Podcasts about Normal

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    Latest podcast episodes about Normal

    Build Your Network
    INTERVIEW | Make Money by Building Wealth Through Real Estate, Cash Flow, and Alternative Investments with Buck Joffrey

    Build Your Network

    Play Episode Listen Later Jun 17, 2026 26:22


    Buck Joffrey is a former surgeon turned entrepreneur, real estate investor, and financial educator who has participated in more than $2 billion worth of real estate transactions. After training at UCSF and building a successful cosmetic surgery practice from scratch, Buck shifted his focus to real estate syndications, alternative investments, and financial education. As the host of the Wealth Formula Podcast and author of The 7 Secrets of Eternal Wealth, he helps high-income professionals take greater control of their finances and build long-term wealth through cash-flowing assets. On this episode we talk about: How Buck built a successful cosmetic surgery practice using aggressive marketing and entrepreneurship The difference between personal money and business money when scaling a company Why Buck transitioned from medicine into real estate investing and syndications How his podcast became the foundation for building an investor community and raising capital Why multifamily real estate may present a compelling opportunity in today's market Top 3 Takeaways Successful entrepreneurs understand that business spending should be evaluated based on return on investment, not personal spending habits. Building wealth often requires creating multiple streams of income and investing in cash-flow-producing assets rather than relying on a single source of income. Some of the best investment opportunities emerge when an asset class is out of favor—smart investors look for value rather than chasing what's currently popular. Notable Quotes "The more I'd spend, the more I'd make. So why not?" "Normal people money is not the same as business money." "When people go to the store, they look for what's on sale. But when they invest, for some reason the things on sale don't look attractive." Connect with Buck Joffrey: LinkedIn: https://www.linkedin.com/in/buck-joffrey-md/ Instagram: https://www.instagram.com/buck.joffrey/ Other: https://www.wealthformula.com/ A Word from Our Sponsors: Today's episode is brought to you by our incredible sponsors. Their support helps us continue bringing you conversations with world-class entrepreneurs, investors, and thought leaders. Please support the companies that support the show by checking out their products and services in the links below. - Are you ready to start your own creatorjourney and make it big? Visitwww.fanvue.com today and launch yourcareer! - To learn more about Mode Mobile and its investor community, go to https://invest.modemobile.com/travismakesmoney -Travis Makes Money is made possible by High Level – the All-In-One Sales & Marketing Platform built for agencies, by an agency.Capture leads, nurture them, and close more deals—all from one powerful platform.Get an extended free trial at gohighlevel.com/travis Learn more about your ad choices. Visit megaphone.fm/adchoices

    The Freedom Friends
    Normal Then, Crazy Now (A Freedom Friends Master Debate)

    The Freedom Friends

    Play Episode Listen Later Jun 17, 2026 37:10


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    The Women's Vibrancy Code
    234. When Your Labs Say You're Fine But You Know You're Not

    The Women's Vibrancy Code

    Play Episode Listen Later Jun 17, 2026 14:59


    Normal lab results don't always mean optimal health. In this episode of The Women's Vibrancy Code, Maraya Brown reveals why symptoms like fatigue, brain fog, hormone imbalance, anxiety, weight gain, and low libido can be overlooked, and how understanding the full picture can help you finally get the answers your body has been asking for. The Women's Vibrancy Accelerator Trifecta: Your 90-Day Health Reset Ready to take your health to the next level? The Women's Vibrancy Accelerator Trifecta offers deep, personalized support to help you regain control of your energy, hormones, and well-being. This program includes: Three one-on-one calls with Maraya Dutch Plus Test and full assessment Bi-weekly live Q&A sessions Self-paced health portal covering energy, hormones, libido, and confidence   Podcast listeners get an exclusive discount. Use code PODCAST. Learn more and enroll now: https://marayabrown.com/trifecta/ _______________________ Free Wellness Resources Access free tools like the Menstrual Tracker, Adaptogen Elixir Recipes, Two-Week Soul Cleanse, Food Facial, and more. Download now: https://marayabrown.com/resources/ _______________________ Subscribe to The Women's Vibrancy Code Podcast Listen on Apple Podcasts, YouTube, and Spotify. _______________________ Connect with the Show Find us on Facebook,  Linkedin | Website | Tiktok | Facebook Group _______________________ Apply for a Call with Maraya Brown Start your journey with personalized support. Apply here: https://marayabrown.com/call  _______________________ About Maraya Brown Maraya is a Yale and Functional Medicine-trained Women's Health and Wellness Expert (CNM, MSN). She helps women feel energized, confident, and connected to themselves and their lives. With over 25 years of experience, she specializes in energy, hormones, libido, confidence, and deep transformation. _______________________ Disclaimer The content of this podcast is for informational, educational, and entertainment purposes only and does not constitute medical or professional advice. Listeners should consult with a qualified professional before making any health decisions.   This Podcast Is Produced, Engineered & Edited By: Simplified Impact 

    The Mountain Top For Men (formerly The Chick Whisperer):
    All I Want Is A Normal Woman. Is That So Hard?

    The Mountain Top For Men (formerly The Chick Whisperer):

    Play Episode Listen Later Jun 16, 2026 6:28


    ===SNIPPETS FROM THE SUMMIT=== It's easy for us as men to say we'd really just like a normal, pretty average woman. After all, if you're who I call "Gen-Eric" you're wearing normal clothes, driving a normal car, working a normal job and living a normal life. So why wouldn't a woman like "Gen-Erica" who seems to match up well with you not want you? Well, that's not how it works, unfortunately. While it's definitely not about "average" women requiring some Chad to spoil them rotten, there is a certain part of your masculine nature that needs to be activated in order to get the result you want. And guess what? You're likely to transform that "normal, average woman" into her best self in the process. Take the Reality Check Inventory quiz for FREE at: https://mountaintoppodcast.com/realitycheck === HELP US SEND THE MESSAGE TO GREAT MEN EVERYWHERE === Snippets From The Summit are all about completely original ideas for success with women that also happen to be extremely effective...and actionable. It's all built on the "Big Four": Confidence, Masculinity, Liking Women, and Good Character. Better men get better women. If you love what you hear, please rate the show on the service you subscribed to it on (takes one second) and leave a review.

    Thyroid Answers Podcast
    Episode 235: Your Thyroid Labs Are "Normal"… But Are They Appropriate?

    Thyroid Answers Podcast

    Play Episode Listen Later Jun 16, 2026 71:46


    If you've ever been told your thyroid labs are "normal" but you still feel exhausted, cold, constipated, anxious, inflamed, or unable to lose weight, this episode is for you. In this episode of The Thyroid Answers Podcast, Dr. Eric Balcavage explores one of the most misunderstood concepts in thyroid care: the difference between a thyroid lab value being normal and being appropriate for your physiology. He explains why thyroid lab markers such as TSH, Free T4, Free T3, Reverse T3, and thyroid antibodies are often interpreted too simplistically and why normal lab values do not always mean healthy thyroid function. Dr. Balcavage breaks down how stress physiology, inflammation, immune activity, gut dysfunction, sleep disruption, nutrient deficiencies, and overall physiologic state can influence thyroid hormone production and T4-to-T3 conversion. He also explains why many thyroid patterns may actually represent adaptive responses rather than broken physiology. You'll learn how to interpret thyroid labs within the context of symptoms, health history, inflammatory markers, and overall physiologic state, and why focusing solely on optimizing lab values often fails to restore true health and well-being. Whether you're struggling with persistent hypothyroid symptoms despite normal labs or you're trying to better understand your thyroid physiology, this episode provides a deeper framework for understanding what your thyroid labs may really be telling you. In This Episode, You'll Learn: Why normal labs don't always equal healthy thyroid function How to determine if your thyroid labs are actually appropriate for your physiology The role stress, inflammation, and lifestyle factors play in thyroid hormone regulation Why low T3 and poor conversion may be adaptive responses Why thyroid medication doesn't always resolve symptoms What to focus on beyond lab values to support better thyroid health Resources Mentioned:

    normal labs thyroid root cause t3 t4 tsh reverse t3 free t3 free t4 balcavage thyroid debacle
    Lift Free And Diet Hard with Andrew Coates
    #478 Steve Kamb - How To Try Again

