Podcast appearances and mentions of Denis Noble

This week Bruce speaks about the work or Michael Levin, who is a biologist know for his work on cell cognition and collective intelligence or the idea that electrical signals between cells influence the formation of biological systems. His work has potentially massive implications in cancer research and other fields. Though rarely identified with 3rd way evolution, his work has more than a passing similarity to it. Like 3rd way evolutionists, he seeks to expand evolutionary theory beyond the alleged reductionism of a gene-centric or neo-Darwinian approach. Presumably, these bioelectric effects could be considered a kind of epigenetic or evolutionary process existing outside the genome.However, unlike the 3rd Way evolutionists, he's ready to back up his views with clever and shocking experiments that confront popular interpretations of gene-centric evolution head on.Can Levin's work possibly help us determine who is more right in the argument between 3rd Way evolutionists like Denis Noble or James Shapiro vs mainstream evolutionary biologists like Zach Hancock?Support us on Patreon

What if our cells have memory and cognition, which changes how medicine is done?In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss:- Cognition and creativity is not merely associated with the brain and nervous system- Implications of this view of cognition for regenerative medicine and longevity- Is stress response the source of our creativity?Episode Show Notes: https://livelongerworld.com/p/plyonFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 Intro, Basal cognition1:00 Our view of cognition is incorrect8:50 What does biology have to say about cognition?12:12 Cognition in xenobots14:20 Cognition and cooperation in microbes30:03 Bioelectricity and cognition33:58 Is stress response the source of our creativity?43:27 Mike's paper: Stress-sharing as a cognitive glue47:31 Implications of cognition not only being associated with brain56:55 Cognition in AI1:02:33 View of cognition in the EastAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram:https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://twitter.com/drmichaellevinPamela Lyon: https://www.adelaide.edu.au/directory/pamela.lyon#Episode Show Notes: https://livelongerworld.com/p/plyonALSO WATCH:Michael Levin & Denis Noble on What Biology Needs to Advance Longevity: https://open.spotify.com/episode/49WaTa4Vl67FU4zjjX1H6F?si=x1rjzVocS2OjSVdxpzNt5g

How well do the collection of assertions called “3rd way evolution” stand up to criticism? Here, in our second of at least 3 episodes on this topic, Bruce considers the criticisms of Denis Noble and James Shapiro by YouTuber and evolutionary biologist Zach Hancock in his epic video on the subject.  Perhaps the role of epigenetics is overstated, Lamarckism is not back,  and neo-Darwinism is not dead after all.

Denis Noble is Emeritus Professor and co-Director of Computational Physiology who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford. He is one of the pioneers of systems biology and developed the first viable mathematical model of the working heart. He is also a philosopher of biology, and his books The Music of Life and Dance to the Tune of Life challenge the foundations of current biological sciences, question the central dogma, its unidirectional view of information flow, and its imposition of a bottom-up methodology for research in the life sciences. Raymond Noble is Honorary Associate Professor at the Institute for Women's Health, University College London. He held a Rockefeller Senior Research Fellowship with a joint appointment in Physiology and Obstetrics and Gynaecology at University College London, where he became Deputy Dean of Life Sciences and Graduate Tutor in Women's Health and where he also taught medical ethics in reproductive health. He is a Fellow of the Royal Society of Biology and a chartered biologist, writing extensively on biological theory and philosophy, working extensively on how organisms sense their environment and make choices. TIMESTAMPS: (0:00) - Introduction (2:45) - Consciousness & the Mind-Body Dichotomy (12:50) - Biology's Evolution & the Importance of Stochasticity (18:00) - The Gene Delusion (25:35) - Arguments Against Richard Dawkins' "Selfish Gene" (35:45) - Moral/Philosophical Implications of The Selfish Gene (39:19) - Purposive Explanations of Life & Understanding Living Systems (45:40) - Ecological Intelligence (56:05) - Consciousness & the Self (1:05:07) - Biological Evolution from a Physiological Perspective (1:21:18) - The Music of Life (Unselfish Gene) (1:29:00) - Free Will & Dogma (1:36:03) - The Story of Noble Brothers (Differences & Similarities) (1:42:24) - When Two Became One (1:50:45) - Teleology & The Purpose of Life (Final Thoughts) (1:56:40) - Conclusion EPISODE LINKS: - Denis: https://tinyurl.com/7uzjuxxm - Ray: https://tinyurl.com/25z9jnk5 - Books: https://tinyurl.com/bdcpwetj - Denis' Publications: https://tinyurl.com/yr3es4ht - Ray's Publications: https://tinyurl.com/yunnfjc5 CONNECT: - Website: https://tevinnaidu.com - Podcast: https://creators.spotify.com/pod/show/mindbodysolution - YouTube: https://youtube.com/mindbodysolution - X: https://twitter.com/drtevinnaidu - Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu - LinkedIn: https://linkedin.com/in/drtevinnaidu ============================= Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism. The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems. Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast. We discuss: - DNA is not the blueprint of life - Why biology's reductionist approach is flawed - The errors in Neo-Darwinism - Epigenetic inheritance - How to advance the cure of diseases Episode Show Notes: https://livelongerworld.com/p/dnoble Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Denis as Mike Levin's hero 0:10 Denis's journey to systems biology; cell voltage is a global property of the cell 3:45 Advice to young researchers pursuing systems biology 7:00 “Absolutely everything is wrong with Neo-Darwinism” 14:10 Epigenetic inheritance 19:12 Genetic vs. other information used by organisms 23:48 Biology textbooks have to expand beyond DNA in 50 years 25:03 Epigenetic processes are ubiquitous 28:58 If not DNA, what is the blueprint of life 36:15 Rewriting biology textbooks is fundamental 39:57 “A lot of time has been wasted” (in biology) 46:52 Darwin on the “Origin of Species” 55:38 “Unfortunate that Philosophy and science have diverged” 1:00:31 Importance of Functional networks; DNA does not predict disease AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Denis's book Dance to the Tune of Life: https://a.co/d/3hvh5JW Episode Show Notes: https://livelongerworld.com/p/dnoble Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm

We're joined by Dr. Denis Noble, Professor Emeritus of Cardiovascular Physiology at the University of Oxford, and the father of 'systems biology'. He is known for his groundbreaking creation of the first mathematical model of the heart's electrical activity in the 1960s which radically transformed our understanding of the heart. Dr. Noble's contributions have revolutionized our understanding of cardiac function and the broader field of biology. His work continues to challenge long-standing biological concepts, including gene-centric views like Neo-Darwinism. In this episode, Dr. Noble discusses his critiques of fundamental biological theories that have shaped science for over 80 years, such as the gene self-replication model and the Weissmann barrier. He advocates for a more holistic, systems-based approach to biology, where genes, cells, and their environments interact in complex networks rather than a one-way deterministic process. We dive deep into Dr. Noble's argument that biology needs to move beyond reductionist views, emphasizing that life is more than just the sum of its genetic code. He explains how AI struggles to replicate even simple biological systems, and how biology's complexity suggests that life's logic lies not in DNA alone but in the entire organism. The conversation covers his thoughts on the flaws of Neo-Darwinism, the influence of environmental factors on evolution, and the future of biology as a field that recognizes the interaction between nature and nurture. We also explore the implications of his work for health and longevity, and how common perspectives on genetics might need rethinking. All the topics we covered in the episode: -The critique of Neo-Darwinism and the future of evolutionary theory. -Systems biology: Understanding life beyond the gene. -The complexity of biology: Why reductionism falls short. -Evolution and inheritance: The role of environment in shaping species. -Health implications of Dr. Noble's work: Longevity, lifestyle, and the limits of genome-based predictions. Join us for a thrilling discussion on the future of biology, evolution, and the practical implications for health and science. Follow our host, Waheed Rahman (@iwaheedo), for more updates on tech, civilizational growth, progress studies, and emerging markets. Timestamps: (00:00) - Intro (03:04) - Why Was The Last 80 Years of Biology Wrong? (08:17) - Where does Logic come from? (13:03) - Is Evolution Truly Random or Driven by Purpose? (22:05) - Is Nurture more important than Nature? (29:06) - Denis Noble calls for a rewrite of all Biology textbooks (32:48) - Is Neo-Darwinism Just a Model? Understanding the Difference Between Evolution and the Creationism Debate (39:22) - Natural Selection vs. Lamarckian Evolution: How Darwin Changed Our Understanding of Survival Traits (46:03) - Reductionism vs. Integrationism in Science: How the 'Third Way' Challenges Neo-Darwinism (49:43) - What Does Epigenetics Mean for the Average Person? How Denis Noble's Paradigm Shift Impacts Everyday Health and Life? (69:29) - Is Western Science Facing a Paradigm Shift? Rethinking How We Determine Truth and Health in Light of Eastern and Western Influences (75:21) - Why Reductionism Dominates Science: The Political and Practical Challenges of Embracing a Systems Biology Approach (82:49) - Can We Trust AI to Behave Ethically? The Need to Connect Philosophy with Technology in AI Development (86:46) - Outro

In my review of this most important book Understanding Living Systems by brothers Raymond and Denis Noble I show you how biology is beginning to move beyond the concept of the 'selfish gene' and turning to a more co-operative view of life.Find out how cells are embedded in organisms and it is our intelligence and agency that allows us to modify our genes to achieve co-operation *If you're suffering from Chronic pain, fatigue or anxiety, I CAN HELP*CONTACT ME: https://www.alchemytherapies.co.uk/Alchemy Therapies & Emotional MasterclassOTHER USEFUL RESOURCESGroup Healing Program: http://myemotionalaudit.comAuthor/Book site: https//patriciaworby.comPodcast: https://www.alchemytherapies.co.uk/po...121 and group therapy and training for stress related conditions like anxiety, fatigue and pain: https://alchemytherapies.co.ukSee in particular: Thrive! - an introductory mindbody connection program and The Emotional Audit for more intensive training.COMING SOON:Intensive Training Program: https://emotionalmasterclass.com

Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the heart and his influential contributions to the understanding of biological systems. Listen on Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e Become a YouTube Member Here: https://www.youtube.com/channel/UCdWIQh9DGG6uhJk8eyIFl1w/join Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!) Join TOEmail at https://www.curtjaimungal.org LINKS: - The Music of Life (Book) - https://amzn.to/4drSFSP - The Selfish Gene (Book): https://amzn.to/3zYLyTx - Understanding Living Systems (book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367 - Denis' article: https://www.nature.com/articles/d41586-024-00327-x - The Third Way of Evolution (website): https://www.thethirdwayofevolution.com/ Timestamps: 00:00 - Intro 02:05 - Overview of Lecture 04:30 - What is the Genome? 07:22 - Is the Genome the Book of Life? 12:16 - 20th Century Gene-Centric Biology is Wrong 18:03 - Neo-Darwinism is Incorrect 19:42 - Implications for Medical Science 27:17 - Next Steps for Biology 33:10 - A Challenge to the World's Scientists Support TOE: - Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!) - Crypto: https://tinyurl.com/cryptoTOE - PayPal: https://tinyurl.com/paypalTOE - TOE Merch: https://tinyurl.com/TOEmerch Follow TOE: - NEW Get my 'Top 10 TOEs' PDF + Weekly Personal Updates: https://www.curtjaimungal.org - Instagram: https://www.instagram.com/theoriesofeverythingpod - TikTok: https://www.tiktok.com/@theoriesofeverything_ - Twitter: https://twitter.com/TOEwithCurt - Discord Invite: https://discord.com/invite/kBcnfNVwqs - iTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802 - Pandora: https://pdora.co/33b9lfP - Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e - Subreddit r/TheoriesOfEverything: https://reddit.com/r/theoriesofeverything Join this channel to get access to perks: https://www.youtube.com/channel/UCdWIQh9DGG6uhJk8eyIFl1w/join #science #biology Learn more about your ad choices. Visit megaphone.fm/adchoices

Denis Noble is a renowned British biologist and pioneer in systems biology, known for his groundbreaking work on the heart and his influential contributions to the understanding of biological systems. Become a YouTube Member Here: https://www.youtube.com/channel/UCdWIQh9DGG6uhJk8eyIFl1w/join Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!) Join TOEmail at https://www.curtjaimungal.org Timestamps: 00:00 - Intro 00:20 - Neo-Darwinism is Dead 06:30 - Richard Dawkins Differences 17:02 - Purpose As Individual Agents / Purpose Given 26:05 - Function vs. Purpose in Living Systems 33:30 - Gaia Hypothesis (Lovelock) 37:46 - Anti-Natalist 41:52 - “The Only Free Will Worth Having” 46:52 - Stochasticity 52:50 - Rupert Sheldrake / Morphic Resonance 59:11 - Holism 01:06:32 - Dualism / Separate Laws for Separate Parts 01:18:01 - Multi-Cellularity Emerged Long Ago 01:34:00 - Maladaptive Evolution Happens All the Time 01:39:18 - Denis Noble & Richard Dawkins 01:45:27 - What is Purpose? (For Agents) 01:53:22 - Outro / Support TOE LINKS: - Richard Dawkins book: https://www.amazon.com/Selfish-Gene-Anniversary-Introduction/dp/0199291152 - Denis Noble's book: https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367 - Gerald Edelman's book: https://www.amazon.com/Neural-Darwinism-Theory-Neuronal-Selection/dp/0465049346 - Denis Noble's paper with Daniel Phillips: https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP284420 - The Music of Life (Denis' book): https://www.amazon.com/Music-Life-Biology-Beyond-Genes/dp/0199228361 - Dance to the Tune of Life (Denis' book): https://www.amazon.com/Dance-Tune-Life-Biological-Relativity/dp/1107176247 - Denis' Progress in Biophysics paper: http://www.voicesfromoxford.org/wp-content/uploads/2021/07/Shapiro-Noble-2021.pdf - The Illusions of the Modern Synthesis (Denis's paper): https://link.springer.com/article/10.1007/s12304-021-09405-3 - The Origin of Species (Charles Darwin's book): https://www.amazon.com/Origin-Species-Charles-Darwin/dp/0517123207 - Dawkins/Noble debate (transcript): https://www.denisnoble.com/wp-content/uploads/2023/02/TranscriptReferences.pdf Support TOE: - Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!) - Crypto: https://tinyurl.com/cryptoTOE - PayPal: https://tinyurl.com/paypalTOE - TOE Merch: https://tinyurl.com/TOEmerch Follow TOE: - NEW Get my 'Top 10 TOEs' PDF + Weekly Personal Updates: https://www.curtjaimungal.org - Instagram: https://www.instagram.com/theoriesofeverythingpod - TikTok: https://www.tiktok.com/@theoriesofeverything_ - Twitter: https://twitter.com/TOEwithCurt - Discord Invite: https://discord.com/invite/kBcnfNVwqs - iTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802 - Pandora: https://pdora.co/33b9lfP - Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e - Subreddit r/TheoriesOfEverything: https://reddit.com/r/theoriesofeverything Join this channel to get access to perks: https://www.youtube.com/channel/UCdWIQh9DGG6uhJk8eyIFl1w/join #science #biology #richarddawkins Learn more about your ad choices. Visit megaphone.fm/adchoices

