Podcasts about Physiology

Science of the function of living systems

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Best podcasts about Physiology

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Latest podcast episodes about Physiology

Barbell Shrugged
The Science of Sleep and Recovery w/ Dr. Allison Brager, Anders Varner, Travis Mash and Doug Larson #821

Barbell Shrugged

Play Episode Listen Later Oct 29, 2025 49:44


In this episode, neuroscientist and U.S. Army sleep expert Dr. Allison Brager joins Anders Varner, Doug Larson, and Travis Mash to explore the real science behind sleep, recovery, and wearable technology. They discuss which devices actually deliver useful data, such as the Oura Ring for sleep tracking and Garmin for cardiovascular measurements, and why being consistent with one tool is more important than chasing perfect accuracy. Dr. Brager explains how wearables are now being used in place of sleep labs in both clinical and military settings to help athletes and operators make better recovery decisions. The conversation dives into practical ways to improve sleep and recovery for anyone pushing performance limits. Dr. Brager describes how sleep apnea can affect even lean, muscular athletes, with studies showing that more than half of Division I football players meet criteria for sleep apnea or insomnia. Just three nights of only five hours of sleep can cut testosterone levels in half. The group also discusses how vagus nerve stimulation, infrared light therapy, and temperature-controlled mattresses such as Eight Sleep can help the body relax, lower stress, and improve sleep quality, especially when used before bed or after long travel. They close by breaking down real-world strategies for recovery and training. Short 20- to 30-minute naps during the afternoon improve alertness, and caffeine can be used strategically during travel to reduce fatigue. Training is most effective when aligned with the body's circadian rhythm, with evening workouts often producing better strength results, while morning training can work after a few months of adjustment. Whether you are a soldier, athlete, or business leader, this episode is about using data, structure, and recovery habits to perform better and stay healthy over the long term. Outside of the laboratory, Allison was a two-time CrossFit Games (team) athlete, a two-time CrossFit Regionals (individual) athlete, and a four-year varsity NCAA Division I athlete in track and field. Dr. Brager has an Sc.B. in Psychology from Brown University and a Ph.D. in Physiology from Kent State University Work With Us: Arétē by RAPID Health Optimization Links: Dr. Allison Brager on Instagram Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram

That Was Pretty Scary
TWPS Listener Pick: Hell House LLC

That Was Pretty Scary

Play Episode Listen Later Oct 29, 2025 68:50


In this episode of 'That Was Pretty Scary,' Jon dives deep into the unsettling brilliance of 'Hell House LLC.' Released in 2015, this found footage horror has made waves with its hyperrealistic approach, reflecting the enterprise culture and media obsession of its time. Jon dissects the film's craft, likening its relatable scare tactics to real life experiences. With shoutouts to his listeners and fellow horror movie enthusiasts, Jon also shares personal insights on vulnerability, grief, and the psychology of fear. Tune in for a detailed breakdown of this low budget yet highly effective horror gem, and don't miss the epilogue where Jon and Alexis brainstorm future projects and address listener feedback.00:00 Introduction to Found Footage Horror01:10 Listener Picks and Personal Reflections06:45 Hell House LLC Overview07:28 The Making of Hell House LLC11:41 2015: A Year in Context22:14 Plot Breakdown and Analysis35:24 The Psychology of Found Footage Horror39:02 The Physiology of Fear in Horror Films39:18 Realism in Horror: The Mundane and the Terrifying40:42 Weaponizing Subtle Visual Disturbances43:44 The Craftsmanship Behind Found Footage Films45:38 The Business of Horror: LLC and Its Implications50:58 The Moral Undertones and Micro-Budget Realism54:39 Epilogue: Reflections and Future Projects Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The PBSCCS Podcast
Episode 217: 217. Interview with Grace Cullen (Part Two)

The PBSCCS Podcast

Play Episode Listen Later Oct 29, 2025 28:52


Grace is a Minor League Strength & Conditioning Coach with the Tampa Bay Rays, where she works to support athlete performance and development throughout the organization. Before joining the Rays, she served as an Assistant Strength & Conditioning Coach at Queens University, working with baseball, men's and women's soccer, and men's tennis. Grace has also spent time in professional baseball with the St. Louis Cardinals as a Player Development Strength & Conditioning Coach and previously interned with the Cleveland Guardians. She holds a master's degree in Applied Kinesiology and Physiology from the University of Florida, and a bachelor's degree in Exercise Science with a minor in Sports Psychology from the University of Evansville.Topics covered in this episode:-Working in the college setting vs. professional baseball-Advice for others and finding success-Continuing education resourcesQuotes:-"I think this year has really solidified that I want to be in pro ball" (4:33)-"I think you should definitely experience both of them. For me, I'm obviously really glad that I experienced and went and worked in the college setting. It makes me appreciate being where I'm at a lot more" (10:36)-"Every day I try and just be really appreciative of the people I get to work with, the athletes I get to work with, and the experience I get to have because it's a really cool job that we have" (23:42)If you would like to learn more from Grace, you can follow her on social media:Instagram:@coachgracecullen

Rhythm, Routine and Reverence
How to Create + Nurture a Plant-Forward Family Culture

Rhythm, Routine and Reverence

Play Episode Listen Later Oct 29, 2025 52:00


Welcome to Rhythm, Routine, and Reverence! In this episode, I sit down with Hannah Van Ark. Hannah is a dietitian, mom of two little ones, and former clinical nutrition researcher on a mission to help other moms feel energized, well-fed, and confident in feeding themselves and their families with a plant-forward lifestyle. She holds degrees in Physiology and Neuroscience from the University of Colorado at Boulder, and a Master's in Food Science and Human Nutrition from Colorado State University. She's also a Registered Dietitian Nutritionist with over six years of experience in clinical nutrition research, where she focused on how food can impact heart health and longevity. These days, Hannah specializes in helping families create realistic, flexible mealtime routines, but with a particular focus on helping mom prioritize THEIR needs and health goals with a plant-forward lifestyle. She lives in Colorado, USA with her husband and two kids.Together we talk about building a plant-forward family culture (not a vegan one) — one rooted in nourishment, connection, and ease. From picky eaters to meal planning, Hannah shares her research-based insights on helping families eat more plants without pressure.Resources & Links* FREE: The Busy Mom's 15-minute Plant Powered Meal Plan: helping families plan a weeks' worth of plant-forward meals in 15 minutes flat (with a sample plan).* FREE: The Plant-Powered Staples Shopping List, a guide that gives you my personal list of pantry, fridge, and freezer staples that make plant-forward eating simple, flexible, and stress-free (+12 easy recipes)* Application for Plant Powered Mom Bootcamp (doors open January 2026)* 1:1 Coaching with Hannah* Hannah's website with recipes, blog posts and more free resources* Hannah's Instagram account: @plant.forward.familiesAt the end of the call Hannah mentions journaling as a rhythm and ritual that is supporting her right now. If you're looking for a format to nurture your own journaling practice check out my own GOLDENTIME Journal. It has just a few prompts for morning and evening. Use code PODCAST15 for 15% off.Right now if you screenshot the podcast episode and tag me in your IG stories you can go into the draw to win a free GOLDENTIME journal this month. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit meaganrosewilson.substack.com/subscribe

The Fitness Movement: Training | Programming | Competing
Kyle Ruth on Respiratory Physiology with Practical Training Applications [Ep.205]

The Fitness Movement: Training | Programming | Competing

Play Episode Listen Later Oct 28, 2025 34:40


Kyle & Ben discuss ways to progress athletes towards optimal breathing, from expanding tidal volume (depth of breaths) to maximizing respiratory frequency (breath rate).» Respiratory Roundtable [Ep.191]: https://www.youtube.com/watch?v=KMt5Hjf7zjY&t» Breathe Way Better with Kyle Ruth: https://www.youtube.com/watch?v=uhr1u23gw20&t» Watch on YouTube: https://youtu.be/f5BSJM2TY4Q» View All Episodes: https://zoarfitness.com/podcast/» Hire a Coach: https://www.zoarfitness.com/coach/» Shop Programs: https://www.zoarfitness.com/product-category/downloads/» Follow ZOAR Fitness on Instagram: https://www.instagram.com/zoarfitness/Support the show

Grow Yourself Up
Ep 147: Your Body Really Does Remember and Shifting Patterns with Dr Kathrin Stauffer (Re-release)

Grow Yourself Up

Play Episode Listen Later Oct 28, 2025 55:10


In this episode Cath was joined by Dr Kathrin Stauffer. They chatted about how the body remembers in multiple ways and how not getting what we need in childhood impacts multiple systems in our bodies (not just the nervous system). When we are on a healing journey the expression of sadness and grieving are an important part of this journey. However, it may be that we are blocked from crying by our defences. We dived into this and talked about food, body shape, body psychotherapy, the the function of comfort eating, shame and much more. Kathrin Stauffer PhD, UKCP Registered Body Psychotherapist, is the author of ‘Emotional Neglect and the Adult in Therapy: Lifelong Consequences to a Lack of Early Attunement' (W.W. Norton 2020).Kathrin was born and educated in Switzerland. Originally a research biochemist, she retrained at the Chiron Centre for Body Psychotherapy. She lives in Cambridge in the UK and works in private practice as a body and humanistic psychotherapist, EMDR practitioner, trainer and supervisor. She previously wrote ‘Anatomy & Physiology for Psychotherapists: connecting Body & Soul' (W.W. Norton 2010). Currently she is the President of the European Association for Body Psychotherapy EABP.You can contact her via her website which is www.stauffer.co.uk.If you're enjoying this podcast. Please leave a review and rate the podcast, this really helps others to find it.To sign up for the journal prompts and Nurture.Heal.Grow (on Substack) please head to www.cathcounihan.com or @cathcounihan on Instagram. Follow Cath on social media here:Instagram: @cathcounihanSubstack: Nurture.Heal.GrowFacebook: Cath Counihan Hosted on Acast. See acast.com/privacy for more information.