    Lift Free And Diet Hard with Andrew Coates

    Play Episode Listen Later Jun 16, 2026 55:22


    Steve Kamb joins me to talk about the ideas from his new book, How to Try Again: An Approachable Guide to Navigating Chaos and Making Change.Steve shares wisdom about:Which is harder: starting, or starting againThe "Back to Normal" fallacyThe importance of a bias toward actionDo people wait for optimal timing?Do people believe it will go smoothly this time?Do people fail to anticipate obvious and predictable obstacles?Do people fail to allow for unforeseen obstacles?When do we need to try again and when do we need to try something different?How much do people try to control the wrong things?How much of success comes down to one's attitude toward struggle and failure?If you're someone who's been trying and faltering, this is for you—whether in fitness and health, career, or life.Instagram: @stevekambCHAPTERS01:15 Starting vs Starting Over03:01 The Back to Normal Fallacy06:18 Why Treading Water Still Counts08:34 Letting Go of the Perfect Future13:05 The Too Many Options Trap17:25 Procrastination and the Five Whys19:53 Identity and Imposter Syndrome22:53 Failure as Feedback24:14 Keep Doing the Thing28:17 New Year's Goals and Self-Efficacy32:37 Pause, Accept, Change, Try Again37:32 Control What You Can Control41:36 The "Yes And" Philosophy of Life47:41 Struggle, Capacity, and Resilience51:04 Updating Your Fitness Identity53:37 Book Launch and Where To Find SteveSUPPORT THE SHOWIf this episode helped you rethink failure, setbacks, or personal growth, you can support the show by:Subscribing and checking out more episodesSharing it on social media (tag me and I'll respond)Sending it to someone who needs encouragement to keep goingFOLLOW ANDREW COATESInstagram: @andrewcoatesfitnesshttps://www.andrewcoatesfitness.comPARTNERS AND RESOURCESRP Strength App (use code COATESRP)https://www.rpstrength.com/coatesJust Bite Me Meals (use code ANDREWCOATESFITNESS for 10% off)https://justbitememeals.comMacrosFirst – FREE Premium TrialDownload MacrosFirst and during setup select ANDREWKNKG Bags (15% off)https://www.knkg.com/Andrew59676Versa Grippshttps://www.versagripps.com/andrewcoatesTRAINHEROIC – FREE 90-Day Trialhttps://www.trainheroic.com/liftfreeReply to the email you receive (or email trials@trainheroic.com) and let them know Andrew sent you

    From The Heart - A MOMnation Podcast
    Perimenopause Symptoms: Why You Feel Off Even When Tests Look Normal

    From The Heart - A MOMnation Podcast

    Play Episode Listen Later Jun 16, 2026 16:44


    Health and Fitness with ErinIn this episode of Energy Shift With Erin, Coach Erin McDonald tackles a frustration many women face during perimenopause: being told their labs are "normal" while still dealing with brain fog, fatigue, poor sleep, mood changes, and stubborn inflammation.​​Erin shares her personal hormone journey, explains why traditional lab work doesn't always tell the full story, and discusses the importance of tracking symptoms, understanding hormone fluctuations, and looking beyond disease management toward true health optimization. If you've ever felt unheard or confused about what your body is telling you, this conversation is for you.

    Entrepreneur School
    Why We Refused to Launch Our Software the Normal Way

    Entrepreneur School

    Play Episode Listen Later Jun 16, 2026 20:52 Transcription Available


    Here's a confession: I've bought at least a handful of softwares in my life that I've literally never logged into. Not once.So when it came time to launch wAIv to the public, every coaching instinct in my body refused the traditional software playbook. Open the doors, run ads, free trial, hope they convert? Absolutely not. I've watched too many entrepreneurs buy a thing that just sits there, and Andrew and I did not want to build a company on people not using the thing.Instead, we built something I'm calling the most coach-brained software launch you've ever seen: Bot Squad Bootcamp. This episode is the full tour.In this episode, you'll learn:Why the traditional software launch playbook was a hard no for us (and what we designed instead)What a bot squad actually is, and why your bots get noticeably smarter the moment they share contextThe duct tape problem: why your clients shouldn't be the connective tissue between your AI toolsThe real risk of housing your frameworks and IP on platforms you don't controlThe week-by-week build path inside Bot Squad Bootcamp, from gathering your materials to graduating with a live, sellable squadExactly who this is for, who it's not for and a transparent breakdown of what wAIv costs after your first three months>>Resources MentionedBot Squad Bootcamp (doors close June 28, kickoff July 6): https://graviastudio.com/bootcampBook a 20-minute fit call with KellyLast week's episode with Dr. Michelle MazurQuestions? Email kelly@graviastudio.com>>Introducing wAIvThis episode is brought to you by wAIv—our brand-new platform built for online experts who want to securely build and sell AI tools powered by YOUR thinking, YOUR frameworks and YOUR methodology.wAIv helps you create Bot Squads—a suite of AI tools that work together to help your clients implement your expertise faster and with better results than ever before.We're currently rolling out in beta, and you can join the waitlist now to access our AI Tool Launch Playbook, which walks you through exactly how to start thinking about your first Bot Squad—what to put in it, what it will solve for your clients, what to name it, and exactly how to build it.Head to https://waiv-ai.com to get on the list.>>Your Next Steps:

    The Wheel Talk Podcast
    Amanda "Spratty" Spratt's last hurrah

    The Wheel Talk Podcast

    Play Episode Listen Later Jun 15, 2026 54:19


    This week, we go back in time to just before the Spring Classics, when Abby sat down with Amanda "Spratty" Spratt to talk about her final season racing bikes. Normal episodes of the podcast will resume after the Tour de Suisse, which kicks off on Wednesday, June 17th. The five-stage race will feature a few potential Tour de France Femmes avec Zwift contenders, so we will have plenty to discuss next week. Check out the Wheel Talk Newsletter on EscapeCollective.com for a full breakdown of the stages and contenders. 

    Ask Dr Jessica
    Ep 239: Divorce Through a Child's Eyes: What Parents Need to Know with Erica Komisar

