Podcasts about gendered innovations

Show Notes for Podcast Eleven, Part 2 of seX & whY Host: Jeannette Wolfe This is a continuation of my interview with Dr. Cara Tannenbaum, Professor in the Faculties of Medicine and Pharmacy at the Université de Montréal in Canada, and Scientific Director of the Institute of Gender and Health of the Canadian Institutes of Health Research Our discussion and the following table is centered around this recent review article by Dr. Tannenbaum found in Pharmacology Research 2017 Type of experiment Traditional way Better way                  Stem cells -Male cells -Unknown sex of stem cells -Problems: in immortal cell lines the integrity of in vivo sex chromosomes diminishes over time and can complicate the identification of sex- based differences. Similarly, although normal female cells have two X chromosomes- one from the mother and one from the father- one of those chromosomes is usually turned “off”. With Stem cells however, after multiple reproductive cycles there can get something called “X skewing” in which instead of some cells turning off the maternal chromosome and others the paternal one, there is overrepresentation of one line. Conversely in “X escape”, the second X chromosome is no longer getting inactivated and this can cause trouble because too much X gene is getting expressed (for example this could lead to significant autoimmune problems)  Use and record results of both male and female cell lines Know sex & of donor      -       Include cell lines with finite life spans -       Add sex hormones to XX and XY cell -       X chromosomes house genes that influence: cellular growth, metabolism and immunity -       Y chromosomes contain genes beyond SRY (which makes testosterone), and if loss Y chromosome increased risk of Alzheimers and certain cancers Gendered Innovations group in Korea has actually labeled sex of commercial cell lines                     Lab animal Standard use of male animals -80% of traditional research done on males -Females felt to be too variable due to estrous cycle* (average of 4 days) Inclusion of female animals** -analyze data by sex -include factorial designs that allow for the identification of age or hormonal influence in outcome -Consideration of housing conditions that can lead to hormonal fluctuations Phase trials     Change began with The NIH Revitalization Phase 1 and 2 Currently it is believed that women still make up less than 25% of Phase 1 Include sex and age as independent variables   Further query if discovered sex differences are due to sex-based differences in pharmacokinetics (how our body's characteristics like our weight or liver function influence the drug) or pharmacodynamics (how the drug influences our body)  Phase 3 trials As it was believed that outside the reproductive organs that males and females were physiologically the same,  most studies focused on males and thus side effects in females were often missed or underappreciated       Report and analyze data by sex and age   Use updated statistical models to calculate appropriate sample sizes prior to starting study so that any identified differences are likely to represent valid findings     Further explore hormonal states of study participants. For example, if they are pre or post menopausal, pregnant, or if they are taking hormones such as estrogen or testosterone.   56% of participants in drug trials submitted to FDA in 2018 were women Phase 4 As this is further analysis of a drug after it hits the market, it can take a long time to pick up sex-based differences. Poster child of this is Ambien in which dosing adjustment for women took 20 years Analyze results from “real world” use of drug and its side effects by sex and age   Go back to lab to identify etiology of discovered sex or age differences   Adjust dosing when important differences are discovered Click here for a paper that nicely summarizes the reasons behind why females were underrepresented in scientific research during the 20th century. Other points    Important variables to consider when talking about biological sex Sex chromosomes X chromosome contains 1669 genes Y chromosome contains 426 genes Sex hormones We all have testosterone, progesterone and estrogen it is the ratios that differ between men and women Hormones influence us in two ways The cocktail of hormones our brain is exposed to during prenatal and pubertal development leads to permanent wiring changes in the brain. The fluctuating blips of hormones caused by multiple different triggers (like the estrous cycle or dominance posing) can lead to transient wiring changes. Depending upon specific context organizational and activational hormones can potentially influence outcome data There are new study designs that can help identify potential hormonal based differences that do not require an excessive sample size or budget Age Gender What we do (and what society allows us to do) influences our epigenetics and future gene expression. For example, our gendered professions- men work more in coal mines and women in nail salons- can influence stuff we are exposed to which in turn can influence are future gene expression.  This is further complicated by males and females having potentially different DNA modifications after exposure to the same insult. Ultimately this can make it tricky to sometimes distinguish what is a sex- based difference versus a gender one. The X chromosome has 1669 known genes on it and the Y chromosome 426 genes Miscellaneous 2017 Tetris study on decreasing PTSD intrusive thoughts after C-section.

Londa Schiebingers wissenschaftshistorische Analysen beschäftigen sich seit den 1980er Jahren intensiv mit Machtstrukturen, die die…Beitrag lesenGL-01-17: Londa Schiebinger – Gendered Innovations in Medicine and Natural Science

More at https://philosophytalk.org/shows/science-and-gender. What does gender have to do with science? The obvious answer is ‘nothing.’ Science is the epitome of an objective, rational, and disinterested enterprise. But given the history of systemic under-representation of women in science, what does it mean that science answers almost exclusively to the methodologies of men? Has male domination contributed certain unfounded assumptions or cognitive biases to the ‘objectivity’ of scientific inquiry? Is there any possibility of achieving a gender-neutral science, and if so, what would that look like? John and Ken make room at the table for Stanford historian Londa Schiebinger, author of "Gendered Innovations in Science and Engineering."

Londa Schiebinger leads a discussion with contributors of "Gendered Innovations in Science and Engineering" on how to create tools of gender analysis for use in scientific fields. (May 20, 2008)

Introduction to the Gendered Innovations in Science and Engineering II conference. Also introducing the new GISE volume. (March 13, 2008)