Podcasts about Singh

This is episode 80, “A Catastrophic Ruling: The Overturning of Guaranteed Abortion Access.” My guest, Diljeet Singh, MD, is board certified in OB/GYN and Gynecologic Oncology. She also has an MPH in Maternal and Child Health, and a Ph.D. in Health Services Research. Dr. Singh currently practices in the Washington D.C. metro area.  Do not miss this episode as Dr. Singh discusses how ending women's guaranteed right to abortions will seriously harm women's health. I am including a link to this New York Times article, "Deleting Your Period Tracker Won't Protect You," because some people may find it useful.

In this episode of the Epigenetics Podcast, we caught up with John Rinn from the University of Colorado in Boulder to talk about his work on the role of lncRNAs in gene expression and nuclear organization. The Rinn Lab pioneered the approach of screening the human genome for long noncoding RNAs (lncRNAs). More recently, the lab has shifted focus from measuring the number of lncRNAs to finding lncRNAs that have a distinct biological function in human health and disease. One example of such a lncRNA is FIRRE, which is present in all animals, however the sequence is not conserved, except for in primates. FIRRE contains many interesting features, such as repeat sequences and CTCF binding sites. In absence of FIRRE, defects in the immune system can be observed and also some brain defects may also be observed.   References Carter, T., Singh, M., Dumbovic, G., Chobirko, J. D., Rinn, J. L., & Feschotte, C. (2022). Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo. eLife, 11, e76257. Advance online publication. https://doi.org/10.7554/eLife.76257 Long, Y., Hwang, T., Gooding, A. R., Goodrich, K. J., Rinn, J. L., & Cech, T. R. (2020). RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nature Genetics, 52(9), 931–938. https://doi.org/10.1038/s41588-020-0662-x Kelley, D., & Rinn, J. (2012). Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome biology, 13(11), R107. https://doi.org/10.1186/gb-2012-13-11-r107 Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., Regev, A., Lander, E. S., & Rinn, J. L. (2009). Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences, 106(28), 11667–11672. https://doi.org/10.1073/pnas.0904715106 Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., Cabili, M. N., Jaenisch, R., Mikkelsen, T. S., Jacks, T., Hacohen, N., Bernstein, B. E., Kellis, M., Regev, A., Rinn, J. L., & Lander, E. S. (2009). Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature, 458(7235), 223–227. https://doi.org/10.1038/nature07672   Related Episodes The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

नमस्ते दोस्तों! The Ranveer Show हिंदी के 96th Episode में आप सभी का स्वागत है. आज के Podcast में हमारे साथ जुड़ चुके हैं Para SF यानि Special Forces के जवान Major Sushant Singh जी, जो Traveller और Adventurer है। साथ ही में वे एक बेहतरीन Cyclist, Mountaineer और Martial Artist है। इस Podcast में हम बात करेंगे ढ़ेर सारी बातें Sushant जी के Early Life, Schooling, Azad Hind Sena के हिस्सा बने उनके Nanaji और Dadaji, NDA के Classes, Special Forces तक के सफर के बारे में। साथ ही साथ हम बात करेंगे Spiritual Life Of An Army Life, Agniveer Scheme, Agnipath, Future Of India Army, Terrorists In Himalayas और Himalayan Rescues के बारे में और भी ढ़ेर सारी बातें। मैं आशा करता हूँ कि ये Video आप सभी Viewers को पसंद आएगा। खास तौर पर उन सभी को जिन्हें Army Officers के Life के बारे में जानने में Interest है। What Is Agnipath Scheme, Bonding Between Army Officers, Leadership Qualities, Born Leaders, National Democratic Alliance और Border Security Force जैसी चीज़ों के बारे में हम Discuss करेंगे इस Hindi Podcast में सिर्फ और सिर्फ आपके Favourite BeerBiceps Hindi Channel Ranveer Allahbadia पर।

Peter Blachly (Blatchley) was a devotee of the man who called himself Yogi Bhajan from 1970 until 1987, when he was finally disillusioned by his close contact with YB and made a break from the organization. Peter was one of the early adopters of the Sikh religion, had an arranged marriage, two children who attended schools in India, and served as a “Singh Sahib” and member of the Khalsa Council until his departure in 1987.  Earlier, with Steve Josephs, then known as GuruShabad Singh, and Livtar, who is still in the cult, he formed the Khalsa String Band, published several albums of music, and took the band on a national tour in 1974-5.  Recordings of Peter's original songs are still played in Yoga classes around the world. He now lives in Bath, Maine with his wife, Johannah Harkness, a psychotherapist. He recently published book one of his two part memoir called, The Inner Circle, which documents his 17 year journey in detail.  Peter is happy to speak with anyone about his experience in 3HO.  Please reach out for his contact information.    You can DONATE to this broadcast at: http://www.gurunischan.com/uncomfortableconversations   Uncomfortable Conversations Spotify Playlist:  https://open.spotify.com/playlist/2lEfcoaDgbCCmztPZ4XIuN?si=vH-cH7HzRs-qFxzEuogOqg  

Shrimad Bhagwad Gita is the quintessence of Sanatana philosophy. It teaches us to face our fortunes and adversities with equanimity and fortitude. It seeks to engineer the nishkama samabuddhi yoddha in us, not the votary of Gandhian Ahimsa. Rajesh Kumar Singh joins Sanjay Dixit to bring the correct perspective to us.

I am joined by my good friend Nathan Singh, a freelance photographer and designer. In the podcast, we discussed mental health in men and why we don't always speak up, how I mentioned my food allergy when we first met, and different experiences we had together, such as eating out and the first time I gave a live talk about allergies. I hope you enjoy this podcast, if so please write me a review on iTunes I would really appreciate it.  Do you're food shopping online head over to FoodLama - https://bit.ly/3FBjR1U Thank you to Foodlama for sponsoring the podcast. FoodLama helps you with your grocery shopping online easier and safer, it's a google chrome extension that filters through your allergies or dietary requirements.  Follow Me: Instagram: https://www.instagram.com/_maycontain/ Twitter: https://twitter.com/_maycontain Blog: https://www.may-contain.com/ Sponsor: Food Lama - https://bit.ly/3FBjR1U

What is sacroiliac (SI) joint pain and how can you recognize it compared to normal back pain? In this episode we cover:   (1:15) what the sacroiliac joint is, (2:51) what SI joint pain feels like, (4:32) causes of SI joint pain, (7:15) diagnosing SI joint issues, (8:03) SI joint treatment,  and (12:11) preventing SI joint dysfunction. 

