Podcasts about Cytokine

In this episode, our host is joined by Dr. Peter Nigrovic, an expert in Macrophage Activation Syndrome (MAS). Dr. Nigrovic, delves into the complexities of MAS. The discussion covers the syndrome's history, diagnostic challenges, mechanisms of inflammation, and the latest treatment strategies, including cytokine blockade, JAK inhibitors, and chemotherapy options. Dr. Nigrovic also reflects on his unique career journey, offering valuable insights into combining clinical practice and research, while sharing his philosophy for a fulfilling life in medicine and science. This episode is a thorough exploration of MAS and provides practical advice for clinicians dealing with this complex syndrome. Macrophage Activation Syndrome 

This episode contains part 2 of our conversation with Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, about the Cytokine Crushers region of RheumMadness 2025.In this episode, we focus specifically on the TYK2 in SLE and Oral Anti-IL23 teams. Links to the Cytokine Crushers Scouting Reports:Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology FellowshipTYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology FellowshipLinks to theMednet.org Q&As about this region:What circumstances would drive you to consider using an oral IL-23 inhibitor over parenteral options for management of psoriasis/PsA?How will you utilize newly FDA approved anifrolumab for SLE in your practice?What is your experience with using oral deucravicitinib for conditions such as recalcitrant facial discoid lupus or recalcitrant lichen planus?To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

In this episode, we are joined by Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, to discuss the teams in the Cytokine Crushers region of RheumMadness 2025, the Innovation Invitational.This is part 1 of the conversation, where we go in depth about the long-term outcomes of anifrolumab in SLE study and give a primer about type 1/2 cytokines so you're ready to dig into the TYK2 in SLE and Oral Anti-IL23 studies.Join us again next week for part 2 of this discussion to learn more about this region.Links to the Cytokine Crushers Scouting Reports:Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology FellowshipTYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology FellowshipLinks to old scouting reports and other studies referenced in this podcast:TULIP 1/2 scouting report from RheumMadness 2021LLDAS scouting report from RheumMadness 2024Morand EF, Abreu G, Furie RA, Golder V, Tummala R. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus. Ann Rheum Dis. 2023 May;82(5):639-645. doi: 10.1136/ard-2022-222748. Epub 2023 Jan 23. Erratum in: Ann Rheum Dis. 2024 Apr 11;83(5):e12. doi: 10.1136/ard-2022-222748corr1. PMID: 36690388; PMCID: PMC10176410.Tanaka Y. Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice. RMD Open. 2023 Aug;9(3):e003270. doi: 10.1136/rmdopen-2023-003270. Erratum in: RMD Open. 2024 Apr 4;10(2):e003270corr1. doi: 10.1136/rmdopen-2023-003270corr1. PMID: 37597847; PMCID: PMC10441065.ORAL Surveillance scouting report from RheumMadness 2024To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive deep into the rapidly evolving world of CAR T cell therapy, a groundbreaking treatment for various hematologic malignancies. Joined by experts Dr. Surbhi Sidana from Stanford University and Dr. Jason Westin from MD Anderson Cancer Center, we explore the mechanism of action of CAR T cells, their side effects, and management strategies.   Episode Highlights: Understanding CAR T cell therapy and its application in hematologic malignancies and solid tumors. Mechanism of action: How CAR T cells are engineered to target cancer cells. Acute side effects: Cytokine release syndrome (CRS) and neurotoxicity, including clinical pearls for management. Chronic side effects: Monitoring for infections, cytopenias, and the risk of secondary malignancies. The importance of bridging therapy and managing tumor burden before CAR T treatment. Insights for community oncologists on patient management and communication with CAR T centers.   Join us for an informative discussion that emphasizes the importance of recognizing and managing the unique side effects of CAR T therapy to ensure the best outcomes for patients. Don't forget to check out our other episodes for more insights into recent advances in hematology and oncology!   Subscribe for more discussions on FDA approvals, treatment algorithms, and conference highlights. We are the Oncology Brothers!   Website: http://www.oncbrothers.com/ X/Twitter: https://twitter.com/oncbrothers Contact us at info@oncbrothers.com

Send us a textAs a result of the rapid adoption CAR-T therapy for certain lymphoid malignancies and multiple myeloma, of these treatments, CRS and ICANS will become more common in IM wards in the coming years. Take a listen to learn about how to treat this emerging condition. This episode was written by Dr. Veronica Ramirez (Internal Medicine Resident) and reviewed by Dr. Kelly Davison (Hematology) and Dr. Blair Schwartz (General Internist and Intensivist). Infographic by Neeloufar Grami (medical student).Support the show

