tagami et al., 2025). On the scene, our interventions matter immensely. Research in The Journal of Emergency Medicine found that for traumatic cardiac arrest patients, aggressive interventions like prehospital thoracostomy can be lifesaving (McWilliam et al., 2025). Meanwhile, a study in Critical Care Medicine revealed that extracorporeal CPR (ECPR) significantly improves outcomes for patients with refractory ventricular fibrillation, emphasizing the need for early transport to specialized centers.   The Role of Technology in EMS Technology is poised to revolutionize EMS, from dispatch to diagnosis. A study in The American Journal of Emergency Medicine demonstrated that large language models (LLMs) like ChatGPT could prioritize ambulance requests with remarkable accuracy, aligning with expert paramedic decisions over 76 percent of the time. This proof of concept suggests that AI could one day enhance resource allocation in dispatch centers (Shekhar et al., 2025). On the diagnostic front, machine learning is opening new possibilities. For example, a study in Bioengineering showed that analyzing photoplethysmography waveforms could estimate blood loss in trauma patients, offering a non-invasive way to guide resuscitation (Gonzalez et al., 2025). Similarly, research in Medical Engineering & Physics explored using multidimensional data to differentiate ischemic from hemorrhagic strokes in the field, potentially enabling more targeted prehospital care (Alshehri et al., 2025).   Addressing Disparities in Care Equity in EMS is a cornerstone of our profession, yet recent studies highlight troubling disparities. Research in JAMA Network Open found that ambulance offload times were significantly longer in communities with higher proportions of Black residents (Zhou et al., 2025). Another study in JAMA Surgery revealed that Black and Asian trauma patients were less likely to receive helicopter transport compared to White patients. These findings are a call to action for all of us to examine our systems and biases to ensure equitable care for every patient (Mpody et al., 2025).   Looking Ahead The research discussed here represents just a fraction of the advancements shaping EMS today. From improving workplace culture and injury prevention to leveraging AI and addressing systemic inequities, these findings have real-world implications for our protocols, training, and advocacy efforts. As EMS professionals, we have a responsibility to stay informed and apply these insights to our practice. For a deeper dive into these topics and more, I invite you to listen to the podcast, EMS Research with Professor Bram latest episode, https://youtu.be/rt_1AFzSLIk "Research Highlights and Innovations Shaping Our Field.”   References Alshehri, A., Panerai, R. B., Lam, M. Y., Llwyd, O., Robinson, T. G., & Minhas, J. S. (2025). Can we identify stroke sub-type without imaging? A multidimensional analysis. Medical Engineering & Physics. https://doi.org/10.1016/j.medengphy.2025.104364 Feerick, F., Coughlan, E., Knox, S., Murphy, A., Grady, I. O., & Deasy, C. (2025). Barriers to paramedic professionalisation: A qualitative enquiry across the UK, Canada, Australia, USA and the Republic of Ireland. BMC Health Services Research, 25(1), 993. https://doi.org/10.1186/s12913-025-10993-7 Gonzalez, J. M., Holland, L., Hernandez Torres, S. I., Arrington, J. G., Rodgers, T. M., & Snider, E. J. (2025). Enhancing trauma care: Machine learning-based photoplethysmography analysis for estimating blood volume during hemorrhage and resuscitation. Bioengineering, 12(8), 833. https://doi.org/10.3390/bioengineering12080833 Johnston, S., Waite, P., Laing, J., Rashid, L., Wilkins, A., Hooper, C., Hindhaugh, E., & Wild, J. (2025). Why do emergency medical service employees (not) seek organizational help for mental health support?: A systematic review. International Journal of Environmental Research and Public Health, 22(4), 629. https://doi.org/10.3390/ijerph22040629 Kamholz, J. C., Gage, C. B., van den Bergh, S. L., Logan, L. T., Powell, J. R., & Panchal, A. R. (2025). Association between organizational culture and emergency medical service clinician turnover. International Journal of Environmental Research and Public Health, 22(5), 756. https://doi.org/10.3390/ijerph22050756 Marsh, E., Orr, R., Canetti, E. F., & Schram, B. (2025). Profiling paramedic job tasks, injuries, and physical fitness: A scoping review. Applied Ergonomics, 125, 104459. https://doi.org/10.1016/j.apergo.2025.104459 McWilliam, S. E., Bach, J. P., Wilson, K. M., Bradford, J. M., Kempema, J., DuBose, J. J., ... & Brown, C. V. (2025). Should anything else be done besides prehospital CPR? The role of CPR and prehospital interventions after traumatic cardiac arrest. The Journal of Emergency Medicine. https://doi.org/10.1016/j.jemermed.2025.02.010 Mpody, C., Rudolph, M. I., Bastien, A., Karaye, I. M., Straker, T., Borngaesser, F., ... & Nafiu, O. O. (2025). Racial and ethnic disparities in use of helicopter transport after severe trauma in the US. JAMA Surgery, 160(3), 313–321. https://doi.org/10.1001/jamasurg.2024.5678 Shekhar, A. C., Kimbrell, J., Saharan, A., Stebel, J., Ashley, E., & Abbott, E. E. (2025). Use of a large language model (LLM) for ambulance dispatch and triage. The American Journal of Emergency Medicine, 89, 27–29. https://doi.org/10.1016/j.ajem.2025.05.004 Tagami, T., Takahashi, H., Suzuki, K., Kohri, M., Tabata, R., Hagiwara, S., ... & Ogawa, S. (2025). The impact of dispatcher-assisted CPR and prior bystander CPR training on neurologic outcomes in out-of-hospital cardiac arrest: A multicenter study. Resuscitation, 110617. https://doi.org/10.1016/j.resuscitation.2025.110617 Zhou, T., Wang, Y., Zhang, B., & Li, J. (2025). Racial and socioeconomic disparities in California ambulance patient offload times. JAMA Network Open, 8(5), e2510325. https://doi.org/10.1001/jamanetworkopen.2025.10325  

