Podcast appearances and mentions of Randy Q Cron

Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Randy Cron, MD, PhD, Professor of Pediatrics and Medicine at the University of Alabama at Birmingham (UAB) and the Arthritis Foundation, Alabama chapter endowed chair in Pediatric Rheumatology. Ira Pastor Comments: As we are a few months into the COVID-19 pandemic, a medical term we’ve been hearing mentioned quite a bit it in the press in terms of the pathophysiology of the infection, is that of Cytokine Release Syndrome (CRS) or Cytokine Storm Syndrome (CSS) is a form of systemic hyper-inflammatory response that can be triggered by a variety of factors such as infections, as well as certain drugs. CRS / CSS occurs when large numbers of white blood cells are activated and release inflammatory cytokines (which are a broad category of proteins important in cell signalling) which in turn activate yet more white blood cells, and the cycle repeats in a very dangerous and deadly cascade which can harm and kill patients via systemic hyper-inflammation, hypotensive shock, and multi-organ failure. Just a few months ago, the Springer publishing organization released a text entitled "Cytokine Storm Syndrome" - a first of its kind book to addresses all aspects of this unique disorder, from genetics, pathophysiology, and ongoing research related to clinical presentations, risk factors, and treatment. Dr. Randy Cron: Today we are joined by one of the co-authors of this book, Dr. Randy Q. Cron, MD, PhD, Professor of Pediatrics and Medicine at the University of Alabama at Birmingham (UAB) and the Arthritis Foundation, Alabama chapter endowed chair in Pediatric Rheumatology. Dr. Cron is also the Director of the Division of Pediatric Rheumatology and the Pediatric Rheumatology fellowship program at Children's of Alabama, a private not-for-profit, which provides specialized medical care for ill and injured children, and is ranked among the best pediatric medical centers in the U.S. Dr. Cron received his medical degree from UCLA and a doctorate in Immunology from the University of Chicago, with Pediatric residency training at Stanford Children’s Hospital in California and Pediatric Rheumatology fellowship training at Children’s Hospital and Medical Center in Seattle. Dr. Cron is board-certified in Pediatric Rheumatology, is the past president of the Alabama Society for Rheumatic Diseases, and a member of American Academy of Pediatrics, Society for Pediatric Research, American Association of Immunologists, American College of Rheumatology and numerous other professional organizations. His major research interests include: dysregulation of CD154 protein that is primarily expressed on activated T cells in systemic lupus erythematosus; CD4 T cell host factor regulation of HIV-1 LTR transcriptional activity and latency; genetic mutations leading to defective lymphocyte cytolytic activity; diagnosis and treatment of temporomandibular joint arthritis in childhood arthritides, and the diagnosis and treatment of Macrophage Activation Syndrome (MAS), a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood, and a component of the umbrella of conditions that make up CRS/CSS. On this episode we will hear from Dr. Cron about: His background: he developed an interest in pediatric medicine, immunology, and the very specialized pathology of CRS/CSS. An overview of CRS/CSS and conditions under the CRS/CSS umbrella including Macrophage Activation Syndrome and Hemophagocytic Lymphohistiocytosis. Treatment modalities for CRS/CSS. The connection between CSS and Acute Respiratory Distress Syndrome (ARDS); a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs, and responsible for many deaths in COVID-19 patients. His views on the use of the lupus drug Hydroxychloroquine in COVID-19 patients. Credits: Ira Pastor interview video, text, and audio. Follow Ira Pastor on Twitter: @IraSamuelPastor Follow ideaXme on Twitter: @ideaxm On Instagram: @ideaxme Find ideaXme across the internet including on iTunes, SoundCloud, Radio Public, TuneIn Radio, I Heart Radio, YouTube, Google Podcasts, Spotify and more. ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.

