Podcasts about cll

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Best podcasts about cll

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Latest podcast episodes about cll

PVRoundup Podcast
CLL at ASH 2025: BRUIN Studies and a Triplet for Richter Transformation

PVRoundup Podcast

Play Episode Listen Later Mar 2, 2026 15:39


Drs. Wierda and O'Brien discuss emerging data showing the non-covalent BTK inhibitor pirtobrutinib outperforming traditional chemoimmunotherapy and showing favorable efficacy and safety versus ibrutinib in CLL. They also highlight promising early results from a triplet regimen for Richter transformation, suggesting the best survival outcomes yet seen in this historically high‑risk, hard‑to-treat population.

Pharma and BioTech Daily
Regulatory Shifts and Scientific Breakthroughs Reshape Pharma

Pharma and BioTech Daily

Play Episode Listen Later Feb 23, 2026 6:25


Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into the dynamic landscape of these industries, exploring significant regulatory shifts, scientific breakthroughs, and strategic corporate maneuvers that are shaping the future of healthcare.The pharmaceutical and biotech sectors are currently navigating a period of profound transition. Recent regulatory developments have captured attention, particularly the U.S. Supreme Court's decision to overturn emergency tariffs imposed by the previous administration. This ruling is pivotal as it alleviates financial pressures on the industry, allowing companies to redirect their resources towards innovation and development. It underscores the interconnectedness of global supply chains and highlights the importance of stable regulatory environments for fostering industry growth.In a notable advancement within oncology, AstraZeneca has achieved FDA approval for its combination therapy of Calquence and Venclexta as an all-oral regimen for first-line chronic lymphocytic leukemia (CLL). This approval not only positions AstraZeneca competitively in the BTK inhibitor market but also signifies a shift towards more patient-friendly treatment regimens. By simplifying therapy, this development promises to enhance patient compliance and improve outcomes, challenging existing standards in CLL care.Meanwhile, internal challenges at the Centers for Disease Control and Prevention have led to a postponement of a critical vaccine advisory panel meeting. This delay occurs amid evolving vaccine policies that have sparked debate within the public health community, potentially impacting immunization strategies and initiatives aimed at bolstering public health.Corporate governance within the industry is also experiencing shifts. Novo Nordisk has nominated two industry veterans to its board as part of an ongoing strategy to align leadership with evolving business objectives. Similarly, Roche is contemplating divesting its once-blockbuster antibiotic Rocephin in response to competitive pressures from generics in Europe. These moves reflect a broader industry trend where companies are re-evaluating their portfolios to better respond to market dynamics and patent expirations.Novartis is making strategic changes as well by selling its stake in Novartis India Limited while maintaining separate commercial and R&D interests in the region. This action highlights a growing trend among pharmaceutical giants towards streamlining operations and focusing on high-growth areas—a strategy aimed at maximizing resource allocation efficiency.Despite narrowly missing a $1 billion revenue target for 2025, Madrigal Pharmaceuticals remains optimistic about the growth prospects of its drug Rezdiifra within the metabolic dysfunction-associated steatohepatitis (MASH) market. The company anticipates further expansion driven by unmet medical needs, underscoring the competitive dynamics within this therapeutic area.In personnel movements that could influence strategic directions, Daiichi Sankyo has appointed former Novartis CMO John Tsai as head of its R&D division. His expertise is expected to bolster Daiichi's focus on oncology and other critical therapeutic areas, potentially accelerating innovation within their drug development pipeline.Meanwhile, Manus Bio has secured a $15 million contract with the U.S. government for domestic supply of shikimic acid, an essential component for producing Tamiflu. This contract highlights efforts to strengthen domestic pharmaceutical supply chains amid global uncertainties—a crucial consideration for ensuring medication availability during crises.In clinical research, a setback was observed with Grail's Galleri cancer blood test trial failing to meet its primary endpoint in collaboration with the NHS. The resulting decline in GrailSupport the show

RNZ: Checkpoint
Government to fund two new blood cancer medicines

RNZ: Checkpoint

Play Episode Listen Later Feb 18, 2026 10:03


The Health Minister won't say if the government has met its promise to blood cancer patients in New Zealand - that is that they have not been forgotten. Pharmac has proposed to fund two new combination medicines to treat a type of blood cancer - chronic lymphocytic leukaemia or CLL. The drugs can help those with CLL achieve longer lasting remission and avoid the need for traditional chemotherapy. Patients and advocates are celebrating, but Blood Cancer NZ and the Ministers acknowledge more work needs to be done. Lillian Hanly reports.

