Podcasts about disease conditions

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.03.324822v1?rss=1 Authors: Bose, D., Islam, R., Saha, S., Chakrabarti, A. Abstract: Spectrin, the major component of the erythrocyte membrane skeleton is a key player in red cell biology. It has a significant role in signalling pathways and as such knowledge of spectrin interactors becomes crucial. Here we report the cytosolic interactome of human erythroid spectrin (ProteomeXchange id: PXD021525). This is to the best of our knowledge the first report of the interactome of human erythroid spectrin. We have further investigated the spectrin interactome under HbE disease conditions. Our findings indicate that there is no difference in the identity of the proteins interacting with spectrin between normal and disease conditions. However relative abundance of the interacting partners is seen to change. Very interestingly the interacting chaperone proteins, heme-containing proteins and redox active proteins are seen to be up-regulated in HbE disease state. This is consistent with our previous observation that presence of oxidation prone hemoglobin variants leads to an increase of redox regulators and chaperones in the red cell proteome. Spectrin can also interact with horse radish peroxidase and oxidatively crosslink hemoglobin, which has possible implications in oxidative stress management. Since a large fraction of spectrin interacting proteins are chaperones and redox active proteins, it is possible that spectrin may have a broader role in redox regulation, especially in cases where there are unstable hemoglobin variants present. Copy rights belong to original authors. Visit the link for more info

Learn the secret to living a longer, healthier, and more fulfilled life.Most of us want to lose weight and live a healthier and longer life.Order Carnivora: Nature’s Nutritional Powerhouse -sponsorThe key to making that happen requires being able to provide our body the best chance at cell protection and rejuvenation. Dr. Valter Longo, author of The Longevity Diet, joins Dr. Friedman to share his scientifically engineered fasting mimicking diet, a proven approach to losing weight, extending your lifespan, and building your resistance to diabetes, cardiovascular disease, Alzheimer's, and cancer. Listen in to learn the secret to living a longer, healthier, and more fulfilled life.

Learn the secret to living a longer, healthier, and more fulfilled life.Most of us want to lose weight and live a healthier and longer life.Order Carnivora: Nature’s Nutritional Powerhouse -sponsorThe key to making that happen requires being able to provide our body the best chance at cell protection and rejuvenation. Dr. Valter Longo, author of The Longevity Diet, joins Dr. Friedman to share his scientifically engineered fasting mimicking diet, a proven approach to losing weight, extending your lifespan, and building your resistance to diabetes, cardiovascular disease, Alzheimer's, and cancer. Listen in to learn the secret to living a longer, healthier, and more fulfilled life.

Nate Malloy shares the benefits of taking a health and wellness approach in medicine to help fight disease.

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The Vector-borne Disease Laboratory at Maine Medical Center Research Institute is dedicated to the control of emerging tick-and mosquito-borne diseases. We seek to understand the environmental interactions of vectors, hosts, habitats, and climate; monitor the geography of risk; and increase public awareness of the threat of tick-and mosquito-borne diseases.Chuck Lubelczyk, Vector Ecologist, is here to help understand the environmental interactions of vectors, hosts, habitats, and climate; monitor the geography of risk; and increase public awareness of the threat of tick-and mosquito-borne diseases.

The Vector-borne Disease Laboratory at Maine Medical Center Research Institute is dedicated to the control of emerging tick-and mosquito-borne diseases. We seek to understand the environmental interactions of vectors, hosts, habitats, and climate; monitor the geography of risk; and increase public awareness of the threat of tick-and mosquito-borne diseases.Chuck Lubelczyk, Vector Ecologist, is here to help understand the environmental interactions of vectors, hosts, habitats, and climate; monitor the geography of risk; and increase public awareness of the threat of tick-and mosquito-borne diseases.

The Vector-borne Disease Laboratory at Maine Medical Center Research Institute is dedicated to the control of emerging tick-and mosquito-borne diseases. Chuck Lubelczyk, Vector Ecologist, is here to help understand the environmental interactions of vectors, hosts, habitats, and climate; monitor the geography of risk; and increase public awareness of the threat of tick-and mosquito-borne diseases.

Necrotizing fasciitis is a bacterial infection that can spread rapidly throughout your body and destroy its soft tissue.Necrotizing fasciitis, also known as the "flesh-eating disease," is a bacterial infection that can spread rapidly throughout your body and destroy its soft tissue.According to the National Necrotizing Fasciitis Foundation, the bacterium that causes necrotizing fasciitis is within the group A Strep bacteria, the same bacteria that can cause strep throat.With just a cut, burn or bump to your skin, bacteria enters your body and can cause this flesh-eating disease. Depending on how moderate the case, you can be treated with heavy antibiotics.However, delaying care can cause the disease to worsen, allowing the toxins from the disease to destroy the tissue it infects. As a result, your tissues start to die.Even though your chances of getting this disease are very slim, it's important to recognize the symptoms and what could be posing serious health threats to you or a loved one.NeutroPhase is the newest treatment for necrotizing fasciitis. It contains Hypochlorous acid, a natural substance, which, when produced in the body's immune system, serves as a first defense against microbial invaders.How does this treatment differ from other alternative treatments?John Crew, MD, joins Melanie Cole, MS, to discuss what necrotizing fasciitis is, the symptoms of the disease and the newest treatment options available.

Necrotizing fasciitis is a bacterial infection that can spread rapidly throughout your body and destroy its soft tissue.Necrotizing fasciitis, also known as the "flesh-eating disease," is a bacterial infection that can spread rapidly throughout your body and destroy its soft tissue.According to the National Necrotizing Fasciitis Foundation, the bacterium that causes necrotizing fasciitis is within the group A Strep bacteria, the same bacteria that can cause strep throat.With just a cut, burn or bump to your skin, bacteria enters your body and can cause this flesh-eating disease. Depending on how moderate the case, you can be treated with heavy antibiotics.However, delaying care can cause the disease to worsen, allowing the toxins from the disease to destroy the tissue it infects. As a result, your tissues start to die.Even though your chances of getting this disease are very slim, it's important to recognize the symptoms and what could be posing serious health threats to you or a loved one.NeutroPhase is the newest treatment for necrotizing fasciitis. It contains Hypochlorous acid, a natural substance, which, when produced in the body's immune system, serves as a first defense against microbial invaders.How does this treatment differ from other alternative treatments?John Crew, MD, joins Melanie Cole, MS, to discuss what necrotizing fasciitis is, the symptoms of the disease and the newest treatment options available.