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From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and Kathy about his career and the scientific difficulties he and his laboratory encountered in their attempts to achieve replication of hepatitis C virus in cells in culture. Hosts: Vincent Racaniello and Kathy Spindler Guest: Charlie Rice Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV 2020 Nobel Prize (Nobel Prizes) Hepatitis C human challenge study (Lancet Gastro Hepatol) Rat hepacivirus mouse model for hepatitis C (Hepatol) Replication of hepatitis C virus in cells in culture (Science) Lessons from domestication of HCV (Curr Opin Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
“Early impacts of cover crop selection on soil biological parameters during a transition to organic agriculture” with Nick Boodages. Incorporating cover crops is an important step in the transition from conventional to organic growing practices, but in Texas, limited resources can bring complications. In this episode, Nick joins me to discuss his work researching how to help farmers make the leap. Tune in to learn: · What challenges Texan farmers face when hoping to transition to organic agriculture · Which cover crops perform best in the Texas high plains · Which challenges Texan farmers face when growing cover crops · How cover crops impact crop yields during the transition to organic If you would like more information about this topic, this episode's paper is available here: https://doi.org/10.1002/agg2.20532 This paper is always freely available. Contact us at podcast@sciencesocieties.org or on Twitter @FieldLabEarth if you have comments, questions, or suggestions for show topics, and if you want more content like this don't forget to subscribe. If you'd like to see old episodes or sign up for our newsletter, you can do so here: https://fieldlabearth.libsyn.com/. If you would like to reach out to Nick, you can find him here: nicholas.boogades@ag.tamu.edu Resources CEU Quiz: Coming soon Transcripts: https://www.rev.com/app/transcript/Njg2ZTdhM2M3MTljMjMzZjYxOWE2ODlidXpYcmF2ZDF0Z04x/o/VEMwNzYxNzAyNjY3 Texas A&M AgriLife extension: https://agrilifeextension.tamu.edu/ Lewis and Burke Labs: www.txsoillab.com Organic Transition-Cotton Peanut Rotation extension paper: https://agriliferollingplainsagronomy.org/2022/11/22/organic-transition-cotton-peanut-rotation/ Alternative Certifications for Organic Transition: Quality Assurance Initiative (QAI)-Certified Organic Transition: https://www.qai-inc.com/certification-services/transitional.php/ Non GMO project: https://www.nongmoproject.org/ Certified naturally grown: https://www.naturallygrown.org/ Grazing Cover Crops in the Great Plains with Drs. John Holman and Augustine Obour: https://fieldlabearth.libsyn.com/grazing-cover-crops-in-the-great-plains-with-drs-john-holman-and-augustine-obour Thank you to our volunteer Om Prakash Ghimire for help with the shownotes and other assets. Thank you to Cole Shalk from 12twelve Media for the Audio Processing on today's episode. Field, Lab, Earth is Copyrighted by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.
What if your skincare routine started in your gut? Danielle Duboise and Whitney Tingle are joined by integrative gastroenterologist and microbiome expert Dr. Robynne Chutkan for a deep dive into the powerful connection between the gut and the skin. Dr. Chutkan unpacks how your gut health directly impacts the appearance, texture, and vitality of your skin—especially during hormonal shifts in your 40s and 50s. Plus, Dr. Chutkan shares her science-backed, food-first protocols for creating a glowing complexion from the inside out. Check out the video version on the Sakara Life YouTube channel here: https://youtu.be/HMGRo28Z6zs Dr. Chutkan shares: The gut-skin axis explained: how it works and why it matters What skin symptoms can tell you about your internal health How hormone changes during perimenopause impact the microbiome and the skin Dr. Chutkan's approach to healing skin through gut-supportive foods The truth about stool tests, food sensitivity panels, and skincare fads About Dr. Chutkan: Robynne Chutkan, MD, FASGE, is a gastroenterologist, the author of the digestive health books Gutbliss, The Microbiome Solution, The Bloat Cure and The Anti-Viral Gut, and the host of The Gutbliss podcast. Dr. Chutkan received her bachelor's from Yale University and her medical degree from Columbia College of Physicians and Surgeons, where she also did her internship and residency and served as chief resident. She completed her fellowship in gastroenterology at Mount Sinai Hospital in New York. Dr. Chutkan has been on the faculty at Georgetown University Hospital since 1997. In 2004 she founded the Digestive Center for Wellness, an integrative gastroenterology practice dedicated to uncovering the root cause of GI disorders. Dr. Chutkan incorporates microbial optimization, nutritional therapy, mind-body techniques, and lifestyle changes into her therapeutic approach to digestive disorders. A former Board member of the American Society for Gastrointestinal Endoscopy (ASGE), Dr. Chutkan also chaired the ASGE Training Committee and Public Relations Committee. She has authored dozens of academic journal articles and book chapters and lectures frequently on the microbiome and gut health throughout the United States and Europe. Dr. Chutkan has been the medical expert on The Today Show, CBS This Morning, The Doctors, The Dr Oz Show, The Megyn Kelly Show, and has her own PBS Special entitled “Gutbliss”. She's been interviewed by numerous publications, including the NYT, WSJ, The Atlantic, and the Washington Post, and served as on-air talent and a medical consultant for Discovery Health Channel. Resources & Links: Dr. Robynne Chutkan: gutbliss.com | @gutbliss Books by Dr. Chutkan: Gutbliss, The Microbiome Solution, The Bloat Cure, The Anti-Viral Gut The Gutbliss Podcast
Hoy en Me lo Dijo Adela hablamos del riesgo de una contrarreforma electoral, del pleito con Estados Unidos, del juicio de Ovidio Guzmán… y del estreno de una película mexicana con sabor a caos. Platicamos con Ricardo Becerra, presidente del Instituto de Estudios para la Transición Democrática, sobre la carta que le enviaron a Claudia Sheinbaum para pedirle que su Reforma Electoral no destruya la pluralidad. ¿Escuchará o se impondrá el mayoriteo? También conversamos con Larry Rubin, presidente de la American Society of México, sobre las nuevas tensiones con Estados Unidos: incumplimientos del T-MEC, amagos de aranceles y creciente desconfianza empresarial. ¿Habrá renegociación? En nuestra mesa editorial con Damián Zepeda, Arturo Ávila y Juan Zavala. Y cerramos con cine mexicano: nos visitan Manuel García Rulfo y Darío Yazbek Bernal, protagonistas de Buen Salvaje, una película que desnuda el colapso emocional de una pareja americana en un pueblo de México. Caos, culpa y redención.
In this episode of Diverse, Ana Tijerina Esquino, civil engineer at Mott MacDonald, explains why engineering is fundamentally a helping profession that aims to improve society. Ana discusses her unconventional journey into civil engineering, how infrastructure projects have historically harmed marginalized communities, and sustainable practices that are changing the industry in conversation with Laurie Shuster, editor-in-chief of SWE Magazine. Hear Ana's reflections on the funding of ports and mass transit, as well as the American Society of Civil Engineers' 2025 Report Card for America's Infrastructure, in the Spring 2025 issue of SWE Magazine. --- The Society of Women Engineers is a powerful, global force uniting 50,000 members of all genders spanning 85 countries. We are the world's largest advocate and catalyst for change for women in engineering and technology. To join and access all the exclusive benefits to elevate your professional journey, visit membership.swe.org
Hoy en Me lo Dijo Adela hablamos del riesgo de una contrarreforma electoral, del pleito con Estados Unidos, del juicio de Ovidio Guzmán… y del estreno de una película mexicana con sabor a caos. Platicamos con Ricardo Becerra, presidente del Instituto de Estudios para la Transición Democrática, sobre la carta que le enviaron a Claudia Sheinbaum para pedirle que su Reforma Electoral no destruya la pluralidad. ¿Escuchará o se impondrá el mayoriteo? También conversamos con Larry Rubin, presidente de la American Society of México, sobre las nuevas tensiones con Estados Unidos: incumplimientos del T-MEC, amagos de aranceles y creciente desconfianza empresarial. ¿Habrá renegociación? En nuestra mesa editorial con Damián Zepeda, Arturo Ávila y Juan Zavala. Y cerramos con cine mexicano: nos visitan Manuel García Rulfo y Darío Yazbek Bernal, protagonistas de Buen Salvaje, una película que desnuda el colapso emocional de una pareja americana en un pueblo de México. Caos, culpa y redención.
Secondo un nuovo studio americano presentato al congresso scientifico annuale dell’American Society for Metabolic and Bariatric Surgery (segery), la chirurgia bariatrica, oltre a ridurre i rischi metabolici, porta a un significativo aumento dell’autostima nel primo anno dopo l’intervento. A Obiettivo Salute il commento del dottor Alessandro Giovanelli, responsabile INCO, Istituto Nazionale per la Cura dell’obesità, presso l’IRCCS Ospedale Galeazzi-Sant’Ambrogio di Milano.
Did you know that stopping GLP-1 medications like Ozempic or Wegovy can trigger powerful biological and emotional changes that impact your weight journey? In this episode, I talk about what happens when you stop taking a GLP-1 medication, like Ozempic, Wegovy, or Zepbound. I explain how these medications work by slowing stomach emptying, reducing appetite, and helping with insulin regulation, which supports weight loss and benefits conditions like type 2 diabetes and PCOS. However, I also share that they're not magic pills, you still need healthy habits like eating well and exercising. I highlight possible side effects, such as nausea or pancreatitis risks, and emphasize that stopping these medications can lead to increased hunger, cravings, weight regain, and even emotional distress. But I also reassure you that this isn't a sign of failure. Weight regain is often biological, not personal. I offer tips for tapering off safely, reinforcing lifestyle habits, and exploring other options. Most importantly, I remind you that your journey is valid, you're not alone, and lasting success requires a plan, support, and self-compassion. Tune in to learn what really happens when you stop taking GLP-1 medications—and how to stay empowered and in control of your weight journey. Episode Highlights: How GLP-1 medications like Ozempic and Wegovy work Common side effects and safety considerations What to expect when stopping GLP-1s, both physically and emotionally Strategies to manage weight regain and maintain healthy habits Alternative tools and support options beyond medication Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
On this episode, we are joined by Mike Mueller, an occupational therapist, Certified Hand Therapist and exercise scientist who has taken a special interest in treating female athletes across the lifespan. We discuss unique characteristics of female athletes, common injuries we are seeing in this population and how we as upper extremity specialists can help to return these athletes to their sport. Guest Bio: Mike Mueller, OTR, CHT is a staff hand therapist at Rothman Orthopaedics in Philadelphia, Pennsylvania and has over 30 years of experience in upper extremity rehabilitation in a variety of settings. He is an occupational therapist, Certified Hand Therapist and an exercise scientist with extensive experience utilizing the kinetic chain approach and its application to upper extremity rehabilitation and performance. He has a special area of interest in the management of the athlete's upper extremity injuries and has extensive experience with athletes from the youth to the professional levels. Mike has presented on multiple topics at state, national and international conferences. He is a member of The American Society of Hand Therapists, American Occupational Therapy Association, American College of Sports Medicine, National Strength and Conditioning Association, and American Baseball Biomechanics Society.The views and opinions expressed in the Hands in Motion podcast are those of the guests and do not necessarily reflect the official policy or position of ASHT. Appearance on the podcast does not imply endorsement of any products, services or viewpoints discussed"
From a “game-changer” in triple-negative disease to broader paradigm shifts and practice changes, the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting was pivotal for breast cancer care, says Sara M. Tolaney, MD, MPH, chief of the Division of Breast Medical Oncology at the Dana-Farber Cancer Institute in Boston, Massachusetts. Dr. Tolaney broke down some of the top data at ASCO 2025 with Robert A. Figlin, MD, the interim director of Cedars-Sinai Cancer in Los Angeles, California, and Steven Spielberg Family Chair in Hematology-Oncology. She singled out findings from the ASCENT-04 trial, the plenary session on SERENA-6, and the DESTINY-Breast09 trial. “I think it's been a very exciting ASCO for breast cancer overall, with just so much exciting data,” Dr. Tolaney concluded.
In this episode, Jonathan Sackier welcomes Claudio Cerchione, haematologist and researcher at the Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. From his early interest in plasma cell disorders, Cerchione shares key insights into the evolution of multiple myeloma (MM) research, the rising role of minimal residual disease (MRD), and promising developments in monoclonal antibodies and CAR-T therapy. He also reflects on standout moments from recent European Hematology Association (EHA) Congress and American Society of Clinical Oncology (ASCO) Annual Meeting, and shares his hopes for the future of haematology. Timestamps: 2:14: Memorable career experiences for Claudio 4:20 Biggest breakthrough in MM 5:10 Interest in plasma cell disorders 6:30 A surprising fact about multiple myeloma 7:40 Claudio's top choice for a dinner party guest 10:30 The importance of MRD in haematology 13:00 Monoclonal antibodies and CAR-T therapies 19:00 Current challenges 22:22 Claudio's key EHA and ASCO takeaways 28:30 Claudio's three magic wishes
Results from the phase 3 ATOMIC trial are practice changing for colorectal cancer care and raise broader questions about immunotherapy use in patients with mismatch repair deficiencies across tumor types. Frank A. Sinicrope, MD, a professor of oncology and medicine at the Mayo Clinic Comprehensive Cancer Center in Rochester, Minnesota, presented the findings at the 2025 American Society of Clinical Oncology Annual Meeting. He discussed the significance of the ATOMIC results and next steps with Robert A. Figlin, MD, the interim director of Cedars-Sinai Cancer in Los Angeles and Steven Spielberg Family Chair in Hematology-Oncology. “I think that microsatellite instability is a terrific predictive biomarker for immunotherapy, and all of these patients should get immunotherapy in some form or another,” Dr. Sinicrope noted.