Treating Blood Cancers
What's New and What's Next in CLL

Treating Blood Cancers

Play Episode Listen Later Feb 17, 2026 39:19


Brad Kahl, MD, Siteman Cancer Center, St. Louis MO Recorded on January 27, 2026 Brad Kahl, MD Professor of Medicine Division of Oncology, Department of Medicine Washington University School of Medicine Director, Lymphoma Program Siteman Cancer Center St. Louis, MO In this episode, join Dr. Brad Kahl, Director of the Lymphoma Program at the Siteman Cancer Center in St. Louis, Missouri, as he delivers a concise and practical overview of chronic lymphocytic leukemia (CLL), from initial disease presentation to key diagnostic considerations. Dr. Kahl discusses the prognostic value of cytogenetic testing and its impact on treatment selection and reviews currently approved therapeutic options alongside notable updates from the latest American Society of Hematology (ASH) meeting. He also examines emerging agents and ongoing clinical trials that are shaping the future CLL treatment landscape. The conversation further explores strategies for managing side effects, addressing complications, and supporting patients and caregivers. Tune in for this timely and informative discussion! Additional Blood Cancer United Resources: Blood Cancer United Accredited and Non-Accredited Healthcare Professional Education Blood Cancer United Resources for Patients

PVRoundup Podcast
Sequencing Targeted Therapies in the Management of Patients With CLL

PVRoundup Podcast

Play Episode Listen Later Feb 2, 2026 14:10


Drs. Coombs and Danilov explore how to optimally sequence covalent BTK inhibitors, non‑covalent BTK inhibitors (such as pirtobrutinib), and venetoclax-based regimens for relapsed CLL, emphasizing real-world data and emerging trial results. They highlight that treatment choices hinge on prior response depth and duration, tolerability, mutational profile, and the need to preserve future options and clinical trial eligibility.

OncLive® On Air
S15 Ep46: Expanded BTK Inhibitor Research Directs the Evolution of Pirtobrutinib Use in CLL: With Andrew Lipsky, MD

OncLive® On Air

Play Episode Listen Later Jan 31, 2026 20:14


In today's episode, Andrew Lipsky, MD, reviewed recent updates with BTK inhibitors in the chronic lymphocytic leukemia (CLL) treatment paradigm, including the clinical significance of the December 2025 FDA approval of pirtobrutinib (Jaypirca) in relapsed/refractory CLL and its effect on sequencing decisions for this disease. Dr Lipsky is an assistant professor of medicine at the Columbia University Medical Center in New York, New York.In the exclusive interview, Dr Lipsky expanded on the positioning of this agent within the evolving CLL treatment paradigm and patient characteristics that may inform its use in practice; key efficacy and safety findings from a pooled analysis of the phase 3 BRUIN CLL-321 (NCT04666038) and phase 1/2 BRUIN LOXO-BTK-18001 (NCT03740529) studies presented during the 2025 ASH Annual Meeting; and the evolving role of BTK inhibitors as a whole in CLL management.