In this episode I sit down with Shamsher Singh and Baljit Singh to discuss the groundbreaking new documentary film, 'Battle of Amritsar (1984). We start with thoughts on how the documentary has been received before moving on to the issues of censorship and overcoming the challenges associated with that. We then look how and why 1984 remains this pivotal moment for Sikhs across the world and then spend some time discussing battle itself before moving on to the importance of honouring the sacrifices and achievements of the Khalsa, by centering the conversation on sovereignty and Khalistan.Be sure to hit subscribe and let us know your thoughts!You can find details of upcoming screenings at www.BattleOfAmritsar.com and follow the team on IG @nsyf_uk and for specific updates about the documentary follow @junghindpunjab

This week's episode is featuring Jennifer Singh, founder of She's Newsworthy Media. Jeniffer is a former TV reporter turned entrepreneur, speaker and CEO of She's Newsworthy Media. Before entrepreneurship, Jennifer worked in the Canadian media industry for over 15 years as a reporter, producer and writer for CTV, CBC, Global and CP24. She has been featured in the Globe and Mail, Toronto Star, Global News, CTV speaking and The Social speaking about imposter syndrome, women in business and the need for more inclusive marketing. Jennifer was also featured in a national campaign for International Women's Day in partnership with Mercedes-Benz Canada and Pink Tartan. She's Newsworthy Media was founded to help amplify the voices of women in the media because their expertise is underrepresented. The company is now Canada's go-to resource for women entrepreneurs who want to get massive exposure for their businesses on TV. The company has helped over 60 women entrepreneurs land media spots on the most popular Canadian TV shows including The Social, Cityline, CP24 Breakfast, Global News Morning and Your Morning. We discuss how Jennifer first got into the media industry & all the ups and downs that go on behind the scenes, the lack of representation in media and how she's working to change this by redefining PR, key tips & insights on how to actually get picked up by media outlets, and much more. Listen in to learn about: How to craft a newsworthy pitch that will actually get picked up by the media The key number of media outlets you should be sending your pitch to and how they determine this One common mistake made when doing PR as a business owner that will surprise you How to really utilize your earned media for your business & turn it into profit Resources: Website: https://www.shesnewsworthy.com/ Instagram: https://www.instagram.com/shesnewsworthy/ Waitlist for our signature PR program: https://www.shesnewsworthy.com/mediasuccess Our media pitch template: https://www.shesnewsworthy.com/mediapitchtemplate Newest resource, 20 media to pitch for maximum exposure: resources.shesnewsworthy.com/media She's Newsworthy Media Coaching: Media Success Coaching JOIN THE STEP-BY-STEP PODCAST LAUNCH PROGRAM: https://www.elevatepodcastco.com/courses Check It Out: Contracts Market: Affordable, customizable, Canadian contracts for your business Three Ships Beauty Code MADEITHAPPEN20 Powered by: Elevatepodcastco.com Start a podcast that stands out & amplifies your business! Connect With Us: Website: www.madeithappenpod.com/ Instagram: www.instagram.com/madeithappenpodcast/ LinkedIn: www.linkedin.com/company/made-it-happen-podcast

Veteran political analyst Pradeep Singh joins Sanjay Dixit to discuss the various aspect of the Maharashtra political crisis including the immaturity, inefficiency and misgovernance of Uddhav, his surrender to Left-liberal and the stellar role of Sanjay Raut.

Building a brand just online is not that easy. But this company, ViAct, a Construction Management Software, made it look very easy and simple. In this episode, Surendra Singh, ViAct's Marketing and Public Relations Lead, shares how their company built a brand online through SaaS marketing, and how they #getnoticed and got a 2-million dollar investment deal.Surendra also shares how ViAct can help construction companies, not just to monitor their operations, but to #getnoticed as well. He also explains how they are being noticed through their brand ambassadors, acquiring client feedback, sharing organically on social media and partnerships, and how they are contributing to ESG. Surendra also mentioned DingTalk, which is a communication tool they mainly use within all of their teams in 50 different locations.Post-production, transcript and show notes by XCD Virtual AssistantsBuild responsive quizzesGenerate higher quality, higher converting leadsVidyard - Use Video In Your EmailsVidyard is the easiest way to record and send videos that build personal connections.AI Writer - Content writing made easierGenerate Accurate, Relevant & Quality Content in 2 MinutesPeppertype - Virtual Content AssistantGenerate better content copies in seconds.If you want to know how to get noticed this show is for you. I have interviews, tools, tips, everything that an entrepreneur could need in order to help their organization to get noticed for free. Thank you for joining me on the unnoticed show.Buzzsprout - Let's get your podcast launched! Start for FREEPlease rate the show here.

By electing AAP three months ago, people of Punjab had shown they were fed up with the vicious power circle of BJP-SAD-Congress. They are now teaching AAP the same lesson. ----more---- https://theprint.in/opinion/simranjit-singh-mann-is-reborn-because-theres-an-uneasy-vacuum-in-punjab/1015190/ 

“The HrishiKay Sessions” are produced & presented by Hrishikesh Kannan popularly known as Hrishi K Thanks for listening. Should you want to experience more ….for starters hit “subscribe” / “follow” and check out more episodes & be notified when further sessions go up! If ur looking for Hrishi across media & social networking then here goes: Twitter : https://www.twitter.com/hrishikay Facebook : https://www.facebook.com/hrishikay Instagram : https://www.instagram.com/hrishikay Youtube : https://youtube.com/c/hrishikeshkannan Soundcloud : https://www.soundcloud.com/hrishikay LinkedIn : http://linkedin.com/in/hrishikay

Will Gates and Arthur Agee travel to Las Vegas to interview the founder of the St. Joe's Legacy Foundation, vascular surgeon, Dr. Tej Singh. When Will and Arthur's historical former high school, St. Joe's, closed down for good in 2021 Dr. Singh went to work buying the gym floor and all the memorabilia that went along with it and recreating a version of the gym in Las Vegas. Will and Arthur took a trip down memory lane as they sat with Dr. Singh on the very floor featured in the Hoop Dreams Documentary and where they and NBA Hall of Fame guard, Isiah Thomas, used to play basketball. They talked to Dr. Singh about what St. Joe's meant to them all as alumni and what Dr. Singh's vision is for the St. Joe's Legacy Foundation. Listen to a very special episode of Hoop Dreams The Podcast on the Unlearning Network. Available on Apple, Spotify, Google, YouTube or wherever you get your podcasts. This Special Episode was recorded on location in Las Vegas.Hosted by William Gates and Arthur Agee Created by Matt Hoffar, William Gates and Arthur Agee Written and Produced by Matt Hoffar Associate Producers: Matt Savage, Daniel Hernandez and Dennis Thompson Directed by Daniel Hernandez and Dennis Thompson Director of Photography Daniel Hernandez, Dennis Thompson and Dominic Edwards Hoop Dreams Theme Song by BlvecassoSound Engineering and Editing by Matt SavageField Producer: Chris VistoAn Unlearning Network and LVLS Creative Production www.unlearningnetwork.com

“The HrishiKay Sessions” are produced & presented by Hrishikesh Kannan popularly known as Hrishi K Thanks for listening. Should you want to experience more ….for starters hit “subscribe” / “follow” and check out more episodes & be notified when further sessions go up! If ur looking for Hrishi across media & social networking then here goes: Twitter : https://www.twitter.com/hrishikay Facebook : https://www.facebook.com/hrishikay Instagram : https://www.instagram.com/hrishikay Youtube : https://youtube.com/c/hrishikeshkannan Soundcloud : https://www.soundcloud.com/hrishikay LinkedIn : http://linkedin.com/in/hrishikay

“The HrishiKay Sessions” are produced & presented by Hrishikesh Kannan popularly known as Hrishi K Thanks for listening. Should you want to experience more ….for starters hit “subscribe” / “follow” and check out more episodes & be notified when further sessions go up! If ur looking for Hrishi across media & social networking then here goes: Twitter : https://www.twitter.com/hrishikay Facebook : https://www.facebook.com/hrishikay Instagram : https://www.instagram.com/hrishikay Youtube : https://youtube.com/c/hrishikeshkannan Soundcloud : https://www.soundcloud.com/hrishikay LinkedIn : http://linkedin.com/in/hrishikay

Today on SSONext, host Jordan Mullins sits down with Manisha Singh, the executive partner for talent transformation at IBM on how we can provide a better employee experience; and why it's so important. In a power-packed 20-minute conversation, Jordan and Manisha dig into:    ✅ Why employee experience is important to organizational success, ✅ What employee experience looks like in practice ✅ How it looks like at play on a day-to-day in hybrid versus in-office versus remote working models ✅ Manisha's inside-track sharing on what IBM is working on in the next five years from an employee experience perspective that other organizations can look to emulate. For the full details on that and a lot more,  listen to the episode   If you like what you hear today, do us a favour and hit the rating button to give us 5 stars. That way, we'll be seen in the systems, which will help us keep podcasting! 