Iron Sharpens Iron Radio with Chris Arnzen
October 24, 2025 Show with Christine Schwan on “Holy Yoga???-Now There’s A Stretch!”

Iron Sharpens Iron Radio with Chris Arnzen

Play Episode Listen Later Oct 27, 2025 119:53


October 24, 2025 Christine Schwan,a former Yoga instructor (2008-16)& former Adjunct Professor of Ana-tomy & Physiology (2006-21) current-ly serving as Executive Assistant tothe Elders @ Apologia Church inMesa, AZ, who will address: “HOLY YOGA???—NOW THERE'sA STRETCH!!!: A WARNING to ALLCHRISTIANS ABOUT the INSEPARA-BLE LINKS BETWEEN YOGA & theOCCULT, PAGANISM & SATANISM” Subscribe: Listen:

Pseudocast
Pseudocast #735 – Klasifikácia obezity, Nobelova cena za medicínu

Pseudocast

Play Episode Listen Later Oct 26, 2025 24:18


V tejto časti budeme hovoriť o nových možných kritériách, podľa ktorých klasifikovať obezitu a o Nobelovej cene za medicínu za rok 2025. Zdroje Slovakia needs urgent new obesity management interventions 70% of US May Be Classed as Obese Under New Measures Implications of a New Obesity Definition Among the All of Us Cohort Nobel Prize in Physiology or Medicine 2025 Image by Michal Jarmoluk from Pixabay

Touching Base
Artificial Intelligence in the Emerald City and Targeting Colon Cancer Stem Cells 

Touching Base

Play Episode Listen Later Oct 24, 2025 24:28


We are gearing up for our annual AI in Drug Discovery summit in a few days. So, for this episode, we focused on some recent AI news coverage. First, GEN senior editor Fay Lin, PhD, visited Seattle recently for some AI-focused meetings. She discusses her experiences in the Emerald City including an exclusive in-person interview with Nobel laureate, David Baker, PhD, on what's real and what's hype when it comes to using AI to design proteins de novo.  Then we discuss new research from University of California, San Diego, that used machine learning to identify networks of genes that could be targeted to reprogram cancer stem cells. We also go over some early studies that point to a possible drug candidate for colon cancer.     Join GEN editors Corinna Singleman, PhD, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.  Listed below are links to the GEN stories referenced in this episode of Touching Base:    Brunkow, Ramsdell, Sakaguchi Win Nobel Prize in Physiology or Medicine for Peripheral Immune Tolerance  Uduak Thomas, GEN, October 6, 2025    AI in Protein Design: Hype vs. Reality Explained by David Baker  By Fay Lin, PhD, GEN, October 20, 2025     Nobel Anniversary: David Baker Keynotes STEM Fundraiser by ARCS Foundation Seattle  By Fay Lin, PhD, GEN, October 14, 2025      AI Treatment Reprograms and Triggers Cancer Stem Cells to Self-Destruct  GEN, October 20, 2025      The State of AI in Drug Discovery Registration    Touching Base Podcast  Hosted by Corinna Singleman, PhD  Behind the Breakthroughs  Hosted by Jonathan D. Grinstein, PhD Hosted on Acast. See acast.com/privacy for more information.

WHOOP Podcast
How To Manage Anxiety with Dr. Martha Beck

WHOOP Podcast

Play Episode Listen Later Oct 22, 2025 64:19


This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist Dr. Kristen Holmes sits down with Dr. Martha Beck, world-renowned sociologist, bestselling author, and life coach, to explore what it means to live in alignment with your true self.Dr. Beck shares what her journey from academia at Harvard to becoming one of the world's most sought-after life coaches taught her about life's purpose. Together, Dr. Beck and Dr. Holmes discuss how living out of alignment can lead to physical and emotional distress, why the body often knows the truth before the mind, and how reconnecting with your inner self can restore clarity and fulfillment.Dr. Beck's wisdom will leave you rethinking success, redefining happiness, and inspired to create a life that feels truly your own. Get Off The WHOOP Advanced Labs Waitlist: The first 100 members to tap this link will unlock early access to WHOOP Advanced Labs.**Open the link on the same device as your WHOOP app.(00:48) Dr. Martha Beck: Background in Sociology and the Meaning of Life(03:03) Dr. Beck's Pivot from Sociologist to Life Coach(05:19) The Need to Drop Illusions: How To Overcome Limitations(08:26) WHOOP Podcast Rapid Fire Questions(09:24) The Physiology of Integrity: Accessing Your True Self(16:06) Signs That You Are Ignoring Your True Self(20:03) How The Loss of Integrity Fuels Addiction(23:37) How to Find Your Life Purpose(25:49) Where To Start: Find Your Truth and Live Your Best Life(33:58) High Achievers: How To Set Healthy Goals(36:37) Raising Future Generations To Be In Line with Their Passions(38:41) The Decision Matrix: Making Decisions That Align With Your True-Self(41:42) Gaining Control of Your Fears and Anxiety(45:47) Importance of Solitude and Self-Awareness in Finding Your Truth(49:13) Finding Solitude in a Technologically Connected World(58:16) Understanding Data and Your Body's Signals For Your Mental HealthFollow Dr. Martha Beck:InstagramFacebookYouTubeTiktokSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

The Postpartum Circle
The Invisible Mental Load - Why Mothers Are Breaking Down EP 238

The Postpartum Circle

Play Episode Listen Later Oct 21, 2025 25:39 Transcription Available


Send us a textYour postpartum clients aren't just "busy"—they're breaking down. Here's the truth your assessments are missing: The invisible mental load is a chronic state of cognitive overload that's hijacking her body. This isn't a failure of willpower; it's a physiological response to chronic stress that causes everything from unexplained anxiety and low milk supply to pelvic pain and insomnia. Maranda reveals how this unacknowledged cognitive burden triggers the HPA axis, shuts down nervous system regulation, and creates a cascade of physical symptoms. Every postpartum provider—from lactation consultants to functional health experts—must recognize this root cause. Stop treating the symptoms (the fatigue, the rage, the anxiety) and start addressing the overload. Learn the red flags and the Postpartum Restoration Method framework to deliver the lasting solutions your clients desperately need.Check out the episode on the blog HERE: https://postpartumu.com/podcast/the-invisible-mental-load-why-mothers-are-breaking-down-ep-238/Key time stamps: 1:03 -  Defining The Invisible Mental Load & The Shocking Case of Low Milk Supply3:33 - The Physiology of Cognitive Overload: HPA Axis and Systemic Effects6:53 - Clinical Patterns Providers Miss: The Hyper-Vigilant Manager, Overwhelmed Perfectionist, and Depleted Default Parent9:37 - Pelvic Floor Tension & The Bonding "Disconnection"22:15 - The Red Flags and "Better Questions" for Assessment NEXT STEPS:

Nutritional Revolution Podcast
16,000 Calories Later: The Science & Physiology of Ultra Endurance with Dr. Andrew Creer

Nutritional Revolution Podcast

Play Episode Listen Later Oct 21, 2025 64:34


Send us a textIn episode #157 we talk with researcher Dr. Andrew Creer about:Research on energy expenditure in ultra marathons, as looked at in his recently published research, "Total Energy Expenditure and Intake During a 161-km Mountain Ultramarathon" https://journals.humankinetics.com/view/journals/ijspp/20/6/article-p869.xmlNutritional strategies for optimal performance and recoveryUnderstanding the physiological challenges faced by ultra marathon runners.The critical role of post-race recovery in maintaining athlete health.Future research directions and the evolving science of ultra endurance.Andrew Creer, PhD is a professor and department chair of Exercise Science & Outdoor Recreation at Utah Valley University. His main research interests involve endurance physiology and applied human performance. He has been involved with a number of field studies investigating ultra-endurance physiology and energy expenditure in a variety of locations, including Utah, Oregon, Arizona, France, and Spain.  Dr. Creer also works closely with several athletic teams at UVU monitoring aspects such as body composition and performance nutrition, and is a performance nutrition consultant for several prominent members of the local running community.Connect with Dr. Andrew Creer:IG: https://www.instagram.com/uvu_docWeb: https://www.uvu.edu/college-of-science/exercise-science/about/index.htmlResearchGate: https://www.researchgate.net/profile/Andrew-Creer-2Mentioned:Total Energy Expenditure and Intake During a 161-km Mountain Ultramarathon: https://journals.humankinetics.com/view/journals/ijspp/20/6/article-p869.xmlThe Compelling Link Between Physical Activity and the Body's Defense System, David C, Nieman & Laurel M. Wentz: https://pubmed.ncbi.nlm.nih.gov/31193280/Ultra-endurance Athletes and the Metabolic Ceiling, Andrew Best et. al: https://www.cell.com/current-biology/fulltext/S0960-9822(25)01129-7The Western States 100-Mile Endurance Run: Participation and Performance Trends: https://pmc.ncbi.nlm.nih.gov/articles/PMC2809551/Competition Nutrition Practices of Elite Ultramarathon Runners: https://pubmed.ncbi.nlm.nih.gov/260MORE NR New customers save 10% off all products on our website with the code NEWPOD10 If you would like to work with our practitioners, click here: https://nutritional-revolution.com/work-with-us/ Save 50% off your 1st Trifecta Nutrition order with code NR50: https://trifectanutrition.llbyf9.net/qnNk05 Save 20% on all supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off right away with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

Pivot The Path
EP 97: Use It or Lose It — The Physiology Behind Your Golf Game

Pivot The Path

Play Episode Listen Later Oct 21, 2025 26:30


What are the parallels between an NFL player and your average golfer? More than you might think. Recently, NFL legend Jason Kelce asked himself a simple question: Could I still complete an NFL workout now that I'm retired? The result was a humbling reminder that even elite athletes lose strength, speed and capability if they stop training for the demands of their sport.And the truth is, the same principle applies to you and your golf game. If you want to generate rotational power, control the clubface, maintain mobility and swing consistently, you have to train those physical capabilities with purpose. Your body adapts to what you do most often — stop challenging it, and it stops being ready to perform.“Use it or lose it” isn't just a phrase — it's physiology. And if you're serious about improving, staying strong and playing your best golf for years to come, that commitment to consistent movement, strength, and intention is how you truly Own Your SSWING.Mentions in this episode:Can Jason Kelce still do an NFL workoutScott Young with the NYU Golf Lab on ABC NewsShop SSWING Swag 

Fitness e dintorni
Allenamento della forza e invecchiamento neuromuscolare

Fitness e dintorni

Play Episode Listen Later Oct 21, 2025 3:31


In un'ampia e dettagliata rassegna pubblicata sulla rivista Physiology, un gruppo di ricercatori statunitensi ha analizzato in modo esaustivo gli effetti dell'allenamento contro resistenza sull'invecchiamento neuromuscolare, approfondendo non solo i benefici macroscopici in termini di forza e massa muscolare, ma anche i meccanismi cellulari e molecolari sottesi alle risposte adattative nell'anziano.