The Options Insider Radio Network
The Option Block 1439: Skeletor is Lurking

The Options Insider Radio Network

Play Episode Listen Later Jan 26, 2026 56:53


Skeletor is lurking, the metals are screaming, and the earnings gauntlet has begun! In episode 1439 of The Option Block, Mark Longo and the All-Star panel—including "Uncle" Mike Tosaw and Andrew "The Rock Lobster" Giovinazzi—take a trip back to the 1980s. With the massive trailer launch for the new Masters of the Universe film, the team kicks things off with some MOTU trivia before breaking down a market that is getting "weird, wild, and funk-delicious." On the Docket: The Trading Block: A look at the "insane" run in Gold ($5k/oz!) and Silver ($100+/oz). Is it a meme, or is inflation finally catching up? Plus, a preview of the "Big Tech" earnings week featuring Meta, Apple, Microsoft, and Tesla. The Odd Block: Unusual activity in Papa John's (PZZA) puts, a massive upside play in Aero Copper Corp (ERO), and the "Trump Bump" fade in newcomer USA Rare Earth (USAR). The Strategy Block: Uncle Mike discusses the vital importance of choosing the right benchmarks (BXY, CLL, AGG) to measure your options performance accurately. Around the Block: The team debates whether the "Zero Day" index options will cannibalize the market and what to expect from the looming Apple and Tesla earnings prints. Key Market Levels & Tickers Mentioned: Indices: SPY, IWM, VIX (hovering at 16), VVIX (100) Equities: NVDA, TSLA, AAPL, INTC, MSFT, MAT, USAR Metals: GLD, SLV (up 12% in a single day)

The Option Block
The Option Block 1439: Skeletor is Lurking

The Option Block

Play Episode Listen Later Jan 26, 2026 56:53


Skeletor is lurking, the metals are screaming, and the earnings gauntlet has begun! In episode 1439 of The Option Block, Mark Longo and the All-Star panel—including "Uncle" Mike Tosaw and Andrew "The Rock Lobster" Giovinazzi—take a trip back to the 1980s. With the massive trailer launch for the new Masters of the Universe film, the team kicks things off with some MOTU trivia before breaking down a market that is getting "weird, wild, and funk-delicious." On the Docket: The Trading Block: A look at the "insane" run in Gold ($5k/oz!) and Silver ($100+/oz). Is it a meme, or is inflation finally catching up? Plus, a preview of the "Big Tech" earnings week featuring Meta, Apple, Microsoft, and Tesla. The Odd Block: Unusual activity in Papa John's (PZZA) puts, a massive upside play in Aero Copper Corp (ERO), and the "Trump Bump" fade in newcomer USA Rare Earth (USAR). The Strategy Block: Uncle Mike discusses the vital importance of choosing the right benchmarks (BXY, CLL, AGG) to measure your options performance accurately. Around the Block: The team debates whether the "Zero Day" index options will cannibalize the market and what to expect from the looming Apple and Tesla earnings prints. Key Market Levels & Tickers Mentioned: Indices: SPY, IWM, VIX (hovering at 16), VVIX (100) Equities: NVDA, TSLA, AAPL, INTC, MSFT, MAT, USAR Metals: GLD, SLV (up 12% in a single day)

Mike, Mike, and Oscar
Oscar Nom Predictions 2026 - We Guarantee at Least, Like, 5 of These Are Right - ORC 1/16/26

Mike, Mike, and Oscar

Play Episode Listen Later Jan 16, 2026 76:02


What Is This Episode - Top of Show . OSCAR NOM PREDICTIONS 2026: . Best Picture: Six Are Safe, Right? Seven? Eight? None? HELP! - 3:24 Director: A Guillermo Emergency - 14:08 Lead Actor: MBJ Better Be S-A-F-E - 18:44 Lead Actress: The Mikes Find the Same Five - 21:42 Supp Actress: In a World in Which Amy Madigan May Not Be Nominated - 24:52 Supp Actor: Mike1 Your Thoughts?! - 28:02 . Original Screenplay: Panahi DESERVES This - 29:46 Adapted Screenplay: A Guillermo Emergency, Part 2 - 33:33 Casting: Playing Tag in a Pitch Black Room - 35:14 Editing: How Many Best Picture Noms Do You Crossover? - 38:04 . Animated Feature: Where The Mikes Fight About Elio - 41:44 International Feature: Feels Like 6 Movies for 5 Slots - 44:46 Doc Feature: One Mike Says the Leading Doc is OUT - 46:58 Original Score/Song: How Many Train Dreams Appearances? Hamnet? - 50:05 . Cinematography: ASC, BSC, BCA, CLL, Alphabet Soup Precursory - 55:12 Production Design: What's Maleficent Have to do With This? - 58:14 Sound: How Much Can You Resist Sirat's Shortlist Game? - 1:00:12 MUAH: The Good Old Fashioned Lead Actress Crossover - 1:02:33 Costumes: Don't Overlook Ruth E! - 1:06:36 VFX: One Time for the One Timers - 1:08:19 . . What's Next From MMO/Leave Us 5 Stars! - 1:13:00