Send us a textIn this episode, Dr. Eeks sits down with world-renowned cardiologist and nutrition dynamo Dr. Kim Williams to pull the lid off “healthy” plant-based restaurant meals, and a whole lot more.What's on the menu:First-of-its-kind restaurant study – How Dr. Williams scored plant-based dishes for heart health, what shocked him, and the sneaky “health halo” traps you'll now spot a mile away.Plant-based vs. junk-based – Could plant-based be sliding toward the same fate as the Western diet? He breaks down where things are headed and how to dodge the pitfalls.Cardio-nutrition deep dive – The eating plan Dr. Williams follows himself, plus straight talk on saturated fat, carbs, sugar, cholesterol, animal welfare, and factory farming.Big-picture fixes – Population-level policies he believes could actually move the needle on improving nutrition at the public health level.If you eat out, care about your heart, or just want the unvarnished science behind plant-powered plates, this episode is packed with gems you won't want to miss.Dr. Kim Allan Williams, MD, MACC, FAHA, MASNC, FESC is Chair of Medicine at the University of Louisville and a triple-threat in general, preventive, and cardiovascular-imaging cardiology. He's a former President of both the American College of Cardiology and the American Society of Nuclear Cardiology, and he previously led the Association of Black Cardiologists as Board Chair. At Wayne State he launched the Urban Cardiology Initiative, and later created Rush University's H.E.A.R.T. Program (Helping Everyone Assess Risk Today)—community screenings that pair education, nutrition, and lifestyle coaching. A lifelong advocate for nutrition literacy, health-equity, and system-wide reform, Dr. Williams has advised the FDA, CMS, and served more than 25 years as an AMA delegate. Most recently, he sat on the 2022 task force that briefed the White House Conference on Nutrition, Health, and Hunger.You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here! (Now featuring interviews with top experts on health you care about!)Support the show
Send us a message!In this episode Dana interviews Award winning food and travel journalist, speaker, author, nutrition communications consultant, television personality and registered dietitian nutritionist, Carolyn O'Neil, MS, RDN.Carolyn shares how she found her love of nutrition (and writing) and started working in nutrition media. Carolyn's newly launched podcast is Watch What You Eat with Carolyn O'Neil. Find her on Instagram at @carolynoneil More about our guest:Carolyn writes about food, nutrition, travel and healthy lifestyles for numerous publications including VIE Magazine, OLTRE Magazine, Atlanta Homes & Lifestyles Magazine, Southern Living Magazine and Food & Wine Magazines. She is on the Nutrition Review Board for Southern Living Magazine and Forbes Health.Carolyn is a member of the invite-only Google Food Lab, an international group of thought leaders in all areas of food from farming to finance. She served on Delta Air Lines Culinary Council as a nutrition consultant to help update and guide the airline's inflight menu planning for special meals and wellness initiatives.As a media spokesperson, Carolyn has worked with multiply leading brands including Nestle, The Wonderful Company, Quaker, Sunsweet, Danone, ConAgra and many others. Carolyn has been a professor of nutrition science and nutrition communication for Florida State University's London Study Centre and professor of journalism for Emory University in Atlanta.She is a contributor to NBC Atlanta & Company and can be seen as “The Lady of the Refrigerator” on Alton Brown's Good Eats on Food Network. Carolyn is the author of Southern Living's best selling The Slim Down South Cookbook and co-author of The Dish on Eating Healthy and Being Fabulous winner at the World Food Media awards.A pioneer in food television, Carolyn launched and led CNN's coverage of food andnutrition for nearly 20 years as anchor and executive producer of CNN On The Menu and was senior correspondent and anchor for CNN's Travel Now program. She's earned two James Beard Foundation Awards for excellence in broadcast food journalism and is a member of the James Beard Foundation's Who's Who in American Food and Beverage. She has also been honored by the National Restaurant Association, the American Heart Association, the American Society for Nutrition and the Academy of Nutrition and Dietetics for her pioneering work in nutrition communications. Her master's degree in nutrition is from Boston University and undergraduate degree in Foods and Nutrition is from Florida State University. Carolyn lives in Atlanta.
Thinking Transportation: Engaging Conversations about Transportation Innovations
Every four years, the American Society of Civil Engineers (ASCE) issues its Report Card for America's Infrastructure. Expressed in reader-friendly letter grades, the ratings document the current state of the country's major infrastructure assets, while also identifying needed improvements and contextualizing the relative health of these assets over time. Today, we talk to two experts--TTI's Edith Arámbula Mercado and the Texas Department of Transportation's Jamie Farris--about ASCE's 2025 report card and how Texas ranks nationally in terms of the health and reliability of its roads and bridges.
In this episode of the DermSurgery Digest, you'll hear a summary of the cosmetic and general dermatology articles in the July 2025 issue of Dermatologic Surgery followed by commentary from special guest contributors George Hruza,MD, and Yssra Soliman, MD. This podcast is hosted by Dermatologic Surgery Digital Content Editor, Naomi Lawrence, MD, and co-hosted by Michael Renzi, MD. Dermatologic Surgery is the official publication of the American Society for Dermatologic Surgery. In this podcast series the surgical oncology and reconstruction articles in the July issue of Dermatologic Surgery are featured in a separate episode. Your feedback is encouraged. Please contact communicationstaff@asds.net.
In this episode of the DermSurgery Digest, you'll hear a summary of the surgical oncology and reconstruction articles in the July 2025 issue of Dermatologic Surgery followed by commentary from special guest contributors Melissa Pugliano-Mauro, MD, and Sydney Proffer, MD, MS. This podcast is hosted by Dermatologic Surgery Digital Content Editor, Naomi Lawrence, MD, and co-hosted by Michael Renzi, MD. Dermatologic Surgery is the official publication of the American Society for Dermatologic Surgery. In this podcast series the cosmetic and general dermatology articles in the July issue of Dermatologic Surgery are featured in a separate episode. Your feedback is encouraged. Please contact communicationstaff@asds.net.
Before the ballpoint pen, people used their hands, reeds, bamboo, brushes, quills, and eventually nibs to write or draw. But how did things evolve from there to get to things like the fountain pen, and eventually, a ballpoint? Research: "pen." Britannica Library, Encyclopædia Britannica, 26 Jul. 2021. libraries.state.ma.us/login?eburl=https%3A%2F%2Flibrary.eb.com&ebtarget=%2Flevels%2Freferencecenter%2Farticle%2Fpen%2F59036&ebboatid=9265652. Accessed 13 Jun. 2025. "Pen." UXL Science, UXL, 2008. Gale In Context: Science, link.gale.com/apps/doc/CV2646000736/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=52ede570. Accessed 27 May 2025 “Patent of Mr. Frederick Bartholomew Folsch, of Oxford street, for improvements on instruments, and pens, to facilitate writing.” https://archive.org/details/jstor-30072521/mode/2up Bayley, Stephen. “Obituary: Baron Marcel Bich.” The Independent. 6/1/1994. https://www.independent.co.uk/news/people/obituary-baron-marcel-bich-1419867.html Bourque, Joseph. “The Waterman Pen.” American Heritage. Jul/Aug92, Vol. 43 Issue 4, p30. Brachmann, Steve. “The Evolution of Modern Ballpoint Pen: A Patent History.” IP Watchdog. 12/10/2014. https://ipwatchdog.com/2014/12/10/the-evolution-of-modern-ballpoint-pen-a-patent-history/id=52550/ Cross, Alonzo T. “Stylographic Pen.” U.S. Patent 232804. 10/5/1880. Daniels, Maygene. “The Ingenious Pen: American Writing Implements from the Eighteenth Century to the Twentieth.” The American Archivist , Summer, 1980, Vol. 43, No. 3 (Summer, 1980). Via JSTOR. https://www.jstor.org/stable/40292316 Di Nardo, Sam. “When was the Fountain Pen Invented: A Brief History.” Dayspring Pens. 1/2/2023. https://www.dayspringpens.com/blogs/the-jotted-line/when-was-the-fountain-pen-invented-a-brief-history-1 Di Nardo, Sam. “Who Invented the Ballpoint Pen?: A Brief History.” Sayspring Pens. s1/2/2023. https://www.dayspringpens.com/blogs/the-jotted-line/who-invented-the-ballpoint-pen-history?srsltid=AfmBOopQR061KHIKpgm_a0a0IHiTSiY_V-ahwIFQxU5MYzLLQ5vpHjXv Dowling, Stephen. “The cheap pen that changed writing forever.” BBC. 10/29/2020. https://www.bbc.com/future/article/20201028-history-of-the-ballpoint-pen German Patent and Trademark Office. “László Biró´s 125th birthday.” https://www.dpma.de/english/our_office/publications/milestones/inventionsthatmadehistory/kugelschreiber/index.html Laszlo, Josef Biro. “Writing Instrument.” U.S. patent 2390636. 12/11/1945. Loud, J.J. “Pen.” U.S. Patent 392046. 10/30/1888. National inventors Hall of Fame. “Laszlo Josef Biro.” https://www.invent.org/inductees/laszlo-josef-biro Riesberg, Van Vechton. “Fountain Pen.” U.S. Patent 1171652. 2/15/1916. Rothman, Lily. “Why the Invention of the Ballpoint Pen Was Such a Big Deal.” Time. 10/29/2015. https://time.com/4083274/ballpoint-pen/ The American Society of Mechanical Engineers. “#236 Birome Ballpoint Pen Collection.” https://www.asme.org/about-asme/engineering-history/landmarks/236-birome-ballpoint-pen-collection Waterman, L.E. “Fountain Pen.” U.S. Patent 293545. 2/12/1884. See omnystudio.com/listener for privacy information.
Sometimes it's not about eating less or moving more—it's about understanding what's really holding your body back. In this episode, I dive into five surprising reasons why you might not be losing weight—even when it feels like you're doing everything right. From the sneaky effects of stress and poor sleep, to the hidden dangers of under-eating, emotional eating, and overestimating your workouts, I break down what could be quietly sabotaging your progress. This isn't about blame—it's about awareness, compassion, and smart strategies to truly support your journey. Listen now to reclaim your power and finally move forward with confidence! Episode Highlights: 5 surprising reasons why weight loss might stall—even when you're doing everything right The role of stress and cortisol in fat storage How poor sleep disrupts hunger hormones and insulin sensitivity Why under-eating can slow your metabolism The truth about hidden calories and overestimating exercise Recognizing and managing emotional eating triggers Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
What’s Your Wrinkle®, the plastic surgery show with Dr. Arthur Perry
Each year the American Society of Plastic Surgeons releases stats on the most popular procedures. This year, the numbers were flat, but there were two huge surprises. On this show, we discuss the procedures that are losing popularity and one that plastic surgeons should not be doing at all. And..."do it yourself botulinum toxin" - it's here...and it's dangerous. Listen in...
