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Dr. Balcavage's new book, Is This The Hill?, is now available. Go to drericbalcavage.com/hill for the information or to order. ---------- Is your thyroid medication helping your lab numbers... but you're still exhausted, cold, struggling with brain fog, or unable to lose weight? In this episode, Dr. Eric Balcavage challenges one of the biggest misconceptions in thyroid care: that replacing thyroid hormone is the same as restoring healthy thyroid function. While thyroid medication and supplements can absolutely play an important role, they don't always address why your thyroid physiology changed in the first place. Instead of viewing the thyroid as an isolated gland that simply "stopped working," Dr. Eric explains why altered thyroid function is often an adaptive response to the signals your body receives every day. One of the most powerful—and often overlooked—factors influencing thyroid physiology is your daily rhythm. Your sleep, meal timing, stress levels, movement, recovery, light exposure, and even your work habits all send signals to your nervous system, immune system, and metabolism. Those repeated signals help determine whether your body feels safe enough to support healthy thyroid function or whether it remains in a protective, energy-conserving state. In this episode, you'll learn: Why thyroid hormone replacement isn't the same as thyroid recovery The limitations of relying solely on thyroid support supplements Why low thyroid physiology is often an adaptive response rather than a "broken" thyroid How your body's daily rhythms influence thyroid physiology Common routines that may unintentionally keep your body in a state of stress Why recovery often requires changing the signals your body receives—not just changing medications or supplements A practical "Thyroid Recovery Rhythm Audit" to help identify patterns that may be affecting your thyroid health If you've been chasing better labs but still don't feel like yourself, this episode offers a different way to think about thyroid recovery... one that looks beyond numbers and focuses on creating the internal environment your body needs to heal. Resources Mentioned: ➡️ Download the Thyroid Recovery Blueprint to begin identifying the stressors, signals, and patterns that may be influencing your thyroid physiology. If this episode was helpful, be sure to subscribe, leave a review, and share it with someone who's been told "everything looks normal" but still doesn't feel well. Need help understanding your symptoms? If you've been struggling with fatigue, thyroid symptoms, or chronic health issues despite trying multiple treatment approaches, schedule a complimentary Discovery Call to learn whether Dr. Eric's State-Based Medicine™ approach may be right for you.
Andrew McGonigle, author of The Physiology of Yoga, talks with J about the confluence of studying medicine, teaching anatomy, and finding identity. They discuss going to medical school at a young age, transcendental meditation, getting a job at TriYoga, moving to California, debunking misleading claims, addressing pain, shoulder surgeries and knee replacements, professional landscapes, being a teacher, down-regulation, reasons for asana, relationship to aging, engaging spiritual aspects, and developing a sense of inquiry and awe. To subscribe and support the show… GET PREMIUM. Say thank you - buy J a coffee. Check out J's other podcast… J. BROWN YOGA THOUGHTS.
If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects. In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge. So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below. Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBibliographyCore Eye Anatomy, Retina, Optic Nerve, and Visual PathwaysBelliveau, A. P., & Somani, A. N. “Pupillary Light Reflex.” StatPearls. Treasure Island, FL: StatPearls Publishing, updated 2023.Cleveland Clinic. “Optic Nerve: What It Is, Function, Anatomy & Conditions.” Cleveland Clinic, updated 2024.Gupta, M., & Ireland, A. C. “Neuroanatomy, Visual Pathway.” StatPearls. Treasure Island, FL: StatPearls Publishing, updated 2022.Kolb, H. “Simple Anatomy of the Retina.” Webvision: The Organization of the Retina and Visual System. University of Utah / NCBI Bookshelf.Purves, D., Augustine, G. J., Fitzpatrick, D., et al., eds. Neuroscience. Sunderland, MA: Sinauer Associates.Szabadi, E. “Functional Organization of the Sympathetic Pathways Controlling the Pupil: Light-Inhibited and Light-Stimulated Pathways.” Frontiers in Neurology 9, 2018.University of Texas Health Science Center at Houston. “Ocular Motor System.” Neuroscience Online.Pupillometry, Cognitive Load, Attention, and Mental EffortBeatty, Jackson. “Task-Evoked Pupillary Responses, Processing Load, and the Structure of Processing Resources.” Psychological Bulletin 91, no. 2, 1982: 276–292.Beatty, Jackson, and Brennis Lucero-Wagoner. “The Pupillary System.” In Handbook of Psychophysiology, edited by John T. Cacioppo, Louis G. Tassinary, and Gary G. Berntson. Cambridge: Cambridge University Press, 2000.Kahneman, Daniel, and Jackson Beatty. “Pupil Diameter and Load on Memory.” Science 154, no. 3756, 1966: 1583–1585.Kahneman, Daniel. Attention and Effort. Englewood Cliffs, NJ: Prentice-Hall, 1973.Laeng, Bruno, Sylvain Sirois, and Gustaf Gredebäck. “Pupillometry: A Window to the Preconscious?” Perspectives on Psychological Science 7, no. 1, 2012: 18–27.Mathôt, Sebastiaan. “Pupillometry: Psychology, Physiology, and Function.” Journal of Cognition 1, no. 1, 2018.Piquado, Tepring, David Isaacowitz, and Arthur Wingfield. “Pupillometry as a Measure of Cognitive Effort in Younger and Older Adults.” Psychophysiology 47, no. 3, 2010: 560–569.Zekveld, Adriana A., Sophia E. Kramer, and Tammo Houtgast. “The Pupil Dilation Response to Auditory Stimuli: Current State of Knowledge.” Trends in Hearing 22, 2018.Emotion, Attraction, Arousal, and the PupilBradley, Margaret M., Laura Miccoli, Miguel A. Escrig, and Peter J. Lang. “The Pupil as a Measure of Emotional Arousal and Autonomic Activation.” Psychophysiology 45, no. 4, 2008: 602–607.de Winter, Joost C. F., et al. “Replicating Five Pupillometry Studies of Eckhard Hess.” International Journal of Psychophysiology 165, 2021: 145–161.Hess, Eckhard H. “Attitude and Pupil Size.” Scientific American 212, no. 4, 1965: 46–54.Hess, Eckhard H., and James M. Polt. “Pupil Size as Related to Interest Value of Visual Stimuli.” Science 132, no. 3423, 1960: 349–350.Lang, Peter J., Margaret M. Bradley, and Bruce N. Cuthbert. International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Gainesville: University of Florida, 2008.Pan, J., et al. “The Effects of Emotional Arousal on Pupil Size Depend on Background Luminance and Stimulus Type.” Scientific Reports 14, 2024.Locus Coeruleus, Norepinephrine, Salience, and AttentionAston-Jones, Gary, and Jonathan D. Cohen. “An Integrative Theory of Locus Coeruleus–Norepinephrine Function: Adaptive Gain and Optimal Performance.” Annual Review of Neuroscience 28, 2005: 403–450.Joshi, Siddhartha, Yin Li, Ram M. Kalwani, and Joshua I. Gold. “Relationships Between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex.” Neuron 89, no. 1, 2016: 221–234.Murphy, Peter R., Ian H. Robertson, James H. Balsters, and Redmond G. O'Connell. “Pupillometry and P3 Index the Locus Coeruleus–Noradrenergic Arousal Function in Humans.” Psychophysiology 48, no. 11, 2011: 1532–1543.Sara, Susan J. “The Locus Coeruleus and Noradrenergic Modulation of Cognition.” Nature Reviews Neuroscience 10, 2009: 211–223.Uddin, Lucina Q. “Salience Processing and Insular Cortical Function and Dysfunction.” Nature Reviews Neuroscience 16, 2015: 55–61.Memory, Emotion, Initiation, and Ritual EncodingCahill, Larry, and James L. McGaugh. “Mechanisms of Emotional Arousal and Lasting Declarative Memory.” Trends in Neurosciences 21, no. 7, 1998: 294–299.McGaugh, James L. “Memory—A Century of Consolidation.” Science 287, no. 5451, 2000: 248–251.McGaugh, James L. “The Amygdala Modulates the Consolidation of Memories of Emotionally Arousing Experiences.” Annual Review of Neuroscience 27, 2004: 1–28.Seligman, Rebecca, and Laurence J. Kirmayer. “Dissociative Experience and Cultural Neuroscience: Narrative, Metaphor and Mechanism.” Culture, Medicine, and Psychiatry 32, 2008: 31–64.Seligman, Rebecca, Ryan A. Brown, and Laurence J. Kirmayer. “Theory and Method at the Intersection of Anthropology and Cultural Neuroscience.” Social Cognitive and Affective Neuroscience 5, no. 2–3, 2010: 130–139.Whitehouse, Harvey. Arguments and Icons: Divergent Modes of Religiosity. Oxford: Oxford University Press, 2000.Whitehouse, Harvey. Modes of Religiosity: A Cognitive Theory of Religious Transmission. Walnut Creek, CA: AltaMira Press, 2004.Ritual, Synchrony, Social Bonding, and Embodied MeaningHobson, Nicholas M., Juliana Schroeder, Jane L. Risen, Dimitris Xygalatas, and Michael I. Norton. “The Psychology of Rituals: An Integrative Review and Process-Based Framework.” Personality and Social Psychology Review 22, no. 3, 2018: 260–284.Jackson, Joshua Conrad, Brock Bastian, and others. “Synchrony and Physiological Arousal Increase Cohesion and Cooperation in Large Naturalistic Groups.” Scientific Reports 8, 2018.McCauley, Robert N., and E. Thomas Lawson. Bringing Ritual to Mind: Psychological Foundations of Cultural Forms. Cambridge: Cambridge University Press, 2002.Rappaport, Roy A. Ritual and Religion in the Making of Humanity. Cambridge: Cambridge University Press, 1999.Turner, Victor. The Ritual Process: Structure and Anti-Structure. Chicago: Aldine, 1969.Xygalatas, Dimitris. Ritual: How Seemingly Senseless Acts Make Life Worth Living. New York: Little, Brown Spark, 2022.Xygalatas, Dimitris, et al. “Extreme Rituals Promote Prosociality.” Psychological Science 24, no. 8, 2013: 1602–1605.Meditation, Prayer, Trance, and AbsorptionFox, Kieran C. R., Matthew L. Dixon, Savannah Nijeboer, et al. “Functional Neuroanatomy of Meditation: A Review and Meta-Analysis of 78 Functional Neuroimaging Investigations.” Neuroscience & Biobehavioral Reviews 65, 2016: 208–228.Jerath, Ravinder, John W. Crawford, Vernon A. Barnes, and Kyler Harden. “Self-Regulation of Breathing as a Primary Treatment for Anxiety.” Applied Psychophysiology and Biofeedback 40, 2015: 107–115.Lutz, Antoine, John D. Dunne, and Richard J. Davidson. “Meditation and the Neuroscience of Consciousness.” In The Cambridge Handbook of Consciousness, edited by Philip David Zelazo, Morris Moscovitch, and Evan Thompson. Cambridge: Cambridge University Press, 2007.Tellegen, Auke, and Gilbert Atkinson. “Openness to Absorbing and Self-Altering Experiences (‘Absorption'), a Trait Related to Hypnotic Susceptibility.” Journal of Abnormal Psychology 83, no. 3, 1974: 268–277.Vago, David R., and David A. Silbersweig. “Self-Awareness, Self-Regulation, and Self-Transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6, 2012.Darkness, Sensory Deprivation, Ganzfeld, and Visual InstabilityCaputo, Giovanni B. “Strange-Face-in-the-Mirror Illusion.” Perception 39, no. 7, 2010: 1007–1008.Caputo, Giovanni B. “Visual Perception During Mirror-Gazing at One's Own Face in Patients with Depression.” The Scientific World Journal, 2014.Caputo, Giovanni B. “Strange-Face Illusions During Eye-to-Eye Gazing in Dyads.” Imagination, Cognition and Personality 38, no. 1, 2018: 51–77.Metzger, Wolfgang. “Optische Untersuchungen am Ganzfeld.” Psychologische Forschung 13, 1930: 6–29.Shenyan, O., et al. “Visual Hallucinations Induced by Ganzflicker and Ganzfeld Differ in Frequency, Complexity, and Content.” Scientific Reports 14, 2024.Wackermann, Jiří, Peter Pütz, and Carsten Allefeld. “Ganzfeld-Induced Hallucinatory Experience, Its Phenomenology and Cerebral Electrophysiology.” Cortex 44, no. 10, 2008: 1364–1378.Zuckerman, Marvin, and Nathan Cohen. “Sources of Reports of Visual and Auditory Sensations in Perceptual-Isolation Experiments.” Psychological Bulletin 61, no. 1, 19Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball.
