Podcasts about Immunodeficiency

Dr. Rik Mehta, Co-Founder of Lactiga, joins EisnerAmper's TechTalk host Fritz Spencer to discuss how his biotech startup is pioneering the development of the first mucosal antibodies to treat the unmet medical needs of immunodeficient patients. In this episode, discover how Lactiga is unlocking the full therapeutic value of human milk to create this next generation of anti-infectives. Tune in to learn more about the startup's mission to give immunodeficient patients a new line of defense against pathogens, significantly improving their quality of life and offering hope for a healthier future.

JACI: In Practice Editor Robert Zeiger describes the January issue, the theme of which is “Insect Sting Allergy”. Theme topics covered include venom component allergen IgE measurement, risk factors for severe sting reactions and side effects during venom immunotherapy, stinging ant anaphylaxis, mast cell disorders and hymenoptera venom-triggered anaphylaxis, large local reaction to insect stings, and shared decision making in the diagnosis and management of insect sting allergy. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Insect Sting Allergy, Asthma, Drug Allergy, Eosinophilic Disorders, Food Allergy, Immunodeficiency, Mast Cell Disorders, and Urticaria

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Severe Combined Immunodeficiency Disorder (SCID) ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Immunology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

JACI: In Practice Editor Scott Sicherer describes the September issue, the theme of which is “Contact Dermatitis.” Theme topics covered include various aspects of the diagnosis and management of cutaneous contact dermatitis; contact dermatitis from biomedical devices, implants, and metals; and delayed skin testing for systemic medications. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Anaphylaxis, Asthma, Drug Allergy, Eosinophilic Disorders, Food Allergy, and Immunodeficiency.

Today, we have the honor of speaking once again with Sheila Ames, a registered nurse in Northern California who has been diagnosed with a rare type of a primary immunodeficiency known as common variable immunodeficiency or CVID for short. How did she fare during the recent Pandemic?  Tune in now to find out! At the time of her diagnosis she was working as an ICU nurse and her first doctors order was: no more exposure to infectious patients.  This diagnosis not only changed her career dramatically, it led her to following her life's purpose in opening her own health & wellness online coaching business to help others continue to find and work towards their life's purpose despite the hurdles that life gives us. ​Common variable immunodeficiency (CVID) is a primary immune deficiency disease characterized by low levels of protective antibodies and an increased risk of infections. Although the disease usually is diagnosed in adults, it also can occur in children. CVID also is known as hypogammaglobulinemia, adult-onset agammaglobulinemia, late-onset hypogammaglobulinemia, and acquired agammaglobulinemia. NIAID supports research to determine genetic causes of CVID that may lead to therapeutic approaches to address the disease. Researchers also are exploring how antibody-based drugs may lessen the severity of the condition. ​Causes CVID is caused by a variety of different genetic abnormalities that result in a defect in the capability of immune cells to produce normal amounts of all types of antibodies. Only a few of these defects have been identified, and the cause of most cases of CVID is unknown. Many people with CVID carry a DNA variation called a polymorphism in a gene known as TACI. However, while this genetic abnormality confers increased risk of developing CVID, it alone is not capable of causing CVID. CVID is also linked to IgA deficiency, a related condition in which only the level of the antibody immunoglobulin A (IgA) is low, while levels of other antibody types are usually normal or near normal. IgA deficiency typically occurs alone, but in some cases it may precede the development of CVID or occur in family members of CVID patients. ​Symptoms & Diagnosis People with CVID may experience frequent bacterial and viral infections of the upper airway, sinuses, and lungs. Acute lung infections can cause pneumonia, and long-term lung infections may cause a chronic form of bronchitis known as bronchiectasis, which is characterized by thickened airway walls colonized by bacteria.   People with CVID also may have diarrhea, problems absorbing food nutrients, reduced liver function, and impaired blood flow to the liver. Autoimmune problems that cause reduced levels of blood cells or platelets also may occur. People with CVID may develop an enlarged spleen and swollen glands or lymph nodes, as well as painful swollen joints in the knee, ankle, elbow, or wrist. In addition, people with CVID may have an increased risk of developing some cancers. Doctors can diagnose CVID by weighing factors including infection history, digestive symptoms, lab tests showing very low immunoglobulin levels, and low antibody responses to immunization. ​Treatment CVID is treated with intravenous immunoglobulin infusions or subcutaneous (under the skin) immunoglobulin injection to partially restore immunoglobulin levels. The immunoglobulin given by either method provides antibodies from the blood of healthy donors. The frequent bacterial infections experienced by people with CVID are treated with antibiotics. Other problems caused by CVID may require additional, tailored treatments. To learn more about CVID, visit the National Library of Medicine, Genetics Home Reference CVID site  (Credits to NIH) ​ If you would like to reach out to our guest: Sheila Ames BSN, RN, PHN Holistic Health Coach Business FB page:  https://www.facebook.com/JourneyIntoWellness1 ​PID (primary immunodeficiency) group:  https://www.facebook.com/groups/journeyintowellnesspid ​Instagram:  @journeyintowellnesscoaching My website:  journeyintowellness.net

JACI: In Practice Editor Scott Sicherer describes the July issue, the theme of which is “Prevention of Allergy and Asthma,”. Theme topics covered include prevention of food allergy, atopic dermatitis, and asthma. The issue also contains an American Academy of Allergy Asthma and Immunology Work Group Report on the subject of “The Impact of Prior Authorization on Clinical Practice and Patient Care Outcomes”. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Drug Allergy, Food Allergy, Immunodeficiency, Mast Cell Disorders, Rhinitis, and Urticaria.