The Progression Health Podcast
Episode 86 The Science behind Elite Endurance in half and Marathon Running Success with Philip Batterson

The Progression Health Podcast

Play Episode Listen Later Oct 21, 2025 53:57


In this episode, Ross Dempsey talks with Philip Batterson about the science behind elite endurance in half marathon and marathon success. Philip shares insights into the physiology, psychology, and training strategies that allow athletes to push the limits of human performance.From oxygen uptake and VO₂ max, to fueling strategies, mindset, and the role of AI in modern training, this conversation blends science with practical advice for runners at every level. Whether you're preparing for your first half marathon or chasing a personal best in the full marathon, this episode will help you understand what truly drives elite endurance.

Quirks and Quarks Complete Show from CBC Radio
Moose are hot and bothered, and more...

Quirks and Quarks Complete Show from CBC Radio

Play Episode Listen Later Oct 17, 2025 54:09


Nobel in Medicine for a leash on our immune systemOur immune system has enormous power to defend us against the wide range of pathogens and invaders that nature sends at us. But it's a double-edged sword, and can target its powerful weapons against us as well. This year's Nobel prize in Medicine or Physiology went to a group who discovered a critical mechanism that keeps the immune system in check, under normal circumstances, giving them new insights into the diseases that occur when it goes wrong.Yogurt with a creepy-crawly secret ingredientA team of researchers has duplicated an ancient recipe for yogurt that uses a unique ingredient to initiate fermentation: ants. They added squished ants to fresh milk, buried it in an anthill to incubate it, and enjoyed zesty yogurt soon after. A microbiological analysis showed that the ants contributed a bacteria to the yogurt that is also present in sourdough starter.An ancestor of the largest dinosaurs was a dog-sized bipedResearchers have discovered a 230 million year old fossil high in the Andes of Argentina that is the precursor to the giant, long-necked sauropod dinosaurs like the iconic brontosaurus. This animal, however, is a two-legged herbivore that likely weighed less than 20 kilograms.Nobel in Physics for making particles ghostlyQuantum tunneling is a strange phenomenon in which subatomic particles can pass through apparently impenetrable objects like magic. This year's Nobel prize in physics was awarded to a team that discovered that this strange quantum phenomena can happen on larger scales too, and this has been exploited in all sorts of modern technology, including quantum computers.Neanderthals systematically rendered fat from animal bonesScientists think that the fragmented bones of hundreds of animals discovered at a neanderthal site in Germany represent the remains of a large-scale processing site where they extracted nutritious and useful fat. This could be used for a range of things, from skin protection to preserving meat similar to pemmican.Moose are hot. Are they bothered?During the fall rut moose, particularly the males, are very active searching for mates and competing with rivals. This activity generates a large amount of heat, which could be a problem as moose don't sweat. Scientists are investigating if, in a warmer climate, this might be interfering with their reproductive success.

Ask Doctor Dawn
Nobel Prize for T Regulatory Cell Discovery, Chronic Pain Psychology, and Vaccine Dementia Protection

Ask Doctor Dawn

Play Episode Listen Later Oct 17, 2025 54:18


Broadcast from KSQD, Santa Cruz on 10-16-2025: Dr. Dawn explains the 2025 Nobel Prize in Physiology awarded to Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell for discovering T regulatory cells. Previously, medical teaching held that the thymus only eliminated self-attacking T cells, but Sakaguchi found that removing the thymus from newborn mice caused autoimmune disease, suggesting protective regulatory cells existed. He identified CD4+CD25+ cells that suppress inflammation and can convert other T cells. Brunkow and Ramsdell discovered the FOXP3 gene that controls these cells, linking mutations to severe autoimmune diseases like IPEX syndrome. Tissue-specific Tregs regulate metabolism in fat, maintain gut microbiome tolerance, promote wound healing in skin, and control muscle regeneration. Therapeutic applications include stopping type 1 diabetes, preventing organ rejection, and treating multiple sclerosis. An emailer asks about a study linking soft drinks to depression through gut bacteria changes. Dr. Dawn critiques the cohort association study for establishing only correlation, not causation, with a weak risk ratio of 1.1 representing just 10% increased association. She explains that bacteria can influence food cravings, making it unclear whether sodas change bacteria levels or bacteria drive soda consumption. Without Koch's postulates—isolating bacteria, growing them, and reproducing disease—the causal direction remains uncertain despite statistical significance. Dr. Dawn reads David Whyte's essay on injury as invitation to transformation, exploring how pain reveals vulnerability, changes identity, requires patience, and teaches compassion. She notes this perspective may come easier to men who reach midlife believing they control their bodies, while menstruation disabuses women of that illusion earlier. As a physician, she emphasizes the ego crisis when people transition from healthy to "person with disease," requiring identity restructuring that can shake foundations but also mature and strengthen individuals. A caller responds enthusiastically to the injury essay, citing quotes from André Gide, James Hillman, and Norman O. Brown about how illness opens doors to reality closed to healthy mindedness, how the soul sees through affliction, and how vulnerability is inherent to being human. Dr. Dawn agrees that many religions embrace wounds as paths to spiritual enlightenment and commits to deeper reflection on suffering's role in the human condition. Dr. Dawn discusses cognitive functional therapy for chronic back pain, describing firefighter Joe Lawrence who believed his spine was irreparably damaged until physical therapist Peter O'Sullivan challenged those beliefs. The therapy addresses psychological aspects by teaching that backs need movement, not protection, and that tensing muscles worsens pain. The three-step approach examines pain origins including emotional context, gradually reintroduces avoided activities while learning relaxation, and establishes healthy sleep and exercise routines. GLP-1 drug prices have dropped dramatically to $499 monthly at Costco due to compounding pharmacy competition. Dr. Dawn urges immunizations, noting studies show shingles vaccination reduces dementia risk by 20% over seven years, possibly by generating T regulatory cells that reduce brain inflammation. Natural experiments in England where vaccine rollout occurred at different times in different regions provided strong evidence. She explains that chickenpox vaccination in childhood prevents both chickenpox and future shingles. Even tetanus shots appear to lower dementia risk, suggesting vaccines activate immune responses that reduce chronic inflammation. She concludes with practical advice to reduce microplastic exposure by avoiding plastic cups and containers, especially with heat. Eight-year-old coffee makers contain twice the microplastics of six-month-old machines due to deterioration. She recommends ceramic cups, glass or metal kettles, removing food from plastic before cooking, and washing polyester clothing on low heat to minimize microplastic generation.

The MindBodyBrain Project
Embracing Stress: Understanding Its Role and Building Resilience – Part Two

The MindBodyBrain Project

Play Episode Listen Later Oct 17, 2025 36:13 Transcription Available


In Part Two of my conversation, with Professor Jeremy Jamieson we explore the fascinating dynamics of stress and resilience, specifically emphasising the roles parents can play in helping their children grow up resilient and strong. We discuss the importance of fostering a positive relationship with stress and understanding the biological and psychological factors that play into this often misunderstood aspect of life. What You'll Learn: Understanding Stress: Discover how stress functions as a natural response and how it can be beneficial rather than detrimental. Challenge vs. Threat Mindsets: Learn why perceiving stress as a challenge rather than a threat can completely alter the physiological response. Parenting Techniques for Resilience: Get insights into how parents can prepare their children for life's challenges by encouraging them to tackle difficult situations head-on. Key Takeaways: Stress is Not the Enemy: Stress, when approached properly, can be a tool for growth and resilience rather than a harmful force. It’s about perception and management. Parents as Guides, Not Rescuers: Instead of removing obstacles for your children, teach them to navigate these challenges. Encourage them to be proactive and resilient. Develop a Toolbox for Stress Management: Different situations require different responses—having a flexible approach to managing stress is crucial. The Role of Physiology in Stress: Understanding and managing physiological responses through activities such as regular exercise, sleep hygiene, and possibly cold immersion sessions can help in dealing with stress effectively. Importance of a Healthy Lifestyle: Adequate sleep, nutrition, and limiting technology use can have profound impacts on mental health, influencing stress levels and resilience capacity. Resources Explore more about the extraordinary work at Mount Hope Family Center, which is helping children overcome trauma through innovative research on biological embedding. Connect with Professor Jeremy Jamieson on LinkedIn University of Rochester - Professor Jeremy Jamieson Social Stress Lab Support the Podcast If you found this discussion insightful, consider subscribing, rating, and leaving a review of our podcast. Your support allows us to continue sharing impactful conversations that inspire change. Share this episode with someone who might benefit from understanding stress as a tool for growth—knowledge like this can truly make a difference in navigating life's challenges. 01:08 Building Resilience in Children 02:12 The Role of Social Connections in Stress Management 04:15 Understanding Stress Responses 06:20 Boosting Stress Capacity 07:44 The Impact of Educational Systems on Stress 09:33 Physiological Approaches to Stress Management 14:36 The Role of Virtual Reality in Stress Management 17:28 Tailoring Stress Management Techniques 18:31 Future Directions in Social Media and AI Interventions 19:10 Challenges and Promising Interventions 20:02 The Role of AI in Stress Management 21:57 Parental Advice for Raising Resilient Kids 28:59 The Importance of Sleep and Diet See omnystudio.com/listener for privacy information.