Even in the face of hateful intolerance, Jagmeet Singh is taking the high road. The leader of Canada's New Democratic Party (NDP) recently attended the leadership convention for Nova Scotia's NDP. Ahead of the Saturday afternoon speech, Singh spoke to the issues facing our country right now including inflation (profiteering), the allegations of political interference in the Mass Casualty and of his own power within the dynamic of the supply and confidence agreement with Justin Trudeau's Liberal Party. He's confident the minority parliament will help us get better governance and he is attempting to do politics different. But it comes with a warning to the people who are ramping up the rhetoric that now seems tinged with violence being directed towards the people who hold elected office in this country. Here are 20 minutes of politics and democracy with Jagmeet Singh.

Jen talks to us about: How she went from finance to emerging technologies. What makes a good pitch. Why she loves helping entrepreneurs tell their stories. All that plus The Atlanta Favorites Quiz and much...

Building a brand just online is not that easy. But this company, ViAct, a Construction Management Software, made it look very easy and simple. In this episode, Surendra Singh, ViAct's Marketing and Public Relations Lead, shares how their company built a brand online through SaaS marketing, and how they #getnoticed and got a 2-million dollar investment deal.Surendra also shares how ViAct can help construction companies, not just to monitor their operations, but to #getnoticed as well. He also explains how they are being noticed through their brand ambassadors, acquiring client feedback, sharing organically on social media and partnerships, and how they are contributing to ESG. Surendra also mentioned DingTalk, which is a communication tool they mainly use within all of their teams in 50 different locations.Post-production, transcript and show notes by XCD Virtual AssistantsBuild responsive quizzesGenerate higher quality, higher converting leadsVidyard - Use Video In Your EmailsVidyard is the easiest way to record and send videos that build personal connections.AI Writer - Content writing made easierGenerate Accurate, Relevant & Quality Content in 2 MinutesPeppertype - Virtual Content AssistantGenerate better content copies in seconds.If you want to know how to get noticed this show is for you. I have interviews, tools, tips, everything that an entrepreneur could need in order to help their organization to get noticed for free. Thank you for joining me on the unnoticed show.Buzzsprout - Let's get your podcast launched! Start for FREEPlease rate the show here.

Have you ever heard of the term craniofacial development? Does it relate to how well we breathe and sleep? How about cleft lip and palate? Well, today we are going to be exploring these fascinating topics. My guest today is Professor Dave Singh. Professor Dave Singh is a US citizen who was born, educated and trained in England, UK. He holds three doctorates, including a Doctor of Dental Medicine; a PhD in cleft palate development, and a third Doctorate in Orthodontics. Dr Singh was the Founder and Chief Executive Officer of BioModeling Solutions, Inc. He has published over 200 articles in the peer-reviewed medical, dental and orthodontic literature, has published 7 books/chapters, and is currently finishing his new book entitled “Pneumopedics and craniofacial epigenetics.” Join me in this episode as we tackle craniofacial development, cleft lip and palate, epigenetics, the importance of nitric oxide, and so much more. ----  CREDITS: Host: Dr Ron Ehrlich Guest: Prof Dave Singh Producer: Amelia Navascues ----  You can also watch this episode at https://drronehrlich.com/ ----- TIME TO TAKE CONTROL OF YOUR HEALTH? Join me in my online health programs.  ----- CONNECT WITH ME You can ask questions via social media using my Instagram or Facebook or TikTok or YouTube page. See omnystudio.com/listener for privacy information.

Defection in politics predates Gaya Lal -- the Haryana MLA who switched party thrice in a day in 1967. After finally securing his loyalty, senior Congress leader Rao Birender Singh had then famously told a press conference in Chandigarh, ‘Gaya Ram ab Aaya Ram hai'. Little did Singh know that the phrase, with some changes in word orders, will turn into a cliché in Indian politics. About 18 years later, In 1985, in a bid to curb defection, the then Rajiv Gandhi government had brought the anti-defection law through the 52nd Amendment Act of 1985. This amendment is known as anti-defection law. An anti-defection law calls for disqualification of elected representatives if they switch political parties on the lure of executive office or other gains. The aim is to bring political stability and demand accountability from the legislatures. Under the anti-defection law, members of a political party can be disqualified and removed from the membership of the House if they voluntarily resign from the party after being elected or defy the direction or whip of the party leadership in the House. Independent lawmakers may also stare at disqualification for switching political parties. However, if two-thirds of members of a political party intend to shift to another party, the law exempts them from disqualification. In 2021, 12 out of 17 Congress MLAs jumped ship to join Trinamool Congress in Meghalaya and were exempted from the anti-defection law. Despite the anti-defection law, political defections are a common phenomenon and related proceedings have been going on in various courts. The role of the adjudicating authority --- usually the speaker of the House --- is under scrutiny in most of the anti-defection cases. There were several instances of delays in the disqualification process as the speaker is not time bound to decide on any case. For instance, during 2014-18, multiple opposition MLAs defected to the ruling TRS party and no action was taken by the speaker against these defectors. Experts argue that the speaker may not be the objective authority to decide on anti-defection cases. And also, the whip of a political party forces lawmakers to toe the party line and undermines their judgement on important issues. This essentially kills inner-party democracy. Given numerous loopholes, experts have urged the government to revisit and reform the anti-defection law.  

Want to learn the secrets to business success from company owners who are not only surviving but thriving in this difficult economy? Then join award-winning entrepreneur Mike Bosma and his guests as they provide you with the insight and expertise you need to start a new business or to take your company to a whole new level. In between jobs? Why work for the boss when you can be the boss? With Bosma On Business you can be in conversation with the area's top corporate executives, community leaders and movers and shakers. The show is the ultimate business networking event and entrepreneurial incubator wrapped up in one and it's brought to you live weekly over the airwaves and through the Internet. You'll tap into a wealth of wisdom from top experts in the fields of accounting, marketing, sales, information technology, business law, human resources, corporate real estate, banking and so much more. If you're doing business in Northern Nevada or have the entrepreneurial itch, then plan on joining us on News Talk 780 KOH every Saturday morning at 10 a.m. With Mike Bosma, the Pied Piper of entrepreneurial excellence leading the way, we're Getting Northern Nevada…Back to Business. See omnystudio.com/listener for privacy information.