    Ask Dr Jessica

    Play Episode Listen Later Jun 15, 2026 38:11 Transcription Available


    Send us Fan MailDivorce is one of the most significant transitions a family can experience—but how does it affect children, and what can parents do to minimize the emotional impact?In this episode, Dr. Jessica Hochman sits down with psychotherapist, psychoanalyst, and bestselling author Erica Komisar to discuss the developmental and emotional effects of divorce on children. They explore why certain ages may be more vulnerable than others, how attachment influences children's reactions to separation, common mistakes parents make during divorce, and practical ways parents can help children feel secure during times of change.They also discuss custody arrangements, co-parenting, dating after divorce, and what children need most from their parents during difficult family transitions.Whether you're navigating divorce yourself or supporting someone who is, this conversation offers thoughtful, compassionate guidance focused on children's emotional wellbeing.About Erica KomisarErica Komisar, LCSW, is a clinical social worker, psychoanalyst, parent guidance expert, and bestselling author. She is the author of Being There: Why Prioritizing Motherhood in the First Three Years Matters, Chicken Little the Sky Isn't Falling: Raising Resilient Adolescents in the New Age of Anxiety, and The Parents' Guide to Divorce: What to Expect, How to Prepare, and How to Move Forward.Learn more about Erica and her work at:Erica Komisar's WebsiteThe Parents' Guide to Divorce:The Parents' Guide to Divorce BookYour Child is Normal is the trusted podcast for parents, pediatricians, and child health experts who want smart, nuanced conversations about raising healthy, resilient kids. Hosted by Dr. Jessica Hochman — a board-certified practicing pediatrician — the show combines evidence-based medicine, expert interviews, and real-world parenting advice to help listeners navigate everything from sleep struggles to mental health, nutrition, screen time, and more. Follow Dr Jessica Hochman:Instagram: @AskDrJessica and Tiktok @askdrjessicaYouTube channel: Ask Dr JessicaIf you are interested in placing an ad on Your Child Is Normal click here or fill out our interest form.-For a plant-based, USDA Organic certified vitamin supplement, check out : Llama Naturals Vitamin and use discount code: DRJESSICA20-To test your child's microbiome and get recommendations, check out: Tiny Health using code: DRJESSICA The information presented in Ask Dr Jessica is for general educational purposes only.  She does not diagnose medical conditi...

    Sleep Space from Astrum
    These Orbits Are Not Normal

    Sleep Space from Astrum

    Play Episode Listen Later Jun 15, 2026 49:19


    This compilation explores the weirdest orbits that could ever exist. We'll explore backwards-orbiting Moons, strange orbits at the outer edge of our Solar System, and theorise how planets could exist with multiple suns. Join us to find out how these weird orbits actually work, and why some don't behave how you'd expect. ▀▀▀▀▀▀Astrum's newsletter has launched! Want to know what's happening in space? Sign up here: ⁠https://astrumspace.kit.com⁠A huge thanks to our Patreons who help make these videos possible. Sign-up here: ⁠https://bit.ly/4aiJZNF

    L'appel trop con
    Garage à cadeaux

    L'appel trop con

    Play Episode Listen Later Jun 15, 2026 3:52


    Quand on change son pare-brise, on a souvent un cadeau : Martin n'en a pas eu, avec le petit garage en bas de chez lui. Alors, il les appelle pour se plaindre … Normal !

    Fruit Grower Report
    Water Levels Improve

    Fruit Grower Report

    Play Episode Listen Later Jun 15, 2026


    Water levels are better than expected following a winter with about half the normal snowpack in the mountains.

    Le Morning du Rire avec Bruno Roblès
    L'Appel Trop Con : Garage à cadeaux

    Le Morning du Rire avec Bruno Roblès

    Play Episode Listen Later Jun 15, 2026 3:52


    Quand on change son pare-brise, on a souvent un cadeau : Martin n'en a pas eu, avec le petit garage en bas de chez lui. Alors, il les appelle pour se plaindre … Normal !

    Narc Con
    Breaking Up with A Narcissist is Far From Normal - How to Explain It To Friends & Family

    Narc Con

    Play Episode Listen Later Jun 14, 2026 26:51 Transcription Available


    #breakup #narcissisticabuse #narcissist Healing from narcissistic abuse takes longer than most people expect—and this is why. This isn't just a normal breakup. Narcissistic relationships involve emotional conditioning, psychological manipulation, and intense highs and lows that create a trauma bond. That's why you can't “just move on.” Recovery isn't about missing someone—it's about rebuilding your confidence, trusting yourself again, and finding your identity after emotional abuse.If you feel misunderstood for not being “over it,” or you're trying to support someone who went through this, this video explains why healing takes time.https://youtu.be/ukV4A2jKUDc• Website & Coaching Enquiries: https:// www.weaponizedlove.com/Coaching & Speaking Engagements:narcscon@gmail.com* Read the Book: Weaponised Love -https://Im.fm/*Listen to my audiobook:Weaponized Love: Understanding How Narcissists Think Is Key to Protect, Heal and Thriveyou can listen to the full audiobook here:https://www.audible.com/pd/Weaponized-Love-Audiobook/B0GFG8TQTQ• Support the Channel: Donate via PayPal - https:// www.paypal.com/paypalme/narcscon?country.x=.Disclaimer: This content is for educational and informational purposes only. It is not a substitute for professional mental health advice, diagnosis, or treatment.NARCCON1Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

    Geek Shock
    Geekshock #842 - Fist Everyone

    Geek Shock

    Play Episode Listen Later Jun 13, 2026 130:05


    Little Sister joins us for a blissful Torgo-less episode as we talk about geeky stuff, including Pickles, Steve unboxes a statue, David's butt, The Boys ending, Masters of the Universe, The Tuner, Krypto buckets, assholes in Vegas, smoking brisket, For All Mankind, Normal, Backrooms, popcorn buckets, Mandalorian and Grogu, Return of the Archmage: OP MC System Apocalypse Regression Litrpg, what Progression Fantasy is, Trekkies/Trekkers, BTK, Doctor Who shakeup, Supergirl's pierced ears, and more.  So pucker up for a fisting, it's time for a Geekshock.

    The KVJ Show
    KVJ Cuts- Normal Or Nope (06-12-26)

    The KVJ Show

    Play Episode Listen Later Jun 12, 2026 9:46


    Putting A Few Tea Spoons Of Bleach In A Bath... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Jon & Chantel
    Condiment Wars

    Jon & Chantel

    Play Episode Listen Later Jun 12, 2026 70:24 Transcription Available


    If you could only keep one, would you choose Ketchup or Ranch dressing? That's the Hot Topic, plus an all-new 2nd Date Update, Normal or Nope, and a movie review of Disclosure Day!

    The Productivityist Podcast
    Letting Go of "Normal" to Finally Try Again (with Steve Kamb)

    The Productivityist Podcast

    Play Episode Listen Later Jun 12, 2026 44:35


    This episode is brought to you by Your Clockwise Week—a personalized weekly structure built around your actual life, not an ideal one. If your week feels full but not fitting, you can learn more at mikevardy.com/yourclockwiseweek.There's a loop most of us know well, even if we've never named it: feel behind, find the thing that's going to fix everything, go all in for a few weeks, get derailed by life, and start over — carrying a little more shame each time. It doesn't matter whether we're talking about fitness, productivity, or building a business. The pattern is the same, and so is the trap. We keep waiting for things to get back to normal so we can try again properly. But what if that version of normal isn't coming back?Steve Kamb is the founder of Nerd Fitness, which has grown over 17 years into a platform that has coached more than 20,000 people one-on-one. His new book, How to Try Again, grew out of that work — specifically from the most universal problem he kept encountering across thousands of conversations: the all-or-nothing mindset. Steve built a four-part framework called PACT — Pause, Accept, Change, Try — to help people break the doom loop and stop waiting for ideal conditions that never arrive.Six Discussion PointsThe pause is the hardest part of PACT not because it requires effort, but because it requires restraint — and our productivity culture has no patience for it. Slowing down feels like falling behind, when it's often the only way to figure out if you're even moving in the right direction."Normal" is not a destination you return to — it's whatever your actual days look like right now, including the chaos, the interruptions, and the laundry on the floor. Waiting for a predictable routine to materialize before you start is a way of never starting.Before you commit to a goal, ask the question most people skip: What if this works? If success means you have to keep doing the thing you hate, you've picked the wrong goal. The reward for getting good at Instagram is that you have to keep doing Instagram.Treating your next attempt like a non-judgmental experiment — part scientist, part detective — removes the weight of outcome and replaces it with curiosity. You're not measuring whether you become the person you admired; you're measuring what you learned about yourself.The doom loop compounds. Every incomplete attempt doesn't just reset the clock; it adds guilt and shame to the pile you're already carrying. Recognizing the loop is the first step to using one of the escape pods Steve calls "half-assing it" — doing the most of the thing you can do today, rather than the ideal version of it.Steve effectively fired himself as CEO of his own company to get back to the work he actually loved — writing. The book that resulted is his most personal project, and it came from applying PACT to his own life: pausing, accepting who he really is, changing his role, and trying again on his own terms.Three Connection PointsHow to Try Again by Steve Kamb — howtotryagain.comNerd Fitness — Steve's 17-year-old community and platform: nerdfitness.comStop Managing Your Time, Start Crafting It — My piece on the TimeCrafting approach, which shares a lot of philosophical ground with Steve's ideas about working within your actual constraints rather than imagined ones: Read it on MediumThe conversation Steve and I had goes back sixteen years, and there's something fitting about the fact that both of us have spent that time learning — the hard way, repeatedly — that the frameworks and tools only work when they're built around the life you're actually living. PACT isn't a productivity system. It's permission to be human and then do something about it. If you've been waiting for the right moment to try again, this might be the episode that helps you stop waiting.If this episode resonated, I'm exploring ideas like these more deeply in my upcoming book, Productiveness. You can follow along as it takes shape at mikevardy.com/productiveness.