JACI: In Practice Editor David Khan describes the June issue, the theme of which is “Allergic and Nonallergic Rhinitis.” Theme topics covered include allergic rhinitis, including immunotherapy and local allergic rhinitis; non-allergic rhinopathy; the impact of social determinants of health and climate change on chronic rhinitis; and evaluation of patients presenting with nasal congestion or post nasal drip. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Rhinitis, Asthma, Dermatitis, Drug Allergy, Food Allergy, Hereditary Angioedema, and Immunodeficiency.

In this week's episode we'll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency.Featured Articles:Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talkStaphylococcus aureus induces drug resistance in cancer T cells in Sézary syndromeClinical and functional spectrum of RAC2-related immunodeficiency

Through sharing her own story publicly, Catherine learned the importance of disability representation and advocacy for young people. She also delves into why it is crucial to include the voices of young adults in the research and advocacy process. Cheryl and Catherine explore the process of dismantling their own internalized ableism and challenging societal norms around what constitutes a "normal" life. They also challenge the idea that disability is necessarily a “bad” word.  They emphasize the importance of self-care and finding joy in everyday activities, even if they require accommodation. For Catherine, participating in activities like surfing, albeit in an accommodated manner, brings fulfillment and contributes to her definition of living a good life with chronic illness. Throughout the conversation, Cheryl and Catherine underscore the values of self-advocacy, self-acceptance, and finding happiness on one's own terms.Medical disclaimer: All content found on Arthritis Life public channels was created for generalized informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.Episode SponsorsRheum to THRIVE, an online course and support program Cheryl created to help people with rheumatic disease go from overwhelmed, confused and alone to confident, supported and connected. See all the details and join the program or waitlist now! For full episode detailsFor full episode details including hyperlinks to things discussed on this episode, go to the episode page on the Arthritis Life website. 

Human Immunodeficiency Virus (HIV) is a chronic illness that disproportionately affects the Veteran community. In this episode of the PTSD Bytes podcast, Dr. Hemmy discusses risk factors for contracting HIV, challenges after receiving a positive diagnosis, and tips for people who have both HIV and PTSD to help navigate treatment.Closed Caption Transcript is available at: https://www.sharedfedtraining.org/Podcasts/PTSDBytes_EP37.pdf ===============================

JACI: In Practice Editor Michael Schatz describes the April issue, the theme of which is “Newer Approaches to Asthma Management”. Theme topics covered include phenotyping severe asthma in the current era of biologics, management of extrapulmonary treatable traits, downstream impacts of systemic inflammation in patients with asthma, the relationship to asthma and therapeutic potential of alterations in the respiratory and gut microbiome, the new paradigm of inhaled corticosteroid use as part of reliever therapy, and the recently articulated goal of achieving disease remission. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Drug Allergy, Eosinophilic disorders, Food Allergy, Hereditary Angioedema, Immunodeficiency, and Rhinosinusitis.

JACI: In Practice Editor Scott Sicherer describes the March issue, the theme of which is “Food Allergy”. Theme topics covered include food allergy immunotherapy, biologics in the treatment of food allergy, addressing health equity in food allergy, sesame allergy, and pollen food allergy syndrome to nuts. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Food Allergy, Asthma, Drug Allergy, Eosinophilic Disorders, Hereditary Angioedema, Immunodeficiency, and Mast Cell Disorders. 

Blood is a symbol of life, which makes sense given that it plays such an important role in so many body functions, including our immune system. Blood makes up approximately 8% of your normal body weight and unfortunately, cancers of the blood, including lymphoma and leukemia, account for ~10% of all diagnosed cancers in the U.S. each year.  CAR-T cell therapy has emerged as a promising method to engineer a subject's own immune cells to fight bloodborne cancer. Our guest for this episode, Raquel Munoz from the Hospital Universitario Virgen del Rocío in Seville Spain, is doing research in this exciting CAR-T cell therapy space. Specifically, she is working to develop methods to help better quantify and understand the expansion of CAR-T cells in the body to help monitor treatment and predict outcomes.  We learn about why digital PCR was selected for her work and how it's helped raise confidence in the results they're getting. We even hear about how she believes this treatment will find success in treating solid tumor cancers.In Cassie's career corner, we learn how Raquel found her career path and love of immunology and working in a hospital setting. Raquel also shares some great career advice, stories of lab mishaps, and the dangerous hobby that she says is some of the only time she's not thinking about work or problems. Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Pig virus imperils food security in Borneo (Science) Measles outbreaks in UK and Europe (Nature) Fatal Nipah virus infections in Bangladesh (CIDRAP) Yellow fever outbreak in Sudan (Crisis24) COVID-19 influenced by type of immunodeficiency (Sci Transl Med) Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe) Letters read on TWiV 1085 Timestamps by Jolene. Thanks! Weekly Picks Dickson – JWST details of 19 spiral galactic centers Rich – Great White Shark Attack And Breach Vincent – Black History Month and Lost Photographs of Black America Listener Picks Louise – The Mystery Of The Village That Beat The Black Death Pierre – Three things airlines don't want you to know Brandon – Professor Dave explains Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