A University of Arizona-led team of astronomers has created a detailed, three-dimensional image of a dying hypergiant star. The team, led by UArizona researchers Ambesh Singh and Lucy Ziurys, traced the distribution, directions and velocities of a variety of molecules surrounding a red hypergiant star known as VY Canis Majoris. Their findings, which they presented on June 13 at the 240th Meeting of the American Astronomical Society in Pasadena, California, offer insights, at an unprecedented scale, into the processes that accompany the death of giant stars. The work was done with collaborators Robert Humphreys from the University of Minnesota and Anita Richards from the University of Manchester in the United Kingdom. Extreme supergiant stars known as hypergiants are very rare, with only a few known to exist in the Milky Way. Examples include Betelgeuse, the second brightest star in the constellation Orion, and NML Cygni, also known as V1489 Cygni, in the constellation Cygnus. Unlike stars with lower masses – which are more likely to puff up once they enter the red giant phase but generally retain a spherical shape – hypergiants tend to experience substantial, sporadic mass loss events that form complex, highly irregular structures composed of arcs, clumps and knots. Located about 3,009 light-years from Earth, VY Canis Majoris – or VY CMa, for short – is a pulsating variable star in the slightly southern constellation of Canis Major. Spanning anywhere from 10,000 to 15,000 astronomical units (with 1 AU being the average distance between Earth and the sun) VY CMa is possibly the most massive star in the Milky Way, according to Ziurys. “Think of it as Betelgeuse on steroids,” said Ziurys, a Regents Professor with joint appointments in UArizona Department of Chemistry and Biochemistry and Steward Observatory, both part of the College of Science. “It is much larger, much more massive and undergoes violent mass eruptions every 200 years or so.” The team chose to study VY CMa because it is one of the best examples of these types of stars. “We are particularly interested in what hypergiant stars do at end of their lives,” said Singh, a fourth-year doctoral student in Ziurys' lab. “People used to think these massive stars simply evolve into supernovae explosions, but we are no longer sure about that.” “If that were the case, we should see many more supernovae explosions across the sky,” Ziurys added. “We now think they might quietly collapse into black holes, but we don't know which ones end their lives like that, or why that happens and how.” Previous imaging of VY CMa with NASA's Hubble Space Telescope and spectroscopy showed the presence of distinct arcs and other clumps and knots, many extending thousands of AU from the central star. In Search of Details on the Deaths of Rare Giant Stars To uncover more details of the processes by which hypergiant stars end their lives, the team set out to trace certain molecules around the hypergiant and map them to preexisting images of the dust, taken by the Hubble Space Telescope. “Nobody has been able to make a complete image of this star,” Ziurys said, explaining that her team set out to understand the mechanisms by which the star sheds mass, which appear to be different from those of smaller stars entering their red giant phase at the end of their lives. “You don't see this nice, symmetrical mass loss, but rather convection cells that blow through the star's photosphere like giant bullets and eject mass in different directions,” Ziurys said. “These are analogous to the coronal arcs seen in the sun, but a billion times larger.” The team used the Atacama Large Millimeter Array, or ALMA, in Chile to trace a variety of molecules in material ejected from the stellar surface. While some observations are still in progress, preliminary maps of sulfur oxide, sulfur dioxide, silicon oxide, phosphorous oxide and sodium chloride were obtained. From these data, the group constructed an image of the gl...

“The HrishiKay Sessions” are produced & presented by Hrishikesh Kannan popularly known as Hrishi K Thanks for listening. Should you want to experience more ….for starters hit “subscribe” / “follow” and check out more episodes & be notified when further sessions go up! If ur looking for Hrishi across media & social networking then here goes: Twitter : https://www.twitter.com/hrishikay Facebook : https://www.facebook.com/hrishikay Instagram : https://www.instagram.com/hrishikay Youtube : https://youtube.com/c/hrishikeshkannan Soundcloud : https://www.soundcloud.com/hrishikay LinkedIn : http://linkedin.com/in/hrishikay

Episode 1877: Our article of the day is Navdeep Singh (Ashok Chakra).

Pavitra Singh currently heads HR for PepsiCo India. She has been with PepsiCo for the last 15+ years. With 20 years of work experience leading large teams across geographies, she has held leadership positions across a variety of roles in India and other markets. From Center of excellence roles like Talent Management, L&D, Culture, D&I, and Talent Acquisition to operating HR Business partnering roles.Prior to joining PepsiCo, she worked with American Express and Fair Isaac.Pavitra is an explorer at heart. She loves traveling the world and experiencing different cultures. A Gen Z mom, she loves spending time with her daughter and learning from her new age methods.Timestamps Leading with HEART -  2:30Location free roles - 9:18Running your own race - 19:30Celebrating failures - 22:45Culture Transformation - 28:52QuotesIf you trust your employees they are going to give their bestYou learn and pick up different things from different leadersAlways believe in running your own raceIf the values are strong, there is no “grey”You live to work and not work to liveCulture is the “Smell” of the placeConnect with Pavitra:  LinkedInDo not miss to check out our new website and share your love https://inspiresomeonetoday.in/Subscribe, follow, and leave your comments to help me get better with my episodes. Available on all podcast platforms, including, Google Podcasts, Apple Podcasts, YouTube, Spotify, Stitcher, Castbox, RadioPublic, TuneIn, Gaana Jio Saavn, AudibleDo stay tuned for new episodes every alternate Friday. Next episode - Jul 8'22.

Mr. Singh explains how he's able to keep gas prices significantly lower than other gas stations.  See omnystudio.com/listener for privacy information.

How do you prepare for Data Science interviews in Tech? What are the components of the interview and what resources should you use? What do Hiring Managers look for in a candidate? And what's the point of behavioral questions in a data science interview? Find out answers to all of the above and more in this discussion with Nick Singh, Author of Ace the Data Science interview and former data scientist and engineer at Google and Facebook, and Roy Keyes, Author of Hiring Data Scientists and ML Engineers. Thanks for listening! You can subscribe to our newsletter on our website at www.learneducatediscover.com/ You can email us at hello@learneducatediscover.com Follow us on Twitter @LED_Curator Nick's book Ace the Data Science interview: https://www.acethedatascienceinterview.com/ Roy's book Hiring Data Scientists and Machine Learning Engineers: https://dshiring.com/

Guru Govind Singh Ji -2 : Manoj Bhai Gurubhaktiyoga

This week's episode features Chinese-Canadian Breathwork Coach & Intuitive Guide, Christine Lu Singh. We talk about all things breathwork. She shares about her transition from her corporate PR job into being a breathwork facilitator. She talks about the divide she felt between her soul and her ego before she made the leap into her new career. And she also shares how to gently move through trauma using breathwork. We then shift to talk about her process of co-authoring a book while pregnant. I thoroughly enjoyed this conversation and highly recommend it for anyone that is interested in embodiment tools. Follow Christine Lu Singh on Instagram: https://www.instagram.com/breathewithtine/ (@breathewithtine) Visit Christine Lu Singh's website: https://www.breathewithtine.com/ (https://www.breathewithtine.com/) Follow Lit AF on Instagram: https://www.instagram.com/itsmesarahcohan/ (@itsmesarahcohan.com) Visit the Lit AF Website: https://www.sarahcohan.com/ (https://www.sarahcohan.com/) Thank you so much for listening. Please leave a rating and a review for the Lit AF podcast. This really helps to grow the Lit AF community. And please share this episode with your friend, it will make them feel good. Are you loving the Lit AF podcast? Make a one-time or recurring donation to thehttps://www.sarahcohan.com/tipjar ( tip jar) to support the show. THANK YOU. Additional resources from Christine Lu Singh:  Coach for Transformation & Healing: I am launching a very limited 1:1 private coaching offering where you will have access to healing modalities such as Intuitive Readings, Breathwork and Distance Energy Healing Sessions (Reiki). Over the course of three months, you will be held in a sacred container for your healing and transformation journey. You will not be the same after this experience. If you feel a nudge and that this might be for you, let's chat: https://breathewithtine.as.me/claritycall (https://breathewithtine.as.me/claritycall) Connect with Me: I invite you to follow me on Instagram @breathewithtine and join my mailing list for the occasional love note to stay updated on upcoming events and all the magical things. Email me at hello@breathewithtine.com and I'll send you a mini guided Breathwork session (10 min) you can use for your own practice. It can be a very powerful practice done daily, or in moments when you need to slow down and get back to your center.  SOLD OUT! REIMAGINE Summer Mini Retreat: I'm cohosting an intimate mini retreat on July 13 from 2pm - 5pm PT in a secret healing garden in San Francisco where you'll be guided through a limiting belief workshop, a goal and intention setting to create a 90 day action plan followed by my signature Breathwork & Reiki experience to embody the new you. We sold out for our Summer edition! Due to the popular demand, we are already planning our next retreat for Fall 2022. Send me an email at hello@breathewithtine.com if you'd like to be put on the list for more info.  Private Sessions: If you're interested in deepening your practice with Breathwork and/or Reiki, I offer private 1:1 sessions for individuals, couples and groups. Learn more about my offerings here: https://breathewithtine.as.me/ (https://breathewithtine.as.me/)