Summary Dr. Mehdi Rashighi, MD, discusses groundbreaking research in dermatology focusing on autoimmune skin diseases. The conversation delves into multiomics research, the role of interferons in skin diseases, and the impact of UV exposure on conditions like cutaneous lupus and dermatomyositis. The episode highlights the importance of understanding cytokine signatures and the potential for new treatments targeting specific immune cells.   Takeaways The SFDerm 2024 meeting showcased significant advancements in dermatology. Multiomics research is crucial for understanding autoimmune skin diseases. Type one interferon plays a key role in cutaneous lupus and dermatomyositis. Cytokine signatures can help identify new treatment targets. Plasmacytoid dendritic cells are important in the pathogenesis of lupus. UV exposure can exacerbate skin diseases like lupus and dermatomyositis. Clinical trials are exploring monoclonal antibodies against interferons. Understanding photosensitivity is vital for managing lupus patients. Research is ongoing to better understand the immune response in skin diseases.   Chapters 00:00 - Introduction to the Future of Dermatology Podcast 00:56 - Exploring Multiomics in Dermatology Research 02:53 - Understanding Interferon Signatures in Skin Diseases 05:58 - Photosensitivity in Cutaneous Lupus and Dermatomyositis

In this week's episode, we'll learn about the role of a platelet-specific glycoprotein receptor in abdominal aortic aneurysm formation, the influence of TP53 mutations on outcomes for patients with 5q-deleted myelodysplastic syndrome, and a rational combination treatment intended to produce more durable responses in patients with refractory B-cell acute lymphoblastic leukemia who are treated with CAR T-cell therapy.Featured Articles:Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic targetInfluence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletionA phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations. Topics: 1. Introduction - Overview of Lyme disease and its causative agent, Borrelia burgdorferi. - Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB). 2. Understanding the Blood-Brain Barrier (BBB) - Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure. - Astrocytes: - Role in regulating blood flow through neurovascular coupling. - Interaction with neurons and release of vasoactive substances. - Contribution to BBB integrity by influencing tight junction formation. - Pericytes: - Contribution to BBB permeability and regulation through contractile capabilities. 3. Sponsor Break: Daily Nouri 4. Pathophysiology of Borrelia in the Brain - Invasion Mechanisms: - Borrelia's ability to adhere to and invade endothelial cells. - Role of surface proteins and induction of matrix metalloproteinases (MMPs). - Immune Evasion and CNS Invasion: - Antigenic variation to avoid immune detection. - Triggering of immune responses within the CNS, involving microglia and peripheral immune cells. - Cytokine production and its consequences on neuronal health. 5. Direct Impact on Brain Cells - Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis. - Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation. - Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions. 6. Sponsor Break: AX3 Life 7. Neurological Symptoms and Manifestations - Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS. - Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation. 8. Conclusion - Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach. - Recap of key points and reference to previous relevant episodes for further listening. Thank you to our episode sponsors: Check out Daily Nouri and use code CHLOE20 for 20% off your order. Check out ⁠AX3 Astaxanthin⁠ and use discount code ⁠CHLOE20⁠ for 20% off your first order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode of Talking Techniques, Ritwika Biswas, Field Application Scientist at Sino Biological US Inc. (PA, USA), discusses the use of cytokines in immunotherapy. Ritwika details the role of cytokines in the body, before going on to discuss how they can be used as therapeutics and to guide treatment decisions. Ritwika also shares how she thinks these proteins will be used in the future.Contents· Introduction: 00:00–01:35· The role of cytokines in the body: 01:35–02:52· Immune regulation and signaling: 02:52–05:40· Cytokine interactions and networks: 05:40–08:42· Modulating cytokine activity for therapeutic purposes: 08:42–12:35· The influence of cytokines on immunotherapy outcomes: 12:35–16:04· Using cytokines to predict treatment responses and guide immunotherapy decisions: 16:04–20:44· The importance of standardizing and validating cytokine diagnostic assays: 20:44–24:36· The future of cytokines in immunotherapy: 24:36–26:11 Hosted on Acast. See acast.com/privacy for more information.

Dr. Stacey Clardy talks with Dr. Georgios Mangioris to discuss his paper "Defining the CSF Cytokine and Chemokine Signature of Neurosarcoidosis." Show reference: https://index.mirasmart.com/AAN2024/PDFfiles/AAN2024-005404.html  This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. 

