Podcasts about ADT

Frieda Möcker, Head of People & Culture at Sastrify, joined us on The Modern People Leader. We talked about the first steps she took to treat HR more like a product, how her team does sprint planning, and why she prefers “NCTs” over OKRs.---- Sponsor Links:

  What if your journey to becoming a physician didn't come with the burden of student debt, and instead, offered unique career opportunities and a profound sense of purpose? Join us as we chat with Army LTC Mary Alice Noel, MD, Navy CAPT Shauna F. O'Sullivan, DO, and Air Force Col Brian Neubauer, MD, to uncover the transformative power of the Health Professions Scholarship Program (HPSP). These esteemed guests share how the program not only covers full medical school tuition and provides a monthly stipend, but also opens doors to a diverse array of career paths in military medicine, offering a rewarding way to serve one's country.     Our discussion doesn't stop at financial benefits; it dives deep into the commitments and training opportunities that come with the HPSP. We unravel the journey through military medical training, from officer training schools to active duty for training (ADT) activities, and the unique advantages of being a Medical Corps officer during residency. You'll hear about the high match rates in military Graduate Medical Education (GME), the opportunities to pursue desired specialties, and the robust support systems that ensure both professional and personal growth.    The episode also highlights the rewarding nature of military deployments, beyond the traditional roles, with stories of humanitarian missions and crisis support. Learn about the vast opportunities available to military physicians, including roles in aviation and space, and the collaborative environments that enhance career development. Whether you're considering a future in military medicine or are just curious about the path less taken, this conversation is packed with insights and experiences that illustrate the immense fulfillment and camaraderie found in serving as a military physician. Chapters: (00:04) Health Professions Scholarship Program Overview (13:54) Military Medical Training and Benefits (24:30) Military GME and Residency Opportunities (36:54) Additional Training Opportunities (44:49) Military Medicine Career Opportunities (54:48) Military Medicine Deployments (01:04:15) Military Medicine Tribute and Resources   Chapter Summaries: (00:04) Health Professions Scholarship Program Overview   HPSP fully funds medical school for military physicians, offering financial benefits, unique training opportunities, and collaborative nature of military medicine.   (13:54) Military Medical Training and Benefits   HPSP journey includes officer training, ADT, service obligations, and benefits during residency for aspiring military medical officers.   (24:30) Military GME and Residency Opportunities   Military GME process for HPSP students includes a separate match, active duty tours, and high match rates for desired specialties.   (36:54) Additional Training Opportunities   Air Force physicians have various opportunities in residency, fellowships, and careers in clinical, academic, command, and integrated operations.   (44:49) Military Deployment and Career Opportunities   Nature's multifaceted military deployments offer diverse opportunities for training and career tracks, including GME and operational care for soldiers.   (54:48) Military Medicine Deployments   The HPSP offers financial freedom, unique deployment experiences, and leadership development in military medicine.   (01:04:15) Military Medicine Tribute and Resources   We thank all American service members and their families, highlighting their patriotism and invite listeners to explore the WarDocs podcast to find out more about the history and proud legacy of Military Medicine.     Take Home Messages: Financial Benefits of HPSP: The Health Professions Scholarship Program (HPSP) offers substantial financial advantages for aspiring military physicians, including full tuition coverage for medical school and a monthly stipend. This program offers the opportunity to graduate without the burden of student debt, making it an attractive option for those interested in pursuing a medical career within the military.   Diverse Training Opportunities: Military medicine offers unique training experiences, such as active duty for training (ADT) and clinical rotations at military hospitals across the country. These experiences, along with the opportunity to participate in both military and civilian residency programs, provide HPSP participants with a comprehensive and competitive medical education.   Career Pathways in Military Medicine: The military medical career offers a variety of pathways, including clinical, academic, command, and integrated operations roles. This flexibility allows physicians to explore different aspects of medicine and leadership within the Army, Navy, and Air Force.   Deployment and Humanitarian Roles: Military deployments offer rewarding experiences beyond traditional combat roles, including humanitarian assignments and support for civilian institutions during crises. These roles provide a sense of purpose and camaraderie, highlighting the impact military physicians can have on a global scale.   Comprehensive Support During Residency: Military Medical Corps officers benefit from competitive salaries, comprehensive insurance, and generous leave policies during residency. These benefits create a supportive environment that balances professional growth with personal life, ensuring the well-being of military physicians and their families.   Link for more information: Navy:  Navy HPSP: https://www.med.navy.mil/Accessions/Health-Professions-Scholarship-Program-HPSP-and-Financial-Assistance-Program-FAP/ Navy Medicine Recruiting - https://www.navy.com/careers-benefits/careers/medical/physician Navy Medical Corps - https://www.med.navy.mil/Medical-Corps/ Army: Army HPSP: https://www.goarmy.com/careers-and-jobs/specialty-careers/medical/amedd-scholarships Air Force: Air Force HPSP: https://www.airforcemedicine.af.mil/Organizations/Physician-Education-Branch/Medical-School-Scholarships/ Air Force Medical Corps: https://www.airforcemedicine.af.mil/About-Us/Medical-Branches/Medical-Corps/ Graduate Medical Education (GME): DHA GME Website: https://www.health.mil/Military-Health-Topics/DHA-GME Navy GME - https://www.med.navy.mil/Naval-Medical-Leader-and-Professional-Development-Command/Professional-Development/Graduate-Medical-Education/   Episode Keywords: Military Medicine, HPSP, Health Professions Scholarship Program, Medical Education, Army Medical Corps, Navy Medicine, Air Force Physicians, Medical Career, Military Hospitals, Military Match System, Graduate Medical Education, Medical Residency, Military Deployment, Humanitarian Assignments, Operational Roles, Military Scholarships, Medical Corps Officer, War Docs Podcast, Medical Training Opportunities   Hashtags: #MilitaryMedicine #HPSP #MedicalEducation #MilitaryCareer #ArmyNavyAirForce #HealthcareScholarship #MedicalTraining #WarDocsPodcast #MilitaryPhysicians #GraduateMedicalEducation     Honoring the Legacy and Preserving the History of Military Medicine The WarDocs Mission is to honor the legacy, preserve the oral history, and showcase career opportunities, unique expeditionary experiences, and achievements of Military Medicine. We foster patriotism and pride in Who we are, What we do, and, most importantly, How we serve Our Patients, the DoD, and Our Nation.   Find out more and join Team WarDocs at https://www.wardocspodcast.com/ Check our list of previous guest episodes at https://www.wardocspodcast.com/our-guests Subscribe and Like our Videos on our YouTube Channel: https://www.youtube.com/@wardocspodcast Listen to the “What We Are For” Episode 47. https://bit.ly/3r87Afm   WarDocs- The Military Medicine Podcast is a Non-Profit, Tax-exempt-501(c)(3) Veteran Run Organization run by volunteers. All donations are tax-deductible and go to honoring and preserving the history, experiences, successes, and lessons learned in Military Medicine. A tax receipt will be sent to you. WARDOCS documents the experiences, contributions, and innovations of all military medicine Services, ranks, and Corps who are affectionately called "Docs" as a sign of respect, trust, and confidence on and off the battlefield,demonstrating dedication to the medical care of fellow comrades in arms.     Follow Us on Social Media Twitter: @wardocspodcast Facebook: WarDocs Podcast Instagram: @wardocspodcast LinkedIn: WarDocs-The Military Medicine Podcast YouTube Channel: https://www.youtube.com/@wardocspodcast

ROH, MLW and GCW resultsBecome a supporter of this podcast: https://www.spreaker.com/podcast/nsc-wrestling-and-gaming-podcast--4855340/support.

Tiffany Stevenson (Former CPO, WeightWatchers), Jennifer Rettig (CPO, Pendo.io), and Kelli Dragovich (4x CHRO & Co-host of HR Heretics), joined us for MPL Live in San Francisco.We talked about the pressure HR leaders are under, what CEOs are really thinking, and how we can reimagine performance with simpler systems, clearer expectations, and more human conversations.---- Sponsor Links:

On this week's episode: Dice Coach Dials In Dice Sets Demons House Edge We also touch on sniping, 2-V mutant, ADT, negative progressions, black jack, stop loss and Ed teaches us some Greek. Call The Casino Tears Vent Line 229-NO SEVEN (667-3836) Now! Leave a message, ask a question or simply get something off your mind -  We might even play it on air!! NEW EPISODES DROP WEEKLY ON TUESDAYS - Please visit our home page at casinotears.com for more info, merch, and host contacts Extended versions will also drop Tuesdays on Patreon - Don't miss out :) Email: noseven@casinotears.com Patreon: https://www.patreon.com/CasinoTears Pro Shop: https://www.casinotears.vegas/shop/  Instagram: https://www.instagram.com/casinotearspodcast YouTube: https://www.youtube.com/@CasinoTears X: https://x.com/CasinoTears Reddit: https://www.reddit.com/r/casinotears  

Jessica Zwaan joined us again on The Modern People Leader to break down how to hire for a people ops as a product team.She shared the 5 core skillsets needed, the importance of t-shaped talent, and how to use case studies to spot product thinking in HR Candidates.---- Sponsor Links:

Nick James discusses intriguing data from STAMPEDE to us AI to analyze pathology slides to predict benefit from ADT + abiraterone

Alison and Amanda talk about the routine of renting clothes, curious encounters with customer support, savvy shopping strategies, and the days of dialing for time.  Sis & Tell, an award-winning weekly comedic podcast, is hosted by southern Jewish sisters the Emmy-nominated Alison Goldstein Lebovitz from PBS' The A List and Time Magazine's 2006 Person of the Year, Comedian Amanda Goldstein Marks.

Matt McFarlane and Haris Ikram joined us for a live session to break down everything modern HR leaders need to know about compensation—from philosophy and strategy to pay transparency and AI tools. Together, they shared a forward-thinking playbook for tackling merit cycles, aligning job architecture, and driving better employee experiences through data and design.---- Sponsor Links:

My guest this week is DeLu Jackson, Executive Vice President and Chief Marketing and Communications Officer at ADT. A seasoned executive with over 20 years of experience, DeLu has led marketing transformation at some of the world's most iconic brands, including McDonald's, Audi, Kellogg's, Nissan, Subaru, ConAgra, and now ADT. He's known for his data-driven, customer-first approach and for helping redefine what protection and connection mean in the smart home and small business security space. With an undergraduate degree in Politics from Princeton University and an MBA from NYU Stern School of Business, he brings both intellectual rigor and real-world results to the table. He's also an independent board director and a recognized thought leader in marketing, growth, and digital innovation. 

