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Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shelby Williams.
Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shelby Williams.
Pancreatic cancer is among the most deadly forms of cancer, and it can be difficult to catch early. But there's some good news: Clinical trials of a new drug called daraxonrasib found that it doubled the survival time of patients with advanced pancreatic cancer. And some oncologists are calling it a game changer—not just for pancreatic cancer, but potentially other forms of cancer too. Ira talks with oncologist Zev Wainberg, who led a clinical trial for the drug. Plus, ALS is a degenerative disease that causes patients to lose their ability to walk, swallow and eventually to breathe. Now, there's a drug for a rare genetic form of ALS that can slow the progression or even reverse some of these symptoms. Ira talks with New York Times health and science reporter Pam Belluck about this new treatment. Guests: Dr. Zev Wainberg is a co-director of UCLA Health's GI Oncology Program. Pam Belluck is a health and science reporter for The New York Times. Other episodes you may enjoy: mRNA Vaccine For Pancreatic Cancer Continues To Show Promise How do clinical trials work, and who can participate? Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Join our Hernia Team for a review of the current controversy around preoperative optimization and the practical implications.Hosts: Dr. Maggie Bosley - @MBosleyMD Dr. Sean Orenstein - @OrensteinSean Dr. Amber Sandoval Dr. Peter Ferrin Institution: Oregon Health & Science UniversityReferences:Adverse Events after Ventral Hernia Repair: The Vicious Cycle of Complicationshttps://pubmed.ncbi.nlm.nih.gov/26206646/Risk factors for postoperative wound infections and prolonged hospitalization after ventral/incisional hernia repairhttps://pubmed.ncbi.nlm.nih.gov/24030572/lack of association between glycated hemoglobin and adverse outcomes in diabetic patients undergoing ventral hernia repair: an ACHQC studyhttps://pubmed.ncbi.nlm.nih.gov/35969297/Impact of preoperative haemoglobin A1c levels on postoperative outcomes in adults undergoing major noncardiac surgery: A systematic reviewhttps://pubmed.ncbi.nlm.nih.gov/38853752/Does active smoking really matter before ventral hernia repair? An AHSQC analysishttps://pubmed.ncbi.nlm.nih.gov/30220485/Abstinence from smoking reduces incisional wound infection: a randomized controlled trialhttps://pubmed.ncbi.nlm.nih.gov/12832959/The Association of Nicotine Replacement Therapy With Outcomes Among Smokers Hospitalized for a Major Surgical Procedurehttps://pubmed.ncbi.nlm.nih.gov/31790653/Is weight trajectory a better marker of wound complication risk than BMI in hernia patients with obesity?https://pubmed.ncbi.nlm.nih.gov/38082008/Gender, racial, and socioeconomic disparity of preoperative optimization goals in ventral hernia repairhttps://pubmed.ncbi.nlm.nih.gov/37658198/Limited or Lasting: Is Preoperative Weight Loss as Part of Prehabilitation Maintained after Open Ventral Hernia Repair?https://pubmed.ncbi.nlm.nih.gov/39907236/The impact of preoperative optimization for abdominal wall reconstruction on long-term glucose control and smoking cessationhttps://pubmed.ncbi.nlm.nih.gov/40739418/Watchful waiting as a treatment strategy for patients with a ventral hernia appears to be safehttps://pubmed.ncbi.nlm.nih.gov/26838293/Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
Do you owe your toxic aging parent everything... or nothing? Clinical psychologist Dr. Lisa Stinson, author of The Obligation Myth: Rethinking What You Owe Your Difficult Aging Parent, joins the show to unpack what happens when a critical, dismissive, or covertly narcissistic parent starts needing care — and why "I do everything" or "I do nothing" was never the real choice. We dig into the specific family roles that get assigned in childhood — the scapegoat, the golden child, the invisible child, and the enmeshed child — and how each one carries a different wound, gets triggered differently, and needs a completely different approach to setting a boundary. Dr. Stinson also breaks down how fear, obligation, and guilt (FOG) get weaponized differently depending on which role you were handed, and why your role can shift as the family system changes around you. If you've ever walked into your parent's house and instantly felt five years old again, this episode will help you understand why — and what to actually do about it. Lisa D. Stinson, Ph.D. is a clinical psychologist specializing in complex PTSD, narcissistic abuse recovery, adult children of dysfunctional families, and the psychology of toxic family obligation. Her expertise was forged through extensive experience as an active-duty Navy psychologist, where she predominantly worked with trauma patients. Dr. Stinson holds both a Master's degree and Doctorate from the California School of Professional Psychology at Alliant International University, following her undergraduate studies at the University of Alaska Anchorage. Substack: lisadstinsonphd.substack.com Website: lisadstinsonphd.com The information provided by Renee Swanson, Covert Narcissism Podcast, and CNG Life Coaching is for educational purposes only and is not to be used for diagnosis purposes and not intended to be a substitute for clinical care. Please consult a health care provider for guidance specific to your case. This material discusses narcissism in general. Renee shares stories from her personal experiences as well as from those she has talked with for several years. Her material does not claim that any specific person has narcissism and should not be used to refer to any specific person as having narcissism. Permission is not granted to link to or repost this material to support an allegation or support a claim that any specific person is a narcissist. That would be an unauthorized misuse of the material and information provided. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
If you've ever lain awake at night worrying about a client, found yourself replaying sessions in your head, or wondered where healthy compassion ends and unhealthy responsibility begins, this episode is for you.Today I've shared the single most important lesson a mentor ever taught me about surviving this work with both your heart and your humanity intact. It's a lesson that carried me through some of the hardest moments of my career—and one I now find myself passing along to therapists, coaches, and healers again and again.In this episode, you'll hear…What "critical distance" really means—and why every helping professional needs it.The early career experience that forever changed the way I care for clients.The warning signs that you're becoming emotionally over-involved.Practical ways to regain perspective before burnout takes hold.My message here is not that you should care less… It's that you must care wisely... so that you can continue serving people with compassion, clarity, and longevity—without sacrificing yourself in the process.If this episode resonates with you, I'd love to hear your story! Have you ever struggled to maintain healthy emotional boundaries in your work? Send me a note—I read every email.And if you're enjoying the deeper conversations we've been having here lately, would you consider leaving a quick five-star review? It really does help more people discover the show. And you know how much I appreciate that. And I appreciate you for being here. ~WendyP.S. Remember: You are responsible to your clients. You are not responsible for your clients. Sometimes that distinction is the healthiest gift you can give both yourself and the people you serve._______________Free Resources: Get your copy of some of my most popular tools and guides right here! >> https://www.wendypittsreeves.com/free-resourcesQuick Start Consult: If you're ready to get out of your own way, this 1:1 coaching work session could make all the difference. Learn more here.Want to be a Guest on Ideal PracticeTM? Submit your application here. Support the showWendy Pitts Reeves, LCSWHost, Ideal PracticePrivate Practice Coach and Mentorwww.WendyPittsReeves.comWendy@WendyPittsReeves.com
This throwback episode from 2023 features Dr. Meylinda Meredith. Zach and Kevin sit down with Meylinda, a fellow UMKC dental school alumnus and current clinical faculty member teaching operative dentistry. They dive into a fascinating discussion comparing private practice associateships with a career in dental education, exploring everything from the perks of academic vacation time to the unique traits of Gen Z dental students and how "just-in-time" learning changes the way they absorb material. The trio also discusses the modern integration of digital scanning versus traditional PVS impressions in a dental school setting, before wrapping up with a fun round of UMKC dental trivia. Some links from the show: UMKC School of Dentistry Alumni Page Stevenson Dental Solutions YouTube Join the Very Clinical Facebook group! Join the Very Dental Facebook Group using one of these passwords: Timmerman, Paul, Bioclear, Hornbrook, Gary, McWethy, Papa Randy, or Lipscomb! The Very Dental Podcast network is and will remain free to download. If you'd like to support the shows you love at Very Dental then show a little love to the people that support us! We're proud to be supported by the folks at Net32! I'm a big fan of the Bioclear Method! I think you should give it a try and I've got a great offer to help you get on board! Use the exclusive Very Dental Podcast code VERYDENTAL8TON for 15% OFF your total Bioclear purchase, including Core Anterior and Posterior Four day courses, Black Triangle Certification, and all Bioclear products. Crazy Dental has everything you need from cotton rolls to equipment and everything in between and the best prices you'll find anywhere! If you head over to verydentalpodcast.com/crazy and use coupon code "VERYSHIP" you'll get free shipping on your order! Go save yourself some money and support the show all at the same time! The Wonderist Agency is basically a one stop shop for marketing your practice and your brand. From logo redesign to a full service marketing plan, the folks at Wonderist have you covered! Go check them out at verydentalpodcast.com/wonderist! Enova Illumination makes the very best in loupes and headlights, including their new ergonomic angled prism loupes! They also distribute loupe mounted cameras and even the amazing line of Zumax microscopes! If you want to help out the podcast while upping your magnification and headlight game, you need to head over to verydentalpodcast.com/enova to see their whole line of products! CAD-Ray offers the best service on a wide variety of digital scanners, printers, mills and even their very own browser based design software, Clinux! CAD-Ray has been a huge supporter of the Very Dental Podcast Network and I can tell you that you'll get no better service on everything digital dentistry than the folks from CAD-Ray. Go check them out at verydentalpodcast.com/CADRay!
Join Elevated GP by visiting THEELEVATEDGP.COM In Part 2 of his conversation with Dr. Melissa Seibert, periodontist Dr. David Wong unpacks why patients actually decline treatment — and it's rarely the money or the dentistry. It's the connection you failed to build. He walks through the soft-skill work that's defined his career: reading where a patient sits on the decision-making scale, designing a separate consultation room so he can sit beside patients instead of across from them, and disarming fight-or-flight by finding common ground fast. He also shares one of the most underrated networking moves in dentistry — joining your local Chamber of Commerce — and how it helped him launch a practice from scratch. The second half pivots to the clinical: ridge preservation as a high-ROI skill for general dentists, how to think about bone graft material selection without getting overwhelmed by terminology, membrane selection for beginners through advanced users, and the specific brands David reaches for day to day. About the Guest Dr. David Wong is a board-certified periodontist and Fellow of the International Congress of Oral Implantologists — the only periodontist in Oklahoma to hold that distinction. He completed his periodontal training at the University of Missouri-Kansas City as chief resident, earned advanced implant and oral plastic surgery credentials from Temple University and the Misch International Implant Institute, and has published in the field of oral plastic surgery. Beyond his clinical work, he has spent his career studying the art of case presentation and patient communication. Chapter Markers Time Section 00:00 Pre-roll: Elevated GP 00:49 Welcome and episode preview 02:14 Why patients decline treatment — the connection problem 04:24 The mistake of trying to build trust in one appointment 05:06 Recommended books and resources on soft skills 06:44 Why David joins mastermind groups outside dentistry 08:35 The Chamber of Commerce — an untapped networking resource 10:41 How the Chamber helped David launch his practice from scratch 11:20 Ridge preservation as a high-ROI skill for GPs 12:30 Honest take on dental photography ROI 13:27 Bone graft material selection — keeping it simple 14:38 Allografts vs. xenografts and the global supply reality 15:18 Membrane selection: beginner, intermediate, advanced 16:19 The handling reality of amnion-chorion membranes 17:19 When primary closure matters 17:53 Non-resorbable / PTFE membranes — when they help, when they hurt 19:04 Subscribe CTA 19:20 The specific brands David uses day to day 20:35 The one thing David has invested most in: case presentation 21:09 Inside David's consultation room setup 23:04 Three resources for learning case presentation Key Takeaways On why treatment plans get declined. When patients say "I'll go home and think about it," dentists default to "they don't value the dentistry" or "they can't afford it." David's argument: the most common reason is that you didn't build trust or form a connection. People will spend $20,000 on a European vacation but not on asymptomatic dental work — that's a comparison about trust and felt need, not budget. Connection is a long game, not a five-minute pitch. New dentists try to close trust in a single appointment. David's reframe: you'll see this patient over years. Foster the relationship as long as it takes, and they will do the treatment — maybe not all at once, but eventually. The "I'm the doctor, you're the patient" model breaks in fee-for-service. Patients in a fee-for-service practice are decision-makers, not compliant subjects. You have to meet them as one. Design the room around the conversation. For any case over roughly $1,500, David moves the patient to a dedicated consultation room and sits side-by-side at a table — not across the operatory chair. He pays attention to where he's seated relative to the patient and the door. He has even recorded his own case presentations on camera and had them coached. The Chamber of Commerce is one of the most underused networking moves in dentistry. Every city has one. Dues are minimal or free. You get a room full of local entrepreneurs — publishers, contractors, surgeons, service providers — solving the same problems you are, just in different industries. When David launched his practice from scratch, the Chamber funded part of his open house, ran his ribbon-cutting, and brought a crowd. Get your CE ROI right. Start with skills that pay dividends immediately — molar endo, ridge preservation/socket grafting. They have low downside (a missed socket graft is no worse than not grafting at all), short learning curves, and you'll actually use them weekly. "Sexy" CE without immediate clinical application sits unused. Keep ridge preservation simple. Don't get lost in the 70/30 vs. 50/50 mineralized/demineralized debate. David teaches just two categories: mineralized cortical bone, or mineralized cortical-cancellous bone. That's it. For membranes, beginners should default to a long-lasting resorbable collagen membrane. The fancier options (cross-linked, titanium-reinforced, amnion-chorion, PTFE) are handling-skill problems before they're outcome problems. Case presentation isn't about "salesy words." It's about reading non-verbal cues, responding appropriately, and conducting the conversation — not delivering the right script. Notable Quotes "It's not necessarily just because they don't want it. It's not necessarily just because of financial constraints. It's because we didn't build the trust. We didn't form that connection." "You're going to see this patient more than one time. Hopefully ten years from now they're still your patient — so you have to foster that relationship as long as it takes." "We'll spend $20,000 on a European vacation. We won't spend $20,000 on dentistry when we're asymptomatic and have no known issues." "You spend all that money [on a photography setup] and you still use your intraoral camera to sell single-tooth dentistry. Good job." "Two, three years later, I am the guy where they're just like, 'Dr. Wong, just take my money and do it.'" "A lot of times dentists think that case presentation is using the right words — salesy words. That's not it at all." Resources Mentioned Books on influence, communication, and mindset Influence — Robert Cialdini Pre-Suasion — Robert Cialdini (the "second one" referenced in the conversation) Vanessa Van Edwards' work (and her courses on the Masterclass app) How to Win Friends and Influence People — Dale Carnegie How We Decide — Jonah Lehrer Books by Jonah Berger The E-Myth Revisited — Michael Gerber As a Man Thinketh — James Allen (~50 pages, mindset) Organizations and programs Your local Chamber of Commerce Local Toastmasters (for speaking) Spear Study Club masters program The Elevated GP (Dr. Seibert's virtual study club) Paul Homoly's case presentation program Clinical products David uses day to day Membrane: Mem-Lok resorbable collagen (BioHorizons) — current default Membrane (when available): OsseoGuard / Ossix Plus (Dentsply Sirona) — currently on hold Bone graft: MinerOss mineralized cortical or cortical-cancellous (BioHorizons) Bone graft (alternate supplier): Symbios mineralized cortical (Dentsply Sirona)