New York Times bestselling author Adriana Trigiani is back to discuss her latest book, 'The View from Lake Como,' while reflecting on the importance of storytelling, the empowerment of women through literature, and the role of community in fostering a love for reading! She shares insights on the current state of reading among youth, the significance of creativity as an act of faith, and the value of altruism in the arts. More About Adriana and her latest work: Adriana Trigiani is the New York Times bestselling author of twenty-one books of fiction and nonfiction, including The Good Left Undone, The Shoemaker's Wife and Lucia, Lucia. Her work has been published in thirty-eight languages around the world. An award-winning playwright, television writer/producer, and filmmaker, Trigiani wrote and directed the major motion picture of her debut novel, Big Stone Gap, adapted her novel, Very Valentine, for television, and directed the award-winning documentary, Queens of the Big Time, among others. THE VIEW FROM LAKE COMO, which Dutton will publish in hardcover on July 8, 2025, is everything an immersive summer read should be—fresh, funny and heart-wrenching, with perfectly imperfect characters that readers will feel deeply connected to. With its vivid depiction of the complexities of familial relationships, this contemporary novel is a love letter to big Italian American families, Old World roots, and daughters who learn to live life on their own terms. Listen to Adriana's You Are What You Read podcast: https://linktr.ee/youarewhatyoureadpodcast Visit her website at www.adrianatrigiani.com This show is sponsored by BetterHelp. Give online therapy a try at https://betterhelp.com/jann and get 10% off your first month! Leave us a voicenote! https://jannardenpod.com/voicemail/ Get access to bonus content and more on Patreon: https://patreon.com/JannArdenPod Order ONLYJANNS Merch: https://cutloosemerch.ca/collections/jann-arden Connect with us: www.jannardenpod.com www.instagram.com/jannardenpod www.facebook.com/jannardenpod Chapters (00:00) Introduction to Adriana Trigiani and Her New Book (02:57) Reflections on American Society and the Importance of Faith (06:00) Character Development and the Writing Process (09:02) Making Stories Matter in Readers' Lives (12:13) Empowerment and Women's Narratives (14:56) The Role of Therapy in Personal Growth (18:01) The State of Reading Among Younger Generations (20:58) Community Engagement and the Importance of Libraries (24:01) The Impact of Technology on Reading Habits (26:59) The Power of Books and Their Influence on Society (29:18) The Power of Female Characters (30:06) Rebuilding Lives and Embracing Authenticity (31:26) Faith and the Creative Journey (35:25) The Importance of Connection (38:40) Defining Home and Connection Learn more about your ad choices. Visit megaphone.fm/adchoices
At times we have the opportunity to deviate a little from the tried-and-true conversations this podcast has become known for as opportunities occur for us to sit down with a very special person, perhaps not known as a sewist or quilter, but as someone who has made an indelible mark in the world of creativity. Our guest today is a woman whose life and work have helped shape some of the most iconic spaces and moments in American design history – and whose personal story is just as remarkable as her professional one.Tania McKnight Norris was born in Scotland and lived in London and Zimbabwe (then Southern Rhodesia) before relocating to Los Angeles in 1963. With a refined eye for detail, a love of elegance, and an independent spirit, she made her way to the United States and found herself working at the highest levels of interior design—at a time when few women were given a seat at the table.She joined the design team at Walt Disney Productions in the 1960s, becoming the only woman on the original five-person team responsible for creating the interiors of Disneyland's New Orleans Square and the elegant Club 33—an exclusive private club hidden behind an unmarked door that has since become the stuff of legend. Tania designed the club's original logo, handpicked furnishings, and helped shape its iconic look and feel, combining European sophistication with imaginative flair.Norris left Disney in the 70s, working as a project designer for the RMS Queen Mary before relocating to central California and opening an antique shop. She also anchored a weekly radio show about antiques and participated in antique shows throughout the United States while running her shop.Her interests include gardening, photography travel, cooking, needlepoint and botanical art – she is a member of the American Society of Botanical Artists.Today, Tania joins us to reflect on a life lived with imagination, strength, and purpose. From her early days as a curious girl in Scotland to becoming a design icon in her own right, she has so much to share—and we are honored to have her here to share it with us.(3:42) Tania shares stories of her youth…being born before WWII. She lived in a castle Culzean in Scotland which had a special floor that was given by the people of Scotland to President Eisenhower. Did you know that Scotland has palm trees along the coast. And that at the age of 8, Tania decided she wanted to decorate homes?! She even met Lady Churchill, Margo Fountain and the royal family. She arrived in America in November 1963, 2 weeks prior to the assassination of President Kennedy. She marveled at the resilience of this country. Then…there was THE call about the job at Disney. What follows is a rich recount of her early days at Disney.(13:30)Tania talks about Walt Disney and the gracious way he treated her. He “never said no” to her about her ideas. Learn what Disney would do if he didn't like someone's work…or wanted something more. And…how the ladies room got to be bigger than originally planned.(19:05) What's Tania's favorite attraction at Disney World! Find out here and why she chose this particular one. Learn about some of the behind-the-scenes things done at Disney World…things you probably never knew!(21:50) And now…the purple wallpaper. Tania tells of its creation.(24:46) Tania's hands have been reproduced many times at Disney. Hear this story and how much she was paid. Any why Mitzie Chandler got paid more.(26:22) What's it like for Tania to walk into a haunted mansion and see her work? What happened when she saw it on a maiden voyage of a Disney cruise ship?(27:33) Tania is a sewist. How did she learn to sew and what are her favorite things to make. How did WWII influence her sewing? And what's she up to with Joe Vecchiarelli?(33:10) Tania has visited +130 countries. Her some of her wonderful tales of adventures. Let's start with Antarctica. Then there's Mongolia where she saw the eclipse, Siberia for a wedding and Albania to interview students with whom she travelled to Macedonia. Oh, and what about 1000 miles down the Amazon.(35:02) Where has she not traveled to…but wants to go to…? West Africa and several places in Europe. Have toothbrush will travel!(35:37) She talks about her endowment for botanical art at the Huntington in San Marino. She explains why botanical art is so meaningful to her. She tells of the Virginia Robinson Gardens. She also explains botanical art.(38:30) Who is someone she's met in her life that really left an impression. Well…JoeVechiarelli…and Charles the King of England! Michael Jackson, Madonna.(40:12) What inspires her? Inquisitiveness! She tells of a dinner one night at the Getty Museum and…!(41:22) What's next for her? Retirement…most likely not!(41:53) What didn't I ask? Well, hear about her radio show The World of Books(43:14) How can you reach out to Tania? HMpurplewallpaper@gmail.com. Be sure to follow, rate and review this podcast on your favorite platform. Be sure to subscribe to, review and rate this podcast on your favorite platform…and visit our website sewandsopodcast.com for more information about today's and all of our Guests.
Recorded live at ASM Microbe 2025, this episode captures the energy of the American Society for Microbiology's annual event. Luis shares his top takeaways from the conference floor—including standout poster presentations, emerging technologies, and trending topics in microbiology. One clear theme dominated this year: rapid diagnostics for identification and susceptibility testing. Tune in for a front-row seat to the latest in clinical microbiology innovation. Questions? Feedback? Send those to letstalkmicro@outlook.com Want to support the podcast? Here's how: Venmo: https://venmo.com/u/letstalkmicro Buy me a Ko-fi: https://ko-fi.com/letstalkmicro
What would it take to reclaim your voice when every word is being scripted for you? This dystopian novel asks unsettling questions about love, loyalty, and the price of obedience in a world where no one lives past 50. Tune in for an inspiring discussion with Arielle Emmett, PhD, on her Nautilus award-winning novel The Logoharp: A Cyborg Novel of China and America in the Year 2121. Moments with Marianne airs in the Southern California area on KMET 1490AM & 98.1 FM, an ABC Talk News Radio Affiliate! https://www.kmet1490am.com Arielle Emmett, PhD, is a writer and science journalist specializing in East Asia, Africa, and cross- cultural interactions. She was a Contributing Editor to Smithsonian Air & Space magazine (2014-2021) and a Fulbright Scholar and Specialist in Kenya (2018-2019) and Indonesia (2015). A Mandarin and French speaker, Emmett has won prizes in magazine and journal competitions staged by the American Society of Journalists and Authors (ASJA) and the International Communications Association (ICA). She has reported and taught in China and Hong Kong, Taiwan, Indonesia, East Africa, Ireland, and Italy. Currently, she lives in North Carolina and travels frequently to see her three clever grandchildren. Emmett's debut novel is the first in a planned series on dystopian paths to utopian justice. https://leapingtigerpress.com Order The Logoharp on Amazon: https://a.co/d/2J1Ot8A For more show information visit: www.MariannePestana.com
Egg freezing (oocyte preservation) was once a medical procedure for patients facing infertility due to illness or surgery. In 2012, the American Society for Reproductive Medicine (ASRM) declared it “non-experimental,” making elective or social egg freezing more mainstream. Now widely used by Canadians seeking to delay parenthood for personal, career, or relationship reasons. Guest: Dr. Prati Sharma, American Board Certified Reproductive Endocrinologist Learn more about your ad choices. Visit megaphone.fm/adchoices
There are few people who have the depth and breadth of knowledge about long-term services and supports than Jennie Chin Hansen, who we are honored to have as the 300th guest on today's episode. With a rich background in nursing and a penchant for solving problems, Hansen's career spans decades of leading top healthcare organizations such as the American Geriatrics Society, AARP, and On Lok, which is the flagship/prototype for what is now known as People for All-Inclusive Care for the Elderly (PACE). She currently serves on the boards of the Medicare Advantage SCAN Health Plan and HelpAge USA. In 2019, she helped to craft the California Masterplan for Aging, now in implementation. For this week's episode, Hansen sits down with Susan Ryan to discuss how her childhood experience as an Asian girl living in Boston shaped her career choices. She also discusses her desire to see more upstream work that focuses getting “people prepared for their own aging changes.” Finally, Hansen shares her vision for what she believes will help to not only “hold the line,” but also move it with regard to ensuring economic security for older Americans. Among Hansen's many awards are the American Academy of Nursing's Health Care Leader Award, American Society on Aging's Hall of Fame Award, and the National Council on Aging's Lifetime Achievement Award. In 2024, she received an honorary Doctorate of Humane Letters degree from Harvard University at its commencement ceremony in May of 2024. Here is video of highlights from that event: https://youtu.be/lzDYU7sNddA?si=W0hGbEWsS8osCaRq.
Join host Geoffrey Rubin, MD, MBA, FACR, for a candid and wide-ranging conversation with Mitchell D. Schnall, MD, PhD, FACR—Professor of Radiology and Senior Vice President for Data and Technology Solutions at Penn Medicine. A highly accomplished radiology researcher and leader, Dr. Schnall served for 12 years as Vice Chair for Research in the Department of Radiology at the University of Pennsylvania, followed by another 12 years as Chair. His national leadership includes serving as Chair of ACRIN and the ACR Commission on Research, as well as President of the Academy for Radiology and Biomedical Imaging Research. His research contributions have earned him election to the American Society for Clinical Investigation, the Association of American Physicians, and the National Academy of Medicine. In this episode, Dr. Schnall reflects on his journey—from a curious kid with a ham radio license and an Ivy League gymnast to a nationally recognized leader in academic radiology. He shares how his background in physics and engineering shaped his hands-on approach to problem-solving, innovation, and leadership—including his early work developing MRI coils and his unexpected path into breast imaging research. Dr. Schnall also discusses lessons from his time leading Penn Radiology, his philosophy on team building and faculty development, and why embracing discomfort, trusting others, and taking smart risks are essential traits for effective leadership. With humility, clarity, and a touch of humor, Dr. Schnall offers valuable insights into the realities of leading in academic medicine, the importance of intellectual generosity, and the power of staying curious throughout one's career. Don't miss this thoughtful conversation with a leader who continues to shape the future of radiology—while never losing sight of the joy in figuring things out. Behind the Mic! Dr. Schnall and his wife have been married for 37 years. Together, they have a 32-year-old daughter, a 29-year-old son, and an 11-month-old granddaughter! When he's not working, Dr. Schnall loves to take things apart and put them back together. He is a serious “DIYer”, having renovated his own kitchen and multiple bathrooms at his home. He also enjoys riding his bicycle and eating spicey hot peppers!
Motivation may spark change, but it's small, consistent actions that keep the fire burning, especially when you're just not feeling it. In this episode, I talk about what to do when you're feeling completely unmotivated to stick with healthy habits. I dive into the truth that motivation is fleeting and often unreliable, and instead, I share practical strategies to keep moving forward even when you don't feel like it. I also explore common reasons we lose motivation like overwhelm, burnout, boredom, and perfectionism and offer five actionable tips: shrink the task, pair it with something enjoyable (habit stacking), reconnect with your "why," use the two-minute rule, and celebrate small wins. I remind you and myself—that consistency, not perfection, is what leads to lasting change. If you've ever struggled to stay on track with your healthy habits, this episode is your practical guide to getting unstuck—tune in now and take the first small step! Episode Highlights: The myth of constant motivation Common reasons for feeling unmotivated (overwhelm, burnout, perfectionism, etc.) Five practical strategies to take action when motivation is low The power of habit stacking and the two-minute rule Reconnecting with your "why" to stay grounded Celebrating small wins to build long-term momentum Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Dr. Renee Coffman is president and co-founder of the Nevada College of Pharmacy, now Roseman University of Health Sciences. She previously served as the University's Executive Vice President for Quality Assurance and Intercampus Consistency and the Dean of its College of Pharmacy. Before establishing Roseman University, Dr. Coffman became a founding member of the faculty at Western University of Health Sciences, where she also held the position of Facilitative Officer for Student Services. While at Western, Dr. Coffman and four colleagues received Honorable Mention for the AACP Innovations in Teaching Awards. A licensed pharmacist in the state of Nevada, Dr. Coffman earned a Pharmacy degree from OhioNorthern University in 1987 and, following graduation, worked as a pharmacist in her hometown of Bucyrus, Ohio and in Piqua, Ohio. In 1995, Dr. Coffman earned a doctoral degree in Industrial and Physical Pharmacy from Purdue University, where she received the Kienle Award for Excellence in Teaching, the Jenkins-Knevel Award for Outstanding Graduate Research, and was awarded an AAPE-AFPE Association Fellowship in Pharmaceutical Sciences.Dr. Coffman is a member of the American Association of Colleges of Pharmacy, American Pharmaceutical Association, American Association of Pharmaceutical Scientists, the American Society of Health System Pharmacists, and the International Federation of Pharmacy, as well as Phi Kappa Phi and Rho Chi Honor Societies and the Phi Lambda Sigma Pharmacy Leadership Society. Dr. Coffman has worked to support pharmacy, education, and improved health care through herwork with the Southern Nevada Medical Industry Coalition, iDO (Improving Diabetes and Obesity inSouthern Nevada), the Nevada State Board of Pharmacy Medication Error Discussion Group, and theNevada State Board of Pharmacy Committee on Standards for Approval of Pharmacy Technician Training Programs. Additionally, Dr. Coffman was instrumental in successful legislative efforts permitting pharmacists to perform finger-stick blood glucose testing. In recognition of her community service in Southern Nevada, in 2008, she received the “Who's Who in Healthcare” Award and the “Women of Distinction” Award, both sponsored by In Business Las Vegas, now VEGAS INC. In 2017, the publication recognized Dr. Coffman as one of 12 “Women to Watch” in business. In 2012, she was named a “Distinguished Alumnus” by Ohio Northern University and in 2021 was named a “Distinguished Alumnus” by Purdue University.