My guest today is Nigel Jones who is making his third appearance on the Tribe Sober podcast – our conversations always get plenty of downloads and Nigel is a mine of valuable information! In this episode:- Nigel's secret to success was becoming a non-drinker from Day One — rather than a drinker trying to quit. He used the metaphor of a mountain — put yourself on top from the start rather than struggling to climb it. It's our beliefs and values shape our identity, then it's our identity that drives our intentions and actions. We need to flip our beliefs: once we truly believe that alcohol is a poison, then everything changes. Nigel is a qualified Hypnotherapist and he came up with a great analogy to explain how hypnotherapy works Our conscious mind is often resistant and has “bouncers” to prevent new information from entering our subconscious Hypnotherapy can remove those bouncers allowing better access to the subconscious Drinking creates a program in our subconscious and hypnotherapy helps us to replace it with healthier programs. Nigel is also qualified in NLP - Neuro Linguistic Programming which can help us to rewire our beliefs We both agreed that Drinking is deeply tribal — Nigel calls the Alcohol Drinking Tribe the ADT People protect their ADT which is why we often encounter resistance when we announce that we have quit drinking When we leave the ADT, we need to find another tribe quickly so that we don't feel isolated or judged In fact Connection is the opposite of addiction and That's why we set up Tribe Sober which offers connection, vulnerability, and authenticity  – so if you're ready to swop your drinking tribe for Tribe Sober then click here to check out our membership program Nigel shares his own inspiring story called Walking Back to Happiness He's also a certified hypnotherapist, NLP practitioner and life coach. He offers 1:1 and group coaching, for habit change, phobias, and anxiety. His website and social media is 9kmby9am.com  Nigel's previous podcast interviews with Tribe Sober are here and here   Episode Sponsor This episode is sponsored by the Tribe Sober Membership Program.  If you want to change your relationship with alcohol then sign up today - here is the link.  Help us to spread the word! We made this podcast so that we can reach more people who need our help.  Please subscribe and share. We release a podcast episode every Saturday morning. You can follow Tribe Sober on Facebook, Twitter and Instagram.  You can join our private Facebook group HERE PS: How to Leave a Rating/Review in Apple Podcasts (on an iOS Device) Open the Podcasts app. EASY. Choose “Search” from the bottom row of icons and enter the name of the show (e.g. Recover Like a Mother) into the search field. Select the show under Shows (not under Episodes). Scroll down past the first few episodes until you see Ratings & Reviews. Click Write a Review underneath the displayed reviews from other listeners. You'll then have the option to rate the show on a 5-star scale and write a review (you can rate without writing too but it's always good to read your experience).  

Abby Brennan joined us on The Modern People Leader. We discussed the power of ONA as the “shadow org chart,” how it reveals hidden influencers, and why it may be key to building smarter, more connected teams in the age of AI.---- Sponsor Links:

You should know this: The common approach to prostate cancer is NOT the best path for your long-term health. In this episode, Dr. Stephen Petteruti uncovers essential truths behind President Joe Biden's prostate cancer diagnosis. Dr. Stephen critically examines conventional treatments, such as androgen deprivation therapy (ADT), highlighting their severe side effects. He also challenges the long-held medical belief linking testosterone to cancer progression, presenting innovative and less harmful alternative treatments.Discover safer, science-backed alternatives your doctor might not mention. It's time to take control of your health with knowledge, clarity, and confidence.Don't miss this episode: Biden's Prostate Cancer: The TRUTH Doctors Don't Want You To Know!Enjoy the podcast? Subscribe and leave a 5-star review!Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website: www.intellectualmedicine.com  YouTube: https://www.youtube.com/@dr.stephenpetteruti LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/ Instagram: instagram.com/dr.stephenpetteruti Disclaimer:  The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.#CastrationCrisis #ProstateCancer #ProstateChoices

AUA2025: Embracing Multi-Disciplinary Care for Advanced Prostate Cancer: A Case-Based Update 2025 CME Available: https://auau.auanet.org/node/42997 At the conclusion of this activity, participants will be able to: 1. Initial Management of Metastatic Prostate Cancer: Evaluate and treat a patient with new diagnosed M1 prostate cancer with androgen deprivation therapy (ADT) plus be skilled to offer novel oral antiandrogens. Furthermore, to recognize high-volume new M1 prostate cancer so as to be able to partner with GU medical oncologist for docetaxel chemotherapy in a multidisciplinary team. 2. Non-Metastatic Castrate Resistant Prostate Cancer (M0 CRPC): The learner will be skilled to diagnose M0 CRPC and be able to educate patients about using either enzalutamide or apalutamide or darolutamide added to traditional ADT as a way to improve their patent's overall and radiographic progression-free survival. Furthermore, the skilled learner will be able to understand the differences between these three oral agents and to educate patients about side-effects and toxicities. Finally, understand the pros and cons of PSMA PET scan imaging in further staging in this disease Non-metastatic Castrate-Resistant Prostate Cancer (M0 CRPC): Diagnose M0 CRPC and be able to educate patients about using novel oral antiandrogens added to traditional ADT as a way to improve their patent's overall and radiographic progression-free survival. Furthermore, the skilled learner will be able to understand the differences between these novel oral agents and to educate patients about side effects and toxicities. Finally, understand the pros and cons of PSMA PET scan imaging in further staging in this disease state. 3. Metastatic Castrate-Resistant Prostate Cancer (M1 CRPC): Describe and have a working knowledge of the latest phase III RCT results for new therapies in M1 CRPC and be able to educate their patients on treatment options and participate in a multidisciplinary team caring for men with this disease state of far-advanced prostate cancer. 4. Describe that advanced prostate cancer is a complex group of disease states with an ever-changing therapeutic landscape and for providers and teams to embrace the multi-disciplinary nature of care for our patients. 5. Identify the molecular and molecular genetic underpinnings of advanced prostate cancer and recognize the future will be based on a more personalized therapy landscape including PARP inhibition, immune checkpoint agents, and novel AR targeted agents emerging in 2025 and beyond.

On this episode of the podcast, cancer researcher, physician, and author Dr. Steven Quay dives into President Joe Biden's recent cancer disclosure and sheds light on his broader medical history — including brain aneurysms, pulmonary embolisms, and past cancers. Dr. Quay breaks down the slow progression of prostate cancer, raising questions about the timing and transparency of Biden's newly revealed diagnosis. He also highlights the importance of PSA screenings after age 50 and explores the risks and benefits of androgen deprivation therapy (ADT).Furthermore, Dr. Quay discusses his forthcoming book, “The Code as Witness: The COVID Genome Reveals Its Lab Origins and How to Prevent Future Outbreaks,” where he makes the case for COVID's lab-based origins and calls for a federal ban on gain-of-function research to prevent future pandemics.Follow Dr. Steven Quay on X by searching for his handle: @Quay_Dr and learn more at www.DrQuay.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jessica Zwaan joined us again on The Modern People Leader to unpack how to structure a people ops as a product team. She shared four ways to build an HR squad, how to use a spider diagram for squad design, and why it's smart to pilot just one squad first.---- Sponsor Links:

这是一个独属于女性的夜晚。4月27日，耐克全球女子夜跑系列赛After Dark Tour来到上海，3500名女性跑者在南京东路集结，将上海的夜「跑为己有」。10公里结束，她们在跑百巷再次聚首，聊聊这段旅程中的汗水、成长与感动。本期节目，运动博主孙佳祺、赵依侬客串我们的代班主播，和跑龄两个月的「老跑者」颜如晶、在训练过程里能同时拥有天使和魔鬼两幅面孔的小彩教练，以及20位参赛跑者一起「续摊儿」，不仅回味了一番After DarkTour强烈的后劲，还有轻松的跑步趣事和坚韧的女性内核：当我们穿上跑鞋，不只是踏上赛道，更是在一步步中靠近那个更坚定、更自由的自己。- 聊天的人 -代班主播：孙佳祺、赵依侬嘉宾：颜如晶，耐克女子夜跑参赛者小彩，耐克NRC 城市教练ADT参赛者和跑者- 时间轴 -01:47 After Dark Tour之后，跑百巷迎来一场「全女局」05:19 颜如晶：为了准备这场10K，我先去跑了个半马10:14 从「厌跑」到半马，是怎么一步步跑起来的18:43 参加ADT的跑者们，发枪前后的反差也太大了28:26 全女赛事的特别之处？垃圾很少，还香香的32:45 在舞台一样的赛道上跑步，是种什么体验？36:32 这是属于我的勋章，不需要任何人帮忙戴上37:43 在这个夜晚，女性之间的温暖连结悄然发生39:27 夜跑的「危险」主要体现在...夜宵的诱惑？49:00 夜幕降临，正是探索城市新样貌的好时机53:36 虽然都说不忘初心，但过程有时更有意义01:01:15 不用比较，跑步是一项完全由你自己掌控的运动01:04:37 出来跑步，最重要的是先「出来」01:06:43 泡泡跑、动物园跑、胶片跑，怎么有趣怎么跑！01:09:42 跑步没那么难，但科学训练才是跑得久的秘诀01:12:17 当我们穿上跑鞋、走上赛道，成为真正的自己- 本节目由耐克出品，JustPod制作发行 -- 制作团队 -策划：孙佳祺、赵依侬、Jimmy、Tiara、王童语统筹：Cora、王冰倩制作：王童语声音设计：陆佳杰、马若晨节目运营：邓逸轩

Bryan Power, Head of People at Nextdoor, joined us on The Modern People Leader. We talked about how the company is navigating its “third era” under the return of co-founder Nirav Tolia. We explored “The Founders Mentality”, embracing an owner's mindset, and Nextdoor's AI bootcamp.---- Sponsor Links:

Today on the Dr. Geo Prostate Podcast, we're joined by world-renowned oncologist Dr. Rana McKay of UC San Diego Health. With training from Harvard and Dana-Farber, Dr. McKay breaks down the evolving landscape of triplet therapy—a combination of ADT, an ARPI (androgen receptor pathway inhibitor), and chemotherapy (docetaxel)—and how it's changing survival outcomes for men with advanced prostate cancer.In this enlightening and practical episode, Dr. Geo and Dr. McKay discuss:What triplet therapy is and how it compares to doublet therapyThe latest clinical trials and the importance of timing treatmentHow to personalize care for high- and low-volume metastatic prostate cancerWhen to escalate treatment—and when quality of life may outweigh aggressive therapyThe role of genomic tools like the Decipher score in decision-makingSide effect profiles, cold therapy, fasting, and integrative strategiesWhy communication and patient values should drive treatment decisionsIf you or a loved one is facing a diagnosis of advanced prostate cancer, this episode offers invaluable clarity and hope.