Why did Antony Flew, one of the world's leading atheists, announce in 2004 that he believes in God? Why did atheist philosopher Thomas Nagel's 2012 book 'Mind And Cosmos' get him labelled as a heretic by his peers? Justin Brierley explores why the discovery of the DNA code, the search for the origin of life, the complexity of the cell, and the mathematical order of the universe are leading many scientists to speak of agency, purpose, and a 'Logos' behind life. He also hears from dissident thinkers such as Stephen Meyer, Roger Penrose, John Lennox, Denis Noble and Perry Marshall about the surprising rebirth of belief in a mind beyond matter. Biologist Sy Garte also tells his story of how as an atheist scientist, he was surprised by God. More info, book & newsletter: https://justinbrierley.com/surprisingrebirth/ Support via Patreon for early access to new episodes: https://www.patreon.com/justinbrierley/membership Support via PayPal: https://www.paypal.com/paypalme/brierleyjustin Support via Tax-deductible (USA): https://defendersmedia.com/portfolio/justin-brierley/ Buy the book or get a signed copy: https://justinbrierley.com/the-surprising-rebirth-of-belief-in-god/ Ep 20 show notes: https://justinbrierley.com/surprisingrebirth/episode-20-the-logos-behind-life-the-dissident-scientists-discovering-a-mind-beyond-matter The Surprising Rebirth of Belief in God is a production of Think Faith in partnership with Genexis, and support from The Jerusalem Trust & the Christian Evidence Society. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode Summary: On my next YOUNGER podcast episode, I interview the founder of Oxford-HealthSpan, a company that is now producing a high-quality spermidine called Primaeadine®. Many health practitioners are learning more spermidine. You will learn how it is a naturally-occurring and potent polyamine (a kind of protein) known for inducing autophagy, the body's cellular renewal and recycling process. It also inhibits 9 of the 12 Hallmarks of Aging, the paths down which we age. Oxford-HealthSpan is backed by leading longevity experts, to produce products formulated with the oversight of internationally recognized longevity scientists and doctors, including Oxford University Emeritus Professor of Physiology, Denis Noble and Immunology Professor and Autophagy Expert, Katja Simon, "Best in Medicine" Longevity Doctor and Author of ‘The Kaufmann Anti-Aging Protocol', Dr. Sandy Kaufmann, Celebrity Anti-Aging Doctor and Psychoneuroimmunologist, Dr. Olivia Lesslar, and Head of the UK's first-of-its-kind Space Innovation Lab and Autophagy Researcher, Dr. Ghada Alsaleh, among others. Guest Bio: Leslie Kenny, is the founder of Oxford HealthSpan. She is an Oxford based entrepreneur born in California and a graduate of Berkeley and Harvard Business School. In her 30s, her life changed dramatically when she was diagnosed with an array of autoimmune conditions - lupus, rheumatoid arthritis and hypothyroidism. Her doctors told her there was no cure and that they could only be managed with strong immunosuppressants. This didn't sit right with her. Coming from a Taiwanese background, she was raised with the mentality that its best to work with your body's innate wisdom to heal itself. Why would she suppress her immune system rather than support it in its natural abilities? On a quest to revive her own health, she went back to school at the Institute for Integrative Nutrition in NYC. Her passion for health optimization grew and her career took an interesting and unexpected turn when she moved to Oxford and began working with Oxford University scientists and doctors. Key Takeaways: ·      The science behind spermidine ·      Synthetic or not ·      Clean ingredients and whole-plant derived spermidine ·      3rd Party lab testing ·      Who benefits ·      Suggested dosage ·      What to expect ·      Foods highest in spermidine ·      Natural solution not a medical treatment ·      Quality spermidine supplements ·      What do health practitioners know ·      Where can I purchase Primaeadine® Resources for a Younger Lifestyle: The link to your Special Offer: https://oxford-healthspan.myshopify.com/drrobynbenson For more YOUNGER Podcast Episodes: https://robynbenson.com/podcasts/ Quotes: “2/3 of the spermidine found in the human body is produced endogenously, or in the body, by the gut microbiota and various tissues. The final 1/3 is found exogenously, or externally, in the food that we eat.” “As we age, our body's ability to produce it declines. To restore youthful levels of spermidine, we have to look externally. Otherwise, our cells' ability to trigger autophagy will continue to decline and the aging pathways will progress.”    

Biology against determinism!Looking for a link we mentioned? Find it here: https://linktr.ee/philosophyforourtimesWe all feel like we have free will. That our decisions are our own and that we could have chosen otherwise. But today, many prominent figures argue free will is an illusion. Join groundbreaking biologist Denis Noble as he argues that, in fact, our bodies hold the key to our freedom.Denis Noble is a renowned physiologist and one of the pioneers of Systems Biology. He is Emeritus Professor of Cardiovascular Physiology at Oxford University. Noble is known in his field for developing the first viable mathematical model of the working heart in 1960.There are thousands of big ideas to discover at IAI.tv – videos, articles, and courses waiting for you to explore. Find out more: https://iai.tv/podcast-offers?utm_source=podcast&utm_medium=shownotes&utm_campaign=free-will-is-not-an-illusionSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What are the problems that come from aging and what can we do about them? What is the importance of staying active in old age? What is autophagy and how does it relate to the aging process? Why is it that cancer often recurs? Are herbal remedies legitimate? What do we need to know about cholesterol? What is the importance of community on our health?Thank you to our sponsors:Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/AGEIST. LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products atInsideTracker.com/AGEIST.Denis Noble, 86, is an innovator, scientist, musician, ballroom dancer, and Oxford University Emeritus Professor of Cardiovascular Physiology. He joins us to discuss how to increase our healthspans and our lifespans, what we need to know about the aging process and how it impacts our health, the importance of community, and more. “As you get into long life but very unhealthy life, you're having a big burden on society. I'm not blaming people. I'm saying that this is what we're now seeing and I think we have to do something about it. I don't think we should accept that there is nothing you can do about it.” “There is absolutely no doubt that the biggest thing you can do to remain healthy in old age is to keep active even if it's difficult, it's best to keep active. You use it or you lose it.” “The aging population suffers from these multifactorial diseases with many genes involved and that will not yield to just more sequencing of people's genomes.”“When you attack a late-stage cancer, you may, hopefully, kill it off enough for a permanent cure. But that's, unfortunately, rarer than we once imagined it would be. Very often what happens is it produces a period of several years, which is good, when the cancer has retreated but it will then come back in an even more virulent form.”“To the degree you can do it, a healthy lifestyle in terms of diet is a good thing to go for. It's obvious also to tell your listeners that smoking is a no-no if yuo want to look after yourself in old age.” “You can't go run a marathon on a big full stomach and there's a good reason for that. The blood supply during digestion is attracted to the intestines. They need the blood supply in order to do the work that is necessary to digest the food that you've eaten.”“It's very important to try to arrange your life so that you're not alone, you do interrelate with people, and that's a huge health benefit to be with people and find ways in which you can communicate with others.”“We are designed, effectively, to be social people.” Listen to the SuperAge podcast wherever you get your pods.Connect with Denis Noble:Website