Think Twice Podcast
48: Interviewing a 1906 Nobel Prize Winner

Think Twice Podcast

Play Episode Listen Later Oct 17, 2025 32:30


Santiago Ramón y Cajal, awarded the 1906 Nobel Prize in Physiology or Medicine, is often called the “father of modern neuroscience.” Using only a microscope and his extraordinary artistic skills, he revealed that the brain is made up of individual neurons that communicate across tiny gaps. This discovery, known as the “neuron doctrine,” transformed how we understand the brain and laid the foundation for all of modern neuroscience. Cajal's detailed drawings of a wide variety of neurons and neuroanatomical circuits are still admired today, both as scientific breakthroughs and works of art. Join us as we talk with an AI interpretation of Santiago Ramón y Cajal about his scientific findings, his disagreements with other neuroscientists and his advice to junior scientists. This episode is sponsored by the Connected Minds program. Connected Minds, funded by the Canadian First Research Excellence Fund, is a 7-year collaborative program between York University and Queen's University that focuses on interdisciplinary, ethical, and socially responsible research and technology development. The program offers funding for trainees, researchers, and artists. To learn more and get involved, visit the Connected Minds website. Website: https://www.yorku.ca/research/connected-minds/a Authors: Eve Racette, Golnar Taheri Email: thinktwicepodcast@outlook.com Instagram: @thinktwice_podcast LinkedIN: Think Twice Podcast Patreon: https://www.patreon.com/ThinkTwicePodcast Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user's own risk and is not intended to replace professional healthcare services.

The Strength Running Podcast
How to Build Physiological Resilience in the Marathon with Coach John Davis, PhD

The Strength Running Podcast

Play Episode Listen Later Oct 16, 2025 69:05


John Davis holds a PhD in Biomechanics, coaches elite marathoners, and is the author of Modern Training and Physiology for Middle and Long Distance Runners. His newest book is a masterclass on marathon preparation: Marathon Excellence for Everyone. It includes new research on training theory, elite-level training plans, and guidance for every type of aspiring marathoner. Today, we discuss physiological resilience:  How physiological resilience is like the 4th metric of performance How to build this skill safely Example workouts for beginner to advanced runners The role of "depletion workouts" in physiological resilience What actually causes the "marathon fade" at the end of 26.2 miles Learn more about John's new book on the Marathon Excellence website or follow him on IG here. You can browse Strength Running's marathon plans here. Thank you Previnex! After resisting most supplements for the better part of my life, I'm cautiously changing my tune. I'm now a Masters runner and in my personal life, I'm optimizing for longevity. I want to be my healthiest self for as long as possible and I'm excited to partner with Previnex to make that happen. Previnex uses the most bioavailable, clinically tested ingredients, the optimal form and dose of each ingredient, pharmaceutical grade manufacturing, testing of raw ingredients and finished products. For every purchase you make, they also donate vitamins to kids in need. Their new Muscle Health Plus is something I'm now taking. Turning 40 – and having a thin frame – has made me realize that I need to prioritize lean muscle mass to stay healthy and age well. Muscle Health Plus has creatine, essential and branched chain amino acids, and it's designed in a way to maximize protein synthesis and the absorption of amino acids. Muscle Health Plus will help you prevent muscle damage, which is particularly important for aging runners who want to protect themselves from muscle loss and recover faster after hard workouts. As is true for all of their products, Previnex adheres to the highest of standards: their ingredients are clinically proven to do what they say they're going to do. They're now offering international shipping so if you live in the UK, Canada, Australia, or anywhere around the world, you can try Previnex as well. Previnex offers a 30-day money back guarantee. If you don't feel the benefits of their product, you get your money back no questions asked. With their focus on quality and customer satisfaction, I hope you'll try it! Use code jason15 for 15% off your first order at Previnex! Thank you LMNT! A big thanks to LMNT for their support of this episode! They make electrolyte drinks for athletes and low-carb folks with no sugar, artificial ingredients, or colors. They are offering a free gift with your purchase at LMNT. And this does NOT have to be your first purchase. You'll get a sample pack with every flavor so you can try them all before deciding what you like best. And BIG news! Their newest flavor is now permanently available : LEMONADE SALT! LMNT's products have some of the highest sodium concentrations that you can find. Anybody who runs a lot knows that sodium, as well as other electrolytes like magnesium and potassium, are essential to our performance and how we feel throughout the day. If you're not familiar, LMNT is my favorite way to hydrate. They make electrolytes for athletes and low-carb folks with no Sugar, artificial ingredients, or colors. I'm now in the habit of giving away boxes of LMNT at group runs around Denver and Boulder and everyone loves this stuff. Boost your performance and your recovery with LMNT. They're the exclusive hydration partner to Team USA Weightlifting and quite a few professional baseball, hockey, and basketball teams are on regular subscriptions. So check out LMNT to get a free sampler pack and get your hydration optimized for the upcoming season.

The Health Advocates
S8, Ep 35- How Nobel-Winning Science is Bringing Hope to People With Autoimmune Diseases

The Health Advocates

Play Episode Listen Later Oct 16, 2025 8:58


The 2025 Nobel Prize in Physiology or Medicine recognized groundbreaking advances in understanding immune regulation — but what do they mean for people living with autoimmune disease? In this episode, Dr. Shilpa Venkatachalam, Chief Patient-Centered Research and Ethical Oversight Officer at GHLF, joins Steven to explore how our immune system knows when to act — and when to stop. Shilpa explains the importance of these discoveries, why immune “brakes” matter in autoimmune conditions like lupus or rheumatoid arthritis, and how research breakthroughs can lead to better treatments. She also shares why patients are key partners in turning lab science into real-world therapies. Tune in to learn how Nobel-winning science could help unlock better care for autoimmune disease. To read the full article — “How a Nobel Prize Discovery Gives New Hope for Calming the Immune System in Autoimmune Diseases” — visit: https://creakyjoints.org/research/research-immune-nobel-prize-autoimmune/Contact Our Host Steven Newmark, Chief of Policy at GHLF: snewmark@ghlf.org A podcast episode produced by Ben Blanc, Director, Digital Production and Engagement at GHLF. We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Listen to all episodes of The Health Advocates on our website (https://ghlf.org/the-health-advocates) or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

The PBSCCS Podcast
Episode 216: 216. Interview with Grace Cullen (Part One)

The PBSCCS Podcast

Play Episode Listen Later Oct 15, 2025 24:14


Grace is a Minor League Strength & Conditioning Coach with the Tampa Bay Rays, where she works to support athlete performance and development throughout the organization. Before joining the Rays, she served as an Assistant Strength & Conditioning Coach at Queens University, working with baseball, men's and women's soccer, and men's tennis. Grace has also spent time in professional baseball with the St. Louis Cardinals as a Player Development Strength & Conditioning Coach and previously interned with the Cleveland Guardians. She holds a master's degree in Applied Kinesiology and Physiology from the University of Florida, and a bachelor's degree in Exercise Science with a minor in Sports Psychology from the University of Evansville.Topics covered in this episode:-Her best professional baseball story-Being a younger coach in the field-Axial loading for baseball players-Learning how to coach effectively without technology-Working with unfamiliar sports and athletesQuotes:-"Their spine is so mobile and gets put in such crazy positions that I'm not really a huge fan of putting a bunch of weight on their back" (7:28)-"I just think people need to hammer the basics when they're coming up and they're interning" (10:04)-"I think whenever a coach writes a new program they probably modify it like five times" (19:39)If you would like to learn more from Grace, you can follow her on social media:Instagram:@coachgracecullen

Between Two Lips
The Biology of Trauma and How It Can Influence The Pelvic Floor with Dr Amie Apigian

Between Two Lips

Play Episode Listen Later Oct 15, 2025 48:10


Dr. Aimie Apigian, double board-certified physician (Preventive/Addiction Medicine) with master's degrees in biochemistry and public health, revolutionizes trauma healing by revealing how our cells—not just our minds—store trauma. Her book "The Biology of Trauma" (foreword by Gabor Maté) transforms our understanding of how the body experiences and holds trauma. After adopting a child during medical school sparked her journey, she developed an integrative science-based sequence for the healing journey. Through her practitioner training, podcast, YouTube channel, and international speaking, she bridges functional medicine, attachment and trauma therapy, proving that repairing trauma's impact on the mind, body and biology is possible.www.biologyoftrauma.comhttps://www.instagram.com/draimie/?hl=enhttps://www.youtube.com/c/DrAimieApigian_________________________________________________________________________________________Come join me in my Buff Muff community www.buffmuff.comThank you so much for listening! I use fitness and movement to help women prevent and overcome pelvic floor challenges like incontinence and organ prolapse. There is help for women in all life stages! Every Woman Needs A Vagina Coach! Please make sure to LEAVE A REVIEW and SUBSCRIBE to the show for the best fitness and wellness advice south of your belly button. *******************I recommend checking out my comprehensive pelvic health education and fitness programs on my Buff Muff AppYou can also join my next 28 Day Buff Muff Challenge https://www.vaginacoach.com/buffmuffIf you are feeling social you can connect with me… On Facebook https://www.facebook.com/VagCoachOn Instagram https://www.instagram.com/vaginacoach/On Twitter https://twitter.com/VaginaCoachOn The Web www.vaginacoach.comGet your Feel Amazing Vaginal Moisturizer Here