    Political Contessa
    Blue Barrels, Broken Systems, Food Fraud, and Election Reform in Massachusetts

    Political Contessa

    Play Episode Listen Later Jun 12, 2026 38:36


    In this week's episode, Jennifer is a guest on Jeff Simone's podcast, "Back to Normal," a prominent voice in Massachusetts Republican circles and the current finance chair for the Mike Minogue gubernatorial campaign. Jeff, who is well known for hosting the "Back to Normal" show and for his previous role as chair of the Massachusetts Republican Party, joins Jennifer for an in-depth discussion of the state's political and ethical landscape. Jeff has been a driving force in advocating for conservative principles, government accountability, and transparent elections across the Commonwealth. Jennifer and Jeff tackle explosive topics, opening with the controversial top-two primary ballot initiative headed for Massachusetts voters in November. Jennifer explains her support for this unconventional election model, despite pushback from both Democratic and Republican insiders, highlighting the overwhelming percentage of unenrolled voters and the potential to disrupt incumbent protection. Jeff counters with concerns about party system erosion and the risks of open primaries. The conversation pivots to a recently uncovered multimillion-dollar food assistance fraud in Massachusetts. They detail how food obtained via EBT cards, food banks, and charitable organizations is shipped in bulk to the Dominican Republic, where it is sold for profit, fueling bipartisan outrage and finger-pointing at the state’s Democratic leadership for lack of oversight. Jennifer and Jeff engage in a blunt critique of legislative complacency and demand action, calling for systemic reform and increased Republican representation to prevent further abuse of taxpayer funds. “Nothing changes unless you vote in different people. That’s it. This all continues. Another more Healey term, another Andrea Campbell term.” ~Jeff Simone This Week on Political Contessa: Massachusetts faces a significant fraud issue with food assistance benefits being illegally exported and sold abroad. The top two primary initiatives are highly polarizing among political insiders of both major parties. Unenrolled voters constitute the largest voting bloc in the Commonwealth. Incumbent protection and legislative perks are under scrutiny for perpetuating a lack of accountability. There is fierce debate over whether opening primaries increases or erodes democratic representation. Jennifer argues the top-two system offers better chances for minority parties and increased voter participation. Jeff contends that systemic gaming and open primaries weaken party identities and muddle voter intent. Both agree urgent reforms are needed and see electing more Republicans as pivotal to meaningful change. Connect with Jeff Simone: Follow Jeff Simone on X (Twitter): @Enfernassor Back to Normal show: [Contact via Mass GOP] Mike Minogue for Governor: [Mike Minogue Campaign Site (for upcoming appearances and campaign information)] Resources Mentioned: Muckraker.org (investigative reporting on food assistance fraud) Massachusetts Republican Party: Official website Political Contessa: politicalcontessa.com Awaken Your Inner Political Contessa Thanks for tuning into this week’s episode of Political Contessa. If you enjoyed this episode, please subscribe and leave a review wherever you get your podcasts. Spotify I Stitcher I Apple Podcasts I iHeart Radio I TuneIn I Google Podcasts Be sure to share your favorite episodes on social media. And if you’ve ever considered running for office – or know a woman who should – head over to politicalcontessa.com to grab my quick guide, Secrets from the Campaign Trail. It will show you five signs to tell you you’re ready to enter the political arena.See omnystudio.com/listener for privacy information.

    TD Ameritrade Network
    Is Bitcoin 'Broken?' Michael Terpin Sees Volatility as Normal

    TD Ameritrade Network

    Play Episode Listen Later Jun 12, 2026 5:08


    Michael Terpin, author of "Bitcoin Supercycle," makes the case that Bitcoin investors don't need to be worried about the cryptocurrency's 50% sell-off since last October. He attributes the volatility as normal in a four-year halving cycle. Michael also outlines what he sees ahead for "Bitcoin summer" and how cryptocurrencies impact the Fed's path forward on interest rates. ======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

    Health By Heather Hirsch
    What is a Normal Hormone Therapy Journey?

    Health By Heather Hirsch

    Play Episode Listen Later Jun 12, 2026 26:59


    Navigating your hormone replacement therapy journey isn't a one-stop shop, and after treating thousands of women, I've found that 95% of you will need more than a few visits to truly find your balance. In this video, I break down the three common paths, the Titrator, the Superstar, and the Highly Sensitive, to help you identify your own experience and understand why tweaking and titrating is a normal, necessary part of the process. Whether you're dealing with perimenopause shifts, pharmacy shortages, or unexpected sensitivities, I'm here to show you that while the journey is unique for everyone, you are definitely not alone.

    The Drive By
    The Drive By-Episode 384-What's Normal Anymore? Well, Nothing Going On Right Here, Right Now!

    The Drive By

    Play Episode Listen Later Jun 12, 2026 50:16


    In this Episode, we ask a simple question: What's normal anymore? Because if what's happening in Canada right now is considered normal, then normal needs a new definition. From rising costs and political spin to policies that somehow make less sense the more they're explained, we look at the strange new reality Canadians are expected to accept without question. Nothing to see here, folks... just a perfectly normal country doing perfectly normal things. Right? Riiiiiiight! This Episode is Sponsored By: www.lesdeliceslafrenaie.com  Montreal's Best Bakery/Pastry Shop with 7 locations! "Simply Delicious" IG: @deliceslafrenaie @lafrenaiebrossard @lafrenaiemagog @lafrenaiemontrealouest  @lafrenaiesaintejulie @lafrenaiepointeclaire @lafrenaierosemere Win up to $100 in Freeplay! (Exclusive to Drive By Listeners) Spin To Win Now! Go to www.playground.ca/driveby GOOD LUCK! IG: @playgroundyul @playgroundpoker Playground is Canada's premier gaming and entertainment destination with over 1100 gaming machines, 65 poker tables, and three restaurants.  Fans Choice: Voted- Best Poker Room in the World! The Drive By® Podcast is Brought to you by: www.ownspace.com *the views and opinions expressed on this podcast are of the speakers and do not necessarily reflect the views or positions of paid sponsors. The Drive By-Music-Intro/Extro https://open.spotify.com/track/2tAF0OfAhHdY76D9yCZ0T7?si=12de8dcd0d904211                          

    Poder para Cambiar con Jason Frenn
    ¿Es normal que mi esposo me insulte en discusiones y cómo enfrentarlo?