AI in medtech is most valuable when it supports better clinical decisions, not when it replaces clinicians. In this episode, Alexis Anderson speaks with Will Mauldin, Co-Founder and CEO of Rivanna Medical, live from DeviceTalks Boston. Will explains how Rivanna is bringing AI-enabled imaging to clinical settings where providers have traditionally relied on blind or manual procedures, beginning with epidural anesthesia guidance and expanding into fracture detection. He shares how the company's handheld spine guidance technology helps clinicians visualize the epidural space, use AI as a confirmation tool, and build confidence through consistent outcomes. Will also discusses broader medtech trends around AI, automation, connected devices, and robotics, along with funding challenges for mid-stage companies and Rivanna's upcoming FDA milestones. Tune in and learn how AI-enabled imaging can improve safety, reduce bottlenecks, and support clinicians in high-demand care environments. Resources Connect and follow Will Mauldin on LinkedIn. Follow Rivanna Medical on LinkedIn and explore their website.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter View our full terms of use Renato Tomioka is a leading expert in reproductive medicine and gynecologic surgery whose unique skills allow him to diagnose and treat some of the most impactful yet frequently overlooked conditions affecting women's health. In this episode, Renato explores endometriosis and adenomyosis, explaining what these conditions are, why they often go undiagnosed for years despite affecting millions of women worldwide, and how advances in MRI and specialized ultrasound are transforming diagnosis beyond traditional surgical laparoscopy. He discusses the decision-making process behind hormonal therapy versus surgery, how treatment strategies change when fertility preservation is a priority, and where IVF fits into the care pathway for women with endometriosis, adenomyosis, or age-related fertility decline. Renato also examines the profound effects of female age on egg quality and quantity, including the accelerating rise in chromosomal abnormalities after age 35, highlights common mistakes in both surgical and fertility management, and shares promising developments on the horizon for treating these conditions and preserving fertility. Follow Dr. Tomioka's work: Instagram: @dr.renatotomioka; Website: Renato Tomioka, M.D., Ph.D. We discuss: 0:00:00 - Intro 0:00:11 - Endometriosis: definition, prevalence, infertility risk, and theories of disease development 0:09:03 - The biology of endometriosis: estrogen dependence, progesterone resistance, and tumor-like growth mechanisms 0:13:25 - Adenomyosis explained: how it differs from endometriosis, why it develops, and its impact on reproductive health 0:18:52 - Recognizing endometriosis and adenomyosis: the "6 Ds" of endometriosis and key differences in clinical presentation 0:22:09 - Uterine fibroids: classification, symptoms, and the importance of fibroid location for bleeding and fertility 0:24:09 - Understanding endometriosis pain: lesion-driven pain, nerve involvement, central sensitization, and the importance of early treatment 0:28:26 - Endometriosis in young women: rising prevalence, delayed diagnosis, and barriers to care 0:33:11 - Modern diagnosis of endometriosis: specialized ultrasound, MRI, and the decline of diagnostic laparoscopy 0:45:52 - Clinical case example #1: Managing endometriosis in a young woman seeking pain relief while preserving future fertility 0:54:10 - Clinical case example #2: Comparing treatment strategies for symptom control versus fertility 1:01:24 - Endometriosis and fertility: the roles of age, embryo quality, IVF, and surgery 1:11:50 - Clinical case example #3: Managing adenomyosis after failed IVF transfers to improve implantation and pregnancy outcomes 1:20:51 - The funding gap in endometriosis research: disease burden, economic impact, and growing awareness 1:22:01 - Clinical case example #4: Surgical decision-making in endometriosis—balancing pain relief, fertility preservation, and common treatment pitfalls 1:27:43 - Common misconceptions about fertility: maternal age, embryo aneuploidy, the inefficiency of human reproduction, and the limits of IVF 1:34:23 - Elective egg freezing: timing, success rates, the fertility funnel, and the tradeoffs of fertility preservation 1:45:49 - Emerging fertility technologies: mitochondrial replacement, ovarian tissue preservation, stem-cell-derived eggs, and current limitations 1:55:10 - The future of endometriosis treatment: new guidelines, biologic therapies, and unanswered questions about IVF 1:58:30 - Why earlier diagnosis matters: reducing years of suffering from endometriosis and adenomyosis Connect With Peter on Twitter, Instagram, Facebook and YouTube
This Week In Startups is made possible by:Agree - https://agree.comQuo - https://quo.com/TWiSTSuperhuman - https://superhuman.comToday's show:In this double-header, Jason and Lon chat with Louis Phillips, founder of the gamified running app INTVL, which turns a quick job around the block into a worldwide turf war competition. Find out how he grew the app to over 1 million downloads without any paid ads, just making videos from his home office.PLUS Alex sits down with Alice Zhang, CEO of Verge Labs, which pivoted from making drugs to building the AI infrastructure that helps pharma companies develop their own treatments. Find out how they accumulated one of the world's largest proprietary brain datasets and why brain tissue is the “LiDAR of neuroscience.”Guests:INTVL: https://www.intvl.com.au/INTVL on Instagram: https://www.instagram.com/intvl.appLouis Phillips on Instagram: https://www.instagram.com/louisphillips12Verge Labs: https://vergelabs.com/Alice Zhang on X: https://x.com/AliceXinliZhangRelevant LinksMeta's Ad Library: https://www.facebook.com/ads/library/Strava: https://www.strava.com/Pokémon Go: https://pokemongo.com/Fitbod: https://fitbod.me/Tonebase: https://www.tonebase.co/Calm: https://www.calm.com/Hamilton Island official site: https://www.hamiltonisland.com.au/“Mr. Inbetween” trailer: https://www.youtube.com/watch?v=EooRG3QhQOYArticle: “Verge Genomics Rebrands as Verge Labs”: https://trial.medpath.com/news/verge-genomics-rebrands-as-verge-labs-following-als-drug-trial-failure-pivots-to-ai-driven-target-discoveryEli Lilly: https://www.lilly.com/Chai Discovery: https://www.chaidiscovery.com/Noetik: https://www.noetik.ai/Tempus: https://www.tempus.com/Timestamps:0:00 Louis on building in Melbourne, Australia7:44 Why INTVL ignores how fast you run9:59 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life!15:52 Using gamification for good19:10 Powering INTVL's impressive growth19:55 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST26:16 The future of TWiST Australia27:14 Will AI ever cure cancer?27:54 Inside Verge's rebrand30:31 Superhuman - Get AI that works where you work. Unlock your Superhuman potential at https://superhuman.com32:01 Brain tissue as "ground truth"36:01 Why brain tissue is so valuable as data43:52 Verge's Eli Lilly partnership51:34 "You're going to tell me when I'm going to die"56:11 How AI could impact drug prices58:19 Clinical trial FAILS and how to move onSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com
Dr Mary Sims is an AuDHD (autistic with attention deficit hyperactivity disorder, and some overlap with obsessive compulsive disorder) who has both dealt with neurodivergent patients in crisis and been one herself.In Episode One of Clinical Misfits, Dr Mary describes in detail a unique way to identify neurodivergent people who are approaching or in the middle of burnout, who she calls Clinical Misfits. She emphasizes a gestalt approach to diagnosis, looking for patterns, in true autistic style, rather than focusing on specific organ systems, or parts of the body, and the afflictions thereof.The episode recommends a thorough examination of all parts of a person's life, looking for numerous vague symptoms, in many different categories, that have characteristics commonly seen in neurodivergent people in crisis. Below are links to materials that may be helpful.Clinical ToolsList of Podcasts that are helpful to neurodivergent people facing burnout:Autistic Culture PodcastBeyond Six SecondsMeet My Autistic BrainDivergent Conversations/ Divergent InsightsWebpages dedicated to caring for neurodivergent people in affirming, non-ableist ways: Allbrainsbelong.orgIf you know of other resources, please contact Dr Mary: maredog3d@icloud.com
Send us Fan MailWhat would it really mean to shorten neonatology fellowship training to two years? In this episode, Ben and co-host Dr. Shetal Shah sit down with three division heads, Dr. Jill Maron (Brown), Dr. Patrick McNamara (University of Iowa), and Dr. Sarah Taylor (Yale), to examine the ABP's proposed changes from the perspective of those who run major academic NICUs. From the operational and financial strain of losing an entire class of third-year fellows, to the erosion of scholarly development, dwell time, and faculty wellbeing, the conversation makes clear that the costs of this proposal go far deeper than the curriculum. How do you staff an 80-bed NICU without junior fellows? Who funds the gap? And what happens to the next generation of academic neonatologists if we train them in isolation from the very experiences that shape their identity as clinicians and scholars?Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Sexually transmitted infection (STI) management continues to evolve, with new treatment options, prevention strategies, and practice considerations that are important for pharmacists to understand. This course reviews recent updates in STI care, including newly approved oral therapies for gonorrhea and doxycycline post-exposure prophylaxis. You will be better prepared to recognize practice-relevant changes and support evidence-based STI prevention, treatment, and patient counseling. HOSTRachel Maynard, PharmDGameChangers Podcast Host and Lead, Clinical & Partnership Education, CEimpactGUESTFrancisco Franco, PharmD, MS, AAHIVPRegistered Store Manager,Walgreens Pharmacists, REDEEM YOUR CPE HERE!CPE is available to Health Mart franchise members onlyTo learn more about Health Mart, click here: https://join.healthmart.com/PRACTICE RESOURCEReceive the exclusive Practice Resource to use as a reference guide for this episode by enrolling in the course. Click here to enroll!CPE INFORMATION Learning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe recent updates in STI treatment and prevention that are relevant to pharmacy practice.2. Compare emerging strategies for managing gonorrhea and STI post-exposure prophylaxis.Rachel Maynard and Francisco Franco have no relevant financial relationships to disclose.0.075 CEU/0.75 HrUAN: 0107-0000-26-241-H01-P Initial release date: 6/22/2026Expiration date: 6/22/2027Additional CPE details can be found here.
Sexually transmitted infection (STI) management continues to evolve, with new treatment options, prevention strategies, and practice considerations that are important for pharmacists to understand. This course reviews recent updates in STI care, including newly approved oral therapies for gonorrhea and doxycycline post-exposure prophylaxis. You will be better prepared to recognize practice-relevant changes and support evidence-based STI prevention, treatment, and patient counseling.HOSTRachel Maynard, PharmDGameChangers Podcast Host and Lead, Clinical & Partnership Education, CEimpactGUESTFrancisco Franco, PharmD, MS, AAHIVPRegistered Store Manager,WalgreensGET CE FOR LISTENING!Stay Compliant. Grow Clinically. Practice with Confidence. Pharmacist CE Subscription: All your CE in one convenient subscription.All episodes, CE, and Practice Resources for the GameChangers Clinical Update is included with your Pharmacist CE Subscription. But wait…there's even more!The Pharmacist CE Subscription includes: - Compliance and licensure CE - GameChangers Clinical Updates- Practical continuing education across patient care topics *The subscription does not include microcredentials or certificates, which are available separately for pharmacists seeking specialized service training. Purchase Now!PRACTICE RESOURCEReceive the exclusive Practice Resource to use as a reference guide for this episode by purchasing the Pharmacist CE Subscription. CPE REDEMPTIONThis course is accredited for continuing pharmacy education! Click the link below that applies to you to take the exam and evaluation to claim credit:If you are already enrolled in this course, click here to redeem your credit. To purchase the Pharmacist CE Subscription and claim your CPE credit, click here or to purchase this course individually, click here. CPE INFORMATIONLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe recent updates in STI treatment and prevention that are relevant to pharmacy practice.2. Compare emerging strategies for managing gonorrhea and STI post-exposure prophylaxis.Rachel Maynard and Francisco Franco have no relevant financial relationships to disclose.0.075 CEU/0.75 HrUAN: 0107-0000-26-241-H01-P Initial release date: 6/22/2026Expiration date: 6/22/2027Additional CPE details can be found here.Follow CEimpact on Social Media:LinkedInInstagram
SIBO & Parasite Antimicrobial Protocol: https://drruscio.com/biofilm-protocol/?nab=0&utm_source=youtube Elemental Diet: https://store.drruscio.com/pages/elementalheal Triple Therapy Probiotics: https://store.drruscio.com/products/triple-therapy-probiotic Gut Rebuild Nutrients: https://store.drruscio.com/products/gut-rebuild-nutrients-powder-chocolate?srsltid=AfmBOopnMhnrTlDklAWPUIyuoOFwM3FwTahLXX4888KzfgBc-Ym9bUvt Parasites are an often-overlooked factor in chronic gut symptoms, food intolerance, histamine-type reactions, fatigue, and cases where patients feel stuck despite addressing SIBO, Candida, or other common gut imbalances. In this episode, Dr. Ruscio, Dr. Jake Vonfeldt, and Dr. Scott Spiridigliozzi discuss common parasites like Giardia, Cryptosporidium, Blastocystis, pinworms, and helminths, why standard testing can miss them, and how clinical history can help determine when parasites deserve closer consideration. They also share both natural and pharmaceutical parasite protocols, along with practical guidance on when each approach may be appropriate. ✅Start healing with us! Learn more about our virtual clinic: https://drruscio.com/virtual-clinic/
Are you looking for a fun, stress-free way to help your child improve their reading skills? In this episode of the Homeschool Yo Kids Podcast, we explore how the power of music and singing can transform literacy for struggling readers and build lasting confidence.Host Jae sits down with Carlo Franzblau, the developer of Tune Into Reading, and consultant Maya Fombelle to discuss a unique approach to education. What started as a software to help people carry a tune evolved into a research-backed literacy program that has helped thousands of students make dramatic gains. We discuss the science behind why singing works for the brain, how repetitive reading builds fluency, and the deep connection between reading struggles and student behavior.Maya shares her heartwarming experiences as a school counselor seeing kids move from shame to pride as they master new words. Carlo explains the structure of the program, which includes vocabulary building, pitch tracking, and comprehension quizzes. You will also learn about the extensive research from the University of South Florida that proves students can gain a full grade level in reading in just 12 weeks. If you have been searching for a way to make learning to read feel less like a chore and more like a celebration, this episode is for you.https://www.tuneintoreading.com/Maya Fombelle is a consultant with Tune into Reading. She has spent her life working withat-risk children in a variety of capacities. She practiced law for 35 years, beginning as aProsecutor in Macon County, Illinois. She developed an interest in a Public Defender positionserving as Guardian Ad Litem for children who were removed from their homes due to abuseand neglect. During her tenure as a PD, she was also assigned as counsel for juveniledefendants and patients facing involuntary mental health commitment. When she and herhusband (Greg) started their family, she took a hiatus from practicing law until their childrenbegan kindergarten. When she returned to work, she and her husband started their own lawfirm. Maya focused on defending youthful offenders during her time at the firm. As a trialattorney for many years assisting children after they had been arrested, Maya decided that shewanted to change careers and be a part of improving the trajectory for at-risk students. Shereturned to graduate school, earning an MS with dual licensure in Clinical and SchoolCounseling. She began her school counseling career in a Catholic High School, where sheworked 4 years until a position opened in a Title I high needs school. Maya worked in a largepublic school district for 3 and a half years until retiring to Florida. During her time at a lowperforming school, (bottom 2% in ELA) Maya began researching ways to help students recovertheir grade level reading skills. She discovered Tune into Reading and the rest is history!Chapters0:00 Intro and meet the guests3:15 The 25 year journey of Tune Into Reading7:45 How singing helps with visual feedback and pitch11:20 The benefits of repetitive reading through music15:10 Breaking down the four parts of a song lesson19:35 Addressing student shame and behavior through literacy24:15 Improving reading confidence in elementary students28:50 Dealing with the national literacy crisis33:10 Research and peer reviewed results from USF37:45 Accessing the program through Step Up for Students42:20 The importance of self care for parents and teachers47:10 Final advice for parents of struggling readers50:30 ConclusionVisit the Tune Into Reading website to learn more about their 12 week guarantee and the 4 week trial program. Make sure to subscribe to the podcast for more resources to support your homeschooling journey and share this video with a fellow parent!#homeschooling #literacy #readingtips #educationalmusic #tuneintoreading