Summer Colling and Emma Wille speak with oncology experts Nkiru Ibeanu, Neha Anand, Anna Simmons and David Dahan about the 2025 American Society of Clinical Oncology (ASCO) conference. Deeper coverage is available through Datamonitor Healthcare
Get the truth about IVF from one of the world's most respected fertility doctors. In this episode of the Building Your Family podcast, we talk with Dr. Richard Paulson, former president of the American Society for Reproductive Medicine (ASRM) and a global leader in reproductive medicine. Dr. Paulson busts common fertility myths and offers practical, evidence-based suggestions on how to approach treatment, including what really matters when it comes to nutrition, supplements, and exercise. If you're trying to conceive or considering IVF, this episode is packed with expert insight you won't find on social media.
The hidden world of agricultural land management takes center stage as Morgan Ulmer, a seasoned land manager with Pifer's, pulls back the curtain on what happens after the seeds go into the ground. Racing from field to field across the entire Red River Valley, Morgan reveals how professional land managers become the eyes and ears for property owners who may live hundreds or thousands of miles from their agricultural investments.Morgan walks us through the meticulous process of field inspection—checking everything from water issues and weed pressure to crop health and projected yields. These detailed assessments, complete with extensive photography and documentation, ultimately form the backbone of comprehensive reports that keep landowners connected to their investments. "We have boots on the ground," Morgan explains, highlighting how land managers provide crucial peace of mind for distant property owners including trusts, family inheritances split between siblings, and investment groups.The conversation takes a sobering turn as Morgan describes the aftermath of recent catastrophic straight-line winds that devastated farms across portions of North Dakota. Machine sheds destroyed, grain bins toppled, and power poles snapped "like matchsticks" serve as stark reminders of agriculture's vulnerability to nature's fury. Yet through it all, Morgan notes the remarkable resilience of the farming community: "They're resilient people... they don't miss a beat" when it comes to cleanup and recovery efforts.The episode offers fascinating glimpses into the technological evolution of land management, from smartphone apps that estimate corn yields by photographing cobs to the game-changing deployment of drones for aerial inspection of difficult terrain. We also hear how land managers contribute valuable regional data to industry organizations like the American Society of Farm Managers and Rural Appraisers, helping establish crucial benchmarks for rental rates and agricultural trends across the region.Whether you're a landowner seeking better oversight of your agricultural investments, a farmer curious about professional management services, or simply interested in the behind-the-scenes work that supports modern agriculture, this episode delivers valuable insights into the vital role land managers play in protecting and optimizing one of our most precious resources.Follow at www.americalandauctioneer.com and on Instagram & FacebookContact the team at Pifer's
Kimmie Ng, MD, MPH, a JAMA associate editor and associate chief of the Division of Gastrointestinal Oncology at the Dana-Farber Cancer Institute, shares highlights from the American Society of Clinical Oncology's annual meeting, including new research on diet, exercise, and cancer survival and the best time of day for treatment. Related Content: Lifestyle and Cancer Survival, the Best Time of Day for Treatment, and More—Highlights From ASCO
Marketing a ketamine clinic presents unique challenges that traditional medical practices simply don't encounter. High advertising costs, frequent platform bans for ketamine-related content, and the need to build trust around an innovative treatment create significant barriers that demand a strategic approach.In this episode, Kim and Sam share the exact marketing framework they presented at the 2025 American Society of Ketamine Physicians, Psychotherapists & Practitioners conference in Austin - the same strategies that helped their clinic (Reset Ketamine) dominate "ketamine near me" searches and build a thriving practice since 2018. This isn't theoretical marketing advice pulled from generic healthcare playbooks. These are proven, field-tested strategies from clinician business owners like you - who've navigated the same platform restrictions, skeptical patients, and marketing obstacles that ketamine clinic owners face daily.What You'll Gain In This Episode:・The ACC funnel framework (Awareness, Consideration, Conversion) that transforms patient acquisition・How to create organic content that acts as your clinic's "vital sign" for trust and credibility・Why newsletters are the highest ROI marketing tool for ketamine practices and how to create themEpisode 35 show notes:00:00 Teaser - Organic content as your clinic's pulse00:32 Welcome to the Ketamine Startup Podcast01:25 Understanding the Medical Marketing Funnel (ACC)04:31 Awareness: The First Layer of the Funnel06:34 Consideration: Comparing Options07:15 Conversion: Turning Interest into Action09:23 What Is Organic Content?09:57 Push vs Pull10:44 The “What To Create” Venn Diagram12:49 The Content Creation Process14:55 How Organic Content Is A Clinic's Vital Sign17:20 The Power of Newsletters26:34 Conclusion and Key TakeawaysThanks for listeningWatch the YouTube Version with Visual SlidesFollow us onLinkedinYouTubeKetamine StartUp Website
Unlock the secrets to making the most of the American Society for Horticultural Science Annual Conference with insider tips from seasoned attendees. As the 2025 New Orleans conference approaches (July 28-August 1), discover strategies that transform overwhelming events into career-defining opportunities.Veteran conference-goer Curt Rom (46 conferences and counting!) and graduate student Samson Humphrey share perspectives on navigating everything from travel logistics to networking techniques. They reveal how to leverage the conference app to build a personalized schedule, position yourself for meaningful connections at poster sessions, and deliver polished presentations that showcase your research.The conversation goes beyond academic presentations to highlight often-overlooked opportunities like resume reviews that provide one-on-one career guidance, competitions that can earn recognition and rewards, and the critical importance of informal gatherings where "the real science often happens." Whether you are presenting research, seeking career opportunities, or simply looking to expand your professional network, this episode provides actionable strategies for every conference situation. The hosts emphasize that while the science is central, it's the relationships formed over beignets at Café Du Monde or during the annual 5K Fun Run that often prove most valuable to your career.Download the ASHS conference app today, build your profile, and start planning your personalized conference experience. https://ashs.org/page/ASHSAnnualConferenceLearn more about the American Society for Horticultural Science (ASHS) at https://ashs.org/.HortTechnology, HortScience and the Journal of the American Society for Horticultural Science are all open-access and peer-reviewed journals, published by the American Society of Horticultural Science (ASHS). Find them at journals.ashs.org.Consider becoming an ASHS member at https://ashs.org/page/Becomeamember!You can also find the official webpage for Plants, People, Science at ashs.org/plantspeoplesciencepodcast, and we encourage you to send us feedback or suggestions at https://ashs.org/webinarpodcastsuggestion. Podcast transcripts are available at https://plantspeoplescience.buzzsprout.com.On LinkedIn find Sam Humphrey at linkedin.com/in/samson-humphrey. Curt Rom is at https://www.linkedin.com/in/curt-rom-611085134/. Lena Wilson is at https://www.linkedin.com/in/lena-wilson-2531a5141/. Thank you for listening! ...
Why are the roads in Louisiana so bad? Do things like the heat, the weather, and the soil all factor in? Norma Jean Mattei, Professor of Engineering at UNO and a past president of the American Society of Civil Engineers, joins the show.
We all know that clinician burnout negatively impacts the quality of patient care. That's why pharmacy residency accrediting bodies now emphasize resident well-being and professional sustainability as core components of residency training earlier in clinician careers. The American Society of Health-System Pharmacists (ASHP) Accreditation Standards for PGY1 and PGY2 Pharmacy Residencies include a formal requirement for programs to address resilience, well-being, and burnout prevention, reflecting the increasing recognition of burnout in healthcare. Joining us to talk that out are Tony Huke, Senior Pharmacy Executive Director with Vizient Pharmacy Advisory Solutions and Kendra Gage, Inpatient Clinical Pharmacist and the PGY 1 Residency Program Director at UCHealth, University of Colorado Hospital in Aurora, Colorado. Guest speakers: Tony Huke, PharmD, BCPS, FASHP Senior Pharmacy Executive Director Vizient Pharmacy Advisory Solutions Kendra Gage, PharmD, BCPS Inpatient Clinical Pharmacist PGY1 Pharmacy Residency Program Director UCHealth Host: Kerry Schwarz, PharmD, MPH Senior Clinical Manager, Evidence-Based Medicine and Outcomes Center for Pharmacy Practice Excellence (CPPE) Show Notes: [01:11-03:25] What's new at the national level in terms of pharmacy resident resiliency and well-being [03:26-03:56] The intentionality of well-being in pharmacy residency programs [03:57-05:12] Examples from Kendra's program [05:13-06:40] Program expectations to address resilience [06:41-08:33] Assessment and potential metrics of resiliency programs [08:34-11:06] The role of pharmacy leadership and residency program directors in resiliency [11:07-12:34] Impact of resiliency programs so far Links | Resources: Accreditation Standards for PGY1 and PGY2 Pharmacy Residencies Subscribe Today! Apple Podcasts Amazon Podcasts Spotify Android RSS Feed
Summary In this episode of the Pain Exam Podcast, Dr. David Rosenblum provides a comprehensive review of herpes zoster and postherpetic neuralgia (PHN), focusing on pathophysiology, diagnosis, and treatment options. Dr. Rosenblum explains that postherpetic neuralgia affects approximately 25% of patients with acute herpes zoster, causing debilitating unilateral chronic pain in one or more dermatomes. He discusses the three phases of herpes zoster: acute (up to 30 days), subacute (up to 3 months), and postherpetic neuralgia (pain continuing beyond 3 months). Dr. Rosenblum identifies risk factors for developing PHN, including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. He details the pathophysiology involving peripheral and central sensitization, and explains different phenotypes of PHN that can guide treatment approaches. For treatment, Dr. Rosenblum reviews various options including antiviral medications (which should be started within 72 hours of onset), corticosteroids, opioids, antidepressants (particularly tricyclics and SNRIs), antiepileptics (gabapentin and pregabalin), topical agents (lidocaine and capsaicin), and interventional procedures such as epidural injections and pulsed radiofrequency. He emphasizes that prevention through vaccination with Shingrix is highly effective, with 97% effectiveness in preventing herpes zoster in patients 50-69 years old and 89% effectiveness in those over 70. Dr. Rosenblum mentions that he's currently treating a patient with trigeminal postherpetic neuralgia and is considering a topical sphenopalatine ganglion block as a minimally invasive intervention before attempting more invasive procedures. Chapters Introduction to the Pain Exam Podcast and Topic Overview Dr. David Rosenblum introduces the Pain Exam Podcast, mentioning that it covers painful disorders, alternative treatments, and practice management. He explains that this episode focuses on herpes zoster and postherpetic neuralgia as board preparation for fellows starting their programs, with ABA boards coming up in September. Dr. Rosenblum notes that he's not only preparing listeners for boards but also seeking the latest information to help treat his own patients with this notoriously difficult disease. Upcoming Conferences and Educational Opportunities Dr. Rosenblum announces several upcoming conferences including Aspen in July, Pain Week in September, and events with NYSIP and the Latin American Pain Society. He mentions he'll be teaching ultrasound and regenerative medicine at these events. Dr. Rosenblum invites listeners to sign up at nrappain.org to access a community discussing regenerative medicine, ultrasound-guided pain medicine, regional anesthesia, and board preparation. He also offers ultrasound training in New York and elsewhere, with upcoming sessions in Manhattan on July 12th and October 4th, plus private shadowing opportunities. Overview of Postherpetic Neuralgia Dr. Rosenblum defines postherpetic neuralgia as typically a unilateral chronic pain in one or more dermatomes after acute herpes zoster infection. He states that the incidence of acute herpes zoster ranges between 3-5 patients per thousand person-years, and one in four patients with acute herpes zoster-related pain will transition into postherpetic neuralgia. Dr. Rosenblum emphasizes that while this condition won't kill patients, it can be extremely debilitating and significantly reduce quality of life. Treatment Options Overview Dr. Rosenblum reviews treatment options according to the WHO pain ladder, including tricyclics like nortriptyline and antiepileptic drugs such as gabapentin. He explains that if pain is not significantly reduced, interventional treatments like epidural injections with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion are options. For postherpetic neuralgia specifically, Dr. Rosenblum notes that preferred treatments include transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics. Phases of Herpes Zoster and Definitions Dr. Rosenblum outlines the three phases during herpes zoster reactivation: acute herpes zoster-related pain (lasting maximum 30 days), subacute herpes zoster-related pain (pain after healing of vesicles but disappearing within 3 months), and postherpetic neuralgia (typically defined as pain continuing after 3 months). He mentions that acute herpes zoster pain often begins with prodromal pain starting a few days before the appearance of the rash. Incidence and Risk Factors Dr. Rosenblum states that the incidence of herpes zoster ranges between 3-5 patients per 1,000 person-years, with approximately 5-30% of cases leading to postherpetic neuralgia. He identifies risk factors including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. Dr. Rosenblum describes the clinical manifestations as a mosaic of somatosensory symptoms including burning, deep aching pain, tingling, itching, stabbing, often associated with tactile and cold allodynia. Impact on Quality of Life Dr. Rosenblum emphasizes that postherpetic neuralgia can be debilitating, impacting both physical and emotional functioning and causing decreased quality of life. He notes that it leads to fatigue, insomnia, depression, anorexia, anxiety, and emotional distress. Dr. Rosenblum stresses the importance of exploring methods for prevention of postherpetic neuralgia and optimizing pain treatment for both subacute herpes zoster-related pain and postherpetic neuralgia. Literature Review and Pathophysiology Dr. Rosenblum mentions that he's discussing a literature review from 2024 that updates previous practical guidelines published in 2011. He explains the pathophysiology of postherpetic neuralgia, which involves sensitization of peripheral and sensory nerves from damage. Dr. Rosenblum describes how inflammatory mediators reduce the stimulus threshold of nociceptors and increase responsiveness, resulting in pathological spontaneous discharges, lower thresholds for thermal and mechanical stimuli, and hyperalgesia. Central Sensitization and Nerve Damage Dr. Rosenblum explains that central sensitization results from peripheral nociceptor hyperactivity leading to plastic changes in the central nervous system, involving amplification of pain signals and reduced inhibition. He describes how nerve damage in postherpetic neuralgia patients results from neuronal death due to severe inflammatory stimuli or secondary to neuronal swelling. Dr. Rosenblum notes that motor defects occur in 0.05% of patients with herpes zoster, observed as abdominal pseudohernias or motor weakness of limbs limited to the affected myotome. Different Phenotypes and Classification Dr. Rosenblum discusses different phenotypes of postherpetic neuralgia and how phenotyping can determine treatment. He explains that there are several ways to classify the phenotypes, with one categorizing patients into three subtypes: sensory loss (most common), thermal gain, and thermal loss with mechanical gain. Dr. Rosenblum describes the mechanistic categorization, including the irritable nociceptive phenotype characterized by preserved sensation, profound dynamic mechanical allodynia, reduced pressure pain threshold, and relief with local anesthetic infiltration. Deafferentation Phenotype Dr. Rosenblum explains that a deafferentation phenotype may arise from destruction of neurons by the virus in the dorsal root ganglion. This phenotype is characterized by sensory loss, including thermal and vibratory sensation without