My links: My patreon: ⁠https://www.patreon.com/user?u=103280827 My Ko-fi: https://ko-fi.com/rhetoricrevolution Send me a voice message!: https://podcasters.spotify.com/pod/show/liam-connerly TikTok: ⁠https://www.tiktok.com/@mrconnerly?is_from_webapp=1&sender_device=pc⁠ Email: ⁠rhetoricrevolution@gmail.com⁠ Instagram: https://www.instagram.com/connerlyliam/ Podcast | Latin in Layman's - A Rhetoric Revolution https://open.spotify.com/show/0EjiYFx1K4lwfykjf5jApM?si=b871da6367d74d92 The Greek word "phylax" (φύλαξ), meaning "watcher, guard, sentinel, guardian, keeper, protector," has woven its way into the very fabric of the English language, offering us a rich tapestry of words relating to protection, observation, and defense. Let's delve into some of these fascinating linguistic gems: Direct Derivatives: Phylactic: (adjective) Protective, preserving, tending to guard against disease or harmful influences. (e.g., Phylactic measures implemented during a pandemic) Aphylaxis: (noun) The absence of natural defenses against disease or pathogens. (e.g., Immunodeficiency disorders cause aphaxia) Prophylaxis: (noun) Preventive measures taken to protect against disease or infection. (e.g., Vaccinations are a form of prophylaxis) Phylactocarp: (noun) A type of fruit with a tough outer covering that protects the seeds inside. (e.g., Walnuts are phylactocarps) Phylactolaematous: (adjective) Describing a group of aquatic mosses with protective capsules enclosing their reproductive organs. Extended Family: Protectorate: (noun) A country under the protection of another, usually more powerful, country. (e.g., The British Protectorate of North Borneo) Sheriff: (noun) A high-ranking law enforcement officer in a county or region. (Etymology: Old English "scirerefa," meaning "shire-reeve" - guardian of the shire) Philanthropy: (noun) The love of humanity, manifested in charitable acts. (Etymology: "philos" - loving, "anthropos" - human) Phylar: (noun) A leader of a tribe or clan, often associated with military duties. (e.g., In ancient Sparta, the Phylarchoi led the Moirai) Phylary: (noun) A tribe or clan, especially in ancient Greece. (e.g., The Athenians were divided into phylai) Fiancé(e): (noun) A person to whom one is engaged to be married. (Etymology: French "fié(e)," from Latin "fidare" - to trust) Spy: (noun) A person employed to secretly obtain information on an enemy or rival. (Etymology: Old French "espier," possibly from Latin "specere" - to look) Metaphorical Extensions: Safeguard: (verb) To protect or keep something safe from harm. (Metaphor: A guard standing before a safe) Shelter: (noun) A place providing protection from danger or bad weather. (Metaphor: A roof sheltering people from the rain) Vigilance: (noun) The state of keeping watchful and alert. (Metaphor: A sleepless guard vigilant against enemies) Defend: (verb) To protect someone or something from attack or harm. (Metaphor: A warrior defending a castle) Etymology in Action: Phylactic: The "k" at the end is a remnant of the Greek suffix "-ikos," meaning "of or relating to." Therefore, phylactic translates to "of or relating to a guard or protector." Philanthropy: The word combines "philos" (loving) and "anthropos" (human), literally meaning "love of humanity." This reflects the underlying principle of caring for and protecting one's fellow humans. Sheriff: The journey from "phylarch" to "sheriff" shows how language adapts over time. The Old English "scirerefa" directly translates to "shire-reeve," showcasing the historical role of a sheriff as the guardian of a shire (an administrative division).

JACI: In Practice Editor Robert Zeiger describes the January issue, the theme of which is “Inhalant Allergen Immunotherapy”. Theme topics covered include the art of immunotherapy, allergen immunotherapy for asthma, allergen immunotherapy for allergic rhinitis, impact of allergen immunotherapy on the progression of airway disease, and mechanisms and predictive biomarkers of allergen immunotherapy. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Immunotherapy, Anaphylaxis, Artificial Intelligence, Asthma, Drug Allergy, Food Allergy, Immunodeficiency, and Urticaria and Angioedema. 