Dopey: On the Dark Comedy of Drug Addiction
Wednesday Dose of Erin “I Survived 2025 and all I got was this Lousy Cancer” A super emotional wednesday show.

Dopey: On the Dark Comedy of Drug Addiction

Play Episode Listen Later Jan 15, 2026 99:35


This week on the Wednesday Dose of Dopey! Dave kicks off an intensely emotional episode amid personal chaos—grieving Linda's dad's death, a bizarre Verizon outage conspiracy vibe, a $1,100 car repair scam, and a half-hearted gratitude meditation to stay grounded. He reads glowing listener comments on the recent Sid Vicious/Ned Van Zandt heroin epic, plugs stickers for Spotify/iTunes reviews, and shares a powerful email from Sarah E. about her ongoing brutal struggle with 7-OH (7-hydroxymitragynine) dependence after accidents and kratom escalation, highlighting deception, severe withdrawals, and the "master of deception" label despite a strong sober community.The core is a raw, heartfelt interview with returning guest Erin Khar (author of Strung Out, unlicensed advice columnist), who opens up about her recent diagnosis of small lymphocytic lymphoma (SLL) / chronic lymphocytic leukemia (CLL)—a slow-growing, incurable non-Hodgkin B-cell lymphoma discovered via routine mammogram/biopsy around Labor Day. Erin details the terrifying pathology call, symptoms (years of unexplained fatigue, anemia, frequent illnesses), watch-and-wait monitoring (no treatment yet until lymphocyte count rises), good-news/bad-news aspects (no chemo likely, keeps her hair, many live normal lifespans especially younger diagnoses like her at 52), and how curiosity over fear helps her cope.They explore parallels to addiction/recovery (one day at a time, sitting on hands during suicidal moments, grief + gratitude coexisting), family impact (kids' anxiety, protecting emotions), quality over quantity of life, and Erin's Substack reveal for connection. Ends with an Ask Erin advice segment, Johnny Thunders love ("Can't Put Your Arms Around a Memory"), and Trinity's cover of "Wanna Be Good So Bad". ALL THAT AND MORE MORE MORE! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Treating Blood Cancers
Key Insights from Attending ASH 2025

Treating Blood Cancers

Play Episode Listen Later Jan 13, 2026 33:51


Lore Gruenbaum, PhD, Blood Cancer United, Washington, DC Recorded on December 18, 2025 Lore Gruenbaum, PhD Chief Scientific Officer & Senior Vice President of Research Blood Cancer United Washington, DC Join Dr. Lore Gruenbaum, Chief Scientific Officer and Senior Vice President of Research at Blood Cancer United, to provide practice-changing data in hematologic malignancies from the 67th American Society of Hematology (ASH) Annual Meeting. Explored are breakthroughs in multiple myeloma, AML, CLL, and advances in cell therapy. Discussion also covers the growing use of artificial intelligence to accelerate precision medicine, spotlighting the Blood Cancer United Beat AML® Master Clinical Trial as a model for AI-driven trial design and real-time clinical decision-making. Tune in today for the key takeaways you need to know! Additional Blood Cancer United Resources: Blood Cancer United Accredited and Non-Accredited Healthcare Professional Education Blood Cancer United Resources for Patients

Oncology Brothers
ASH 2025 Lymphoma Highlights - EPCORE FL-1, CLL-17, BRUIN CLL-313, SWOG-1826: Dr. Julie Vose