Jessica Zwaan, COO at Talentful and author of Built for People,  joined us on The Modern People Leader.We talked about “human ops” versus “people ops”, the sprint planning process for her people team, and how nobody gets people ops as a product 100% right (and that's ok).---- Sponsor Links:

Send us a textAward-winning excellence doesn't happen by accident. After receiving the news that Habitation Investigation had earned the prestigious "Best in the Midwest" award for the third consecutive year, we decided to peel back the curtain and share what makes our home inspection company different from the competition.This episode explores the factors that contribute to our continued success, from our customer-first approach to our ethical business practices. With over 1,700 Google reviews and a stellar 4.9-star rating, we've built a reputation on clear communication, thorough inspections, and reports that set the standard for the industry. Our team shares how we've grown from our humble beginnings in 2002 to become one of Ohio's premier inspection companies, expanding our services based directly on client requests rather than arbitrary business decisions.We tackle a particularly important topic for homeowners: privacy protection. Unlike many inspection companies that generate revenue by selling client information to third parties, we maintain strict privacy standards. Our single partnership with ADT is completely optional for clients and directs benefits to charities rather than our bottom line. We also discuss the value of maintenance inspections every 3-5 years and regular radon testing—services that can save homeowners thousands by catching small issues before they become expensive problems.What truly sets an inspection company apart isn't fancy technology or marketing gimmicks—it's having inspectors who genuinely care about their clients and communicate clearly without fear-mongering. Whether you're a homeowner, real estate professional, or aspiring entrepreneur, this episode offers valuable insights into building a service business based on integrity, customer care, and consistent quality. Ready to learn what makes a home inspection company worthy of multiple industry awards? Listen now and discover how excellence becomes a habit.Support the showTo learn more about Habitation Investigation, the Three-time Winner of the Best Home Inspection Company in the Midwest Plus the Winner of Consumer Choice Award for Columbus Ohio visit Home Inspection Columbus Ohio - Habitation Investigation (homeinspectionsinohio.com) NBC4 news segments: The importance of home inspections, and what to look for | NBC4 WCMH-TV Advice from experts: Don't skip the home inspection | NBC4 WCMH-TV OSU student's mysterious symptoms end up tied to apartment's air quality | NBC4 WCMH-TV How to save money by winterizing your home | NBC4 WCMH-TV Continuing Education for Ohio Agents Scheduled classes Continuing Education for Ohio Agents Course lis...

Reggie Marable is the Head of Global Sales at Sierra, a conversational AI platform for businesses. Sierra enables companies like ADT, Sonos, SiriusXM, and WeightWatchers to build AI agents that transform customer experiences. The company has rapidly become a hypergrowth leader in Silicon Valley, recently securing a funding round that values it at $4.5 billion. Before joining Sierra, Reggie was the Head of Sales in North America at Slack and the Area Vice President of Enterprise Sales at Salesforce.  In Today's Episode We Discuss:  02:50 “What I Learned from Failing Early as a CRO” 06:06 The Most Effective Sales Strategy and the BS Sales Methodology 06:55 How to Build Sales Processes from Scratch 12:28 When and How to do Verticalised Sales Teams 14:15 How to Become World Class as Sales Prospecting and Outbound 17:21 How to Use Proof of Concepts to Win Enterprise Deals 22:04 Enterprise vs. Self-Serve: Both or One and How 30:09 Building a Sales Team from Scratch 37:39 Structuring the Hiring Process 41:14 How Founders F*** Up Hiring in Sales 46:25 Handling Salary and Title Expectations 51:36 How to Run Effective Deal Cycles 57:06:07 How to do Onboarding for New Sales Hires 59:07:48 How to do Post Mortems in Sales Processes 01:04:24 Negotiating Enterprise Deals 01:08:04 Quick Fire Round: Sales Tactics and Strategies  

Taylor Bradley, VP of Talent Strategy and Success at Turing, joined us on The Modern People Leader.We talked about why every HR team needs to create an AI “prompt pantry”, how Turing “AI'd” their way out of onboarding 800 employees in five days, and how to build AI workflows for HR.---- Sponsor Links:

On this week's show: Yale has a new lock with easy integration with ADT systems, Google kills 1st and 2nd gen Nest devices, Aqara releases a few new products, Wiz shows off a new HDMI TV light, light bulb cameras are a thing, Roku has new cameras, Eve joins Home Assistant, letters from the mailbag, a pick of the week, project updates, and so much more!