This podcast episode examines the need for and promise of xenotransplantation, considering first the plight of patients and then the progress being made by researchers. . Is Xenotransplantation Ready for Prime Time? N Engl J Med 2023;389:e49.

References Front Immunol. 2023; 14: 1151166 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

JACI: In Practice Editor Dave Khan describes the November issue, the theme of which is “COVID-19 and Allergy/Immunology”. Theme topics covered include the impact of COVID-19 on common allergic diseases, COVID-19 vaccine reactions, COVID-19 treatments, long COVID, social determinants of health and COVID-19, social media and COVID-19, physician and patient wellness during the pandemic, and preparing the allergist/immunologist for the next pandemic. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of COVID-19, Anaphylaxis, Asthma,  Drug Allergy, Food Allergy, Immunodeficiency, Rhinosinusitis, and Urticaria

JACI: In Practice Editor Michael Schatz describes the September issue, the theme of which is “Biologics”. Theme topics covered include the use of biologics for asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, and hypereosinophilic syndromes. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of Biologics, Asthma, Dermatitis, Drug Allergy, Eosinophilic Disorders, Food Allergy, Immunodeficiency, Immunotherapy, Insect Sting Allergy, and Urticaria.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Common Variable Immunodeficiency Disorder (CVID) ⁠⁠from the Pediatrics section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

August 2023 Podcast DescriptionJACI: In Practice Editor Dave Khan describes the August issue, the theme of which is “Focus on Urticaria and Angioedema”. Theme topics covered include masqueraders and misdiagnoses, genetic variants and biomarkers, autoreactivity and autoimmunity, treatment beyond antihistamines and biologics, cold urticaria, angioedema with normal complement studies, and hereditary angioedema. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Urticaria and Angioedema, Asthma, Dermatitis, Eosinophilic Disorders, Food Allergy, Immunodeficiency, Mast Cell Disorders, Rhinitis and Sinusitis, and Topics in Quality Improvement and Patient Safety.

Dr Shane and Chris KP geek out over astrophysics with Prof. Virginia Kilborn and Dr Suzie Sheehy. Who discuss what makes up a galaxy and address the exciting question - do dark galaxies exist?Then Dr Emily Edwards and Johanna B Kelly discuss newborn screening. World class standard is to test for 80 diseases in the newborn heel prick test. In Australia we currently test for 28, as we haven't updated our testing since the 1990s. Labor confirmed their election promise of $38.4 million on April 6th 2022, to “end the testing lottery” of our very outdated Newborn Screening policy. Unfortunately, a federal budget senate hearing announced that Labor is no longer implementing this world class national newborn screening program of 80 diseases, budgeted for rollout in 2023.Program page: Einstein-A-Go-GoFacebook page: Einstein-A-Go-GoTwitter: Einstein-A-Go-Go

This week the fellas are joined by Aubrey, a young adult living with Common Variable Immunodeficiency (CVID) and Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD), as she shares her journey of resilience. From symptoms to diagnosis and treatment, we explore the world of Primary Immunodeficiencies (PI) and the importance of plasma donations for PI patients. Aubrey candidly discusses her college experience with chronic illness and the uncertainties it brings to future plans. We also delve into the crucial topic of mental health and how Aubrey manages anxiety and depression. Dating and friendships as a young adult with an invisible illness are explored, shedding light on disclosure, relationship dynamics, and finding supportive partners. Don't miss this empowering conversation that offers practical insights into living a fulfilling life despite the challenges of chronic illness. Join the post-episode conversation over on Discord! https://discord.gg/expeUDN

This week the fellas are joined by Aubrey, a young adult living with Common Variable Immunodeficiency (CVID) and Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD), as she shares her journey of resilience. From symptoms to diagnosis and treatment, we explore the world of Primary Immunodeficiencies (PI) and the importance of plasma donations for PI patients. Aubrey candidly discusses her college experience with chronic illness and the uncertainties it brings to future plans. We also delve into the crucial topic of mental health and how Aubrey manages anxiety and depression. Dating and friendships as a young adult with an invisible illness are explored, shedding light on disclosure, relationship dynamics, and finding supportive partners. Don't miss this empowering conversation that offers practical insights into living a fulfilling life despite the challenges of chronic illness. Join the post-episode conversation over on Discord! https://discord.gg/expeUDN

JACI: In Practice Deputy Editor Robert Zeiger describes the June issue, the theme of which is “Immunodeficiency”. Theme topics include the genetics, diagnosis, management, and complications of various types of inborn errors of immunity and related disorders. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Immunodeficiency, Allergic Bronchopulmonary Aspergillosis, Asthma, Drug Allergy, and Food Allergy. 