Chasing Clarity: Health & Fitness Podcast
CALVIN SCHELLER: THE PHYSIOLOGY OF APPETITE: HOW HORMONES & FOOD CHOICES DRIVE HUNGER | EP. 184

Chasing Clarity: Health & Fitness Podcast

Play Episode Listen Later Oct 15, 2025 94:35


On this week's episode of the CHASING CLARITY: HEALTH & FITNESS PODCAST, I sat down with Calvin Scheller to break down one of the most misunderstood topics in nutrition: appetite regulation.We explore how your hormones, macronutrient intake, and food choices shape the way you experience hunger and why so many people struggle to feel full, even when they're eating enough.This conversation goes far beyond “just eat less.” It's about understanding the physiological drivers of hunger, how to work with your body instead of against it, and how to improve appetite regulation so you can better manage your energy intake, physique, and long-term results.Whether you're looking to lose fat, trying to build muscle, or simply want to feel more in control of your appetite, this episode is for you.WHAT WE COVER IN THIS EPISODE:WHAT IS APPETITE?WHAT IS LEPTIN & WHAT ROLE DOES IT PLAY IN APPETITE REGULATION?WHAT IS LEPTIN RESISTANCE & HOW DOES IT IMPACT HUNGER SIGNALS?WHAT STRATEGIES IMPROVE LEPTIN SENSITIVITY?WHAT IS INSULIN & HOW DOES IT AFFECT APPETITE & SATIETY?HOW INSULIN SUPPRESSES HUNGER WHAT IS GHRELIN & HOW DOES IT INFLUENCE HUNGER & FOOD-SEEKING BEHAVIOR?WHAT IS CORTISOL & HOW DOES STRESS IMPACT APPETITE REGULATION?HOW DO PROTEIN & AMINO ACIDS IMPACT APPETITE?CLINICAL RESEARCH ON HIGH-PROTEIN DIETS & SATIETYHOW DO GLUCOSE & CARBOHYDRATES IMPACT APPETITE?WHY INSULIN-SPIKING, HIGH-CARB MEALS ARE OFTEN MORE SATIATING THAN HIGH-FAT MEALSWHAT EFFECT DO DIETARY FATS HAVE ON APPETITE & HUNGER?WHY DIETARY FAT IS THE LEAST SATIATING MACRONUTRIENT PER CALORIEWHAT ARE HYPER-PALATABLE FOODS & HOW DO THEY OVERRIDE SATIETY SIGNALS?WHAT THE RESEARCH SHOWS ABOUT ULTRA-PROCESSED FOODS & CALORIE INTAKEThis one's a masterclass in appetite regulation blending deep science with practical takeaways so you can make better nutrition decisions, regulate hunger, and stay on track with your goals.WHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/For Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryEmail: Bdacruzfitness@gmail.comBrandon's Website: https://www.brandondacruzfit.com

Sigma Nutrition Radio
#580: Sodium Bicarbonate for Sports Performance – Prof. Lewis Gough

Sigma Nutrition Radio

Play Episode Listen Later Oct 14, 2025 62:45


Sodium bicarbonate is one of the most consistently supported ergogenic aids in sports nutrition research, yet its underlying mechanisms and real-world applications remain widely misunderstood. More recent developments have focused on how to optimise both the timing and formulation of supplementation. The “individualised ingestion timing” approach has emerged as a practical strategy, recognising that the time-to-peak blood bicarbonate concentration varies considerably between individuals. Similarly, novel formulations are being explored to address issues with gastrointestinal distress and practicality of dosing. These include topical approaches such as sodium bicarbonate lotion, and commercial products like Maurten's “Bicarb System.” In this episode, Prof. Lewis Gough joins to discuss the latest evidence on sodium bicarbonate and performance, its mechanisms, novel delivery systems, and the key directions for future research. Dr. Lewis Gough is Associate Professor in Nutrition and Physiology at Birmingham City University. He is globally recognized for his research on sodium bicarbonate supplementation in sport, and his work spans applied sport and exercise nutrition, exercise metabolism, acid–base balance, and fatigue. Timestamps [03:12] Professor Gough's academic journey [06:29] Mechanisms of sodium bicarbonate and historical perspective on lactate [11:21] Sodium bicarbonate's role in performance [22:45] Individual responses to sodium bicarbonate [26:53] Timing strategies for sodium bicarbonate [32:38] Individualized approach to sodium bicarbonate timing [36:47] Traditional vs. novel delivery methods [44:27] Practical recommendations for athletes [51:18] Future research directions [01:02:08] Key Ideas segment Resources Go to episode page (w/ links to relevant studies) Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course See all of Sigma's "Recommended Resources"

The Ali Damron Show
How to Break the Cycle of Stress by Feeling Safe Instead of Forcing Calm

The Ali Damron Show

Play Episode Listen Later Oct 14, 2025 38:42


Summary In this episode, Ali Damron explores the intricate relationship between stress, repressed emotions, and the nervous system. She discusses how stress manifests in our bodies and minds, the impact of childhood experiences on emotional development, and the importance of radical acceptance in managing anxiety. The conversation emphasizes the need to recognize and process emotions rather than suppress them, highlighting the role of coping mechanisms and the significance of teaching our brains to feel safe. Ali encourages listeners to engage with their emotions and live their lives despite the presence of anxiety and stress. Takeaways Life is inherently stressful, affecting various aspects of our lives. Stress can lead to hormonal imbalances and various health issues. Managing stress is often oversimplified; we need deeper strategies. Repressed emotions can keep us stuck in anxiety. The nervous system interprets suppressed emotions as danger. Childhood experiences shape our emotional responses and coping mechanisms. Coping strategies often involve avoidance behaviors. Radical acceptance helps in acknowledging and processing emotions. Teaching the brain that it is safe to feel is crucial for healing. Engaging with life despite anxiety can promote emotional safety. Sound bites "How do we actually manage stress?" "Your brain and body are one thing." "Radical acceptance is not giving up." Chapters 00:00 Understanding Stress and Repressed Emotions 02:45 The Physiology of Stress and the Nervous System 06:07 Emotional Repression and Its Impact 08:56 The Role of Childhood in Emotional Development 12:13 Coping Mechanisms and Avoidance Strategies 15:02 Radical Acceptance: A Path to Healing 17:48 Teaching the Brain Safety 21:08 Engaging with Emotions and Anxiety 23:54 Rewiring the Brain for Safety 26:36 Summary and Next Steps Ali's Resources:  Calm the Chaos: Practical Tips and Tools for Stopping Anxiety in It's Tracks Course! Consults with Ali  BIOptimizers Magnesium Breakthrough 10% off using code ALIDAMRON10 www.alidamron.com/magnesium Master Your Perimenopause Course + Toolkit "Am I in Perimenopause?" Checklist.  What Hormone is Imbalanced? Quiz! Fullscript (Get 10% off all supplements) "How To Balance Your Hormones For Better Sleep, Mood, Periods and Energy" Free, On Demand Training Website  Ali's Instagram Ali's Facebook Group: Holistic Health with Ali Damron 

Thyroid Answers Podcast
Episode 208: Nitric Oxide - The Molecule That Could Transform Your Thyroid Health

Thyroid Answers Podcast

Play Episode Listen Later Oct 14, 2025 95:56


Episode 208: Nitric Oxide - The Missing Link in Thyroid & Chronic Disease with Dr. Nathan Bryan In this episode, Dr. Eric Balcavage is joined by nitric oxide researcher and author Dr. Nathan Bryan, whose new book The Secret of Nitric Oxide explores why this tiny signaling molecule may be the key to preventing and reversing chronic illness. Together, they dive deep into: What nitric oxide is and why it's foundational for human health. How nitric oxide is made in the body—through both enzymatic and dietary pathways. The connection between nitric oxide, inflammation, oxidative stress, and the Cell Danger Response (CDR). How nitric oxide influences thyroid hormone production, conversion (T4 → T3), and the rise of reverse T3. Why loss of nitric oxide is one of the earliest triggers in chronic disease, including Hashimoto's, cardiovascular disease, Alzheimer's, and more. Common disruptors of nitric oxide production—nutrient deficiencies, environmental toxins, poor lifestyle habits, and even fluoride exposure. Practical steps to restore nitric oxide production naturally for better thyroid, metabolic, and overall health. This is a powerful conversation that reframes nitric oxide not as just a cardiovascular molecule, but as a master regulator of cellular health, energy production, and thyroid physiology.