prominent thermal allodynia. He notes that mechanical allodynia can occur secondary to A-beta fibers activating spinothalamic pathways (known as phenotypic switches), along with pressure hyperalgesia and temporal summation suggesting central sensitization. Dr. Rosenblum mentions that in one study, this phenotype was present in 10.8% of individuals, and for those with deafferentation pain, gabapentinoids, antidepressants, and neuromodulatory therapies like repetitive transcranial magnetic stimulation may be beneficial. Diagnosis and Physical Examination Dr. Rosenblum discusses the diagnosis of herpes zoster and postherpetic neuralgia, emphasizing the importance of physical examination. He explains that diagnosis is based on the rash, redness, papules, and vesicles in the painful dermatomes, with healing vesicles showing crust formation. Dr. Rosenblum notes that the rash is generally unilateral and does not cross the midline of the body. In postherpetic neuralgia patients, he mentions that scarring, hyper or hypopigmentation is often visible, with allodynia present in 45-75% of affected patients. Sensory Testing and Assessment Dr. Rosenblum explains that in patients with postherpetic neuralgia, a mosaic of somatosensory alterations can occur, manifesting as hyperalgesia, allodynia, and sensory loss. These can be quantified by quantitative sensory testing, which assesses somatosensory functions, dermal detection thresholds for perception of cold, warmth, and paradoxical heat sensations. He notes that testing can provide clues regarding underlying mechanisms of pain, impaired conditioned pain modulation, temporal summation suggesting central sensitization, and information about the type of nerve damage and surviving afferent neurons. Prevention Through Vaccination Dr. Rosenblum discusses prevention of acute herpes zoster through vaccination, noting that the risk increases with reduced immunity. He highlights studies evaluating Shingrix, a vaccine for herpes zoster, which showed 97% effectiveness in preventing herpes zoster in patients 50-69 years old with healthy immune systems and 89% effectiveness in patients over 70. Dr. Rosenblum states that Shingrix is 89-91% effective in preventing postherpetic neuralgia development in patients with healthy immune systems and 68-91% effective in those with weakened or underlying conditions. Treatment Objectives Dr. Rosenblum outlines the treatment objectives for herpes zoster and postherpetic neuralgia. For acute herpes zoster, objectives include relieving pain, reducing severity and duration of pain, accelerating recovery of epidermal defects, and preventing secondary infections. For postherpetic neuralgia, the objectives are pain alleviation and improved quality of life. Dr. Rosenblum lists available treatments including psychotherapy, opiates, antidepressants, antiepileptics, NMDA antagonists, topical agents, and interventional treatments such as epidurals, pulsed radiofrequency, nerve blocks, and spinal cord stimulation. Antiviral Medications Dr. Rosenblum emphasizes that antiviral drugs should be started within 72 hours of clinical onset, mentioning famciclovir, valacyclovir, and acyclovir. He notes there is no evidence for effectiveness after 72 hours in patients with uncomplicated herpes zoster. Dr. Rosenblum provides dosing information: for immunocompetent patients, famciclovir 500mg and valacyclovir 1000mg three times daily for seven days; for immunocompromised patients, famciclovir 1000mg three times daily for 10 days, while acyclovir should be given IV in the immunocompromised. Benefits of Antiviral Therapy Dr. Rosenblum explains that antiviral medication accelerates the disappearance of vesicles and crusts, promotes healing of skin lesions, and prevents new lesions from forming. By inhibiting viral replication, he notes that antiviral therapy likely reduces nerve damage, resulting in reduced incidence of postherpetic neuralgia, and should be started as soon as possible. Corticosteroids and Opioids Dr. Rosenblum discusses the use of corticosteroids, noting that when added to antiviral medications, they may reduce the severity of acute herpes zoster-related pain, though increased healing of skin lesions was not observed in one study. He mentions that a Cochrane review found oral corticosteroids ineffective in preventing postherpetic neuralgia. Regarding opioids, Dr. Rosenblum states they are commonly used alongside antivirals for controlling acute herpes zoster pain, with tramadol having a number needed to treat (NNT) of 4.7 and strong opioids having an NNT of 4.3 for 50% pain reduction. Methadone and Antidepressants Dr. Rosenblum discusses methadone as an NMDA receptor antagonist used in acute and chronic pain management, though he notes there are no randomized controlled trials determining its efficacy in acute herpes zoster pain or postherpetic neuralgia. He explains that methadone can modulate pain stimuli by inhibiting the uptake of norepinephrine and serotonin, resulting in decreased development of hyperalgesia and opioid tolerance, but has side effects including constipation, nausea, sedation, and QT prolongation that can trigger torsades de pointes. Dr. Rosenblum identifies antidepressants as first-line therapy for postherpetic neuralgia, including tricyclics and SNRIs, with tricyclics having an NNT of 3 and SNRIs an NNT of 6.4 for 50% pain reduction. Antiepileptics and Pharmacological Treatment Summary Dr. Rosenblum discusses antiepileptics like gabapentin and pregabalin for postherpetic neuralgia. He cites two trials measuring gabapentin's effect, concluding it was effective compared to placebo with a pooled NNT of 4.4, while pregabalin had an NNT of 4.9. Dr. Rosenblum summarizes that pharmacological treatment is well established for subacute herpes zoster pain, though new high-quality evidence has been lacking since the last update in 2011. Topical Agents Dr. Rosenblum discusses local anesthetic topical agents including lidocaine and capsaicin creams and patches. He notes that 8% capsaicin provided significant pain reduction during 2-8 weeks, while 5% lidocaine patches provided moderate pain relief after eight weeks of treatment. Dr. Rosenblum also mentions acute herpes zoster intracutaneous injections, citing a study where single intracutaneous injection with methylprednisolone combined with ropivacaine versus saline alone showed significant difference in VAS score at 1 and 4 weeks post-intervention favoring the intervention group. Intracutaneous Injections Dr. Rosenblum discusses the effect of repetitive intracutaneous injections with ropivacaine and methylprednisolone every 48 hours for one week. He cites a randomized control trial comparing antivirals plus analgesics to antivirals plus analgesics and repeat injections, finding the intervention group had significantly shorter duration of pain, lower VAS scores, and lower incidence of postherpetic neuralgia (6.4% vs 28% at 3 months). Dr. Rosenblum notes that a potential side effect of cutaneous methylprednisolone injection is fat atrophy, though this wasn't reported in the study. Summary of Local Anesthetics Dr. Rosenblum summarizes that there are no new studies reporting the efficacy of capsaicin 8% for postherpetic neuralgia, but it remains widely used in clinical practice and is approved in several countries. He notes that lidocaine patches can reduce pain intensity in patients with postherpetic neuralgia but may be more beneficial in patients with allodynia. Dr. Rosenblum adds that intracutaneous injections may be helpful for short periods, while repetitive injections with local anesthetics may reduce VAS scores for up to six months but can cause subcutaneous fat atrophy. Interventional Treatments: Epidural and Paravertebral Injections Dr. Rosenblum discusses interventional treatments, noting that previous guidelines found epidural injection with corticosteroids and local anesthetic as add-on therapy superior to standard care alone for up to one month in managing acute herpes zoster pain. He mentions a randomized controlled trial showing no difference between interlaminar and transforaminal epidural steroid injections for up to three months after the procedure. Dr. Rosenblum adds that previous guidelines reported high-quality evidence that paravertebral injections of corticosteroids or local anesthetic reduces pain in the active phase of herpes zoster. Comparative Studies on Injection Approaches Dr. Rosenblum discusses a trial comparing efficacy of repetitive paravertebral blocks with ropivacaine versus dexmedetomidine to prevent postherpetic neuralgia, which showed significantly lower incidence of zoster-related pain one month after therapy in the dexmedetomidine group, with effects still significant at three months. He also mentions a study comparing steroid injections administered via interlaminar versus transforaminal approaches, finding both groups had significantly lower VAS scores at 1 and 3 months follow-up compared to baseline, though this could align with the natural course of herpes zoster. Timing of Interventions and Continuous Epidural Blockade Dr. Rosenblum cites a retrospective study showing that transforaminal epidural injections administered for acute herpes zoster-related pain were associated with significantly shorter time to pain relief compared to those performed in the subacute phase. He also mentions a randomized controlled trial finding that continuous epidural blockade combined with opioids and gabapentin reduced NRS pain scores more than analgesic drug treatments alone during three-day follow-up, though both studies were low-quality. Interventions for Postherpetic Neuralgia Dr. Rosenblum discusses interventions specifically for postherpetic neuralgia, citing a small randomized controlled trial that demonstrated decreased NRS pain scores six months post-treatment for repeat versus single epidural steroid injections (15mg vs 5mg dexamethasone) administered over 24 days. The trial also found increased likelihood of complete remission during 6-month follow-up in the group receiving repeat epidural dexamethasone, though this was low-quality evidence. Summary of Epidural and Paravertebral Injections Dr. Rosenblum summarizes that epidural or paravertebral injections of local anesthetic and/or glucocorticoids could be considered in treating acute herpes zoster-related pain. For subacute postherpetic neuralgia pain, he notes low-quality evidence supporting epidural injections, while for postherpetic neuralgia, evidence supports continuous epidural infusion, though also of low quality. Dr. Rosenblum emphasizes that none of the included studies for postherpetic neuralgia investigating epidural or paravertebral injections resulted in decreased pain compared to standard therapy. Pulsed Radiofrequency (PRF) Evidence Dr. Rosenblum discusses pulsed radiofrequency (PRF), noting that previous guidelines indicated moderate quality evidence that PRF of the intercostal nerve reduces pain for 6 months in patients with postherpetic neuralgia, and very low-quality evidence that PRF to the dorsal root ganglion (DRG) reduces pain for 6 months. He mentions that multiple studies have been published since then assessing PRF efficacy. PRF Studies for Acute Herpes Zoster Dr. Rosenblum discusses a randomized controlled trial with 60 patients comparing high-voltage bipolar PRF of the cervical sympathetic chain versus sham, with treatment repeated after three days in both groups. He reports that VAS scores in the PRF group at each post-interventional point (1 day, 2 days, 1 month, 2 months, 3 months) were significantly lower than in the sham group, and at 3 months, the incidence of postherpetic neuralgia was 16.7% in the PRF group compared to 40% in the sham group. PRF for Trigeminal Neuralgia Dr. Rosenblum cites another randomized controlled trial evaluating high-voltage long-duration PRF of the Gasserian ganglion in 96 patients with subacute herpes-related trigeminal neuralgia, which found decreased VAS pain scores at all post-interventional time points (3, 7, 14 days and 1, 3, and 6 months) compared to the sham group. He also mentions a randomized comparative effectiveness study in 120 patients with subacute trigeminal herpes zoster, comparing a single application of high-voltage PRF to the Gasserian ganglion versus three cycles of conventional PRF treatment, finding significantly lower mean VAS pain scores for up to six months in the high-voltage PRF group. PRF Compared to Other Interventions Dr. Rosenblum discusses a randomized controlled trial comparing PRF to short-term spinal cord stimulation, which found decreased pain and improved 36-item short-form health survey scores in both groups at six months. He also mentions a randomized controlled trial in 72 patients where PRF of spinal nerves or peripheral branches of cranial nerves combined with five-day infusion of IV lidocaine resulted in greater pain reduction, less rescue analgesia, and reduced inflammatory cytokines at two months compared to PRF with saline infusions. Dr. Rosenblum notes a major limitation of this study was not accounting for the high natural recovery rate. Summary of PRF and Final Recommendations Dr. Rosenblum summarizes that PRF provides significant pain relief lasting over three months in patients with subacute herpes zoster and postherpetic neuralgia. He notes that since few studies have compared PRF versus sham, it's not possible to calculate an accurate number needed to treat. Dr. Rosenblum mentions there are no comparative studies comparing PRF to the intercostal nerves versus PRF of the DRG, but both preclinical and clinical studies suggest superiority of the DRG approach. He adds that evidence for spinal cord stimulation for postherpetic neuralgia is of low quality, and more research is needed given its invasive nature. Sympathetic Blocks and Conclusion Dr. Rosenblum notes there is low-quality evidence for using sympathetic blocks to treat acute herpes zoster-related pain, but no evidence for their use in postherpetic neuralgia. He mentions that risks of treatment with intrathecal methylprednisolone are unclear and therefore not recommended. Dr. Rosenblum concludes by praising the comprehensive article he's been discussing and mentions it provides insight for treating his patients, including a recent case of trigeminal postherpetic neuralgia. Personal Clinical Approach and Closing Dr. Rosenblum shares that he doesn't currently perform PRF in his practice, partly because it's not standard of care and not well reimbursed, creating barriers to implementation. However, he notes that PRF is a very safe procedure as it doesn't involve burning tissue. For his patient with trigeminal neuralgia pain, Dr. Rosenblum plans to try a topical sphenopalatine ganglion block as the least invasive intervention before considering injecting the trigeminal nerves at the foramen, in addition to pharmacotherapy. He concludes by thanking listeners, encouraging them to check the show notes and links, mentioning institutional memberships and shadowing opportunities, and asking listeners to rate and share the podcast. Q&A No Q&A session in this lecture Pain Management Board Prep Ultrasound Training REGISTER TODAY! Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care. As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 Dr. Rosenblum written several book chapters on Peripheral Neuromodulation, Radiofrequency Ablation, and Pharmacology. He has published numerous noteworthy articles and most recently is developing the ASIPP Guidelines for Peripheral Neuromodulation in the treatment of chronic pain. He has been named several times in NY Magazine's Best Pain Management Doctor List, Nassau County's Best Pain Physician, has appeared on NY1 News, and has made several appearances on XM Radio's Doctor Talk. He currently is lecturing on a national and international level and has partnered with the American Society of Interventional Pain Physicians (ASIPP), American Society of Pain and Neuroscience (ASPN), IASP Mexican Chapter, Eastern Pain Association (EPA), the North American Neuromodulation Society (NANS), World Academy of Pain Medicine United, as well as various other organizations, to support educational events and develop new courses. Since 2008, he has helped over 3000 physicians pass the Pain Management Boards, and has been at the forefront of utilizing ultrasound guidance to perform pain procedures. He now hosts the PainExam podcast, AnesthesiaExam Podcast, PMRExam Podcasts and uses this platform to promote the safe and effective use of ultrasound in the performance of various procedures such as Peripheral Nerve Stimulation, Caudal Epidurals, Selective Nerve Root Blocks, Cluneal Nerve Blocks, Ganglion impar Blocks, Stellate Ganglion Blocks, Brachial Plexus Blocks, Joint Injections and much more! Doctor Rosenblum created the NRAP (Neuromodulation Regional Anesthesia and Pain) Academy and travels to teach various courses focused on Pain Medicine, Regenerative Medicine, Ultrasound Guided Pain Procedures and Regional Anesthesia Techniques. Dr. Rosenblum is persistent when it comes to eliminating pain and has gained a reputation among his patients for thinking "outside the box" and implements ultrasound guidance to deposit medications, biologics (PRP, Bone Marrow Aspirate, etc.) and Peripheral Nerve Stimulators near pain generators. He is currently treating patients in his great neck and Brooklyn office. For an appointment go to AABPpain.com or call Brooklyn 718 436 7246 Reference Adriaansen, E. J., Jacobs, J. G., Vernooij, L. M., van Wijck, A. J., Cohen, S. P., Huygen, F. J., & Rijsdijk, M. (2025). 8. Herpes zoster and post herpetic neuralgia. Pain Practice, 25(1), e13423.