JACI: In Practice Deputy Editor Scott Sicherer describes the April issue, the theme of which is “Difficult Decisions in Food Allergy”. Theme topics covered include precautionary allergen labeling, oral food challenges, immunotherapy, and epinephrine treatment. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Food Allergy, Anaphylaxis, Asthma, Drug Allergy, Hereditary Angioedema, Immunodeficiency, Rhinitis, and Urticaria.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.01.535193v1?rss=1 Authors: Huang, Y., Abdelgawad, A. G. A., Turchinovich, A., Queen, S., Abreu, C. M., Zhu, X., Batish, M., Zheng, L., Witwer, K. W. Abstract: Introduction: Antiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Extracellular vesicle (EV) RNAs have emerged as important participants in HIV disease pathogenesis. Brain tissue-derived EVs (bdEVs) act locally in the source tissue and may indicate molecular mechanisms in HIV CNS pathology. Using brain tissue and bdEVs from the simian immunodeficiency virus (SIV) model of HIV disease, we profiled messenger RNAs (mRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), seeking to identify possible networks of RNA interaction in SIV infection and neuroinflammation. Methods: Postmortem occipital cortex tissues were obtained from pigtailed macaques either not infected or dual-inoculated with SIV swarm B670 and clone SIV/17E-Fr. SIV-inoculated groups included samples collected at different time points during acute infection or chronic infection without or with CNS pathology (CP- or CP+). bdEVs were separated and characterized in accordance with international consensus standards. RNAs from bdEVs and source tissue were used for sequencing and qPCR to detect mRNA, miRNA, and circRNA levels. Results: Multiple dysregulated bdEV RNAs, including mRNAs, miRNAs, and circRNAs, were identified in acute and CP+. Most dysregulated mRNAs in bdEVs reflected dysregulation in their source tissues. These mRNAs are disproportionately involved in inflammation and immune responses, especially interferon pathways. For miRNAs, qPCR assays confirmed the differential abundance of miR-19a-3p, let-7a-5p, and miR-29a-3p (acute phase), and miR-146a-5p and miR-449a-5p (CP+) in bdEVs. In addition, target prediction suggested that several circRNAs that were differentially abundant in source tissue might be responsible for specific differences in small RNA levels in bdEVs during SIV infection. Conclusions: RNA profiling of bdEVs and source tissues reveals potential regulatory networks in SIV infection and SIV-related CNS pathology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol) •Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) •Letters read on TWiV 993 •Timestamps by Jolene. Thanks! Weekly Picks Brianne – Xkcd: Lymphocytes Kathy – A brief history of Parafilm with video Alan – Mapping and exploring the USS Monitor wreck Vincent – Skype a Scientist Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Matthew W. Ryan, MD, and Cecelia Damask, DO, share their insights on clinical presentations, laboratory evaluations, and treatment options regarding immunodeficiencies, during the podcast, “Immunodeficiency,” which was commissioned by the Allergy, Asthma, and Immunology Committee. 

If you had to reflect on your life, what would be your defining moment? For Harper Spero, it was walking in NYC one day and, out of the blue, being unable to breathe. Harper has a rare Immunodeficiency called hyper IGE syndrome (there are only 300 people diagnosed in the world) and, after a life-altering surgery, decided to change the entire trajectory of her career. "The doctor said, 'You have a cyst the size of a golf ball in your right lung, and you need surgery immediately to remove it.' Everything about my life is before that call and after that call. It was such a defining moment." After the surgery, Harper realized that she needed to prioritize her health and mental well-being, which led her to leave her job in the beauty industry and explore other career options. She eventually found a job with a boss who prioritized personal development and wellness, which gave her the accommodations she needed to take care of herself. It was that role and a chance meeting that would lead to her discovering her love of coaching. After completing her certification in 2014 to become a professional coach, today Harper supports solopreneurs and small business owners in brainstorming, launching, and building their businesses. She is often referred to as the external COO/CMO of her client's businesses. In 2018, after years of not finding content related to her rare condition that resonated with her, Harper launched Made Visible, a podcast that amplifies the stories of people living with or affected by invisible illness. In 2020, she began facilitating writing classes for the Made Visible community to give them a safe place to share, feel more seen and heard, and learn from established authors. She is working with companies to create content, community, and inclusivity amongst employees living with invisible illnesses to have and experience support from their employers. In this episode, Harper and I discuss what it means to have health get in the way of a career and why it's imperative to prioritize and advocate for yourself in the workplace. We also dive into Harper's superior skills in making authentic connections, writing a compelling pitch, how she never fails to meet a deadline or a follow-up, and so much more.