This conversation explores the life and legacy of Charles C. Diggs Jr., a significant yet often overlooked figure in the civil rights movement and American politics. Brown University Professor, Marion Orr, discusses his new biography of Diggs, detailing his contributions to the Congressional Black Caucus, his legislative achievements, and the circumstances surrounding his fall from grace. The discussion also touches on Diggs' personal life, his family's involvement, and the broader implications of his work for African American history and political science.Marion Orr is the inaugural Frederick Lippitt Professor of Public Policy and Professor of Political Science and Urban Studies at Brown University. He previously was a member of the political science faculty at Duke University.Professor Orr earned his B.A. degree in political science from Savannah State College, M.A. in political science from Atlanta University (now Clark-Atlanta University), and a Ph.D. in Government and Politics from the University of Maryland, College Park.From 2008-2014, Professor Orr served as Director of the A. Alfred Taubman Center for Public Policy and American Institutions at Brown University.  He is a former chair of Brown's Department of Political Science and a former director of Brown's Urban Studies Program.Professor Orr's expertise is in the area of American politics.  He specializes in urban politics, race and ethnic politics, and African-American politics.  He is the author and editor of eight books. His book, House of Diggs: The Rise and Fall of America's Most Consequential Black Congressman, Charles C. Diggs, Jr. (University of North Carolina Press, 2025), is the first biography of Michigan's first Black member of the U.S. House of Representatives.Among Professor Orr's other books, Black Social Capital: The Politics of School Reform in Baltimore (University Press of Kansas), won the Policy Studies Organization's Aaron Wildavsky Award and his co-authored, The Color of School Reform: Race, Politics and the Challenge of Urban Education (Princeton University Press), was named the best book by the American Political Science Association's (APSA) Urban Politics Section. He is the co-editor (with Domingo Morel) of Latino Mayors: Political Change in the Postindustrial City.  He is also the author of numerous scholarly articles, essays, and reviews.Professor Orr is the recipient of the Biographers International Organization Francis “Frank” Rollin Fellowship. He has also held a research fellowship at the Brookings Institution, a Presidential Fellowship from the University of California, Berkeley, and a fellowship from the Ford Foundation.  In 2019, Orr was awarded APSA's Hanes Walton, Jr. Career Award,  awarded to “a political scientist whose lifetime of distinguished scholarship has made significant contributions to our understanding of racial and ethnic politics and illuminates the conditions under which diversity and intergroup tolerance thrive in democratic societies.”Professor Orr served as President of the APSA's Organized Section on Urban Politics and an elected member and chair of the Governing Board of the Urban Affairs Association, an international organization devoted to the study of urban issues. Dr. Orr has also served as a member of the executive councils of the American Political Science Association and the National Conference of Black Political Scientists. He has served, or is currently serving, on the editorial boards of the National Political Science Review, Journal of Urban Affairs, Journal of Race, Ethnicity and the City, and Urban Affairs Review.