We explore how biotoxins impair cellular function and induce neuroinflammation, leading to systemic inflammation, chronic fatigue, and mitochondrial dysfunction. We also cover how biotoxins disrupt the HPA axis, affecting the body's stress response and adrenal function. Additionally, the conversation presents strategies to mitigate this energy deficiency and combat fatigue in the context of CIRS (lyme & mold). 1. Introduction to Biotoxin Illness - Definition and overview of biotoxins - Sources of exposure: Inhalation, contaminated water, ingestion, tick and spider bites - Genetic susceptibility and immune system's role 2. Mechanisms of Biotoxin Impact on Cellular Function - Biotoxins as fat-soluble molecules - Disruption of cell membranes and cell function - Ionophore-like structure of biotoxins 3. Specific Targets and Effects of Biotoxins - Predilection for fatty tissues and nervous system - Neurotoxin effects of Lyme disease - Impact on cardiovascular and gastrointestinal sites 4. Cellular and Systemic Consequences of Biotoxin Exposure - Impairment of mitochondrial function - Alterations in cellular signaling and ion concentrations - Decreased ATP production and its implications -- Veri -- 5. Neuroinflammation and Its Outcomes - Connection between cellular disruption and neuroinflammation - Effects on the adrenal glands - Role in chronic fatigue and energy depletion 6. Biotoxins and the HPA Axis - Overview of the HPA axis and its dysfunction due to biotoxins - Cytokine stimulation and hormonal cascades - Adrenal fatigue or insufficiency and altered cortisol production --Leela Quantum Tech-- 7. Strategies for Mitigating Cellular Energy Deficiency - Importance of a comprehensive treatment protocol - Mitochondrial support strategies - Adrenal gland support and circadian rhythm normalization 8. Mitochondrial Support Tools - Red light therapy - Dietary adjustments and supplements (e.g., Nicotinamide Riboside, CoQ10) - Importance of professional guidance in using mitochondrial support tools 9. Supporting the Adrenal Glands and Overall Energy - Adjustments to normalize circadian rhythm - Adrenal health Get a Veri CGM Here⁠ and use code VSM-THESYNTHESISOFWELLNESS ⁠Leela Quantum Tech Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode, we're talking about the relationship between viruses and depression. We'll cover how viral illnesses can negatively impact mood, how this process is completely natural, and how it can go awry. We'll hit on the role of inflammation, and how mood-regulating chemicals in the brain such as serotonin and dopamine can get disrupted. And of course, we'll cover some strategies to help restore our system after clearing a virus (i.e., rest, hydration, a nutrient-rich diet, and supportive supplements).   KEY MOMENTS: 00:00 Introduction to Joy Lab Podcast 00:38 Understanding Viruses and Mental Health 01:32 Personal Experience with Viral Illness 02:10 The Science Behind Viral Illness and Mood 04:39 The Role of the Immune System in Mood Regulation 07:44 Understanding Postviral Fatigue and Syndrome 10:40 Strategies for Mood Support After Clearing a Virus 11:57 The Role of Nutrition and Supplements in Recovery 15:11 Closing Thoughts and Quote 15:57 Disclaimer and Conclusion   Joy Lab and Natural Mental Health are community-supported. When you buy through the links below, we may earn a commission. That support helps keeps the Joy Lab podcast free for all!   Sources and Notes: Resilience Quiz and free Mini-Course: Based on decades of clinical experience, we've created a model of resilience that is both helpful and practical. True to our approach at Natural Mental Health, we start with strengths. You'll identify these strengths in your Resilience Type. Your Resilience Type highlights your unique strengths, what fuels your joy, what keeps you in balance, and the lifestyle practices that most nourish you. After you find your Resilience Type, sign up for your free mini-course to receive tailored lifestyle practices (e.g., foods to eat more of, ideal forms of exercise, supplements, and mindfulness activities) that can support your mood, resilience, and overall wellbeing. Resilient Community: Access lots of extra resilience-boosting resources (like our Sleeping Well Workshop) AND you'll join a group of inspiring folks who play an integral role in keeping this podcast going... which means powerful resources stay accessible to everyone.   Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Dantzer R. (2006). Cytokine, sickness behavior, and depression. Neurologic clinics, 24(3), 441–460. Access here. Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature reviews. Neuroscience, 9(1), 46–56. Access here. Supplements noted (to shop, sign up for your free Fullscript account here: https://us.fullscript.com/welcome/nmh/store-start): Immune Support Packets (comprehensive blend of many ingredients discussed in this episode) Vitamin C Ascorbic Acid capsules (Vitamin C) Omega 3's NeuroMood Pure Pack (Comprehensive daily packet providing vitamins, minerals, essential fatty acids, amino acids, and curcumin) OmegAvail Hi-Po (provides a potent 1600 mg of EPA/DHA per serving) Omega 3 DHA Vegan (this formulation originates from the microalga Schizochytrium sp., offering a high-quality alternative to animal-based food sources) Zinc UltraZin Zinc (enhanced absorption zinc) Mushroom and immune support blends Immunitone Plus (botanicals + mushroom extracts) M/R/S Mushroom Formula (combination of maitake, reishi and shiitake mushroom) Where to shop: Our partner store at Fullscript: This is where you can find high-quality supplements and wellness products. Except for our CBD Gummies, any product links mentioned in the show notes below will require an account. Sign up for your free Fullscript account here: https://us.fullscript.com/welcome/nmh/store-start Resilient Remedies: This is where you can find our line of trusted, high-quality CBD gummies: https://www.resilientremedies.com/ Subscribe to our Newsletter: Join us over at NaturalMentalHealth.com for exclusive emails, updates, and additional strategies. Check out our favorite resilience-boosting reads: https://bookshop.org/shop/NMHreads   Full transcript available at: https://www.naturalmentalhealth.com/podcasts/joy-lab-podcast/episodes/2148560676   Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.   

Teplizumab is a relatively new agent that helps delay the progression of type 1 diabetes. It slows the rate of beta-cell destruction in the pancreas. Teplizumab is associated with cytokine release syndrome which can result in flu-like symptoms of fever, aches, and headache. Cytokine release syndrome due to teplizumab can be reduced by using appropriate pretreatment medications. Those medications can include analgesics, antihistamines, and/or antiemetics. Teplizumab is associated with suppressing the immune system so it is ideal to get vaccinations completed before using this medication. I go over the specific recommendations in the podcast episode.