$5 Q-BANK: https://www.patreon.com/highyieldfamilymedicine Intro 0:30, Selective IgA deficiency 1:30, Bruton's agammaglobulinemia 3:27, Transient hypogammaglobulinemia 4:47, Hyper IgM syndrome 5:45, Common variable immunodeficiency (CVID) 6:52, Severe combined immunodeficiency (SCID) 8:17, DiGeorge syndrome 10:58, Ataxia telangiectasia 13:21, Wiskott-Aldrich syndrome 14:54, Hyper IgE syndrome 16:02, Leukocyte adhesion deficiency 18:04, Chediak-Higashi syndrome 19:11, Chronic granulomatous disease 20:09,  Complement deficiencies 21:56, Leukemia and lymphoma 23:40, Secondary immunodeficiencies 25:25, Practice questions 27:22

It took a lot of research, but I found some pretty incredible herbs for AIDS. Check this out. Dr. Berg's Keto and IF Lab: https://www.facebook.com/groups/drbergslab/ How to Bulletproof your Immune System FREE Course: https://bit.ly/39Ry3s2 FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Find Your Body Type: https://www.drberg.com/body-type-quiz Talk to a Product Advisor to find the best product for you! Call 1-540-299-1557 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8 am - 6 pm and Saturday 9 am - 5 pm EST. At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C Pinterest: https://www.pinterest.com/drericberg/

Luke 19:11-27 27 But bring here those enemies of mine, who did not want me to reign over them, and slay them before me. Matthew 25:14-30  14 “For the kingdom of heaven is like a man traveling to a far country, who called his own servants and delivered his goods to them.

In this episode, we chat with Viraj Mane, PhD, co-founder and chief scientific officer of Lactiga. Lactiga is a Toronto-based biotech company that has developed and patented methods of extracting antibodies from human breast milk to develop treatments for immunodeficient patients. Viraj discusses Lactiga, research on novel therapeutics to combat COVID, achieving work-life balance, advice for aspiring founders and more.  For more information about Fusemachines, please visit our website at https://www.fusemachines.comFor more information about Lactiga, please visit https://lactiga.comMusic: Welcome to the Show by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4614-welcome-to-the-show License: https://filmmusic.io/standard-license

JACI: In Practice Deputy Editor Robert Zeiger describes the July 2022 issue, the theme of which is “Immunogenetics for the Allergy/Immunology Clinician.” Theme topics covered include office genetic testing, immunogenomics and drug hypersensitivity, genetics of complement deficiencies, inborn errors of immunity with cancer predisposition, and the genetics of allergic diseases. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Immunodeficiency, Angioedema, Asthma, Drug Allergy, Eosinophilic Disorders, Food Allergy, and Rhinitis and Sinusitis. Read the issue: https://bit.ly/JAIPJuly2022Access JACI: In Practice's entire library: https://www.jaci-inpractice.org   

5 states that have the highest rate of aids

Dr. Hailey Eddington is a board certified Naturopathic Doctor, Board Certified Functional Health Practitioner

In this episode, we review the high-yield topic of Common Variable Immunodeficiency Disorder from the Immunology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficialx Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

JACI: In Practice Associate Editor, David Khan, describes the April issue, the theme of which is “Health Disparities in Asthma and Allergy.” Theme topics covered include Methods for Cross-Cultural Communication in Clinic Encounters, The Magnification of Health Disparities During the COVID-19 Pandemic, Physician Advocacy in Achieving Health Equity, Health Disparities Education Among Trainees and Physicians, Increasing Representation of Historically Marginalized Populations in Research Studies, Asian American Patients with Allergic Diseases, and Social Determinants of Health in Asthma. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Health Disparities, Angioedema, Asthma, Drug Allergy, Food Allergy, Immunodeficiency, and Rhinosinusitis. Read the issue: https://bit.ly/JAIPApril2022. Access JACI: In Practice's entire library: https://www.jaci-inpractice.org   