John Anderson speaks with James Orr to examine the deeper moral, cultural, and institutional pressures shaping Britain and the wider Western world. Drawing on political philosophy, social analysis, and recent events, Orr challenges the prevailing assumption that economic management and procedural politics can sustain a stable society. He argues that questions of identity, belonging, and shared obligation now sit at the centre of national renewal. This conversation traces the erosion of social trust, the limits of rights-based politics, and the consequences of demographic and cultural fragmentation. It is a measured discussion that reorients political debate toward the moral and cultural foundations required for long-term national stability, rather than short-term policy adjustments. Dr. Orr holds a PhD and MPhil in Philosophy of Religion from the University of Cambridge and a BA in Classics from Oxford. He is a political philosopher, writer, and commentator whose work focuses on conservatism, political theology, identity, and the cultural preconditions of liberal democracy, with particular attention to Britain's institutional and civilisational inheritance.

Buckeye Weekly Podcast: Breaking Down Ohio State vs Indiana in the Big Ten ChampionshipIn this episode of the Buckeye Weekly Podcast, hosts Tony Gerdeman and Tom Orr delve into Ohio State's 13-10 loss to Indiana in the 2025 Big Ten Championship Game. They discuss key plays and strategies, personnel decisions, and the performance of both teams. Topics include the red zone offense woes, linebacker responsibilities, defensive coverage challenges, and standout performances from players like Caden Curry and Sonny Styles. Gerdeman and Orr also reflect on how the game might impact future matchups and Ohio State's preparation for upcoming games. Tune in to get an in-depth look at what the Buckeyes can learn from this hard-fought game.00:00 Introduction and Welcome00:11 Revisiting the 2025 Big 10 Championship Game01:00 Ohio State's Red Zone Offense Analysis03:26 Key Plays and Player Performances04:44 Personnel Decisions and Game Strategy09:56 Caden Curry's Standout Game13:55 Defensive Backs and Wide Receivers Matchup19:52 High-Level Receivers for Indiana20:39 Linebackers' Unique Roles21:34 Arval Reese's Performance Analysis26:09 Ohio State's Touchdown Drive27:44 Missed Calls and Penalties32:28 Jeremiah Smith's Utilization33:58 Physicality and Strategy38:07 Concluding Thoughts and Next Steps

How Indiana Can Upset Ohio State: Buckeye Weekly Podcast PreviewIn this episode of the Buckeye Weekly Podcast, hosts Tony Gerdeman and Tom Orr delve into the upcoming Big Ten Championship game between Ohio State and Indiana. They break down how Indiana can potentially upset Ohio State, emphasizing keys to victory such as Indiana's strong mentality, quarterback Fernando Mendoza's resilience, the critical role of Indiana's defense, especially in the third down and red zone situations, and the significant emotional and home crowd advantage for Indiana. They also discuss Ohio State's red zone performance and the importance for the Buckeyes to avoid settling for field goals. Gerdeman and Orr examine Indiana's aggressive strategy, particularly in employing fourth-down plays, and highlight the potential psychological and motivational factors at play. Tune in for a comprehensive analysis of what could be a historic game for Indiana and the challenges that Ohio State will face.00:00 Introduction and Welcome00:10 Setting the Stage: Indiana vs. Ohio State00:44 Indiana's Key to Victory: Fernando Mendoza02:12 Indiana's Resilience in the Fourth Quarter04:19 Indiana's Defensive Strengths06:10 The Importance of Third Downs07:24 Aggressive Play Calling and Halftime Strategies12:17 Red Zone Defense: A Deciding Factor19:23 The Emotional and Historical Stakes23:28 Conclusion and Final Thoughts