The diet world just picked another champion. This time it's intermittent fasting. The case for it is real, and so is the 38% dropout rate. This episode looks at what the data shows about both approaches, what the neuroscience says about where sustainable fat loss lives, and what question every protocol conversation is actually trying to ask. In This Episode: 1. The debate is a setup. Comparing protocols means staying inside the diet industry's frame. The tool isn't the problem. The relationship underneath it is. 2. Intermittent fasting works for one reason: total calorie reduction. Clinical trials confirm real results and a 38% dropout rate, higher than participants who cut calories with no time-based structure at all.3. The body reads a fasting window as a starvation signal. Cortisol rises. Ghrelin surges. When the eating window opens on a system flooded with hunger chemistry, control doesn't just get harder. Biology takes over. The body is running exactly the software it was designed to run. 4. Years of restriction damage the one skill mindful eating depends on. Interoception: the ability to feel hunger and fullness accurately. Every rule followed in place of an internal signal trains us further from our own bodies. Mindful eating's job is to recalibrate the compass that dieting broke. 5. The neuroscience is direct. Mindful eating doesn't manage cravings from above. It changes the wiring below. Neuroimaging shows it physically quiets the brain's reward pathway and strengthens the circuits where deliberate choice lives. The food noise gets quieter because the brain has changed its response to the signal. 6. Every conversation about fat loss eventually arrives at the same question. Not which protocol to follow. Who do you want to be in relationship with food? The thermostat is always an identity question. Mindful eating works at that level. Everything else reaches around it. Ready to go deeper? If this one landed, the next step isn't another protocol. It's a different target entirely. Escape the Willpower Trap is where we do this work, changing the relationship with food, not the meal schedule. The quiet mind is waiting. The door is open: https://news.weightlossmindset.co/subscribe
What if one of the most important health crises affecting men today wasn't being caused by aging, but by the environment we live in? In this eye-opening solo episode, Darin Olien investigates the alarming decline in testosterone levels, fertility, and reproductive health among men worldwide. Drawing on decades of research, epidemiological studies, environmental science, endocrinology, and public health data, Darin examines the growing evidence connecting endocrine-disrupting chemicals, microplastics, sleep deprivation, chronic stress, poor lifestyle habits, and environmental toxins to declining testosterone levels across generations. From BPA, phthalates, atrazine, PFAS, and microplastics to sleep quality, circadian rhythms, cholesterol metabolism, cortisol regulation, and natural testosterone-supporting strategies, this episode explores what may be one of the most underreported public health issues of our time—and what men can do to take control of their health today. What You'll Learn Why testosterone levels have been declining for decades The startling research on global sperm count decline How endocrine-disrupting chemicals interfere with hormone production Why BPA and phthalates may disrupt testosterone synthesis The role of atrazine, PFAS, and environmental toxins How chronic stress diverts resources away from testosterone production Why sleep may be the most important testosterone intervention The connection between cholesterol and hormone production How microplastics are being found throughout the human body The surprising relationship between statins and testosterone levels Natural lifestyle strategies that support healthy hormone production Practical steps to reduce environmental exposure and improve health Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Fatty15 and cellular health 00:04:17 – The testosterone collapse explained 00:04:51 – Testosterone levels have been declining for decades 00:06:03 – Global sperm count decline and accelerating trends 00:07:02 – Why treating symptoms misses the root cause 00:07:27 – The hidden public health crisis 00:08:03 – Why low testosterone isn't just about aging 00:09:12 – Why hormone health affects longevity 00:09:53 – Low testosterone and increased mortality risk 00:10:35 – Testosterone's role in metabolism and cardiovascular health 00:11:27 – Endocrine-disrupting chemicals and hormone disruption 00:12:44 – BPA and its effects on testosterone production 00:13:59 – Phthalates and their impact on hormone pathways 00:16:00 – Glyphosate, atrazine, and pesticide exposure 00:17:07 – PFAS and reproductive health concerns 00:17:55 – Environmental toxins and population-wide effects 00:18:11 – Sponsor: Shakeology 00:20:02 – Cholesterol and hormone production 00:20:53 – Chronic stress and cortisol dominance 00:21:45 – Actionable solutions begin 00:21:56 – Why sleep is essential for testosterone production 00:23:07 – How sleep deprivation rapidly lowers testosterone 00:23:21 – Light pollution and circadian disruption 00:23:41 – Foods and nutrients needed for hormone health 00:24:23 – Microplastics and testicular tissue 00:24:53 – Statins and unintended hormonal consequences 00:25:39 – A practical testosterone sovereignty protocol 00:25:48 – Water filtration and reducing toxic exposure 00:26:13 – Eliminating plastics and fragrance chemicals 00:26:35 – Why organic food matters 00:26:45 – Sunlight and vitamin D 00:27:05 – Magnesium, omega-3s, and iodine 00:27:26 – Pine pollen and natural androgen support 00:28:01 – Tongkat Ali and ashwagandha 00:28:48 – Strength training and lifestyle interventions 00:29:10 – Habits that naturally support testosterone 00:29:27 – Darin's approach to healthy aging 00:29:37 – Plants, herbs, and common sense 00:29:51 – Reclaiming your health and sovereignty 00:30:00 – Final thoughts and closing message Thank You to Our Sponsors Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Shakeology: Get 15% off with code DARINO1BODI at Shakeology.com. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The testosterone crisis may be about far more than aging. It may be a reflection of the modern environment itself—one increasingly saturated with endocrine-disrupting chemicals, chronic stress, poor sleep, circadian disruption, and toxic exposures. While many of these forces feel outside our control, the encouraging reality is that many of the most powerful interventions remain accessible: improving sleep, reducing toxic load, eating whole foods, getting sunlight, managing stress, exercising regularly, and reclaiming responsibility for our health. The goal isn't fear. The goal is awareness—and action." Bibliography/Sources: The Decline — Primary Research Levine, H., Jørgensen, N., Martino-Andrade, A., et al. (2022). Temporal trends in sperm count: A systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Human Reproduction Update, 29(2), 157–176. https://doi.org/10.1093/humupd/dmac035 Lokeshwar, S. D., Patel, P., Fantus, R. J., et al. (2021). Decline in testosterone levels in men aged 15–40: Results from the National Health and Nutrition Examination Survey (NHANES), 1999–2016. World Journal of Urology, 39(2), 447–452. https://doi.org/10.1007/s00345-020-03227-1 Spital Clinic. (2026, March). Declining testosterone levels by generation. https://www.spitalclinic.com Travison, T. G., Araujo, A. B., O'Donnell, A. B., Kupelian, V., & McKinlay, J. B. (2007). A population-level decline in serum testosterone levels in American men. The Journal of Clinical Endocrinology & Metabolism, 92(1), 196–202. https://doi.org/10.1210/jc.2006-1375 Low Testosterone — Mortality & Disease Risk Muraleedharan, V., Marsh, H., Kapoor, D., Channer, K. S., & Jones, T. H. (2013). Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. European Journal of Endocrinology, 169(6), 725–733. https://doi.org/10.1530/EJE-13-0321 Shores, M. M., et al. (2006). Low testosterone associated with increased all-cause and cardiovascular mortality. Archives of Internal Medicine, 166(15), 1660–1665. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/410754 Yeap, B. B., Marriott, R. J., Dwivedi, G., et al. (2024). Associations of testosterone and related hormones with all-cause and cardiovascular mortality and incident cardiovascular disease in men. Annals of Internal Medicine. https://doi.org/10.7326/M23-2781 Endocrine Disrupting Chemicals Associations between endocrine-disrupting chemical exposure and fertility outcomes: A decade of human epidemiological evidence. (2024). PubMed Central (PMC12299029). https://pmc.ncbi.nlm.nih.gov/articles/PMC12299029/ Hayes, T. B., Haston, K., Tsui, M., et al. (2002). Herbicides: Feminization of male frogs in the wild. Nature, 419, 895–896. https://doi.org/10.1038/419895a Mechanisms of testicular disruption from exposure to BPA and phthalates. (2020). Journal of Clinical Medicine, 9(2), 471. https://pmc.ncbi.nlm.nih.gov/articles/PMC7074154/ Meeker, J. D., Calafat, A. M., & Hauser, R. (2014). Urinary phthalate metabolites and their biotransformation products: Predictors and temporal variability among men and women. Journal of Exposure Science & Environmental Epidemiology. https://www.sciencedaily.com/releases/2014/08/140814124330.htm Zhao, Q., et al. (2023). Male reproductive toxicity of microplastics: Head and tail of the sperm. Science of the Total Environment, 872, 162181. https://doi.org/10.1016/j.scitotenv.2023.162181 Zhong, B., et al. (2024). Mixed EDC exposure associated with reductions in testosterone and free androgen index. Scientific Reports. https://doi.org/10.1038/s41598-024-76972-z Cortisol, Stress & the HPG Axis Bielohuby, M., et al. (2012). Swiss military cadets prolonged stress study. Psychoneuroendocrinology. Preprints.org. (2025). Sleep deprivation: A modifiable cause. https://doi.org/10.20944/preprints202505.0580.v1 SiPhox Health. (n.d.). Summary of Journal of Clinical Endocrinology & Metabolism data. https://www.siphoxhealth.com Viau, V. (2002). Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axes. Journal of Neuroendocrinology, 14(6), 506–513. https://doi.org/10.1046/j.1365-2826.2002.00798.x Sleep & Testosterone Leproult, R., & Van Cauter, E. (2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA, 305(21), 2173–2174. https://jamanetwork.com/journals/jama/fullarticle/1029127 Reiter, R. J., et al. (2021). Melatonin and male reproductive health: Relationship to oxidative stress, mitochondrial function, and Leydig cell protection. Endocrine. Tan, D. X., Hardeland, R., Manchester, L. C., et al. (2023). Melatonin as a pleiotropic antioxidant hormone. Journal of Pineal Research. Nutrition — Zinc, Vitamin D, Cholesterol Corona, G., et al. (2010). Statin therapy and testosterone levels in men: A systematic review. The Journal of Sexual Medicine. Daniell, H. W. (2002). Hypogonadism in men consuming sustained-action oral opioids. The Journal of Pain, 3(5), 377–384. https://doi.org/10.1054/jpai.2002.126790 Pilz, S., Frisch, S., Koertke, H., et al. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(3), 223–225. https://doi.org/10.1055/s-0030-1269854 Prasad, A. S., Mantzoros, C. S., Beck, F. W., Hess, J. W., & Brewer, G. J. (1996). Zinc status and serum testosterone levels of healthy adults. Nutrition, 12(5), 344–348. https://doi.org/10.1016/S0899-9007(96)80058-X Natural Testosterone Support — Botanical Evidence Pine pollen impacts testosterone-related symptoms in men. (2024). ACMCR Case Reports, 14(5), 1–9. Chinnappan, S. M., George, A., et al. (2021). Effect of Eurycoma longifolia standardised extract Physta on testosterone levels in ageing males: A randomised, double-blind, placebo-controlled multicentre study. Food & Nutrition Research, 65. https://doi.org/10.29219/fnr.v65.5647 Lazarev, A., & Bezuglov, E. (2021). Testosterone boosters intake in athletes: Current evidence and further directions. Endocrines, 2(2), 109–120. https://doi.org/10.3390/endocrines2020011 Leisegang, K., et al. (2022). Eurycoma longifolia (Tongkat Ali) improves serum total testosterone in men. Food & Nutrition Research. https://pubmed.ncbi.nlm.nih.gov/36013514/ Leitão, A. E., et al. (2021). 6-month double-blind RCT: Eurycoma longifolia 200mg + concurrent training. Maturitas. https://doi.org/10.1016/j.maturitas.2020.10.005 Lopresti, A. L., Smith, S. J., et al. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha extract. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186 Pandit, S., Biswas, S., Jana, U., De, R. K., Mukhopadhyay, S. C., & Biswas, T. K. (2016). Clinical evaluation of purified shilajit on testosterone levels in healthy volunteers. Andrologia, 48(5), 570–575. https://doi.org/10.1111/and.12482 Saden-Krehula, M., Tajic, M., & Kolbah, D. (1971). Testosterone, epitestosterone and androstenedione in the pollen of Scotch pine Pinus sylvestris L. Experientia, 27(1), 108–109. https://doi.org/10.1007/BF02137731 Wankhede, S., Langade, D., Joshi, K., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial. Journal of the International Society of Sports Nutrition, 12, 43. https://doi.org/10.1186/s12970-015-0104-9
In his weekly clinical update, Daniel Griffin and Vincent Racaniello express concern about vaccine policy and ACIP, scaling back of the CDC's role in global public health, shingles vaccine and dementia, new screwworm cases, the Ebola outbreak in the Congo and Uganda and where the hantavirus outbreak began, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, Virgina outbreak of measles, how to access and pay for Paxlovid, how more people were negatively impacted by influenza than COVID, discontinuing contact precautions for COVID, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Today we filed a motion asking the First Circuit to expedite our appeal of the district court's order in the AAP lawsuit that left ACIP—the nation's vaccine advisory committee—without a quorum (X) CDC advisers drop decades-old universal hepatitis B birth dose recommendation, suggest blood testing after 1 dose (CIDRAP) HHS asks for expedited appeal of court ruling on US vaccine policy (CIDRAP) New Plan Scales Back C.D.C.'s Work on Diseases Abroad (NY Times) Zoster Vaccination and Dementia: Interpreting the Signal and Testing the Mechanisms (CID) Safety and Immunogenicity of 1 or 2 Additional Doses of the Adjuvanted Recombinant Zoster Vaccine Administered 5–6 Years After Primary Vaccination in Adults ≥50 Years (OFID) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Head-to-head comparison suggests flu was much more likely to lead to hospitalization than COVID last winter (CIDRAP) FDA Issues Emergency Use Authorization for Generic Over-the-Counter Drug to Treat New World Screwworm in Dogs and Cats (FDA) Fact Sheet: Emergency Use Authorization of Nitenpyram Tablets (nitenpyram) for New World Screwworm (NWS) (FDA) Ebola dashboard (ebola.fyi) EBOLA:The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Big Ebola outbreak puts spotlight on little known virus (Science) Ebola outbreak spreads to crowded displacement camp in Congo (Reuters) Ebola outbreak in DR Congo expands into large displacement camp (CIDRAP) Congo Ebola outbreak may be worst ever, Africa CDC says (Reuters) Advocacy groups are urging the release of the monoclonal antibody MBP134 and any other requested investigational therapeutics (Citizen.org) Hantavirus dashboard (Hantavirus.up Hantavirus on board with Prof. Vincent Racaniello (microbeTV) How did the cruise ship hantavirus outbreak start? (Science) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard( South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) UtahMeasles Dashboard (Utah Department of Health and Human Services) US measles cases continue to climb, especially in Virginia(CIDRAP) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Anguished Parents, Crying Doctors: Life Amid Utah's Measles Outbreak (Wired) Characteristics of Patients Hospitalized with Measles During an Outbreak — West Texas, January–March 2025 (CDC:MMWR) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) USrespiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Weekly surveillance report: clift notes (CDC FluView) Influenza Vaccine and Associated Infection and Death in California, 2024 to 2025 (JAMA Network OPEN) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Seasonal influenza versus COVID-19 hospitalisation risk during the 2025–26 influenza season (LANCET: Infectious Diseases) Discontinuingcontact precautions for COVID-19: the science says its time (Infection Control and Hospital Epidemiology) 2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans (JAMA Internal Medicine) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) UnderstandingCoverageOptions (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia University Irving Medical Center) The answers: Long COVID Reaching out to US house representative Letters read on TWiV 1332 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
In this episode, we explore the surprisingly thin evidence base behind antipsychotic switching — one of psychiatry's most common clinical maneuvers. Dr. Oliver Freudenreich breaks down a landmark systematic review and shares six practical tips to help clinicians switch antipsychotics safely and confidently. Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CMEs: Quick Take Vol. 82 Switching Oral Antipsychotics: Six Strategies and Tips
This podcast explores the evolving landscape of GLP-1 therapies, highlighting new formulations, emerging clinical uses and future directions of metabolic care. The episode reviews access and affordability while also providing a clear understanding of where GLP-1 therapy is headed in this rapidly changing field. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.