    Poder para Cambiar con Jason Frenn

    Play Episode Listen Later Jun 12, 2026 56:23


    En el programa de hoy hablamos sobre cómo el amor y el respeto son esenciales para un matrimonio sano y cómo su falta puede afectar la comunicación y el corazón. Acompañamos a nuestros oyentes en situaciones de conflictos conyugales, límites con hijos adultos, relaciones familiares difíciles, inseguridades personales y cómo reconectar con los hijos adolescentes. Un espacio para aprender a comunicarse con sabiduría, restaurar vínculos y crecer en relaciones más sanas con la ayuda de Dios.¿Es normal que mi esposo me insulte en discusiones y cómo enfrentarlo?¿Mi pasado en brujería puede afectar la condición de mi hijo?¿Debo permitir que mi sobrino regrese a vivir conmigo?¿Soy mal padre por no querer que mi hijo adulto regrese a casa?¿Cómo manejar el carácter explosivo y verbalmente agresivo de mi esposa?¿Cómo vencer el miedo de manejar y ganar seguridad?¿Cómo conectar con un hijo adolescente que no muestra interés?¿Cómo vencer la inseguridad al hablar con otras personas?

    Movies That Don't Suck and Some That Do
    Episode 408 - Normal & Backrooms

    Movies That Don't Suck and Some That Do

    Play Episode Listen Later Jun 12, 2026 72:45


    New episode. New talk. Real talk. First, after the intro, they dip their toes into 2025 and talk Normal starring Bob Odenkirk as an interim Sheriff in the fictional town of Normal, Wisconsin. As you can guess, Normal is a misnomer. Then, after news, they talk A24's monster hit Backrooms.  Based on the youtube show, this scifi horrror stars Chiwetel Ejiofor, Renate Reinsve and Lukita Maxwell.  Is Normal extradodinary? Is Backroom gonna make you wish you were backathome? Listen and find out, you little jerks. Oh yeah, if you want a 100% free sticker (we even pay postage) send us a message! www.moviesthatdontsuck.net https://w2mnet.com/category/podcasts/movies-that-dont-suck-and-some-that-do www.patreon.com/moviesthatdontsuck https://www.bonfire.com/movies-that-dont-suck-and-some-that-do-logo/ FB: facebook.com/moviesthatdontsuckpodcast Bluesky: @moviesthatdontsuck.bsky.social Instagram: @MTDSpodcast https://www.youtube.com/@moviesthatdontsuckpodcast

    The Mindset & Motivation Podcast
    How to Make "Success" Feel Normal

    The Mindset & Motivation Podcast

    Play Episode Listen Later Jun 11, 2026 16:38


    Freedom Live is a 3-day live experience in Austin for high performers ready to break through the patterns, beliefs, and identity blocks keeping them from the next level. Join the waitlist: https://freedomwaitlist.com/ Feeling stuck? It's time to take back control. If you're ready to master your mind and create real, lasting change, click the link below and start transforming your life today.

    The Luke and Pete Show
    Wall-to-Wall Muck

    The Luke and Pete Show

    Play Episode Listen Later Jun 11, 2026 27:22


    Normal people are being price-gouged for paddling pools while conspiracy theorists insist that sun cream is population control. Summer is well and truly here.Meanwhile, the White House is tweeting about the anniversary of a gorilla's untimely death and appears to be attaching itself to obscure Scottish electronic music. It begs the question: do right-wingers understand art?After that debate, it's time for emails. No, we are NOT off to Mars.Send us your latest stories, questions and comments here: hello@lukeandpeteshow.com.The Luke and Pete Show is the sometimes ridiculous, always funny podcast with Luke Moore and Pete Donaldson: two men who have time on their hands and a good idea of how to waste it. Subscribe to get your comedy podcast fix every Monday and Thursday. Hosted on Acast. See acast.com/privacy for more information.

    Wits & Weights: Strength and Nutrition for Skeptics
    5 Signals That Your Body's "Off" Even When Your Labs Are Normal (Dr. Stephen Cabral) | Ep 476

    Wits & Weights: Strength and Nutrition for Skeptics

    Play Episode Listen Later Jun 11, 2026 51:53 Transcription Available


    You're lifting weights. You're eating well. Your labs look “normal.” So why do you still feel exhausted, bloated, wired at night, moody, or like your body is aging faster than it should?Dr. Stephen Cabral helps us decode why fatigue, bloating, poor sleep, and mood swings can show up even when your labs look fine. We talk about the five signals your body sends through sleep, energy, digestion, mood, and skin, plus how they connect to hormone health, metabolism, inflammation, and recovery.You'll learn why sleep comes first, how digestion can drain energy, why stress and gut issues can affect mood, and how to build a rhythm that supports evidence-based nutrition, lifting weights, and long-term wellness.Join Eat More Lift Heavy to build strength, lose fat, and learn what works for your body, 1 week at a time. Learn to eat more and lift heavy with confidence. Timestamps:0:00 – Five signals your body sends2:10 – Dr. Cabral's personal health journey8:05 – Foundations before advanced protocols12:42 – Sleep as the first lever21:14 – Energy, cortisol, and daily rhythm27:44 – Digestion, bloating, and gut signals35:32 – Mood, inflammation, and overwhelm40:06 – Skin, hair, and biological age47:00 – The weekly rhythm reset actionEpisode resources:Website: stephencabral.com Podcast: The Cabral ConceptFacebook: @drstephencabral Instagram: @stephencabral YouTube: @stephencabral 

    My Crazy Family | A Podcast of Crazy Family Stories
    What Does a Psychotherapist Hear When Jesse Ridgway Says “I'm Normal”?

    My Crazy Family | A Podcast of Crazy Family Stories

    Play Episode Listen Later Jun 11, 2026 18:25


    On a livestream, Jesse Ridgway said, “I'm glad my dad didn't terminate me, but I'm normal.” That sentence — delivered in the middle of a firestorm about his unborn child — tells a psychotherapist something very specific. Jesse Ridgway has staged events for attention his entire career. Four years of fake family violence. A platform that burned through a million users. And now a pregnancy announcement that may or may not be real, from a man whose record is built entirely on making people believe things that didn't happen.Psychotherapist Shavaun Scott breaks down what she hears in that quote, what the clinical escalation pattern looks like across Ridgway's career, and what a framework called Munchausen by Internet reveals about someone who fabricates crises online to harvest sympathy and attention. If Jesse Ridgway's career is a case study, what is the diagnosis?Join Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/ Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1 Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/TrueCrimePodThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.#JesseRidgway #McJuggerNuggets #PsychoSeries #HiddenKillers #TrueCrime #InfluencerExposed #Narcissism #StoryFire #Exposed #MunchausenByInternet

    Hidden Power: A Pokemon Podcast
    Ranking All 134 NORMAL Type Pokémon

    Hidden Power: A Pokemon Podcast

    Play Episode Listen Later Jun 11, 2026 169:23


    Use code HIDDENPOWER to get 5% Off Pokemon Cards & more at https://awesomeccg.com/pages/hidden-power

    JNIS podcast
    Endovascular shunting for normal pressure hydrocephalus: safety trial insights with Professor Adel Malek

    JNIS podcast

    Play Episode Listen Later Jun 11, 2026 25:40


    Evaluating the 90-day safety and technical feasibility of a percutaneous transvenous approach represents a critical milestone for routing cerebrospinal fluid (CSF) – the clear liquid that cushions the brain and spine – directly into the venous system. In this episode, JNIS Editor, Dr. Michael Chen, talks with corresponding author Professor Adel Malek (Tufts Medical Center, Boston) (1) to discuss his high-impact paper, "Safety of endovascular shunting for normal pressure hydrocephalus from a prospective, multicenter, single-arm study”. They discuss the results of this 66-patient, prospective trial, exploring how the novel eShunt system accesses the cerebellopontine angle cistern to drain CSF and relieve pressure.  Please subscribe to the JNIS podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/4aZmlpT) or Spotify (https://spoti.fi/3UKhGT5). We'd love to hear your feedback on social media - @JNIS_BMJ. (1) Neurosurgeon Adel Malek, MD, PhD. Chief of the Cerebrovascular and Endovascular Division in the Department of Neurosurgery, Tufts Medical Center; Professor of Neurosurgery, Tufts University School of Medicine, Boston, USA. The JNIS Podcast is produced by Letícia Amorim, and is edited by Pritesh Kapadia.  