The Tara Talk
110: Sadie Lincoln: Why “Brave Space” Training Changes Everything

The Tara Talk

Play Episode Listen Later Oct 14, 2025 49:53


Think fitness has to be all-or-nothing? That the only way to see results is to grind harder, sweat more, and push through pain?  If you've ever felt stuck in the shame cycle of workouts that feel like punishment, this episode is going to flip the script.In this episode, I'm joined by Sadie Lincoln, co-founder and CEO of Barre3, to talk about why the fitness industry has sold women on shame and “no pain, no gain,” and how to replace it with a smarter, more sustainable model.We dive into Sadie's comfort → brave → fight framework, the truth about modifications as performance tools, and why short movement snacks throughout the day often beat one big sweat session. Sadie also shares how to tune into your body's sensations to quiet the inner critic, plus her honest take on wearables, recovery, and motivation that actually lasts.If you're ready to shift from grinding harder to working smarter, this episode will show you how to find strength, confidence, and longevity, in and out of the gym.Sadie Lincoln is the co-founder of Barre3, a global fitness company with over 200 studios and a thriving online platform. With more than 17 years of teaching experience, she's redefining what results look like for women by combining strength, cardio, and mindfulness into every class.We Also Discuss:(00:46) Why shame sells in fitness, yet never sticks(11:05) The mindset shift that makes workouts feel empowering, not punishing(20:46) How growth really happens, and why community matters more than willpower(25:33) The industry myth women should finally start questioning(38:22) One simple movement practice that can change your entire day(42:20) Why modifications aren't “less than”, they're the smarter way to train(46:31) Progression vs. perfection: redefining what success actually looks likeThank You to Our Sponsors:Timeline: 20% off of Mitopure Gummies. Just go to timeline.com/TARA, and see what it feels like when your recovery and strength finally click. Check out more from Broads:Website: https://www.broads.app/Instagram: @broads.podcast @broads.appFind more from Sadie Lincoln:Website: https://barre3.comInstagram: @barre3Instagram: @sadielincoln  

Personal Development Unplugged
FMQ 517 How to Really Be Successful

Personal Development Unplugged

Play Episode Listen Later Oct 14, 2025 9:55


How to Really Be Successful Ever heard people bang on about mindset — and thought, “Yeah, but what about the rest of me?” This Five-Minute Quickie goes beyond the buzzword. Because success isn't just in your head — it's in your body too. In this short but mighty episode, we explore: Why mindset alone isn't enough — and what “body-set” really means How to align your physiology and psychology so your goals feel inevitable Simple ways to tap into your “future you” — breathing, posture, tone, gestures — to unlock real, embodied confidence Cloughie breaks it down in his trademark way: fun, grounded, and totally usable. When you bring your body and mind into alignment, you don't have to fake success — you become it. Takeaway: Success is a feeling you live, not just an idea you think. Act, move, and breathe like you've already achieved it — because that's how you'll get there quicker, bigger, and better. Please share and see others grow too: https://personaldevelopmentunplugged.com/fmq-517-how-to-really-be-successful Oh! And there's a video of me recording this too https://youtu.be/NnGVNaRiabI Got feedback, a question, or a win to share? Email: feedback@personaldevelopmentunplugged.com Shine Brightly

The Drug Discovery World Podcast
DDW Highlights: 14 October 2025

The Drug Discovery World Podcast

Play Episode Listen Later Oct 14, 2025 15:34


The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, the Nobel Prize for Physiology or Medicine was awarded to three scientists for their discovery on regulatory T cells. Elsewhere, AI use continues to rise in pharma and biotech, while CAR-T therapy has been used for the first time to treat ulcerative colitis.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Wellness Her Way with Gracie Norton
How Becoming Metabolically Flexible Can Transform Your Health with Dr. Latt Mansor

Wellness Her Way with Gracie Norton

Play Episode Listen Later Oct 13, 2025 51:07


Episode 106: In this episode, I'm joined by Dr. Latt Mansor, a world expert in physiology and metabolism. Dr. Latt Mansor holds a PhD in Physiology, Anatomy and Genetics from the University of Oxford. He is a researcher and expert in human metabolism, to break down what it really means to be metabolically flexible. We dive deep into how insulin resistance develops, what it does to your energy, hormones, and longevity, and how ketones can play a role in supporting your metabolic health.Dr. Latt Mansor simplifies the complex science of fuel switching and how your body moves between burning glucose and fat. He also shares practical ways to build metabolic flexibility through nutrition, movement, and lifestyle shifts.If you've ever felt tired after eating, struggled with cravings, or wondered what ketones actually do in the body, this episode will connect the dots between your metabolism, your energy, and your everyday habits.Save 30% off your first subscription order & receive a free six pack of Ketone-IQ with http://ketone.com/GRACIE CONNECT WITH ME:Cookin Up Wellness Ebook: HERE Nite Nectar Restock: HERE Instagram: @Gracie_NortonWellness Her Way Instagram: HEREProduced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Soundside
What's the difference between a scurfy mouse and a scruffy mouse? A Nobel Prize

Soundside

Play Episode Listen Later Oct 13, 2025 17:10


It’s been quite a week for one Seattle scientist, after getting an unexpected late-night call from a Swedish phone number last week. That call turned out to bring good news: Dr. Mary Brunkow is sharing this year’s Nobel Prize in Physiology or Medicine. She’s being honored for research she did decades ago; work that would eventually loom large in developing ways to treat autoimmune disease and cancer. We’ve asked Dr. Brunkow to reflect a bit on what that work looks like in hindsight, and what it means to share this honor… GUEST: Dr. Mary Brunkow RELATED LINKS: She didn’t believe she won the Nobel — until a photographer showed up at her Seattle door Mary E. Brunkow – Facts – 2025 - NobelPrize.org UW alum awarded Nobel Prize in Medicine – Be Boundless Thank you to the supporters of KUOW, you help make this show possible! If you want to help out, go to kuow.org/donate/soundsidenotes Soundside is a production of KUOW in Seattle, a proud member of the NPR Network.See omnystudio.com/listener for privacy information.

The Doctor Coach Schoolâ„¢ Podcast
The Real Science of Belief: How Coaches Create Results and Movements

The Doctor Coach Schoolâ„¢ Podcast

Play Episode Listen Later Oct 13, 2025 33:41


In this open-house episode, we're diving deep into the science of belief—what it is, what it isn't, and why it's the foundation of every result you want in your coaching business. You'll learn how to stop chasing strategy to compensate for a lack of belief, how to build embodied belief in your body and behavior, and how to move clients into results without codependency. You'll also hear how The Doctor Coach School™ certification operationalizes this science through frameworks, skills labs, and evaluation—and how to apply.What you'll learnBelief ≠ mindset hacks. Why affirmations alone don't rewire the brain—and what embodied belief actually is.Physiology of belief. How belief (and disbelief) are felt in the body and reflected in behavior and results.Strategy needs fuel. Why strategy without belief leads to overwork, convincing energy, and inconsistency.The Pocket of Belief. A practical framework for coaches and clients that turns trust into transformation.From fixing to coaching. How to stop attracting disempowered clients and start partnering with agency.Codependency check. How to identify “I need my client to succeed so I can feel valid” energy—and shift out of it.About The Doctor Coach School™ CertificationPhase 1 (Coaching Self): Pocket of Belief, Belief Flow™, Action-Belief Process™, Safety Formula™—with weekly skills labs designed to build embodied belief and regulate your nervous system so you can coach from grounded authority. Certification details: Tuition $10,000. Payment plan available: $1,667/month for 6 months. Admissions decisions are made within 24–48 hours of application review, followed by an admissions call to finalize enrollment.Links & next stepsApply now: thedoctorcoachschool.com/applynowQuestions: support@thedoctorcoachschool.comAdmissions line: 844-432-7457 (toll-free) Let's Connect: On Instagram On Facebook On LinkedIn On TikTok On my website

This Week in Virology
TWiV 1261: Must-see TVs

This Week in Virology

Play Episode Listen Later Oct 12, 2025 110:19


TWiV covers a MacArthur Award for Jason McLellan, 2025 Nobel Prizes in Physiology or Medicine, first treatment for Huntington's Disease, structure of an archael dsDNA virus from head to tail, and discovery of a Legionella phage that explains a determinant of human disease. Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Jason McLellan wins MacArthur Award (NPR) 2025 Nobel Prizes Physiology or Medicine (Nobel Prizes) Huntington Disease treatment (BBC) Structure of archaeal tailed virus (Sci Adv) Discovery of Legionella phage (Sci Adv) Microbe of the Month: Legionella (Trends Micro) Letters read on TWiV 1261 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Alan – Specimen of the last female Great Auk finally identified. Jolene – Ribosome studio on IG Vincent – Greater noctule bats prey on and consume passerines in flight Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Science Friday
An Off-The-Grid Nobel Win, And Antibiotics In Ancient Microbes

Science Friday

Play Episode Listen Later Oct 11, 2025 18:31


This year's Nobel Prize in Physiology or Medicine went to three people whose combined discoveries outlined the role of the peripheral immune system—how the immune system knows to attack just foreign invaders and not its own tissues and organs. But when the phone rang for Shimone Sakaguchi, Mary E. Brunkow, and Fred Ramsdell, only two of them picked up.Host Ira Flatow talks with Nobel Prize winner Fred Ramsdell, co-founder and scientific advisor at Sonoma Biotherapeutics.Plus, Ira talks with bioengineering professor César de la Fuente, who looks for solutions to the antibiotic resistance crisis in unexpected places. Now, he's used AI to help identify promising antibiotic candidates lurking in ancient archaea, small organisms that can survive some of the most extreme conditions in the world.Guests:Dr. Fred Ramsdell is the co-founder and scientific advisor at Sonoma Biotherapeutics.Dr. César de la Fuente is an associate professor of bioengineering at the University of Pennsylvania.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Sliced Bread
Creatine

Sliced Bread

Play Episode Listen Later Oct 9, 2025 30:50


Can creatine boost your body and mind?Listener Simon has been taking the fitness supplement creatine and wants to know if the science backs up the claim that it can make you stronger and faster. He's also heard that it can help with cognitive function. To find out if creatine can boost body and mind, presenter Greg Foot is joined by Graeme Close, Professor of Physiology at Liverpool John Moores University and Fabienne Sandkuhler, postdoctoral researcher at LMU Munich.Each episode Greg investigates the latest ad-hyped products and trending fads promising to make us healthier, happier and greener. Are they really 'the best thing since sliced bread' and should you spend your money on them?All of our episodes start with YOUR suggestions. If you've seen an ad, trend or wonder product promising to make you happier, healthier or greener, email us at sliced.bread@bbc.co.uk OR send a voice note to our WhatsApp number, 07543 306807.RESEARCHER: PHIL SANSOM PRODUCERS: SIMON HOBAN AND GREG FOOT

