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New Orleans Saints vs. Seattle Seahawks NFL Pick Prediction 9/21/2025 by Tony T. Saints at Seahawks Injuries New Orleans left guard and right tackle are questionable. On defense a linebacker is outs. Seattle receiver Smith Njigba is questionable with an illness. On defense a safety and nickel back are out. Seattle has a clear injury advantage based on the Chao ratings. Recent Box Score Key Stats Saints at Seahawks 4PM ET—New Orleans is 0-2 with their 26-21 home defeat to San Francisco. The Saints rushed for 121 yards for four yards a carry and were inefficient in the passing game with 6.1 yards per pass attempt. They limited the 49ers to 77 yards rushing but 267 yards passing for 6.8 yards per pass attempt. Spencer Rattler hit 25 of 34 for 207 yards with three touchdowns. Seattle is 1-1 after their 31-17 road win at Pittsburgh. The Seahawks gained rushed for 117 yards for 4 yards a carry end effective in the passing game. They held the Steelers to 72 yards rushing with 5.5 yards per pass attempt. Sam Darnold hit 22 of 33 for 295 yards with two touchdowns and two interceptions.