Immunotherapy Part II Special Guest: Matt McKenzie, PharmD, BCCCP @mgm485 04:40 – What is and when do we use immunotherapy? 09:00 – CAR-T cell therapy 15:20 – Standard ICU work-up 21:00 – Cytokine release syndrome (CRS) 35:00 – Immune effector cell-associated neurotoxicity syndrome (ICANS) 51:00 – Immune checkpoint inhibitors 64:30 – Summary and take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/02/immunotherapy-part-ii-references.pdf PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

References J Immunol. 2018 Feb 1; 200(3): 915–927 Fontana, GB. 1641 Violin Sonata 2. https://youtu.be/2kkpqJkYmms?si=w-JT4cbsn9hl7GSP --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Biochimica et Biophysica Acta (BBA) - Biomembranes 2015. Volume 1848, Issue 3. Pages 805-812. J Immunol. 2018 Feb 1; 200(3): 915–927. Am J Rhinol Allergy. 2015 Jan-Feb; 29(1): 35–40. Corelli,A. 1714. Concerto in D Major Op. 6 No. 4, https://youtu.be/3smZkpqXYHs?si=uwEdDkRv-bz-zJXW --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this monolog, Casey talks about a 2023 article from the National Institute of Biological Sciences (Beijun, China) about the role of cytokines and immune cells in sleep deprivation-induced mortality. Source: Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals - PubMed (nih.gov)

Welcome to our deep dive into Fibromyalgia (FM), a complex syndrome characterized by chronic pain and various other symptoms. In this episode, we'll explore effective strategies for managing FM. Before we delve into today's topic, let's talk about Zen, an adrenal support supplement. For those struggling with Fibromyalgia, balancing your adrenal health can be key to managing stress and inflammation. Zen is formulated to support your body's natural response to stress, aiding in your journey towards better health. Discover more about Zen and how it can complement your wellness regimen. https://www.mswnutrition.com/products/zen Show Notes: Dietary Changes for Fibromyalgia: Exploring the impact of low-carb and low-FODMAP diets on FM symptoms. Study on diet and Fibromyalgia: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551034/] The role of excitotoxins like MSG and aspartame in FM: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551285/] Inflammation and Fibromyalgia: Understanding the link between inflammation and FM. CRP and FM activity: [https://www.ima.org.il/MedicineIMAJ/viewarticle.aspx?year=2021&month=12&page=801] Cytokine production in FM patients: [https://www.aafp.org/pubs/afp/issues/2021/0501/p566.html] Vitamin B5 for Fibromyalgia: How pantothenic acid can potentially alleviate FM symptoms. Study on Vitamin B5 and pain severity in FM: [https://journals.sagepub.com/doi/10.1177/1099800420941109] Fasting as a Diet for Fibromyalgia: The potential benefits of intermittent fasting in managing chronic pain. Study on fasting and reduction in pro-inflammatory cytokines: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228511/] Community Support for Fibromyalgia: The importance of finding a supportive community for those with FM.       As we wrap up our discussion on Fibromyalgia, remember that managing this condition often requires a holistic approach. Alongside the strategies we've discussed, consider supporting your adrenal health with Zen. This carefully formulated supplement can be an integral part of yourdaily routine, providing the support your body needs to handle stress more effectively. Give Zen a try and feel the difference in your wellness journey. Learn more and purchase here: https://www.mswnutrition.com/products/zen Remember, each step you take towards understanding and managing Fibromyalgia brings you closer to a more comfortable and fulfilling life. Zen is here to support you on this path. Stay tuned for more insightful episodes and take charge of your health starting today!