John Lennox is an Oxford mathematician who is the author of the new book Cosmic Chemistry. He's written many books about the relationship between science and religion and has debated Richard Dawkins and Christopher Hitchens. His new book candidly surveys the current state of evolutionary theory. Notable chapters include reviews of work by Denis Noble and James Shapiro. In this conversation that we had on the Oxford campus, John recounts his history of asking the big questions. LINKS:Cosmic Chemistry on AmazonJohn Lennox's University of Oxford Faculty pageJohn Lennox's Website See acast.com/privacy for privacy and opt-out information.

Are genes the primary units of selection and main drivers of adaptation? How does a gene's-eye view of evolution fit into modern biology? On this episode, we talk with Arvid Ågren, an evolutionary biologist and Wenner-Gren Fellow at Uppsala University, about his new book, “The Gene's-Eye View of Evolution”. The book chronicles the history of gene-centric views of evolution, which burst onto the scene in 1976 with the publication of Richard Dawkins's book, "The Selfish Gene". In the gene-centric worldview, genes and alleles take center stage as both key units of selection and drivers of the evolutionary process. Organisms and their phenotypes, by contrast, are viewed as transient vehicles – disposable somas constructed and controlled by genes whose purpose is simply to help those genes replicate. Previous guests on Big Biology, including Denis Walsh, Denis Noble, Mike Levin and others, have argued strongly for an opposing point of view: that organisms, not genes, should be the focal level for understanding evolution. On this episode, we challenge Arvid to reconcile the gene's-eye view with our more organism-centered views, and to account for important biological phenomena like the origin of life and adaptation. Our conflicting perspectives led to a stimulating conversation about the nature of evolution, whether the abstractions inherent to the gene's-eye view are justifiable, and how alternative conceptions of adaptation might lead to unification in biology. Cover art: Keating Shahmehri --- Send in a voice message: https://anchor.fm/bigbiology/message

What are the new relationships thought to be between cancer and evolution? Cancer can be considered in a new light by accepting a new definition and possible set of interactions. Listen up to learn: Why all may not be well in evolutionary theory What Julian Huxley may have gotten wrong How the immune system can offer clues about cancer Denis Noble, a member of the Department of Physiology, Anatomy, and Genetics at the University of Oxford, shares his view of the new links between Darwinism and cancer that may revolutionize the field.  It has been known that mutations play a role in cancer for a great while, but in recent years, the style of mutations has hinted at new lines of thinking. These new lines of thought have even caused a possible shift in the current and widely accepted theory of evolution. By assuming that control of the tumor only arises out of genetic sequencing, it is possible that the current method of examination may be short-sighted. After understanding the genome first, researchers also need to consider the downstream ramifications of the formation and operation of cancerous tumors. To learn more, visit https://www.aacr.org/professionals/membership/scientific-working-groups/cancer-evolution-working-group/. Episode also available on Apple Podcasts: apple.co/30PvU9C  

Today’s ID the Future features another installment in James Tour’s hard-hitting and evidence-based YouTube series on abiogenesis. Here Dr. Tour, a world-leading synthetic organic chemist at Rice University, describes the early Earth primordial soup concept for the origin of first life (OOL) and shows why it’s simplistic, bogus, and doesn’t represent the current science on the issue. He also reviews survey data showing just how misinformed the public is about how far scientists have gotten in creating life in the lab. One critic of Tour protested that the simplistic primordial soup story might be found in highly simplified textbooks for sixth graders but isn’t peddled at higher levels. Tour provides video evidence to the contrary. Source

Keith Littlewood B.Sc. PgD, M.Sc has been involved in the health, fitness and well-being industry for over 20 years and after working for a variety of organizations as a trainer for the likes of Matt Roberts and owning his own health club, he realized that he was more interested in helping others than managing others. He also worked at the prestigious Bowskill clinic working as a corrective exercise and rehabilitation specialist. He has worked around the world conducting rehabilitation and pop up clinics in Africa, Asia, the Middle East, US and the UK. *Endocrinology, biology and health related experience:* After gaining a degree in fitness and health, he studied areas such as metabolic typing, functional medicine (with the Institute of Functional Medicine), neurobiology of sleep with Michigan University and in 2017 gained a post graduate diploma in endocrinology with distinction from the University of South Wales. He has a specific interest in resolving hormone and other energy related issues that affect digestion, sleep, mood, fertility and health. He is influenced by the biological reasoning of scientists like Ray Peat, Denis Noble, Albert Szent Györgi, Hans Selye, Katherina Dalton and many others. In 2019 he received a masters of science degree in endocrinology with distinction, researching the accuracy of thyroid stimulating hormone in the face of mounting pollution, stress and nutrition factors. *Pain, biomechanics and movement experience:* His previous work as a rehabilitation and performance coach has evolved after originally completing the CHEK institute Level 3 practitioner and became a neuromuscular therapist. Since then he has also completed the selective functional movement assessment (SFMA) and Neuro Kinetic Therapy courses. Also undertaken short courses with the Neuro Orthopedic institute (NOI), Rehab School of Prague and Duke University/Neuroscience. He is Currently undertaking a course of study of Proprioceptive Deep Tendon Reflex – P.D.T.R with Orthopaedic Surgeon Jose Palomar which combines neuroscience and biomechanics. He also teaches courses on integrated approach to breathing, digestion, sleep and hormone related issues. More of Keith's work, resources and articles can be found at www.balancedbodymind.com More resources for and about this episode can be found on www.primitiveinitiative.com

Renowned for his knowledge and expertise in biology, University of Oxford Professor Denis Noble once again returns to the show to share his insight. Today's episode deals with the topic of viruses, and it is the first in what will be a thorough and compelling series on virology. Throughout the course of this series, Richard Jacobs will interview approximately 30 scientists and researchers, each with something unique and meaningful to contribute to the conversation. In this episode, you will learn: Why, evolutionarily speaking, some types of viruses multiply within the host's cells before killing the host's cells soon after, and why other viruses reside dormant within cells for years, often undetected What is actually going on during the “latency period” of a viral infection, and how the answer might have more to do with the reaction of the host's own immune system than the virus itself Why there seems to be a correlation between the mechanisms for viral spread and the types of cells infected by a given virus   The COVID-19 situation has created an unprecedented global stir of questions about viruses: Why would one type of virus have such a different structure and function than another type of virus? How do viruses spread, and why do they seem to trigger different immune responses in different people? Why can it be so challenging to find an effective way to eliminate them? Noble provides a great deal of compelling information on these topics and more, including the possible connection between exosomes and the origin of viruses, the ways in which the microbiome might change around a cell once the cell is infected by a virus, how viruses find their targets, and the role of viruses in evolution and speciation.   Learn more about Denis Noble's work and publications at https://www.thethirdwayofevolution.com/people/view/denis-noble. Available on Apple Podcasts: apple.co/2Os0myK