Audio abstract for the published article: Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations by Peter Stoustrup, Cory M. Resnick, Thomas Klit Pedersen, Shelly Abramowicz, Ambra Michelotti, Annelise Küseler, Carlalberta Verna, Christian J. Kellenberger, Ellen Berit Nordal, Giuliana Caserta, Iveta Jankovska, Josefine Mareile Halbig, Kasper Dahl Kristensen, Linda Z. Arvidsson, Lynn Spiegel, Mathew L. Stoll, Melissa Lerman, Mia Glerup, Patrizia Defabianis, Paula Frid, Per Alstergren, Randy Q. Cron, Sarah Ringold, Sven Erik Nørholt, Timo Peltomäki, Troels Herlin, Zachary S. Peacock, Marinka Twilt and the TMJ Juvenile Arthritis Working Group The Journal of Rheumatology May 2019, 46 (5) 518-522; DOI: https://doi.org/10.3899/jrheum.180785

The Journal of Rheumatology's Editor-in-Chief Earl Silverman talks about this month's selection of articles that are most relevant to the clinical rheumatologist. This month's selections include: Toward Defining Primary and Secondary Nonresponse in Rheumatoid Arthritis Patients Treated with Anti-TNF: Results from the BioTRAC and OBRI Registries by Edward C. Keystone, Emmanouil Rampakakis, Mohammad Movahedi, Angela Cesta, Melissa Stutz, John S. Sampalis, Francois Nantel, Karina Maslova and Claire Bombardier DOI: https://doi.org/10.3899/jrheum.190102 Insurance Payer Type and Patient Income Are Associated with Outcomes after Total Shoulder Arthroplasty by Jasvinder A. Singh and John D. Cleveland DOI: https://doi.org/10.3899/jrheum.190287 Retinal Complications in Patients with Systemic Lupus Erythematosus Treated with Antimalarial Drugs by Elvis-Raymond Mukwikwi, Christian A. Pineau, Evelyne Vinet, Ann E. Clarke, Emil Nashi, Fares Kalache, Louis-Pierre Grenier and Sasha Bernatsky DOI: https://doi.org/10.3899/jrheum.181102 Renal Parenchymal Thickness in Patients with Systemic Sclerosis Is Related to Intrarenal Hemodynamic Variables and Raynaud Renal Phenomenon by Antonietta Gigante, Biagio Barbano, Maria Ludovica Gasperini, Viviana Zingaretti, Rosario Cianci and Edoardo Rosato DOI: https://doi.org/10.3899/jrheum.190165 Changes in the Presentation of Incident Gout and the Risk of Subsequent Flares: A Population-based Study over 20 Years by Mohanad M. Elfishawi, Nour Zleik, Zoran Kvrgic, Clement J. Michet Jr., Cynthia S. Crowson, Eric L. Matteson and Tim Bongartz DOI: https://doi.org/10.3899/jrheum.190346 The Rheumatologist's Role in COVID-19 by Randy Q. Cron and W. Winn Chatham DOI: https://doi.org/10.3899/jrheum.200334 Possible Consequences of a Shortage of Hydroxychloroquine for Lupus Patients Amid the COVID-19 Pandemic by Christine A. Peschken https://doi.org/10.3899/jrheum.200395 Learning from Adversity: Lessons from the COVID-19 Crisis by Michael S. Putman and Eric M. Ruderman DOI: https://doi.org/10.3899/jrheum.200411 To read the full articles visit www.jrheum.org Music by David Hilowitz

Cohosts Gary Wörtz, MD, and Blake Williamson, MD, MPH, connect with rheumatologist Randy Q. Cron, MD, PhD, to discuss cytokine storm syndrome in patients with COVID-19. They are joined by Laura Periman, MD, and William B. Trattler, MD.

Cohosts Gary Wörtz, MD, and Blake Williamson, MD, MPH, connect with rheumatologist Randy Q. Cron, MD, PhD, to discuss cytokine storm syndrome in patients with COVID-19. They are joined by Laura Periman, MD, and William B. Trattler, MD.

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment

Systemic Juvenile Idiopathic Arthritis: A Closer Look at the Burden on Patients and Caregivers From Diagnosis to Treatment