Responding to the crisis of medical burnout, Punit Singh Soni, a former product manager at Google, launched the company Suki with a specific goal: leverage the burgeoning field of voice technology to lessen the growing administrative burden on clinicians. Soni says enterprise contexts, and healthcare in particular, are well-suited for the next generation of assistive voice-activated software. “Whatever you're going to do in medicine is going to be interwoven with technology in the near future,” he tells host Shiv Gaglani. But as the rickety state of so much current healthcare administrative technology suggests, the prevailing cultures in the tech and medical worlds do not easily mix. Rather than trying to reshape how doctors do their job, Soni seeks to meet doctors where they already are, seamlessly integrating a voice system into the fabric of their work so they can spend more time caring for patients. Tune in to hear about why “the biggest technology company ever built is going to be in healthcare,” and how a user-centric mindset can help you not just build a company, but craft a career.

This week, Tayo welcomes TikToker, public speaker, and poet, Nav Singh, to the podcast to talk about his career, the world of poetry, and Sikhism. Nav opens up the episode by recalling his first time performing his poetry and just how life changing this moment was, as he fell in love with poetry and began to perform his own more often. While this experience helped teach him to have a 'thick skin', it wasn't until he joined TikTok, that he learned how to deal with online hate and opinions. Nav doesn't let this get to him though. He's doing what he loves, and he's grateful for that opportunity in the first place.He and Tayo go on to talk about the importance of following your flame - after all, Nav would find it more difficult to bear the brunt of online hatred if he wasn't so passionate about what he has to say on TikTok. Now, he's learned to handle online hate with grace. That's not to say, however, that Nav doesn't receive positive feedback; he does and overwhelmingly so. In fact, he closes out today's episode by talking about the power of sharing with others. After all, one of the most beautiful things he gets to experience as a poet and TikToker is the unique moment where people share their vulnerable stories because he was willing to do the same with them.The Finer Details of This Episode:Joining the world of poetry The first time Nav performed his poetry Dealing with what other people think Sharing his Sikh faith on TikTok Following your flame Handling online hate The importance of critical thinkingLinks:Connect with Nav:Nav's TikTokRooted in Sikh PodcastConnect with Tayo Rockson and the As Told By Nomads Podcast:Tayo's WebsiteTayo on LinkedIn Tayo on TwitterTayo on YouTubeTayo on TikTokAs Told by Nomads PodcastUYD ManagementUYD Collective See acast.com/privacy for privacy and opt-out information.

Guru Govind Singh Ji -1 : Manoj Bhai Gurubhaktiyoga

Welcome to a new episode of Get Real with Kacey Kasem… the podcast that takes a deep look into the minds of creators in the fantasy football space.  In this episode, I talked with Kelly Singh, someone you may know from Team Rise or Fall, Women of Fantasy Football, Extra Points with Kelly in Phoenix, Woodward Bets, thecommishbrand.com, In-Between Media, Trophy Smack, and more. We talked about her love of golf, writing lifestyle content, sharing personal experiences in her writing, her NFL Draft experience, her “job-job” at Trophy Smack, and tons more.   Give Kelly a follow on Twitter @KellyInPhoenix.  You can find me on Twitter @thekaceykasem and the podcast @GetReal_Pod.  This podcast is also a proud member of DAP Network.  Thank you so much for tuning in, and enjoy this episode with Kelly Singh.   Theme Song by Audionautix   Thank you so much to TrophySmack for being an affiliate of Get Real with Kacey Kasem.  This is the spot to check if you are looking for fantasy football trophies, belts, rings, draft boards, etc.  I have an affiliate link: https://www.trophysmack.com?afmc=GETREALPOD you can check out in order to view all the rad items they have there.  Free shipping.  Free engraving.  100% satisfaction guaranteed.  I've been a fan of theirs for a while, and they are definitely good people over there.   Make sure to use the discount code GETREALPOD for a free ring with the purchase of a trophy or belt.  Note that you must have BOTH the trophy or belt PLUS the ring in your cart for the discount.  Live draft season is upon us, so what are you waiting for.     Drizly (21+ only): https://drizly.sjv.io/c/3450932/841291/9425   3Chi (21+): https://www.3chi.com/?rfsn=6579433.30d91d   E-mail Kacey - kaceykasemff@gmail.com or DM me on Twitter @thekaceykasem with any business inquiries or just to say howdy.  Thank you for a 5 star rating (if you feel like helping the show even more).   #fantasyfootball #fantasyanalyst #contentcreator #interview   Tags: fantasy sports, fantasy football, broadcasting, youtube, podcasting, writing, writers, sports, podcasts, dynasty fantasy football, redraft fantasy football, analysts, content creators, how to, advice, fantasy football industry, tiktok, twitter, interview, interviews, ff, creators, learning  

Welcome to a new episode of Get Real with Kacey Kasem… the podcast that takes a deep look into the minds of creators in the fantasy football space. In this episode, I talked with Kelly Singh, someone you may know from Team Rise or Fall, Women of Fantasy Football, Extra Points with Kelly in Phoenix, Woodward Bets, thecommishbrand.com, In-Between Media, Trophy Smack, and more. We talked about her love of golf, writing lifestyle content, sharing personal experiences in her writing, her NFL Draft experience, her “job-job” at Trophy Smack, and tons more. Give Kelly a follow on Twitter @KellyInPhoenix. You can find me on Twitter @thekaceykasem and the podcast @GetReal_Pod. This podcast is also a proud member of DAP Network. Thank you so much for tuning in, and enjoy this episode with Kelly Singh. Theme Song by Audionautix Thank you so much to TrophySmack for being an affiliate of Get Real with Kacey Kasem. This is the spot to check if you are looking for fantasy football trophies, belts, rings, draft boards, etc. I have an affiliate link: https://www.trophysmack.com?afmc=GETREALPOD you can check out in order to view all the rad items they have there. Free shipping. Free engraving. 100% satisfaction guaranteed. I've been a fan of theirs for a while, and they are definitely good people over there. Make sure to use the discount code GETREALPOD for a free ring with the purchase of a trophy or belt. Note that you must have BOTH the trophy or belt PLUS the ring in your cart for the discount. Live draft season is upon us, so what are you waiting for. Drizly (21+ only): https://drizly.sjv.io/c/3450932/841291/9425 3Chi (21+): https://www.3chi.com/?rfsn=6579433.30d91d E-mail Kacey - kaceykasemff@gmail.com or DM me on Twitter @thekaceykasem with any business inquiries or just to say howdy. Thank you for a 5 star rating (if you feel like helping the show even more). #fantasyfootball #fantasyanalyst #contentcreator #interview Tags: fantasy sports, fantasy football, broadcasting, youtube, podcasting, writing, writers, sports, podcasts, dynasty fantasy football, redraft fantasy football, analysts, content creators, how to, advice, fantasy football industry, tiktok, twitter, interview, interviews, ff, creators, learning --- Support this podcast: https://anchor.fm/getrealpod/support

When you feel a burning pain around your joints, how do you know if it's acute tendonitis or the chronic issue of tendonosis? Dr. Singh covers both conditions as well as how to diagnose and treat these issues. We also cover: (1:26) distinguishing between tendonitis and tendonosis, (4:42) diagnosing tendonitis and tendonosis, (7:14) treatment options, (8:48) importance of stretching and ice, and (10:37) interventional options.