Your liver and blood sugar are far more connected than most people realize. In this episode, Nurse Doza walks through five links between the two: how the liver stores and releases glucose, where insulin resistance actually begins, how stress and cortisol raise blood sugar without food, how all of it lands on your mitochondria, and what obesity has to do with the whole picture. Featured Product The Metabolic Pack bundles the three formulas this episode keeps circling back to: Liver Boost to support phase I and phase II liver detoxification pathways, Mitochondriac for resveratrol, quercetin and pterostilbene to support cellular energy production, and Zen to support a healthy stress and cortisol response. Liver, cellular energy, and stress — supported together in one simple daily protocol. Suggested use: 2 Liver Boost, 1 Mitochondriac, and 1 Zen daily with food.
In this episode, top biomechanics researcher Professor Kris D'Aout joins the show to break down the actual science behind minimalist footwear, foot muscle architecture, and running economy. We dive into how ditching traditional high-cushion trainers impacts ground reaction forces, arch strength, and injury risk patterns across different athletic populations. Whether you are looking to optimize force production or safely transition your footwear strategy, discover the evidence-based realities of bare-minimum footwear for long-term athletic durability.
When was the last time you looked at a river in Malaysia and actually wanted to get near it? Between toxic runoffs, plastic waste, and endless degradation, our waterways are crying for help - and waiting for a cleanup crew isn't going to cut it anymore.In this episode of RealiTEA Podcast, hosts Diyaanah, Danisha, Airil, and Dania sit down with Dr. Razif Bin Dasiman, Senior Lecturer in Physiology, researcher at the Zebrafish and Disease Modeling Research Laboratory (ZEPP) at UiTM, and passionate environmental advocate. Together, we unpack the hidden health and ecological impacts of river pollution, how zebrafish are telling us more about water safety than we think, and why community education is our strongest tool to turn the tide.Inspired by SDG 4.7, we explore how bridging scientific research with grassroots awareness can empower Gen Z and everyday Malaysians to protect our rivers before it's too late. Hit play to get educated, get inspired, and learn how small actions can save our streams.We're on socials!Twitter: @realiteapodcas1TikTok: @realiteaktok#RealiTEAPodcast #VoicesOfTheRiver #RiverConservationMY #SDG47 #EcoRealTalk #CleanWaterMatters #YouthForNature #ScienceForChangeHead Producer: Dr. A. Hamid Saifuddin
Send us Fan MailIn this prospective study, Adrianne and Nim dig into an area with almost no normative pediatric data: right ventricular diastolic function. Comparing 57 infants with RV pressure overload after intervention for pulmonic stenosis or tetralogy of Fallot to 134 healthy controls, the authors found a consistent pattern, reduced beat-to-beat variability, a higher atrial contribution to filling, and an E/A ratio inversion that was nearly universal in the CHD group versus about half of controls. It's one of the first real attempts to define what a right-sided diastolic pattern actually looks like in this population. But without a comparison against cardiac catheterization, the hosts agree the findings are hypothesis-generating at best, a starting point for a multi-parametric approach, not a reason to skip an invasive workup.----Echocardiographic Markers of Right Ventricle Diastolic Dysfunction in Neonates and Infants with Congenital Heart Disease. Cantinotti M, Capponi G, Scalese M, Palladino E, Giordano R, Franchi E, Viacava C, Corana G, Marchese P, Pizzuto A, Assanta N, Santoro G. J Clin Med. 2025 Dec 23;15(1):98. doi: 10.3390/jcm15010098. PMID: 41517351 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Huxley is an example of having a good attitude about publicly acknowledging errors and learning from them. He earned the nickname “Darwin’s bulldog” for his very vocal support of Darwin’s work, and he wanted to promote science and education, particularly to people that didn’t normally have access to those things. Research: Bernoulli, D., Jenkyns, H.C. “Thomas Henry Huxley, a stone tablet, coccoliths, and deep-sea sediments in the high Alps.” Int J Earth Sci (Geol Rundsch) 112, 1661–1669 (2023). https://doi.org/10.1007/s00531-023-02330-5 Bowen, Keith. “Thomas Henry Huxley.” Ebsco. 2024. https://www.ebsco.com/research-starters/history/thomas-henry-huxley Burkhardt, Richard W.. "Jean-Baptiste Lamarck". Encyclopedia Britannica, 14 Dec. 2025, https://www.britannica.com/biography/Jean-Baptiste-Lamarck Darwin, Charles. “On the Origin of Species.” JOHN MURRAY, ALBEMARLE STREET. London. 1859. https://www.gutenberg.org/files/1228/1228-h/1228-h.htm Desmond, Adrian J. "Thomas Henry Huxley". Encyclopedia Britannica, 25 Jun. 2026, https://www.britannica.com/biography/Thomas-Henry-Huxley Dolan, John R. “The famous and lesser-known illustrations of Thomas Huxley’s Bathybius.” History of Oceanography. International Commission of the History of Oceanography. https://oceansciencehistory.com/2020/07/13/the-famous-and-lesser-known-illustrations-of-thomas-huxleys-bathybius/ “Freshwater Bathybius.” Nature 4, 49–50 (1871). https://doi.org/10.1038/004049b0 “The Great Debate.” University of Oxford Museum of Natural History. https://oumnh.ox.ac.uk/great-debate “The History of Evolutionary Thought.” Understanding Evolution. Berkeley University. https://evolution.berkeley.edu/the-history-of-evolutionary-thought/1800s/early-concepts-of-evolution-jean-baptiste-lamarck/ Huxley, T.H. “Agnosticism.” K. Paul, Trench. London. 1889. https://archive.org/details/a622650700huxluoft/page/169/mode/1up Huxley, T.H. “Aphorisms and Reflections. From the Works of T. H. HUXLEY, Selected byHenrietta A. Huxley. Macmillan and Co. London. 1907. Accessed online: http://aleph0.clarku.edu/huxley/Book/Aphor.html Huxley, T.H. “Autobiography and Selected Essays.” Riverside College Classics. 1909. Accessed online: https://www.gutenberg.org/files/1315/1315-h/1315-h.htm#link2H_4_0007 Huxley, T.H. “Collected Essays, Volume V: Science and Christian Tradition.” https://www.gutenberg.org/files/15905/15905-h/15905-h.htm Huxley, T.H. “Evidence as to man's place in nature.” D. Appelton and Co. New York. 1863. https://archive.org/details/evidenceastomans00huxl/page/n1/mode/2up Huxley, T.H. “On Some Organisms Living at Great Depths in the North Atlantic Ocean.” Quarterly Journal of Microscopical Science. viii., new Series, 1868, pp. 203-212. http://aleph0.clarku.edu/huxley/SM3/bathy.html Huxley, T.H. “On the Relations of Man to the Lower Animals.” Project Gutenberg eBook. 2001. https://www.gutenberg.org/cache/epub/2932/pg2932-images.html Joshi RS. “The Inner Root Sheath and the Men Associated with it Eponymically.” Int J Trichology. 2011 Jan;3(1):57-62. https://pmc.ncbi.nlm.nih.gov/articles/PMC3129131/ Lamarck, Jean-Baptiste. “Zoological Philosophy.” Macmillan. London. 1914. https://archive.org/details/ZoologicalPhilosophy Lyons, Sherrie L. “Thomas Henry Huxley : the evolution of a scientist.” Prometheus Books. New York. 1999. McGraw, Donald J. “Bye-Bye Bathybius: The Rise and Fall of a Marine Myth.” Bios, vol. 45, no. 4, 1974, pp. 164–71. JSTOR, http://www.jstor.org/stable/4607257 “Nobel Prize in Physiology or Medicine 1963.” The Nobel Prize. https://www.nobelprize.org/prizes/medicine/1963/summary/ Pearce, JMS. “Thomas Henry Huxley.” Hektoen International. Sept. 18, 2020. https://hekint.org/2020/09/18/thomas-henry-huxley/ Schwartz, Joel S. “Darwin, Wallace, and Huxley, and ‘Vestiges of the Natural History of Creation.’” Journal of the History of Biology, vol. 23, no. 1, 1990, pp. 127–53. JSTOR, http://www.jstor.org/stable/4331120 “Thomas Henry Huxley.” Darwin Correspondence Project. University of Cambridge. https://www.darwinproject.ac.uk/thomas-henry-huxley “Thomas Henry Huxley (1825-1895).” Humanist Heritage. https://heritage.humanists.uk/thomas-henry-huxley/ Tunstad, Erik. “Darwin's Bulldog: Thomas Huxley 200 Years.” Prosa. July 10, 2025. https://prosa.no/artikler/aktuelt/darwins-bulldog-thomas-huxley-200-ar Wyhe, John van. “It ain't necessarily so ...” The Guardian. Feb 9, 2008. https://www.theguardian.com/science/2008/feb/09/darwin.myths See omnystudio.com/listener for privacy information.
A tiny molecule produced inside your body may play a major role in how well you circulate blood, manage inflammation, exercise, and age. In this episode of Sharkpreneur, Seth Greene interviews Nathan S. Bryan, Ph.D., Founder, Chairman, and CEO of Bryan Therapeutics, Inc., who explains nitric oxide's role in blood-vessel function, tissue oxygenation, inflammation, metabolism, and cellular energy, and shares his view on everyday habits that can affect the body's natural production. He also discusses the oral microbiome, dietary considerations, lifestyle practices, consumer education, and the research-based standards he believes people should use when evaluating nitric oxide-related products. Key Takeaways:→ Nitric oxide helps regulate blood flow, oxygen delivery, inflammation, metabolism, and cellular signaling. → Oral-care habits may affect the oral microbiome, which helps metabolize dietary nitrate.→ Green vegetables and beets may contain dietary nitrate.→ Product claims should be supported by scientific and clinical data. → Lifestyle habits influence nitric oxide production. Dr. Nathan S. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was the recipient of the Dean's Award for Excellence in Research. He pursued his postdoctoral training as a Kirschstein Fellow at Boston University School of Medicine's Whitaker Cardiovascular Institute. After a two-year post-doctoral fellowship, in 2006, Dr. Bryan was recruited to join the faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. Dr. Bryan has been involved in nitric oxide research for the past 25 years and has made many seminal discoveries in the field, has dozens of issued patents, and has published more than 100 peer-reviewed scientific articles in some of the top science and medical journals. Dr. Bryan is a best-selling author and successful entrepreneur who has built a billion-dollar enterprise value portfolio of companies. Dr. Bryan is one of the most successful inventors and top revenue producers in the history of the University of Texas Health Sciences Center at Houston. He is currently the Founder, Chairman, and CEO of Bryan Therapeutics, Inc., a privately held, clinical-stage biotechnology company actively engaged in the discovery and development of nitric oxide-based therapies. BTI has active drug development programs in heart disease, Alzheimers' Disease, and topical drugs for diabetic ulcers and non-healing wounds. Dr. Bryan's consumer line of nitric oxide products is among the most innovative and successful on the market. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Connect With Nathan:Website: https://n1o1.com/https://bryantherapeutics.com/ Instagram: https://www.instagram.com/drnathansbryan X: https://x.com/drnitric LinkedIn: https://www.linkedin.com/in/drnathansbryan/ YouTube: https://www.youtube.com/@drnathansbryannitricoxide
Send us Fan MailPut the Phone Away: Walk With IntentionWe all know walking is good for our health—but how you walk matters, too.In this Lifestyle MD Soundbite, Dr. Angela explores why walking is most beneficial when you're fully present rather than distracted by your phone. Looking down at a screen changes your posture, slows your pace, and disconnects you from the environment around you. Research suggests that walking while focused on a smartphone may reduce some of the mental and emotional benefits of walking, including improvements in mood and connectedness with nature, while also altering normal walking mechanics. (mdpi.com)Dr. Angela challenges listeners to try their next walk with their phone tucked away, notifications silenced, and their attention focused on the sights, sounds, and sensations around them. (Yes—even if you're listening to this podcast!)Timestamps00:00 Why Walking Matters00:31 How Your Phone Changes Your Walk01:07 What the Research Shows01:34 Dr. Angela's Walking Challenge01:58 Embracing a Tech-Free Walk02:06 The Ironic Podcast Reminder02:19 Closing ThoughtsKey TakeawaysWalking is one of the simplest, most effective ways to improve physical and mental health.Using a smartphone while walking encourages a slower pace, poorer posture, and changes in normal gait mechanics. (frontiersin.org)Being fully present during a walk—especially outdoors—can enhance mood, reduce negative emotions, and increase feelings of connection with nature. (mdpi.com)Putting your phone away for even one walk each day is a simple habit that can help you get more from your movement.Stay Connected
Dr. Caroline Rickards is a Professor in the Department of Physiology and Anatomy at the University of North Texas Health Science Center in Fort Worth. In this episode, she discusses how anti-doping researchers can better communicate the work to various audiences. We cover common science communication challenges, strategies for improving science communication skills, how scientists can prepare themselves to take advantage of research dissemination opportunities, and the changing landscape of science communication.