Dr. Rohan Garje shares the updated recommendations for the ASCO guideline on systemic therapy for patients with metastatic castration-resistant prostate cancer. He discusses the systemic therapy options for patients based on prior therapy received in the castration-sensitive and non-metastatic castration-resistant settings. He emphasizes personalizing treatment choices for each individual, considering patient-specific symptoms and signs, treatment-related toxicities, potential drug interactions, cost, and access. He also reviews recommendations on response assessment. The conversation wraps up with a discussion of potential future updates to this guideline, as the guideline transitions into a “living guideline” on mCRPC. Read the full guideline update, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update”. Transcript This guideline, clinical tools, and resources are available at www.asco.org/genitourinary-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology.      Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Rohan Garje from Miami Cancer Institute Baptist Health South Florida, lead author on, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update.” Thank you for being here today, Dr. Garje. Dr. Rohan Garje: Absolutely. Thank you so much for having me, Brittany. Brittany Harvey: And then before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Garje, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to start on the content of this guideline, first, could you provide us an overview of the purpose of this guideline update? Dr. Rohan Garje: Sure. So ASCO has guidelines for prostate cancer and the specific guideline which we have updated for metastatic castrate-resistant prostate cancer was originally published in 2014. It's almost a decade. It's been a long time due for an update. Over the last decade, we have seen a lot of advances in the treatment of prostate cancer, specifically with regards to genomic testing, newer imaging modalities, and also the treatment landscape. Now we have newer options based on genomic targets such as PARP inhibitors, we have radiopharmaceuticals, a newer variant of chemotherapy, and also some specific indications for immunotherapy which were not addressed previously. Because all these advances have been new, it was really important for us to make an update. In 2022, we did make a rapid update with lutetium-177, but these additional changes which we have seen made it an appropriate time frame for us to proceed with a newer guideline. Brittany Harvey: Absolutely. It's great to hear about all these advances in the field to provide new options. So I'd like to next review the key recommendations from this guideline. So let's start with the overarching principles of practice that the panel outlined. What are these key principles? Dr. Rohan Garje: As a group, all the panel members came up with some ground rules: What are necessary for all our patients who are being treated for metastatic CRPC? First, the founding aspect was a definition for what is metastatic CRPC. So we defined metastatic CRPC as castrate level of testosterone with evidence of either new or progressive metastatic disease on radiological assessments or patients who have two consecutive rising PSAs in the setting of existing metastatic disease. We also emphasized on the need for germline and somatic testing for patients with metastatic prostate cancer at an earliest available opportunity because it is critical to select appropriate treatment and also right treatment for patients at the right time. And we actually have a concurrent guideline which addresses what genes to be tested and the timing. The other principles are patients should continue to receive androgen deprivation therapy or undergo surgical castration to maintain castrate level of testosterone. Now the key aspect with these guidelines is personalizing treatment choices. As you can see the evolution of treatment options for prostate cancer, the drugs that were initially developed and approved for prostate cancer were primarily in castrate-resistant settings, but now most of these drugs are being utilized in castrate-sensitive. So, when these patients develop castration resistance, the challenges are there are no appropriate particular drug-specific guidelines they meet. So, it's very important for the clinicians to be aware of what treatments have been received so far prior to castration resistance so that they can tailor the treatment to patient specific situations. In addition, prior to choosing a therapy, it is important for the physicians to consider patient specific symptoms or signs, treatment-related toxicities, potential drug interactions, cost, and also access to the drugs. There may be multiple treatment options available for the patients, but for a patient specific scenario, there may be a drug that may be more promising than the others. So, it is important to tailor the drug choices based on patients' unique circumstances. The panel also recommends to early integrate palliative and supportive care teams for symptom management and also discuss goals of care with the patient as each patient may have unique needs and it's important for physicians to address those concerns upfront in the care. The panel also suggests patients to receive RANK ligand inhibitors such as denosumab or bisphosphonates such as zoledronic acid to maintain the bone strength to prevent skeletal-related events. Finally, I would like to also emphasize this point about the lack of randomized clinical trial data for optimal sequencing of therapies for patients with metastatic CRPC. As I previously alluded, we have taken into account all ongoing clinical trials, prior published data, and came up with a format of preferred drugs based on prior treatments and, I think, by following these several clinical principles which I just mentioned, we can optimally choose and utilize best treatments for patients with metastatic CRPC. Brittany Harvey: Absolutely. These principles that you just outlined are important for optimal patient care, and then I want to touch on one of those things. You talked importantly about the treatments received so far. So in the next set of recommendations, the role of systemic therapy was stratified by the prior therapy received in the castration-sensitive and non-metastatic castration-resistant setting. So starting with what does the panel recommend for patients who are previously treated with androgen deprivation therapy alone in these previous settings and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: There are multiple treatment options based on prior treatment received. So for patients who received only ADT for their castration-sensitive disease, the panel strongly urges to get HRR testing to check for homologous recombinant repair related changes, specifically for BRCA1 and BRCA2 mutations, because we have three studies which have really shown significant clinical benefit for patients who have BRCA1 and BRCA2 mutations with drugs such as the combination of talazoparib and enzalutamide or olaparib with abiraterone or niraparib with abiraterone. Unless we test for those mutations, we'll not be able to give these agents upfront for the patients. In the HRR testing, if patients have HRR alterations but they are in genes which are non-BRCA, the guideline panel recommends to utilize talazoparib and enzalutamide based combination therapies. Now, if they don't have HRR alterations then there are multiple treatment choices available. It could either include androgen receptor pathway inhibitors such as abiraterone with prednisone. We could also consider docetaxel chemotherapy. The alternate choices for androgen receptor pathways include enzalutamide or the newer agents such as apalutamide and docetaxel. So, as you can see there are multiple options available, but the panel definitely emphasizes to test for HRR testing because this gives patients access to more precision therapies at this point. There may be various scenarios where a unique drug may be available for a specific patient situation. For example, patients who have very limited disease burden and may have one or two metastatic lesions, after a multidisciplinary discussion, targeted local therapies such as radiation or potentially surgery could also be offered. In select patients who have very indolent disease where they are castrate-resistant based on slow rising PSA, low-volume disease or asymptomatic disease can consider sipuleucel-T. And in patients who have bone-only metastatic disease, we could also consider radium-223, which is primarily now utilized for patients who have symptomatic bone disease. Brittany Harvey: Great. I appreciate you reviewing all those options and talking about how important it is to tailor treatment to the individual patient. So then the next category of patients, what is recommended for those who have been previously treated with ADT and an androgen receptor pathway inhibitor and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: So for patients who received ADT along with an androgen receptor pathway inhibitor, which we consider would be a most common cohort because most patients now in castration-sensitive setting are receiving androgen receptor pathway inhibitor. It was different in the past where five or six years back ADT alone was the most common treatment, but fortunately, with enough awareness and education, treatment choices have improved. Patients are now receiving ADT and ARPI as the most common choice of drug. Once again, at this point the panel emphasizes to consider HRR testing in there is enough data for us to suggest that patients who have alterations in the HRR pathway definitely will benefit with the PARP inhibitor. You know the multiple options, but specifically we speak about olaparib. And then if they are HRR-negative, we prefer patients receive agents such as docetaxel or if they are intolerant to docetaxel, consider cabazitaxel chemotherapy, options such as radium-223, and if they have a specific scenario such as MSI-high or mismatch repair deficiency, pembrolizumab could also be considered. The panel also discussed about the role of a second ARPI agent. For example, if patients progressed on one androgen receptor pathway inhibitor, the second androgen receptor pathway inhibitor may not be effective and the panel suggests to utilize alternate options before considering androgen receptor pathway inhibitor. There may be specific scenarios where a second ARPI may be meaningful, specifically, if alternate choices are not feasible for the concern of side effects or toxicities or lack of access, then a potential ARPI could be considered after progression on ARPI, but the panel definitely encourages to utilize alternate options first. Brittany Harvey: Great. Thank you for outlining those options as well for those patients. So then the next category, what is recommended for patients who have been previously treated with ADT and docetaxel? Dr. Rohan Garje: For patients who received ADT and docetaxel and were never treated with androgen receptor pathway inhibitors, the panel again emphasizes on HRR testing. If they have BRCA1 and 2 mutations, the combination therapies of talazoparib with enzalutamide, olaparib with abiraterone, or niraparib with abiraterone are all good choices. If they don't have BRCA mutations but they have other HRR mutations, the panel suggests to potentially utilize talazoparib with enzalutamide. And if they do not have any HRR alterations, the options could include androgen receptor pathway inhibitors such as abiraterone or enzalutamide. I want to emphasize that these are preferred options, but not the only options. As you can see, there are multiple options available for a particular clinical situation - so the ability of the physicians to access particular combinations, the familiarity of those drugs or the patient's unique situation where they have other medications which can potentially interact with a choice of agents. So I think based on access, based on cost and patients' concurrent illness with potential drug interactions can make one particular combination of therapy better over the other options. Brittany Harvey: Absolutely. That's key to keep in mind that access, contraindications, and cost all play a role here. So then the next set of recommendations. What are the key recommendations for patients who have previously been treated with ADT, an androgen receptor pathway inhibitor, and docetaxel who now have mCRPC? Dr. Rohan Garje: Yes. In this group, the options remain, again, broad. We utilize PSMA imaging here specifically and if they are positive on PSMA imaging, lutetium-177 is a good option. If they do not have PSMA-positive disease on PSMA imaging but if they have HRR alterations, olaparib could be utilized. And if they are negative on PSA imaging, they don't have HRR alterations, then alternate options could include cabazitaxel, radium-223. And if they have MSI-high or deficiency in mismatch repair, pembrolizumab could be utilized in this setting. Brittany Harvey: Thank you for outlining those options as well. So then next the panel addressed treatment options for de novo or treatment emergent small cell neuroendocrine carcinoma of the prostate. What are those key recommendations? Dr. Rohan Garje: Yes. This is a very high unmet need group because there are limited clinical trials, especially prospective clinical trials addressing treatment options for this group. Most of our current guidelines are always an extrapolation from lung small cell cancer based guidelines, but the panel recommends to utilize cisplatin or carboplatin along with etoposide as a preferred choice for this group. Also, an alternate option of carboplatin along with cabazitaxel could be considered for this cohort. The panel also encourages participation in clinical trials. There are numerous trials ongoing now in smaller phase studies and I think it's important for patients to consider these trials as well, because this will give them access to newer agents with potential biological targets. In addition to these agents in specific scenarios or potentially case by case basis, because we don't have prospective data, so we have made it as a select case by case basis to consider adding immunotherapy along with platinum-based chemotherapy followed by maintenance immunotherapy, which is currently a standard of care in small cell lung cancer. But the data is so limited in prostate cancer, so the panel suggested that it has to be a case by case basis only. The alternate options also include lurbinectedin, topotecan, tarlatamab upon progression on platinum-based chemotherapy. Brittany Harvey: Yes. It's important to have these recommendations in these unique situations where there is really a lack of data. So then the final set of recommendations I'd like to cover, what does the panel recommend for how clinicians should assess for response while patients are on systemic therapy and what scans are recommended for this response assessment? Dr. Rohan Garje: Yes. Again, this is another strong emphasis of the panel for global assessment of the patients. Traditionally, patients and physicians per se are heavily reliant on PSA as an accurate marker for response. This is in fact true in earlier phases of prostate cancer either in castrate-sensitive setting or localized prostate cancer setting. But as patients evolve into castrate-resistant, we don't want to heavily rely on PSA alone as a marker of response. The panel suggests to incorporate clinical response, radiological response, and also include PSA as a component, but not just rely primarily on PSA. So the panel also suggests that patients should get a bone scan and a CT scan every three to six months while on treatment to assess for appropriate response or for progression. And now one key important aspect, we are all aware about the evolving role of PSMA-based imaging with several of these new agents that are currently available. We do acknowledge these scans definitely have an important role in the care for patients with metastatic prostate cancer. Currently, the utility is primarily to select patients for lutetium-based therapy and also in situations where the traditional scans such as technitium 99 bone scan or CT scan are equivocal, then a PSMA-based imaging can be helpful. Now we are also aware that there are newer studies coming up, prospective data coming up for the role of PSMA-based imaging for response assessment. We are hoping to update the guidelines if we get access to newer data, but currently we have not recommended the utility of PSMA-based imaging for response assessments. Brittany Harvey: Understood. And I appreciate you describing where there is data here and where there's a lack of data to currently recommend. And we'll look forward to future updates of this guideline. Coming back to – at the start you mentioned how much has changed since the last guideline update. So Dr. Garje, in your view, what is the importance of this update and how will it impact both clinicians and patients with metastatic castration-resistant prostate cancer? Dr. Rohan Garje: The updated guidelines are designed to have a significant impact on clinical practice and also patient outcomes by providing clinicians with a comprehensive evidence-based framework for managing patients with metastatic CRPC. And also, by using these guidelines can make informed decisions, can select therapies tailored to patients' unique genomic status, clinical situation, where they are in the course of the cancer based on what they received previously. Also utilizing these guidelines, we can potentially improve patient outcomes, improve survival, and importantly have efficient use of healthcare resources. Brittany Harvey: Absolutely. We're always looking for ways to improve patient outcomes and survival. I want to wrap us up by talking a little bit about the outstanding questions in this field. So earlier you had mentioned about prospective data to come about PSMA PET scans, but what other outstanding questions are there for patients with metastatic castration-resistant prostate cancer? And what evidence is the panel looking forward to for future updates? Dr. Rohan Garje: We do have now rapidly evolving data specifically about the utility of the radiopharmaceutical lutetium-177 prior to chemotherapy. We are hoping that with newer data we can make some changes to the guideline based on that. We are also looking at newer drugs that are coming up in the pipeline, for example, androgen receptor degraders. We are looking at data that might potentially help based on bispecific T-cell engagers and newer radiopharmaceuticals. So I think in the next few years, we will definitely update all the guidelines again. But this time we are trying to do it more proactively. We are following a newer model. We are calling it as ‘living guidelines' where we are actually utilizing week by week updates where we look at the literature and see if there is any potential practice impacting change or publication that comes up. And we are trying to incorporate those changes as soon as they are available. That way patients and practicing physicians can get the latest information available through the guidelines as well. Brittany Harvey: That's great to hear. Yes, we'll await this data that you mentioned to continuously update this guideline and continue to improve patient outcomes for the future. So Dr. Garje, I want to thank you so much for your time to update this guideline. It was certainly a large amount of recommendations, and thank you for your time today, too. Dr. Rohan Garje: Thank you so much for having me here. And it's always nice talking to you. Brittany Harvey: And finally, thank you to our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/genitourinary-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Live from AUA2025: Advances in ADT Program CME Available: https://auau.auanet.org/content/LiveFromAUA2025#group-tabs-node-course-default1 At the conclusion of this CME activity, participants will be able to: 1. Employ the latest AUA and NCCN guidelines (Version 1.2025) related to Androgen Deprivation Therapy (ADT) into practice 2. Evaluate clinical outcomes, efficacy, and safety profiles of different types of ADT including oral and parenteral LHRH agonists and GnRH receptor antagonists in different treatment settings. 3. Compare testosterone recovery, treatment efficacy, safety profiles, and patient preferences between different modalities of ADT. 4. Recognize common side effects associated with different types of ADT and its combination therapies as well as strategies to mitigate these adverse effects to improve patient outcomes. 5. Implement a multi-disciplinary approach in managing advanced prostate cancer with ADT. 6. Evaluate the future directions and ongoing research that may impact the use of ADT in clinical practice.