The UW-Madison Badger Pulling Team had an impressive performance at the American Society of Agricultural and Biological Engineers International Quarter-Scale Student Design Competition a few weeks ago. Stephanie Hoff, Ben Jarboe, and Kiley Allan went to see “Bossy” for themselves and took her for a spin! Team member Kaedyn Peterson-Rucker tells Stephanie about the desing process and competition.See omnystudio.com/listener for privacy information.
Summary In this episode of the Pain Exam Podcast, Dr. David Rosenblum provides a comprehensive review of herpes zoster and postherpetic neuralgia (PHN), focusing on pathophysiology, diagnosis, and treatment options. Dr. Rosenblum explains that postherpetic neuralgia affects approximately 25% of patients with acute herpes zoster, causing debilitating unilateral chronic pain in one or more dermatomes. He discusses the three phases of herpes zoster: acute (up to 30 days), subacute (up to 3 months), and postherpetic neuralgia (pain continuing beyond 3 months). Dr. Rosenblum identifies risk factors for developing PHN, including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. He details the pathophysiology involving peripheral and central sensitization, and explains different phenotypes of PHN that can guide treatment approaches. For treatment, Dr. Rosenblum reviews various options including antiviral medications (which should be started within 72 hours of onset), corticosteroids, opioids, antidepressants (particularly tricyclics and SNRIs), antiepileptics (gabapentin and pregabalin), topical agents (lidocaine and capsaicin), and interventional procedures such as epidural injections and pulsed radiofrequency. He emphasizes that prevention through vaccination with Shingrix is highly effective, with 97% effectiveness in preventing herpes zoster in patients 50-69 years old and 89% effectiveness in those over 70. Dr. Rosenblum mentions that he's currently treating a patient with trigeminal postherpetic neuralgia and is considering a topical sphenopalatine ganglion block as a minimally invasive intervention before attempting more invasive procedures. Chapters Introduction to the Pain Exam Podcast and Topic Overview Dr. David Rosenblum introduces the Pain Exam Podcast, mentioning that it covers painful disorders, alternative treatments, and practice management. He explains that this episode focuses on herpes zoster and postherpetic neuralgia as board preparation for fellows starting their programs, with ABA boards coming up in September. Dr. Rosenblum notes that he's not only preparing listeners for boards but also seeking the latest information to help treat his own patients with this notoriously difficult disease. Upcoming Conferences and Educational Opportunities Dr. Rosenblum announces several upcoming conferences including Aspen in July, Pain Week in September, and events with NYSIP and the Latin American Pain Society. He mentions he'll be teaching ultrasound and regenerative medicine at these events. Dr. Rosenblum invites listeners to sign up at nrappain.org to access a community discussing regenerative medicine, ultrasound-guided pain medicine, regional anesthesia, and board preparation. He also offers ultrasound training in New York and elsewhere, with upcoming sessions in Manhattan on July 12th and October 4th, plus private shadowing opportunities. Overview of Postherpetic Neuralgia Dr. Rosenblum defines postherpetic neuralgia as typically a unilateral chronic pain in one or more dermatomes after acute herpes zoster infection. He states that the incidence of acute herpes zoster ranges between 3-5 patients per thousand person-years, and one in four patients with acute herpes zoster-related pain will transition into postherpetic neuralgia. Dr. Rosenblum emphasizes that while this condition won't kill patients, it can be extremely debilitating and significantly reduce quality of life. Treatment Options Overview Dr. Rosenblum reviews treatment options according to the WHO pain ladder, including tricyclics like nortriptyline and antiepileptic drugs such as gabapentin. He explains that if pain is not significantly reduced, interventional treatments like epidural injections with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion are options. For postherpetic neuralgia specifically, Dr. Rosenblum notes that preferred treatments include transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics. Phases of Herpes Zoster and Definitions Dr. Rosenblum outlines the three phases during herpes zoster reactivation: acute herpes zoster-related pain (lasting maximum 30 days), subacute herpes zoster-related pain (pain after healing of vesicles but disappearing within 3 months), and postherpetic neuralgia (typically defined as pain continuing after 3 months). He mentions that acute herpes zoster pain often begins with prodromal pain starting a few days before the appearance of the rash. Incidence and Risk Factors Dr. Rosenblum states that the incidence of herpes zoster ranges between 3-5 patients per 1,000 person-years, with approximately 5-30% of cases leading to postherpetic neuralgia. He identifies risk factors including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. Dr. Rosenblum describes the clinical manifestations as a mosaic of somatosensory symptoms including burning, deep aching pain, tingling, itching, stabbing, often associated with tactile and cold allodynia. Impact on Quality of Life Dr. Rosenblum emphasizes that postherpetic neuralgia can be debilitating, impacting both physical and emotional functioning and causing decreased quality of life. He notes that it leads to fatigue, insomnia, depression, anorexia, anxiety, and emotional distress. Dr. Rosenblum stresses the importance of exploring methods for prevention of postherpetic neuralgia and optimizing pain treatment for both subacute herpes zoster-related pain and postherpetic neuralgia. Literature Review and Pathophysiology Dr. Rosenblum mentions that he's discussing a literature review from 2024 that updates previous practical guidelines published in 2011. He explains the pathophysiology of postherpetic neuralgia, which involves sensitization of peripheral and sensory nerves from damage. Dr. Rosenblum describes how inflammatory mediators reduce the stimulus threshold of nociceptors and increase responsiveness, resulting in pathological spontaneous discharges, lower thresholds for thermal and mechanical stimuli, and hyperalgesia. Central Sensitization and Nerve Damage Dr. Rosenblum explains that central sensitization results from peripheral nociceptor hyperactivity leading to plastic changes in the central nervous system, involving amplification of pain signals and reduced inhibition. He describes how nerve damage in postherpetic neuralgia patients results from neuronal death due to severe inflammatory stimuli or secondary to neuronal swelling. Dr. Rosenblum notes that motor defects occur in 0.05% of patients with herpes zoster, observed as abdominal pseudohernias or motor weakness of limbs limited to the affected myotome. Different Phenotypes and Classification Dr. Rosenblum discusses different phenotypes of postherpetic neuralgia and how phenotyping can determine treatment. He explains that there are several ways to classify the phenotypes, with one categorizing patients into three subtypes: sensory loss (most common), thermal gain, and thermal loss with mechanical gain. Dr. Rosenblum describes the mechanistic categorization, including the irritable nociceptive phenotype characterized by preserved sensation, profound dynamic mechanical allodynia, reduced pressure pain threshold, and relief with local anesthetic infiltration. Deafferentation Phenotype Dr. Rosenblum explains that a deafferentation phenotype may arise from destruction of neurons by the virus in the dorsal root ganglion. This phenotype is characterized by sensory loss, including thermal and vibratory sensation without prominent thermal allodynia. He notes that mechanical allodynia can occur secondary to A-beta fibers activating spinothalamic pathways (known as phenotypic switches), along with pressure hyperalgesia and temporal summation suggesting central sensitization. Dr. Rosenblum mentions that in one study, this phenotype was present in 10.8% of individuals, and for those with deafferentation pain, gabapentinoids, antidepressants, and neuromodulatory therapies like repetitive transcranial magnetic stimulation may be beneficial. Diagnosis and Physical Examination Dr. Rosenblum discusses the diagnosis of herpes zoster and postherpetic neuralgia, emphasizing the importance of physical examination. He explains that diagnosis is based on the rash, redness, papules, and vesicles in the painful dermatomes, with healing vesicles showing crust formation. Dr. Rosenblum notes that the rash is generally unilateral and does not cross the midline of the body. In postherpetic neuralgia patients, he mentions that scarring, hyper or hypopigmentation is often visible, with allodynia present in 45-75% of affected patients. Sensory Testing and Assessment Dr. Rosenblum explains that in patients with postherpetic neuralgia, a mosaic of somatosensory alterations can occur, manifesting as hyperalgesia, allodynia, and sensory loss. These can be quantified by quantitative sensory testing, which assesses somatosensory functions, dermal detection thresholds for perception of cold, warmth, and paradoxical heat sensations. He notes that testing can provide clues regarding underlying mechanisms of pain, impaired conditioned pain modulation, temporal summation suggesting central sensitization, and information about the type of nerve damage and surviving afferent neurons. Prevention Through Vaccination Dr. Rosenblum discusses prevention of acute herpes zoster through vaccination, noting that the risk increases with reduced immunity. He highlights studies evaluating Shingrix, a vaccine for herpes zoster, which showed 97% effectiveness in preventing herpes zoster in patients 50-69 years old with healthy immune systems and 89% effectiveness in patients over 70. Dr. Rosenblum states that Shingrix is 89-91% effective in preventing postherpetic neuralgia development in patients with healthy immune systems and 68-91% effective in those with weakened or underlying conditions. Treatment Objectives Dr. Rosenblum outlines the treatment objectives for herpes zoster and postherpetic neuralgia. For acute herpes zoster, objectives include relieving pain, reducing severity and duration of pain, accelerating recovery of epidermal defects, and preventing secondary infections. For postherpetic neuralgia, the objectives are pain alleviation and improved quality of life. Dr. Rosenblum lists available treatments including psychotherapy, opiates, antidepressants, antiepileptics, NMDA antagonists, topical agents, and interventional treatments such as epidurals, pulsed radiofrequency, nerve blocks, and spinal cord stimulation. Antiviral Medications Dr. Rosenblum emphasizes that antiviral drugs should be started within 72 hours of clinical onset, mentioning famciclovir, valacyclovir, and acyclovir. He notes there is no evidence for effectiveness after 72 hours in patients with uncomplicated herpes zoster. Dr. Rosenblum provides dosing information: for immunocompetent patients, famciclovir 500mg and valacyclovir 1000mg three times daily for seven days; for immunocompromised patients, famciclovir 1000mg three times daily for 10 days, while acyclovir should be given IV in the immunocompromised. Benefits of Antiviral Therapy Dr. Rosenblum explains that antiviral medication accelerates the disappearance of vesicles and crusts, promotes healing of skin lesions, and prevents new lesions from forming. By inhibiting viral replication, he notes that antiviral therapy likely reduces nerve damage, resulting in reduced incidence of postherpetic neuralgia, and should be started as soon as possible. Corticosteroids and Opioids Dr. Rosenblum discusses the use of corticosteroids, noting that when added to antiviral medications, they may reduce the severity of acute herpes zoster-related pain, though increased healing of skin lesions was not observed in one study. He mentions that a Cochrane review found oral corticosteroids ineffective in preventing postherpetic neuralgia. Regarding opioids, Dr. Rosenblum states they are commonly used alongside antivirals for controlling acute herpes zoster pain, with tramadol having a number needed to treat (NNT) of 4.7 and strong opioids having an NNT of 4.3 for 50% pain reduction. Methadone and Antidepressants Dr. Rosenblum discusses methadone as an NMDA receptor antagonist used in acute and chronic pain management, though he notes there are no randomized controlled trials determining its efficacy in acute herpes zoster pain or postherpetic neuralgia. He explains that methadone can modulate pain stimuli by inhibiting the uptake of norepinephrine and serotonin, resulting in decreased development of hyperalgesia and opioid tolerance, but has side effects including constipation, nausea, sedation, and QT prolongation that can trigger torsades de pointes. Dr. Rosenblum identifies antidepressants as first-line therapy for postherpetic neuralgia, including tricyclics and SNRIs, with tricyclics having an NNT of 3 and SNRIs an NNT of 6.4 for 50% pain reduction. Antiepileptics and Pharmacological Treatment Summary Dr. Rosenblum discusses antiepileptics like gabapentin and pregabalin for postherpetic neuralgia. He