A cquired immunodeficiency syndrome (AIDS) Awas first reported in 1981 in'homosexual men. AIDS is a retroviral disease caused by human immunodeficiency virus (HlV). The disease is characterized by immunosuppression, secondary neoplasma and neurological manifestations. AIDS is invariably fatal since there is no cure. In the USA, it is the fourth leading cause of death in men between the ages 15 to 55 years. No other disease has attracted as much aftention as AIDS by the governments, public and scientists. AIDS has stimulated an unprecedented amount of biomedical research which led to a major understanding ofthis deadfy disease within a short period of time. So rapid is the research on AIDS (particularly relating to molecular biofogy), any review is destined to be out of date by the time it is published! The isolation of human immunodeficiency virus (HIV) from lymphocytes of AIDS patients was independently achieved by Gallo (USA) and Montagnier (France) in 1984. Epidemiology AIDS was first described in USA and this country has the majority of reported cases. The prevalence of AIDS has been reported from almost every country. The number of people living with HfV worldwide is estimated to be around 40 million by the end of the year 2005. (lndia alone has about 5 million persons). At least 5 million deaths occurred in 2005, due to AIDS. AIDS is truely a global disease with an alarming increase in almost every country. Transmission of HIV : Transmission of AIDS essentially requires the exchange of body fluids (semen, vaginal secretions, blood, milk) containing the virus or virus-infected celfs. There are three major routes of HIV transmission- sexual contact, parenteral inoculation, and from infected mothers to their newborns. The distribution of risk factors for AIDS trans- mission are as follows. Sex between men (homosexuals) Sex between men and women - 60"/" -15%Intravenous drug abusers - 15"/" Transfusion of blood and blood products - 6% All others - 4o/o The predominant methods of HIV transmission (about 75o/") are through anal or vaginal intercourse. The risk for the transmission is much higher with anal than with vaginal intercourse. The practice of 'needle sharing' is mainly responsible for the transmission of HIV in drug abusers. Pediatric AIDS is mostly caused by vertical transmission (mother to infant). It should, however, be noted that HIV cannot be transmitted by casual personal contact in the household or work place. Further, the transmission of AIDS from an infected individual to health personnel attending on him is extremelv rAre. Virology of HIV AIDS is caused by a retrovirus, namely human immunodeficiency virus (HlY), belonging to lentivirus family. Retroviruses contain RNA as the genetic material. On entry into the host cell, they transcribe DNA which is a complementary copy of RNA. The DNA, in turn is used, as a template to produce new viral RNA copies. Two different forms of HlV, namely HIV-I and HIV-2 have been isolated from AIDS patients. HIV-1 is more common, being found in AIDS patients of USA, Canada, Europe and Central Africa while HIV-2 is mainly found in West Africa. Both the viruses are almost similar except they differ in certain immunological properties. HIV-1 is described in some detail. Structure of HIV : The viruse is spherical with a diameter of about 110 nm. lt contains a core, surrounded by a lipid envelop derived from the host pfasma membrane (Fig.3fl.l). The core of the HIV has two strands of genomic RNA and four core proteins, PZq, PtB, reverse tranScriptase (poolpsr) and endonuclease (p32). Note that the naming of the proteins is based on the molecular weight. For instance, a protein with a molecular weight of 24,0OO is designated as p2,4. The lipid membrane of the virus is studded with two glycoproteins Bprzo and gpot. The surface antigen 8p126 is very important for the viral infection CD4.

We have the honor of speaking once again with Sheila Ames, a registered nurse in Northern California who has been diagnosed with a rare type of a primary immunodeficiency known as common variable immunodeficiency or CVID for short.  At the time of her diagnosis she was working as an ICU nurse and her first doctors order was: no more exposure to infectious patients.  This diagnosis not only changed her career dramatically, it led her to following her life's purpose in opening her own health & wellness online coaching business to help others continue to find and work towards their life's purpose despite the hurdles that life gives us. ​Common variable immunodeficiency (CVID) is a primary immune deficiency disease characterized by low levels of protective antibodies and an increased risk of infections. Although the disease usually is diagnosed in adults, it also can occur in children. CVID also is known as hypogammaglobulinemia, adult-onset agammaglobulinemia, late-onset hypogammaglobulinemia, and acquired agammaglobulinemia. NIAID supports research to determine genetic causes of CVID that may lead to therapeutic approaches to address the disease. Researchers also are exploring how antibody-based drugs may lessen the severity of the condition. ​Causes CVID is caused by a variety of different genetic abnormalities that result in a defect in the capability of immune cells to produce normal amounts of all types of antibodies. Only a few of these defects have been identified, and the cause of most cases of CVID is unknown. Many people with CVID carry a DNA variation called a polymorphism in a gene known as TACI. However, while this genetic abnormality confers increased risk of developing CVID, it alone is not capable of causing CVID. CVID is also linked to IgA deficiency, a related condition in which only the level of the antibody immunoglobulin A (IgA) is low, while levels of other antibody types are usually normal or near normal. IgA deficiency typically occurs alone, but in some cases it may precede the development of CVID or occur in family members of CVID patients. ​Symptoms & Diagnosis People with CVID may experience frequent bacterial and viral infections of the upper airway, sinuses, and lungs. Acute lung infections can cause pneumonia, and long-term lung infections may cause a chronic form of bronchitis known as bronchiectasis, which is characterized by thickened airway walls colonized by bacteria.   People with CVID also may have diarrhea, problems absorbing food nutrients, reduced liver function, and impaired blood flow to the liver. Autoimmune problems that cause reduced levels of blood cells or platelets also may occur. People with CVID may develop an enlarged spleen and swollen glands or lymph nodes, as well as painful swollen joints in the knee, ankle, elbow, or wrist. In addition, people with CVID may have an increased risk of developing some cancers. Doctors can diagnose CVID by weighing factors including infection history, digestive symptoms, lab tests showing very low immunoglobulin levels, and low antibody responses to immunization. ​Treatment CVID is treated with intravenous immunoglobulin infusions or subcutaneous (under the skin) immunoglobulin injection to partially restore immunoglobulin levels. The immunoglobulin given by either method provides antibodies from the blood of healthy donors. The frequent bacterial infections experienced by people with CVID are treated with antibiotics. Other problems caused by CVID may require additional, tailored treatments. To learn more about CVID, visit the National Library of Medicine, Genetics Home Reference CVID site  (Credits to NIH) ​ If you would like to reach out to our guest: Sheila Ames BSN, RN, PHN Holistic Health Coach Business FB page:  https://www.facebook.com/JourneyIntoWellness1 ​PID (primary immunodeficiency) group:  https://www.facebook.com/groups/journeyintowellnesspid ​Instagram:  @journeyintowellnesscoaching ​My website:  journeyintowellness.net

In this episode, Athena talks about the UK government data charts that show a negative efficacy rate for the Cabobo-19 booster shots. We also cover the upcoming Reclaim the Line protest on Jan. 15th and the Defeat the Mandates protest on Jan. 23. We talk about a new side effect of COVID and the clot shot that is causing men's penis to shrink and the Biden mandates that just won and lost in the supreme court.