If there is a difficult conversation you've been avoiding, this episode is for you.I know most clinicians do not avoid hard conversations because they don't care. We avoid them because we are not sure how to define the problem, connect it to a standard, and communicate it in a way that actually leads to change.In this episode, I walk you through the five-step framework I use when addressing supervisee performance concerns, professional behavior issues, and situations where expectations have become unclear. We talk about why so many supervisors get stuck in self-doubt, how imposter syndrome shows up during leadership moments, and why avoiding a conversation often creates more damage than having it.I also share examples from my own supervision experience, including mistakes I made early in my career and how those experiences helped me develop a clearer process for addressing concerns while protecting the supervisory relationship.This framework applies whether you supervise today, plan to supervise in the future, or simply want to strengthen your clinical leadership skills.In this episode, you'll learn: How to define supervision concerns using observable behaviors instead of labels Why every difficult conversation should connect back to a standard, contract, or ethical guideline How documentation and follow-up create accountability and growth What imposter syndrome sounds like when supervisors avoid necessary conversationsLeadership is not about avoiding discomfort. It is about addressing concerns clearly, ethically, and consistently. When you have a process, difficult conversations become less intimidating and far more effective.Want to learn more? Check out this month's free resource from Kate Walker Training. If this episode raised questions about supervision, documentation, remediation, or how to hold supervisees accountable while preserving the relationship, those are exactly the conversations we continue inside the Step It Up Membership. Clinical leadership is a skill, and it's one you don't have to develop on your own.Get your step by step guide to private practice. Because you are too important to lose to not knowing the rules, going broke, burning out, and giving up. #counselorsdontquit.
Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. The industry continues to evolve, with significant scientific advancements, regulatory updates, and strategic business moves shaping the landscape. Let's delve into these developments, starting with some key insights from oncology. In the realm of oncology, minimal residual disease (MRD) is becoming increasingly pivotal. Tumor-informed MRD is being leveraged to design more intelligent trials and interpret early responses, aiding in navigating developmental risks more effectively. This approach was a focal point of discussions at the American Society of Clinical Oncology's annual meeting, where experts emphasized the need to translate precision oncology discoveries into patient care, aiming to surmount existing challenges. The focus on MRD in oncology could lead to earlier detection of treatment responses and personalized therapeutic approaches. Verastem Oncology recently revisited its strategy concerning its combination treatment of avutometinib plus defactinib for metastatic pancreatic cancer. While clinical trials produced moderate results, the company is now redirecting focus toward other promising candidates in its pipeline. Similarly, Novocure faced setbacks as its tumor-treating electric fields device did not achieve its primary endpoint in a Phase 3 glioblastoma trial. These outcomes highlight the persistent challenges in tackling aggressive brain cancers. On the regulatory front, Spero Therapeutics achieved a significant milestone with FDA approval for Utebzi to treat complicated urinary tract infections. This approval marks a turnaround from a previous rejection four years ago, facilitated through a partnership with GSK. Meanwhile, in Europe, Cinnagen secured approval for Zandoriah, a biosimilar of teriparatide, to treat osteoporosis in adults—a testament to their investment in infrastructure and manufacturing capabilities. The industry also sees growing interest in cell therapy automation, with companies like Cellares and Ori Biotech leading the charge. These advancements reflect an industry-wide push towards more efficient manufacturing processes for cell therapies. In metabolic health, Novo Nordisk's oral GLP-1 drug Wegovy has gained significant traction due to its brand familiarity among healthcare providers, crucial in its competition with Eli Lilly's Foundayo. Market trends reveal competitive dynamics within obesity treatments as Novo Nordisk's oral Wegovy outpaces Eli Lilly's offerings due to strong brand recognition. Biogen's acquisition of Raythera for $1 billion underscores its strategic intent to enhance its portfolio with promising preclinical immunology assets. Such acquisitions highlight broader industry strategies focusing on expanding pipelines through targeted investments. This move aligns with Biogen's focus on autoimmune diseases and enhances its preclinical portfolio. In business development news, LabGenius Therapeutics partnered with LG Chem to utilize AI and machine learning for designing multispecific antibodies targeting tumors. This collaboration highlights the growing importance of artificial intelligence in accelerating drug discovery processes within oncology. Clinical trials continue to yield promising results. F2G and Shionogi's antifungal small molecule olorofim demonstrated efficacy comparable to Ambisome in treating invasive aspergillosis—an advancement crucial for infectious diseases with limited treatment options. D&D Pharmatech's Zabopegdutide showed an impressive improvement rate in fibrosis during Phase 2 trials for metabolic dysfunction-associated steatohepatitis, emphasizing the potential of protein-based therapies in treating metabolic liver disorders. Corporate launches reflect strategic maneuvers aimed at advancing therapeutic developments. Innoviva introduced Nortiva Bio to focus on long-acting oral medicines using acquired platform technology from Lyndra Therapeutics—aiming to revolutionize women's health through sustained-release formulations. The financial landscape also shows active movement, exemplified by Kardigan's $400 million IPO aimed at progressing cardiovascular drugs into advanced trials. Alvotech's public offering signals a commitment to biosimilar medicines—a sector poised for growth due to rising demand for cost-effective biologic therapies. Overall, these developments reflect a robust innovation pipeline within the pharmaceutical and biotech industries as they strategically address complex diseases through novel therapies and technologies. As scientific progress accelerates alongside strategic corporate actions, these changes promise enhanced patient care outcomes through groundbreaking treatments that cater to unmet medical needs worldwide.Support the show
Soccer analyst Gord Smith on how the win over Qatar will help against the Swiss, Jonathan David answering his critics, and the tackle that broke Ismaël Koné's leg.
In this episode, Lera—our special Academy member—joins Debora and Rahul to unravel a fascinating case of a young man with neurological symptoms that takes an unexpected and incredible turn. Presented by Mark, this diagnostic journey will keep you guessing until the very end. Don't miss this compelling path to the final diagnosis! To join us… Read More »Episode 462 – The Clinical Unknown Series with Lera Novotnaia
Re-releasing a Dental A-Team favorite… Ladies and gents, he's back. Dr. Dave Moghadam is again on the podcast, this time to talk with Kiera about quarterly team calibration. While there's no silver bullet A-to-Z cookbook for how to operate a practice, an outline certainly helps. Dr. Moghadam shares his outline for setting up the ideal quarterly calibration meeting: Start with the why (review practice's mission, vision, and values) Align over treatment, planning, and diagnosis Review what makes your practice stand out To keep things exciting each quarter, Kiera and Dr. Moghadam also chat about ways to shake up the meeting. Episode resources: Subscribe to The Dental A-Team podcast Schedule a Practice Assessment Leave us a review Transcript: Kiera Dent (00:00) Hello, Dental A Team listeners. This is Kiera. And today we are bringing you something so special. I am so excited because this is one of our most popular episodes from the archives. Whether you're hearing this for the first time or catching it again, I am so excited because it's jam packed with a ton of takeaways that you can start using right now in your practice. We have released thousands, literally thousands of episodes. And I wanted to start bringing a few of these amazing episodes back for you. So I hope you enjoy. And as always, thanks for listening and I'll catch you next time. on the Dental A Team podcast. speaker-0 (00:32) and you guys, I am so jazzed to welcome back one of my favorite doctors, an office that we coach, and he just thinks outside the box. This man is brilliant. He's grown a ton. I'm so proud of him. We've worked with him for quite a while. So welcome back to the show, Dr. Dave Moghadam. How are you? speaker-1 (00:47) I'm doing wonderful Kiera. Thanks for having me. Super excited to be there. speaker-0 (00:50) my gosh, absolutely. Well, when we were doing our last podcast, you were somebody that I just admire. One, you're a doctor. So you give a different perspective than I do. Two, you're brilliant. And three, you've got lots of cool topics that I'm excited to share. So I am Jazz. When we were on our last podcast, you came up with a few more. Today you just came up with another one. Guys, I will tease that one out. It's not today's podcast, but we will do it again. It's gonna be I T F U. So I hope you guys are excited for that. I'm excited. speaker-1 (01:17) That's the the closest I think I can get you to swearing. speaker-0 (01:20) It is the closest. but today we're gonna kind of dive into team quarterly calibration, which Dave, I will say, is probably one of my top doctors that thinks in systems, but not just thinks, actually executes. And you see massive growth and evolvement of your team. You were one of the offices who literally called me during COVID and said, Kiera, I'm gonna train my hygienist. What do you have on hygiene training? And I was like, Who are you? Fantastic. We have our hygiene training course. Like, here you go. Try it out. We're beta testing right now anyway. But kind of let's take it away, Dave, on this team quarterly calibration because it's so needed. And I love that you've actually created a system around it that you've proven to be effective in your practices. speaker-1 (01:59) Yeah, for sure. So I actually I I got the idea from another office that you work with that's in up upstate New York. Wonderful, amazing doctor. Really, I mean, really, really just drives home that aspect of really just thinking outside the box, having a crazy drive and really just executing. Really has a wonderful team in place there. Let's be real. speaker-0 (02:20) He's far away. Dave, you know he's far away. And I'm gonna say this like out loud because I know exactly who you're talking about. And I actually mentioned this to another doctor I was talking to today, and I said, let's be real. He's far away, and I visit him four times a year. Like we're talking opposite coast from me. And I said, and I truthfully do it because this man I think is such a brilliant leader, and I selfishly go to coach them to learn from him. So agreed, like just massive kudos want to bring this on. And you were mentioning he had a word document. He's just brilliant and I'm so jazzed that you took some things that he did and spun it to your own. And I wanna point out, everybody listening, take what Dave's gonna share. He took it from somebody else. I don't think there's anything wrong in taking items, mimicking them, mirroring them, and recreating them for your practice. So please, please, please, like do exactly what Dave did. Take it and shout out to that office in New York. Thanks for paving the way for so many great ideas. speaker-1 (03:14) Yeah, I mean, absolutely. I think that's the best thing. I think when we all go ahead and, you know, take take ideas and expand on them and share them back and forth, you know, things really kind of get going. I'm always happy to, you know, help help out others in in the same way. But at the end of the day, I've tried to explain to people that I've shared, you know, a lot of my systems, my processes, my my things with is just because it's it good for me doesn't mean that it's gonna be good for you. You have to do the work, not because I want you to not, you know. reap the the rewards of this, but because it it has to fit for your office and it has there needs to be some some ownership, some authorship from from your team and how things work as well. So I mean taking the concepts and expanding on them and making your own is gonna be the key in, you know, anything that we're gonna talk about today or just in in general, really. speaker-0 (04:00) Totally agree. And Dave, you just drove home a really, really good point because I don't think that there actually is a plug and play. I don't think you go to the store, buy a system, come back to your practice and say, Okay, let's put it in, put the batteries in, read the instructions. I genuinely think, like you said, it's a concept, it's an idea that then needs to be transformed into your own practice. And I think so many offices get frustrated that they don't see momentum because they literally try to say, like, well, this is what Dave did. So take it, move it into my practice and hope that it goes on autopilot. But they don't realize the countless hours you put in to making this work for your practice. So I love, love, love. And I hope all you guys heard that because I'll give you guys systems all day long on this podcast. It's what we do. We come to your practices and do it. Bottom line is there's a reason we don't have an A to Z cookbook as a consulting company. I don't believe it works. I believe you have to customize it to your practice to get momentum. speaker-1 (04:49) You can have an you can have an outline because even even even with making this, I mean, spoiler alert, like I made this, but then you know, six months later, a year later, like, you know what? Like, we should probably do this like this. It's a never ending, it's a never ending thing. It's just the way that things go. And I don't mean that in a bad way. I mean it's it's one of those things as you you grow and you learn. And the other thing that we'll get to is as as your team becomes more comfortable and they start to go ahead and give their input about things, that's when it really kind of, you know, starts to hit its straw. speaker-0 (05:20) Right, right. I agree. So we've teased it up enough, guys. So we've got this awesome team quarterly calibration. So Dave, kinda take it away again, and like you said, this is this is as of today, but I promise you, give Dave six months to a year and it will look it will look different. It will be fine tuned again. so I'm excited. Take us away. speaker-1 (05:40) Yeah, so I I think the first thing is like ever every office, you know, in starting to create, you know, why you're there, what you're doing, all that stuff. In in one way or another, you sit down and you and you figure out your mission, your vision, your core values, like all these key concepts in, you know, any business. And that was something that we did really early on, as I was actually five, five years ago, probably right about now when this podcast is gonna air. first thing I did is I sat down and we kind of all talked together about what What are we going to do? Why are we going to do it? You know, why are we here? So kind of reviewing those key concepts. And we we kind of cycle through, you know, reviewing those things on a weekly basis, but it's a good time to kind of highlight that in the beginning. of like, well, why are we here? What are we actually trying to do? Why are we going to make the decisions that we make on a daily basis? So that's the first thing. The other thing is like, well, what are the practice philosophies? Like, how are we going to treat and plan? Why are we doing things in that way? You know, this kind of stems off of that. And then you know, we move towards, you know, in discussing things with patients, what's the way we're going to do that? You know, so the key concepts I always kind of bring out is, you know, what do we see? You know, what's going to happen if it's if it's not treated? What are the best options that, you know, you we can give somebody? And, you know, why is that better than other options? You know, so these are always the key points that I I want in the back of, you know, our team's mind when we we're talking about situations and things that we see. And then other than that, I mean, I think it's two other big, big topics here. You know, what conditions, you know, are we going to encounter? And you know, how are we going to discuss those things and what is treatment planning generally like? And then what makes our office special? You know, really highlighting those things, like talking about these concepts. So this is, even though it was only a few minutes that I just went through that, if we're going to really go through everything in detail here, I mean that's a it's it's a couple hours. and I mean, the point I'll I'll I'll get to here is, you know, maybe the first, second, third time, great, but at the end of the day, sometimes it becomes a lot. So you have to kinda eventually figure out ways, well, how are we going to mix things up? Because if you're lucky enough to continue to have the same team there for a long time, you're all gonna be sitting there twiddling your thumbs, being like, Okay, like I get it, but you know what's going on. speaker-0 (07:46) Yeah, no, you're exactly right. And I think that that's why a lot of people love us because we'll bring in and shake things up and add some excitement. Cause you're right, it can get monotonous and tedious. But that doesn't mean because it becomes monotonous and tedious that we shouldn't continue to do it. Just change how we're doing it, look for ways to innovate it, and make it even better. So if I broke that down, Dave, it sounds like we start with kind of the why. Why are we doing this? What are our core values? Let's assess that, make sure those are aligned because that's gonna be the the launch pad, if you will, to the next level. Then it sounds like it was treatment, planning, how we're diagnosing things, making sure that's all aligned. And then the third piece would be on what makes us special, what makes us different, what's our wow factor, if you will. And those are kind of the three points. And please feel free to add in any gaps that I left out because I don't know your outline. So I'm I'm learning right along with the listeners, right? speaker-1 (08:35) Yeah. So I mean that that's the basics of it. The one thing that's kind of like a little bit misleading is like with the treatment plan and stuff like that. Like what I've done is kind of gone and I've gone off of that that doctor's kind of like general template and added more is like condition by condition. You know, so maybe like 10, 15, you know, things that you wanna list out. And you don't have to you're never gonna hit everything. You know, so you want to kind of get, you know, 80% of what we're you know, what are gonna encounter on a daily basis? And I think the way to really think about this is the the concept that you guys really drive home very well is what would doctor do? Yep. That's kind of like this is like that on steroids. The problem is when you do that like this much, at a certain point it becomes kind of like hiring. So I think it's nice. We now we kind of quickly will go through some of this as a review, but I think a way that we could probably improve more is if let's say, you know, once a month or so I kind of just did a smattering of, you