Morse code transcription: vvv vvv Car sharing company ZipCar to end UK operations Trump releases fraudster executive days into prison sentence Teenage girl dies in minibus crash near Tadcaster Grammar School OBR chair Richard Hughes resigns over Budget day publishing error ORR reverses Avanti West Coasts Manchester London ghost train plan Zelensky says Ukraine territory most difficult issue, as US envoy prepares to meet Putin Police consider corporate manslaughter charges in Post Office scandal Doctors to stage five day strike before Christmas Luigi Mangione in court as lawyers seek to rule out notebook, gun and other key evidence Teen dies after getting out of ambulance on M5

Morse code transcription: vvv vvv Zelensky says Ukraine territory most difficult issue, as US envoy prepares to meet Putin OBR chair Richard Hughes resigns over Budget day publishing error Doctors to stage five day strike before Christmas Teen dies after getting out of ambulance on M5 ORR reverses Avanti West Coasts Manchester London ghost train plan Car sharing company ZipCar to end UK operations Trump releases fraudster executive days into prison sentence Teenage girl dies in minibus crash near Tadcaster Grammar School Police consider corporate manslaughter charges in Post Office scandal Luigi Mangione in court as lawyers seek to rule out notebook, gun and other key evidence

Morse code transcription: vvv vvv Car sharing company ZipCar to end UK operations Teen dies after getting out of ambulance on M5 ORR reverses Avanti West Coasts Manchester London ghost train plan Teenage girl dies in minibus crash near Tadcaster Grammar School OBR chair Richard Hughes resigns over Budget day publishing error Zelensky says Ukraine territory most difficult issue, as US envoy prepares to meet Putin Police consider corporate manslaughter charges in Post Office scandal Luigi Mangione in court as lawyers seek to rule out notebook, gun and other key evidence Doctors to stage five day strike before Christmas Trump releases fraudster executive days into prison sentence

durée : 00:57:54 - Le Book Club - par : Marie Richeux - L'écrivain Kevin Orr livre un roman intime qui oscille entre fantômes et lumières. A travers l'agonie d'un père, c'est toute une vie qui remonte : une mère fantasque disparue trop tôt, des secrets de famille et des violences tues, mais aussi, le souvenir d'un premier amour. - réalisation : Daphné Leblond - invités : Kevin Orr Ecrivain

At the height of the civil rights movement, Charles C. Diggs Jr. (1922–1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Dr. Marion Orr reveals that Diggs practiced a politics of strategic moderation. Dr. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson—two of Diggs's better-known Black contemporaries. Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Our guest is: Dr. Marion Orr, who is the inaugural Frederick Lippitt Professor of Public Policy and Professor of Political Science and Urban Studies at Brown University. He specializes in urban politics, race and ethnic politics, and African-American politics. Our host is: Dr. Christina Gessler, who produces the Academic Life podcast. She is a dissertation and grad student coach, and a developmental editor for humanities scholars at all stages of their careers. She writes the Academic Life Newsletter at ChristinaGessler.Substack.Com. Playlist for listeners: The End of White Politics The Vice-President's Black Wife No Common Ground The Social Constructions of Race Smithsonian American Women The First and Last King of Haiti Of Bears and Ballots Never Caught Welcome to Academic Life, the podcast for your academic journey—and beyond! Join us again to learn from more experts inside and outside the academy, and around the world. Missed any of the 275+ Academic Life episodes? Find them here. And get free bonus content HERE. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-american-studies