Virologist Jonathan Latham explains his view of living organisms in opposition to genetic or biological determinism. He shares a wide range of thoughts, including A theory of how COVID-19 began in a group of miners in Wuhan in 2012; How our societal structure self-corrects to understanding science through genetic or biological determinism, prioritizing genetics facts; and A different way to conceive of living organisms as constantly changing with nonhierarchical layers of cooperation rather than an over-emphasis on the importance of genetics.  Jonathan Latham, PhD, is the executive director and cofounder of the Bioscience Resource Project. He's the editor of Independent Science News and director of the Poison Papers project, which publishes documents on the chemical industry. In this podcast, he begins by engaging with ideas presented in a previous podcast when Richard spoke with famed biologist Denis Noble. Noble said that there's no privileged level of causation in biology and Latham continues to address this issue, offering his own commentary over the course of the show. He explains that he became interested in the kind of prominence that scientists give to genes and DNA and eventually came to the realization that there are a lot of flaws in how we think about organisms that stem from adherence to genetics facts and emphasizing the importance of genetics. He asserts that the only agency that exists in an organism is the one that derives from the organism itself and explains what this means in more concrete terms. He also touches on current projects such as a paper he and Allison Wilson wrote about their theory on the origin of SARS-CoV-2, which he believes was through a group of miners who experienced a mysterious disease in 2012. After explaining in more detail, he returns to the ideas of genetic determinism and talks about a book he's authoring on the topic. To find out more, he suggests getting on the mailing list of Independent Science News. Available on Apple Podcasts: apple.co/2Os0myK

James Tour, a renowned nanochemist at Rice University, has been openly critical of Origin Of Life literature for being too optimistic, too sanguine and at times misleading. See this video for example: www.youtube.com/watch?v=zU7Lww-sBPg When Perry Marshall took part in a discussion on the Unbelievable show with Denis Noble and Lee Cronin, host Justin Brierley mentioned Tour and his criticism. A reaction ensued, which led to Tour and Cronin going head to head on an international radio program and podcast. Here, we re-broadcast the scene that provoked the controversy and the debate that followed. See acast.com/privacy for privacy and opt-out information.

Prof of Nanotechnology James (Jim) Tour & Glasgow biology Prof Lee Cronin debate contemporary Origins of Life research and whether Lee’s laboratory is on the way to discovering it. You can watch/listen to the first Unbelievable? debate on this subject featuring Lee Cronin here: https://www.premierchristianradio.com/Shows/Saturday/Unbelievable/Episodes/Unbelievable-How-on-Earth-did-life-begin-Lee-Cronin-Perry-Marshall-and-Denis-Noble-on-the-origins-of-life Plus Justin speaks to Rev Richard Burridge about the 150th anniversary lecture event for the Christian Evidence Society.   For James Tour http://www.drjamestour.com/  For Lee Cronin http://www.croninlab.com/  For Unbelievable? the Conference 2020 https://www.unbelievable.live/ For A Evening with NT Wright on 12 March https://www.ecevents.uk/spck/tw/Site/Register For The Christian Evidence Society 150th anniversary event on 5 March http://christianevidence.org/blog/entry/celebrating_our_150th_anniversary  Subscribe to our newsletter and receive the free Unbelievable? e-book ‘In Conversation With…’ https://www.premier.org.uk/Unbelievablenewsletter  Support the show and receive all the videos sessions from Unbelievable? USA 2019 https://resources.premier.org.uk/supportunbelievable/ For more faith debates and extra resources visit http://www.premierchristianradio.com/Shows/Saturday/Unbelievable  Join the conversation: Facebook and Twitter Get the MP3 Podcast of Unbelievable? Via RSS or Via Itunes  

Denis Noble, CBE, Ph.D., FRS, the celebrated and outspoken British biologist, physiologist, and prolific author, discusses his incredible, noteworthy career in biology, exciting concepts in genetics, and the level of causation in biology.  Podcast Points: What is the current state of evolutionary theory? What do we know about cells and how they work? Issues regarding the genome and how diseases might originate British biologist, Noble has long been a major voice in modern biology. Dr. Noble was the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford for more than two decades. He was later named Professor Emeritus. Additionally, Dr. Noble was appointed the Co-Director of Computational Physiology. Dr. Noble is one of the earliest researchers in systems biology and he played an integral role in the development of the first mathematical model of the human heart. His thoughts on evolutionary theory have been part of a growing movement, a sort of revolution in evolutionary biology. Dr. Noble discusses his background and talks about what got him interested in his areas of research and study. As a self-described ‘card-carrying reductionist scientist,' Dr. Noble was interested in the concept of a privileged level of causation. And as he states, it was really always about, and is about, simply molecules. He recounts some early experiments he engaged in, attempts to reproduce the rhythm of the heart, with differential equations representing the molecular event. Which molecules are involved? This was an important question for the research. After much experimentation and study, he came to the conclusion that the cell itself is partially causing what happens. Rhythm only occurs by something that is constrained by the cell membrane. He explains the complex details of how the process works and how differential equations will not lead to answers unless the appropriate information is added into the mix.  The research scientist discusses how DNA is produced, and how cells have mechanisms for controlling errors. Cells, in short, have great control over what happens within systems. Dr. Noble goes on to discuss other important experiments, in the nervous system and other systems such as the immune system. Continuing, the Ph.D. expert talks about the genome. He discusses the origin of diseases and the fact that we know very little about biology above the level of the genome, in contrast to what we know about molecular biology in general. But remarkably, we still don't know exactly how cells work. 

Can chemistry crack the mystery of the origin of life? Or does the information required for Life to begin point beyond naturalistic explanations? Justin is joined by Perry Marshall who has established the $10m Evolution 2.0 Prize for anyone who can show a natural explanation for life. Lee Cronin of Glasgow University is confident that his experimental research could win it. Denis Noble also joins the conversation as they discuss the nature of life and whether current evolutionary theory can account for its origins. For Perry Marshall’s Evolution 2.0 Prize: https://evo2.org/  For Lee Cronin: http://www.croninlab.com/  For Denis Noble https://en.wikipedia.org/wiki/Denis_Noble  To subscribe for the advance video of Tom Holland & AC Grayling: https://www.premier.org.uk/Unbelievable-Newsletter  For The Big Conversation Season 2: www.thebigconversation.show  For more faith debates and extra resources visit http://www.premierchristianradio.com/Shows/Saturday/Unbelievable Join the conversation: Facebook and Twitter Get the MP3 Podcast of Unbelievable? Via RSS or Via Itunes 

Denis Noble, CBE, PhD, FRS, the famed British biologist, delivers an interesting overview of his life's work studying the intricate details of biology and what new developments can mean for the treatment of disease. As a celebrated British biologist, Noble held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford for two decades and was later bestowed the honor of Professor Emeritus and appointed Co-Director of Computational Physiology. Noble's work has been groundbreaking and he is one of the earliest pioneers of systems biology who developed the very first useful mathematical model of the heart, back in 1960. Noble talks in detail about extracellular vesicles (EVs), which are lipid bilayer-delimited particles—naturally released from a cell but, unlike a cell, they cannot replicate. He discusses the interior of cells, and explains how extracellular vesicles occur, touching on DNA and RNA, and the processes utilized by cells. As he explains, we “used to think that the cells were more or less cut off from each other,” but Noble states that this is just not true. Cells are actually exchanging information all the time, and the extracellular vesicles are little packets that contain information for exchange. The celebrated biology expert goes on to discuss how Darwin saw the potential significance of transgenerational information being passed on. Noble explains that we can use the expanding information to develop tools to diagnose and treat diseases earlier on, which will be incredibly beneficial of course to patients. Noble continues, and talks about how digital intelligence and AI can help to organize information and opportunities. He explains how intelligence is created, and discusses his theories on the topic. As one of the world's preeminent biologists and evolution scientists, Noble continues to lead some of the most pertinent discussions in the scientific community regarding life, genetics, and cellular processes.