Tämä jakso sai sytykkeensä muutamasta viestinvaihdosta, jossa pohdin vieraiden kanssa miten voisimme tuoda näkökulmia ja ratkaisuehdotuksia suomalaisiakin vaivaaviin suorituskulttuuriin sekä burnout-ahdistusepidemiaan sekä pohtia mistä syntyy yksilön inhimillinen huippusuorituskyky. Jaksossa käydään läpi mm. mitä suorittamisen tunne ylipäätään on, mistä se syntyy ja mitä sille voi tehdä? Onko kaikki totaalisen rikki, miksi kaikki tuntuu uupuvan ja mitä ongelmien selättämiselle voi tehdä? Onko tämä pelkkä somekeskustelun illuusio vai mitä ihmisten arjessa oikeasti tapahtuu? Mitä kokonaiskuormitukselle voi tehdä yksilö itse ja myös työnantaja? Mitä on inhimillinen tehokkuus ja mistä se syntyy? Miten elintavat ja fyysinen kunto vaikuttaa siihen, että miten työtä, arkea ja perhe-elämää jaksaa hyvällä vireellä? Millaisia erilaisia haasteita ja mahdollisuuksia on työelämässä eri ikäluokilla? Miten elää hyvää elämää ja suoriutua arjen vastuista hyvin jos tarkkaavaisuuden kanssa on haasteita (ADT, ADHD, jne.)? Näitä ja muita aihepiirin kysymyksiä pohdin yhdessä psyykkisen ja fyysisen suorituskyvyn valmentaja Heikki Huovisen ja psykologi ja traumapsykoterapeutti Hanna Markukselan kanssa.LinkitOptimal Performance- Hyvinvointiluennot ja verkkovalmennukset: https://www.optimalperformance.fi- Kuntosali ja valmennuskeskus, Helsinki: https://www.opcenter.fiHeikki Huovinen ja Hanna Markuksela- HPA IG: https://www.instagram.com/higherperformanceacademy/- Suorituskyvyn ytimessä -podcast: https://open.spotify.com/show/7pN53RJdSsAnnfCY08G9MI?si=db8f73d99bc24534- Vireysvalmentaja-koulutus: https://hannamarkuksela.mykajabi.com/koulutusilmoittautuminen-vireysvalmentaja- Verkkosivu: https://www.higherperformanceacademy.com/- Hanna IG: https://www.instagram.com/hannamarkuksela/- Heikki IG: https://www.instagram.com/heikkihuovinencoach/

Check out this week's QuadCast as we highlight the predictive abilities of AI for ADT duration in prostate cancer, how consolidative chemoRT benefits patients with unresectable gallbladder cancer, the benefits of immunotherapy in clear cell GYN cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom

Molly Sands, Head of the Teamwork Lab at Atlassian, joined us on The Modern People Leader.We talked about Atlassian's latest research on the three things the best teams do differently, the power of unleashing collective knowledge, and why distributed teams have a headstart on AI adoption.---- 

Really Interesting Women The Podcast Ep. 147 Meryl TankardMeryl Tankard is one of Australia's most distinguished and innovative figures in contemporary dance and choreography. Her talent was recognised very early - and even at that early stage she knew the 'old school' teaching techniques were, at times, abhorrent. But despite this, her talent flourished. To the point where she auditioned and earned a place in the Australian Ballet. But in her mind she wanted more. She joined the prestigious Pina Bausch Tanztheater Wuppertal in Germany, where she became a principal artist and developed her distinctive artistic voice.Upon returning to Australia in the early 1990s, she served as Artistic Director of the Australian Dance Theatre (ADT) in Adelaide, transforming it into a globally recognised company. And that led inexplicably to a controversial move by the ADT that we talk about. But it's her bold, theatrical productions that merged dance with other art forms that have impressed audiences the world over. Her choreographic style is characterised by emotional intensity, physical dynamism, and a unique blend of classical technique with contemporary expression.She has created works for opera, film, and large-scale events, including contributions to the Sydney 2000 Olympic Games ceremonies.And as if for good measure she's a qualified and exceptional film maker. To this day Meryl Tankard remains an influential force in Australian performing arts, celebrated for her passionate commitment to artistic innovation and her ability to create deeply moving dance experiences.It was a great conversation with an enduring, warm, immensely talented artist. You can see the clips I was referring to in our conversation at:https://meryltankard.com/workHead to the link in my bio to hear our conversation. Visit instagram @reallyinterestingwomen for further interviews and posts of interesting women in history. Follow the link to leave a review....and tell your friendshttps://podcasts.apple.com/au/podcast/really-interesting-women/id1526764849

Marine Corps Veteran Edgar Rodriguez joins Joe on this episode of Veteran On the Move. Edgar shares his journey transitioning into the communication industry, highlighting his experience in sales with ADT and the valuable lessons learned through Wolf Management's Capstone program. They discuss the power of connecting with like-minded individuals, building strong relationships, and the role of executive coaching in establishing a solid team based on the five pillars of business. Ultimately, Edgar emphasizes the significance of discovering one's passion and forging a fulfilling path. Episode Resources:  Master the Network Edgar's LinkedIn   About Our Sponsors Navy Federal Credit Union   Navy Federal Credit Union has made it their mission to help people in the military community. Navy Federal Credit Union is open to all branches of the military, Veterans and their families. They have lots of flexible savings and investing options to help their members reach their financial goals. Don't miss out. The sooner you start building your finances with savings and investing options, the better off they could be in the long run.  At Navy Federal, our members are the mission.        Join the conversation on Facebook! Check out Veteran on the Move on Facebook to connect with our guests and other listeners. A place where you can network with other like-minded veterans who are transitioning to entrepreneurship and get updates on people, programs and resources to help you in YOUR transition to entrepreneurship.   Want to be our next guest? Send us an email at interview@veteranonthemove.com.  Did you love this episode? Leave us a 5-star rating and review!  Download Joe Crane's Top 7 Paths to Freedom or get it on your mobile device. Text VETERAN to 38470. Veteran On the Move podcast has published 500 episodes. Our listeners have the opportunity to hear in-depth interviews conducted by host Joe Crane. The podcast features people, programs, and resources to assist veterans in their transition to entrepreneurship.  As a result, Veteran On the Move has over 7,000,000 verified downloads through Stitcher Radio, SoundCloud, iTunes and RSS Feed Syndication making it one of the most popular Military Entrepreneur Shows on the Internet Today.

Pat Wadors, CHRO at Intuitive, joined us on The Modern People Leader. We talked about how to find and amplify the golden nuggets of your culture, the three layers of a great employee experience, why you need to “touch the elephant”, and what kids' stories can teach us about leadership.---- 

In this episode of the Dr. Geo Prostate Podcast, we welcome Dr. Jonathan Lischalk, Director of Genitourinary Cancers at MedStar Georgetown University Hospital and former Medical Director at NYU's NYCyberKnife Center. Dr. Lischalk breaks down the evolution of radiation oncology and how cutting-edge imaging and targeted SBRT (Stereotactic Body Radiation Therapy) are reshaping prostate cancer treatment.We explore how imaging advances like MRI and PSMA PET scans are enabling unprecedented precision, the future of genetic-based personalization in prostate cancer therapy, and why fewer, more focused radiation sessions might soon become the new standard. From understanding the biology of radiation dosing to upcoming trials eliminating ADT in select patients, this is a must-listen for anyone looking to stay informed on the forefront of cancer care.