At the height of the civil rights movement, Charles C. Diggs Jr. (1922–1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Dr. Marion Orr reveals that Diggs practiced a politics of strategic moderation. Dr. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson—two of Diggs's better-known Black contemporaries. Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Our guest is: Dr. Marion Orr, who is the inaugural Frederick Lippitt Professor of Public Policy and Professor of Political Science and Urban Studies at Brown University. He specializes in urban politics, race and ethnic politics, and African-American politics. Our host is: Dr. Christina Gessler, who produces the Academic Life podcast. She is a dissertation and grad student coach, and a developmental editor for humanities scholars at all stages of their careers. She writes the Academic Life Newsletter at ChristinaGessler.Substack.Com. Playlist for listeners: The End of White Politics The Vice-President's Black Wife No Common Ground The Social Constructions of Race Smithsonian American Women The First and Last King of Haiti Of Bears and Ballots Never Caught Welcome to Academic Life, the podcast for your academic journey—and beyond! Join us again to learn from more experts inside and outside the academy, and around the world. Missed any of the 275+ Academic Life episodes? Find them here. And get free bonus content HERE. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

At the height of the civil rights movement, Charles C. Diggs Jr. (1922–1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Dr. Marion Orr reveals that Diggs practiced a politics of strategic moderation. Dr. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson—two of Diggs's better-known Black contemporaries. Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Our guest is: Dr. Marion Orr, who is the inaugural Frederick Lippitt Professor of Public Policy and Professor of Political Science and Urban Studies at Brown University. He specializes in urban politics, race and ethnic politics, and African-American politics. Our host is: Dr. Christina Gessler, who produces the Academic Life podcast. She is a dissertation and grad student coach, and a developmental editor for humanities scholars at all stages of their careers. She writes the Academic Life Newsletter at ChristinaGessler.Substack.Com. Playlist for listeners: The End of White Politics The Vice-President's Black Wife No Common Ground The Social Constructions of Race Smithsonian American Women The First and Last King of Haiti Of Bears and Ballots Never Caught Welcome to Academic Life, the podcast for your academic journey—and beyond! Join us again to learn from more experts inside and outside the academy, and around the world. Missed any of the 275+ Academic Life episodes? Find them here. And get free bonus content HERE. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

At the height of the civil rights movement, Charles C. Diggs Jr. (1922–1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Dr. Marion Orr reveals that Diggs practiced a politics of strategic moderation. Dr. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson—two of Diggs's better-known Black contemporaries. Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Our guest is: Dr. Marion Orr, who is the inaugural Frederick Lippitt Professor of Public Policy and Professor of Political Science and Urban Studies at Brown University. He specializes in urban politics, race and ethnic politics, and African-American politics. Our host is: Dr. Christina Gessler, who produces the Academic Life podcast. She is a dissertation and grad student coach, and a developmental editor for humanities scholars at all stages of their careers. She writes the Academic Life Newsletter at ChristinaGessler.Substack.Com. Playlist for listeners: The End of White Politics The Vice-President's Black Wife No Common Ground The Social Constructions of Race Smithsonian American Women The First and Last King of Haiti Of Bears and Ballots Never Caught Welcome to Academic Life, the podcast for your academic journey—and beyond! Join us again to learn from more experts inside and outside the academy, and around the world. Missed any of the 275+ Academic Life episodes? Find them here. And get free bonus content HERE. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/biography

