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In this podcast, Vicente Planelles, PhD, from the University of Utah School of Medicine, discusses his recently published research "Sex influences SAMHD1 activity and susceptibility to HIV-1 in primary human macrophages." Read more here:https://www.consultant360.com/podcast/infectious-diseases/hivaids/vicente-planelles-phd-gender-influences-samhd1-activity.
Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ned Landau Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference TWiV #124 September 2008 SAMHD1 restricts HIV-1 replication (Nature) SAMHD1 restricts diverse retroviruses (Retrovirology) Vpx degradation of SAMHD1 independent of uncoating (J Virol) Transduction of myeloid cells with Vpx vector (Gene Ther) Letters read on TWiV 511 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne- Online Immunology Course Alan- Bacteria Builder Rich- 2018 Ig Nobel Prizes Dickson- Between Fear and Hope Ned - HUSH silencing of transposons Vincent - Paywall publishing ban (Schlitz statement); Curry on DORA Listener Pick Steve- Paywall: Business of Scholarship and Biohazard Islam- Peer review Twitter post Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
Philippe Pasero, Institute of Human Genetics, Montpellier, speaks on "SAMHD1 processes stalled forks and links DNA replication stress to inflammation". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.
Hosts: Vincent Racaniello and Rich Condit Guest: Michael Emerman Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis. Links for this episode: Ancient origins of SIV (PLoS Path) Paleovirology (PLoS Biology) Harmit Malik on TWiV 205 Sara Sawyer on TWiV 193 Listener Pick of the Week Molly - Facts in the case of Dr. Andrew Wakefield Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
AUGUST 2010: Discussion of Aicardi-Goutières Syndrome and SAMHD1
Authors Professor Yanick J Crow(Prof of Genetic Medicine, Manchester University) and Dr Vijeya Ganesan(Senior Lecturer at the Institute of Child Health, London, and Consultant at Great Ormond Street Hospital, London) discuss the bacground of Aicardi-Goutières syndrome and the most recently idenitfied gene, SAMHD1 with Editor In Chief of Developmental Medicine and Child Neurology, Dr Peter Baxter. Please see below for a link to the paper: Intracerebral large artery disease in Aicardi–Goutières syndrome implicates SAMHD1 in vascular homeostasis (p 725-732) VENKATESWARAN RAMESH, BRUNO BERNARDI, ALTIN STAFA, CATERINA GARONE, EMILIO FRANZONI, MARIO ABINUN, PATRICK MITCHELL, DIPAYAN MITRA, MARK FRISWELL, JOHN NELSON, STAVIT A SHALEV, GILLIAN I RICE, HANNAH GORNALL, MARCIN SZYNKIEWICZ, FRANÇOIS AYMARD, VIJEYA GANESAN, JULIE PRENDIVILLE, JOHN H LIVINGSTON, YANICK J CROW PDF: http://www3.interscience.wiley.com/cgi-bin/fulltext/123580141/PDFSTART
Authors Professor Yanick J Crow(Prof of Genetic Medicine, Manchester University) and Dr Vijeya Ganesan(Senior Lecturer at the Institute of Child Health, London, and Consultant at Great Ormond Street Hospital, London) discuss the bacground of Aicardi-Goutières syndrome and the most recently idenitfied gene, SAMHD1 with Editor In Chief of Developmental Medicine and Child Neurology, Dr Peter Baxter. Please see below for a link to the paper: Intracerebral large artery disease in Aicardi–Goutières syndrome implicates SAMHD1 in vascular homeostasis (p 725-732) VENKATESWARAN RAMESH, BRUNO BERNARDI, ALTIN STAFA, CATERINA GARONE, EMILIO FRANZONI, MARIO ABINUN, PATRICK MITCHELL, DIPAYAN MITRA, MARK FRISWELL, JOHN NELSON, STAVIT A SHALEV, GILLIAN I RICE, HANNAH GORNALL, MARCIN SZYNKIEWICZ, FRANÇOIS AYMARD, VIJEYA GANESAN, JULIE PRENDIVILLE, JOHN H LIVINGSTON, YANICK J CROW PDF: http://www3.interscience.wiley.com/cgi-bin/fulltext/123580141/PDFSTART