cites two trials measuring gabapentin's effect, concluding it was effective compared to placebo with a pooled NNT of 4.4, while pregabalin had an NNT of 4.9. Dr. Rosenblum summarizes that pharmacological treatment is well established for subacute herpes zoster pain, though new high-quality evidence has been lacking since the last update in 2011. Topical Agents Dr. Rosenblum discusses local anesthetic topical agents including lidocaine and capsaicin creams and patches. He notes that 8% capsaicin provided significant pain reduction during 2-8 weeks, while 5% lidocaine patches provided moderate pain relief after eight weeks of treatment. Dr. Rosenblum also mentions acute herpes zoster intracutaneous injections, citing a study where single intracutaneous injection with methylprednisolone combined with ropivacaine versus saline alone showed significant difference in VAS score at 1 and 4 weeks post-intervention favoring the intervention group. Intracutaneous Injections Dr. Rosenblum discusses the effect of repetitive intracutaneous injections with ropivacaine and methylprednisolone every 48 hours for one week. He cites a randomized control trial comparing antivirals plus analgesics to antivirals plus analgesics and repeat injections, finding the intervention group had significantly shorter duration of pain, lower VAS scores, and lower incidence of postherpetic neuralgia (6.4% vs 28% at 3 months). Dr. Rosenblum notes that a potential side effect of cutaneous methylprednisolone injection is fat atrophy, though this wasn't reported in the study. Summary of Local Anesthetics Dr. Rosenblum summarizes that there are no new studies reporting the efficacy of capsaicin 8% for postherpetic neuralgia, but it remains widely used in clinical practice and is approved in several countries. He notes that lidocaine patches can reduce pain intensity in patients with postherpetic neuralgia but may be more beneficial in patients with allodynia. Dr. Rosenblum adds that intracutaneous injections may be helpful for short periods, while repetitive injections with local anesthetics may reduce VAS scores for up to six months but can cause subcutaneous fat atrophy. Interventional Treatments: Epidural and Paravertebral Injections Dr. Rosenblum discusses interventional treatments, noting that previous guidelines found epidural injection with corticosteroids and local anesthetic as add-on therapy superior to standard care alone for up to one month in managing acute herpes zoster pain. He mentions a randomized controlled trial showing no difference between interlaminar and transforaminal epidural steroid injections for up to three months after the procedure. Dr. Rosenblum adds that previous guidelines reported high-quality evidence that paravertebral injections of corticosteroids or local anesthetic reduces pain in the active phase of herpes zoster. Comparative Studies on Injection Approaches Dr. Rosenblum discusses a trial comparing efficacy of repetitive paravertebral blocks with ropivacaine versus dexmedetomidine to prevent postherpetic neuralgia, which showed significantly lower incidence of zoster-related pain one month after therapy in the dexmedetomidine group, with effects still significant at three months. He also mentions a study comparing steroid injections administered via interlaminar versus transforaminal approaches, finding both groups had significantly lower VAS scores at 1 and 3 months follow-up compared to baseline, though this could align with the natural course of herpes zoster. Timing of Interventions and Continuous Epidural Blockade Dr. Rosenblum cites a retrospective study showing that transforaminal epidural injections administered for acute herpes zoster-related pain were associated with significantly shorter time to pain relief compared to those performed in the subacute phase. He also mentions a randomized controlled trial finding that continuous epidural blockade combined with opioids and gabapentin reduced NRS pain scores more than analgesic drug treatments alone during three-day follow-up, though both studies were low-quality. Interventions for Postherpetic Neuralgia Dr. Rosenblum discusses interventions specifically for postherpetic neuralgia, citing a small randomized controlled trial that demonstrated decreased NRS pain scores six months post-treatment for repeat versus single epidural steroid injections (15mg vs 5mg dexamethasone) administered over 24 days. The trial also found increased likelihood of complete remission during 6-month follow-up in the group receiving repeat epidural dexamethasone, though this was low-quality evidence. Summary of Epidural and Paravertebral Injections Dr. Rosenblum summarizes that epidural or paravertebral injections of local anesthetic and/or glucocorticoids could be considered in treating acute herpes zoster-related pain. For subacute postherpetic neuralgia pain, he notes low-quality evidence supporting epidural injections, while for postherpetic neuralgia, evidence supports continuous epidural infusion, though also of low quality. Dr. Rosenblum emphasizes that none of the included studies for postherpetic neuralgia investigating epidural or paravertebral injections resulted in decreased pain compared to standard therapy. Pulsed Radiofrequency (PRF) Evidence Dr. Rosenblum discusses pulsed radiofrequency (PRF), noting that previous guidelines indicated moderate quality evidence that PRF of the intercostal nerve reduces pain for 6 months in patients with postherpetic neuralgia, and very low-quality evidence that PRF to the dorsal root ganglion (DRG) reduces pain for 6 months. He mentions that multiple studies have been published since then assessing PRF efficacy. PRF Studies for Acute Herpes Zoster Dr. Rosenblum discusses a randomized controlled trial with 60 patients comparing high-voltage bipolar PRF of the cervical sympathetic chain versus sham, with treatment repeated after three days in both groups. He reports that VAS scores in the PRF group at each post-interventional point (1 day, 2 days, 1 month, 2 months, 3 months) were significantly lower than in the sham group, and at 3 months, the incidence of postherpetic neuralgia was 16.7% in the PRF group compared to 40% in the sham group. PRF for Trigeminal Neuralgia Dr. Rosenblum cites another randomized controlled trial evaluating high-voltage long-duration PRF of the Gasserian ganglion in 96 patients with subacute herpes-related trigeminal neuralgia, which found decreased VAS pain scores at all post-interventional time points (3, 7, 14 days and 1, 3, and 6 months) compared to the sham group. He also mentions a randomized comparative effectiveness study in 120 patients with subacute trigeminal herpes zoster, comparing a single application of high-voltage PRF to the Gasserian ganglion versus three cycles of conventional PRF treatment, finding significantly lower mean VAS pain scores for up to six months in the high-voltage PRF group. PRF Compared to Other Interventions Dr. Rosenblum discusses a randomized controlled trial comparing PRF to short-term spinal cord stimulation, which found decreased pain and improved 36-item short-form health survey scores in both groups at six months. He also mentions a randomized controlled trial in 72 patients where PRF of spinal nerves or peripheral branches of cranial nerves combined with five-day infusion of IV lidocaine resulted in greater pain reduction, less rescue analgesia, and reduced inflammatory cytokines at two months compared to PRF with saline infusions. Dr. Rosenblum notes a major limitation of this study was not accounting for the high natural recovery rate. Summary of PRF and Final Recommendations Dr. Rosenblum summarizes that PRF provides significant pain relief lasting over three months in patients with subacute herpes zoster and postherpetic neuralgia. He notes that since few studies have compared PRF versus sham, it's not possible to calculate an accurate number needed to treat. Dr. Rosenblum mentions there are no comparative studies comparing PRF to the intercostal nerves versus PRF of the DRG, but both preclinical and clinical studies suggest superiority of the DRG approach. He adds that evidence for spinal cord stimulation for postherpetic neuralgia is of low quality, and more research is needed given its invasive nature. Sympathetic Blocks and Conclusion Dr. Rosenblum notes there is low-quality evidence for using sympathetic blocks to treat acute herpes zoster-related pain, but no evidence for their use in postherpetic neuralgia. He mentions that risks of treatment with intrathecal methylprednisolone are unclear and therefore not recommended. Dr. Rosenblum concludes by praising the comprehensive article he's been discussing and mentions it provides insight for treating his patients, including a recent case of trigeminal postherpetic neuralgia. Personal Clinical Approach and Closing Dr. Rosenblum shares that he doesn't currently perform PRF in his practice, partly because it's not standard of care and not well reimbursed, creating barriers to implementation. However, he notes that PRF is a very safe procedure as it doesn't involve burning tissue. For his patient with trigeminal neuralgia pain, Dr. Rosenblum plans to try a topical sphenopalatine ganglion block as the least invasive intervention before considering injecting the trigeminal nerves at the foramen, in addition to pharmacotherapy. He concludes by thanking listeners, encouraging them to check the show notes and links, mentioning institutional memberships and shadowing opportunities, and asking listeners to rate and share the podcast. Q&A No Q&A session in this lecture Pain Management Board Prep Ultrasound Training REGISTER TODAY! Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care. As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 Dr. Rosenblum written several book chapters on Peripheral Neuromodulation, Radiofrequency Ablation, and Pharmacology. He has published numerous noteworthy articles and most recently is developing the ASIPP Guidelines for Peripheral Neuromodulation in the treatment of chronic pain. He has been named several times in NY Magazine's Best Pain Management Doctor List, Nassau County's Best Pain Physician, has appeared on NY1 News, and has made several appearances on XM Radio's Doctor Talk. He currently is lecturing on a national and international level and has partnered with the American Society of Interventional Pain Physicians (ASIPP), American Society of Pain and Neuroscience (ASPN), IASP Mexican Chapter, Eastern Pain Association (EPA), the North American Neuromodulation Society (NANS), World Academy of Pain Medicine United, as well as various other organizations, to support educational events and develop new courses. Since 2008, he has helped over 3000 physicians pass the Pain Management Boards, and has been at the forefront of utilizing ultrasound guidance to perform pain procedures. He now hosts the PainExam podcast, AnesthesiaExam Podcast, PMRExam Podcasts and uses this platform to promote the safe and effective use of ultrasound in the performance of various procedures such as Peripheral Nerve Stimulation, Caudal Epidurals, Selective Nerve Root Blocks, Cluneal Nerve Blocks, Ganglion impar Blocks, Stellate Ganglion Blocks, Brachial Plexus Blocks, Joint Injections and much more! Doctor Rosenblum created the NRAP (Neuromodulation Regional Anesthesia and Pain) Academy and travels to teach various courses focused on Pain Medicine, Regenerative Medicine, Ultrasound Guided Pain Procedures and Regional Anesthesia Techniques. Dr. Rosenblum is persistent when it comes to eliminating pain and has gained a reputation among his patients for thinking "outside the box" and implements ultrasound guidance to deposit medications, biologics (PRP, Bone Marrow Aspirate, etc.) and Peripheral Nerve Stimulators near pain generators. He is currently treating patients in his great neck and Brooklyn office. For an appointment go to AABPpain.com or call Brooklyn 718 436 7246 Reference Adriaansen, E. J., Jacobs, J. G., Vernooij, L. M., van Wijck, A. J., Cohen, S. P., Huygen, F. J., & Rijsdijk, M. (2025). 8. Herpes zoster and post herpetic neuralgia. Pain Practice, 25(1), e13423.
Shadd Maruna is Head of the Department of Sociology, Social Policy & Criminology at the University of Liverpool. His research focuses on how individuals desist from crime and reintegrate into society, emphasizing the transformative power of identity and narrative. Shadd's influential book, Making Good, introduced the concept of the “redemption script,” reshaping our understanding of desistance. He served as President of the American Society of Criminology in 2023.
Mike Sager is an American author, journalist, and educator.A former Washington Post staff writer, Rolling Stone contributing editor, and writer at large for GQ, Sager has been a contributing writer for Esquire for more than three decades. In 2010 he received the American Society of Magazine Editors' National Magazine award for profile writing for his story "The Man Who Never Was," which appeared in Esquire. He is the author of more than a dozen books, and has served as an editor on several journalism text books. Sager has read and lectured at American schools of journalism. In 2012 he founded The Sager Group LLC, a content brand with a variety of functions ranging from publishing to film making, to general marketing.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-opperman-report--1198501/support.