In a time of deep political division and environmental crisis, what would it look like to design a democracy that's truly in harmony with the natural world?In this episode, we revisit a powerful 2022 conversation with David Orr, Professor of Practice at Arizona State University, editor of Democracy in a Hotter Time, and one of the leading voices at the intersection of ecology, education, and politics.Orr challenges us to think beyond short-term fixes and consider how a “biophilic democracy” rooted in care for each other and the planet could transform the way we live and govern. We explore why democracies fail, how our brains are wired for both division and connection, and how education might help us build a more resilient and compassionate society.Show Notes:Democracy in a Hotter Time: Climate Change and Democratic Transformation, edited by David W. OrrDemocracy Unchained: How To Rebuild Government For The People, edited by David W. Orr, Andrew Gumbel, Bakari Kitwana, and William S. BeckerDangerous Years: Climate Change, the Long Emergency, and the Way Forward by David OrrDemocracy in a Hotter Time, presentation at Elon University (YouTube)Design with Nature by Ian L. McHargThe Biophilia Hypothesis, edited by E.O. Wilson and Stephen R. KellertDr. David Orr and Dr. Miranda Yaver on the Stand Up! With Pete Dominick PodcastChildren & Nature NetworkLast Child in the Woods: Saving Our Children from Nature Deficit Disorder by Richard LouvDoughnut Economics: Seven Ways to Think Like a 21st Century Economist by Kate RaworthKeywords:  David Orr, biophilic democracy, nature and politics, ecological design, climate crisis, democracy reform, environmental education, sustainability, biophilia, civic engagement, ecological literacy, long-term thinking, political polarization, community resilience, democratic transformation, environmental ethics, nature connection, systems thinking, education and ecology, hope and renewal, doughnut economics, circular economyBiophilic Solutions is available wherever you get podcasts. Please listen, follow, and give us a five-star review. Follow us on Instagram and LinkedIn and learn more on our website. #NatureHasTheAnswers

Family, this week on Queer News Anna DeShawn continues to bring you the stories that matter most to our community. In top news, The Queer News Podcast has been nominated for four Black Podcast Awards! In politics, The Supreme Court is looking at 3 major cases that could impact the LGBTQIA+ community, and in Chicago Alderperson Jesse Fuentes was briefly handcuffed by ICE. In culture & entertainment, The inaugural BE gala rolled out the red carpet for LGBTQIA+ advocates and Khalid has released a new album that's queer and liberating af. Let's get into it. Want to support this podcast?

What does it mean to write the kind of poem that saves your life? In the first half of our two-part conversation on lyric poetry, we're joined by Gregory Orr to explore that urge to capture private emotion in a single, shining moment. We read and unpack Orr's poems and look to the past to tracing how feeling becomes a form in itself. Join us as we ask what lyric poetry can do in a noisy world—and why it keeps calling us back. Inevitably, Katie brings up haiku again!At the Table:Gregory OrrKatie DozierTimothy GreenDick WestheimerBrian O'SullivanJoe Barca

Buckeye Weekly Podcast: Breaking Down Michigan vs. Wisconsin and Looking Ahead to Ohio StateJoin Tony Gerdeman and Tom Orr in the latest episode of the Buckeye Weekly Podcast as they discuss Michigan's 24-10 victory over Wisconsin. The hosts express their frustrations with Wisconsin's football team and analyze Michigan's performance, focusing on the stand-out play of Donavon McCulley and Bryce Underwood. Additionally, they explore the potential implications of this game for Michigan's upcoming schedules and their significant matchups against USC and Ohio State. Gerdeman and Orr also touch on broader Big Ten developments and share their thoughts on the challenges ahead for both Michigan and USC. Don't miss this insightful episode where the hosts delve deep into the Michigan Wolverines' strategies, player performances, and prospects for the rest of the season.00:00 Introduction and Podcast Welcome00:10 Discussing Michigan and Wisconsin Games02:21 Michigan's Offensive Highlights13:21 Upcoming Michigan vs. USC Game14:56 Michigan's Defensive Performance28:48 Conclusion and Sign-Off

At the height of the civil rights movement, Charles C. Diggs Jr. (1922-1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Marion Orr reveals that Diggs practiced a politics of strategic moderation. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson--two of Diggs's better-known Black contemporaries.Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Marion Orr is the Frederick Lippitt Professor of Public Policy and professor of political science and urban studies at Brown University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-american-studies