What if the greatest shift you could make in your practice wasn't learning a new technique... but changing the way you think about health itself? In this episode, Dr. Fred explores the foundational philosophy that has guided his decades in chiropractic: health isn't something that's given to us, it's something the body is designed to express when interference is removed. From innate intelligence and nervous system function to the importance of vision, mission, and purpose, he challenges chiropractors to move beyond symptom-focused care and return to the true principles of the profession. Throughout the conversation, he emphasizes that chiropractic isn't about treating disease, it's about restoring the body's internal resistance and optimizing function. You'll also hear practical insights on communicating chiropractic more effectively, creating better patient experiences, building a philosophy-driven practice, and why today's world needs chiropractors more than ever. In this episode you'll hear about: Why every chiropractor needs a clear vision, mission, and purpose The difference between restoring function and treating disease How the nervous system influences every aspect of health Why optimizing function leads to better patient outcomes The concept of allostasis and adapting to today's constant stressors Why health is multidimensional and requires more than one solution Practical ways to communicate chiropractic philosophy to patients Why serving patients, not chasing numbers, is what builds a thriving practice The importance of creating habits that support long-term health and success Because when you stop chasing symptoms and start maximizing function, you help people unlock the health they were designed to have. "Health is a natural condition of the body. Our job is to locate the interference and restore function." – Dr. Fred Weekly Action Challenge This week, take a closer look at how you're communicating the value of chiropractic. Are you talking primarily about pain... or about function? Are your patients leaving with a deeper understanding of why they're under care? Choose one opportunity this week to shift the conversation beyond symptoms and toward helping someone understand the incredible potential of the human body. Some ideas: Explain how chiropractic supports function, not just pain relief. Review your office's vision, mission, and purpose with your team. Evaluate one patient interaction and ask, "Did I educate or simply adjust?" Identify one daily habit that improves your own physiology—whether it's movement, nutrition, rest, or stress management. Ask yourself each morning: "Am I helping people express better health, or simply chasing symptoms?" The strongest practices are built on strong philosophy. Keep Charging! MoChihChu! Ask a Question for a Future Episode! Apply to work with our coaches! Join Susan's monthly CA webinars Join us at our next seminars! Join the Rhino Digital Training!
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80% of Americans are metabolically unhealthy, which means the obesity conversation isn't about weight for a lot of people... It's about internal health markers that indicate a declining state of metabolic function regardless of what someone weighs. Inside today's episode, I get into the harder version of the obesity conversation including whether it should be classified as a chronic medical condition, what happens when we label people as broken and then sell them the solution to their "brokenness", and where the personal responsibility conversation sits in a landscape flooded with GLP-1 medications and food environments engineered to defeat every mechanism the body has for satiety.Topics discussed: - The 80% Metabolically Unhealthy Statistic- Obesity as a Chronic Medical Condition- The Broken Mindset Trap- Personal Responsibility and Empowerment- Cardiovascular Risk, Longevity, and Children- Practices, Perceptions, and Physiology- Generational Parenting and Food Culture- The Chronic Dieting Flip Side---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscienceYoutube: SamMillerScience Facebook: The Nutrition Coaching Collaborative CommunityTikTok: @sammillerscience----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
In this episode, we review the high-yield topic of Parathyroid physiology from the Endocrine section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Robbie Deckard is a professional middle-distance triathlete and triathlon coach, and the founder of Freaky Fast Aero Accessories. In this episode, Robbie and Mikael dig into the real differences between American and European training methods, using lactate and VLaMax to optimise training and performance, and how age-group triathletes can apply lab-grade thinking to swim, bike and run training without actually going into a lab. HIGHLIGHTS AND KEY TOPICS: The real difference between FTP-centric American coaching and the German/Benelux style built around VLaMax, VO2max and physiological profiling. The evolution of VLaMax based training: from Alois Mader's 1970s model through Jan Olbrecht to current day coaches like Dan Lorang. Robbie's case for still doing dedicated VO2max work, including a case study that took an amateur cyclist's VO2max from 74 to 87 mL/kg/min over 58 weeks of block periodisation. Why building maximal aerobic power early is more valuable long-term than chasing threshold gains, and how that shapes the "durability" that separates junior and U23 cyclists from senior professional cyclists. How Robbie profiles athletes using LT1, LT2 and 5-minute power (or 500 yd swim time, or mile run time), and what typical percentage utilisation looks like for age-groupers versus elites. How he prescribes endurance, threshold and VO2max sessions in practice, including cues (power, pace, RPE), lactate targets, and why exact wattage precision on threshold work matters less than people think. Practical advice for age-groupers: open-water swim skills and ankle-band drills, running road races for pacing and durability, and hill running for strength and economy. Improving aerodynamics on a budget: reduce frontal area first, then refine airflow, and how to measure progress without a wind tunnel using Golden Cheetah or a simple speed sensor. SHOWNOTES, LINKS, RESOURCES AND RELATED EPISODES: Follow Robbie Deckard and Freaky Fast Aero Accessories on his website, blog, Instagram, and Freaky Fast Aero Accessories' Instagram. The shownotes for today's episode can be found here. The full podcast episode archives (including category filters) can be found here. A Scientific Approach to Improve Physiological Capacity of an Elite Cyclist - Rønnestad & Hansen 2018 FTP, VO2max and VLaMax with Sebastian Weber | EP#169 VLaMax, Polarised training, Fatigue and Complexity with Mark Burnley, PhD | EP#331 Training talk with Sebastian Zeller | EP#259 Training structure, periodisation and the science of winning with Jan Olbrecht, PhD | EP#198 Training, testing, metabolism and physiology with Björn Kafka | EP#286 Kolie Moore – Overrated and Underrated Factors for Cycling Performance The Science of Winning: Planning, Periodizing and Optimizing Swim Training - book by Jan Olbrecht The Triathlete's Training Bible - book by Joe Friel Software mentioned: Aerotune, Golden Cheetah, INSCYD, Sentiero SPONSORS: Precision Fuel & Hydration produce our favourite gels, sports drinks, and electrolyte and carbohydrate products here at That Triathlon Show and Scientific Triathlon. Use the free Fuel & Hydration Planner to get a personalised plan for your carbohydrate, sodium and fluid intake in your next event, and get 15% off your first 2026 order by using the code TTS2026 at checkout. Rouvy is hands down the most complete indoor cycling platform for triathletes. Among their thousands of beautiful bike courses from all around the world, all filmed in stunning quality, they have over 75 IRONMAN and IRONMAN 70.3 race courses plus 20+ Challenge Family courses, so you can pre-ride your race from home. Real gradients, real visuals, and real feel! Head to rouvy.com and use the code TTS to get your first month free on top of a 7-day free trial. Effortless Swimming produce the best swim goggles for triathletes and open water swimmers. Their NanoClear anti-fog lenses give you clear, fog-free vision that lasts and doesn't wear off. Don't let foggy or leaky goggles ruin another swim. Go to shop.effortlessswimming.com and use the code TTS15 to get 15% off your goggles, and get a free two-month Effortless Swimming course membership. ZenAI is the next frontier of podcasting. It lets you turn your ideas into a podcast without any knowledge of audio editing, video, or production. You do the talking, and the AI handles the production, editing, clipping, and the rest, and you can direct your AI producer in plain English. You can even record from your phone, so no expensive studio gear is needed to sound great. ZenAI is a new product from Zencastr, a platform I've been a paying customer of for over nine years here at That Triathlon Show. ZenAI is currently in invite-only beta. Join the waitlist today here.LEARN MORE ABOUT SCIENTIFIC TRIATHLON: The Scientific Triathlon website is the home of That Triathlon Show and everything else that we doContact us through our contact form or email me directly (note - email/contact form messages get responded to much more quickly than Instagram DMs)Subscribe to our NewsletterFollow us on InstagramLearn more about our coaching, training plans, and training camps. We have something to offer for everybody from beginners to professionals.HOW CAN I SUPPORT THAT TRIATHLON SHOW (FOR FREE)? I really appreciate you reading this and considering helping the show! If you love the show and want to support it to help ensure it sticks around, there are a few very simple things you can do, at no cost other than a minute of your time. Subscribe to the podcast in your podcast app to automatically get all new episodes as they are released.Tell your friends, internet and social media friends, acquaintances and triathlon frenemies about the podcast. Word of mouth is the best way to grow the podcast by far!Rate and review the podcast (ideally five stars of course!) in your podcast app of choice (Spotify and Apple Podcasts are the biggest and most important ones).Share episodes online and on social media. Share your favourite episodes in your Instagram stories, start a discussion about interesting episodes on forums, reference them in your blog or Substack. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Patience, persistence and a strong will for never giving up. Discovering how the immune system is kept in check demanded a lot of our 2025 medicine laureates. Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi spent years finding out how our body's powerful immune system is regulated – leading to the development of medical treatments for cancer and autoimmune diseases. Join us for our conversation where we unravel the achievements behind the 2025 Nobel Prize in Physiology or Medicine. For a quick introduction to 2025's awarded discovery in physiology or medicine, check out our Crash Course on regulatory T-cells or Olle Kämpe's eloquent speech from the Nobel Prize award ceremony.Read complete profiles of Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi, and explore the 2025 Nobel Prize in Physiology or Medicine at our website, nobelprize.org.See the announcement of the Nobel Prize in Physiology or Medicine 2025 and the moment Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi were awarded their medals, all available on YouTube.This podcast was a production of Nobel Prize Outreach and Filt, and created in cooperation with Fundación Ramón Areces. Hosted on Acast. See acast.com/privacy for more information.
Think a pulse oximeter reading of 100% means your patient is getting enough oxygen? Think again. In this episode of 10 Minute Medic, we'll uncover one of the biggest misconceptions in paramedic education by breaking down the oxygen-hemoglobin dissociation curve in a way that finally makes sense. Using memorable analogies, real EMS scenarios, and practical field applications, you'll learn why oxygen sometimes refuses to leave hemoglobin, why a "normal" SpO₂ can hide life-threatening illness, and what carbon monoxide, cyanide, hypothermia, and sepsis all have in common. If you've ever memorized "left shift" and "right shift" without truly understanding them, this episode will change the way you think about oxygen delivery—and make you a better clinician on your very next call. FREE STUDY GUIDE DISSOCIATION CURVE
Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzThis week on the podcast Mikki speaks to two researchers, Professor Daniela Hurtado and Dr Regina Castaneda about the interaction between HRT and tirzepatide use. In a conversation led by Regina, they talk about differences that occur as women head through menopause, the role of HRT at mitigating some of these changes and the findings from their paper looking at how hormone therapy might enhance the therapeutic effects of tirzepatide in a postmenopausal population - discussing sex related differences.Maria Daniela Hurtado Andrade, M.D., Ph.D., is from Ecuador where she completed her medical degree at the Pontifical Catholic University. Her curiosity about the causes of obesity led her to pursue doctorate-level training in Physiology and Pharmacology at the University of Florida. Her research focused on the brain's regulation of food intake. After her doctoral training, she completed Internal Medicine training at the University of Pittsburgh Medical Center in Pittsburgh, PA, and Endocrinology Fellowship specialty training at Mayo Clinic in Rochester, MN. She joined Mayo Clinic Staff in 2019.Dr. Hurtado Andrade is interested in understanding obesity's pathophysiology to develop more effective therapeutic interventions. She is part of the Mayo Clinic Precision Medicine for Obesity program. This program aims at developing an individualized approach to the management of obesity and its complications with the goal of improving outcomes. To facilitate the generation of this new knowledge, she has focused her clinical and research efforts on specific populations: perimenopausal women and breast cancer survivors. Dr. Hurtado's contributions and expertise to the field of obesity have been recognized nationally and internationally.Regina Castaneda, MD, serves as a postdoctoral research fellow at Mayo Clinic in Florida. She is also an MSc candidate at Mayo Clinic College of Medicine and Science. Her work centres on women's health topics including obesity, diabetes, and menopause-related metabolic changes.Dr Castaneda has contributed to research examining the effects of tirzepatide on weight loss in postmenopausal women and the potential influence of hormone therapy. She is affiliated with the Division of Endocrinology, Diabetes and Metabolism at Mayo Clinichttps://www.mayoclinic.org/biographies/hurtado-andrade-maria-daniela-m-d-ph-d/bio-20539671https://www.linkedin.com/in/regina-castaneda-md-8b2371358/ Paper: https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(25)00145-1/abstract Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
Send us Fan MailHow far has delivery room ventilation really come? In this special episode, recorded in collaboration with the Neonatal Resuscitation Symposium, Ben sits down with Dr. Charles Roehr, professor of neonatology and perinatal medicine at the University of Bristol, clinical trialist at the University of Oxford, and member of ILCOR. Together they trace the evolution of respiratory support at birth, from the era of fixed inflation breaths to today's focus on physiologic stability and gentle cardiopulmonary transition. Dr. Roehr reflects on a quarter century of resuscitation science, the enduring challenge of human factors in the delivery room, and where the field may be heading, from better intrapartum monitoring to increasingly specialized resuscitation teams.Dr. Roehr will be delivering a keynote, "Optimizing Effective Ventilation Strategies in the Delivery Room," at the Neonatal Resuscitation Symposium, taking place September 10 to 11 at Indiana University in Indianapolis. Learn more and register here: https://medicine.iu.edu/pediatrics/specialties/neonatal-perinatal/education/resuscitation-symposium Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
One of Sheldon's funniest one-liners is that multivitamins are nothing more than “expensive urine.” Is that just sitcom sarcasm, or is there real science behind the joke? In this episode, we dive into nutrition research, learn when vitamins actually help, and discover why the answer is much more interesting than a simple yes or no.
