Sounds Physiological

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Sounds Physiological is a podcast from The Journal of General Physiology focusing on groundbreaking discoveries in cellular and molecular physiology. Each episode features interviews with pioneering physiologists from across the globe.

Rockefeller University Press


    • Sep 28, 2015 LATEST EPISODE
    • infrequent NEW EPISODES
    • 13 EPISODES


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    Latest episodes from Sounds Physiological

    A well-channeled journey from heart to brain: Dick Tsien

    Play Episode Listen Later Sep 28, 2015


    A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

    Why we don’t twitch when we smoke: Henry Lester

    Play Episode Listen Later Aug 24, 2015


    A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording. Download PDF transcript Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs

    Calcium signaling in the heart: Don Bers

    Play Episode Listen Later Jul 27, 2015


    A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes. Download PDF transcript Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase

    Did Alan Hodgkin dream of calcium sparks? Eduardo Ríos

    Play Episode Listen Later May 25, 2015


    A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay. Download PDF transcript Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin

    Getting from “This can’t be right” to “Of course”: Paul Greengard

    Play Episode Listen Later Apr 27, 2015


    A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research. Download PDF transcript Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3

    Fleeing complexity: Chris Miller

    Play Episode Listen Later Mar 30, 2015


    A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics. Download PDF Transcript Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers

    Jumping into the unknown: Rich Lewis

    Play Episode Listen Later Feb 23, 2015


    A conversation with Richard Lewis on electrical resonance in hair cells, channels and signals in T cells, papayas in the lab, and following your nose. Download PDF transcript Key words: calcium, T cell, Hair cell, Papain, Orai, STIM, CRAC channels

    Molecular hermeneutics and unusual sorbets: Barbara Ehrlich

    Play Episode Listen Later Jan 26, 2015


    A conversation with Barbara Ehrlich on calcium signaling, interpreting Truth, and what’s wrong with green apple-wasabi sorbet. Download PDF transcript Key words: calcium, IP3 receptor, ryanodine receptor, polycystin-2, paramecium, molecular hermeneutics, taxol, lithium, NCS-1, peripheral neuropathy

    In search of the unexpected: David Clapham

    Play Episode Listen Later Dec 29, 2014


    A conversation with David Clapham, on where scientific curiosity can take you. Download PDF transcript Key words: calcium, sperm, mitochondria, cilia, TRPM7, GPCRs, CRAC, noise analysis, patch clamp, channels

    Investigating calcium compartmentation and dynamics: Tullio Pozzan

    Play Episode Listen Later Nov 24, 2014


    A conversation with Tullio Pozzan on calcium compartmentation and dynamics, and signaling between the mitochondria and the ER. Download PDF transcript Key words: calcium, cAMP, mitochondria, endoplamic reticulum, calcium indicators

    Shedding light on the action potential: Brian Salzberg

    Play Episode Listen Later Oct 27, 2014


    A conversation with Brian Salzberg on using optical methods to measure membrane voltage, calcium, and neuropeptide secretion. Download PDF transcript Key Words: Potentiometric dyes; voltage-sensitive dyes;  arsenazo III, merocyanine-540, posterior pituitary, neurohypophysis, exocytosis, birefringence, secretion, chlorophyll, phototoxicity; squid

    Peering Into the Black Box: Bertil Hille

    Play Episode Listen Later Sep 29, 2014


    A conversation with Bertil Hille, who has devoted many years to investigating ion channel regulation, and permeability mechanisms. Download PDF Transcript Key Words:  Ion channel, permeability, frog, nerve, muscle, GPCRs, local anesthetics

    Taking a thermodynamic approach: Baron Chanda

    Play Episode Listen Later Jul 28, 2014


    A conversation with Baron Chanda, winner of the 2013 Paul F. Cranefield Award Download PDF transcript Key Words:  Ion channel, gating, voltage-clamp fluorimetry, thermodynamics, allosteric linkage

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