JACI: In Practice Deputy Editor Scott Sicherer describes the January 2022 issue, the theme of which is “Food Allergy.” Theme topics covered include food allergy diagnostics, fatal food anaphylaxis, oral immunotherapy, and patients with multiple food allergies. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Food Allergy, COVID-19, Asthma, Dermatitis, Drug Allergy, Immunodeficiency, and Urticaria. Read the issue: https://bit.ly/JAIPJan2022. Access JACI: In Practice's entire library: https://www.jaci-inpractice.org  

In this episode, we review the high-yield topic of Severe Combined Immunodeficiency Disorder (SCID) from the Immunology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

Dr. Ramchandani discusses CVID, Common Variable Immunodeficiency.  Its a rare, but not so rare disease that affects many people in the world.  Send me an email - physiatrypodcast@gmail.com.  I realize I speak too fast - to the person who emailed me - thanks for reminding me!

This episode covers immunodeficiency caused by disorders of B cells and immunoglobulins.Written notes can be found at https://zerotofinals.com/paediatrics/immunology/igdisorders/ or in the immunology section of the Zero to Finals paediatrics book.The audio in the episode was expertly edited by Harry Watchman.

This episode covers severe combined immunodeficiency syndrome (SCID).Written notes can be found at https://zerotofinals.com/paediatrics/immunology/scid/ or in the immunology section of the Zero to Finals paediatrics book.The audio in the episode was expertly edited by Harry Watchman.

Dietary Effects upon Immunity According to RK Chandra as quoted from an introduction to the Immune System, which appeared in the American Journal of Clinical Nutrition, “Nutrition is a critical determinant of immune responses and malnutrition is the most common cause of immunodeficiency worldwide.” Work with both animals and humans consistently shows that variable Immunodeficiency's can arise as a result of various forms of malnutrition. It is important to realize that there are many forms of malnutrition, not just the starving populations of Third World countries. Protein deficiency in industrialized nations such as the United States and the European countries, is often widespread and severe. Protein calorie malnutrition causes many complex nutrient deficiencies which can lead to immune suppression. For instance, Thymus dependent T cells are reduced and their capacity to generate mediators such as Gamma Interferon and Interleukin 2 is greatly decreased. Researchers studying the relationship between the Immune System and diet consistently find a direct link. The importance of diet in multiple aspects of the immune response is inescapable. Even though there have been only a few clinical trials in this area so far, the modulation of the immune response through manipulating dietary intake will surely become one of the leading modalities in the management of immune related disorders in the future. Because protein is of vital importance in the integrity of all human cells, a deficiency of protein is probably one of the greatest factors in Immunosuppression. There are several reasons why protein deficiency may exist in humans. Firstly, and most obviously, is a lack of protein in the diet. In so called civilized' countries, we assume that no one is protein deficient, but surveys of dietary habits done by many institutions, including our own, show that indeed many millions of people do not eat adequate amounts of high quality complete protein. Another factor in protein deficiency is lack of absorption. As we age, protein foods become more and more difficult to digest and assimilate at the cellular level. This is due to a reduction in the protein digestive substance called Hydrochloric Acid, naturally present in the stomach. As we age Hydrochloric Acid is diminished through the over consumption of dead and lifeless foods. For this reason, the first recommendation for building and maintaining a strong, healthy Immune System is to ensure that not only adequate protein is being consumed but that the digestion of that protein is complete. We do that by adding a multi purpose digestive enzyme product that contains Betaine Hydrochloride to each meal. What about the role of fats in the diet? Fats are among the most commonly misunderstood foods in the diet. A low fat diet is not generally healthy for people except under certain very specific circumstances. The low fat diet craze of the past twenty five years has produced a variety of health challenges as well as premature aging. Conversely, a high fat diet is not necessarily healthy either. More important than quantity, is the source of the fat in the diet. Some fats are not only less beneficial than others but, in some cases, contribute to a variety of disease processes. Polyunsaturated Fats not only produce the Free Radicals directly responsible for Atherosclerosis, but excessive, fatty acids from these oils have been established in Immunodepression. (For further information on Heart Disease refer to Special Report #4 entitled Heart Disease: The Real Cause, The Real Answer.) By reducing fats, specifically Polyunsaturated Fats, we can enhance the performance of the natural killer cell activity.