Progressive promos and large noises coming from an artist in a small country… It's been a busy few weeks for DJ Dan Singh as he continues his work for us and for Blast Radio. In this edition of CFRS he's been swamped with more promos because you progressive producers out there keep making music! and […]

In part 2 of the Sant Baba Attar Singh Ji podcast, we learn about the immense level of respect Sant Ji received from people from all walks of life, Even Royalty! We look at key points in their life, such as when Sant Ji went to prison, having darshan of the Gurus, completing Akhand Paaths on their own, and so many life lessons that we can take away and incorporate into our own lives. This podcast is full of inspirational stories that can allow so many of us to progress spiritually. A special thanks to Ustaad Jivanpaal Singh Ji of Nihung Santhia for sharing the Jeevan (Life) of Sant Baba Attar Singh Ji Mastuana Wale. If you missed Part 1 of this podcast, watch it here: https://youtu.be/xGPd8rQTlU8 Don't forget to share this podcast with your friends and family! #SantBabaAttarSinghJi #Sikh #InspirationalStories ——————————————————

Women and girls are conditioned to believe success is "a seat at the table." Creator, actress and author Lilly Singh thinks we need to build a better table. In this hilarious, incisive talk, Singh traces the arc of her career from up-and-coming YouTuber to history-making late-night talk show host, offering four ways to build a more inclusive society where girls are encouraged and empowered to do great things. After the talk, our host Modupe shares telltale signs a workspace isn't built with everyone in mind – and how small changes can make a big impact on making all people feel welcome. We love making TED Business, and we want to make it better. So if you have a few minutes, share your thoughts at surveynerds.com/ted

Dr. Jaspal Ricky Singh is Vice Chair & Associate Professor in the Department of Rehabilitation Medicine at Weill Cornell Medical College of New York-Presbyterian Hospital. He is a triple-board certified physician specializing in Physical Medicine and Rehabilitation, Sports Medicine and Pain Medicine. Dr. Singh specializes in a multidisciplinary approach to treat pain by integrating physical therapy and interventional techniques into his care. Through the use of minimally invasive, fluoroscopic-guided spine procedures, peripheral nerve blocks, electrodiagnostics and musculoskeletal ultrasound, Dr. Singh individualizes his treatment plan with a focus on functional restoration.Dr. Singh has been honored as Super Doctors- New York Rising Star, New York's Top Doctors in Pain Medicine and America's Best Doctor by Castle Connolly.He has a comprehensive website where you can learn more about him at rickysinghmd.com and make sure to tune into his podcast called The Back Story.In this episode we discuss:Causes of low back pain.Treatment options for low back pain.The importance of core strength in preventing and treating back pain.How  to best work your core.Boutique fitness.The importance of recovery.Are there exercises you should never do?Protecting your spine.  Learning what your body needs.The podcast episodes drop weekly on Monday over the summer. Subscribe to stay up to date, and tune in when you can! Be sure to rate, review, and follow on your favorite podcast app and let me know what other brain & body things you'd like to hear about. For more information about me, check out my website.Follow me on Instagram, Twitter, or Tik Tok @drnatashamehta. This episode is not sponsored.

Nninja Singh is an Indian model and the founder of Ninjas Model Management ,India. She won Ford SuperModel India in 2010 and moved to New York. She appeared on many magazine covers like Elle, Marie Claire, Vogue to name a few. She represent face & diversity in many campaign and appeared in L'Oréal true beauty ads. Her experience of being a fashion model as well as voice for women within fashion world and society has truly made her exceptional role model for younger generations. She is founder of Nninjas Model agency where everyday face became face of fashion world. While changing the industry norm of being model, she is pursuing her Law degree. Her wisdoms and knowledge about her career pays pivot role for every young women & men who desired to be next face from India & of India. Her agency plays true meaning of equality & mission to pay back to the society by scouting her true talent had shaken up modeling agency within India. Now, Nninjas Models are ruling the modeling world by creating a platform of fashion where all different parts of the world can come together under one culture which is living life with a purpose. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

------------------Support the channel------------ Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuy PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Manvir Singh is Postdoctoral Research Fellow at the Institute of Advanced Study in Toulouse. His research program aims to explain why societies develop complex, recurrent traditions such as shamanism, witchcraft, origin myths, property rights, sharing norms, lullabies, dance, music, and gods, as these have appeared in all types of societies across the globe, from nomadic hunter-gatherer bands to complex, industrial, mega-urbanized states. In this episode, we talk about a recent paper of his, “Human social organization during the Late Pleistocene: Beyond the nomadic-egalitarian model”. We break down the nomadic-egalitarian hunter-gatherer model. Dr. Singh presents his diverse histories model, and we discuss the implications it has for our evolved psychology, and how we think about evolutionary mismatches. We discuss how human societies get organized, the origins of agriculture, the transition to large-scale agricultural societies, and non-agricultural state societies. We also talk about the sympathetic plot in fiction, and its psychological origins. Finally, we discuss how to think about the functionality of beliefs. -- A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: KARIN LIETZCKE, ANN BLANCHETTE, PER HELGE LARSEN, LAU GUERREIRO, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, HERBERT GINTIS, RUTGER VOS, RICARDO VLADIMIRO, CRAIG HEALY, OLAF ALEX, PHILIP KURIAN, JONATHAN VISSER, JAKOB KLINKBY, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, PAULINA BARREN, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ARTHUR KOH, ZOOP, MARCO NEVES, COLIN HOLBROOK, SUSAN PINKER, PABLO SANTURBANO, SIMON COLUMBUS, PHIL KAVANAGH, JORGE ESPINHA, CORY CLARK, MARK BLYTH, ROBERTO INGUANZO, MIKKEL STORMYR, ERIC NEURMANN, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, BERNARD HUGUENEY, ALEXANDER DANNBAUER, FERGAL CUSSEN, YEVHEN BODRENKO, HAL HERZOG, NUNO MACHADO, DON ROSS, JONATHAN LEIBRANT, JOÃO LINHARES, OZLEM BULUT, NATHAN NGUYEN, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, J.W., JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, IDAN SOLON, ROMAIN ROCH, DMITRY GRIGORYEV, TOM ROTH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, AL ORTIZ, NELLEKE BAK, KATHRINE AND PATRICK TOBIN, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, NICK GOLDEN, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS P. FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, DENISE COOK, SCOTT, ZACHARY FISH, TIM DUFFY, TRADERINNYC, AND MAX BEILBY! A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, IAN GILLIGAN, LUIS CAYETANO, TOM VANEGDOM, CURTIS DIXON, BENEDIKT MUELLER, VEGA GIDEY, THOMAS TRUMBLE, AND NUNO ELDER! AND TO MY EXECUTIVE PRODUCERS, MICHAL RUSIECKI, ROSEY, JAMES PRATT, MATTHEW LAVENDER, SERGIU CODREANU, AND BOGDAN KANIVETS!