Health & Veritas
Crowded Emergency Rooms and Other News

Health & Veritas

Play Episode Listen Later Oct 9, 2025 38:48


Howie and Harlan discuss the roots of the crisis in emergency departments, the lack of oversight for hydration spas, new approaches in blood pressure treatment, an ingenious method to prevent malaria, and the CDC's backward steps on vaccines. Links: Emergency Departments “I'm an ER doctor. JD Vance's claims about immigrants and wait times are just wrong.” “It's Just a Virus, the E.R. Told Him. Days Later, He Was Dead.” Video of Ron Paul: “Should society let uninsured die?” American College of Emergency Physicians: Understanding EMTALA “Explaining the G.O.P.'s Misleading Talking Point on the Looming Shutdown” Centers for Medicare and Medicaid: Emergency Medical Treatment & Labor Act (EMTALA) Health & Veritas Ep. 188: Kate Heilpern: Jumping into the Deep End Health & Veritas Ep. 47: Dr. Jeremy Faust: Is COVID Over? It's Complicated. Jeremy Faust: “Inside Medicine Read-Through: Commentary on the New York Times article about a tragic ER case” Harlan Krumholz: “Early Warning Scores With and Without Artificial Intelligence” Howard Forman: “Why Hospitals Need to Stop Boarding Patients in Emergency Rooms” Howard Forman: “How to Keep Emergency Rooms Focused on True Emergencies” The Revolving Door “Peter Marks, FDA vaccine regulator ousted by RFK Jr., joins Eli Lilly” Peter Marks Resignation Letter “Peter Marks, FDA's top vaccine regulator, forced out” “Fired C.D.C. Director Describes Clashes With Kennedy and Turmoil at Agency” “Ex-CDER chief Patrizia Cavazzoni becomes Pfizer's chief medical officer” Hydration Spas Howard Forman: “State Policies and Facility Practices of IV Hydration Spas in the US” Health & Veritas Ep. 123: Margo Harrison: Women's Health as a Path to Empowerment “Hydration spas are largely unregulated, study finds” New Developments in Blood Pressure Treatment “Baxdrostat met the primary endpoint in Bax24 Phase III trial in patients with resistant hypertension” “AstraZeneca's $1.3B bet yields 2nd phase 3 blood pressure win, bolstering differentiation case” Harlan Krumholz: “The Disquieting Plateau” “Under new guidelines, more Americans meet the criteria for high blood pressure” “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines” “Permethrin-Treated Baby Wraps for the Prevention of Malaria” AI in Medicine: Doximity, OpenEvidence, and UpToDate “OpenEvidence raises $210M, unveils AI agents built for advanced medical research” Health & Veritas, Ep. 183: Seth Berkowitz: The Power Problem “Doximity buys Pathway Medical for $63 million to help doctors get AI-powered answers” “A long-trusted physician's reference finally catches the AI wave” Congenital syphilis Health & Veritas Ep. 178: Sarah DeSilvey: Creating Space for Healing “Are STIs truly declining, or is our data just not very good? What the 2024 CDC STI report really shows” “Why Syphilis Cases in Newborns Are Rising Even as STIs Decline” MMR Vaccine “Acting CDC director calls to 'break up' the measles, mumps and rubella vaccine into three shots” “Worried about splitting up the MMR vaccine into three separate shots? You should be, this doctor says” “More measles cases confirmed in South Carolina, Michigan as US total climbs to 1,563” Nobel Prizes and Science at Yale “Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems” “Nobel Prize in Physiology or Medicine 2025” “Yale's Michel H. Devoret wins 2025 Nobel Prize in Physics” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Sliced Bread
Creatine

Sliced Bread

Play Episode Listen Later Oct 9, 2025 30:50


Can creatine boost your body and mind?Listener Simon has been taking the fitness supplement creatine and wants to know if the science backs up the claim that it can make you stronger and faster. He's also heard that it can help with cognitive function. To find out if creatine can boost body and mind, presenter Greg Foot is joined by Graeme Close, Professor of Physiology at Liverpool John Moores University and Fabienne Sandkuhler, postdoctoral researcher at LMU Munich.Each episode Greg investigates the latest ad-hyped products and trending fads promising to make us healthier, happier and greener. Are they really 'the best thing since sliced bread' and should you spend your money on them?All of our episodes start with YOUR suggestions. If you've seen an ad, trend or wonder product promising to make you happier, healthier or greener, email us at sliced.bread@bbc.co.uk OR send a voice note to our WhatsApp number, 07543 306807.RESEARCHER: PHIL SANSOM PRODUCERS: SIMON HOBAN AND GREG FOOT

Health Check
Immune system researchers win Nobel Prize

Health Check

Play Episode Listen Later Oct 8, 2025 26:30


This year's Nobel Prize in Physiology or Medicine has been awarded for discoveries that explain how the immune system attacks hostile infections, but not the body's own cells. We explain the science that won Japan's Shimon Sakaguchi and US researchers Mary Brunkow and Fred Ramsdell the prestigious award.How robots can help children with reading anxiety. Lauren Wright from the University of Chicago who led this research explains.A new targeted antibiotic has been found that treats Inflammatory Bowel Disease. Dr Graham Easton who is Professor of Clinical Communication Skills at Queen Mary University of London describes how it works.Missing your first mammogram appointment has as much impact on breast cancer outcomes than an inherited genetic risk according to new research. Ziyan Ma from the Department of Medical Epidemiology and Biostatistics at the Karolinska Institute tells us more.And should we reconsider how we treat blood pressure? Presenter: Claudia Hammond Producer: Katie Tomsett

Nobel Prize Conversations
First reactions | Fred Ramsdell, Nobel Prize in Physiology or Medicine | telephone interview

Nobel Prize Conversations

Play Episode Listen Later Oct 7, 2025 10:11


“I was out walking the dogs and she started yelling, and I thought there was a grizzly bear nearby.” Actually, what Fred Ramsdell's wife was telling him, while on a hiking trip together, was that he had been awarded the 2025 Nobel Prize in Physiology or Medicine. In this conversation with the Nobel Prize's Adam Smith, recorded early the following day, Ramsdell recall how the realisation dawned on them. He goes on to speak about the benefits of working in the environment of biotech, the joy of finding talented collaborators, and the importance of celebrating the dedication of those that nurtured hundreds of generations of the all-important scurfy mouse, in which he and Mary Brunkow discovered the FOXP3 gene: “I'm really in awe of the fact that they were able to do that for so long. It's incredible.” © Nobel Prize Outreach.First reactions terms of use: https://www.nobelprize.org/ceremonies/streams-terms-of-use Hosted on Acast. See acast.com/privacy for more information.

Peak Performance Life Podcast
EPI 220: The INCREDIBLE Benefits Of Going PALEO With Mark J. Smith, Ph.D. & How Peak Performance Founder Talor Zamir Lowered Inflammation & Got Rid Of His Pain By Going Paleo. Plus The Fastest Workout That Has INSANE Benefits (Anyone Can Do It).

Peak Performance Life Podcast

Play Episode Listen Later Oct 7, 2025 63:08


Show notes: (0:00) Intro (2:21) Dr. Smith's early work with Dr. Loren Cordain (4:31) The original research behind Paleo (7:08) Autoimmune healing (9:51) How Paleo can reduce pain, inflammation, and possibly avoid operations (13:18) The 3-part food rule (15:30) How your cravings fade and your palate resets (18:06) Paleo For Life (22:19) The average person's results on Paleo (26:35) Paleo ranks #1 for lowering inflammation and blood sugar (30:20) Easy Paleo swaps that taste better (36:33) What is Supra Maximal Interval Training (SMIT)? (45:41) How to get started with SMIT (53:35) Dr. Smith's self-experiment (58:05) Where to learn more, get recipes, tools, and pre-order the book (1:00:17) Outro Who is Mark J. Smith Ph.D.?   Dr. Smith obtained a bachelor's degree in PE & Sports Science and a teaching certificate in PE & Mathematics from Loughborough University, England. He completed both his master's degree (Exercise and Sport Science) and his doctorate (Physiology) at Colorado State University. He has worked with Dr. Cordain, the founder of the modern Paleo diet movement, since 1988. Dr. Smith is also a leading expert on supra-maximal interval training. He has maintained his own health and conditioning practice at The Sports Club at Mission Hills CC in Rancho Mirage, CA since 2006.   Connect with Dr. Smith: Website: https://thepaleodiet.com/ https://docsmith.org/   Grab a copy: https://thepaleodiet.com/resources/paleo-for-life/ Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram  

Hacker News Recap
October 6th, 2025 | Ladybird passes the Apple 90% threshold on web-platform-tests