know, some examples like that to kind of just really freshen things up. And a lot of times, you know, some of these things are like, yeah, these are the cool things that we're doing. But a lot of the pictures, a lot of the things that I share in this section is kind of like, hey, we thought it was going be like this, but guess what? It's like a bomb went off. Because I think it's very hard for somebody who's not, you know, in the the trenches in a sense, with a lot of these situations to really understand the extent which is actually helpful. Cause rather than, you know, let's say in in the the hygiene room, like You know, when we're treatment planning, telling the patient, no problem, it's not going to be a big deal. We kind of say, you know, this is what it looks like in certain situations. We've seen things become like this, just you know, you know, so setting up that kind of worst case scenario, and that's like one of our and when we talk about like the philosophies that we talked about in the beginning, it's underpromise and over-delivered. Right. You know, we always want to talk about worst case scenario. We want to talk about the fact that, you know, in situations where we think that, you know, further treatment like a root canal may be necessary. But that's that's a discussion even before an appointment is scheduled. Mm-hmm. That all has to be there. You know, it's nice to to to be positive and everything, but it's not nice when you you do that and then it's a it's a mess later. speaker-0 (10:36) No, you're exactly right. And I, you know, my mind obviously went into system mode as you were talking. And I'm like, Dave, I got this great idea. take all your conditions and things that you look at, make them into twelve of them. Then every month on your quick check-in calibrations, you could have all twelve of those. So throughout the year you go through them and then each quarter you highlight maybe the three things you've gone over. That was my instant like, hey, this is how you could like keep it on a system on a regime. or bring case studies every quarter that that you then would take because they've already learned for three months, then six months and n nine months and twelve months. but I I'm curious and I want to dive into the kind of nitty gritty of it. How do you set up these quarterly calibrations? Because I'm hearing like we want to talk about it, like you mentioned, like this treatment planning. It should be a discussion. but I also have watched and I know myself, I can sit and listen all day long. But then when I'm asked to repeat or I'm asked to implement or I'm asked to talk about it, I go back to what I know. Even though I just heard it, I might catch one or two phrases. So do you role play it out? Is it more of a like C discussion and we all discuss how we're going to discuss like kind of walk me through what and do you do you block it out for a full day? Is this a one hour over lunch? Like, how does this kind of kind of look? I feel like I've got a general like outline of it, but then how do you actually execute on this? speaker-1 (11:57) Yeah, so we'll so we'll we'll block out a a a couple hours, two or three hours, depending on you know the situation. Well, we and I've tried you know a bunch of different ways as far as like a lot of the things that you mentioned. I think the things that are that are most effective and most effective in general, which you know I used to do more so in the beginning, not so much right now, is really just kind of randomly like calling on people and kind of being like, Okay, like let's like this is the situation, like let's kind of talk it out. And it's a little uncomfortable at first, but it kind of, you know. makes it really gets somebody involved in it. Now what I would do early on is kind of like pretend like you're you're the doctor. But what I've done to kind of mix it up a lot of times is kind of getting a couple of people involved where it's what it's fine. It's whatever their role is in the office, let's say in this situation, you know, sometimes we'll do that or we'll mix it up, but we try and go through the the different stages of let's say, you know, we found this as an emergency patient, let's say. Yep. So you're gonna be the assistant, you're gonna be the doctor, and then you're gonna be the the front office person. You know what I'm saying? And kinda, you know, go through that step by step. So we can kind of work on the the workflow, like you know, the the basically the the timeline a patient would go would go through the office and everything in in that. So that is work well. Honestly, like as as I've done this longer and longer, sometimes it's just kinda like It's like going through the motions and it's just kind of like, okay, you guys know this, let's go through this. And that really hasn't been so effective. So sometimes I'll kind of take a pause and I'll just even, you know, hop on you know, open dental and you know, think of like, okay, who have I seen like lately where this isn't just open up like the x-rays and kind of do examples like that. I think that's been a little bit more helpful. The hard thing is, I mean, it's you know, we're all busy. It takes a lot of time to try and go ahead and do all this stuff. But I think if I was able to get a little bit more regimented in in mixing it up. But for the purposes of, you know, everybody listening, I think if you get a good, you know, outline together, you get things together, you know, this will afford you, you know, the ability to do this at least a couple of times and still be really effective. I blew the first handful of times I did it, even though it's like the same kind of thing, it's helpful and you you mix in some other stuff, but then it becomes kind of stale after a while. So you want to make sure you're bringing new examples or shaking things up or, you know, just kinda everybody kind of knows like, okay, yeah, we're gonna calling you you randomly pay pay attention. speaker-0 (14:14) Right. No, I love that. And it's funny that you said that because that's actually my trick in offices. People are always impressed that Kiera Dent can learn names very quickly in a practice. And I'm like, guys, the bottom line is the only reason, not the only, but one of the main driving reasons I learn names as soon as I go into a practice is one, people tend to like me a lot more if I remember their name. Two, I believe that if I'm gonna ask them to do something, I should at least know their name. And three is when I get to team meeting, you better believe I'm going to impress everyone and dazzle that I know your whole names. But then I'm going to randomly call on every person and they're like, she now knows my name. So I think it's really wise. I was also thinking, Dave, it's fun to to hear your ideas and then also flip into consultant care mode too. And I'm like, gosh, like let's just take this and expand on it. some fun things for that excitement that making sure everyone's on their toes is you can actually like have them draw straws. So like here's the case study, everybody draws straws, and it's a doctor, it's a hygienist, it's a treatment coordinator and an assistant. So they all have to draw straws and so it will if there's a natural excitement and terror and adrenaline rush real quick of here's the scenario, we're gonna role play this all the way through, draw straws of who's going to be who on this scenario. So then it's a constant shakeup. I also love the surprise and delight of asking people on the fly. But I really also love like and I was thinking like some way you could make this pretty simple for you quarterly is if you know that there's a a patient that that you're working on that you're like, this would be a great example. Maybe have your assistant mark that appointment in red or something. So that way you are pulling those constantly, which I'm sure you're doing, but thinking of offices of like, how could you be building this up for the next month or two? Just highlight some appointments, bring those to the table, or I'll be honest, I just did a what would doctor do with a a practice the other day. ironically it's actually the same office we were talking about earlier. Funny, funny coincidence there. But I just pulled up some FMXs on Google. Reason I did that was because sometimes if we know the patient, people get weird and they say, but that was Kiera and she's got a funny bite. And they have a thousand excuses versus just a FMX or just intraoral pictures maybe can help them see it. So Dave, it sounds like you guys I I love also hearing it's two to three hours, so that's helpful to know. Probably a couple case studies. Love the idea of different people role playing out different parts of that procedure. And I will say speaker-1 (16:34) Remember the so we didn't do straws when you kind of taught us this concept. Do you remember what we did? speaker-0 (16:40) I I think I just like put like name tags on people. I don't I don't remember exactly speaker-1 (16:45) So you got you ran out to what was it? Like I don't know, Michaels like some kind of Yeah. So we did that we did that one time too. I found them on Amazon and I got just to just to kind of mix things up. we basically got snowballs and you know, you people would kind of toss to the next person in the the line of the the patient experience. Yeah. Sometimes you just gotta do stuff like that to to to mix it up because otherwise, you know. speaker-0 (16:51) Was it the snowballs? Yes. Yeah, right. speaker-1 (17:13) To sit there for more than like half an hour, yeah, everybody's either gonna fall asleep or you know, bang their heads against the wall. speaker-0 (17:20) And I also think it's important, like another way I remember when I was in practice as an office manager, I got real sick of having to create all these because it like you said, it's a lot of time. But also if I'm always the teacher, how can I test my team's knowledge base? So also flipping the role and having some of them come of like, hey, here's here is the the piece of the treatment plan that we want to go through. So maybe it's root canals, maybe it's crowns, maybe it's implants, maybe it's on period. And have somebody come with how they explain it to to also double check their knowledge base. So like set them up. Like you're gonna be presenting on this part, you're gonna be teaching this part. I think is also a really fun way to shake it up. But those snowballs, that was funny. It just happened to be what we found at the store. But guys, if you ever want a snowball that actually feels like a snowball, they're pretty it was actually pretty fun. I I do remember that actually. speaker-1 (18:10) Pretty good. The ones that I found, not not so great. speaker-0 (18:12) I think I actually found them, if you wanna know. Go scope in in Christmas time, holiday time. I think it was like Walgreens or like I think that that 'cause I had to just run to the store real fast and I was like, these look great. but I love that, Dave. I love that you're getting your team to I think the big piece that I'm hoping offices are taking away from this is there's consistency in calibration. And you have a set time. So every quarter you know you're going to calibrate on some topic. We've got the why, why are we doing this? We've got the whole treatment plan and the procedures that we do in the practice, role-playing that out from start to finish. And then also you're doing the what makes us special. I really think that that cadence is brilliant. Even though it might feel routine and mundane, I might guess what working out is routine and mundane. But the long term effects of it when done consistently are health. and wealth and growth and drive. And so yes, you've got to shake it up. Everybody gets into that workout like suck and it just becomes very boring and you don't want to go work out anymore. So you shake it up, you come up with new routines, you find different trainers, you find different ways to do it. But at the end of the day, you're still working out. Just like here at the end of the day, you're still calibrating. You're still training. So how does your team feel about this, Dave? Like do they, do they look forward to it? Do they say like, calibration? Like how does it tend to go? That's my first question, then I've got a follow up to that one. speaker-1 (19:32) Yeah, I don't know. I think I think it's hard to say. I think it's it's it's a mixed bag in a sense. You know, some people have been with me for a really know a a lot at times with with stuff like that. I think it's nice to to kind of you know break up the schedule a little bit though because a lot of you know we do have our our weekly meetings, but still, you know, they're they're pretty short now. you know, given that we're not like we used to like eat while we were doing it. Now we kind of you know break that up, you know, based on our our protocols and everything like that. So it's like the shorter meetings. But it's nice to have a little bit more time in my mind then. but the other thing too that I that I wanted to to mention is I think the way that I that look at things is is a is a little bit different now. So I think it makes it a little bit less in intimidating. I think when I kind of first started out with this, it was very much like, this is the script, like you gotta say it exactly like this. And I realized that that's insane, for lack of a better terms, because really at the at the end of the day, like the important thing in my mind is like the the the key concepts are there, that the points are coming across the right way, but it has to sound like Pira. Right. You know what I'm saying? It has to sound like Dave. It has to sound like like an actual person. Like if it sounds like it just like a script, that like that defeats the purpose. The point of kind of us doing that is to have some uniformity in the concepts that are that are coming about. And so it builds trust with the patients. But if something sounds phony, that's the opposite of it. So I've kind of gotten away from a little bit more of like you need to say this exact word like this to kind of like, you know, these these are like the concepts. And if somebody says things in like a way where it doesn't kind of, you know, do that, it's kind of like, hey, that that's great. Maybe, you know, this is like the point we're trying to get across, you know, next time try it like like this a little bit. but you know you you'd be surprised, just like with a lot of this stuff, you know, sometimes, you know, it really comes across super well the way somebody says something and it's completely Unlike what we have written down, but it's the same idea. It just sounds like them. speaker-0 (21:26) Totally. And I'm so glad you brought that up because again, I'm gonna tie back to why I don't believe in an A to Z cookbook. I believe in systems and processes, but I also believe in in change. Because yesterday I was interviewing a new consultant for Dental A Team and on our collection call protocol, she almost had the exact same style that we did. But she literally said, we we do a kind call. So we call the patient in a kind way. And I was like, my gosh, that's brilliant, because it just gave this whole new feel. To a collections call versus like, I'm calling to collect money, and she called it a kind call. So to your point, you can actually find better verbiages, better ways when people do it their own way. But also don't be afraid to tell people if it comes across different because we don't hear ourselves. Dave, you're hearing me. I I can think and assume of how it's landing, but you're the one who's ultimately experiencing my words coming out. And so giving people feedback, some some some I giggle because I've got some team members and like Kiera, I said it just like you, and I'm like, No. What I said was this. What you said is like that they're stupid and they're incompetent. Like that's how it came across. But they don't realize it. So I've even had certain team members record themselves. and then in a loving way, a very safe space where it's not judgmental, like playing it back. So sometimes even one on one, because that way they can actually hear themselves. So maybe even after calibration, you could spice it up this time, Dave, if you want. have them role play these things and then have each person at least record themselves one time. you can have voice memos on your phone and have them actually listen back to see how it sounds because oftentimes like Dave, you and I actually chatted about how it sounded when you heard your podcast played back. You were like, I sound a lot different. I said, for my first like hundred and fifty, two hundred podcasts, I felt awkward. I still feel awkward, but it's becoming more normal. But we don't hear ourselves as much. So I think like that's also a piece to it of like Giving people that autonomy, also some things of having them record themselves, I think can help because then it also helps show knowledge base. And selfishly, I'm also always thinking of systems that actually create a training bank for future employees because you've actually got great verbiage, great examples that you can plug in under those certain topics that future hires could actually hear. You could create a really awesome training bank that way as well. speaker-1 (23:42) Yeah, I know for sure. That's one speaker-0 (23:43) So fun. Dave, I love it. So guys, I would say try it out. Try Dave's model. but I I'm gonna ask real quick, give us like a quick synopsis of like going through the why. Like we dove a lot into the treatment, how to have the role play, all of that. How like what's that why part? Like, does that is it just like a quick quick synopsis of you kind of reinstating the vision, the core values, reminding people why we're here. speaker-1 (24:05) Let me see. Hold on. Okay. So as far as as the why, I mean, we talked about mission, vision, core values, and we get to the philosophies of the practice. So the first thing is, you know, I we want to break down like what's what's our mission? So in our in our office, our mission is to exceed our patients' expectations. So, you know, what we've kind of talked about, well, what does that mean? You know, like how are we going to do that? We want to provide. compassionate and practical dental care. That's the second part. So like what does that mean to everybody? We want to provide outstanding customer service. So once again, like, you know, what does that mean? How do we interact? Are we providing information up front? Are we staying on time and respecting people's time? What many amenities we're providing, you know, how are we doing follow-up? You know, all these things. And a lot of this is like, you know, we have it written out, but it's a little bit more of a discussion. And then the other thing too, our the last part of our our mission at our office is remaining at the forefront Clinical advancement. So that's one of those things where when we first made this up, that was a big lie. I mean, everything was like analog paper, whatever. But you know, the then about, you know, a few months in, I got the itch and decided to to make some questionable financial decisions and just you know, go all in on everything because that's the way that I wanted to practice. So speaker-0 (25:23) Yeah. I I actually love that you broke that down. I love that you because sometimes as leaders when we build these visions, what we're envisioning is different than what our team actually does. So I love that you break it down like what does excellent customer service actually look like, feel like, what's the experience? Because then it becomes more tangible versus just words on a paper. speaker-1 (25:42) Yeah. So that's that's the first chunk. The second chunk was what we talked about underpromise and overdeliver. You know, I think that's that's a big part of it. The third thing is what we kind of talked about of like, you know, how uniformity, you know, builds and maintains trust. And so there's that fine line of like, yeah, we want it to sound similar, but also not like it's cookie cutter and