Hey Guys! This week we have Jay Singh III from specialsitsresearch.com. This episode is all about special situation and our guest Jay shares with us his investing journey and how he got to work in Goldman Sachs, why every investment is a factor bet, what is the Church of What is Known, why SPACs are one of the best opportunities to exist for the short side and the long side, what is the risk and reward for investing in the energy sector and how to screen for ideas. If you enjoyed this podcast, check out Jay on Twitter here. And make sure to read his research here. Check out the timestamp below: [0:00] Every Investment is a Factor Bet [6:00] The Church of What is Working Now. [12:00] TAMs larger than the Gobal Economy [15:00] 33 Fintech SPAC Mergers [21:00] Jay Singh III Investment Journey [30:00] SPACs are One of the Best Opportunities to Exist [1:02:00] Using Screens to Find Idea [1:11:00] Investing in Energy [1:20:00] Closing Question and more from Jay Singh III Finally, a big thanks to the following sponsors for making the podcast a reality. Mitimco This episode is brought to you by MITIMCo, the investment office of MIT. Each year, MITIMCo invests in a handful of new emerging managers who it believes can earn exceptional long-term returns in support of MIT's mission. To help the emerging manager community more broadly, they created emergingmanagers.org, a website for emerging manager stockpickers. For those looking to start a stock-picking fund or just looking to learn about how others have done it, I highly recommend the site. You'll find essays and interviews by successful emerging managers, service providers used by MIT's own managers, essays MITIMCo has written for emerging managers and more! Quartr Quartr is revolutionizing the way investors interact with IR departments, listen to conference calls, and engage in investment research. The best way to think of Quartr is like Spotify for investor conference calls. Quartr is 100% free and includes markets from 12+ countries (with plans to expand in the future!). Investors can easily request new companies, and Quartr is quick to add them. You can learn more about Quartr by visiting their site, Quartr.se If you're interested in changing the way you research companies, download the app today and give it a try on Apple and Android. Tegus Tegus has the world's largest collection of instantly available interviews on all the public and private companies you care about. Tegus actually makes primary research fun and effortless, too. Instead of weeks and months, you can learn a new industry or company in hours, and all from those that know it best. I spend nearly all my time reading Tegus calls on existing holdings and new ideas. And I know you will too. So if you're interested, head on over to tegus.co/valuehive for a free trial to see for yourself. TIKR TIKR is THE BEST resource for all stock market data, I use TIKR every day in my process, and I know you will too. Make sure to check them out at TIKR.com/hive. --- Support this podcast: https://anchor.fm/valuehive/support