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Publishing is broken (Solving for Science) Immune Dictionary (Nature) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Leaky gut symptoms go far beyond digestion. Let's look at the 8 tell-tale signs of leaky gut that you're likely overlooking.  Watch/Read Next… What is Leaky Gut? https://drruscio.com/what-is-leaky-gut/  The Elemental Diet: An Effective Therapy for Gut Relief https://drruscio.com/elemental-diet/  The 4 Most Effective Leaky Gut Treatments: https://www.youtube.com/watch?v=MW1ezm3d0JQ&t=1092s    Timestamps 00:00 Intro  00:49 What leaky gut is & how it's measured  03:08 The digestive symptoms  06:04 Body-wide (systemic) symptoms     Featured Studies  Association between increased intestinal permeability and disease: A systematic review: https://www.sciencedirect.com/science/article/abs/pii/S221295881730160X#:~:text=Results,and%2017%E2%80%9365%25%20respectively. Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial: https://pubmed.ncbi.nlm.nih.gov/35413837/ Specific Immunoglobulin E and G to Common Food Antigens and Increased Serum Zonulin in IBS Patients: A Single-Center Bulgarian Study: https://pubmed.ncbi.nlm.nih.gov/35466276/ Diet and intestinal bacterial overgrowth: Is there evidence?: https://pubmed.ncbi.nlm.nih.gov/35801041/ Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity: https://pubmed.ncbi.nlm.nih.gov/32693755/ Leaky Gut and the Ingredients That Help Treat It: A Review: https://pubmed.ncbi.nlm.nih.gov/36677677/#:~:text=Thus%2C%20leaky%20gut%20syndrome%20and,diabetes%20mellitus%2C%20and%20celiac%20disease. Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders: https://pubmed.ncbi.nlm.nih.gov/22013552/ Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D: https://pubmed.ncbi.nlm.nih.gov/31210949/ The Role of Leaky Gut in Functional Dyspepsia: https://pubmed.ncbi.nlm.nih.gov/35422683/ Duodenal Mucosal Barrier in Functional Dyspepsia: https://pubmed.ncbi.nlm.nih.gov/34607017/ Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis: https://pubmed.ncbi.nlm.nih.gov/33558650/ Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: https://pubmed.ncbi.nlm.nih.gov/27338587/ C-type lectin-like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease: https://pubmed.ncbi.nlm.nih.gov/31715011/ Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis: https://pubmed.ncbi.nlm.nih.gov/32332732/ Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis: https://pubmed.ncbi.nlm.nih.gov/29652034/ Dysbiosis in food allergy and implications for microbial therapeutics: https://pubmed.ncbi.nlm.nih.gov/33463542/ Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions: https://pubmed.ncbi.nlm.nih.gov/33670115/    Get the Latest Updates Facebook - https://www.facebook.com/DrRusciodc Instagram - https://www.instagram.com/drrusciodc/ Pinterest - https://www.pinterest.com/drmichaelrusciodc  DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

Today we discuss a research paper authored by a group of Western European researchers titled "A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema," which was published in the peer-reviewed journal International Journal of Molecular Sciences in March 2021.The primary aim of this study was to investigate whether there are molecular differences between lipedema fat and non-lipedema fat.The study yielded interesting findings, indicating the presence of a unique cytokine profile in lipedema fat.In conclusion, the authors highlight the distinct cytokine profile found in individuals with lipedema.This research holds significance for women affected by lipedema as it offers insights into the potential mechanisms behind symptom relief after surgery and the potential connections between systemic changes and specific immunological components.

On this episode Lara and Vyanka talk to Dr Darragh Duffy all about translational immunology and the Milieu Interieur project. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter. Hosted on Acast. See acast.com/privacy for more information.

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Dr. Gary Kaplan is a DO, clinical associate professor at Georgetown University School of Medicine, founder and medical director of the Kaplan Center for Integrative Medicine, and author of Why You Are Still Sick: How Infections Can Break Your Immune System and How You Can Recover. A pioneer and leader in the field of integrative medicine, Dr. Kaplan is one of only 19 physicians in the country to be board-certified in both Family Medicine and Pain Medicine. In this episode, Rachel and Dr. Kaplan discuss: Chronic fatigue syndrome and post-covid The root causes of covid-19 Environmental factors that can contribute to covid How long it takes for people to recover from covid-19 Cytokine pattern for post-covid and lyme syndrome Gentle things to do to maintain lower levels of toxins Reverse narcolepsy as an autoimmune disease Effective strategies to reduce inflammation Hidden infections that are often hidden in lab results Critical steps to healing post treatment Lyme syndrome Tips on stress reduction, exercise and meditation More from Victor: Website: www.KaplanClinic.com Facebook: KaplanCenterforIntegrativeMedicine Instagram: @kaplanclinic In November 8, 9, 10 - Dr Kaplan will chair an international conference on New Developments in Understanding Chronic Illness: The Role of the Immune Dysfunction and Infections registration here: http://medstarhealth.org/NDUCI2023 Product and Affiliation: Fullscript - get 15% off of professional-grade supplements: https://us.fullscript.com/welcome/rsmith1610125615 Baloo - https://balooliving.xayxet.net/4eyWyL Reach out to Rachel here: Book Your Free Consult With Rachel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://link.coachmatixmail.com/widget/appointment/rachelsmith/healthconsultation⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE 3 Day Nutrition & Detox Plan: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.naturalhealthrising.net/energy-reboot-plan⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Elimination Protocol Recipe Book: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.naturalhealthrising.net/recipe-book⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Natural Health Rising Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://naturalhealthrising.com/⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/rachel-smith11/support

References J Exp Med. 2017 Jul 3;214(7):1861-1876 Immunol Rev. 2014 Sep;261(1):62-83 Int J Mol Sci. 2022 Mar; 23(5): 2878. Immunity 2022. Volume 55, Issue 8. :1402-1413.e4 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

In this week's episode we'll discuss the findings from a study exploring the combination of concurrent pembrolizumab, adriamycin, vinblastine, and dacarbazine in newly diagnosed classical Hodgkin lymphoma, learn more about the effects of targeting the CD40/CD40-ligand axis in Waldenström Macroglobulinemia, and review the findings from a study aimed at improving the bone marrow homing of CAR-cytokine induced killer cells in AML.