Join us as we explore the latest insights in yoga anatomy, injury prevention, aging, and the impact of language on body perception with Dr. Andrew McGonigle a medically trained yoga expert. Discover practical principles, debunk myths, and learn how to approach body health with confidence. Main Topics: · Yoga anatomy principles · Myths about fascia and muscle lengthening · The role of the nervous system in flexibility · How aging affects mobility and strength · Language and body perception in yogConnect with Andrew Upcoming in person trainings: https://www.doctor-yogi.com/in-person-events Weekly Yoga Anatomy Insights newsletter: https://doctoryogi.substack.com Andrew McGonagall's Website - https://andrewmcg.com Physiology of Yoga (Book) - https://www.amazon.com/dp/B07XYZ1234 Common Injuries of Yoga (Book) - https://www.amazon.com/dp/B07XYZ5678 Andrew McGonagall's Online Courses - https://andrewmcg.com/courses Website - https://andrewmcg.com Instagram - https://instagram.com/andrewmcg SUPPORT KEEN ON YOGA Become a Patron: https://www.keenonyoga.com/patrons/ Buy us a coffee: https://www.buymeacoffee.com/infoRf FULL PODCAST LIST https://www.keenonyoga.com/keen-on-yoga-podcast-guests/ CONNECT WITH ADAM https://linktr.ee/Keenonyoga WATCH: https://www.youtube.com/@keenonyoga
Dr. Diana Walsh Pasulka — professor of religious studies, author of The Others: UFOs, AI, and the Secret Forces Guiding Human Destiny — is here to answer one of the most controversial and fascinating questions of our time: what if many of humanity's oldest spiritual encounters weren't interpreted correctly at all?Dr. Pasulka breaks down:- Shocking similarities between alien abductions & purgatory that first pulled her into UAP research- Whether historical Catholic supernatural experiences would be interpreted today as UFO encounters- Why many researchers believe we need to radically rethink the concept of “aliens”- Physiology of UAP encounters and how experiencers may access altered states or different parts of the brain- Carl Jung's theory that UFOs could emerge from the unconscious mind- Why belief in nonhuman intelligence is rapidly increasing, and why it may function as a modern religion- Reports throughout Catholic history describing encounters with nonhuman entities- Whether aerospace engineers and scientists are receiving “downloads” or ideas from nonhuman intelligence- Recent deaths and disappearances of scientists connected to nuclear and aerospace programs (Are they connected to UAP research?)- Why proof of nonhuman intelligence may NOT destroy religious belief- Why some people believe AI could be the antichrist, while others think resisting AI is the true danger- Whether governments are in a position to confirm historical religious events- Psychedelics, altered states, and historical encounters with nonhuman intelligence- Why certain people appear far more open to supernatural experiences than others- Hidden role sci-fi plays as a framework for understanding modern UFO phenomena- Real function of religion and how humanity uses belief systems to explain what science still can't- Measurable physical & neurological benefits of prayer- Whether humanity is heading toward a religious revival, or if religion has become too politicized to recoverThis episode of Mayim Bialik's Breakdown explores the intersection of UFOs, religion, consciousness, AI, mysticism, Catholicism, neuroscience, psychedelics, government secrecy, and the future of human belief itself.If you're interested in UAP disclosure, nonhuman intelligence, ancient religions, consciousness research, alien encounters, spiritual experiences, or the future of AI, this conversation will challenge everything you think you know!Pre-Order Dr. Diana Walsh Pasulka's new book, THE OTHERS: UFOs, AI, and the Secret Forces Guiding Human Destiny, out July 28th: https://us.macmillan.com/books/9781250394866/theothers/Follow us on Substack for Exclusive Bonus Content: https://bialikbreakdown.substack.com/BialikBreakdown.comYouTube.com/mayimbialikSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
On this episode of Vitality Radio, Jared explores an often-overlooked obstacle to better health: becoming so focused on wellness that fear begins to work against healing. Learn how chronic stress, health anxiety, information overload, and perfectionism can affect digestion, inflammation, the nervous system, and your overall sense of well-being. Jared explains why awareness should lead to calm, practical action rather than worry, and how your mindset can influence the way your body responds to everyday challenges. Through personal stories, scientific research, and practical strategies, you'll discover how to pursue better health without becoming consumed by it. If you've ever felt overwhelmed by lab results, toxins, symptoms, or conflicting health advice, this episode offers a healthier perspective on building resilience, confidence, and true vitality. Visit the podcast website here: VitalityRadio.comYou can follow on Instagram https://www.instagram.com/vitalitynutritionbountiful/ and https://www.instagram.com/vitalityradio/, or on Facebook https://www.facebook.com/vitalityradio and https://www.facebook.com/MyVitality. Join us also in our Facebook group https://www.facebook.com/MyVitality . Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.comhttps://drtalks.com/podcast-service/
Dr. Diana Walsh Pasulka — professor of religious studies, author of The Others: UFOs, AI, and the Secret Forces Guiding Human Destiny — is here to answer one of the most controversial and fascinating questions of our time: what if many of humanity's oldest spiritual encounters weren't interpreted correctly at all?Dr. Pasulka breaks down:- Shocking similarities between alien abductions & purgatory that first pulled her into UAP research- Whether historical Catholic supernatural experiences would be interpreted today as UFO encounters- Why many researchers believe we need to radically rethink the concept of “aliens”- Physiology of UAP encounters and how experiencers may access altered states or different parts of the brain- Carl Jung's theory that UFOs could emerge from the unconscious mind- Why belief in nonhuman intelligence is rapidly increasing, and why it may function as a modern religion- Reports throughout Catholic history describing encounters with nonhuman entities- Whether aerospace engineers and scientists are receiving “downloads” or ideas from nonhuman intelligence- Recent deaths and disappearances of scientists connected to nuclear and aerospace programs (Are they connected to UAP research?)- Why proof of nonhuman intelligence may NOT destroy religious belief- Why some people believe AI could be the antichrist, while others think resisting AI is the true danger- Whether governments are in a position to confirm historical religious events- Psychedelics, altered states, and historical encounters with nonhuman intelligence- Why certain people appear far more open to supernatural experiences than others- Hidden role sci-fi plays as a framework for understanding modern UFO phenomena- Real function of religion and how humanity uses belief systems to explain what science still can't- Measurable physical & neurological benefits of prayer- Whether humanity is heading toward a religious revival, or if religion has become too politicized to recoverThis episode of Mayim Bialik's Breakdown explores the intersection of UFOs, religion, consciousness, AI, mysticism, Catholicism, neuroscience, psychedelics, government secrecy, and the future of human belief itself.If you're interested in UAP disclosure, nonhuman intelligence, ancient religions, consciousness research, alien encounters, spiritual experiences, or the future of AI, this conversation will challenge everything you think you know!Go to https://surfshark.com/mayim or use code MAYIM at checkout to get 4 extra months of Surfshark VPN!Start your new morning ritual & get up to 43% off your @MUDWTR with code BREAK at https://www.mudwtr.com/BREAK ! #mudwtrpodFFRF: If that matters to you, go to http://FFRF.US/BREAKDOWN or text, “BREAKDOWN” to 511511 to learn more and join.For a limited time, get $250 off Cove Pure water filtration at http://www.covepure.com/breakdownGet the Discounted Early Bird registration to the IANDS Annual conference before the sale ends July 15. Visit https://conference.iands.orgMake your summer wardrobe feel easier. Go to https://www.quince.com/breakdown for free shipping on your order and 365-day returns.Pre-Order Dr. Diana Walsh Pasulka's new book, THE OTHERS: UFOs, AI, and the Secret Forces Guiding Human Destiny, out July 28th: https://us.macmillan.com/books/9781250394866/theothers/Follow us on Substack for Exclusive Bonus Content: https://bialikbreakdown.substack.com/BialikBreakdown.comYouTube.com/mayimbialikSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Learn how the heat impacts performance for the CrossFit athlete.» Hire a Coach: https://www.zoarfitness.com/coach/» Free Educational Content: https://zoarfitness.com/articles» Shop Programs: https://www.zoarfitness.com/product-category/downloads/» Follow ZOAR Fitness on Instagram: https://www.instagram.com/zoarfitness/Support the show
Did evolution really make women more sensitive to high-pitched sounds so they'll wake up when a baby cries? In this episode, we separate a clever sitcom one-liner from decades of research in evolutionary psychology, neuroscience, and parenting. The answer is more fascinating—and much more nuanced—than the television version.
Welcome to the first episode of the Coach's Corner Series! This is a special series where I'm sitting down with the incredible functional health coaches and practitioners from the Vital Spark Coaching team to dive deeper into some of the topics we help clients navigate every day. One of the things I love most about our team is that each coach brings their own unique experiences, expertise, and perspective to supporting women through real-life struggles with hormones, metabolism, gut health, energy, body composition, and so much more. These conversations are designed to bring you behind the scenes and give you access to the knowledge, insights, and practical strategies they use with clients every day. Today I'm joined by Jodi Stonehocker and we are going to be talking all things mind body connection. If this is a new area of you, you're really going to enjoy this episode we believe because it's going to connect a lot of dots that a lot of traditional medicine doesn't. We'll also be discussing how mindset affects the body and physiology, the role of hyper vigilance, and where to start with mind body coaching. Time Stamps: (2:22) What Mind Body Coaching Really Is (6:32) How Mindset Affects The Body and Physiology (18:10) Hyper Vigilance (21:52) Supplements, Medication, and Peptides (24:27) Where To Start (28:12) Loving Yourself For Who You Are --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation. --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!
Marina Better is a PhD candidate in Physiology, Pharmacology, and Therapeutics (formerly Pharmacology and Molecular Sciences) at Johns Hopkins University whose research focuses on maternal-fetal health, drug delivery, and translational therapeutics for pregnancy-related conditions. Her work explores innovative nanomedicine and drug delivery approaches to improve outcomes in preterm birth and reproductive health. Originally from Fayetteville, Marina began her scientific journey as an NIH-RISE and NSF-PrOMiSS scholar at Fayetteville State University before continuing her training at Johns Hopkins. She has authored multiple peer-reviewed publications, presented her research nationally and internationally, and is deeply committed to mentorship, scientific equity, and expanding opportunities for underrepresented students in biomedical research. The long-term goal of Marina's work is to improve maternal and fetal health through interdisciplinary research and innovation.linkedin.com/in/marina-better-10935b14b?utm_source=share_via&utm_content=profile&utm_medium=member_iosPresented to you by The No Static Network!
Alcohol might be the most misunderstood topic in all of fitness.On one side, you have people who will tell you that a single drink torches your progress. That one night out shuts off fat loss, kills your gains, and undoes a week of hard work. On the other side, you have people who insist that calories are all that matter, so you can drink whatever you want as long as it fits your macros.Here's the reality. Both of those are oversimplifications, and the truth lives in a much more nuanced middle.Because the way alcohol actually affects your body composition has very little to do with some magical fat-storing property, and almost everything to do with the calories it contributes, what it does to your appetite and restraint, how it impacts your sleep, and the behaviors that tend to come along with a night of drinking. Separate the physiology from the behavior, and the entire conversation changes.In this episode, I'm joined by my good friend Dr. Mikki Williden, host of the Mikkipedia podcast, who holds a masters in human nutrition and a PhD in public health. Together we break down what the science actually says about alcohol, fat loss, and body composition. HERE'S WHAT WE COVER: WHY ALCOHOL IS THE MOST MISUNDERSTOOD TOPIC IN FITNESS & THE TWO EXTREMES TO AVOID HOW ALCOHOL IS METABOLIZED & WHY THE BODY TREATS IT AS A PRIORITY FUELWHY ALCOHOL TEMPORARILY SUPPRESSES FAT OXIDATIONTHE THREE MECHANISMS THROUGH WHICH ALCOHOL MAKES FAT LOSS HARDER HOW QUICKLY ALCOHOL CALORIES ADD UP & ERASE A WEEK'S WORTH OF DEFICIT WHY POOR SLEEP AFTER DRINKING DRIVES UP HUNGER & LOWERS RESTRAINT THE NEXT DAY WHAT THE RESEARCH SAYS ABOUT HABITUAL DRINKING & BODY WEIGHTWHY WINE LOOKS “HEALTHIER” THAN BEER & WHAT'S REALLY GOING ON WHY LIQUID CALORIES & ALCOHOL LEAD TO INCOMPLETE DIETARY COMPENSATION THE PRACTICAL PLAYBOOK FOR BUDGETING ALCOHOL INTO A FAT LOSS PHASE WHAT TO DO BEFORE, DURING & THE DAY AFTER DRINKING TO PROTECT YOUR PROGRESS WHERE TO CONNECT WITH DR. MIKKI WILLIDEN:https://www.instagram.com/mikkiwillidenWHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/For Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryEmail: Bdacruzfitness@gmail.comMy Reading Recommendations:THE MUSCLE & STRENGTH PYRAMIDS https://getdpd.com/cart/hoplink/25469?referrer=1l54og96lf1ccw
Could a stair that's only two millimeters taller than the rest actually make someone fall? In this episode, we explore the surprising science of how your brain learns patterns while walking and why even tiny changes in stair height can throw off your stride. It's a fun look at biomechanics, psychology, and engineering that proves reality is sometimes stranger than sitcoms. Was Sheldon Right?, the podcast where we separate sitcom science from scientific fact.