Episode 98: Apretude and code blue. Apretude is a new injectable medication for HIV pre-exposure prophylaxis (PrEP), Dr. Yomi presents how to use it. Then, Mandeep, Jon, and.  Introduction: Apretude, a new injectable for HIV PrEP.  By Timiiye Yomi, MD. Moderated by Jennifer Thoene, MD.   What is HIV PrEP? Pre-exposure prophylaxis (or PrEP) consists of taking medication when a patient has a high risk of contracting HIV to lower their chances of getting infected.  Who can take HIV PrEP? Individuals who may benefit from PrEP include but are not limited to: Male who have sex with male (MSM), people with multiple sexual partners with no consistent use of condoms, or people who have been diagnosed with an STD in the past 6 months, IV drug users who share needles, syringes, or other injection equipment. History of HIV PrEP: In 2012, the first medication for HIV PrEP was approved—Truvada® (tenofovir-emtricitabine). Truvada is a once-daily oral prescription drug. Seven years later, in 2019, the next medication for HIV PrEP was approved— Descovy® (tenofovir alafenamide and emtricitabine). It is also a daily PO medication. But today we want to introduce you to the newest medication for HIV PrEP—Apretude® (cabotegravir). On Dec 20, 2021, FDA approved Apretude (cabotegravir), an extended-release injectable for HIV-1 pre-exposure prophylaxis for at-risk adolescents and adults who weigh at least 35 kg (77 lbs). Mechanism of action: Apretude is a long-acting integrase inhibitor that works by binding to the HIV integrase active site and blocking the strand transfer step of retroviral DNA integration. How is it given? Comes as a 600-mg (3-mL) injection. Patients receive 2 initiation injections administered 1 month apart, thereafter every 2 months. Patients can start medication immediately or first take the oral formulation for 4 weeks to assess how well they tolerate the medication before beginning the injection. Trials: The safety and efficacy of Apretude in reducing the risk of contracting HIV-1 were evaluated in two randomized double-blind trials comparing Apretude and Truvada (once-daily oral medication).Trial 1: Participants who took Apretude had a 69% less risk of contracting HIV compared to Truvada.Trial 2: Participants who took Apretude had a 90% less risk of contracting HIV compared to Truvada. Common side effects: Fever, malaise, fatigue, sleep problems, myalgias and arthralgias, headache, rash, red and swollen eyes, edema of face, lips, mouth, tongue; GI discomfort, hepatotoxicity, and depression. Note: Some drug-resistant HIV variants have been identified in people with undiagnosed HIV prior to beginning Apretude. People who test positive for HIV while on Apretude must transition to a complete HIV treatment regimen as Apretude is not approved for HIV treatment.  Requirements to receive Apretude: -Patient must be HIV-1 negative-Patient must remain negative to continue receiving Apretude-Patient must not miss any injections as this increases their risk of contracting the virus Apretude does not protect against other sexually transmitted infections. Patients must be sexually responsible and use other forms of protection such as condoms during sexual intercourse. This is the Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.___________________________A code blue in clinic.  By Manpreet Singh, MS3; Jon-Ade Holter, MS3; and Sheinnera Gerongay, MS3. Ross University School of Medicine. What is a code blue?Arreaza: Today we will present to you a case to remind you about some principles of cardiopulmonary resuscitation (CPR). The term “code blue” in the United States refers to a situation where a patient is in cardiac arrest, respiratory arrest, unresponsive, or experiencing another medical emergency that requires immediate attention. “Code blue” is commonly used in hospitals and clinics to call a rapid response team to arrive immediately to evaluate the patient. We hope you can benefit from this brief review and feel ready for your next code blue. Of course, you will need more than we provide during these few minutes, but we hope it triggers your curiosity to keep learning or practicing. By the way, “code blue” is not standard for medical emergency in the whole world. For example, in the United Kingdom, they call it “code red”. Case presentation: Mr. DD 56-year-old man with a past medical history of coronary artery disease, recent MI, DM2, and CHF presents today to our clinic for hospital follow. He had an MI 2 weeks ago. He reports that when he was at home working in the yard, he suddenly had 8/10 retrosternal chest pain, pressure-like, accompanied by shortness of breath and diaphoresis. The pain radiated to the left side of his neck/jaw and down his left shoulder and arm. Jon: Nitroglycerin was taken by Mr. DD 3 times without resolution of symptoms. The patient was taken by EMS to Kern Medical ER. In the hospital, there was a 4mm ST elevation on ECG on leads II, III, and aVF. Q waves were also seen in anterior leads V4-V6. Patient was taken to cath lab and stent was placed in the RCA. ECHO showed decreased left ventricle wall motion and dilated left ventricle with an ejection fraction of 28%. Mr. DD was discharged after 5 days in the hospital.M: He is currently on lisinopril, carvedilol, atorvastatin, aspirin, clopidogrel, metformin, and digoxin. He states he is not compliant with all the medications because he forgets to get refills at times. He has a 35-pack year history of smoking and drinks 3-4 4oz drinks every day after work. He states he has used methamphetamine and cocaine intermittently within the last 6 months.J: Today, he lets the MA know that he is having some chest pain at night, shortness of breath with minimal activity for the last week, and at times he feels his heart is beating too fast. He has a follow-up appointment with cardiology in 2 weeks. The MA tells you that the patient vitals today are BP:195/105, HR: 108, RR: 28, and O2% 89% on room air. M: You are reviewing the patient's chart when you hear a loud thud coming from the room, you rush into the room and find the patient on the ground. The patient is unresponsive and is not moving. What is your next action? A. Try to lift the patient off the ground and back onto the chair or bed B. Give the patient nitroglycerin sublingually C. Call and wait for the EMS before proceeding D. Obtain IV accessE. See if the patient is arousable and check pulse and breathing E is the correct answer to this question because before initiating any type of treatment, first, you must assess the patient for alert response and their basic vitals such as their pulse and breathing.J: We do this because we need to know if the cardiopulmonary systems are intact. When they are not intact, regardless of the level of medical training, we must start CPR protocol. M: This patient most likely suffered a tachyarrhythmia, a very common post-MI-complication that causes the highest mortality rates. The most common cause of death are ventricular fibrillation and ventricular tachycardia. J: These are the steps we must take in order to start resuscitation of the cardiopulmonary system in any environment before the patient can be taken to a higher level of care. In this situation, Doctor Holter and Doctor Singh will perform 2-patient CPR. This is only an introduction of basic life support and advanced cardiac life support. You will need additional training to get the BLS and ACLS certificates. M: First, assure your environment is safe before preceding to render care. You want to be able to give the best uninterrupted care to your patient without becoming a patient yourself. Jon: Doctor Holter. Mandeep: Doctor Singh.J - Doctor Holter: I will reach down and check the patient. “Sir, Sir, are you okay” – I am assessing for reactions from visual or verbal cues given by me. When the patient is unresponsive to verbal and visual cues, I will give a painful stimulus to the patient such as a nail bed pinch or sternal rub. Next, it is necessary to assess the pulse and breathing of the patient. Narrator: The reason we check if the patient is alert is to assess the neurologic activity. The lack of response to painful stimuli indicates there is no self-protect response. To assess the carotid pulse, you must palpate the carotid artery by placing the index and middle fingers near the upper neck between the sternomastoid and trachea roughly at the level of the cricoid cartilage. Assess breathing by checking the rise and fall of the chest. Lack of responsiveness, pulse, and breathing indicates that immediate Cardiopulmonary Resuscitation (CPR) needs to be initiated. J - Doctor Holter: Please call 911 and get an AED.M - Doctor Singh: I will call 911 and get an AED.J- Doctor Holter: I will place the person on their back and start single-person CPR until Doctor Singh comes back. Narrator: CPR is performed by placing the patient flat on their back on an even surface. Place the heel of your hand on the center of the person's chest (on the mid sternum) then place the palm of your other hand on top. Press down 5-6 cm (2-2.5 inches) at a rate of 100-120 beats per minute. Compressions should not be interrupted because they serve as an artificial way of contracting the heart and circulating the blood to maintain blood perfusion. For 1 or 2 person CPR on an adult: Give 5 cycles of 30 compressions to 2 breaths.For 1 person CPR on a child: Give 5 cycles of 30 compressions to 2 breaths.For 2 person CPR on a child: Give 5 cycles of 15 compressions to 2 breaths.M - Doctor Singh : Doctor Holter, continue the compressions and I will give rescue breaths and start to place the AED pads on the patient. Let me know if you are tired and we can switch to give high-quality CPR with adequate depth and rate. Narrator: The AED comes with a diagram made on the pads to instruct where to place the pads. Once an AED is positioned correctly on the patient's chest, let it detect if a shockable rhythm is present. Shockable rhythms include ventricular fibrillation and ventricular tachycardia. If there is not a shockable rhythm detected, then continue with CPR until a higher level of care is reached. If a shockable rhythm is detected, the AED will advise the users to step back and verbalize “clear” in order to ensure that everyone is clear of the patient. It will then administer a shock to the patient in the range of 120-200 Joules, based on the device manufacturer's recommendation.M - Doctor Singh: Doctor Holter, stay clear of the patient. The AED advises shocking the patient. I will press the button to administer the shock now.Narrator: After administration of the first shock, ACLS guidelines recommend continuing CPR for 2 minutes without checking for a pulse, as effective cardiac contractility lags behind the restoration of an organized electrical rhythm. After the next 2-minute cycle of CPR, the AED will reanalyze the patient's rhythm to determine if the rhythm is once again shockable. J - Doctor Holter: Doctor Singh , continue high-quality CPR while I initiate ACLS protocol. I will get an IV and start epinephrine. M- Doctor Singh: I will continue CPR in the meantime. Narrator: ACLS starts with again CPR, AED rhythm reading, and shock administration but with a higher level of care (ACLS). You must obtain IV or IO access. Epinephrine is administered every 3-5 minutes during the cycle in doses of 1 mg at a time. After each dose of epinephrine and CPR for 2 minutes the AED should reassess if the rhythm is shockable, and then continue CPR for another 2 minutes. At this time, it is recommended to use amiodarone or lidocaine. CPR will continue but at this time patient will likely be in the ambulance on the way to the hospital, and EMS will be managing the cycles. The cycles will continue until return of spontaneous circulation is obtained.J: Myocardial infarction is the most common cause of shock-refractory ventricular fibrillation, along with coronary artery disease. If CPR does not resume spontaneous circulation within 40-50 minutes, there is a decreased chance of recovery. Spontaneous circulation may be achieved in patients with refractory Vfib with coronary revascularization. Therefore, in addition to traditional CPR, venoarterial ECMO (extracorporeal membrane oxygenation) can be used as an adjunct and can result in much better systemic perfusion. Essentially, this is a technique in which blood is drained from the body and circulated outside through an oxygen and heat exchanger and is then reintroduced into the body. This technique can be used if preparing for coronary revascularization. M: Vfib is a great risk in the acute phase after MI, up to 72 hours after revascularization, due to the recent ischemia and reperfusion. After the first 72 hours and up to a month following, Vfib remains a risk due to the continued remodeling of the heart. This newly remodeled tissue can cause interruptions in the normal electrical signaling of the heart leading to dissociated contractions and subsequent lack of perfusion through the body, which can quickly lead to death within minutes if not recognized and managed immediately with CPR and defibrillation as described.J: Clinicians should be aware of their patients who would be more susceptible to serious events such as this and be on top of their training about management. This may not be a common occurrence in clinics, but it is a very serious event and requires a prompt and appropriate response. Conclusion: Now we conclude our episode number 98 “Apretude and code blue.” Dr. Yomi concisely explained how to use the new injectable medication for HIV Pre-Exposure Prophylaxis (PrEP). Then, Manpreet, Jon, and Sheinnera presented a case that can actually happen in clinic and anywhere. CPR is a life-saving skill that needs to be learned and practiced over and over so we are not taken by surprise. Remember that heart disease continues to be the number 1 killer in the United States. So, make sure you know where your AED is and be ready to use it when needed. Even without trying, every night you go to bed being a little wiser.This week we thank Hector Arreaza, Timiiye Yomi, Jennifer Thoene, Manpreet Singh, Jon-Ade Holter, and Sheinnera Gerongay.Thanks for listening to Rio Bravo qWeek Podcast. If you have any feedback, contact us by email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. Audio edition: Suraj Amrutia. See you next week!_____________________References:American Heart Association 2022 CPR cheat sheet. American Heart CPR Class, BLS, ACLS Ft. Myers all Lee County. (n.d.). Retrieved June 2, 2022, from https://www.cprblspros.com/cpr-cheat-sheet-2022. Algorithms. CPR & First Aid, Emergency Cardiovascular Care, American Heart Association, cpr.heart.org. Retrieved June 2, 2022, from https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines/algorithms. Bhar-Amato J, Davies W, Agarwal S. Ventricular Arrhythmia after Acute Myocardial Infarction: 'The Perfect Storm'. Arrhythm Electrophysiol Rev. 2017 Aug;6(3):134-139. doi: 10.15420/aer.2017.24.1. PMID: 29018522; PMCID: PMC5610731. Farkas, J. (2021, November 29). Post-mi complications. EMCrit Project. Retrieved June 2, 2022, from https://emcrit.org/ibcc/post-mi-complications/#ventricular_tachycardia.