bake. Right. And then, you know, a couple other things. Like, I think pictures really helps or you know, pictures worth a thousand words. We want to take good pictures of what we see so we can help explain something really well. And then the last chunk really is, you know, there are different types of of treatment. So there's stuff that's, you know, very important, more emergent, there's stuff that's preventative. And then, you know, the more elective, you know, cosmetic category of things. So we kind of talk about that. And that helps us, you know, figure out how do we want to, you know, prioritize everything. Sure. So that that's that's the the first big thing. And we dive into all that, you know, before we go into like the well how speaker-0 (26:39) Yes. Which I actually think is really important. I'm I'm big on sequence matters and I love that you first go through who are we as a practice. Let's kind of give some tangibles on it because that actually can spur people to think differently of how they would explain treatment or explain how they're gonna talk to a patient on certain things, which I really, really love that you did that. So now looping all the way to the end, Dave, you said you also talk about what makes us special. So what does that look like on this calibration piece for you? speaker-1 (27:05) So so basically this was another exercise we did at at some point. It was not one of the I didn't feel like if I just kind of sat there and I told people like, yeah, like this is why we're great, like that's that would be a big waste. Yeah. So I really we kind of we kind of sat down there and I said, like, let's just like get into it and you know, just call on everybody and say, Well, what do you think makes us stand out? You know, and we kind of just went through and and kind of really, you know. speaker-0 (27:18) Sure. speaker-1 (27:31) put together well, you know, what r what really sets us apart is as as an office. What are the things that we we try and do, you know? And as aside from that, even just some of the the basic stuff that a lot of offices have, even, but we want to make sure that we we're, you know, mentioning like, you know, like membership plan in in your office. Or if you do anything like, you know, like we do something that a lot of people do, like a whitening for life thing where it's basically they pay once and as long as they're coming regularly, you know, here you go. Right. You know, stuff like that. Just kind of like little things that, you know, patients may may ask anybody in the office and be yeah, I don't know what that is. Like that that would be very like that would be not good. speaker-0 (28:07) Yeah, absolutely. Well, because it's one of those things it's always funny. Offices, I I giggle a lot when offices tell me, Yeah, Kiera, I don't know what to do. Our patients, like, we do Invisalign in our practice, but they're still going to someone else. And I'm like, Because your patient doesn't know. Like, if they don't know all these things that you guys do, they will go somewhere else. They think you do their cleanings and you do their fillings. They don't realize that you do implants and ortho and sedation and Botox and all these other things. So I love that you constantly remind your team of what makes your office special because in doing so, that's then what they're going to translate to the patients. It's like, I I heard a great quote that said, repetition is the mother of skill. And I love that because we can talk about it one time, but if we're constantly repeating it, like why do we get so good at our morning routines? Well, because we repeat it every single day, to where it's it's second nature for us. We don't even have to think about it. So I really love that you You dive through the whole practice in a quick two to three hour thing. I love that it doesn't take all day. I love that it breaks out and shakes it up pre-scheduled out because this calibration is paramount. And I'm like, shoot, Dave, I'm like, I'm gonna go back and listen to this podcast. I'm gonna write these things down because I was thinking of consultant calibration. I have one once a month, but we don't go through the nitty-gritties of everything as consultant teams. And I've been watching as I've been doing client check-ins, that each consultant kind of has their own variance from office to office. If we could start to bring those in, hear what the other people are saying, how they're saying it, similar to doctors, if doctors could hear how different doctors are diagnosing different ways that they're explaining treatment, it helps elevate your entire practice and patient experience. And I think at the end of the day, that's what this ultimately is all about. Because if your patient experience is awesome, coming from an awesome team experience, the whole practice is just going to elevate and everyone's going to feel much happier, less stressed and all around great. Cool. speaker-1 (29:56) Yeah. So I you know, all this stuff is is helpful. I mean the the the take home message is if it can't it can't get stale. So it always requires time and effort to to try and mix it up. And that's always hard to be able to do. But you know, you you you do what you can and and really at the end of the day, I mean, you know, the more you can do with this stuff, the better. The other thing that you were you were talking about, how our patients don't really know what we do and everything like that. I mean, I can't I can't preach that enough. I mean, I think there are things that we can do way better to do that. simple thing that we did is we for a long time had like spear education videos looping in our waiting area. and it just really opened my eyes to the fact like sometimes like patient would come in and be like, I saw that video about that. Let's do that. my god, like this is like this is amazing, you know. So what we're what I'm working on right now is We try and put together basically like a little little slideshow in the background that part of it will be kind of things as far as you know, some of the clinical things that we do. Part of it'll be like, you know, getting to know team members better. So like little fun facts, things like that, you know, other things that just like you know, somebody may see in the background and find interesting, you know, kind of like a little subliminal in a sense, but we want to try and find a balance where it's not like so in your face. But the important thing there is really. People see this and they may not necessarily, you know, need the, you know, the the treatment or have the conditions that they see on the screen. But, you know, husband, wife, you know, mother, daughter, you know, who knows? And they may say, Hey, you know what? I saw this at at you know, my dentist, and the way that they do this looks pretty amazing. I've never like seen or heard of anything like that when they, you know, it seems like it was so much more involved. So that's that's a little project we have working on. And it's a little project that I personally am not dealing with, which I'm very, very happy about. So we're slowly, slowly getting everybody to help. speaker-0 (31:48) That's awesome. Well, and like you said, I think it's just an awareness piece. I think the more your patients can see it because the guys, I don't I don't need implants. Thankfully. my teeth are really straight. I hate my ding dang lateral number ten. If somebody wants to, you know, take me on as a patient, it just needs a quick rotation. That's all I need. but nobody ever asks me about it. But the And Dave, I'm sure on Zoom right now is like looking in, like, here, let me see your tooth. but the bottom line is like it's an awareness piece, just because I don't need it as a patient. I am connected to a lot of friends and family. So if I hear it at work or I hear it with my family and they're like, I need somebody to do ortho. I'm like, my dentist does that. So again, it's just an awareness piece for your patients. So, Dave, so many pieces you pulled in here. I love going through the why, actually going through the pieces of your practice. Then going into the tangibles of clinical, having case studies, examples, having people role play it out on different positions, and then going into what makes us special and reminding our practice of the things that we do offer. So it's a constant awareness and I love that you have this on a quarterly cadence. I think for all offices, I don't care how you do this, if it's once a year, if it's every four every three months, so four times a year, if you do it twice a year at retreats. I don't care, but I would strongly suggest each of you at least try to get this in. We're ending the year out. So I would say At least w at a minimum one calibration. I would strongly suggest that four because again, repetition is the mother of skill that can really help out. So Dave, as always, brilliant podcast. Love learning from you. Love hearing the great things you're doing. It's been fun to watch you evolve as as a leader and as an owner and as a clinician over the years that I've known you. So thank you again for your time today. It was it was just awesome. I loved it. Kiera Dent (33:24) Dental A Team listeners, I hope you loved revisiting this episode as much as I did. I hope that you found the nuggets, the pearls. You can see why we re-released this one because I truly want you to take away the best of the best of the best of the best. This episode truly hopefully sparked some new excitement, gave you some new ideas. I know sometimes when I go back and I look back on things that I've learned in the past, I'm able to re-implement because like that famous quote says, no man steps into the same river twice because neither he is the same man. nor is the river the same. You are not the same as you were before, nor is your practice the same as it was before. Different things, different ideas, same principles. And I really want to highlight and hopefully you took today that sometimes all we need to do is simplify and put into place or to refine things that we've already been doing really, really well. If you love this episode, don't keep it to yourself, share it with a colleague or leave us a review and help more practices find the Dental A Team podcast. As always, thanks for listening and I'll catch you next time on the Dental A Team podcast.
You've learned how to diagnose and treat patients.But nobody taught you how to diagnose and treat a business.In this special episode, I'm pulling back the curtain on the Clinician Entrepreneur Collective (CEC), my 8-week small business course designed specifically for clinicians. [https://tracybingaman.com/cec] If you've ever found yourself:Sitting on a business ideaCoaching people informally for freeSpeaking, consulting, or creating educational contentBuilding a side hustleDreaming about more flexibility, freedom, impact, or income diversification...this episode is for you.We'll discuss why so many clinician businesses stall, the common "disease processes" that kill small businesses, and how your existing clinical skills translate directly into entrepreneurship.Because medicine trained you to save lives.Now it's time to learn how to build something sustainable alongside it.Join the Clinician Entrepreneur Collective at https://tracybingaman.com/cec Our next cohort begins July 1, 2026.Key Takeaways✅ Clinicians are often far more entrepreneurial than they realize✅ Clinical excellence and business expertise are two different skill sets✅ Most clinician businesses struggle because nobody taught them foundational business systems✅ Entrepreneurship can be taught using frameworks clinicians already understand✅ Ethical sales looks a lot like informed consent✅ Community and environment play a huge role in entrepreneurial success✅ Building a business creates options, flexibility, and autonomyclinician entrepreneur, physician assistant, PA entrepreneur, healthcare entrepreneurship, clinician business owner, side hustle, passive income, clinician coach, clinician consultant, healthcare leadership, physician assistant podcast, entrepreneurship podcast, clinician CEO, small business owner, healthcare innovation, clinician creator, informed consent sales, ethical sales, marketing for clinicians, business systems, clinician coaching, clinician education, clinician entrepreneur collective, practice medicine electively, revenue diversification
In this episode of the Gladden Longevity Podcast, Dr. Gladden and Leslie Kenny delve into the intricacies of aging, health, and the role of spermidine in promoting longevity. They discuss the hallmarks of aging, Leslie's personal journey with autoimmune conditions, and the importance of empowerment and curiosity in health management. The conversation emphasizes the interconnectedness of health factors and the need for a holistic approach to wellness. In this conversation, Leslie Kenny and Dr. Gladden explore the potential of spermidine as a breakthrough in aging research, discussing its effects on health, longevity, and cellular processes like autophagy. They share personal experiences with spermidine, the challenges of clinical research, and the importance of redefining aging. The conversation also highlights resources for healthy aging and the significance of mindset in health management. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways · Spermidine positively impacts multiple hallmarks of aging. · Crosstalk between hallmarks of aging can enhance health. · Mindset plays a crucial role in health outcomes. · Patients should collaborate with their healthcare providers. · Curiosity in medicine leads to better patient outcomes. · The healthcare system often lacks time for curiosity. · Empowerment in health management is essential. · Modulating the immune system can restore balance. · Personal experiences can lead to significant health insights. · Holistic approaches to health can yield better results. Spermidine activates autophagy, aiding in cellular renewal. · Chronic management of illnesses is not desirable; patients want solutions. · Biological age can be significantly lower than chronological age. · Spermidine has potential benefits for heart health and cognition. · Personal experiences with spermidine show promising results in sleep quality. · Clinical trials for food-derived compounds face financial challenges. · The body can adapt and respond positively to the right inputs. · Redefining aging is crucial for a healthier future. · Mindset plays a vital role in health and aging. · Resources like Oxford Health Span can provide valuable information. Chapters 00:00 Introduction to Longevity and Health 05:23 The Role of Spermidine in Aging 08:52 Personal Journey with Autoimmune Conditions 12:34 Empowerment in Health Management 18:07 The Importance of Curiosity in Medicine 25:21 Finding Balance in Immune Health 31:32 The Quest for Longevity and Health 34:58 Spermidine: A Breakthrough in Aging Research 39:14 Personal Experience with Spermidine 44:40 Challenges in Clinical Research 49:52 Redefining Aging and Health 52:52 Resources for Healthy Aging To learn more about Leslie Kenny: Instagram: https://www.instagram.com/lesliesnewprime/ Website: oxfordhealthspan.com, lesliesnewprime.com Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
Vertical jump improved by over three centimetres in elite soccer players after just six weeks, simply by targeting one overlooked part of cellular biology: the mitochondria. Angela Foster talks with Dr Anurag Singh, Chief Medical Officer at Timeline, about the science of mitophagy, the process that clears out dysfunctional mitochondria, and how the clinically studied compound urolithin A supports it. They walk through real clinical trial data spanning soccer players, elite weightlifters and Olympic-level runners, with a particular focus on findings in women, exploring measurable gains in strength, power and recovery markers like reduced muscle damage and perceived effort. Listeners will learn why mitochondrial renewal takes weeks rather than days to show up, what it actually means when energy dips after stopping supplementation and rebounds on restarting, and why this matters especially for women navigating perimenopause, when recovery and inflammation can shift noticeably. Tune in to understand what's really happening at the cellular level behind your energy and recovery. KEY TAKEAWAYS Understand mitochondrial health as a three-stage cycle: biogenesis (creating new mitochondria), fission and fusion (making existing ones more efficient), and mitophagy (clearing out dysfunctional ones). Neglecting that final clearance step is, as Dr Singh puts it, like never taking the garbage out of a cluttered house. Expect mitochondrial and performance benefits to build gradually rather than instantly. Clinical studies show improved mitochondrial health in muscle tissue after one month, with measurable strength and power gains showing up after two to four months, so don't judge a mitochondria-targeted intervention by how you feel after a week. Pay attention to recovery markers, not just strength numbers, when evaluating training interventions. In a four-week study with elite runners, those taking mitopure showed lower rate of perceived exertion and lower creatine kinase, a muscle damage marker, suggesting easier recovery rather than just raw performance gains. Try a deliberate break from a supplement or intervention to gauge whether it's actually working for you. Both Angela and Dr Singh independently noticed an energy dip after stopping urolithin A supplementation, which is a practical way to separate real effect from placebo. Look for research that specifically includes women, since women are historically underrepresented in supplement and performance studies. Timeline's trials run roughly two-thirds female participants, which matters for understanding how recovery and inflammation patterns shift during phases like perimenopause. STANDOUT QUOTES "If we have a super cluttered house, there's only so much we can do to improve it. At one point, we've got to take out the garbage." — Dr Anurag Singh "Rome wasn't built in a day." — Dr Anurag Singh "It's the only thing we know outside of exercise and fasting that hits that mitochondria specific autophagy." — Dr Anurag Singh "I feel like I can do everything and have fun with my kids." — Angela Foster "That's the reason we're doing all this, right? It's our life. We want to live it healthily, fully." — Dr Anurag Singh VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body and how to fix it.
Geriatrician Dr. Mark Supiano joins the podcast to discuss the connection between heart and brain health. Citing multiple clinical trials, he breaks down what these studies and their findings mean for blood pressure management's effect on cognitive decline and how they directly impact both patients and clinicians. Guest: Mark A. Supiano, MD, geriatrician, University Hospital Geriatrics Clinic, professor, Internal Medicine, Utah School of Medicine Show Notes Read about the Systolic Blood Pressure Intervention Trial (SPRINT) Study on the National Heart, Lung, and Blood Institute website. Learn about the SPRINT MIND study in the Journal of the American Medical Association. Read Dr. Supiano's study, “Hypertension in the Oldest Old,” published by the Journal of the American College of Cardiology: Advances on their website. Learn about the HYVET, STEP, SPRINT-HEART and China Rural Hypertension Control Project studies through their articles on the National Library of Medicine website. Learn about an ancillary study to SPRINT, “Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment,” on the National Library of Medicine website. Learn about the Systolic Hypertension in the Elderly Program (SHEP) study, published by Clinical and Experimental Hypertension, on the Taylor and Francis Online website. Learn about the ESPRIT study on The Lancet website. Learn more about Dr. Supiano on the University of Utah Health website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production. Learn about Dr. Chin's book, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia.