Join Drs Amelia Langston and Jean Koff as they discuss the monitoring and management of complications before, during, and after CAR T therapy. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987066). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Cancer Immunotherapy With Chimeric Antigen Receptor (CAR) T Cells https://emedicine.medscape.com/article/2500108-overview Cytokine Release Syndrome https://emedicine.medscape.com/article/2500111-overview Immune Effector Cell Associated Neurotoxicity Syndrome in Chimeric Antigen Receptor-T Cell Therapy https://pubmed.ncbi.nlm.nih.gov/36081506/ On-target and Off-target-based Toxicologic Effects https://pubmed.ncbi.nlm.nih.gov/23085982/ Cytokine https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cytokine Tocilizumab (Rx) https://reference.medscape.com/drug/actemra-tocilizumab-999419 CARTOX 10 Point Neurological Assessment https://reference.medscape.com/viewarticle/886616_5 Levetiracetam https://www.ncbi.nlm.nih.gov/books/NBK499890/ Cytopenia After CAR-T Cell Therapy-A Brief Review of a Complex Problem https://pubmed.ncbi.nlm.nih.gov/35326654/ Immune Effector Cell-associated Hemophagocytic Lymphohistiocytosis-like Syndrome https://pubmed.ncbi.nlm.nih.gov/36906275/ Management of Hypogammaglobulinaemia and B-cell Aplasia https://www.ncbi.nlm.nih.gov/books/NBK584138/ Rituximab (Rx) https://reference.medscape.com/drug/rituxan-truxima-rituximab-342243 Bispecific Targeting of CD20 and CD19 Increases Polyfunctionality of Chimeric Antigen Receptor T-cell Products in B-cell Malignancies https://pubmed.ncbi.nlm.nih.gov/35597752/ Mantle Cell Lymphoma https://www.ncbi.nlm.nih.gov/books/NBK536985/ Chimeric Antigen Receptor (CAR) T-cell Treatment for Mantle Cell Lymphoma (MCL) https://pubmed.ncbi.nlm.nih.gov/35237395/ Apheresis https://www.cancer.gov/publications/dictionaries/cancer-terms/def/apheresis

Welcome to the emDOCs.net podcast! Join us as we review our high-yield posts from our website emDOCs.net. Today on the emDOCs cast, Brit Long, MD (@long_brit) covers Part 1 in a series on complications of CAR T-cell therapy, specifically cytokine release syndrome (CRS). To continue to make this a worthwhile podcast for you to listen to, we appreciate any feedback and comments you may have for us. Please let us know!Subscribe to the podcast on one of the many platforms below:Apple iTunesSpotifyGoogle Play

In episode 49 of Derms and Conditions, James Q. Del Rosso, DO and Mark Lebwohl, MD discussed the pathophysiology of atopic dermatitis and the role of cytokines in its management. Drs. Lebwohl and Del Rosso discussed how specific cytokines can be targeted for a safer treatment of atopic dermatitis. They emphasized that the targeted therapies for atopic dermatitis do not have any boxed warnings and the treatment of cytokines, specifically interleukin-4 (IL-4) and IL-13, can significantly improve itching and dermatitis. Dr. Lebwohl discussed the inhibiting of IL-13 to make atopic dermatitis better and that blocking IL-4 and IL-13 was highly effective for treating atopic dermatitis. In terms of utilizing less targeted therapies, Dr. Lebwohl stated that all the drugs they use work by knocking down IL-13 but with varying side effects. The use of old drugs such as methotrexate and cyclosporine has several side effects, and doctors need to be cautious about their usage.

Joe Horn and Daniel Belt present a two-part special program on what is called “Long Covid” and what can be done to avoid and/or cleanse the body of this malady. The World Health Organization defines long Covid as symptoms that start (usually) within three months of having Covid, last for at least two months but can last for years, and can't be explained by another condition. Symptoms can fluctuate or relapse over time. The most commonly reported long Covid symptoms are: fatigue, difficulty concentrating, breathlessness or shortness of breath, and muscle aches, but over 200 symptoms have been identified related to this condition. What are Spike Proteins, Cytokine Storms, and Micro-Clotting, and how are they related to long-covid? Can anything be done to find relief and healing? Watch this very timely presentation to learn the truth!

References Antioxidants (Basel). 2023 Feb; 12(2): 274 J Lipid Res. 2016 May; 57(5): 868–881. J Biol Chem. 2007 Jan 12;282(2):1384-96. J. Am. Chem. Soc. 2014, 136, 36, 12624–12630 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

References Guerra's immunology lectures Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Genes (Basel). 2021 Aug; 12(8): 1118 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

References Naunyn Schmiedebergs Arch Pharmacol . 2014 Apr;387(4):329-39. J Biol Chem. 2013 Mar 8; 288(10): 7137–7146 J Anim Sci. 1998 Jan;76(1):160-72 Journal of Bone Oncology 2017. Volume 9: 34-40 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

References Nature. 2019 Jul; 571(7765): 403–407 Dr Guerra's lectures --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

In this week's episode we will first review a new clinical trial evidence that for patients with sickle cell anemia in resource limited settings, both low and moderate dose hydroxyurea are effective for secondary stroke prevention. Next, a research article showing how secreted mutant calreticulin functions as a “rogue cytokine” in myeloproliferative neoplasms, acting in a paracrine manner to promote growth of nearby tumor cells. Finally, we'll review new research on the pathobiology of adult and pediatric Burkitt lymphoma. With the help of whole-genome sequencing, investigators unraveled distinct subgroups, which may provide a new framework for epidemiology, diagnosis, and treatment of these lymphomas.