Antibody drug conjugates, or ADCs, are still holding on to their spot as one of the hottest areas in cancer care—and AbbVie, like many of its peers, has embraced the trend head-on. In this week’s episode of "The Top Line," Fierce Pharma’s Zoey Becker speaks with Daejin Abidoye, M.D., AbbVie’s vice president and therapeutic area head for solid tumor oncology. They discuss the company’s evolution, trends from this year’s American Society of Clinical Oncology meeting and what’s ahead for ADCs in oncology. AbbVie, a newer player in the ADC space, recently earned FDA approval for Emrelis in adults with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who have previously received systemic therapy. With a robust pipeline of ADCs in development, Abidoye envisions a bright future for the class—one that could herald “a new era” of cancer treatment beyond traditional chemotherapy. To learn more about the topics in this episode: AbbVie advances solid tumor agenda with FDA nod for lung cancer ADC Emrelis AbbVie pays $10B to acquire ImmunoGen, doubling down on red-hot ADC cancer field Replacing chemotherapy with ADCs? AbbVie rebuilds next-gen assets after Rova-T flop See omnystudio.com/listener for privacy information.
“United States soybean seed protein concentrations – current status, challenges and some potential crop management solutions” with Dr. Anuj Chiluwal. Soybeans are a crucial crop in the United States for a variety of uses, including for its use as a protein source in animal feed. However, in recent years, high yield varieties have seen a steady decline in seed protein concentration. In this episode, Anuj joins me to discuss the sources of this decline and some potential strategies to combat it. Tune in to learn: · Why soybean seed protein is declining in US soybean · How the US may be a template for other countries with similar problems · What temporary solutions may be available for this problem · Which future research paths may bring about more sustainable solutions If you would like more information about this topic, this episode's paper is available here: https://doi.org/10.1002/agj2.21731 This paper is always freely available. Contact us at podcast@sciencesocieties.org or on Twitter @FieldLabEarth if you have comments, questions, or suggestions for show topics, and if you want more content like this don't forget to subscribe. If you'd like to see old episodes or sign up for our newsletter, you can do so here: https://fieldlabearth.libsyn.com/. If you would like to reach out to Anuj, you can find him here: anuj.chiluwal@kysu.edu https://www.kysu.edu/directory/faculty-staff/anuj-chiluwal.php https://www.linkedin.com/in/anuj-chiluwal/ Resources CEU Quiz: Coming soon Transcripts: https://www.rev.com/app/captions/Njg1MWI0MjE2MDAzODViYzNhZjVkNjYzWE4wOEZYc1pLNHNQ/o/Q1AwMTA4NTk3MzE4 “Soybean management for seed composition: The perspective of U.S. farmers” paper: https://doi.org/10.1002/agj2.21082 “Exploring Nitrogen Limitation for Historical and Modern Soybean Genotypes” paper: https://doi.org/10.2134/agronj2018.04.0271 “Quantification of Soybean Leaf Senescence and Maturation as Impacted by Soil- and Foliar-Applied Nitrogen” paper: https://doi.org/10.2134/cftm2018.07.0051 “Probability of Yield Response to Inoculants in Fields with a History of Soybean” paper: https://doi.org/10.2135/cropsci2009.04.0185 “Late-Season Nitrogen Applications Increase Soybean Yield and Seed Protein Concentration” paper: https://doi.org/10.3389/fpls.2021.715940 “Is soybean yield limited by nitrogen supply?” paper: https://doi.org/10.1016/j.fcr.2017.08.009 “Assessing Variation in US Soybean Seed Composition (Protein and Oil)” paper: https://doi.org/10.3389/fpls.2019.00298 “Regional analysis of planting date and cultivar maturity recommendations that improve soybean oil yield and meal protein concentration” paper: https://doi.org/10.3389/fpls.2022.954111 Extension fact sheet: https://www.kysu.edu/documents/college-of-agriculture-communities-the-sciences/2025-Fact%20Sheet%20Soybean%20Seed%20Quality.pdf University of Minnesota annual soybean quality reports: https://extension.umn.edu/soybean/soybean-seed-quality Thank you to our volunteer Om Prakash Ghimire for help with the shownotes and other assets. Thank you to Cole Shalk from 12twelve Media for the Audio Processing on today's episode. Field, Lab, Earth is Copyrighted by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.
In the 94th episode of the WGI Unleashed podcast, we're excited to introduce you to Chris Velasquez, EIT, a Senior Graduate Engineer in our Civil + Land Development Team based out of WGI's San Antonio, TX office! Join us as hosts Dan and Katie travel to the Alamo City to sit down with Chris for a spirited, insightful, and entertaining conversation filled with compelling career highlights, hilarious anecdotes, and fascinating behind-the-scenes stories from Chris's unique journey within the architecture, engineering, and construction (AEC) industry. From Curiosity to Engineering Excellence Chris's passion for engineering and innovation sparked long before his professional career began, and his journey to where he is today is anything but conventional. Born in New Jersey but raised in Rosenberg, Texas, Chris humorously recounts his childhood experiences growing up in a quiet subdivision, jokingly referring to it as "the hood." His curiosity and keen problem-solving abilities were evident from a young age. On the podcast, Chris shares vivid memories of his school years, including an unusual educational structure where sixth, seventh, and eighth grades each had their own separate buildings, and his early fascination with engineering, sparked by hands-on high school classes in aerospace, mechanical, and civil engineering. College Triumphs and Steel Bridge Competitions Chris chose to attend the University of Texas at San Antonio (UTSA), balancing the desire for independence with proximity to family. At UTSA, Chris actively participated in the American Society of Civil Engineers' Steel Bridge Competition, where his team repeatedly secured regional wins and competed nationally against some of the most prestigious universities in the country! Internship Experiences and Transition to WGI Chris gained valuable experience through internships, initially exploring public works before discovering WGI through a UTSA career fair. His humorous anecdote about initially confusing WGI with a color guard organization highlights his amicable personality and underscores his seamless fit within WGI's culture. His internship at WGI proved instrumental, smoothly transitioning him into a full-time role upon graduation, thanks to the mentorship of colleagues in the public works team. From Intern to Influencer Over four years at WGI, Chris has grown from an eager intern to a respected Senior Graduate Engineer. He reflects on his professional development, noting how he now actively mentors new team members and interns. Chris highlights how each project presents unique challenges, making every day exciting and engaging. He emphasizes how teamwork and a supportive environment have significantly contributed to his personal and professional growth at WGI. Life Beyond The Office Outside work, Chris enthusiastically shares his love for chicken wings, especially lemon pepper wings cooked in an air fryer, proudly noting his dislike of chicken nuggets. He also humorously recounts the San Antonio office tradition of participating in the "Hot Ones" spicy wings challenge, despite his aversion to spicy foods, simply because he "doesn't like giving up." What Makes WGI Special Chris quickly points out that what makes WGI stand out is its remarkable people and collaborative spirit. "At WGI, you're more than just an employee - you're part of a close-knit community genuinely invested in your growth and success," Chris shares, emphasizing the nurturing and supportive company culture that inspires everyone to reach their highest potential. Tune In This episode is packed with unforgettable moments - from conquering UTSA's Steel Bridge competitions and navigating spicy wing challenges in the San Antonio office, to mentoring the next generation of engineers and solving real-world infrastructure problems with heart and humor. So, tune in, and as always, stay curious, stay driven, and keep unleashing your full potential! Visit your favorite podcast app now and subscribe to WGI Unleashed to receive alerts every time a new episode drops. You can find us on Spotify, Apple Podcasts, iHeart Radio, or wherever you find your favorite podcasts.
For decades, the U.S. has prioritized the four-year degree path, but millions of workers thrive through alternative routes. In this episode, Kyle Hayes, Senior Director of Public Policy at the American Society of Association Executives (ASAE), joins host Jason Altmire to discuss how one bipartisan proposal could fundamentally change workforce preparation. The Freedom to Invest in Tomorrow's Workforce Act would allow families to use 529 Savings Plans to fund short-term credentials, career training, and workforce development programs. With strong bipartisan support and minimal federal cost, this policy shift could be the key to unlocking more affordable, practical education pathways for millions.To learn more about Career Education Colleges & Universities, visit our website.
Did you know that one 20-ounce soda can pack more sugar than five donuts—and still leave you hungry? In this episode, I unpacked the deceptively sweet world of sugar-sweetened beverages from sodas and sweet teas to fruit juices and even those “healthy” smoothies. I busted eight common myths that might be sabotaging your wellness journey without you even realizing it. We talked about how liquid calories sneak past your hunger cues, spike blood sugar, fuel cravings, and trigger fat storage. I broke down why fruit juice isn't the same as whole fruit, why diet sodas and energy drinks aren't a free pass, and why even your favorite boba tea might be more dessert than drink. So whether you're sipping flavored coffee or reaching for coconut water, it's time to start reading those labels. My challenge to you? Swap one sugary drink a day for water or an unsweetened alternative, your body will thank you for it. Ready to take control of your cravings, boost your energy, and finally see results on the scale? Tune in now to uncover the hidden truths about sweetened drinks and start making smarter choices that truly support your health goals! Episode Highlights: The hidden impact of sugar-sweetened beverages on weight gain and metabolic health Why liquid calories don't satisfy hunger and often lead to overeating Eight common myths about sweet drinks—busted with science The truth about fruit juice, diet sodas, smoothies, and boba tea How sweet drinks spike blood sugar, insulin, and fat storage Smarter alternatives to hydrate without sabotaging your health Practical tips to reduce sweet drink intake and improve energy, mood, and weight loss Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Join Elevated GP: www.theelevatedgp.com Follow @dental_digest_podcast Instagram Follow @dr.melissa_seibert on Instagram Dr. Margeas was recently named on the 2024 "32 Most Influential People in Dentistry" by Incisal Edge Magazine. Click here to learn more! Dr. Margeas graduated from the University of Iowa College of Dentistry in 1986 and completed his AEGD residency the following year. He is currently an adjunct professor in the department of Operative Dentistry at the University of Iowa. He is Board Certified by the American Board of Operative Dentistry. He is a Diplomate of the American Board of Aesthetic Dentistry, a Fellow of the Academy of General Dentistry, American Society for Dental Aesthetics and International Team of Oral implantologists (ITI). He has written numerous articles on esthetic and implant dentistry, and lectures and presents hands-on courses nationally and internationally on those subjects. He is currently the Editor in Chief of Inside Dentistry, on the Editorial Board of Compendium, and is a contributing editor to Oral Health in Canada. His memberships include OKU Honor Dental Society, American Academy of Esthetic Dentistry, and the American Academy of Restorative Dentistry. Dr. Margeas maintains a full-time private practice focusing on comprehensive restorative and implant dentistry in Des Moines, Iowa.
- Introduction to the Broadcast and Song Premiere (0:10) - Song Lyrics and Philosophical Arguments (2:30) - Geopolitical Analysis and Land Grab (10:31) - Breakaway Civilization and Advanced Technology (32:29) - Economic and Strategic Importance of LA (41:19) - Conclusion and Call to Action (41:41) - Humanitarian Rights and Political Power (1:06:48) - Deportation as a Humanitarian Act (1:29:38) - Comparing Illegal Immigration to Trespassing (1:31:22) - The Impact of Illegal Immigration on American Society (1:35:22) - The Role of Compassion and Law in Deportation (1:36:47) - Emergency Preparedness and Satellite Communication (1:42:24) - The Importance of Communication in Emergencies (1:44:58) - The Growth of Starlink and Its Benefits (1:55:29) - Preparing for Natural Disasters and Conflicts (2:15:22) - Supporting American Businesses and Preparedness (2:20:12) For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we're helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency. ▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com
Developer conference season is almost over, but we've got one show left to see: Apple's WWDC begins on Monday. Nilay, David, and Joanna Stern spend time going through both what they expect to see at the show, and why this year's WWDC might feel a bit different than in years past. Apple is in a tricky place with regulators, developers, and users alike, and has some genuine explaining to do. After that, they talk about the launch of the Nintendo Switch 2, and David's surprisingly easy adventure to acquire one. We also have a bit of smart glasses and AI gadgets news to discuss, so we do that too. Then it's time for Brendan Carr is a Dummy, and an update on a couple of the interesting new fediverse projects launching this week. Further reading: Verge subscriptions are on sale 40 percent off American Society of Magazine Editors Announces National Magazine Awards 2025 Winners Apple ordered to keep web links in the App Store Payment companies team up to help developers ditch App Store billing Apple could be adding camera controls and sleep detection to your AirPods Switch 2 launch: where to find restocks online and in-store Look inside the Nintendo Switch 2 with the console's first teardown Mario Kart World's designers had to rethink everything to make it open world Nintendo is updating even more games for the Switch 2 Here's what's inside Meta's experimental new smart glasses Meta's reportedly shopping for exclusive content on its upcoming VR headset Meta reportedly sidelined ‘Quest 4' designs for a goggles-like mixed-reality headset FCC investigation looms over EchoStar's missed interest payments and a new satellite From Ars Technica: FCC Republican resigns, leaving agency with just two commissioners Jony Ive's OpenAI device gets the Laurene Powell Jobs nod of approval ChatGPT's goal is to be a ‘super assistant' for every part of your life Email us at vergecast@theverge.com or call us at 866-VERGE11, we love hearing from you. Help us plan for the future of The Vergecast by filling out a brief survey: voxmedia.com/survey. Learn more about your ad choices. Visit podcastchoices.com/adchoices