    Les Grandes Gueules
    Patrick Bruel va pouvoir remonter sur scène : normal ? - 11/06

    Les Grandes Gueules

    Play Episode Listen Later Jun 11, 2026 13:44


    A 10h, ce jeudi 11 juin 2026, les GG : Barbara Lefebvre, prof d'histoire-géo, Sandrine Pégand, avocate, et Emmanuel de Villiers, entrepreneur, débattent de : "Patrick Bruel va pouvoir remonter sur scène : normal ?".

    The Podiatry Business Podcast
    Episode 194; Fear Is Normal. Staying Stuck Is Optional.

    The Podiatry Business Podcast

    Play Episode Listen Later Jun 11, 2026 16:04


    Fear is a normal part of growth—especially when you're running a podiatry clinic.When you're working long days, carrying the pressure of patients and payroll, and still not seeing the income or freedom you expected, change can feel risky. But staying the same has a cost too: more hours, more stress, and the same results. In this episode, we'll unpack why fear shows up, why it doesn't mean “stop,” and the plan that helps you move forward anyway.

    Multiplier Mindset® with Dan Sullivan
    Not Being Normal Is Your Biggest Advantage, with Andy Howard

    Multiplier Mindset® with Dan Sullivan

    Play Episode Listen Later Jun 10, 2026 20:21


    Andy Howard always knew he didn't think like everyone else, and school confirmed it. Today, he runs Karuna Impact, a niche property business that converts underused commercial buildings into homes and channels a third of its profits to fight child bed poverty. Discover how Strategic Coach® helped Andy transform discomfort and loss into clarity, confidence, and a powerful freedom of purpose. Here's some of what you'll learn in this episode:Why Andy's entrepreneurial mind didn't fit formal education.What Andy started doing after school that finally felt energizing.How a neglected niche in property became a huge growth opportunity.How Andy has gained confidence and clarity through Strategic Coach.What sparked Andy's renewed sense of purpose as an entrepreneur. Show Notes: Many successful entrepreneurs don't thrive in school, so they use their own experience as their real education. Most coaching programs focus on goals and tactics; Strategic Coach focuses on expanding your freedom. Freedom isn't handed to you—you earn it through the entrepreneurial journey. To be free in any area of life, you first need freedom over your time. As you grow your personal freedom, you naturally create greater value for others. For many entrepreneurs, work loses its energy once it feels routine. Big opportunities often live in niches that most people overlook. Social impact and company profitability aren't mutually exclusive; a well-designed business can achieve both. Strategic Coach thinking tools help you get crystal clear on your vision and the people needed to achieve it. Every Program Coach is an entrepreneur, so they coach from real-world experience, not theory. Finding a community of like-minded entrepreneurs makes it easier to take risks and pursue bigger freedoms. Clarifying your freedom of purpose gives you the motivation to keep growing long after you've hit your initial goals. Resources: Karuna Impact The Kolbe A™ Index The Impact Filter® The 4 C's Formula by Dan Sullivan Who Not How by Dan Sullivan with Dr. Benjamin Hardy The 4 Freedoms That Motivate Successful Entrepreneurs Everything Is Created Backward by Dan Sullivan

    The Daily Pep! | Rebel-Rousing, Encouragement, & Inspiration for Creative & Multi-Passionate Women

    In today's episode I'm sharing two things that can help you if you find yourself facing the mid-year wobbles.

    normal letters acast rebellions midyear merlin rebel rousers daily pep couragemakers couragemakers podcast
    The Black Dog Podcast
    The Invisible man

    The Black Dog Podcast

    Play Episode Listen Later Jun 10, 2026 130:49


    No Elton this week but we do have Jim giving some good advice on executing wills, Darren spending time in the Backrooms with the Masters of the Universe, while Lee is simultaniously In the Grey, Cold Storage and is utterly Normal... Plus all three give their thoughts on Spider-Noir After that its on to this weeks film. A tense metaphor for abusive, controlling, toxic relationships the 2020 movie The Invisible Man Media Discussed This Week The Backrooms - Theatrical Release Masters of the Universe - Theatrical Release Cold Storage - Amazon VOD Normal - VOD In The Grey - Amazon VOD The Invisible man - Netflix

    Let's Talk Wellness Now
    Episode 268 – Mold+Lyme+Genetics: The Root Cause Most Doctors Miss

    Let's Talk Wellness Now

    Play Episode Listen Later Jun 10, 2026 82:03


    Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

    The Fat Doctor Podcast
    When "Everything's Normal" Isn't Good Enough

    The Fat Doctor Podcast

    Play Episode Listen Later Jun 10, 2026 28:06 Transcription Available


    Send us Fan MailWhen your blood tests come back normal and your doctor sends you on your way, that's not a diagnosis – that's a dismissal. In this episode, I follow Priya, a self-employed autistic woman in her late 30s whose 18 months of worsening fatigue, hair loss, skin changes, and irregular periods have been met with advice to exercise more and download a mindfulness app.I walk you through why "normal bloods" and "everything's fine" are not the same thing, which conditions are routinely missed in fat patients, and what it actually looks like when a doctor does their job properly.Because basic care isn't heroics. It's just medicine.Got a question for the next podcast? Let me know!Connect With MeBUY THE BOOK: Never suffer through another through another weight loss lecture from your doctor againJOIN THE NO WEIGH MOVEMENT: Get a free script when you sign upTHE WEIGHTING ROOM: Community with a neurodivergent flavour. **BOOK CLUB** exclusive to Weighting Room members. BOOK A CONSULTATION: For the ultimate transformation in your healthcare journeyEXPLORE THE MASTERCLASS LIBRARY: Become an expert in your condition and the weight inclusive ways to manage itFREE GUIDES:Evidence-based, not diet nonsenseFind me on Instagram, YouTube, and LinkedIn.

    What The Dementia
    177 | Q&A: Is This Normal For Dementia?

    What The Dementia

    Play Episode Listen Later Jun 10, 2026 14:18


    In this episode, we will discuss common dementia-related behaviors and symptoms caregivers often wonder about, and how to tell when something may be part of the condition versus when it could signal another issue. We'll go through six real caregiver questions, covering topics like incontinence, changes in mood, waking up disoriented, shifts in taste preferences, loss of appetite, and repeating the same story.‍Questions answered: Incontinence — is it normal?Why are they so mean, is this normal?Is it normal for someone with dementia to wake up disoriented?Is it normal for their taste preferences to change? Is repeating the same story over and over in the same conversation a normal symptom of dementia?Mom says she's not hungry and she hasn't eaten in four days, is this normal with dementia?CONNECT, GET RESOURCES, LEARN MORE, + SIMPLIFY YOUR CARE JOURNEY:LinkTree | ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.letsbambu.com/b/linktree⁠⁠⁠⁠⁠⁠⁠⁠⁠MUSIC CREDIT: Listen To SpillageVillage - Tropical Landing Pop Songs At Looperman.com DISCLAIMER: The information contained in Bambu Care LLC's website, blog, emails, programs, services and/or products is for educational and informational purposes only. While we draw on our prior professional expertise and background in other areas, you acknowledge that we are supporting you in our role exclusively as a Dementia Care Consultant. By participating in Bambu Care, LLC's website, blog, emails, programs, services and/or products, you acknowledge that we are not a licensed psychologist, professional counselor, or medical doctor. We in no way, diagnose, treat, or cure any illnesses or diseases. Dementia Care Consulting is in no way to be construed or substituted as psychological counseling or any other type of therapy or medical advice. The information provided by Bambu Care, LLC also does not constitute legal or financial advice nor is intended to be. Dementia Care Consulting is not a substitute for the services of a CPA or attorney.