At the height of the civil rights movement, Charles C. Diggs Jr. (1922-1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Marion Orr reveals that Diggs practiced a politics of strategic moderation. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson--two of Diggs's better-known Black contemporaries.Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Marion Orr is the Frederick Lippitt Professor of Public Policy and professor of political science and urban studies at Brown University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

At the height of the civil rights movement, Charles C. Diggs Jr. (1922-1998) was the consummate power broker. In a political career spanning 1951 to 1980, Diggs, Michigan's first Black member of Congress, was the only federal official to attend the trial of Emmett Till's killers, worked behind the scenes with Martin Luther King Jr., and founded the Congressional Black Caucus. He was also the chief architect of legislation that restored home rule to Washington, DC, and almost single-handedly ignited the American anti-apartheid movement in the 1960s. Drawing on extensive archival research, including Diggs's rarely seen personal papers, FBI documents, and original interviews with family members and political associates, political scientist Marion Orr reveals that Diggs practiced a politics of strategic moderation. Orr argues that this quiet approach was more effective than the militant race politics practiced by Adam Clayton Powell and more appealing than the conservative Chicago-style approach of William Dawson--two of Diggs's better-known Black contemporaries.Vividly written and deeply researched, House of Diggs is the first biography of Congressman Charles C. Diggs Jr., one of the most consequential Black federal legislators in US history. Congressman Diggs was a legislative lion whose unfortunate downfall punctuated his distinguished career and pushed him and his historic accomplishments out of sight. Now, for the first time, House of Diggs restores him to his much-deserved place in the history of American politics. Marion Orr is the Frederick Lippitt Professor of Public Policy and professor of political science and urban studies at Brown University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/history

In the latest blind tasting episode of GuildSomm: Into the Glass, host and Master Sommelier Chris Tanghe chats with Erica Orr, a Washington winemaker and enologist. Erica crafts the wines for her own label, Orr, and also has a lab service providing wine analysis and consulting for other Washington wineries. Chris pours her a white, a rosé, and a red. After Erica tastes the wines blind, she and Chris discuss winemaking cause and effect. Thanks for listening. If you enjoy this episode, please consider leaving us a review, as it helps us connect and grow the GuildSomm community. Cheers! Erica ran analysis on the wines that she and Chris tasted, which you can find on our website. Click over only when you're ready for the wines to be revealed! https://www.guildsomm.com/public_content/features/podcasts/b/guild_podcasts/posts/tasting-with-winemaker-erica-orr  Find out more about Erica's wine lab: https://www.orrwinelab.com Learn about Orr Wines: https://ericaorrwines.com Read our Tasting Study Guide: https://www.guildsomm.com/learn/study/w/study-wiki/2683/tasting Discover more GuildSomm blind tasting resources: https://www.guildsomm.com/learn/blind-tasting/

Branden Keith Orr is an alleged predator caught in a Polk County, Florida investigation of Takedown with Chris Hansen. Known for working as a lifeguard at Disney World and giving ghost tours, Orr became infamous for fleeing the sting house and being tased by deputies in the yard. As part of Operation Cyber Guardian, the Polk County Sheriff's Office set up a sting house and was “bombarded” with men attempting to meet minors for sex. Orr was one of them, engaging in an explicit chat with a decoy posing as a 14-year-old girl. He quickly escalated the conversation, suggesting they watch a movie, cuddle, make out, and have sex—promising to bring a condom. When the decoy asked if sex would hurt, he replied, “It's not going to hurt for me.” After a 45-minute drive, Orr parked, briefly left, then returned and approached the house—only to suddenly flee. Deputies chased him around the yard and tased him before arresting him. A condom was found in his back pocket. Once detained, he was brought back inside, where Chris interviewed him while officers searched him. Learn more about your ad choices. Visit megaphone.fm/adchoices

John Orr was a renowned fire investigator who was also a prolific arsonist, and whose thinly veiled novel helped to convict him. In this episode we hear from the fire captain who first suspected him—and from Orr himself. New episodes every Tuesday.To read more about these cases, visit Crimes of the Times at latimes.comVideo episodes will be available on Spotifyand Youtube.