(A note before we get into it: this article is educational, not medical advice. Talk to your doctor or a registered dietitian before making major changes to your diet — especially if you have diabetes or pre-diabetes, take blood-sugar medication, are pregnant or nursing, or are managing any chronic condition. Nothing here is intended to diagnose, treat, cure, or prevent any disease.)Research shows well-built plant-based diets usually lower blood sugar. If yours moved the other way, one of six silent glucose traps is almost always the reason — and every one of them is fixable.TLDR* The research is actually on vegetarianism's side. Large reviews of clinical trials show vegetarian and vegan diets tend to lower A1C, not raise it.* So if your numbers went up, something in how the diet was built is the real cause — not the fact that it's plant-based.* Six usual suspects: too little protein, “naked” carbs with no brakes, shrinking muscle mass, too much fermentable fiber too fast, high stress/cortisol, and late-night eating.* Each one is a fixable habit, not a reason to abandon vegetarianism.Wait — Doesn't “Plant-Based” Mean Healthier Blood Sugar?Usually, yes. When researchers actually put vegetarian diets to the test in clinical trials, the pattern is consistent: people following them tend to see their A1C go down, not up. A meta-analysis pooling multiple randomized trials found vegetarian diets were linked to a meaningful drop in A1C, and a separate meta-analysis of nine trials found a similar reduction — enough that it would be considered clinically significant by the FDA's own bar for new diabetes drugs.So if you switched to vegetarian eating and your last lab draw came back worse, I want to be straight with you: that's not the expected outcome, and it's not “just what happens” when you cut out meat. Something specific is working against you. The good news is that it's almost always one of a handful of well-understood mechanisms — and once you know which one, it's a quick fix, not a diet overhaul.Think of it like this: a car engine doesn't run worse because you switched to a different brand of gas. It runs worse because something specific — a clogged filter, bad timing, low oil — is getting in the way. Same idea here. Let's go through the six most common “clogs.”THRIVE 120 - TriplePlayDoc is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.1. The Protein Drop You Didn't NoticeThis is the single most common one. When people cut out meat, they usually don't replace that protein gram-for-gram with plant protein — they replace it with more carbs, because carbs are what fill the plate: extra rice, extra bread, extra pasta.Here's why that matters for blood sugar specifically. Protein eaten alongside carbohydrate isn't just “extra food” — it changes how your body handles the carbs. A meta-analysis of controlled feeding trials found that adding protein to a carb-containing meal meaningfully lowers the post-meal glucose spike, largely by boosting the insulin response that clears sugar out of the bloodstream faster. Pull protein out of the meal and carbs hit your blood essentially unguarded.Think of protein as the brakes on a sugar rollercoaster. Take the brakes off, and the same carbs you were eating before now send your blood sugar higher and faster than they used to.2. Naked Carbs, No BrakesThis is the same problem from a different angle: oatmeal for breakfast, a rice bowl for lunch, a smoothie for a snack. All reasonable foods — but if none of them are paired with enough protein or fat, and you're not about to go move that sugar with a workout, it hits your bloodstream as a fast, unbuffered spike. Your body answers with a bigger insulin surge, and doing that meal after meal, day after day, is exactly the pattern linked to declining insulin sensitivity over time.3. The Muscle FactorThis one surprises people: your muscles are the biggest “storage tank” for the sugar you eat. After a meal, skeletal muscle soaks up roughly 70–80% of the glucose that comes out of your bloodstream, using it to refill glycogen stores. Researchers who study this consider muscle glucose uptake the single biggest lever on whole-body insulin sensitivity.So when protein intake drops and resistance training isn't part of the picture, muscle mass tends to shrink over time — and that storage tank gets smaller. Less tank space means the same meal now leaves more sugar circulating in your blood for longer, which shows up as a slow, creeping rise in A1C.Muscle is basically your body's biggest gas tank for sugar. Shrink the tank, and the same fill-up overflows.4. High Fiber, High StressFiber itself is not the villain here — in fact, the right kind of fiber is one of the best tools for blood sugar control. Viscous, soluble fibers (found in oats, beans, and psyllium) form a gel in your gut that physically slows down how fast sugar gets absorbed, and trials show this type of fiber measurably lowers both A1C and fasting blood sugar.The issue is a different kind of fiber problem: volume and speed. Vegetarian diets are often naturally high in fermentable fiber — beans, lentils, certain grains — and when your gut bacteria break that fiber down, the fermentation process produces gas as a byproduct. Ramp up fiber intake quickly, especially the fast-fermenting kinds, and you can outpace your gut's ability to comfortably process it, leading to bloating and discomfort. That physical stress on your body, especially combined with everyday life stress, triggers cortisol release — and cortisol has a direct, well-documented job of raising blood glucose by signaling your liver to make more sugar and by making your cells less responsive to insulin.Think of fiber fermentation like a construction project in your gut. The building itself (your microbiome) benefits — but a project moving too fast kicks up a lot of dust (gas and bloating) along the way.5. Timing and Circadian RhythmsThe lifestyle shift that often comes with going vegetarian — more grazing, more small meals, more snacking — can quietly push more of your eating into the evening. That timing matters more than most people realize. Multiple studies using identical meals given at different times of day have found that the exact same meal produces a bigger blood sugar spike at night than it does in the morning, because your insulin sensitivity and beta-cell function both naturally dip in the evening. One study even found a late meal after 8pm was independently linked to worse A1C.Your body runs on a work shift for carbs. The day shift (morning, early afternoon) handles them efficiently. The night shift is running on a skeleton crew — the same carb load left unprocessed for longer, working against you while you sleep.6. Cortisol: The Common ThreadYou'll notice cortisol keeps coming up — that's not a coincidence. Cortisol's actual job during stress is to make more glucose available fast, by triggering your liver to produce it and by directly blunting how well your cells respond to insulin. Whether the stressor is emotional (a hard week at work) or physical (a gut that's working overtime to ferment more fiber than it's used to, or a body that's lost muscle mass and is struggling to regulate blood sugar as efficiently), the hormonal response is the same: more sugar released, less efficiently cleared.Who's Most Likely to Notice This?Not everyone who goes vegetarian sees their A1C move. The people most likely to notice these effects are those who already have some combination of insulin resistance, chronic stress, poor sleep, low muscle mass, or a sensitive gut. For them, a vegetarian diet doesn't cause the problem — it tends to reveal a metabolic bottleneck that was already there, quietly, underneath a different diet.This isn't a case against vegetarian eating. The clinical research is genuinely favorable toward it. It's a case for building it correctly — with enough protein, the right kind and pace of fiber, resistance training to protect muscle, and carbs eaten earlier in the day, paired with something that slows them down.Six Bottlenecks at a GlanceThe Bottom LineThe question was never really “is vegetarianism good or bad for blood sugar?” — the research says it's generally good when it's built well. The real question is: what's your body's current metabolic bottleneck? Is it protein? Muscle? Fiber pacing? Timing? Stress? Most people are dealing with one or two of these more than the others, and once you know which, the fix is usually a small, specific adjustment — not throwing out the diet.The goal isn't just to tweak what's on your plate. It's to find the actual thing standing between you and the results you were expecting when you made this change in the first place.References* Vegetarian and Vegan Dietary Patterns to Treat Adult Type 2 Diabetes: A Systematic Review and Meta-Analysis of RCTs — ScienceDirect: https://www.sciencedirect.com/science/article/pii/S2161831324001285* Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis — PubMed: https://pubmed.ncbi.nlm.nih.gov/25414824/* The Effect of Adding Protein to a Carbohydrate Meal on Postprandial Glucose and Insulin Responses: A Systematic Review and Meta-Analysis — ScienceDirect: https://www.sciencedirect.com/science/article/pii/S0022316624003924* The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise — Frontiers in Physiology: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2011.00112/full* Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise — MDPI/Nutrients: https://www.mdpi.com/2072-6643/14/3/647* Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with T2DM: systematic review and meta-analysis — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500602/* Dietary fiber in irritable bowel syndrome (fermentation and gas production) — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5548066/* Fibre, fermentation, FODMAPs and flatulence — Quadram Institute: https://quadram.ac.uk/blogs/fibre-fermentation-fodmaps-and-flatulence/* Physiology, Cortisol — StatPearls, NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK538239/* Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans — PNAS: https://www.pnas.org/doi/10.1073/pnas.1418955112* Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes — Diabetologia/PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7002226/* Chronotype, Chrononutrition and Glucose Tolerance Among Prediabetic Individuals (late-dinner/A1C link): https://cdn.clinicaltrials.gov/large-docs/64/NCT05163964/Prot_SAP_ICF_004.pdfTHRIVE 120 - TriplePlayDoc is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe
A research roundup episode, where Dr. Gabriele Gallo (of KnowledgeIsWatt) and myself cover four recent research papers and how they might help us train better and improve our understanding of triathlon and endurance performance HIGHLIGHTS AND KEY TOPICS: Do the same training program twice - get different results? (and how Gabriele and I disagree slightly on the conclusions to draw from this study) Strength training is beneficial for cycling performance, but how beneficial is it really? And is it beneficial for everybody? Finally, how should you structure your strength training program to make it so? A massive review on the impact of different types of endurance training on mitochondrial and capillary growth, and VO2max improvements. What separates athletes of different performance levels is not how high they can push their threshold as a percentage of VO2max, but how high the VO2max is in the first place. SHOWNOTES, LINKS, RESOURCES AND RELATED EPISODES: Follow Gabriele and KnowledgeIsWatt on his website, Substack and Instagram The shownotes for today's episode can be found here. The full podcast episode archives (including category filters) can be found here. Limited reproducibility of individual physiological adaptations to repeated endurance exercise training - Odden et al. 2026 Heavy strength training effects on physiological determinants of endurance cyclist performance: a systematic review with meta-analysis - Llanos-Lagos et al. 2025 Effects of Exercise Training on Mitochondrial and Capillary Growth in Human Skeletal Muscle: A Systematic Review and Meta-Regression - Mølmen et al. 2024 Elite Aerobic Endurance Performance: Is It Really Related to Lactate Threshold Expressed Relative to Peak Oxygen Uptake? - Johansen et al. 2025 Strength training improves performance and pedaling characteristics in elite cyclists - Rønnestad et al. 2014 Five-Minute Power-Based Test to Predict Maximal Oxygen Consumption in Road Cycling - Sitko et al. 2022 SPONSORS: Precision Fuel & Hydration produce our favourite gels, sports drinks, and electrolyte and carbohydrate products here at That Triathlon Show and Scientific Triathlon. Use the free Fuel & Hydration Planner to get a personalised plan for your carbohydrate, sodium and fluid intake in your next event, and get 15% off your first 2026 order by using the code TTS2026 at checkout. Rouvy is hands down the most complete indoor cycling platform for triathletes. Among their thousands of beautiful bike courses from all around the world, all filmed in stunning quality, they have over 75 IRONMAN and IRONMAN 70.3 race courses plus 20+ Challenge Family courses, so you can pre-ride your race from home. Real gradients, real visuals, and real feel! Head to rouvy.com and use the code TTS to get your first month free on top of a 7-day free trial. Effortless Swimming produce the best swim goggles for triathletes and open water swimmers. Their NanoClear anti-fog lenses give you clear, fog-free vision that lasts and doesn't wear off. Don't let foggy or leaky goggles ruin another swim. Go to shop.effortlessswimming.com and use the code TTS15 to get 15% off your goggles, and get a free two-month Effortless Swimming course membership. ZenAI is the next frontier of podcasting. It lets you turn your ideas into a podcast without any knowledge of audio editing, video, or production. You do the talking, and the AI handles the production, editing, clipping, and the rest, and you can direct your AI producer in plain English. You can even record from your phone, so no expensive studio gear is needed to sound great. ZenAI is a new product from Zencastr, a platform I've been a paying customer of for over nine years here at That Triathlon Show. ZenAI is currently in invite-only beta. Join the waitlist today here.LEARN MORE ABOUT SCIENTIFIC TRIATHLON: The Scientific Triathlon website is the home of That Triathlon Show and everything else that we doContact us through our contact form or email me directly (note - email/contact form messages get responded to much more quickly than Instagram DMs)Subscribe to our NewsletterFollow us on InstagramLearn more about our coaching, training plans, and training camps. We have something to offer for everybody from beginners to professionals.HOW CAN I SUPPORT THAT TRIATHLON SHOW (FOR FREE)? I really appreciate you reading this and considering helping the show! If you love the show and want to support it to help ensure it sticks around, there are a few very simple things you can do, at no cost other than a minute of your time. Subscribe to the podcast in your podcast app to automatically get all new episodes as they are released.Tell your friends, internet and social media friends, acquaintances and triathlon frenemies about the podcast. Word of mouth is the best way to grow the podcast by far!Rate and review the podcast (ideally five stars of course!) in your podcast app of choice (Spotify and Apple Podcasts are the biggest and most important ones).Share episodes online and on social media. Share your favourite episodes in your Instagram stories, start a discussion about interesting episodes on forums, reference them in your blog or Substack. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What happens when a feeling we assume is a universal human experience is actually shaped, defined, and even created by our specific cultural language and material conditions? Macquarie University's Future Fellow at the School of Humanities, Dr. Katie Barclay, joins host PJ Wehry to discuss the overlooked complexities of a deeply human emotion. Dr. Barclay explores the history and cultural variety of this feeling in her book, Loneliness in World History. They examine how loneliness is frequently not just an internal psychological state, but rather a reflection of our relationships with our environment, our community, and the specific language we use to make sense of our world. In this conversation they explore: How the "language trap" challenges our ability to compare emotions across cultures, and why translating words for love and loneliness requires understanding their thick cultural context. The surprising nighttime weeping rituals of the Kaluli people in Papua New Guinea, where singing about loneliness serves as a cathartic communal release of pain. Why the historical narrative of human "modernization"—moving from supposedly primitive communal selves to modern individualized subjects—carries deeply colonial and problematic assumptions. The physiological elements of isolation, including "touch hunger" and how the modern internet trend of Mukbang satiates the deep-seated desire to eat alongside a community. How physical places and material architecture—from fairy-tale forests to utopian high-rise flats and car-centric suburbs—actively teach us to feel isolated and shape our emotional experiences. The paradox of the "lonely genius," revealing how the supposedly solitary pursuit of art and creativity is fundamentally dependent on an unseen network of community support and labor. This is a conversation for anyone interested in world history, anthropology, and the humanities who wants to understand the cultural weight behind our everyday emotions and how we can navigate our increasingly isolated, digital modern age. Make sure to check out Dr. Barclay's book: Loneliness in World History
To watch the video of this episode, please go to: https://youtu.be/LynPOS1pmow Have you ever felt trapped in a relentless cycle of hustle, pushing your body and mind to the absolute brink just to keep up with the demands of modern life? What if the chronic fatigue, anxiety, or physical illness you are experiencing isn't a permanent failure, but rather a build-up of "stress debt" that your nervous system hasn't been allowed to clear? How can simple, 60-second somatic tools like humming or physical movement instantly rewire our biochemistry from fight-or-flight to deep peace? In this episode of Kaleidoscope of Possibilities, Dr. Adriana Popescu sits down with Nic Monteforte, a former national executive, certified meditation teacher, and high-performance coach. Together, they pull back the curtain on the hidden epidemic of "stress debt" and "hustle culture" that dominates our professional and personal lives. Nic shares her personal journey from a high-stakes corporate collapse and severe physical illness to discovering the physiological secrets of nervous system regulation. This conversation is an open invitation to upgrade your internal operating system, stop grinding, and step into a life of sustainable peak performance, deep rest, and effortless clarity. In this episode: Demystifying Stress Debt: Discover how incomplete stress cycles accumulate in the body like a stack of pancakes, eventually causing the entire system to topple over. The Physiology of Sleep vs. Stress: Understand why you can sleep for eight to ten hours and still wake up exhausted due to stress clearing taking over your dream states. Finishing the Stress Cycle: Learn how to utilize quick, aggressive physical bursts – like 60-second star jumps or air squats – to shift your biochemistry in real time. Sound and the Vagus Nerve: Explore how simple, mouth-closed humming instantly activates the parasympathetic nervous system to flood your body with calming serotonin and oxytocin. Resources mentioned in this episode: Nic's Website: https://nicmonteforte.com/ Nic's Book Website: infinitecapacitybook.com Instagram: @nicmonteforte About Nic: Nic Monteforte is a former national executive, certified meditation teacher, and high-performance coach with over 30 years of expertise in leadership and wellbeing. She is the creator of the Stress Debt Economy™ and Infinite Capacity Formula™, two groundbreaking frameworks that help leaders reclaim up to 70% of lost potential and achieve sustainable peak performance. After navigating her own journey from burnout and financial collapse to clarity and success, Nic has dedicated her career to guiding executives, entrepreneurs, and high-achievers through profound transformations. She has helped hundreds of leaders recalibrate their nervous systems, reclaim energy, and lead with calm, presence, and power. Nic is the author of Infinite Capacity, How to Calm Down Before You Blow Up, and A Busy Parent's Guide to Raising Super Healthy Kids. She holds advanced qualifications in education, fitness, and Vedic studies, and partners with clients worldwide to build the clarity, resilience, and vitality required to meet the challenges of modern leadership. Today, she is recognized as a leading authority on stress transformation and performance, inspiring audiences and clients alike to break free from stress debt, unlock their infinite capacity, and create extraordinary lives. “Burnout is just a completely dysregulated nervous system because of the stress debt that they've built up in their body, that their nervous system doesn't have capacity to do one more thing.” – Nic Would you like to continue this conversation and connect with other people who are interested in exploring these topics? Please join us on our Facebook group! (https://www.facebook.com/groups/kaleidoscopeofpossibilitiespodcast/) About your host: Dr. Adriana Popescu is a clinical psychologist, addiction and trauma specialist, author, speaker and empowerment coach who is based in San Francisco, California and practices worldwide. She is the author of the book, What If You're Not As F***ed Up As You Think You Are? For more information on Dr. Adriana, her sessions and classes, please visit: https://adrianapopescu.org/ To find the book please visit: https://whatifyourenot.com/ To learn about her trauma treatment center Firebird Healing, please visit the website: https://www.firebird-healing.com/ You can also follow her on social media: Facebook: https://www.facebook.com/DrAdrianaPopescu/ Instagram: https://www.instagram.com/dradrianapopescu/?hl=en LinkedIn: https://www.linkedin.com/in/adriana-popescu-ph-d-03793 TikTok: https://www.tiktok.com/@dradrianapopescu? Medium: https://medium.com/@dradrianapopescu Disclaimer: This podcast represents the opinions of Dr. Adriana Popescu and her guests. The content expressed therein should not be taken as psychological or medical advice. The content here is for informational or entertainment purposes only. Please consult your healthcare professional for any medical or treatment questions. This website or podcast is not to be used in any legal capacity whatsoever, including but not limited to establishing “standard of care” in any legal sense or as a basis for legal proceedings or expert witness testimony. Listening, reading, emailing, or interacting on social media with our content in no way establishes a client-therapist relationship.
For the past few episodes, we have focused heavily on how Blood Flow Restriction (BFR) aids in clinical rehabilitation and injury recovery. Today, we are shifting our focus to elite athletic performance and look at a study examining the hormonal impacts of adding a practical BFR finisher to the rigorous resistance training programs of collegiate American football players. The core problem strength and conditioning coaches face is maximizing the anabolic environment for their athletes without inducing excessive catabolic stress. This episode unpacks how a brief, 10-to-12-minute BFR finisher at 20% of a 1-Repetition Maximum (1RM) can significantly elevate salivary testosterone over a seven-week period when paired with a high-volume traditional training program. We explore the physiological roles of testosterone and cortisol at the tissue level, the importance of the testosterone-to-cortisol ratio, and why the time of day you train (and test) matters enormously. References Luebbers, P., Kriley, L., Eserhaut, D., Andre, M., Butler, M., & Fry, A. (2025). Salivary Testosterone and Cortisol Responses to Seven Weeks of Practical Blood Flow Restriction Training in Collegiate American Football Players. Frontiers in Physiology. Beaven, C. M., et al. (2008). Significant strength gains observed in rugby players following training protocols optimized for individual salivary testosterone responses. Discussion Points The Role of Hormones in Hypertrophy: How testosterone binds to androgen receptors to trigger structural remodeling, and why cortisol, a glucocorticoid, acts as a catabolic counterbalance. Study Methodology: The 7-week trial involving 58 collegiate football players, split into groups comparing traditional high-intensity training with and without a practical BFR finisher. The BFR Protocol: A practical, field-ready protocol using 4 sets (30-20-20-20 reps) of back squats and bench presses at 20% 1RM with 45 seconds of rest. Key Findings on Testosterone: Only the group combining high-volume traditional training with the BFR finisher saw significant increases in salivary testosterone from week 1 to week 7. Cortisol and Adaptation: A blunted post-exercise cortisol response across all groups after 7 weeks, indicating positive physiological adaptation and improved training tolerance. Diurnal Variations: The crucial difference between morning and afternoon hormonal profiles, and why afternoon training showed a clearer increase in the anabolic-favorable T:C ratio. Key Topics Covered - Elite Athletic Performance and BFR - Endocrine Responses to Resistance Training - Salivary Hormone Measurement (Free Testosterone vs. Total Testosterone) - Programming BFR Finishers in Team Sports - Managing Catabolic Stress and Recovery Thanks for listening, and remember to keep the pump! Chris
The Real Truth About Health Free 17 Day Live Online Conference Podcast
Explore biological dentistry, oxygen therapies, and extended fasting as tools to reverse the cancer process and restore health. #OxygenTherapy #WaterFasting #CancerReversal #BiologicalDentistry
Training isn't just about replicating race demands. It's about understanding the physiology that drives performance.In this episode, Dr Gabriele Gallo, founder of Knowledge is Watts, joins us to explore the concept of a physiology first approach to endurance training. Together, we discuss why successful coaching goes beyond chasing power numbers, how low and high intensity training work together over different timeframes, and why durability may be one of the most important frontiers in endurance performance.The conversation also explores fatigue resistance, carbohydrate availability, muscle damage, central fatigue, and how emerging technologies and AI may help coaches better understand the complex relationship between physiology and performance.Whether you're a coach, athlete, or sports scientist, this episode offers practical insights into building long term endurance through smarter training principles rather than simply copying race demands.Interested in learning more about the latest developments in endurance performance and sports science? Subscribe to the HIIT Science email list for updates on new research, courses, and educational opportunities.https://www.knowledgeiswatt.com/https://knowledgeiswatt.substack.com/Today's speakers:Prof Paul Laursen https://www.paullaursen.com/Gabriele Gallo https://x.com/knowledgeiswattAthletica Uhttps://youtube.com/playlist?list=PLu7L8NU083obOOZnkl9qd1lxr5zfVKTkL&si=YkGXTSQsJcYBUPiD
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Around 25 years ago, Ardem Patapoutian set out to investigate the fundamental biology behind our sense of touch. Through a long process of gene elimination, he identified a class of sensors in the cell membrane that turn physical pressure into an electrical signal. He changed the game in the field of sensation and perception, and in 2021 shared the Nobel Prize in Physiology or Medicine for his work. He joined Host Flora Lichtman in November 2025 to talk about his research, the odd jobs he worked along the way, and how he found a sense of belonging in science. Guests: Dr. Ardem Patapoutian is a professor and the Presidential Endowed Chair in Neurobiology at the Scripps Research Institute in La Jolla, California. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Women are often told to be careful with aging bones. Go light. Don't lift heavy. In this episode, I break down why that advice is backward, and what the research says to do instead.After menopause, bone and muscle break down at the same time, driven by the same drop in estrogen, and almost no one connects those dots for you. I cover how fast women lose bone, why muscle loss tracks right alongside it, why women carry more risk than men, and why heavy strength training is the most proven way to fight back.We dig into the landmark LIFTMOR trial, where postmenopausal women with low bone mass lifted heavy, safely, and built bone in the places that tend to break, plus evidence that strength training works into your 90s and a simple way to start if heavy lifting feels intimidating.In this episode:How fast women lose bone after menopauseWhy osteoporosis stays silent until something breaksHow muscle loss tracks alongside bone lossWhat the LIFTMOR trial proved about lifting with low bone massWhy intensity matters, and why it's never too late to startStudies referenced:Bone loss & resistance training (Frontiers in Physiology, 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC9941565/Muscle loss meta-analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739568/Women's sarcopenia risk & first-line treatment (Frontiers in Public Health, 2025): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883749/LIFTMOR Trial (Watson et al., 2018): https://pubmed.ncbi.nlm.nih.gov/28975661/Strength training to age 96: https://pubmed.ncbi.nlm.nih.gov/10721690/Train with us at Prepare for Performance (PFP) in Rockville, MD, serving the DMV.