references J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161 Connect Tissue Res. 2017 Jan; 58(1): 49–63. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. David Brady and Tom Fabian, PhD discuss Cytokine Testing with Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]    Podcast Highlights       […]

Cytokines control nearly all aspects of the immune system. As drugs, though, they have limited potential because of inherent drawbacks. Simcha Therapeutics is engineering versions of cytokines to activate various immune cells in the fight against cancer. Simcha's most advanced program, ST-067, is the first in a new class of interleukin-18 based immunotherapies designed to overcome a key defense mechanism that the tumor microenvironment produces to prevent Interleukin-18 from doing its work. We spoke to Sanuj Ravindran, CEO of Simcha Therapeutics, about the company's engineered cytokines, how they work, and why they may represent a powerful addition to the immunotherapy arsenal.

Regenerative plasma exchange is showing some remarkable results. What can it offer for patients to prevent or treat Alzheimer's disease and even overall longevity.David Haase MD is a doctor, teacher, author and innovator. In his practice, he strives to be a super generalist looking at the human body as a whole and applying curiosity to identify and treat the root cause of a patient's disease. After receiving his medical degree from Vanderbilt University, he trained at the Mayo Clinic and is now double boarded in family and integrative holistic medicine. He serves as lead faculty for the Institute for Functional Medicine. As founder and medical director of the Maxwell clinic, he works to help his patients uncover the root cause of their illness and achieve better health.LINKS:David Haase MD FacebookLinkedInMaxwell ClinicFunctional Medicine Coaching OrgTIMESTAMPS:00:20 - Introduction to the speaker02:38 - Modern medicine06:03 - Alzheimer's disease10:37 - Metabolic disease12:48 - Cognitive impairment15:15 - Neurocognitive testing17:39 - Hypertension18:47 - Apheresis / Therapeutic plasma exchange19:47 - Plasma dilution process28:16 - Glutathione30:37 - Cytokine reservoir37:14 - Maxwell Clinic----------#alzheimer #plasmaexchange #disease #albumin #cognitivedecline #brain #neurodegeneration#robertlufkinmd #drlufkin #robertlufkin #healthlongevitysecrets*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter: https://twitter.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMD*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://robertlufkinmd.com/contact NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.Support the show

Taking a minor break from ruffling the f*cking cages and feathers of what we call modern society these days and I wanted to talk about something a bit more conventional but important nevertheless and that is sleep. I have a multitude of studies for you to do your own research as I want to present this topic as clear cut as possible.   Time Stamps:   (0:28) Are You Enjoying the Podcast? (2:30) Going On a Journey With Sleep (6:40) Adverse Effects From Poor Sleep (16:30) Stress and the Blood-Brain Barrier (18:50) Naps ---------------------------- Resources: [i] Pilcher JJ, Walters AS. How sleep deprivation affects psychological variables related to college students' cognitive performance. J Am Coll Health. 1997 Nov;46(3):121-6. View Abstract [ii] Walker MP, et al. Practice with sleep makes perfect: sleep-dependent motor skill learning. Neuron. 2002 Jul 3;35(1):205-11. View Abstract [iii] Rosen IM, et al. Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among interns. Acad Med. 2006 Jan;81(1):82-5. View Abstract [iv] Cohen S, et al. Sleep habits and susceptibility to the common cold. Arch Intern Med. 2009 Jan 12;169(1):62-7. View Full Paper [v] Patel SR, et al. Association between reduced sleep and weight gain in women. Am J Epidemiol. 2006 Nov 15;164(10):947-54. View Full Paper [vi] Donga E, et al. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. 2010 Jun;95(6):2963-8. View Abstract [vii] Williamson AM, Feyer AM. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occup Environ Med. 2000 Oct;57(10):649-55. View Full Paper [viii] Kim TW, Jeong JH, Hong SC. The impact of sleep and circadian disturbance on hormones and metabolism. Int J Endocrinol. 2015;2015:591729. View Full Paper [ix] Vgontzas AN, et al. IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12(3):131-40. View Abstract [x] Meier-Ewert HK, et al. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin Chem. 2001 Mar;47(3):426-30. View Full Paper [xi] Meier-Ewert HK, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. View Abstract [xii] van Leeuwen WM, et al. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS One. 2009;4(2):e4589. View Full Paper [xiii] Chennaoui M, et al. Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men. Cytokine. 2011 Nov;56(2):318-24. View Abstract [xiv] Vgontzas AN, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002 Jul;51(7):887-92. View Abstract [xv] He J, et al. Sleep restriction impairs blood-brain barrier function. J Neurosci. 2014 Oct 29;34(44):14697-706. View Full Paper [xvi] Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24;57(2):178-201. View Abstract [xvii] Hurtado-Alvarado G, et al. Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link. J Immunol Res. 2016;2016:4576012. View Full Paper [xviii] Esposito P, et al. Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. J Pharmacol Exp Ther. 2002 Dec;303(3):1061-6. View Full Paper [xix] Steiger A. Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med Rev. 2002 Apr;6(2):125-38. View Abstract [xx] Vgontzas AN, et al. Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E253-61. View Full Paper ---------------------------- Follow Me on Instagram! @tayloredwellbeing ---------------------------- Click Here to Apply to Work with Me or visit taylorsappington.com/application