THE HOMEOPATHY HEALTH SHOW The Language of Human Milk: Lac Remedies, Oxytocin & the Foundations of Human Development with Patricia Hatherly. Episode Summary - Part-1 In this episode of the Homeopathy Health Show, we are joined by internationally respected homeopath, lactation consultant, educator, and author Patricia Hatherley, whose pioneering work with the LAC remedies has transformed the understanding of milk-based remedies within modern homeopathy. Drawing on decades of clinical experience and research, Patricia explores the profound relationship between breastfeeding, attachment, oxytocin, early childhood development, and the healing potential of remedies such as Lac Humanum, Lac Maternum, Lac Caninum, and Lac Lupinum. Together, we examine how the earliest experiences of nourishment, bonding, birth, and maternal connection shape human development and how disruptions to these processes may manifest physically, emotionally, and psychologically throughout life. This fascinating conversation bridges homeopathy, developmental science, attachment theory, and the wisdom of nature, offering unique insights into some of the deepest themes encountered in clinical practice. In This Episode We Explore Patricia's Journey into Homeopathy and Breastfeeding How a lifelong passion for mothering and breastfeeding led Patricia into homeopathy. Her transition from teacher to lactation consultant and internationally recognised homeopathic educator. The personal experiences that shaped her groundbreaking work with milk remedies. The Evolution of the LAC Remedies The origins and development of Patricia's work with milk remedies. Understanding the significance of human milk within homeopathy. Why the LAC remedies represent some of the deepest developmental themes in healing. Lac Maternum and Lac Humanum The essential differences between these two important remedies. Lac Maternum and the impact of birth trauma. Lac Humanum and the consequences of disrupted breastfeeding and nurturing. Clinical indications and key differentiating themes. Oxytocin, Attachment and Human Development The role of oxytocin in bonding, regulation, and emotional development. How modern birth interventions may affect natural oxytocin pathways. The connection between attachment theory and homeopathic prescribing. Why early nurturing experiences remain central to lifelong wellbeing. Breastfeeding and the Developing Child The unique biological intelligence contained within human milk. The influence of breastfeeding on the microbiome and immune system. Cultural and societal challenges surrounding breastfeeding today. The long-term consequences of maternal-child separation. Clinical Insights and Case Studies Patricia's experience using Lac remedies in developmental and behavioural cases. A detailed discussion of autism-spectrum presentations and long-term treatment approaches. Potency considerations and practical prescribing insights. Lessons learned from decades of clinical observation. Lac Caninum, Adoption and Identity The deeper themes of abandonment, belonging, and loss of mother. Clinical applications of Lac Caninum. The remedy's polarity, sensitivity, and transformational potential. Connections between trauma, self-worth, and identity formation. Lac Lupinum and Protective Bonding The symbolism of the wolf and its relevance to remedy understanding. Themes of protection, loyalty, belonging, and family structure. Key proving symptoms and clinical observations. Understanding the developmental significance of healthy bonding. Homeopathy, Birth and Early Trauma How birth experiences influence lifelong health patterns. The role of homeopathy in supporting children following difficult births. Patricia's reflections on miasms, labour, and the law of cure. Why birth history remains an essential part of case-taking. Human Connection in a Technological Age The importance of preserving natural processes of conception, birth, and nurturing. Concerns surrounding increasing technological intervention in reproduction. The role of human connection in healthy development. Why maternal care remains one of society's most valuable resources. About Our Guest Patricia Hatherley Patricia Hatherley is an internationally respected homeopath, lactation consultant, educator, author, and researcher whose pioneering work with milk remedies has significantly influenced contemporary homeopathic understanding. Drawing upon decades of experience supporting mothers, infants, and families, Patricia has developed a unique integration of breastfeeding science, attachment theory, developmental psychology, and classical homeopathy. Her extensive work with Lac Humanum, Lac Maternum, and other milk remedies has provided practitioners worldwide with valuable insights into the profound impact of early nurturing experiences on health and development. Patricia is a sought-after international speaker and teacher, known for her practical clinical wisdom, compassionate approach, and ability to bridge modern developmental science with homeopathic philosophy. About the Homeopathy Health Show The Homeopathy Health Show - co-hosted and produced by Atiq Ahmad Bhatti and Naila Cheema - is the world's #1 homeopathy talk show, reaching a global audience through the UK Health Radio Network and all major podcast platforms. Atiq Ahmad Bhatti, a 4th Generation Homeopath, Teacher, Educator, and Global Ambassador for Homeopathy, is joined by Naila Cheema, an experienced Homeopath and Nutritionist. Together, they bring thoughtful conversations, expert insights, and a shared passion for holistic healing to every episode. Connect with the Hosts Atiq Ahmad Bhatti - Homeopath, Educator, Broadcaster Online: www.liketreatslike.co.uk Instagram: @like_treatslike Facebook: @liketreatslike YouTube: like_treatslike Naila Cheema - Homeopath, Nutritionist, Educator Online: https://homeopathynaila.com Instagram: @homeopathnaila Facebook: @Neeli.KC Stream Now Across All Platforms UK Health Radio: https://ukhealthradio.com/program/homeopathy-health/ Podbean: https://homeopathyhealth.podbean.com/ Apple Podcasts: https://podcasts.apple.com/us/podcast/homeopathy-health-with-atiq-naila/id1715524908 YouTube: https://www.youtube.com/@like_treatslike/featured Spotify: https://open.spotify.com/show/17rSCmlPGDkiSCyHePLPFx?si=51c640498df84727 Join Our Global Community of Listeners Hosted by: Atiq & Naila Top 5% Podcast Worldwide (ListenNotes Global Ranking) #1 Global Talk Show on Homeopathy Audience in 60+ Countries Real conversations. Real stories. Real homeopathy. Unlock the power of natural remedies to restore balance and vitality. Inspiring guests, expert insights, and global voices shaping the future of holistic medicine. Tune in, stay inspired, and explore the world of homeopathy with us. Homeopathy in Practice Explore webinars, masterclasses, education, and practitioner resources at: https://homeopathyinpractice.co.uk Join our global Facebook community @homeopathyinpractice
You've been using your veterinary AI note taker for a couple of years now - it's great - saves you heaps of time. But are you using it to its full potential?I'll take a bet that you're not. These things move fast, and it's hard to keep up. Which is why, in our Tech for Vets Series, we pull apart the veterinary tools that are changing how we work, and this time we put Heidi up on our screens for a detailed walk through. Our guide is Dr Kieran McLeod, head of medical knowledge at Heidi Health. We start by putting the scribe through its paces to find the workflow tricks that you're probably missing - I walked away with at least five tricks I'd never used. Then Kieran shows off all the shiny new AI magic coming your way: voice agents, built-in clinical support and a hardware solution that lets you leave your phone in your bag. You'll learn:The scribe features you're almost certainly ignoring - linked patients, the context window, smart dictation, and the one-click voice edits that mean you never type a note correction againThe AI voice agent that makes the phone call you've been dreading What baked-in clinical decision support looks likeHow to safety-net the worry that keeps you up - that quiet "did I miss something?" feelingHow to incorporate hands-free hardware into your workflowThis is a screen-share walkthrough, so head to Spotify if you want to watch the clicks rather than just hear us talk about them.Show notes and details live at thevetvault.comGet clinical support from human specialists at the Vet Vault Specialist Support SpaceGet rid of your mid-year 'meh' at our Vets On Tour New Zealand snow conferenceTopics and Timestamps02:35 Intro: Beyond the scribe005:18 Human-first vs. vet-first: does it matter?09:17 Note-taking basics09:46 Context windows & linked patients15:46 Multiple documents & the source of truth18:49 Smart Dictation for quick edits29:38 Sync changes across documents33:10 Task lists36:06 Collaboration & session sharing40:07 Sharing & exporting documents41:22 Heidi Comms: AI voice agents53:46 Heidi Evidence: clinical decision support01:04:50 Using Evidence for complex histories01:09:11 Evidence sources & collections01:14:01 Heidi Remote: the hardware mic01:21:46 EMR integrations (ezyVet & Covetrus)
The First Thing I Teach A New Associate (And It's Not Clinical) | E310Highlights from this episode: The First Thing I Teach A New Associate (And It's Not Clinical) (00:58)Closing Thought: What Only Time Can Teach (15:21)When I'm training a new associate, I'm not starting with dry eye, myopia, or advanced disease management—I'm starting with communication, connection, and the fundamentals that create an extraordinary patient experience. In this episode, we're talking about why the little things like preparation, eye contact, patient handoffs, and authentic conversations matter more than most doctors realize, and how those small improvements compound into massive business growth over time. We talk about the danger of chasing shortcuts, the power of consistency, and why being just a little bit better every day beats trying to be perfect. If you're building a practice, developing associates, or leading a team, this episode is a reminder that greatness is usually found in the fundamentals.Join in the conversation and subscribe to the podcast to keep up with all the great content coming down the pipe! For exclusive content, be sure to register your email on our website and I will be sending out newsletters and other great bonuses as we go. I love getting feedback, questions, suggestions, etc. so contact me atwww.theultimateod.com, on social media (click here for ->YouTube,Twitter,Instagram,Facebook) OR, just shoot me an email at drlillie@theultimateod.com and I'd be happy to chat!
Serious mistakes led to an 11-year-old Maori autistic girl being misidentified as an adult mental health patient, before she was restrained and twice injected with anti-psychotic medications. Dr Richard Sullivan, who's Health New Zealand's Executive National Director, Clinical spoke to John Campbell.
Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shelby Williams.
What if healthcare understood neurodivergence differently?Welcome to Clinical Misfits, a podcast exploring neurodivergent health, medicine, and clinical understanding through an autistic cultural lens. Part of the Autistic Culture Podcast Network.Hosted by Dr Mary Sims, a neurodivergent neurologist who is AuDHD herself, the series combines lived experience and medical expertise to explore the physical, neurological, and systemic realities of neurodivergence.From burnout and the autonomic nervous system to hormones, genetics, and immune system interactions, Clinical Misfits challenges assumptions and offers new ways of understanding neurodivergent health.
The medical establishment spent decades telling patients that type 2 diabetes is a chronic and irreversible disease. Today's guest decided to prove them wrong.Sami Inkinen is the co-founder and CEO of Virta Health, a company using a combination of nutrition science, remote monitoring technology, and individualized coaching to help patients reverse type 2 diabetes, obesity and other metabolic conditions. Previously, Sami co-founded Trulia, the online real estate marketplace, serving as COO and president through its IPO and eventual sale to Zillow. He has also held roles at Microsoft and McKinsey, and rowed from California to Hawaii with his wife to raise awareness of the dangers of sugar.Sami joins us to talk about how his own health journey influenced his decision to start Virta, the challenges of scaling in the health space, and the incredible success they've had in treating metabolic disease. Highlights:A personal pre-diabetes diagnosis (2:35)Lessons from Trulia (6:00)Why reversal, not management (9:30)Clinical results and outcomes (12:47)GLP-1s and Virta's approach (15:26)Technology and personalization (17:33)Selling to employers (20:17) Overcoming the status quo (22:33)Building a full-stack team (25:15)Rowing California to Hawaii (28:30)Goals for ‘26 into ‘27 (30:58)Links:Sami Inkinen LinkedInVirta Health LinkedInVirta Health WebsiteICR LinkedInICR TwitterICR Website Feedback:If you have questions about the show, or have a topic in mind you'd like discussed in future episodes, email our producer, joe@lowerstreet.co
Zach, Kevin and Al have been tiptoeing around it for three episodes, but today we do a deep dive on the Rock and Roll Hall of Fame! The guys break down the highly secretive, two-step nomination process—debunking the illusion of the "fan vote"—and call out the historical genre biases that left iconic stadium rock, heavy metal, and progressive bands frozen out for decades. From debating the definition of "innovation" versus "commercial success" to throwing down over legendary snubs like The J. Geils Band, Weird Al, and INXS, this episode is a passionate, witty look at the politics, snobbery, and enduring legacy of the music that shapes our culture. Some links from the show: The Rock and Roll Hall of Fame How induction works The fake "fan vote" Join the Very Clinical Facebook group! Join the Very Dental Facebook Group using one of these passwords: Timmerman, Paul, Bioclear, Hornbrook, Gary, McWethy, Papa Randy, or Lipscomb! The Very Dental Podcast network is and will remain free to download. If you'd like to support the shows you love at Very Dental then show a little love to the people that support us! We're proud to be supported by the folks at Net32! I'm a big fan of the Bioclear Method! I think you should give it a try and I've got a great offer to help you get on board! Use the exclusive Very Dental Podcast code VERYDENTAL8TON for 15% OFF your total Bioclear purchase, including Core Anterior and Posterior Four day courses, Black Triangle Certification, and all Bioclear products. Crazy Dental has everything you need from cotton rolls to equipment and everything in between and the best prices you'll find anywhere! If you head over to verydentalpodcast.com/crazy and use coupon code "VERYSHIP" you'll get free shipping on your order! Go save yourself some money and support the show all at the same time! The Wonderist Agency is basically a one stop shop for marketing your practice and your brand. From logo redesign to a full service marketing plan, the folks at Wonderist have you covered! Go check them out at verydentalpodcast.com/wonderist! Enova Illumination makes the very best in loupes and headlights, including their new ergonomic angled prism loupes! They also distribute loupe mounted cameras and even the amazing line of Zumax microscopes! If you want to help out the podcast while upping your magnification and headlight game, you need to head over to verydentalpodcast.com/enova to see their whole line of products! CAD-Ray offers the best service on a wide variety of digital scanners, printers, mills and even their very own browser based design software, Clinux! CAD-Ray has been a huge supporter of the Very Dental Podcast Network and I can tell you that you'll get no better service on everything digital dentistry than the folks from CAD-Ray. Go check them out at verydentalpodcast.com/CADRay!
Send us Fan MailWhat does it mean to truly improve outcomes for very low birth weight infants, and are we actually doing it? In this episode, Daphna sits down with Dr. Joseph Kaempf, neonatologist and Medical Director of Value Research and Innovation at Providence Health System in Oregon, to examine some uncomfortable truths about neonatal quality improvement. Dr. Kaempf shares findings from a study spanning 16 NICUs over 14 years showing that composite morbidity outcomes have remained flat while length of stay has increased. He explores why traditional QI tools like driver diagrams and PDSA cycles may no longer be sufficient, and why augmented intelligence may be the next frontier. The conversation also touches on culture as a driver of NICU performance and the gap between institutional interests and true shared decision-making with families. A candid episode for anyone invested in the future of neonatology.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Today we have another Pulm PEEPs Pearls episode about a core critical care topic. Furf and Monty will be giving a high level overview of the use of steroids in sepsis including a review of the relevant literature and recent guidelines, and pragmatic bedside points. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points Why Steroids in Sepsis? Steroids do not treat the infection — antimicrobials are always first and remain the cornerstone. The goal is addressing critical illness–related corticosteroid insufficiency (CIRCI), where cortisol production cannot keep up with the overwhelming inflammatory demand of septic shock. Hydrocortisone helps in two main ways: Blunts the dysregulated inflammatory response — tempers the excessive vasodilation and febrile response that drive harm beyond the infection itself. Restores vascular sensitivity to catecholamines — sepsis downregulates adrenergic receptors; steroids turn that responsiveness back on. Clinical takeaway: The first thing you notice is vasopressor weaning (or a bend in the escalation curve) — not a rapid improvement in fever or white count. Caveat: These trials predate modern sepsis phenotyping. None distinguish hyperinflammatory vs. hypoinflammatory responders — they treat all comers. The Evidence: Four Landmark Trials Every IM resident and critical care fellow will eventually journal-club these four. The most consistent signal across all of them is faster shock reversal and reduced vasopressor use; the mortality question remains unsettled. Trial (Year)NRegimenKey FindingAnnane (2002)~300Hydrocortisone + fludrocortisoneMortality benefit in ACTH non-responders; criticized methodology and messy cortisol-response testing; not cleanly replicated.CORTICUS (2008)~500Hydrocortisone aloneFaster shock reversal but no mortality benefit, regardless of cortisol responsiveness. Raised (later allayed) superinfection concern. Cornerstone for abandoning routine cort-stim testing.ADRENAL (2018)~3,800Hydrocortisone aloneFaster vasopressor weaning; no 90-day mortality benefit.APROCCHSS (2018)~1,200Hydrocortisone + fludrocortisoneMortality benefit at 90 days. Bottom line: Faster shock reversal is consistent. Mortality benefit appears in 2 of 4 trials (both used fludrocortisone) but not the others. A 2026 meta-analysis showed benefit for hydrocortisone + fludrocortisone vs. placebo, but not for hydrocortisone + fludrocortisone vs. hydrocortisone alone — suggesting hydrocortisone drives the main effect. Who Gets Steroids, and When? 2021 Surviving Sepsis: Consider steroids for norepinephrine or epinephrine ≥ 0.25 mcg/kg/min for ≥ 4 hours despite adequate resuscitation — a reasonable bedside trigger. Early 2026 update: Moved away from a specific numeric trigger — consider steroids when a septic patient is not responding well to vasopressors or has escalating requirements. Make a clinical decision. (Quality of evidence: low to moderate.) Go faster than the threshold when: Known/suspected adrenal insufficiency or home steroids, or florid pressor-requiring shock on arrival. A practical escalation sequence: escalating norepinephrine → add vasopressin (per VASST) → then add steroids if requirements keep climbing. Do NOT wait for an ACTH stimulation test. It does not reliably predict who responds and only delays treatment. Sepsis is an elevated-cortisol state but can dissociate ACTH and cortisol, and cortisol-binding globulin is depleted — the test is too messy to guide care. What to Give: The Regimen Standard dose: Hydrocortisone 200 mg/day, typically 50 mg IV Q6H. (Original trials often used continuous infusions, rarely used in the U.S.) Some start with a 100 mg bolus to gain control. Higher dose: If chronically on steroids / adrenally insufficient, consider ~300 mg/day (e.g., 100 mg Q8H). Fludrocortisone: Unsettled. The two mortality-benefit trials added it (50 mcg PO/NG/OG daily), but hydrocortisone already has mineralocorticoid activity and meta-analyses don't show added benefit over hydrocortisone alone. Most clinicians omit it — adding it is reasonable and safe, just be honest about the uncertainty. Duration & Tapering Typical course: ~7 days is most common. Trial practices varied (ADRENAL ~7 days; VANISH used a taper after 6 days; some continue until pressors are off). No taper needed. You do not need to taper for adrenal insufficiency after a short course — just stop. If pressors dramatically rebound, you can restart, but most patients have gained the benefit they'll get by day 7. Pitfalls & Safety Hyperglycemia: Expected and must be managed (monitor closely; insulin drip if needed). No signal for major DKA / severe complications in the trials. Superinfection / fungal infection: The most-quoted concern, but the overall literature does not show a convincing, statistically significant increase. Be disciplined about stopping on schedule. Muscle weakness: Steroids can worsen critical illness myopathy; a short 7-day course likely has limited effect, but be aware. Other: GI bleeding (follow general PPI prophylaxis guidance) and sodium disturbances (watch for hyper-/hyponatremia). Two things we know: (1) steroids shorten duration of vasopressor support, and (2) they are relatively safe in sepsis. Whether they improve mortality — and in whom — remains open. The Five Pulm PEEPs Pearls Mechanism: Steroids restore catecholamine vascular sensitivity and blunt dysregulated inflammation. The clinical target is vasopressor weaning, not infection treatment. Evidence: Faster shock reversal is the most consistent finding. Mortality benefit is seen in 2 of 4 trials but not the others — still controversial. Some patients likely benefit; we don't yet know who. Trigger: A practical 2021 threshold is levo/epi ≥ 0.25 mcg/kg/min for ≥ 4 hours. Newer guidance drops the strict number — make a clinical decision based on poor pressor response or escalation. Dose: Hydrocortisone 200 mg/day (e.g., 50 mg Q6H). Adding fludrocortisone mirrors two trials, but meta-analyses find no benefit over hydrocortisone alone. Safety: Steroids appear safe in sepsis. Monitor and treat hyperglycemia; no marked increase in superinfection. References and Further Reading Annane, Djillali et al. “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.” JAMA vol. 288,7 (2002): 862-71. doi:10.1001/jama.288.7.862 Sprung, Charles L et al. “Hydrocortisone therapy for patients with septic shock.” The New England journal of medicine vol. 358,2 (2008): 111-24. doi:10.1056/NEJMoa071366 Venkatesh, Balasubramanian et al. “Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 797-808. doi:10.1056/NEJMoa1705835 Annane, Djillali et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 809-818. doi:10.1056/NEJMoa1705716 Sun, Alin et al. “Correction: Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.” Frontiers in medicine vol. 13 1811616. 2 Mar. 2026, doi:10.3389/fmed.2026.1811616 Prescott, Hallie C et al. “Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.” Critical care medicine vol. 54,4 (2026): 715-724. doi:10.1097/CCM.0000000000007089
What happens to the brain when men become fathers? Clinical psychologist and neuroscientist Darby Saxbe studies how investing in caregiving changes the brains and bodies of men.. Darby and Adam examine the surprising similarities between dad and mom brains and the different mechanisms that activate them. They also discuss the effects of having a daughter on men's empathy and generosity, the hormonal mechanism behind “dad bods,” and the case for workplaces to grant parental leave to men as well as women.Featured guestFollow Darby Saxbe on Instagram and https://www.darbysaxbe.com/Subscribe to her Substack, Natal GazingBuy Dad Brain: The New Science of Fatherhood and How it Shapes Men's LivesConnect with the teamFollow Adam on Instagram, LinkedIn, and at adamgrant.net/Subscribe to Adam's substack GrantedWatch ReThinking videos on YouTube at TEDAudioCollectiveFollow TED on X, Instagram, Facebook, LinkedIn, and TikTokReThinking is produced by Cosmic Standard. Our Senior Producer is Jessica Glazer, our Engineer is Aja Simpson, our Technical Director is Jacob Winik, and our Executive Producer is Eliza Smith.For the full text transcript, visit ted.com/podcasts/rethinking-with-adam-grant-transcripts Hosted on Acast. See acast.com/privacy for more information.