JCO PO author Dr. Timothy Showalter at Artera and University of Virginia shares insights into his JCO PO article, “Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer” . Host Dr. Rafeh Naqash and Dr. Showalter discuss how multimodal AI as a prognostic marker in nonmetastatic castration-resistant prostate cancer may serve as a predictive biomarker with high-risk patients deriving the greatest benefit from treatment with apalutamide. TRANSCRIPT  Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where we'll bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast Editor for JCO Precision Oncology and assistant professor at the OU Health Stephenson Cancer Center at the University of Oklahoma. Today, we are excited to be joined by Dr. Timothy Showalter, Chief Medical Officer at Artera and professor of Radiation Oncology at the University of Virginia and author of the JCO Precision Oncology article entitled, “Digital Pathology Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase 3 Trial in Men with Non-Metastatic Castration Resistant Prostate Cancer.” At the time of this recording, our guest's disclosures will be linked in the transcript. Dr. Showalter, it's a pleasure to have you here today. Dr. Timothy Showalter: It's a pleasure to be here. Thanks for having me. Dr. Rafeh Naqash: I think this is going to be a very interesting discussion, not just from a biomarker perspective, but also in terms of how technologies have evolved and how we are trying to stratify patients, trying to escalate or deescalate treatments based on biomarkers. And this article is a good example of that. One of the things I do want to highlight as part of this article is that Dr. Felix Feng is the first author for this article. Unfortunately, Dr. Felix Feng passed away in December of 2024. He was a luminary in this field of prostate cancer research. He was also the Chair of the NRG GU Committee as well as Board of Directors for RTOG Foundation and has mentored a lot of individuals from what I have heard. I didn't know Dr. Feng but heard a lot about him from my GU colleagues. It's a huge loss for the community, but it was an interesting surprise for me when I saw his name on this article as I was reviewing it. Could you briefly talk about Dr. Feng for a minute and how you knew him and how he's been an asset to the field? Dr. Timothy Showalter: Yeah. I'm always happy to talk about Felix whenever there's an opportunity. You know, I was fortunate to know Felix Feng for about 20 years as we met during our residency programs through a career development workshop that we both attended and stayed close ever since. And you know, he's someone who made an impact on hundreds of lives of cancer researchers and other radiation oncologists and physicians in addition to the cancer patients he helped, either through direct clinical care or through his innovation. For this project in particular, I first became involved soon after Felix had co-founded Artera, which is, you know the company that developed this. And because Felix was such a prolific researcher, he was actually involved in this and this research project from all different angles, both from the multimodal digital pathology tool to the trial itself and being part of moving the field forward in that way. It's really great to be able to sort of celebrate a great example of Felix's legacy, which is team science, and really moving the field forward in terms of translational projects based on clinical trials. So, it's a great opportunity to highlight some of his work and I'm really happy to talk about it with you. Dr. Rafeh Naqash: Thanks, Tim. Definitely a huge loss for the scientific community. And I did see a while back that there was an international symposium organized, showcasing his work for him to talk about his journey last year where more than 200, 250 people from around the globe actually attended that. That speaks volumes to the kind of impact he's had as an individual and impact he's had on the scientific side of things as well. Dr. Timothy Showalter: Yes. And we just had the second annual Feng Symposium the day before ASCO GU this year with, again, a great turnout and some great science highlighted, as well as a real focus on mentorship and team science and collaboration. Dr. Rafeh Naqash: Thank you so much for telling us all about that. Now going to what you guys published in JCO Precision Oncology, which is this article on using a biomarker approach to stratify non-metastatic prostate cancer using this artificial intelligence based H&E score. Could you tell us the background for what started off this project? And I see there is a clinical trial data set that you guys have used, but there's probably some background to how this score or how this technology came into being. So, could you superficially give us an idea of how that started? Dr. Timothy Showalter: Sure. So, the multimodal AI score was first published in a peer reviewed journal back in 2022 and the test was originally developed through a collaboration with the Radiation Therapy Oncology Group or Energy Oncology Prostate Cancer Research Team. The original publication describes development and validation of a risk stratification tool designed to predict distant metastasis and prostate cancer specific mortality for men with localized prostate cancer. And the first validation was in men who were treated with definitive radiation therapy. There have been subsequent publications in that context and there's a set of algorithms that have been validated in localized prostate cancer and there's a test that's listed on NCCN guidelines based on that technology. The genesis for this paper was really looking at extending that risk stratification tool that was developed in localized prostate cancer to see if it could one, validate in a non-metastatic castrate refractory prostate cancer population for patients enrolled on the SPARTAN trial. And two, whether there was a potential role for the test output in terms of predicting benefit from apalutamide for patients with non-metastatic prostate cancer. For patients who are enrolled on the SPARTAN study, almost 40% of them had H&E stain biopsy slide material available and were eligible to be included in this study. Dr. Rafeh Naqash: Going a step back to how prostate cancer, perhaps on the diagnostic side using the pathology images is different as you guys have Gleason scoring, which to the best of my knowledge is not necessarily something that most other tumor types use. Maybe Ki-67 is somewhat of a comparison in some of the neuroendocrine cancers where high Ki-67 correlates with aggressive biology for prognosis. And similarly high Gleason scores, as we know for some of the trainees, correlates with poor prognosis. So, was the idea behind this based on trying to stratify or sub-stratify Gleason scoring further, where you may not necessarily know what to do with the intermediate high Gleason score individual tumor tissues? Dr. Timothy Showalter: Well, yeah. I mean, Gleason score is a really powerful risk stratification tool. As you know, our clinical risk groupings are really anchored to Gleason scores as an important driver for that. And while that's a powerful tool, I think, you know, some of the original recognition for applying computer vision AI into this context is that there are likely many other features located in the morphology that can be used to build a prognostic model. Going back to the genesis of the discovery project for the multimodal AI model, I think Felix Feng would have described it as doing with digital pathology and computer vision AI what can otherwise be done with gene expression testing. You know, he would have approached it from a genomic perspective. That's what the idea was. So, it's along the line of what you're saying, which is to think about assigning a stronger Gleason score. But I think really more broadly, the motivation was to come up with an advanced complementary risk stratification tool that can be used in conjunction with clinical risk factors to help make better therapy recommendations potentially. So that was the motivation behind it. Dr. Rafeh Naqash: Sure. And one of the, I think, other important teaching points we try to think about, trainees of course, who are listening to this podcast, is trying to differentiate between prognostic and predictive scores. So, highlighting the results that you guys show in relation to the MMAI score, the digital pathology score, and outcomes as far as survival as well as outcomes in general, could you try to help the listeners understand the difference between the prognostic aspect of this test and the predictive aspect of this test? Dr. Timothy Showalter: So let me recap for the listeners what we found in the study and how it kind of fits into the prognostic and the predictive insights. So, one, you know, as I mentioned before, this is ultimately a model that was developed and validated for localized prostate cancer for risk stratification. So, first, the team looked at whether that same tool developed in localized prostate cancer serves as a prognostic tool in non-metastatic castrate-refractory prostate cancer. So, we applied the tool as it was previously developed and identified that about 2/3 of patients on the SPARTAN trial that had specimens available for analysis qualified as high risk and 1/3 of patients as either intermediate or low risk, which we called in the paper ‘non-high risk'. And we're able to show that the multimodal AI score, which ranges from 0 to 1, and risk group, was associated with metastasis free survival time to second progression or PFS 2 and overall survival. And so that shows that it performs as a prognostic tool in this setting. And this paper was the first validation of this tool in non-metastatic castrate-refractory prostate cancer. So, what that means to trainees is basically it helps you understand how aggressive that cancer is or better stratify the risk of progression over time. So that's the prognostic performance. Dr. Rafeh Naqash: Thank you for trying to explain that. It's always useful to get an example and understand the difference between prognostic and predictive. Now again, going back to the technology, which obviously is way more complicated than the four letter word MMAI, I per se haven't necessarily done research in this space, but I've collaborated with some individuals who've done digital pathology assessments, and one of the projects we worked on was TIL estimation and immune checkpoint related adverse events using some correlation and something that one of my collaborators had sent to me when we were working on this project as part of this H&E slide digitalization, you need color deconvolution, you need segmentation cell profiling. Superficially, is that something that was done as part of development of this MMAI score as well? Dr. Timothy Showalter You need a ground truth, right? So, you need to train your model to predict whatever the outcome is. You know, if you're designing an AI algorithm for Ki-67 or something I think you mentioned before, you would need to have a set of Ki-67 scores and train your models to create those scores. In this case, the clinical annotation for how we develop the multimodal AI algorithm is the clinical endpoints. So going back to how this tool was developed, the computer vision AI model is interpreting a set of features on the scan and what it's trying to do is identify high risk features and make a map that would ultimately predict clinical outcomes. So, it's a little bit different than the many digital pathology algorithms where the AI is being trained to predict a particular morphological finding. In this case, the ground truth that the model is trained to predict is the clinical outcome. Dr. Rafeh Naqash: Sure. And from what you explained earlier, obviously, tumors that had a high MMAI score were the ones that were benefiting the most from the ADT plus the applausive. Is this specific for this androgen receptor inhibitor or is it interchangeable with other inhibitors that are currently approved? Dr. Timothy Showalter: That's a great question and we don't know yet. So, as you're alluding to, we did find that the MMAI risk score was predictive for benefit from apalutamide and so it met the statistical definition of having a significant interaction p value so we can call it a predictive performance. And so far, we've only looked in this population for apalutamide. I think you're raising a really interesting point, which is the next question is, is this generalizable to other androgen receptor inhibitors? There will be future research looking at that, but I think it's too early to say. Just for summary, I think I mentioned before, there are about 40% of patients enrolled on the SPARTAN study had specimens available for inclusion in this analysis. So, the SPARTAN study did show in the entire clinical trial set that patients with non-metastatic castrate-refractory prostate cancer benefited from apalutamide. The current study did show that there seems to be a larger magnitude of benefit for those patients who are multimodal AI high risk scores. And I think that's very interesting research and suggests that there's some interaction there. But I certainly would want to emphasize that we have not shown that patients with intermediate or low risk don't benefit from apalutamide. I think we can say that the original study showed that that trial showed a benefit and that we've got this interesting story with multimodal AI as well. Dr. Rafeh Naqash: Sure. And I think from a similar comparison, ctDNA where ctDNA shows prognostic aspects, I treat people with lung cancer especially, and if you're ctDNA positive at a 3 to 4-month period, likely chances of you having a shorter disease-free interval is higher. Same thing I think for colorectal cancers. And now there are studies that are using ctDNA as an integral biomarker to stratify patients positive/negative and then decide on escalation/de-escalation of treatment. So, using a similar approach, is there something that is being done in the context of the H&E based stratification to de-intensify or intensify treatments based on this approach? Dr. Timothy Showalter: You're hitting right on the point in the most promising direction. You know, as we pointed out in the manuscript, one of the most exciting areas as a next step for this is to use a tool like this for stratification for prospective trials. The multimodal AI test is not being used currently in clinical trials of non-metastatic castrate-refractory prostate cancer, which is a disease setting for this paper. There are other trials that are in development or currently accruing where multimodal AI stratification approach is being taken, where you see among the high-risk scores, at least in the postoperative setting for a clinical trial that's open right now, high risk score patients are being randomized to basically a treatment intensification question. And then the multimodal AI low risk patients are being randomized to a de-intensification experimental arm where less androgen deprivation therapy is being given. So, I think it's a really promising area to see, and I think what has been shown is that this tool has been validated really across the disease continuum. And so, I think there are opportunities to do that in multiple clinical scenarios. Dr. Rafeh Naqash: Then moving on to the technological advancements, very fascinating how we've kind of evolved over the last 10 years perhaps, from DNA based biomarkers to RNA expression and now H&E. And when you look at cost savings, if you were to think of H&E as a simpler, easier methodology, perhaps, with the limitations that centers need to digitalize their slides, probably will have more cost savings. But in your experience, as you've tried to navigate this H&E aspect of trying to either develop the model or validate the model, what are some of the logistics that you've experienced can be a challenge? As we evolve in this biomarker space, how can centers try to tackle those challenges early on in terms of digitalizing data, whether it's simple data or slides for that matter? Dr. Timothy Showalter: I think there's two main areas to cover. One, I think that the push towards digitalization is going to be, I think, really driven by increasing availability and access to augmentative technologies like this multimodal AI technology where it's really adding some sort of a clinical insight beyond what is going to be generated through routine human diagnostic pathology. I think that when you can get these sorts of algorithms for patient care and have them so readily accessible with a fast turnaround time, I think that's really going to drive the field forward. Right now, in the United States, the latest data I've seen is that less than 10% of pathology labs have gone digital. So, we're still at an early stage in that. I hope that this test and similar ones are part of that push to go more digital. The other, I think, more interesting challenge that's a technical challenge but isn't about necessarily how you collect the data, but it certainly creates data volume challenges, is how do you deal with image robustness and sort of translating these tools into routine real-world settings. And as you can imagine, there's a lot of variation for staining protocols, intensity scanner variations, all these things that can affect the reliability of your test. And at least for this research group that I'm a part of that has developed this multimodal AI tool can tell you that the development is sophisticated, but very data and energy intensive in terms of how to deal with making a tool that can be consistent across a whole range of image parameters. And so that presents its own challenges for dealing with a large amount of compute time and AI cycles to make robust algorithms like that. And practically speaking, I think moving into other diseases and making this widely available, the size of data required and the amount of cloud compute time will be a real challenge. Dr. Rafeh Naqash: Thank you for summarizing. I can say that definitely, you know, this is maybe a small step in prostate cancer biomarker research, but perhaps a big step in the overall landscape of biomarker research in general. So definitely very interesting. Now, moving on to the next part of the discussion is more about you as a researcher, as an individual, your career path, if you can summarize that for us. And more interestingly, this intersection between being part of industry as well as academia for perhaps some of the listeners, trainees who might be thinking about what path they want to choose. Dr. Timothy Showalter: Sure. So, as you may know, I'm a professor at the University of Virginia and I climbed the academic ladder and had a full research grant program and thought I'd be in academia forever. And my story is that along the way, I kind of by accident ended up founding a medical device company that was called Advaray and that was related to NCI SBIR funding. And I found myself as a company founder and ultimately in that process, I started to learn about the opportunity to make an impact by being an innovator within the industry space. And that was really the starting point for me. About four years ago, soon after Felix Feng co-founded Artera, he called me and told me that he needed me to join the company. For those who were lucky to know Felix well, at that very moment, it was inevitable that I was going to join Artera and be a part of this. He was just so persuasive. So, I will say, you know, from my experience of being sort of in between the academic and industry area, it's been a really great opportunity for me to enter a space where there's another way of making an impact within cancer care. I've gotten to work with top notch collaborators, work on great science, and be part of a team that's growing a company that can make technology like this available. Dr. Rafeh Naqash: Thank you so much, Tim, for sharing some of those thoughts and insights. We really appreciate you discussing this very interesting work with us and also appreciate you submitting this to JCO Precision Oncology and hopefully we'll see more of this as this space evolves and maybe perhaps bigger more better validation studies in the context of this test. Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