Oncology Brothers

Play Episode Listen Later Jan 11, 2026 13:42


In this episode of the Oncology Brothers podcast, we were joined by Dr. Julie Vose, a leading expert in lymphoma from the University of Nebraska Medical Center. Together, we delved into the key abstracts presented at ASH 2025, focusing on significant studies in lymphoma and chronic lymphocytic leukemia (CLL). Episode Highlights: ● EPCORE FL-1: the approval of Epcoritamab in combination with Rituximab and lenalidomide for relapsed refractory follicular lymphoma ● CLL-17: comparison between continuous BTK inhibitors and fixed-duration venetoclax with obinutuzumab ● BRUIN CLL-313: insights into the non-covalent BTK inhibitor, pirtobrutinib, and its effectiveness in the frontline setting compared to traditional treatments ● S1826: a three-year update on the use of Nivolumab-AVD versus BV-AVD in advanced-stage Hodgkin's lymphoma, showcasing improved PFS and better tolerability Join us as we unpack these practice-changing studies and discuss their implications for community oncologists. Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Don't forget to subscribe for more insights and highlights from oncology conferences! #ASH25 #Oncology #Hematology #Lymphoma #CLL #CancerResearch

Research To Practice | Oncology Videos
Chronic Lymphocytic Leukemia — Proceedings from a Symposium Series Preceding the 67th ASH Annual Meeting and Exposition

Research To Practice | Oncology Videos

Play Episode Listen Later Jan 7, 2026 115:47


Featuring perspectives from Dr Matthew S Davids, Dr Bita Fakhri, Prof Constantine Tam and Dr Jennifer Woyach, including the following topics:  Introduction (0:00) Current and Emerging Approaches to First-Line Therapy for Chronic Lymphocytic Leukemia (CLL) — Dr Davids (1:42) Case: A man in his mid 70s with a plethora of comorbidities but good performance status requires treatment for CLL — Bhavana (Tina) Bhatnagar, DO (14:58) Case: A man in his early 50s, a Jehovah's Witness, under observation for IGHV-mutated CLL develops pulmonary emboli and worsening lymphadenopathy, undergoes anticoagulation and begins therapy with zanubrutinib — Jennifer Yannucci, MD Case: A man in his mid 70s with a history of atrial fibrillation on apixaban receives zanubrutinib — Zanetta S Lamar, MD (22:30) Optimal Management of Adverse Events with Bruton Tyrosine Kinase and Bcl-2 Inhibitors; Considerations for Special Patient Populations — Prof Tam (32:50) Case: A man in his mid 90s with CLL has concurrent locally advanced Merkel cell carcinoma of the scalp — Erik Rupard, MD (50:51) Case: A woman in her early 50s under observation for IGHV-unmutated CLL develops progressive splenomegaly and receives obinutuzumab/venetoclax — Sean Warsch, MD (54:28) Selection and Sequencing of Therapy for Relapsed/Refractory CLL — Dr Woyach (1:05:51) Case: A man in his mid 70s with high-risk (del[TP53]) CLL experiences disease progression on ibrutinib and then venetoclax/obinutuzumab — Dr Bhatnagar (1:27:23) Case: A man in his early 80s with IGHV-unmutated CLL who previously received FCR now experiences disease relapse after 5 years of acalabrutinib, and a BTK C481S resistance mutation is detected — Priya Rudolph, MD, PhD (1:29:34) Chimeric Antigen Receptor T-Cell Therapy and Other Novel Strategies for CLL — Dr Fakhri (1:34:08) Case: A man in his early 70s with multiregimen-relapsed CLL experiences an 18-month response to pirtobrutinib — Brian P Mulherin, MD (1:50:46) CME information and select publications

OncLive® On Air
S14 Ep72: CLL Treatment Paradigm Shifts With Evolving Treatment Sequencing and BTK Inhibition: With Joanna M. Rhodes, MD, MSCE; and Krish Patel, MD