References Dr Guerra's membrane immune synapse lectures Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1 Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion. J Biol Chem. 2018 Sep 7;293(36):14022-14039. doi: 10.1074/jbc.RA118.003097. Epub 2018 Jul 17. PMID: 30018141; --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Cytokine release syndrome (CRS) — sometimes called cytokine storm or cytokine-associated toxicity — is a condition that develops when your immune system responds too aggressively to infection.  In this episode, Dr. Amy discusses what can cause a Cytokine Storm, and ways to prevent and treat CRS. 

On this weeks episode, I give you my final thoughts on COVID-19.Topics Discussed:3:11 - Asymptomatic spread and why viruses don't want to kill their hosts9:18 - PCR testing fiasco10:59 - Reports of Covid in the water supply prior to 2020 and people with antibodies to Covid prior to 201912:16 - Social media censorship that I experienced from the beginning15:18 - Why diabetics, males, and smokers were getting hit that hardest from Covid20:51 - I explain ACE receptors & Cytokine storms27:13 - How viruses act inside the obese body36:20 - What we did to our senior citizensDownload my FREE BOOK and get on my email list. Follow me on my Substack BlogSponsored by: The Dr. Tyna StoreGet 10% OFF my Main Store and my CBD Store here.Further Listening:Muscle is MedicineToxic Legacy: Glyphosate, Deuterium and the COVID vaccine Get full access to Dr. Tyna Show Podcast & Censorship-Free Blog at drtyna.substack.com/subscribe

In this episode, we talk about a paper published in 2021 titled A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema. Mentioned in this episode: Lipedema & Lymphedema Heart to Heart: A Collaborative 3-Day Learning Event Join us for three days full of immersive learning and discover cutting-edge holistic strategies that would help to drastically improve your health... and your quality of life. https://lipedema.captivate.fm/heart2heart (Join our Event!)

In this episode, host Dr. Amber Luong speaks with Dr. Naweed Chowdhury. They will discuss article: Association of cytokine profile with prior treatment failure and revision surgery in chronic rhinosinusitis. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.

Swiss-Italian biopharma company Philogen was co-founded in 1996 by three brothers, all of them PhDs. This unique family affair has fueled the development of an incredibly deep and advanced pipeline of no fewer than ten  therapeutic products, most of them in oncology, contributing to 16 active clinical trials, three of them at Phase 3. On this episode of the Business of Biotech, co-founder, CEO, and CSO Prof. Dario Neri shares the incredible story of the company's progress and explains Philogen's approach to  delivering bioactive agents to the site of disease using antibodies or small organic ligands, thus increasing  therapeutic activity and helping spare normal tissues. 

Emergencies happen in hematology and oncology. This is a fact. But how do we manage these emergencies? Look no further. In this episode, we talk all about our fourth hematologic emergency: thrombotic thrombocytopenic purpura (TTP). Thrombotic thrombocytopenic purpura (TTP):- Be sure to check out episode 009 on thrombocytopenia for a general approach and differential!- New anemia and thrombocytopenia should raise concerns for TTP! Workup: - Peripheral smear - concern for schistocytes. Look at this first! Example of these cells from ASH image bank here- ADAMTS13 level - always draw ASAP before any intervention- Repeat CBC- Reticulocyte count - will have elevated retic count- Citrated platelet count - CMP- PT, PTT, INR- Fibrinogen- Haptoglobin - LDH- Viral serologies Clinical manifestations: - Fever, Anemia, Thrombocytopenia, Renal (AKI), Altered Mental Status- If you see this - the patient is in bad shapeMechanism:- Tiny blood clots form in the body, causing platelet shearing- Loss of ADAMTS13 - This protein normally is responsible for chopping up von Willebrand's factor (vWF)- In the absence of ADAMTS13, vWF multimers are extra long, therefore interacting with platelets/collagen more and causing activation of platelets and clotting system- This causes red blood cell shearing due to small vessel microthrombi (brain, kidneys, heart)- Cytokine release causes fevers Management:- Do not reflexively transfuse platelets; can make situation worse - PLASMIC Score: helps to stratify likelihood of TTP; MDCalc link (https://www.mdcalc.com/plasmic-score-ttp)Treatment: - Plasma exchange: replacing ADATMS13-deficient plasma with ADAMTS13-rich plasma- This is different than plasmapheresis, where we replace plasma with albumin- Steroids: 1mg/kg prednisone daily to stop auto-antibody (against ADAMTS13) production- Confirm with ADAMTS13 levels; if

Since you're here you might as well earn CEs. Find out how to earn CEs for this course here. Read about Polyvagal Theory and Cytokine's role in inflammation here.  Read my blogpost about polyvagal theory and the paradox is presents