How powerful is exercise in the fight against advanced prostate cancer? Dr. Geo speaks with world-renowned exercise oncology expert Dr. Rob Newton from Australia, whose groundbreaking research has shaped how clinicians approach fitness and cancer care. From bone metastasis to androgen deprivation therapy (ADT), Dr. Newton explains how the right exercise, at the right dose, can not only improve quality of life but potentially extend it.Together, they explore the science, practical guidelines, and inspiring stories behind using movement as medicine—even for men with metastatic, castration-resistant disease.Key TakeawaysExercise is medicine for men with prostate cancer—including advanced and metastatic cases.Resistance training helps preserve or build muscle during androgen deprivation therapy (ADT), reducing side effects like fatigue, bone loss, and metabolic issues.Even with bone metastases, exercise can be done safely with modified strength programs—no increase in fractures observed in studies.Muscle strength and fitness are strongly linked to lower cancer-related and all-cause mortality.Myokines released from working muscles have direct anti-cancer effects and support immune function.Focus on large muscle groups (legs, back, chest) using moderate to heavy weights—6 to 15 reps per set.Tailor workouts to the individual: more strength training for muscle loss, more cardio for heart/metabolic risk.Periodized, varied routines improve outcomes and help patients tolerate treatments like chemo better._________________________ Introducing The Dr. Geo Prostate Podcast Exclusive MembershipWe'll continue bringing you powerful weekly episodes to support your prostate health journey. But if you're ready to dive deeper, the Exclusive Membership gives you more: curated transcripts, detailed show notes, expert resources, and member-only perks—all designed to help you live better with age. Join HERE [https://drgeo.com/membership]_________________________ Thank you to our partnersThe ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that keep the body in a fasting state.Special Offer: As a listener, you can get the ProLon kit for just $148 using this [https://bit.ly/3TVehAx ].We'd also like to thank our partner AG1 by Athletic Greens. AG1 includes 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This blend supports your gut, immune system, energy, focus, and more—all in one daily scoop. https://bit.ly/3mA2tVV_________________________

The Ramblin Gambler, answers listeners questions in a Questions My Sons Ask segment (12:30), before revealing an additional secret ADT consideration casino use to determine how players are comped in a Core Koncepts segment (26:30). Then, TRG continues to share results from playing Beyond the Book, as taught by authors Bruce Dye and Dave Krite (40:38). Finally, in the Virtual VIP Lounge, TRG shares a free opportunity that he things every listeners should take advantage of (50:)0).

Jessica Zwaan returned to The Modern People Leader for a deep dive on how her PeopleOps as a Product philosophy came to life. We talked about the early days of the framework, writing her book, and the launch of MPL Build — a new collaboration between MPL and Jessica to bring the methodology to more teams.---- 

Today, we discuss the role of triplet therapy (ie, chemotherapy and androgen receptor signalling inhibitor and ADT) in high-volume metastatic hormone-sensitive prostate cancer and whether darolutamide is equivalent to the other androgen receptor signalling inhibitors in the castrate-sensitive space. Two good trials, and as always, some interesting discussion points.Studies discussed in the episode:ARASENSARANOTEFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

Shane Koller joined us on The Modern People Leader. We talked about adopting a product mindset in HR, how Ancestry's people team built their “product roadmap”, and why even great HR programs fall short when they're not connected.---- 

Eric Beyrich says, “this is the time of year we actually thrive” as he looks at a low-bid, high-yield strategy. He compares the ratio of value to growth in the market and says there's a “long way to go” to get back to equilibrium after tech's massive run. He expects the S&P 500 to have a bad year, but most stocks to have an up year. His picks include ADT, DOW, PFE, AMCR, and BERY.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Michele Bousquet joined us on The Modern People Leader. We talked about her career journey, leading with heart, and why HR shouldn't be so complicated.---- 

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes "Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer" by Felix Y. Feng, et al published January 31, 2025. Come back for the next episode where JCO Precision Oncology Conversations host, Dr. Rafeh Naqash interviews the author of the JCO PO article discussed, Dr. Tim Showalter. TRANSCRIPT Natalie DelRocco: Hello and welcome to JCO Precision Oncology Article Insights. I'm your host Natalie Del Rocco. Today, we'll be discussing the article, “Digital Pathology-Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer.” We will also be discussing the accompanying editorial, “Leveraging Artificial Intelligence to Improve Risk Stratification in Nonmetastatic Castration-Resistant Prostate Cancer.” So, we're going to start by summarizing the original report and then we'll jump into a few of the high-level interpretations that were supplied by the editorial.   The original report by Feng et. al. describes the application of multimodal artificial intelligence to data collected on a nonmetastatic castration-resistant prostate cancer. We will call this disease moving forward NMCRPC, a Clinical Trial. So, we're looking at data from an NMCRPC clinical trial. The SPARTAN trial was a randomized phase three trial and this study compared metastasis-free survival as the primary endpoint for those treated with traditional androgen deprivation therapy or ADT to those treated with androgen deprivation therapy plus apalutamide. Other secondary endpoints included progression-free survival and overall survival, but the primary endpoint there was metastasis-free survival or MFS. This study found that the addition of apalutamide resulted in a significantly longer median metastasis-free survival compared to androgen deprivation therapy alone. And we should note that this is a double-blind placebo-controlled trial. In the overall study, 1,207 patients participated and over the course of this study histopathology slides were collected and they were digitized for future use. And that future use is what we are going to be discussing today.  The authors do note that there are currently no good biomarkers for use in NMCRPC. The authors seem to be inspired by the ArteraAI prostate test, which was a recent application of multimodal artificial intelligence models. But in localized prostate cancer as opposed to NMCRPC, the authors constructed a multimodal artificial intelligence model or an MMAI model. They applied this to the SPARTAN trial with the intention of developing a risk score that could be used for risk stratification in NMCRPC. And we should note here that multimodal artificial intelligence or MMAI is a broad class of artificial intelligence models, and they can analyze different types of data at one time, hence the term multimodal. So in this example, the author's primary data source of interest were those digitized histopathology images because histopathology tells you a lot about NMCRPC. The authors though also wanted their model to consider traditional clinical factors that are known to be prognostic such as Gleason score, tumor stage, PSA level, and age. So those two different types of data, those histopathology images and that traditional clinical data are the two different types of data that make this model multimodal. So we should note here importantly, after dropping missing data, 420 patients contribute to this model, the MMAI model.  The authors generate a risk score from this MMAI model and they categorize that risk score into low, intermediate, and high risk groups using clinical knowledge. The authors found in their results that an increase in this MMAI risk score was associated with an increased hazard of metastasis-free survival event with a hazard ratio from a Cox proportional hazards model of 1.72. To summarize how the authors arrived here, they derived a risk score from this MMAI model which incorporates both imaging and regular data. They plugged this risk score into a Cox proportional hazards mode,l modeling metastasis-free survival and they found that an increase in that MMAI based risk score is associated with increased hazard of metastasis-free event with a hazard ratio of 1.72, which is quite large. Additionally, the risk score seemed to be associated with PFS2 and OS, which were two of the secondary endpoints from the SPARTAN clinical trial, though the effect sizes were more modest. Those are the highlights from the original report, the methods and the results.  The accompanying editorial notes that both histopathology and Gleason score specifically are very critical to understanding prostate cancer, and Gleason score alone is not sufficient to summarize the complexity of the disease, although it is a well validated prognostic factor for prostate cancer. So this makes MMAI an excellent tool in the setting described by the authors. We have an existing prognostic factor that doesn't describe the entire picture of the disease by itself and so we can use those digitized histopathology slides to help bolster our understanding and provide the model more information. MMAI allows you to do this because it can take in different types of data. So that was the main conclusion of the editorial.  They also summarize a number of recent validations of MMAI models in prostate cancer research, noting that it will be an important tool for risk stratification and has already been shown to outperform classical techniques. The editorial though does highlight a number of weaknesses of this paper, limitations and I think the most important one to highlight, and we touched on this earlier, is that 420 patients from the SPARTAN clinical trial contributed to the development of this MMAI score. That is a small proportion of the roughly 1200 patients that did participate in the SPARTAN clinical trial. So we have a small subgroup analysis that can be limiting and this model will need to be validated in a broader population in the future.   Thank you for listening to JCO Precision Oncology Article Insights. Don't forget to give us a rating or a review and be sure to subscribe so that you never miss an episode. You can find all ASCO shows at asco.org/podcasts.    The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.      