OncLive® On Air

Play Episode Listen Later Dec 31, 2025 21:51


In today's episode, the discussion features Joanna M. Rhodes, MD, MSCE, director of Lymphoma and systems head for Lymphoma at Rutgers Cancer Institute of New Jersey and RWJBarnabas Health, alongside Krish Patel, MD, director of Lymphoma Research and executive chair of the Lymphoma Research Executive Committee at the Sarah Cannon Research Institute. Together, they discussed how the chronic lymphocytic leukemia (CLL) treatment paradigm continues to evolve with advances in targeted therapy. In this exclusive interview, Drs Rhodes and Patel highlighted key disease- and patient-related factors that guide first-line treatment selection, considerations that influence sequencing decisions in later lines of therapy, and how hematologists determine the optimal timing to transition between treatments. They also discussed the clinical distinctions between covalent and noncovalent BTK inhibitors, the current role of pirtobrutinib (Jaypirca) in CLL management, and how its safety profile and emerging data may inform future use earlier in the treatment course. The conversation concluded with reflections on the CLL data presented at the 2025 ASH Annual Meeting that were most relevant to clinical practice. nd many of your other favorite podcast platforms,* so you get a notification every time a new episode is posted. While you are there, please take a moment to rate us!

G.I.O. Get It On
LoveLine 12.22.2005

G.I.O. Get It On

Play Episode Listen Later Dec 23, 2025 92:54


LLAD – 12/22/2005 (feat. David Alan Grier) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.21.2005

G.I.O. Get It On

Play Episode Listen Later Dec 22, 2025 92:46


LLAD – 12/21/2005 (feat. David Alan Grier) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.20.2005

G.I.O. Get It On

Play Episode Listen Later Dec 21, 2025 94:00


LLAD – 12/20/2005 (feat. David Alan Grier and Chelsea Handler) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.19.2005

G.I.O. Get It On

Play Episode Listen Later Dec 20, 2025 92:51


LLAD – 12/19/2005 (feat. David Alan Grier) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.18.2005

G.I.O. Get It On

Play Episode Listen Later Dec 19, 2025 92:21


LLAD – 12/18/2005 (feat. David Alan Grier) Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

OncLive® On Air
S14 Ep65: ASH 2025 LBA BRUIN-CLL 313 Update: Pirtobrutinib vs Bendamustine/Rituximab in 1L CLL

OncLive® On Air

Play Episode Listen Later Dec 17, 2025 11:00


Two Onc Docs, hosted by Samantha A. Armstrong, MD, and Karine Tawagi, MD, is a podcast dedicated to providing current and future oncologists and hematologists with the knowledge they need to ace their boards and deliver quality patient care. Dr Armstrong is a hematologist/oncologist and assistant professor of clinical medicine at Indiana University Health in Indianapolis. Dr Tawagi is a hematologist/oncologist and assistant professor of clinical medicine at the University of Illinois in Chicago. In this episode, OncLive On Air® partnered with Two Onc Docs to highlight chronic lymphocytic leukemia (CLL) updates from the 2025 ASH Annual Meeting. Drs Armstrong and Tawagi noted that CLL is typically diagnosed in asymptomatic, elderly individuals presenting with lymphocytosis. A definitive diagnosis is established by confirming the clonality of circulating B lymphocytes via immunoglobulin light chain restriction on flow cytometry, they explained. Treatment initiation is reserved for active disease, which is indicated by B symptoms, progressive cytopenias, threatened organ function, or bulky disease such as splenomegaly, they said. They continued by reporting several prognostic features that denote poor outcomes. Current standard frontline regimens use covalent BTK inhibitors or time-limited targeted regimens that include venetoclax (Venclexta), often combined with an anti-CD20 monoclonal antibody, according to the experts. They added that TKI-based therapy is preferred for patients with high-risk features. The phase 3 BRUIN CLL-313 trial (NCT05023980) investigated pirtobrutinib (Jaypirca), a highly selective noncovalent BTK inhibitor, compared with bendamustine and rituximab (BR) in patients with treatment-naive CLL. The trial showed a significant improvement in progression-free survival with pirtobrutinib vs BR. Pirtobrutinib was also associated with a favorable safety profile, with modest rates of class-associated toxicities, including all-grade bleeding, arthralgia, and atrial fibrillation. Although pirtobrutinib showed superior efficacy in BRUIN CLL-313, the clinical interpretation of these data is complicated because BR is an outdated control arm compared with contemporary frontline standards, Armstrong and Tawagi emphasized. Furthermore, the requirement for indefinite therapy with BTK inhibitors is a sequencing challenge, particularly as pirtobrutinib is currently approved in the post-covalent BTK inhibitor setting, they continued. However, its favorable toxicity profile suggests potential utility in elderly patients with pre-existing cardiovascular comorbidities, they noted. Future studies are focused on comparing pirtobrutinib vs time-limited venetoclax and evaluating various triplet regimens, they concluded.