What if healing wasn't random? What if the body was designed with intelligence, order, rhythm, and frequency built into it? In this powerful philosophical episode of the MoChihChu Podcast, Dr. Fred Schofield unpacks "The 7 Levers" a deep dive into chiropractic philosophy, nervous system communication, spinal alignment, frequency, tone, healing, self-regulation, and the true purpose of the adjustment. This isn't surface-level chiropractic talk. This episode bridges ancient principles, modern nervous system science, innate intelligence, spinal biomechanics, breathwork, energy, heart rate variability, posture, clinical certainty, and the foundational laws that govern healing and human performance. Dr. Fred explores: The neurological connection between the brainstem and body Chiropractic adjustments and frequency restoration The meaning of subluxation and nervous system interference Why structure influences function How stress, cortisol, and poor tone affect healing The role of posture, breathing, movement, and spinal molding Heart rate, vitality, and nervous system adaptability Clinical certainty and patient communication Self-healing, autopoiesis, and innate intelligence Why consistency and discipline create long-term transformation From Palmer philosophy and upper cervical concepts to practical patient care and personal development, this episode is packed with searchable, thought-provoking conversations around chiropractic healing, wellness, nervous system regulation, holistic health, and peak performance. If you're a chiropractor, chiropractic student, wellness practitioner, or someone passionate about health, healing, energy, mindset, and the power of the human body… this episode will challenge the way you think about healing itself. "You are self-organizing. You are self-regulating. You are self-restoring." - Dr. Fred Schofield Subscribe, share, and step deeper into the philosophy, science, and art of chiropractic.
Enjoy the ride as we go through a case of syncope with the Clinical Problem Solvers! Listen in awe as they break down their thought process when evaluating a patient presenting with syncope. We are joined by Reza Manesh (UCLA) and Rabih Geha (UCSF).Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMEShow Segments Intro Aliquot 1 and case discussion Aliquot 2 and case discussion Aliquot 3 and case discussion Aliquot 4 and case discussion Aliquot 5 and case discussion Final Diagnosis Outro Credits Producers: Matthew Watto MD, FACP; Edison Jyang, MD Clinical case writers: Youssef Saklawi, MD; Madallena Conte, MD Show notes, infographic, and cover art: Edison Jyang, MD Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP Reviewer: Emi Okamoto, MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Reza Manesh, MD; Rabih Geha, MD DisclosuresDr. Reza Manesh reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures. Sponsor: FIGSCurbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX.Sponsor: QuinceGo to Quince.com/curb for free shipping on your order and 365-day returns. Now available in Canada, too.
Your body isn't broken - your subconscious is running old programs. Clinical hypnotherapist Lydia Hatton joins Dr. Tabatha to unpack how childhood beliefs drive stress eating, weight struggles, and self-sabotage - and how to finally rewrite them. Romans 12:2 in action. What if the reason you can't stop stress eating, sabotaging your health goals, or staying stuck in the same patterns has nothing to do with willpower - and everything to do with a belief installed in your subconscious before age seven?In this episode, Dr. Tabatha sits down with Lydia Hatton - Clinical Hypnotherapist, Mindset Coach, Columbia and Harvard MBA grad - to pull back the curtain on the hidden programs running your body, your eating habits, and your self-worth.Lydia discovered hypnotherapy after a thyroid cancer diagnosis during COVID, and what she found on the other side changed everything - including her work with women inside the Fast to Faith community.You'll learn:Why 95% of your thoughts are subconscious - and how they're quietly shaping your lifeHow limiting beliefs installed in childhood drive emotional eating, weight holding, and self-sabotageWhy "weight loss" language may actually be keeping you stuckHow to reprogram your mind with new truth - and why repetition is non-negotiableWhat hypnotherapy actually is (and why it is not scary, demonic, or out of your control)"Your entire body field is listening to the words you speak at all times." - Lydia Hatton"You have to believe before you receive." - Ashlee"You can't have this dissonance of your mind and your spirit. You have to be going in the same direction to move your body forward." - Dr. TabathaScripture: Philippians 2:1-2Connect with Lydia:Website: lydiahatton.com (book a discovery call)Email: lydia@lydiahatton.comYouTube: Lydia Hatton MBAIf you've been on your own healing journey and you keep thinking, I want to help other women do this! That pull is not random. The Fast to Faith Coaching Academy was built for you. You'll learn the clinical foundations hormones, gut healing, labs, supplementation & how to coach women through the 40-Day process while building a business that honors both science & faith. Join Today! For just five dollars, you get five days with a certified one-on-one coach guiding you through your hormones, your gut, and your faith.Go to ftf.fasttofaith.com/empoweredbyfaithdiyReady to go deeper?The women who hear this episode and feel something shift — they belong in the Fast to Faith Sisterhood. This is where faith, functional medicine, and identity work come together with a community of women who are done managing symptoms and ready to lead from healing.If you feel called to take that even further — to guide other women through this exact transformation — the Fast to Faith Coaching Academy is where that calling becomes a career.Become a certified Fast to Faith™ coach →Weekly live mentorship with Dr. TabathaNot ready for the academy yet? Start here: 5-Day Empowered by Faith Challenge ftf.fasttofaith.com/empoweredbyfaithdiyShop Dr. Tabatha's supplement line: Use code PODCAST for 20% off your first order: shop.fasttofaith.comGet the book: Fast to Faith: A 40-Day Awakening: book.fasttofaith.com/bonus?am_id=fasttofaith5413Fast to Faith is hosted by Dr. Tabatha Barber — OB/GYN, functional medicine physician, and founder of the Fast to Faith Sisterhood and Coaching Academy.
The quality of our attention shapes every interaction we have, yet listening is often the first skill sacrificed when pressure, technology, and time constraints take over. Most clinicians spend years learning what to say, while spending little time learning how to effectively listen. In a healthcare system dominated by tasks, metrics, and efficiency, the ability to slow down and create genuine presence may be one of the most valuable skills we can cultivate.In this episode, we explore why listening is both a mindset and a practical skill, how to listen more effectively, how small pauses can transform patient care, and why mindfulness extends far beyond meditation. Finally, we examine simple practices that help clinicians stay present, focused, and connected even during the busiest days.
PODCAST EPISODE | Redefining CyberSecurity With Sean Martin — On Location at InfoSecurity Europe 2026 On Location With Sean Martin And Marco Ciappelli Adversaries are stealing encrypted data today that they cannot read yet, and storing it until a quantum computer can. Sean Martin sat down with Forescout's Rik Ferguson to talk about “harvest now, decrypt later,” why Q-Day is closer than the comfortable timelines suggest, and what the decisions you make this year have to do with secrets you thought were safe forever.
What if the experience you think makes you an outsider in the design industry is actually your greatest advantage? In this episode of Designed for the Creative Mind, Michelle Lynne sits down with interior designer Katie Rainey to discuss her journey from Doctor of Physical Therapy to owner of a thriving interior design firm specializing in waterfront and lifestyle-driven homes. Katies design philosophy is that beauty and function are necessities, not luxuries. With a Doctorate in Physical Therapy and a background in human movement, she crafts spaces that are both beautiful and intuitively designed for real life. She partners with busy families and professionals seeking solace in nature - whether by the water in Annapolis or in the mountains of New Hampshire - guiding them through the intricacies of a renovation or a new build. With deep construction knowledge, she collaborates closely with builders and architects to ensure seamless execution from concept to completion. As part of a military family, Katie has lived across the U.S. and in Europe. She draws inspiration for her designs from this global design perspective, having lived in diverse landscapes. Katie shares how she initially hid her medical background, believing it had little relevance to design, only to discover that her expertise in movement, ergonomics, and human behavior became one of her strongest differentiators. From designing custom solutions that improve clients' daily lives to building a business rooted in confidence, process, and professionalism, Katie offers valuable lessons for designers at every stage of business. The conversation also explores networking, pricing, client communication, boundaries, and the mindset shifts that helped Katie transition from treating design as a passion to running it as a profitable business. Whether you're transitioning from another career, struggling to communicate your value, or looking for encouragement to own your unique story, this episode is packed with practical wisdom and inspiration. In This Episode, We Discuss: Katie's transition from physical therapy to interior design Why your previous career can become your biggest business advantage Using ergonomics and human movement to create more functional homes How Katie found her unique positioning in the design industry The mindset shift from hobbyist to business owner Learning to separate emotion from sales conversations The "Pass the Salt" approach to discussing money with clients Why clear processes create better client experiences Educating clients through deliverables and expectations The importance of boundaries and scope management Networking strategies that helped Katie build a business in a brand-new market How confidence and consistency lead to stronger business growth Balancing motherhood, business ownership, and personal fulfillment Key Takeaways Your Past Experience Is Part of Your Expertise Katie spent years downplaying her background as a physical therapist before realizing it gave her a unique perspective that directly benefits her clients. The skills, knowledge, and experiences from previous careers often become the very thing that sets designers apart. Design Is More Than Making Things Beautiful A successful design must function for the people who live in it. Katie's understanding of ergonomics and movement helps her create spaces that support her clients' lifestyles while remaining beautiful. Confidence Comes from Process One of Katie's biggest business breakthroughs came from developing a clear process and communicating it effectively. When clients understand what to expect, they feel more confident moving forward. Networking Doesn't Have to Be Complicated From introducing herself to architects to striking up conversations at the gym and ice rink, Katie demonstrates that meaningful business relationships often start with a simple conversation. Business Growth Requires Personal Growth Success isn't just about improving your design skills. It's about developing confidence, setting boundaries, understanding your value, and learning how to lead clients through decisions. Memorable Quotes "Own your background. Whatever you did before design, there's something there that makes you a better designer." "If it looks beautiful but doesn't function for you, what's the point?" "You're not trying to convince clients to hire you. You're guiding them as the expert." "We are a for-profit company, not a non-profit." "We're most memorable in person, not behind our computer." "Whoever is going to hire me isn't going to hire you because I'm not you and you're not me." Connect with Katie Rainey Website: katieraineydesign.com Instagram: @katieraineydesign Facebook: Katie Rainey Design Connect with Michelle Lynne If you enjoyed this episode, be sure to subscribe, leave a review, and share it with a fellow interior designer who could benefit from today's conversation. For coaching, mentorship, and business resources for interior designers, visit our website at thedesignbakehouse.com. Loved This Episode? Leave a review and share this episode with another designer who needs the reminder that their unique background isn't something to hide—it's something to build on.
Join the Behind the Knife Surgical Oncology Team as we discuss clinical challenges through case-based examples including the diagnosis, workup, and management of patients with cutaneous melanoma. Learning Objectives:In this episode, we review the workup and management of patients with cutaneous melanoma and both microscopic and macroscopic nodal disease. References used in the making of this episode: Reijers, I.L.M., Menzies, A.M., van Akkooi, A.C.J. et al. Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial. Nat Med 28, 1178–1188 (2022). https://doi.org/10.1038/s41591-022-01851-x Christian U. Blank et al. Neoadjuvant nivolumab plus ipilimumab versus adjuvant nivolumab in macroscopic, resectable stage III melanoma: The phase 3 NADINA trial.. J Clin Oncol 42, LBA2-LBA2(2024). DOI:10.1200/JCO.2024.42.17_suppl.LBA2 Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med. 2017;376(23):2211-2222. doi:10.1056/NEJMoa1613210 https://pubmed.ncbi.nlm.nih.gov/28591523/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Cutaneous Melanoma. Version 1.2026. Accessed April 8, 2026. NCCN Guidelines PDF Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
Want to start clinicals with more confidence? Walking in, already knowing these 8 common labs inside and out will definitely give you an edge when it comes to interpreting your patients lab results and understanding important components of their care plan. Still nervous about starting clinicals? One of the best ways to fast-track your clinical learning is having the right tools. And you're in luck, I've put together a Clinical Success Pack which includes report sheets, sheets to help you plan your day, a clinical debrief form, and a patient safety cheat sheet. Download it now for free