Episode Overview In this episode, we explore the alarming surge in cardiac care demand and its direct link to systemic leadership stress. Featuring insights from Michael D. Levitt, Founder and Chief Burnout Officer of Breakfast Leadership, we move beyond the idea of "bad luck" to examine how broken organizational systems are literally breaking the hearts of executives. Key Highlights & Statistics The Cardiac Surge: Demand for outpatient cardiology procedures is projected to increase by 25% over the next decade, while the industry itself is growing at a 4% compound annual rate. A Workforce Crisis: Cardiovascular disease claims a life every 33 seconds in the U.S.. Crucially, one in five cardiovascular deaths occurs in adults younger than 65—working-age leaders who are often high-performing until the moment of a health crisis. The Physician Shortage: While demand spikes, the Association of American Medical Colleges projects a shortfall of over 7,000 cardiologists by 2034. Physiology of Stress: Chronic workplace stress is not just a "feeling." It triggers a physiological chain reaction: Elevated cortisol leads to chronic inflammation, which accelerates cardiovascular disease. The "Leadership OS" Failure Michael Levitt shares his personal journey of surviving a 2009 cardiac event and the 369 days of "worst-case scenarios" that followed. He argues that you "cannot meditate your way out of a broken system" and identifies three structural pillars that, when missing, create toxic stress: Decision Clarity: Without it, leaders operate in permanent ambiguity, causing sustained cortisol elevation. Operational Rhythm: A lack of rhythm means the nervous system never fully recovers between demands. Culture Infrastructure: Broken culture forces individuals to absorb systemic dysfunction rather than the system holding it. Actionable Solutions for Executives and HR To prevent leadership health events from becoming business continuity crises, organizations must make three structural commitments: Measure Stress Drivers: Track decision fatigue, role ambiguity, and "always-on" communication norms. Design for Recovery: Treat recovery as a prerequisite for performance, not a reward for it. Preventive Investment: View leadership health as a business continuity issue; it is cheaper to protect a leader than to replace one. Featured Resources Book: 369 Days: How To Survive The Worst Year Of Your Life by Michael D. Levitt. Organization: Breakfast Leadership Network – Specializing in burnout prevention and leadership strategy. Featured Practice: San Diego Cardiac Center – A model for specialized, patient-centered cardiovascular care. Tool: Schedule a Leadership Diagnostic to identify structural stress points in your organization. The Bottom Line "Your leadership system either protects the people inside it, or it quietly depletes them. There is no neutral position".
Jeff Granville, Founder and President of Mindful Presents is a Mindfulness Practitioner. Coherence Counselor. Spiritual Advisor, and Trauma Specialist. He is endorsed by Bruce H. Lipton, Ph.D., and Bruce Cryer, former CEO, HeartMath. Jeff served for 4 years as a member of the Family advisory council at Seattle Children's Hospital and trained as a first responder in the Parent Support team. He served on the nurse training, anesthesiologist training, Root Cause Analysis and Hospital Acquired Condition panels. As well as consultant to the clinical efficacy department.Jeff is a 5th generation inhabitant of the San Juan Islands, growing up on and around the waters or the Pacific Northwest. And is a father of 8 and Grandfather of 10 beautiful children.After his youngest son Makoy was diagnosed with a rare form of T-cell Leukemia, Jeff became a Mindfulness Practitioner and formed the nonprofit Mindful Presents to bring the gift of mindfulness, coherence and controlled breathing to pediatric patients, families and care providers.Since then, Jeff has opened up his services to the general public and specializes in Coherence Breathing, STIR; Somatic Trauma Imprint Release and aspect reintegration.Mindfulpresents.orgjeff@mindfulpresents.orghttps://www.facebook.com/MindfulPresents.orghttps://www.youtube.com/@jeffgranville4790360-941-7005More about Liz:Work- https://www.raisethevibewithliz.com/Radio Show- https://www.voiceofvashon.org/raise-the-vibePodcast- https://www.buzzsprout.com/958816Facebook- https://www.facebook.com/raisethevibewithlizInstagram- https://www.instagram.com/raisethevibewithliz/*** Support the show! https://www.buzzsprout.com/958816/supporthttps://paypal.me/LisbethPeterson?country.x=US&locale.x=en_USJoin The Community!
Many people are told their elevated cholesterol and LDL levels are simply the result of diet, lack of exercise, or genetics. But what if rising cholesterol is actually a clue that thyroid physiology is slowing down? In this episode of the Thyroid Answers Podcast, Dr. Eric Balcavage explains the important relationship between thyroid signaling, T4 to T3 conversion, cellular metabolism, liver function, bile production, and cholesterol regulation. He discusses why cholesterol is essential for health, how the body produces and uses it, and why elevated cholesterol may be a sign that the body is struggling to convert food energy into cellular energy efficiently. Dr. Balcavage breaks down several mechanisms by which reduced thyroid signaling may contribute to elevated cholesterol and LDL levels, including decreased T4 to T3 conversion, impaired cholesterol transport, reduced LDL receptor activity, diminished bile production, and impaired bile flow. He also explains why simply lowering cholesterol with medication may not address the underlying physiologic stressors driving these changes. If you've been told your cholesterol is high despite eating well, exercising regularly, and doing all the "right" things, this episode explores why it may be time to look deeper at thyroid physiology, cellular metabolism, inflammation, liver function, and the body's adaptive stress response. In This Episode, You'll Learn: Why cholesterol is essential for hormone production, cell membranes, vitamin D production, brain health, and bile formation How reduced T4 to T3 conversion can contribute to elevated cholesterol and LDL levels The critical role T3 plays in liver function, cholesterol transport, and bile production Why cholesterol may rise even when diet and exercise habits are healthy How impaired bile flow and gallbladder function can affect cholesterol clearance Why elevated cholesterol may be a sign of reduced thyroid signaling rather than simply a dietary problem The lab markers Dr. Balcavage uses to assess thyroid physiology, inflammation, metabolism, and cholesterol regulation Why addressing cellular stress and adaptive physiology is often more important than simply lowering cholesterol numbers Resources Mentioned:
Meet Dr. Shawna Pandya, Canada's first named female commercial astronaut and a leading figure in space medicine. From emergency medicine to aquanaut missions and suborbital research flights, Shawna has trained to thrive in some of the most extreme environments on Earth—and soon, in space. In this episode, she shares her journey from a childhood inspired by Dr. Roberta Bondar, through neuroscience and medical training, to testing spacesuits in zero gravity and completing multiple NEPTUNE aquanaut missions. We dive into: The challenges of spaceflight on the body and mind The "RIDGE" framework Radiation, Isolation, Distance, Gravity, Environment Using emergency medicine, diving, and piloting to build operational readiness Maintaining balance, avoiding burnout, and living a life aligned with values Preparing for her upcoming flight with Virgin Galactic Shawna's story is a masterclass in perseverance, curiosity, and aiming for the stars—literally. *** New episodes of the Tough Girl Podcast drop every Tuesday at 7 AM (UK time)! Make sure to subscribe so you never miss the inspiring journeys and incredible stories of tough women pushing boundaries. Do you want to support the Tough Girl Mission to increase the amount of female role models in the media in the world of adventure and physical challenges? Support via Patreon! Join me in making a difference by signing up here: www.patreon.com/toughgirlpodcast. Your support makes a difference. Thank you x *** Show notes Who is Shawna Being Canada's first named female Astronaut Her early years and growing up in the 90s Wanting to be an Astronaut since she was a child and being inspired by Dr. Roberta Bondar Simplifying things Wanting to follow in her footsteps Doing a neuroscience degree The influence of her parents Girl Guides of Canada Doing outdoor education during junior high and building her spirit of adventure Inheriting her work ethic from her parents - thinking the normal work day was from 7am to 10pm Sharing her goal and telling people what she wanted to achieve Taking a family trip to Australia at 12 years old and being obsessed with the Southern Night Sky Not knowing if it will work out or not - Having to love the grind and the journey Keeping focused on the goal Not letting other people opinions stop her Her parents wanting her to have a realistic career ambition The roadmap included medicine After doing her undergrad in neuroscience and applying for medical school Having a back up plan - just in case International Space University - Masters Program Asking medical school for a deferral Doing an internship at the European Space Agency European Space Centre and making a meaningful contribution to space medicine Dealing with criticism Having balance in her life and not suffering from burnout Pursuing the trajectory as a research astronaut - and still maintaining her clinical hours in emergency medicine Work life balance Why she does't burn out Living her life according to her values Having complete control over her schedule Being surrounded by good people Finding fulfilment and loving what she does Being inspired to be a better version of herself everyday Fitness and health in space Bone density and muscle mass Space Medicine The challenges of space flight environment and why it's trying to kill you The "RIDGE" Framework short for Space Radiation, Isolation and Confinement, Distance from Earth, Gravity fields, and Hostile/Closed Environments. Altered day night cycles - 1 sunrise/sunset every 90 mins - 16 sunrise - sunset cycles per 24hr period every and how it interferes with your sleep cycle Micro-gravity and how it affects your bodily systems Physical activity as therapy and using it as a way of investing in herself. The days she doesn't make it to the gym Needing to change something up - or end up burning out Learning diving skills and spending time underwater Looking for transferable skills Being operational good and a good team mate Operational environments: - emergency medicine, diving, sky diving and piloting The importance of having aqua-naught experience Going on 2 NEPTUNE Missions NEPTUNE (Nautical Experiments in Physiology, Technology and Underwater Exploration) Building her space flight readiness Learning to handle stress in challenging situations Why there is no room for ego Using emergency medicine as an example Escalation patterns of communication Question - Suggestion - Statement - Command Why there is a time and place for everything If everything is urgent - nothing is urgent! Urgency fatigue - not knowing what do first Being aware of what tools you have at your disposal High risk - high reward scenarios The countdown to flight Since 2021 - the launch of private companies into space Going to space for research What kind of astronaut do you want to be? Being a research astronaut Training flights as a team - and getting to fly with her good friends Kellie Gerardi Dr. Norah Patten Figuring out research priorities The outreach aspects of what they do Science diplomacy The lead up to the space flight Managing fears and concerns Having a job to do Being aware of the need to be prepared Deciding on the final payloads Dealing with periods in space Quick Fire Questions Being an evening person Not scheduling early morning meetings Starting her day at 9am Favourite movie and favourite space movie 2007 movie - Sunshine Book inspiration - Chris Hatfield - An Astronaut's guide to Earth Music inspiration - liking high adrenaline workout play lists Liking the John Wicks Soundtrack Beach or mountains.. Favourite food at home and in space High RPM skipping Rest and relaxation Her love for birds - having a 56g Lovebird - 'Jules' Mantra and words she lives by - 'You've got this" Words from mum - "Keep going" - "Keep moving" Words from dad - "What's the difference between success and activity? Success is eating tomato soup with a spoon, activity is eating tomato soup with a fork" How to connect and follow along on social media Final words of advice and wisdom for other girls who want to pursue Pick what you want to do, aim to be really, really good at it. Aim to become the hardest working person in the room. Because the work ethic is free. Work really hard to get to where you want to be and then act like you belong there, because you do. You just need to make space for yourself. Social Media Website: shawnapandya.com Linkedin: www.linkedin.com/in/shawnapandya Instagram: @shawnapandya Facebook: @shawnapandyaofficial
Have you ever woken up with a racing heart, a tight chest, or a sudden, overwhelming sense of dread? Whether it hits at 3:00 AM or in the middle of a Tuesday meeting, a panic attack can feel like a medical emergency. In today's episode, we deconstruct the physiology of panic and provide you with the clinical tools to outlast the wave and return to calm.I'm Martin, a clinical hypnotherapist and former paramedic. Having sat with many people in the midst of a physical crisis, I'm here to tell you: your heart is not failing—it is protecting you.Time Chapters00:00 – Identifying the "Full Body Panic Signal" 01:10 – Meet Martin: From Paramedic to Hypnotherapist 02:00 – The Physiology of Panic: Why Adrenaline Makes Your Chest Tight 03:15 – The 3-Minute Rule: Understanding the Biological Half-Life of Adrenaline 03:45 – The "Brake Cable" Breath: Guided Physiological Sigh 05:05 – Shoreline Visualization: Watching the Wave Break 07:45 – Grounding Affirmations for Lasting Calm 08:50 – 3 Daily Caring Tips for Panic Recovery 10:40 – Final Thoughts: Coming Back to the Present Affirmations for Panic RecoveryLet these words land in your body to help signal to your nervous system that the "emergency" is over:“This is a panic attack; I am not in danger.” “My heart is strong; it is working to protect me, not hurt me.” “Adrenaline is clearing from my body with every breath I take.” “The wave is already breaking; I am already returning to calm.” “I have survived every panic attack before this, and I will survive this one too.” 3 Daily Caring TipsName It to Tame It: When symptoms start, say "This is a panic attack" out loud. This shifts brain activity to your prefrontal cortex, the rational side of your mind.Don't Leave the Room: Avoid the urge to flee. Staying in the location teaches your brain that the environment is actually safe, updating your internal "safety map".Rest After, Not Instead Of: A panic attack is physically exhausting. Treat yourself with kindness afterward—hydrate, move gently, and allow for quiet time.A Note From MartinIf you're tired of just "surviving" these moments and are ready to stop them at the source, I invite you to join me for my Anxiety Circuit Breaker Course. It features five focused hypnotherapy sessions designed to help you reclaim your life from the clinical roots of anxiety.You don't have to walk this path alone. You are capable, resilient, and stronger than your anxiety knows.Join the community at calminganxiety.fm In everything you do today, my friend, be kind.