    ReInvent Healthcare
    The Vaginal Microbiome: Why Hormones Aren't Working and What You're Missing

    ReInvent Healthcare

    Play Episode Listen Later Jun 10, 2026 43:17 Transcription Available


    You've increased estrogen.You've supported the gut.You've cleaned up the protocol.And… she's still dealing with dryness. recurrent UTIs., and discomfort that keeps coming back.At some point, it stops being a hormone conversation.When labs look “fine” and symptoms persist, adding more support doesn't fix the problem. It just exposes it.In this episode, Dr. Ritamarie sits down with Dr. Anna Cabeca to look at a pattern that gets missed in conventional and functional care: the vaginal microbiome.This is NOT a side topic but a primary driver.They walk through what happens when Lactobacillus balance is disrupted, why vaginal pH shifts matter more than most practitioners realize, and how these changes can create symptoms that look hormonal but don't respond to hormone-based approaches.You'll start to see why some cases don't resolve…and what to look at next when they don't.What's Inside This Episode?Normal estrogen… but persistent drynessWhy UTIs keep coming backWhen pH—not hormones—is the issueThe key Lactobacillus strains that matterHow antibiotics and HRT disrupt the ecosystemUrgency and leakage that aren't a bladder problemThe link to fertility, aging, and tissue healthWhy systemic protocols fail when the issue is localResources and LinksDownload the Full TranscriptDownload our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes hereDr Anna's Resources and LinksDr Anna's Website: https://drannacabeca.comCheck out Dr Anna's productsFind her on Social Media FacebookYouTube: The Girlfriend Doctor: TikTokPodcast Labs & Testing Mentioned in This EpisodeThese tools go beyond traditional testing (HPV, chlamydia, gonorrhea, trichomonas) and help assess overall vaginal microbiome balance, including beneficial Lactobacillus species.MDL (Medical Diagnostic Laboratories) - Vaginal testing that includes both pathogenic organisms and beneficial bacteriaBiomeFX Vaginal Microbiome Kit - Advanced microbiome analysis to assess vaginal bacterial balanceTiny Health Vaginal Microbiome Test - At-home testing option for evaluating vaginal microbial healthGuest BioAnna Cabeca, DO, OBGYN, FACOG, is best selling author of The Hormone Fix and Keto-Green 16 and MenuPause. Dr. Anna is triple-board certified and a fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She holds special certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She lectures frequently on those topics and shares the secret behind the ebb and flow of intimacy as she demystifies the fascinating hormonal changes over time. She will help you discover how the “love hormone”, Oxytocin can breathe life into your relationship, and how Cortisol can take it away - and how the delicate balancing act of those hormones can reignite your libido and support a healthy relationship, most importantly the one you have with yourself.She is sassy, blunt, speaks from the heart and has a wonderful sense of humor, and this is why we call her The Girlfriend Doctor, because everyone needs a friend like her! She has personally developed natural products to help women balance hormones and thrive through menopause including the highly acclaimed Julva® cream for the vulva and MightyMaca® Plus, a powerful superfood blend. She lives in Dallas with her daughters, horses and dogs.

    BloodBath w/ Annie, & Esther, & Khalyla
    Taylor Tomlinson & Sophie Buddle Can't Believe This Was Normal

    BloodBath w/ Annie, & Esther, & Khalyla

    Play Episode Listen Later Jun 9, 2026 75:29


    BTS, BONUS CONTENT AND MORE! Only on Patreon: https://www.patreon.com/c/TrashTuesdayPodcast GET IT BEFORE ITS GONE - https://trashtuesday.myshopify.com/ Besties Sophie Buddle and Taylor Tomlinson are in the building to talk about talk spray tans, nightmares, high school reunions, turning 34, grief, and questionable age-gap relationships. We're also diving headfirst into a bridesmaids toxic-as-hell wedding Reddit saga. #jemily MORE TAYLOR!https://taylortomlinsoncomedy.com/ https://www.instagram.com/taylortomlinson MORE SOPHIE!https://www.sophiebuddlecomedy.com/https://www.instagram.com/sophbuds/ Thank you to our sponsors:Thank you to HERS - Visit Https://forhers.com/trashtuesday to get personalized, affordable care that gets you. Thank you to SKIMS - Shop Everyday Cotton, and all of my favorite bras and underwear at http://www.skims.com/trashtuesday #skimspartnerThank you to LOLA BLANKETS - Get 40% off select Lola Blankets products at Lolablankets.com by using code TRASHTUESDAY at checkout. Experience the world's #1 blanket with Lola Blankets https://lolablankets.com/ Watch every episode of the Hulu Original series Alice and Steve on Hulu and Hulu on Disney Plus for bundle subscribers. *Listen to Esther's New Solo Pod!* https://www.esthersgrouptherapy.substack.com FOLLOW TRASH ON SOCIALS: Instagram: https://www.instagram.com/itstrashtuesday Tiktok: https://www.tiktok.com/@itstrashtuesday MORE ESTHER:TikTok: https://www.tiktok.com/@esthermonster Instagram: https://www.instagram.com/esthermonster/ MORE KHALYLA:Instagram: https://www.instagram.com/khalamityk/ Tigerbelly Podcast: https://www.youtube.com/@UCIyIoM_Nd8HtY19fuR_ov2A PRODUCTION:Studio Ten42: https://www.instagram.com/studioten42/ Guy Robinson: https://www.instagram.com/grobfps/ Arielle Jade (Editor): https://www.instagram.com/jade.rabbit.cce/ Elisa Hernandez Kohler: https://www.instagram.com/ellie.lianna/ Megan Clements: https://www.instagram.com/egggymeg/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    CALLING HOME with Whitney Goodman, LMFT
    Are Adult Children Really Cutting Off Parents for Normal Mistakes?

    CALLING HOME with Whitney Goodman, LMFT

    Play Episode Listen Later Jun 9, 2026 39:52


    When therapists say adult children are cutting off their parents for “normal parenting mistakes,” they're almost never specific about what that means. Whitney asked 300+ people to define a normal parenting mistake and the responses said it all. The episode explores what happens when there's no repair, no accountability, and no willingness to engage with a parenting misstep, unintentional or not, that genuinely hurt. Whitney Goodman is a Licensed Marriage and Family Therapist (LMFT) and the founder of Calling Home, a membership community that helps people navigate complex family dynamics and break harmful cycles.Have a question for Whitney? Send a voice memo or email to whitney@callinghome.coJoin the Family Cyclebreakers Club: https://callinghome.coFollow Whitney on Instagram | sitwithwhitFollow Whitney on YouTube | @whitneygoodmanlmftOrder Whitney's book, Toxic Positivity: https://sitwithwhit.com/toxic-positivitySign up for updates on Whitney's new book: https://cmnyyv4kpyt.typeform.com/to/PHMzjy0oThis podcast is for informational purposes only and is not a substitute for professional mental health advice. Hosted on Acast. See acast.com/privacy for more information.