I was recently counting my blessings when Denis Noble, author of 'Dance to the Tune of Life: Biological Relativity,' agreed for me to interview him, because I am very interested in his perspective on physiology. To my surprise, he put me in touch with Perry Marshall, author of 'Evolution 2.0,' and they both agreed to talk with me about the ongoing excitement around questions of information and purpose that are driving our understanding of evolution theory to a new level. Not one to miss!

At the Royal Society in Great Britain on May 31, 2019, Perry Marshall announced the Evolution 2.0 Prize was being doubled to $10M. Present in the room were Denis Noble, Fellow of the Royal Society, Dr. Paul Flather of Oxford, Clive Cookson Science Editor of the Financial Times, Investor Kevin Ham and several other scientists from the UK. Perry and Denis discuss the thinking behind the prize and the conversation includes open Q&A. See acast.com/privacy for privacy and opt-out information.

Denis Noble, one of the judges for the Evolution 2.0 Prize, discusses in this interview why we can't just put lipstick on a pig - why the public needs to be aware that evolutionary theory has undergone a revolution, and how this affects not only religious and philosophical discussions but policies and actions in medicine economics and politics.This interview was conducted by Ryan Bissett of Chasing Reality. Ryan has a PhD in molecular biology and five years of experience in biotech, but he eventually traded everything to go on a trajectory he could not have imagined. He lived in a van, packed wild food, and even lived as a Hare Krishna monk for five years. His aim now is to understand, "how can I synthesize my scientific training with my newfound narrative of existence?" You can check out his podcast as he interviews thinkers from different field of inquiry about fundamental questions of consciousness and reality, here: https://www.youtube.com/channel/UChz-a9985r_s6n2EeC6zTgg See acast.com/privacy for privacy and opt-out information.

To a biologist, Professor Denis Noble will need no introduction. His books - The Music of Life: Biology beyond the Genome (2006) and Dance to the Tune of Life: Biological Relativity (2016) - affected me considerably. His poetic writing style juxtaposed with convincing scientific evidence leads one to reconsider what one has been taught regarding the very nature of 'the organism.' In this podcast episode, Denis Noble delves into why the Modern Synthesis needs a serious rethink, and how a significant group of scholars is spearheading the way in this pursuit: they go under the umbrella of The Third Way of Evolution.  Tune in for this riveting discussion!

What are the big assumptions you’re making in your investment decisions? Can you list them? Is there any chance they’re WRONG? I’m Bryan Ellis. We’ll look at this serious but nearly never-discussed issue right now in Episode #310 of Self-Directed Investor Talk.----Hello, Self-Directed Investors, all across the fruited plane! Welcome to the SHOW OF RECORD for savvy self-directed investors like you.This is episode #310 of Self-Directed Investor Talk, and should you be so inclined, you’re welcomed to visit today’s show page to get a transcript and links and resources that are relevant to today’s discussion. The address for the episode #310 show page is https://SDITalk.com/310So the big question today: What are the big assumptions you’re using as a basis for your investment decisions? More importantly, is there a chance any of them are wrong?That’s a big, important question. Here’s some context for why I ask it:I’m something of a science geek. I routinely and very happily spend a relatively large amount of time learning what’s going on in the world of scientific research. One of the geekiest things that I do – and that I really love to do – is to watch formal debates that feature scientists and philosophers duking it out intellectually to see where everyone’s ideas fit in the grand scheme of things.And do you know what kind of evidence I’m seeing a LOT in the last 3 years… I mean, a LOT of it? And as I answer that question, remember that the topic of today’s show is a look at the big assumptions you’re making in your portfolio, and whether they could possibly be WRONG.So here’s what I’m seeing a lot of: I’m seeing a LOT of scientists who are absolutely the very top people in their respective fields offering very, very serious scientific resistance to the famous theory of evolution posited by Charles Darwin in the mid 1800’s. I mean, legitimate, top-tier people like the famed synthetic organic chemist Dr. James Tour at Rice University. There’s also Dr. Marcos Eberlin, the internationally renowned mass spectrometry expert at the University of Campinas in Brazil. And Michael Behe, the respected biochemist at Lehigh University. Now some people try to disregard the opinions of those guys because all of them have religious beliefs which would predispose them to resist the theory of evolution. But then you’d have to explain away highly-regarded atheistic and/or agnostic scientists and professors who also openly criticize and question Darwinian evolution like famed philosopher and mathematician Dr. David Berlinski, biologist Dr. Denis Noble at the University of Oxford, and professor Thomas Nagle at NYU. And frankly, this is only scratching the surface of dissent among serious academics and scientists of today. If you knew the extent of it all, you’d be utterly blown away.Now look, this isn’t a discussion about Darwinian evolution. Unless I have the pleasure of meeting you in person and you’d like to discuss this, then right now I don’t care what you think about that question and you need not care what I think, either.But the question is this: Can you think of any assumption that has been pounded into all of as being any more fundamental than the theory of evolution? I can’t either… and yet, whatever your position on the matter, any objective look at that theory suggests there’s a real chance that, after all of this time, the entire theory is just a crumbling house of cards. We don’t know that yet, of course, but it surely looks that way.So let’s shift that line of thinking over to our investments. Ask yourself: What are the core, operating assumptions you’re making each and every time you make an investment decision? The assumptions that are so deep that you don’t even think about them consciously?I’m thinking about this for myself, and some of them are:· Paying less tax is better than paying more tax· Making more profit is better than making less profit· Only take calculated risks· Physical assets are more secure than paper assets· Etc…Now having thought about this for a bit of time, I’m coming up with a lot of fundamental assumptions that I’m making, far more than the few I’ve mentioned here. And here’s how this becomes interesting:If considering each and every one of my fundamental assumptions, I then ask myself these questions:· Is this absolutely true?· Is this absolutely false?· Is this relatively true or relatively false, depending on the circumstances?· Is there a better assumption that I could adopt?This has been enlightening for me, my friends, for this reason: I’ve again shown myself that having extremely dogmatic rules about anything can be a very dangerous thing UNLESS you take the time to clarify not just the rule or the assumption, but also clarify what I call the two C’s: context and caveats.For example: Physical assets are, I think, more secure as an investment than paper assets. But a relevant context might be that that’s true only in an environment where it’s legal and practical to sell that asset when I need to do so, since physical items are usually not highly liquid. And a caveat to that rule might be that if owning the physical asset entails more direct, physical involvement in the asset than I am willing or able to provide, then in that case, it might make sense for me to do something like own shares in a real estate investment trust rather than owning real estate directly myself.These are simple examples, but I’ve learned a lot about myself and my assumptions I preparing for this episode… and where those assumptions may not be serving me well. Let’s you and I do our best to see to it that the only things that are crumbling are faltering scientific theories rather than our life’s savings.My friends, invest wisely today, and live well forever. See acast.com/privacy for privacy and opt-out information.