Hacker News Recap

Play Episode Listen Later Oct 7, 2025 14:37


This is a recap of the top 10 posts on Hacker News on October 06, 2025. This podcast was generated by wondercraft.ai (00:30): Ladybird passes the Apple 90% threshold on web-platform-testsOriginal post: https://news.ycombinator.com/item?id=45493358&utm_source=wondercraft_ai(01:53): Why do LLMs freak out over the seahorse emoji?Original post: https://news.ycombinator.com/item?id=45487044&utm_source=wondercraft_ai(03:16): 1 Trillion Web Pages ArchivedOriginal post: https://news.ycombinator.com/item?id=45487476&utm_source=wondercraft_ai(04:39): Gem.coopOriginal post: https://news.ycombinator.com/item?id=45487771&utm_source=wondercraft_ai(06:02): Structured Procrastination (1995)Original post: https://news.ycombinator.com/item?id=45488261&utm_source=wondercraft_ai(07:26): AMD signs AI chip-supply deal with OpenAI, gives it option to take a 10% stakeOriginal post: https://news.ycombinator.com/item?id=45490549&utm_source=wondercraft_ai(08:49): Apps SDKOriginal post: https://news.ycombinator.com/item?id=45494558&utm_source=wondercraft_ai(10:12): Nobel Prize in Physiology or Medicine 2025Original post: https://news.ycombinator.com/item?id=45489533&utm_source=wondercraft_ai(11:35): Mise: Monorepo TasksOriginal post: https://news.ycombinator.com/item?id=45491621&utm_source=wondercraft_ai(12:59): OpenZL: An open source format-aware compression frameworkOriginal post: https://news.ycombinator.com/item?id=45492803&utm_source=wondercraft_aiThis is a third-party project, independent from HN and YC. Text and audio generated using AI, by wondercraft.ai. Create your own studio quality podcast with text as the only input in seconds at app.wondercraft.ai. Issues or feedback? We'd love to hear from you: team@wondercraft.ai

Becoming the Channel with Robyn McKay
The Art of Becoming: From Fitness to Creative Purpose & True Transformation

Becoming the Channel with Robyn McKay

Play Episode Listen Later Oct 7, 2025 22:48


In this eye-opening conversation, Robyn is joined by one of her very first clients, self-taught mixed media artist Laura Madden, to share her journey of transformation from fitness to life coaching, and ultimately answering her calling in the arts.This episode explores:How Laura transitioned from fitness to life coachingFinding the alignment between your gifts and your soulWhy we start with the neo-personality profileHarnessing creativity through upcyclingBringing beauty into the worldFinding fulfillment through artLaura's turning point toward visibilityWhy many artists struggle with self-consciousnessHow art is often dismissed as just a hobbyWomen's fear of invisibility and becoming irrelevantMaking life changes through art reveals a deeper purpose. You're not weird for following what fulfills your heart — it's a process of becoming.Love what you're hearing?Leave a review on Apple Podcasts and send a screenshot to Robyn. Each month, one listener will receive a Scroll of Recognition—a custom energetic blessing, activation, or intuitive message written just for you.Laura Madden is a self-taught mixed media artist based in Phoenix, Arizona. Originally from Boston, Massachusetts, she reimagines reclaimed materials and found objects—items that might otherwise be dismissed as disreputable or disposable—as the foundation of her artistic practice. In 2019, she made the decision to pursue art professionally after recognizing it as her true life's calling. Madden's creative path began with a Bachelor of Science in Kinesiology and Physiology from the University of New Hampshire, where she graduated summa cum laude. She spent 15 years working in the fitness industry before transitioning into sustainable fashion— a field that continues to inform her work. Drawing inspiration from her passion for the environment, design, and the intersection of beauty and sustainability, Madden creates layered, textural works that are both elegant and evocative.Connect with Laura Madden:Website: https://www.lauramaddenstudio.com/ Instagram: https://www.instagram.com/lauramaddenstudioRobyn McKay, PhD, is an award-winning therapist and psychospiritual advisor who teaches and leads at the intersection of psychology × spirituality × energetics. With deep roots in clinical psychology and a lifetime of living at the crossroads of intuition and credentials, she is a rare bridge between science and soul, credentials and codes, strategy and spirit.Early in her career, Robyn served as a university psychologist before stepping into her broader calling as a guide for high performers, creatives, and seekers. She addresses a wide spectrum of human experience — healing trauma, anxiety, depression, mood disorders, and ADHD in women; accessing spiritual gifts; and navigating existential crossroads.Having sold $2.5M+ in retreats and private intensives, Robyn is now architecting an entirely new category of retreats: expert-led, trauma-informed, miracle-level. She helps credentialed, neurodivergent, and spiritually awake women leaders design transformational retreats that carry depth, meaning, and lasting impact.Connect with Dr. Robyn McKay:LinkedIn: Robyn McKay, PhDFacebook: Dr. Robyn McKayInstagram: @robynmckayphd Book a call with Dr. Robyn! https://drrobynmckay.com/call Join the $100K Retreat Leaders Secrets: https://www.facebook.com/groups/100kretreatsecrects 

Nobel Prize Conversations
First reactions | Shimon Sakaguchi, Nobel Prize in Physiology or Medicine 2025 | Telephone interview

Nobel Prize Conversations

Play Episode Listen Later Oct 6, 2025 6:23


"I believe this will encourage immunologists and physicians to apply the T regulatory cells to treat various immunological diseases.” Shimon Sakaguchi, 2025 Nobel Prize laureate in physiology or medicine, has always been driven by the desire to find new ways to combat disease. In this conversation with the Nobel Prize's Adam Smith, recorded just after the prize announcement, Sakaguchi speaks briefly about his surprise at the news and reflects on the fundamental research question that kept him dedicated to the field after many others abandoned it, a question that took over two decades to answer.© Nobel Prize Outreach.First Reactions terms of use: https://www.nobelprize.org/ceremonies/streams-terms-of-use Hosted on Acast. See acast.com/privacy for more information.

Nobel Prize Conversations
First reactions | Mary Brunkow, Nobel Prize in Physiology or Medicine 2025 | Telephone interview

Nobel Prize Conversations

Play Episode Listen Later Oct 6, 2025 5:50


“My phone rang, and I saw a number from Sweden and thought, well that's just spam of some sort, so I disabled the phone and went back to sleep.” Mary Brunkow clearly wasn't expecting the call from Stockholm. This brief conversation with the Nobel Prize's Adam Smith catches the new medicine laureate at her dining table at 4:30am, an hour and a half after she had heard the news. She talks about the power of genetics to unravel biology and how she feels it was an honour to have been one of the contributors to solving the puzzle of immune tolerance: “It takes a bunch of different brains, all working on it together, for sure!” © Nobel Prize Outreach.First Reactions terms of use: https://www.nobelprize.org/ceremonies/streams-terms-of-use Hosted on Acast. See acast.com/privacy for more information.

Live By Design Podcast | Release Overwhelm, Get Unstuck, & Take Action | Via Goals, Habits, Gratitude, & Joy

Alisa Gracheva joins the show to tackle the invisible force that can secretly halt your authority and stall your business scale: unresolved trauma and deep-seated limiting beliefs. Alisa, who has walked a powerful healing journey herself, breaks down what trauma truly is and how it's encoded in your physiology as negative beliefs that keep you playing small.This conversation is the deep dive into the mindset block and unseen resistance that we often experience, including:

Feel Better, Live More with Dr Rangan Chatterjee
How Food, Fasting & Lifestyle Can Transform Your Metabolic Health & Reduce Your Risk of Disease with Dr Ben Bikman #582

Feel Better, Live More with Dr Rangan Chatterjee

Play Episode Listen Later Sep 30, 2025 137:05


Most of us will never have our insulin levels tested, yet this single hormone is the body's master regulator of energy. When it stops working properly, almost every system in the body is affected, from how we store fat, to how we age. Today's guest is Dr Ben Bikman, a scientist and world-leading expert on insulin and metabolism. He's a Professor in the Department of Physiology and Developmental Biology at Brigham Young University (BYU) and has spent years researching how changes inside our cells lead to common metabolic disorders, such as obesity, type 2 diabetes, and dementia. He frequently publishes his research in peer-reviewed journals, speaks at scientific conferences all over the world and is the author of 2 books, Why We Get Sick and How Not to Get Sick. In this conversation, we discuss: Why insulin is the body's “master hormone”, guiding how we store and use energy and how resistance to it can cause a wide range of chronic health problems. The fact that almost 9 in 10 adults show signs of poor metabolic health, and why this is a global issue that affects countries far beyond the United States. How ethnicity and genetics shape the way we store fat, explaining why two people of the same weight and size can face very different risks of conditions like type 2 diabetes or heart disease. Why focusing only on blood glucose misses the early warning signs of poor metabolic health, and why measuring insulin levels offers a clearer and earlier picture of risk. The visible clues your body may already be giving you – such as skin tags or darker, velvety patches of skin around the neck or armpits – that can indicate chronically elevated insulin. Practical strategies to bring insulin down, from reducing refined sugars and starches to spacing out meals and experimenting with fasting in ways that work for both men and women. So often, we're told that chronic illnesses are inevitable or a natural part of ageing. But as Ben explains, many of these conditions have a common origin – and by focusing on insulin resistance, we can take powerful steps towards prevention and even reversal. This conversation is not about fear, but empowerment. It's a reminder that our everyday choices – how and what we eat, how we move, and how often we give our bodies a rest from food – can profoundly influence our future health. I hope you enjoy listening. Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.   Thanks to our sponsors: https://www.vivobarefoot.com/livemore https://thriva.co/ https://www.boncharge.com/livemore   Show notes https://drchatterjee.com/582   DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

The John Batchelor Show
SEGMENT: Koala Diet, Physiology, and Adaptation to Eucalyptus GUEST NAME: Professor Danielle Clode SUMMARY: Professor Danielle Clode discusses how koalas overcome toxic, fibrous eucalyptus leaves using a massive, microbe-filled cecum for digestion. Their

The John Batchelor Show

Play Episode Listen Later Sep 21, 2025 7:05


SEGMENT: Koala Diet, Physiology, and Adaptation to Eucalyptus GUEST NAME: Professor Danielle Clode SUMMARY: Professor Danielle Clode discusses how koalas overcome toxic, fibrous eucalyptus leaves using a massive, microbe-filled cecum for digestion. Their evolutionarily complex teeth function like "pinking shears." 1939 ZANE GRAY