    The Official Red Chip Poker Podcast
    Realistic Expectations For Your Poker Decisions · S8E12

    The Official Red Chip Poker Podcast

    Play Episode Listen Later Jun 9, 2026 22:06


    Any #poker session you play can be thought of as a series of decisions. The "correct" decision in any spot, such as whether to bet and how much, in principle has an objectively-correct answer. This has some players erroneously seeking perfection.   In the real world, the information you use to make each decision contains uncertainty. You simply do not know the precise range of your opponent, and even if you did, a precise EV calculation in real time is not a feasible goal. Make the best decision you can with the available information, but accept that your goal is to be good, not perfect.   TIMESTAMPS 0:00 Introduction: Certain Uncertainty in Poker 0:42 The Myth of Perfect Decision Making 1:30 Why Professional Players Don't Always Know What to Do 3:06 Quest for Perfection vs Reality 4:47 Three Areas Where Uncertainty is Normal 5:23 Area 1: Can You Ever Know You're a Winner? 7:08 Area 2: Understanding Villain Ranges 9:43 The Ranging Process is Just an Educated Guess 11:42 Area 3: Expected Value Calculations 12:42 The Limitations of EV Calculations 15:12 Long-Term EV vs Single Hand EV 18:21 Being Better Than Average is Enough 20:07 Embrace Uncertainty to Improve Your Game   RELATED LINKS The Low-Stakes Poker Playbook: https://redchippoker.com/low-stakes-poker-playbook/ SplitSuit Poker Workbooks: https://www.splitsuit.com/poker-workbooks Generating Profit In Multiway Pots: https://redchippoker.com/profit-from-multiway-pots/ Play Better Poker Through EV Modeling: https://youtu.be/zvRTqcJ7DHY?si=i_tZRyP3JBOQ-TCm   **JOIN US ON DISCORD** Join our free poker Discord today: https://redchippoker.com/discord

    Parenting Teens with Dr. Cam
    How Parents Are Accidentally Damaging Their Teen's Mental Health

    Parenting Teens with Dr. Cam

    Play Episode Listen Later Jun 9, 2026 38:13 Transcription Available


    Are today's teens experiencing a true mental health crisis—or are parents being encouraged to label normal adolescent struggles as disorders? In this thought-provoking episode of the Parenting Teens with Dr. Cam Podcast, adolescent psychologist sits down with renowned child and adolescent psychiatrist, author of Searching for Normal, to unpack the rising diagnoses of ADHD, anxiety, depression, and autism in teens. Parents today are overwhelmed trying to determine when teenage mood swings, defiance, anxiety, and emotional outbursts are “normal” and when they signal something more serious. Dr. Timimi challenges the growing trend of pathologizing ordinary adolescent behavior and explains why over-labeling teens may actually hurt resilience, confidence, and emotional growth. If you're worried about your teen's mental health, struggling with constant conflict, or wondering whether therapy, medication, or diagnosis is the right next step, this episode offers a refreshing and deeply practical perspective. Learn how to support your teen without overreacting, how to identify true mental health red flags, and why strengthening your relationship with your teen may be more powerful than trying to “fix” them. WHAT YOU'LL LEARN IN THIS EPISODE How to tell the difference between normal teenage behavior and serious mental health concerns Why anxiety, moodiness, and teen defiance are often part of healthy adolescent development The hidden dangers of over-diagnosing ADHD, anxiety, and depression in teenagers How parents can build resilient, emotionally healthy teens without overprotecting or over-controlling  

    En esencia con Radhi Yoga
    388. Es normal y sano pensar diferente

    En esencia con Radhi Yoga

    Play Episode Listen Later Jun 9, 2026 41:21


    Solemos pensar que nosotros tenemos la razón y el otro bando o la otra persona está errada 100% y la gran mayoría de veces, ninguno tiene del todo la razón y ninguno está 100% errado. Normalmente las situaciones se pueden interpretar desde diferentes lentes, dependiendo de cómo estemos mirando la realidad. Hoy quiero recordarte eso, que podemos pensar diferente y aún así, seguir queriendonos y seguir entendiendonos. ¡Espero te inspire!

    Lenguas Calvas Podcast
    Rápida y Quesúa | #354 Lenguas Calvas Podcast

    Lenguas Calvas Podcast

    Play Episode Listen Later Jun 8, 2026 58:39 Transcription Available


    ¡Feliz lunes de lenguas! Bienvenidos a su espacio favorito para curarse con las desgracias ajenas, echar voches y escuchar los peores consejos de la internet (recuerden que esto es puro entretenimiento y comedia).  Hoy Chris nos cuenta su rodaje bajo el calor de Salinas y Laura su viaje al Cibao. Además, debatimos: ¿Qué tan psycho es que te llamen por videollamada de Instagram sin avisar? ¡Se prendió el live!  

    Ask Dr Jessica
    Ep 238: Your Child Doesn't Need to Read Early: What Really Matters for Literacy, with Ruth Rothfeld-Hochman SLP (my Mother-in-Law)

    Ask Dr Jessica

    Play Episode Listen Later Jun 8, 2026 38:39 Transcription Available


    Send us Fan MailMany parents worry about reading: Is my child reading early enough? What if my child doesn't like books?In this episode of Your Child Is Normal, Dr. Jessica sits down with a very special guest—her mother-in-law, a speech-language pathologist and reading specialist with decades of experience helping children develop language, literacy, and learning skills.Together they discuss the difference between speech and language, why comprehension matters more than reading words early, how parents can make reading aloud more meaningful, and the signs that may suggest a child needs additional support.They also discuss dyslexia, stuttering, tongue ties, audiobooks, screens, homework, sustained attention, and why reading should never feel like a test.This conversation is full of practical advice, strong opinions, and reassuring reminders that every child develops on their own timeline.For questions or resources, contact:languageisaccess@gmail.comFollow Ruth on Instagram @languageisaccessYour Child is Normal is the trusted podcast for parents, pediatricians, and child health experts who want smart, nuanced conversations about raising healthy, resilient kids. Hosted by Dr. Jessica Hochman — a board-certified practicing pediatrician — the show combines evidence-based medicine, expert interviews, and real-world parenting advice to help listeners navigate everything from sleep struggles to mental health, nutrition, screen time, and more. Follow Dr Jessica Hochman:Instagram: @AskDrJessica and Tiktok @askdrjessicaYouTube channel: Ask Dr JessicaIf you are interested in placing an ad on Your Child Is Normal click here or fill out our interest form.-For a plant-based, USDA Organic certified vitamin supplement, check out : Llama Naturals Vitamin and use discount code: DRJESSICA20-To test your child's microbiome and get recommendations, check out: Tiny Health using code: DRJESSICA The information presented in Ask Dr Jessica is for general educational purposes only.  She does not diagnose medical conditi...

    Dr. Joseph Mercola - Take Control of Your Health
    Are You Taking Vitamin D at the Wrong Time?

    Dr. Joseph Mercola - Take Control of Your Health

    Play Episode Listen Later Jun 6, 2026 6:42


    Taking vitamin D at midday with your largest meal improves absorption and helps your body use it more effectively for mood, sleep, and brain function Normal vitamin D blood levels don't guarantee results because your body needs to convert it into an active form that your cells can actually use A large portion of people struggle with this activation step, which explains why symptoms like fatigue and poor sleep persist despite supplementation Sunlight remains the most effective way to produce vitamin D naturally; removing seed oils improves your ability to tolerate midday sun safely Pairing vitamin D3 with magnesium and vitamin K2, tracking your levels, and staying physically active helps your body activate and maintain vitamin D year-round

    Behind the Bastards
    Part Two: Mark Fuhrman: The Most Racist Cop, or Merely Normal Racist Cop?

    Behind the Bastards

    Play Episode Listen Later Jun 4, 2026 54:43 Transcription Available


    Robert concludes the story and, thankfully, the life of Mark Fuhrman, after discussing his most famous moment: the OJ Simpson trial.See omnystudio.com/listener for privacy information.