Just around the corner is the publication of Exosomes in Health and Disease, an enormous compilation of data on exosomes and their role in almost every disease you can imagine. What's an exosome, you might ask? At just a fraction of the size of even the smallest bacteria, exosomes are tiny vesicles communicating with and carrying information to cells anywhere in the body. We've known about them for decades, but a recent discovery holds huge implications for our understanding of epigenetics, epigenetic inheritance, and the causes of diseases. Denis Noble, physiologist, researcher, and former Chair of Cardiovascular Physiology at the University of Oxford joins the podcast today to offer a fascinating conversation about the presence of epigenetic data within exosomes, their ability to control the genome of other cells by simply communicating with them, and the profile components that could indicate cancer or a particular disease state. He also discusses the techniques used to extract such small vesicles from blood plasma and the challenges that this process has brought about, the transmission of epigenetic information by exosomes through the germline, symbiogenesis, and more. Tune in for all the details.

For a century, the belief was that genetic information built organisms, never the other way around. A new paper by Denis Noble definitively proves otherwise. The paper is called “Central Dogma or Central Debate.” In this interview, Denis explains the revolution that is going on in genetics. See acast.com/privacy for privacy and opt-out information.

On location in the Perigord with noise of  cockerels in the background, Denis Noble discusses with Ray Noble ideas about thinking. They start by considering the problems of dualist logic.   

What is the role of random, stochastic events in biology? How does our body react to such events? Does the presence of random events in our brains give us the illusion of freewill? Tune into this episode to hear Marty and Art talk to Denis Noble, an Emertis Professor at Oxford. Noble has written over 500 scientific articles and 11 books but may be most well known for developing the first mathematical model of heart cells in 1960. Recently, Noble published the book: “Dance to the Tune of Life,” where he notably discusses the necessity and importance of random events that occur within and between our genes, cells, tissues, and organs. --- Send in a voice message: https://anchor.fm/bigbiology/message

What is the role of random, stochastic events in biology? How does our body react to such events? Does the presence of random events in our brains give us the illusion of freewill? Tune into this episode to hear Marty and Art talk to Denis Noble, an Emertis Professor at Oxford. Noble has written over 500 scientific articles and 11 books but may be most well known for developing the first mathematical model of heart cells in 1960. Recently, Noble published the book: “Dance to the Tune of Life,” where he notably discusses the necessity and importance of random events that occur within and between our genes, cells, tissues, and organs. --- Send in a voice message: https://anchor.fm/bigbiology/message

Preconference Preview Part 3: Combating "Fake News" This week, we have another in our series of Charleston Conference preconference previews! We have an amazing group of preconference sessions that will be held on Monday and Tuesday, November 6 and 7, prior to the start of the main conference. This is the third installment in our series of preconference previews, and we’ll continue that in the future with more episodes that interview the presenters and give a little bit more background and detail on the sessions themselves. You can find registration for these sessions on the main conference registration page, and session details are available on the conference website. As a reminder, there are several applications that are open for opportunities at the conference we’d like to draw your attention to. First, the Charleston Fast Pitch Competition is looking for proposals that pitch a winning idea to improve service at an academic or research library. This contest is designed to recognize and reward new innovation in academic library and information management. The Juried Product Development Forums, or JPDF’s, are designed to offer publishers and vendors a chance to discuss new products in development, or improvements to existing products, and receive feedback from librarians and library workers. The Charleston Premiers are lightning round sessions designed to showcase new products and innovations already in the marketplace but that may not be widely known yet. Details on all of these events are available on the conference website at the links provided in the show notes. Registration for the conference is open now. Be sure to register by September 15 to receive the early bird rate – our regular and late rates have increased this year but the early bird rate stayed the same as the past few years. LINKS: Charleston Fast Pitch Competition: https://www.charlestonlibraryconference.com/fastpitch/ Juried Product Development Forums: https://www.charlestonlibraryconference.com/events/juried-product-development-forums/    Charleston Premiers: https://www.charlestonlibraryconference.com/events/charleston-premiers/  Preconference schedule with session details: https://2017charlestonconference.sched.com/ Registration for the Charleston Conference, including preconferences: https://www.charlestonlibraryconference.com/conference-registration/ On today's podcast, we’re talking with Judy Luther, Heather Staines, Lisa Janicke Hinchliffe, and Pierre Montagano who are all participants in the preconference titled “Practical Measures: Combating “Fake News” through Scholarly Integrity, Digital Literacy, and Workflow Tools.” This session will be held on Tuesday, November 7, from 8:30 am – 12:00 pm. The session will be moderated by Judy Luther, President of Informed Strategies. Professionally she’s passionate about good design of content that meets the needs of the users. Personally Judy loves being outdoors in nature and enjoy quiet moments with a good cup of tea. Pierre Montagano is the Business Development Director for Code Ocean, a Cornell Tech incubated startup. He has over 20 years’ experience in publishing but recently left to work with researchers in developing an executable code repository that helps facilities reproducibility and reuse of scientific code. Heather Staines is Director of Partnerships for Hypothesis, a non-profit open source annotation/collaboration technology, working with publishers, educators, journalists, and researchers to bring annotation to conversations anywhere on the web. She has a background in scholarly publishing and educational technology. Lisa Janicke Hinchliffe is a Professor and Coordinator for Information Literacy and affiliate faculty in the School of Information Sciences at the University of Illinois. A passionate educator, she speaks and writes frequently about library services and impact on library users. Since Judy is moderating the session, she also moderates the podcast interview.   Before we get to the interview, Katina Strauch has some updates to her “If Rumors Were Horses”  The University of North Carolina at Chapel Hill has selected the awesome Elaine L. Westbrooks, associate university librarian for research at the University of Michigan in Ann Arbor, as its new University librarian and vice provost for University Libraries. Approved by the University’s Board of Trustees, the appointment is effective Aug. 15. “Chancellor Carol Folt and I are excited to welcome Elaine to Carolina,” said Executive Vice Chancellor and Provost James W. Dean Jr. “She brings more than 19 years of higher education library experience to her role, where she will oversee one of the top-ranked university library systems in the country, including its services and more than 9 million volumes across 10 libraries.” At the University of Michigan, Westbrooks led the library’s support of the research enterprise, facilitated the management of the operations and budget. Prior to her time in Ann Arbor, Westbrooks worked at research libraries at three other universities. She served as associate dean of libraries at the University of Nebraska at Lincoln, held several positions in technical services at Cornell University Libraries and worked as a digital research and Latin American Cataloger at the University of Pittsburgh. The co-author of three books, along with several book chapters, Westbrooks lectures at numerous conferences. She also serves on the Association for Research Libraries Visioning Taskforce, was recently the chair of the HathiTrust Rights and Access Committee and also served on the HathiTrust Program Steering Committee. Westbrooks earned a bachelor of arts degree in linguistics and a master’s degree in information and library science from the University of Pittsburgh. She succeeds Sarah Michalak, who retired in December 2016. Carol Hunter, deputy University librarian and associate University librarian for collections and services, has served as interim University librarian since Michalak’s departure. She will retire from Carolina on Oct. 1. It’s been too long since we saw Bill Kane in Charleston! Bill is at Wake Forest University in the Digital Publishing Department. What a dynamo! Anyway, just got an email from Bill who has also worked at Blackwell’s and Alibris, remember? Bill was writing Beth Bernhardt, Rosann Bazirjian and yours truly to tell us that the long-retired Jack Walsdorf left us on July 9, 2017. You might remember that Jack sponsored the Rachel K. Schenck Memorial Scholarship  for the Charleston  Conference for five years (2003-2007). Jack was so generous and he knew everyone back in the day. Jack used to select a book a year to distribute at Christmas from Blackwell’s.  He also ran several evening talks on rare books way back when the Charleston Conference was in its infancy. Back then we were holding the Conference in the College of Charleston Lightsey Conference Center which has since closed and become classrooms. A Memorial Service to honor Jack is being planned to take place in the month of September. In lieu of flowers, please consider a charitable donation in Jack's memory to one of the following organizations that he himself supported:  The Lake Oswego Preservation Society: http://lakeoswegopreservationsociety.org The William Morris Society in the United States: http://www.morrissociety.org or a library of one's choice. http://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=4501&context=atg http://obits.dignitymemorial.com/dignity-memorial/obituary.aspx?n=Jack-Walsdorf&lc=7398&pid=186070273&mid=7481936 Bill also sends a link to a wonderful interview with Jack from a few years ago. http://themorrisian.blogspot.com/2013/04/the-morrisian-interview-series-2-john-j.html The incredibly resilient Chuck Hamaker sent me a link to a recent article in the Guardian – Is the staggeringly profitable business of scientific publishing bad for science?. It’s long but is a summary of much of what we in libraries have lived through over the past several decades – the growth of powerful publishing companies, rising journal costs, shrinking budget, the big deal. There are many familiar people and companies we know. Richard Charkin, Albert Henderson, Pergamon, Springer, Elsevier, John Coales, Denis Noble, Bob Houbeck, and last but not least Robert Maxwell. I remember visiting Pergamon in England hoping to get an interview, if not a glimpse of the famous man. Della Sar, Brian Cox, Inge Valentine, Bob Miranda have many reminiscences (favorable and unfavorable). I also remember -- it was during the Charleston Conference in November 5, 1991 that we learned that Maxweil had died when he fell off his yacht in the Canary Islands, leading to much speculation and autopsies. https://www.theguardian.com/science/2017/jun/27/profitable-business-scientific-publishing-bad-for-science http://www.charlestonlibraryconference.com/archives-old.php So long for now! Katina.