Today we have Dr. Dominic D'Agostino, who over the past 10 years has been a frequent guest on STEM-Talk. Today Dom joins us to give us an update on his recent research into ketogenic metabolic therapies, ketone supplements as well as hyperbaric oxygen therapy for traumatic brain injuries. Dom and his lab at the University of South Florida have published more than 20 papers since his last appearance on STEM-Talk in 2023. Dom is an Associate Professor in the Department of Molecular Pharmacology and Physiology at South Florida's Morsani College of Medicine. Dom has a background in neuroscience, molecular pharmacology, nutrition and physiology. In addition to developing and testing metabolic-based therapies, Dom's lab also investigates seizure disorders, brain cancer, neurodegenerative diseases and rare genetic-metabolic disorders. Show notes: [00:03:28] Dawn welcomes Dom back to the show and explaining that he has been quite busy since his last appearance, authoring or co-authoring more than 20 papers. Over the past several years, Dom has been helping to advance the science and application of ketogenic metabolic therapy (KMT) with colleagues at Moffitt Cancer Center, particularly focusing on using KMT to enhance immune-based therapies for certain types of cancers. Dawn asks Dom about this collaboration. [00:05:04] Dawn explains that ketogenic metabolic therapy is a dietary approach that focuses on a high-fat/low-carb diet to reduce glucose availability for cancer cells, potentially slowing their growth and improving treatment outcomes. It has been explored as a complimentary treatment for a variety of cancers including gliomas by shifting the metabolism of tumor cells away from glucose. Dawn asks Dom to explain what is involved in KMT. [00:06:58] Dawn clarifies that KMT requires less than 20-25 grams of carbohydrates per day, and that ketosis is a metabolic state in which the body switches from glucose metabolism to metabolizing fats in the form of ketones. Dawn goes on to explain that cancer cells typically consume glucose at a higher rate than normal cells. However, cancer cells are also very adaptable, and Dawn asks Dom to talk about this feature of cancer cells. [00:09:14] Ken explains that KMT has shown the most promise in treating high-grade gliomas, or brain cancers, such as glioblastoma, which is the most aggressive primary brain tumor in adults. Ken explains that Dom was part of a massive review titled “Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma,” which proposed guidelines for the management of glioblastoma based on an understanding of cancer as a metabolic disease, particularly involving mitochondria. Ken asks Dom to talk about this review. [00:11:21] From a patient advocacy perspective, Ken notes that the review recommends that there should be an aggressive education campaign that can arm patients with knowledge about KMT and other novel therapies. Ken asks Dom to talk about that recommendation. [00:13:15] Ken asks about the process of cutting the review from upwards of 200 pages down to around 50 pages with 49 authors. [00:15:04] Dawn mentions that Dom was part of another paper in 2024 titled “Targeting the mitochondrial stem cell connection in cancer treatment – a hybrid orthomolecular protocol.” Dawn explains that this paper looked at the mitochondrial stem cell connection theory (MSCC), which argues that cancer originates from chronic oxidative phosphorylation insufficiency in stem cells. This insufficiency leads to the formation of cancer stem cells and abnormal energy metabolism ultimately resulting in malignancy. There were 16 research centers and organizations involved in this paper which introduced a hybrid orthomolecular protocol to target the mitochondrial stem-cell connection. Dawn asks Dom to give an overview of MSCC. [00:18:26] Dawn explains that in this paper Dom and his co-authors propose a protocol that would enhance oxidative phosphorylation and inhibit the primary fuels of cancer, glucose and glutamine. This would target both cancer stem cells and metastasis. Dawn asks Dom to explain why this concept is attracting so much interest as a potential therapeutic approach for cancer. [00:20:48] Dawn asks if Dom could discuss the orthomolecular protocol, which is an approach that focuses on preventing and treating diseases by correcting nutritional balances in the body. [00:24:41] Ken asks if the proposed dietary intervention in the orthomolecular approach is different from a standard or typical ketogenic diet. [00:26:48] Ken shifts the discussion to talk about ketone supplements, explaining that Dom recently published a paper titled “Divergent hepatic outcomes of chronic ketone supplementation.” Ken goes on to explain that ketone salts preserve liver health, while some ketone esters and precursors appear to drive inflammation and steatosis. There is a lot of interest in ketone supplementation because they substantially elevate circulating ketones without having to restrict carbohydrates as strictly. The problem, as Ken explains, is that the long-term hepatic safety of ketone supplements remains unclear. In the aforementioned paper, Dom's rodent study evaluated the formulation-dependent impact of chronic ketone supplementation on liver histopathology, inflammatory signaling and systemic biomarkers. Ken asks Dom to discuss this paper and its findings and to give an overview of the various ketone supplements currently available. [00:30:49] Dawn asks Dom to dive into the methods and findings of the rodent study. [00:34:36] Ken asks Dom what his confidence is in the rodent model used in this study, and what are the next step for further research. [00:37:47] Regarding the two different doses given to rats in the study, Ken asks Dom how these doses correlate to doses in humans [00:40:23] Ken mentions that Ben Bikman, who was our guest on episode 143, published a study in February which Dom helped co-author. It examined the effects of ketone supplements on liver function. Ken asks Dom to discuss this study. [00:44:38] Dawn pivots to ask about a joint paper that Dom did with Andrew Koutnik, who was our guest on episode 185, on carbohydrates and physical performance titled “Carbohydrate ingestion on exercise metabolism and physical performance.” Dawn asks Dom to talk about this paper, which showed that a small amount of carbohydrates is sufficient to fuel athletic performance, and how additional carbohydrate intake showed diminishing returns. [00:49:18] Ken follows up on the finding that endurance athletes who rely on carb loading can tend toward pre-diabetes. [00:51:39] Ken asks Dom about the University of South Florida trial that Dom is an advisor for on traumatic brain injury and hyperbaric oxygen therapy. [00:54:41] Dawn mentions that Dom recently had an editorial in Frontiers that gave an overview of the emerging applications of hyperbaric/hyperbaric-oxygen therapy in the treatment of different neurological disorders. Dawn asks Dom what the key points in that editorial were. [00:59:06] Dawn explains that Dom recently gave a lecture at IHMC (available to view on IHMC's YouTube page), on traumatic brain injury and the populations at greatest risk in that context. Dawn asks Dom to give an overview of how an injury to the brain can result in neurometabolic crisis. [01:02:53] Ken asks Dom, excluding occupation demographics, what demographic is most at risk for traumatic brain injury (TBI) and why. [01:04:45] Ken mentions that it is understandable the risk that young people face with TBI due to the activities that young people engage in. Older people, however, have increased risk of TBI from falling as well as an additional age-related biological component that young people are not subject to. Ken asks Dom to elaborate on this. [01:07:12] Dawn mentions that several years ago, Dom and his wife bought some acreage in the countryside and started farming and asks Dom how the farm life is going. [01:07:57] Dawn closes the interview asking how Dom's wife is doing.
The FIFA World Cup is taking place across the United States, Canada, and Mexico. It's often called the beautiful game, but is it really more science than art? This episode features Rachael Ralph, Hugh Hunt, and Alex Grantham on the physics of football; Tom Brownlee on elite player performance; Gill Cook on the psychology of fans; and Jan Wendt on whether AI can assemble a top squad. Like this podcast? Please help us by supporting the Naked Scientists
Cole Zesiger is a breakup and relationship coach, author, and content creator who specializes in helping people navigate heartbreak, healing, and healthy relationships. After experiencing a divorce at 23 and another difficult breakup soon after, Cole began openly sharing his journey online, eventually growing an audience of more than 750,000 followers across Instagram, TikTok, YouTube, and other platforms. Through his coaching programs, online community, and content, he has helped over 2,000 people work through breakups, strengthen their self-worth, improve communication, and build healthier relationships. His practical approach blends psychology, attachment theory, faith, and real-world experience to help people either reconcile in healthier ways or move forward with peace and confidence. Cole grew up in Utah and served as a missionary in the Manila Philippines Mission. He married his wife, Jocelyn, in 2023, and together they are raising their daughter, Daisy. When he's not coaching or creating content, Cole enjoys playing guitar, dirt biking, wildlife photography, and exploring the mountains. His debut book, Ex's and No's: The Breakup Advice You Don't Want to Hear, offers a roadmap for rebuilding confidence, healing attachment wounds, and creating lasting love. Links Ex’s and No’s: The Breakup Advice You Don’t Want to Hear CoachColeZesiger.com Watch the video and share your thoughts in the Zion Lab community Transcript available with the video in the Zion Lab community Highlights Cole Zesiger discusses navigating early divorce and breakups within the Young Single Adult (YSA) community of The Church of Jesus Christ of Latter-day Saints. The conversation focuses on dismantling the spiritual stigma surrounding failed marriages and provides actionable methods for processing relationship trauma. 00:02:06 – Cole’s Journey Through Divorce 00:05:08 – The Reality of Early Marriage Challenges 00:07:56 – Understanding Attachment Styles 00:10:41 – The Impact of Divorce on Self-Perception 00:12:27 – The Aftermath of Divorce 00:14:06 – Reflecting on Past Relationships 00:17:14 – The Importance of Community Support 00:20:27 – Addressing the YSA Experience with Divorce 00:22:09 – Normalizing Divorce in Church Culture 00:24:34 – Understanding God’s Role in Relationships 00:27:10 – Creating Depth in Relationships 00:30:02 – The Importance of Service in Marriage 00:32:11 – Supporting Those Experiencing Divorce 00:35:37 – Best Practices for YSA Leaders 00:39:30 – Building a Present Worth Living In Key Insights The Perfection Stigma: Many young Latter-day Saints internalize a strict cultural path (e.g., mission, temple marriage) as a guarantee of success, leading to intense shame, identity crises, and a sense of absolute personal failure if a marriage ends in divorce. Anxious Attachment and Relationship Mechanics: Childhood and mission environments can inadvertently cultivate anxious attachment styles, causing individuals to compulsively try to “will a relationship into existence” or over-sacrifice personal needs rather than assessing core value compatibility. God's Will and Adversity: Divine promptings to marry do not mean God guaranteed a problem-free relationship; rather, adversity and divorce can be part of a broader spiritual landscape designed to build critical emotional skills and resilience. The Physiology of Heartbreak: Neurologically, overcoming a major breakup mimics chemical detox patterns seen in severe substance withdrawals, highlighting that the profound grief experienced by individuals is an intense physiological reality that requires intentional time to navigate. Active Relationship Maintenance: Sustainable long-term intimacy requires entering the “deep end” of a relationship by prioritizing consistent service actions strictly to maintain one's own love for their partner rather than doing so out of a codependent need for constant reciprocation. Leadership Applications Initiate Purposeful Social Inclusion: Leaders should deliberately look out for divorced or grieving ward members, actively connecting them to peer networks and social activities to replace isolation with a forward-looking sense of belonging. Shift the Spiritual Narrative: When counseling individuals facing separation, leaders can help reframe their perspective from viewing divorce as an identity-defining failure or sin to treating it as a difficult life trial that offers space for grace and personal growth. The award-winning Leading Saints Podcast is one of the top independent Latter-day Saints podcasts as part of nonprofit Leading Saints’ mission to help Latter-day Saints be better prepared to lead. Find Leadership Tools, Courses, and Community for Latter-day Saint leaders in the Zion Lab community. Learn more and listen to any of the past episodes for free at LeadingSaints.org. Past guests include Emily Belle Freeman, David Butler, Hank Smith, John Bytheway, Reyna and Elena Aburto, Liz Wiseman, Stephen M. R. Covey, Benjamin Hardy, Elder Alvin F. Meredith III, Julie Beck, Brad Wilcox, Jody Moore, Tony Overbay, John H. Groberg, Elaine Dalton, Tad R. Callister, Lynn G. Robbins, J. Devn Cornish, Bonnie Oscarson, Dennis B. Neuenschwander, Kirby Heyborne, Taysom Hill, Coaches Jennifer Rockwood and Brandon Doman, Anthony Sweat, John Hilton III, Barbara Morgan Gardner, Blair Hodges, Whitney Johnson, Ryan Gottfredson, Greg McKeown, Ganel-Lyn Condie, Michael Goodman, Wendy Ulrich, Richard Ostler, and many more in over 800 episodes. Discover podcasts, articles, virtual conferences, and live events related to callings such as the bishopric, Relief Society, elders quorum, Primary, youth leadership, stake leadership, ward mission, ward council, young adults, ministering, and teaching.