Michael Walsh, CEO of Cariloop, joined us on The Modern People Leader. We discussed the caregiving challenges facing employees today, how companies can better support working caregivers, and the data-backed insights from Cariloop's Top Needs Report.---- 

Cooper Schwartz: Monetizing Content: How Top Publishers and Brands Maximize Reach and Revenue Impact“The brands that win aren't just the ones with the biggest budgets—they're the ones that strategically align performance and brand marketing to maximize reach and revenue.” That's a quote from Cooper Schwartz and a sneak peek at today's episode.Hey there, I'm Kerry Curran, Revenue Growth Consultant, Industry Analyst, and host of Revenue Boost: A Marketing Podcast.Every episode, I sit down with top experts to bring you actionable strategies that drive real revenue results. If you're serious about growth, hit subscribe to stay ahead of your competition.In this episode, titled Monetizing Content: How Top Publishers and Brands Maximize Reach and Revenue Impact, Cooper Schwartz, Head of New Business and Growth at Money Group, shares his expertise.In a crowded digital landscape, content alone isn't enough. Brands need a strategy that turns visibility into real revenue. Cooper and I discuss strategies for leveraging publisher partnerships to create high-impact, holistic, cross-channel digital programs that drive both reach and ROI.We dive into the winning formula for balancing performance marketing and brand strategy—and how to dominate non-branded paid search while outmaneuvering your competition.Stay tuned until the end, where Cooper shares actionable strategies to optimize content for revenue growth. Let's go!Kerry Curran, RBMA (00:01.107)Welcome, Cooper! Please introduce yourself and share a bit about your background and expertise.Cooper Schwartz (00:07.534)Hi, Kerry. Thanks for having me. My name is Cooper Schwartz, and I am the Head of New Business and Growth at Money Group, a portfolio company that has been around for about 11 years. We own notable brands like Money.com and ConsumersAdvocate.org, as well as proprietary technology like NavChain. I'm also one of the founding partners and have been with the company for 11 years.I was actually the first employee. I originally came from a therapy background—my mother is a therapist, and I thought I would follow in her footsteps. However, two of my close friends—one with 10 years at Google and the other at SEO Moz—convinced me to jump into affiliate marketing and help build this company. So here I am today, still finding opportunities in the market and excited to talk with you.Kerry Curran, RBMA (01:02.843)Awesome, thanks, Cooper! I had no idea about your therapy background. We could totally pivot and have a different conversation! I always say marketing is a lot like psychology—it plays a strong role in what we do, so I'm sure that background strengthens your expertise.Anyway, I'm excited to have you here because I know you have a ton of valuable platforms.Cooper Schwartz (01:09.484)Yeah, yeah.Kerry Curran, RBMA (01:29.617)You have a range of brands and technology under Money.com, so I'd love to hear more about how you're helping brands navigate their business challenges. When brands or agencies reach out to build a partnership with you, what are they typically looking for?Cooper Schwartz (01:51.672)You're right—Money.com is a strong domain. Before it became Money.com, it was Money Magazine, a 50-year-old brand that people have nostalgia for. It was all about planning for the future and sharing insights on managing finances.Today, brands still want to be aligned with the Money brand. But we don't just offer content alignment—we provide a variety of campaigns and marketing opportunities. Many brands approach us saying, “We love the brand, we love the content—how can we work together?” That's a great starting point for the many solutions we offer.From non-branded paid search to placements across our ad network of about 150 publishers, we help brands engage with their audience in unique ways. Some of these publishers might be seen as competitors, but in reality, they're “frenemies.” We help brands leverage content, align with our brand, activate paid search strategies, and secure placements on other high-authority sites, all while simplifying the management process.Kerry Curran, RBMA (03:37.691)That's great. It sounds like brands really value the partnership and brand equity you offer. Can you walk us through how you start these relationships and build custom strategies to increase their awareness and authority?Cooper Schwartz (04:03.192)Sure! There's always an initial “interview” process—almost like dating. Not to take it back to therapy, but it's about getting to know the brand:What are their needs?Who is their target audience?What are their expectations?What are their key performance goals?We get a lot of inbound interest because money impacts nearly every industry. But we have to ensure alignment goes both ways—not just that they align with our audience, but also that we can effectively reach their audience.At our scale, we also consider resources. Can we accommodate the brand in a way that sets them up for success? We prioritize enterprise-level partnerships that move the needle for both companies. That often means ensuring the investment in a given category can be six or seven figures annually—we need to create impact on both sides.Once we've established alignment—brand fit, budget, resources—we dive into which marketing channels make sense:Are they already running paid search? If not, why?How can we help them expand their shelf space on Google?Is brand awareness the priority? If so, we can integrate them into our franchise content like Best Places to Live, Best Hospitals, Best Colleges, which reach wide audiences.Are they struggling to get placements in high-authority content? If so, we can help them secure placements on Forbes, NerdWallet, CBS News, CNN, and others.Kerry Curran, RBMA (06:53.058)That's great! I love that you have such a wide portfolio of solutions that are fully customized to each brand's goals.So, let's say an enterprise brand comes to you for a rebrand, product expansion, or new launch. You work with them to align with the right publishers and strategies. Can you share a specific example of a successful partnership?Cooper Schwartz (07:39.918)Sure! One that I'm especially proud of is our partnership with ADT.We've worked with ADT for about eight or nine years, originally in non-branded paid search—helping them reach high-intent consumers who were still undecided. Over time, our relationship evolved into exploring additional channels.Last year, we launched a sponsorship activation for Money's Best Places to Live, working closely with ADT's PR, media acquisition, and marketing teams. The goal was to integrate ADT's branding into content about protecting the best places to live.This was a multichannel activation that included:Social media campaignsVideo contentTargeted PR effortsWeekly performance check-insThe result? A high-impact security hub on Money.com featuring ADT across 100+ articles. It was a strategic, elegant execution.Not only did we secure ADT placements on our own sites, but we also helped them get featured on CBS News, The New York Post, and other major publishers. This is the kind of holistic strategy that allows brands to gain visibility across multiple trusted sources.Kerry Curran, RBMA (10:34.345)That's an excellent example! It really demonstrates how brands can layer multiple channels—from paid search to PR to content—to create a unified, impactful strategy.Let's shift gears to AI and Google's generative search results. How do your strategies help brands compete with AI-driven summaries at the top of search results?Cooper Schwartz (20:43.342)Great question! One core belief we've held is that editorial integrity matters. We prioritize keeping a human voice in our content while leveraging AI in strategic ways.Here's our approach:Investing in real writers & editors – AI can assist, but human oversight ensures depth and quality.Creating content clusters – Instead of one-off articles, we develop deep, interconnected content that builds expertise and authority.Partnering with already-successful publishers – Instead of relying solely on our content, we collaborate with trusted media brands that are already ranking well.The reality is, the pie is big enough. Rather than fighting for every ranking, we focus on working with the best—helping publishers monetize better while delivering results for our partners.Kerry Curran, RBMA (25:25.383)That's a smart approach. So, for brands listening today—what's the first step if they want to explore this strategy?Cooper Schwartz (25:40.910)Start by researching who dominates your industry's review space. Look at organic rankings, paid search, and media partnerships. If you see competitors investing in multiple touchpoints, that's a sign they're onto something.Then, reach out! You can contact me at cooper@money.com or find me on LinkedIn.Kerry Curran, RBMA (26:07.537)Awesome! We'll include those links in the show notes. Cooper, thank you so much for your time and insights today!Cooper Schwartz (26:20.098)Thank you, Kerry!Kerry Curran, RBMA Thank you for tuning in to today's episode. If you're struggling with flat or slowing revenue growth, you are not alone. That's why Revenue Boost: A Marketing Podcast, brings you expert insights, actionable strategies, and real-world success stories to help you scale faster.So if you're serious about your revenue growth, hit follow,  subscribe, and drop a five-star rating. It helps us keep the game-changing content coming, as we're dropping new episodes regularly—and you don't want to miss out.

Linda Aiello (CPO, DraftKings), Carmel Galvin (CPO, Klaviyo), and Stacey Richey (Global VP, People, Smartcat), joined us for MPL Live in Boston, Massachusetts.We talked about the current state of HR, how roles are shifting with AI, and how they're moving beyond traditional engagement metrics.---- 

Shlomit Gruman-Navot joined us on The Modern People Leader. We talked about her evolution as a people leader and how Miro is making AI learning a priority for employees. ---- 

Brandon Carson, Chief Learning Officer at Docebo, joined us on The Modern People Leader.We talked about the one thing holding companies back from adopting AI faster, why AI makes learning “scaled to one”, and why the future of work isn't about replacing humans - it's about amplifying them.---- 

This week we wrap up Black History month, and Jim's guest is one of the most consequential black marketing leaders of all time. Jerri DeVard, the Founder and CEO of BECA, the Black Executive CMO Alliance. Jerri started her career in marketing the same year Jim joined Procter & Gamble; she also started in consumer goods, working 10 years at the Pillsbury company, now part of General Mills. Jerri went on to CMO roles at Verizon, Nokia, ADT and Office Depot. Jerri was a guest on the show in July 2020. Jim and Jerri chatted through a wide ranging talk about her career, our friendship over the years, and what she has learned about leadership. Well this week, Jim will focus on her life since then, including the founding of BECA, which has been astounding in its impact. It's an honest, heart-to-heart chat–which is the only way Jerri DeVard rolls. Listen to the previous episode featuring Jeri from 2020: https://tinyurl.com/3tcmrx9rLearn more about BECA: https://blackexec.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Crystal Boysen, Chief People Officer at Sprout Social, joined us for a deep dive into People Debt. We discussed what it is, how to identify it, and specific areas where Sprout Social is focusing its efforts to address it.---- 

Brian Elliott, a leading expert on flexible work, joined us on the show.We talked about whether or not remote work is actually dead (looked at the actual data), the questions to ask when your CEO pushes for a RTO, and why a return to office won't fix bad management.----  Sign up for our upcoming webinar with ChartHop. Get Atlassian's free guide to AI-powered knowledge management Buy tickets for MPL Live Boston.---- (07:36) How Brian became a leading voice on the future of work(13:39) The origins of Slack's Future Forum and key findings(14:56) The media vs. reality: Is remote work really dead?(17:14) CEOs pushing RTO: Data-driven decision or gut feeling?(19:02) The role of real estate, stealth layoffs, and productivity concerns(23:27) The trust factor: Why some leaders struggle with hybrid models(26:35) Politics and workplace decisions: The hidden forces at play(28:34) The shift from central business districts to neighborhood economies(30:37) The future of work isn't fully remote or in-office—it's flexible(34:12) How HR leaders can push back on RTO mandates(38:19) The contradiction: CEOs demanding AI innovation while enforcing RTO(41:50) Performance management in a hybrid world: Why tracking outcomes matters(47:33) How leading companies successfully implement flexible work policies(49:30) The impact of return-to-office policies on women in the workforce(54:23) What cities will look like in a remote-first future(57:57) Five years from now: What will the workplace look like?(01:01:43) The economic realities of remote work and city tax structures----