G.I.O. Get It On
LoveLine 12.15.2005

G.I.O. Get It On

Play Episode Listen Later Dec 16, 2025 94:02


LLAD – 12/15/2005 (feat. Cypress Hill) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.14.2005

G.I.O. Get It On

Play Episode Listen Later Dec 15, 2025 92:30


LLAD – 12/14/2005 (feat. Jack Osbourne) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.13.2005

G.I.O. Get It On

Play Episode Listen Later Dec 14, 2025 91:20


LLAD – 12/13/2005 (feat. Korn) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.12.2005

G.I.O. Get It On

Play Episode Listen Later Dec 13, 2025 92:49


LLAD – 11/28/2005 (feat. Ben Stein – Full episode replay) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

Research To Practice | Oncology Videos
Chronic Lymphocytic Leukemia — Proceedings from a Symposium Held in Partnership with the American Oncology Network

Research To Practice | Oncology Videos

Play Episode Listen Later Dec 12, 2025 51:19


Featuring perspectives from Dr Kerry Rogers, moderated by Dr Stephen "Fred" Divers, including the following topics:  Chronic Lymphocytic Leukemia (CLL) — Dr Rogers (0:00) Case: A man in his mid 70s with CLL and a history of atrial fibrillation — Dr Lamar (13:08) Case: A fit man in his early 80s with IGHV-unmutated, TP53-mutant symptomatic CLL — Dr Mulherin (21:16) Case: A woman in her mid 80s with IGHV-mutated recurrent CLL who receives pirtobrutinib — Dr Warsch (32:41) Case: A woman in her late 70s with recurrent del(17p) CLL who receives venetoclax/obinutuzumab — Dr Yannucci (44:52) CE information and select publications

G.I.O. Get It On
LoveLine 12.08.2005

G.I.O. Get It On

Play Episode Listen Later Dec 9, 2025 91:22


LLAD – 12/08/2005 (feat. AFI) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.07.2005

G.I.O. Get It On

Play Episode Listen Later Dec 8, 2025 92:17


LLAD – 12/07/2005 (feat. Mike Shinoda) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.06.2005

G.I.O. Get It On

Play Episode Listen Later Dec 7, 2025 92:39


LLAD – 12/06/2005 (feat. Jason Mewes) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.05.2005

G.I.O. Get It On

Play Episode Listen Later Dec 6, 2025 92:34


LLAD – 12/05/2005 (feat. Steve-O) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.04.2005

G.I.O. Get It On

Play Episode Listen Later Dec 5, 2025 92:41


LLAD – 12/04/2005 (feat. Steve-O) Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 12.01.2005

G.I.O. Get It On

Play Episode Listen Later Dec 2, 2025 92:05


LLAD – 12/01/2005 (feat. James Van Praagh) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.30.2005

G.I.O. Get It On

Play Episode Listen Later Dec 1, 2025 92:16


LLAD – 11/30/2005 (feat. Andy Milonakis) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.29.2005

G.I.O. Get It On

Play Episode Listen Later Nov 30, 2025 92:30


LLAD – 11/29/2005 (feat. Andy Milonakis) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.28.2005