Interview With Denis Noble On How To Change Your Limiting Beliefs "Denis Noble (born 16 November 1936) is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of Systems Biology and developed the first viable mathematical model of the working heart in 1960" (Source: https://en.wikipedia.org/wiki/Denis_Noble) Today I've partnered up with Denis Noble to discuss about the theory of beliefs and how there is much more to that than what we already know. Biology is not what we think we know and, more and more, the scientific community is starting to see more evidence about it. In this video, Denis will show how you can change your beliefs with the power of biology and how it can directly impact your life as a software developer. Interview Perry Marshall: https://www.youtube.com/watch?v=F75GL6_ECc8 Music Of Life Book: https://simpleprogrammer.com/musicoflife Dance To The Tune Of Life Book: https://simpleprogrammer.com/themusicoflife Buy Simple Programmer SHIRT: https://store.simpleprogrammer.com/

Denis Noble is Emeritus Professor of Cardiovascular Physiology at Oxford University. He developed the first viable mathematical model of the working heart. He has been listed as one of the top 100 scientists and a pioneer in the field of Systems biology. His most recent book “The Music of Life” tackles the big issue of how biologists should seek to understand life itself. In this podcast we discuss the rhythms of life itself, the intelligence of evolution and the question of ‘self’. Guest: Connect with Denis Noble by reading The Music of Life - Biology Beyond Genes & Dance to the Tune of Life. Show Notes: • The Blind Watchmaker • Hippocampus • How trees talk to each other • Differential Equation • Rhythms of Life Conference • Oxford Trobadors • Human Genome Project • 23andME.com • The Music of Life - Biology Beyond Genes • Dance to the Tune of Life

Denis Noble CBE FRS FRCP FMedSci has a veritable alphabet soup after his name. It's kind of hard to pronounce, and it always becomes a point of conversation for him. But you don't get that many letters after your name for nothing. Noble is a longtime public intellectual, having been the first to mathematically describe the heart's pacemaker with computer models. And then the first to explain it to everyone else. “I think what we're witnessing at the moment is quite a fundamental change in the way in which biology is viewed,” says Noble. He goes into further detail. Most people think of our origins as a species to be “solved,” to be “all sorted out.” In fact, the theory of evolution is just that: a theory. There is still late-breaking news in gene mutation and selection in the field. There's still a lot to figure out. Tune in to hear more of Denis Noble's insights. Subscribe, review, and if you can, consider donating some BitCoin to the cause. Every little bit helps.

In this second dialogue, Denis Noble, author of Dance to the Tune of LIfe, discusses whether there can be purpose and direction in evolution. 

Thin End discusses with Professor Denis Noble his new book Dance to the Tune of Life and new ideas on evolution. 

Mis on elu? Tunnustatud füsioloog ja üks süsteemibioloogia rajajatest Denis Noble püüab selles väga isiklikus ja kohati sügavalt poeetilises raamatus vastata just sellele küsimusele. Autor väidab, et elu alusküsimustele vastuste saamiseks tuleb meil vaadata kaugemale, kui võimaldab pelgalt geenikeskne vaade bioloogiale. Mõistmaks elu olemust, tuleb meil uurida elu paljudel tasanditel korraga. Sel juhul avaldub elu protsessina, mis tuksleb kõiki neid tasandeid siduvas võrgustikus. Just see, väidab Noble, on elu muusika. (Denis Noble. Elu muusika. Bioloogia teispool geene.)

A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

Cycle Penser le vivant, conférence du 6 octobre 2012. Génétique, biologie du développement, neurosciences : qu'est-ce que le vivant ? Qu'est ce que l'être humain ? Ces rencontres, réunissant à chaque fois deux spécialistes, nous aideront à entrer dans ce monde en pleine effervescence. Cycle conçu et présenté par Roland Schaer, philosophe. Avec le soutien de la Fondation Simone et Cino Del Duca, Institut de France

Cycle Penser le vivant, conférence du 6 octobre 2012. Génétique, biologie du développement, neurosciences : qu'est-ce que le vivant ? Qu'est ce que l'être humain ? Ces rencontres, réunissant à chaque fois deux spécialistes, nous aideront à entrer dans ce monde en pleine effervescence. Cycle conçu et présenté par Roland Schaer, philosophe. Avec le soutien de la Fondation Simone et Cino Del Duca, Institut de France