G.I.O. Get It On

Play Episode Listen Later Nov 29, 2025 92:49


LLAD – 11/28/2005 (feat. Ben Stein) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.27.2005

G.I.O. Get It On

Play Episode Listen Later Nov 28, 2025 92:06


LLAD – 11/27/2005 (feat. Patton Oswalt) Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.23.2005

G.I.O. Get It On

Play Episode Listen Later Nov 24, 2025 91:44


LLAD – 11/23/2005 (feat. The Love Between The Two Hosts) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.22.2005

G.I.O. Get It On

Play Episode Listen Later Nov 23, 2025 91:47


LLAD – 11/22/2005 (feat. Tom Arnold) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.21.2005

G.I.O. Get It On

Play Episode Listen Later Nov 22, 2025 91:59


LLAD – 11/21/2005 (feat. Andy Dick) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.20.2005

G.I.O. Get It On

Play Episode Listen Later Nov 21, 2025 93:56


LLAD – 11/20/2005 (feat. The All American Rejects) Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.17.2005

G.I.O. Get It On

Play Episode Listen Later Nov 18, 2025 92:40


LLAD – 11/17/2005 (feat. Rob Schneider) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.16.2005

G.I.O. Get It On

Play Episode Listen Later Nov 17, 2025 92:40


LLAD – 11/16/2005 (feat. Rob Schneider) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.15.2005

G.I.O. Get It On

Play Episode Listen Later Nov 16, 2025 92:38


LLAD – 11/15/2005 (feat. Rob Schneider) Tuesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.14.2005

G.I.O. Get It On

Play Episode Listen Later Nov 15, 2025 92:14


LLAD – 11/14/2005 (feat. Rob Schneider) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.13.2005

G.I.O. Get It On

Play Episode Listen Later Nov 14, 2025 92:51


LLAD – 11/13/2005 (feat. Rob Schneider) Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.10.2005

G.I.O. Get It On

Play Episode Listen Later Nov 11, 2025 90:55


LLAD – 11/10/2005 (feat. Xzibit) Thursday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.09.2005

G.I.O. Get It On

Play Episode Listen Later Nov 10, 2025 92:31


LLAD – 11/09/2005 (feat. Danny Bonaduce and Gretchen Bonaduce) Wednesday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.08.2005

G.I.O. Get It On

Play Episode Listen Later Nov 9, 2025 92:26


LLAD – 11/08/2005 (feat. Danny Bonaduce) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.07.2005

G.I.O. Get It On

Play Episode Listen Later Nov 8, 2025 90:36


LLAD – 11/07/2005 (feat. D. L. Hughley) Monday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
LoveLine 11.06.2005

G.I.O. Get It On

Play Episode Listen Later Nov 7, 2025 91:56


LLAD – 11/06/2005 (feat. Benji Madden) 11/06/2005 – Sunday Night Show Source – Fan Stream Recording (2005) This episode is 100% complete with a minor audio upgrade. The first episode of the LoveLine A.D. era, Dr. Drew, Anderson and a revolving guest host. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and perhaps commission him for your next project. Venmo

G.I.O. Get It On
GLL Episode 2635

G.I.O. Get It On

Play Episode Listen Later Nov 4, 2025 109:47


CLL #2635 (feat. The Love Between The Two Hosts) 11/03/2005 – Thursday Night Show Source – Tucker Stream Recording (2005) This episode is 100% complete with a medium audio upgrade. Adam’s final episode, complete with cameo phoners and lots of poignant moments, however there is a moment of “free speech absolutism” with a racial slur not often heard on the show at roughly the halfway mark, just a heads up. The Love Between The Two Hosts – CLL on Youtube, with Video for select episodes. https://adamanddrdrewshow.com/1743-loveline-nostalgia-with-superfan-giovanni/ https://account.venmo.com/u/GiovanniGiorgio Paid Link – As an Amazon Associate I earn from qualifying purchases. Music Provided by Rich Banks Check out His Website and Soundcloud to hear more of his awesome work and Read More →