Podcast appearances and mentions of Dickson Despommier

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

The entire TWiV team comes together to pay tribute to Dickson Despommier, then reviews antibodies to H5N1 virus in veterinarians working with dairy cattle, Elisabeth Bik donates prize money for data integrity analyses, measles outbreak in Texas, and use of an alternative genetic code by human microbiome phages. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, Angela Mingarelli, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Livestream tribute to Dickson (Office Hours) Dickson's Wikipedia page Dickson's obituary (NY Times) Dickson websites: trichinella.org, thelivingriver.org, fordhamopolis.com, despommierphotoart.com Alan's tribute to Dickson (alandove.com) H5N1 seroprevalence (MMWR) Elisabeth Bik donates prize money (Science) Measles outbreak in Texas (Texas DSHS) Human microbiome phages use alternative genetic code (Nat Comm) Letters (mostly not) read on TWiV 1195 – all about Dickson Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Rare spotting of humpback anglerfish “diablo negro” (Melanocetus johnsonii) in Tenerife, Canary Islands. First time ever observed alive! Brianne – Moonwalking with Einstein inspired by reading NY Times article about Recent memory champ Kathy – Witness History 9 minute podcasts Rich – APOD: Perijove 11: Passing Jupiter Alan –  Ecological succession on abandoned farmland Jolene –  Parasitic Diseases Lectures and first 27 episodes of This Week in Parasitism Vincent – The New City Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In this special tribute episode of The Vertical Farming Podcast, I honor the life and legacy of Dr. Dickson Despommier, the visionary who laid the foundation for vertical farming as we know it today.His book, The Vertical Farm: Feeding the World in the 21st Century, completely changed the way I thought about food production, sustainability, and the future of agricultureReading it in 2019 was a turning point for me—it was the spark that led to the creation of this podcast.Over the years, I've spoken with over 150 CEOs and founders in the industry, and so many of them cite Dr. Despommier as a major influence on their work. His vision of growing food in urban skyscrapers was once considered radical, but today, it's shaping the future of sustainable agriculture.Though he's no longer with us, his ideas continue to inspire, and it's up to all of us—researchers, farmers, entrepreneurs, and investors—to carry his vision forward. This episode is my way of saying thank you to a man whose ideas changed my life—and the world.Additional Social TributesMarc Oshima on LinkedInNona Yehia on LinkedInHonoring Dr. Dickson Despommier: The Visionary Who Planted the Seeds for Vertical Farming's Future - Henry Gordon-SmithThanks to Our SponsorsBio520 Resources MentionedThe Vertical Farm: Feeding the World in the 21st Century, by Dickson Despommier - https://amzn.to/3QhWWyYConnect With UsVFP LinkedIn - https://www.linkedin.com/company/verticalfarmingpodcastVFP Twitter - https://twitter.com/VerticalFarmPodVFP Instagram - https://www.instagram.com/direct/inbox/VFP Facebook - https://www.facebook.com/VerticalFarmPodSubscribe to our newsletters!AgTech Digest - https://agtechdigest.comThe Indoor Farmer - https://www.indoorverticalfarm.com/Horti-Gen Insights - https://www.hortigeninsights.com/

TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV Fundraiser Novel H5N1 in Cambodia (medRxiv) More cVDVP2 circulation (polioeradication.org) Infectious parvovirus B19 with proteases (Nat Comm) B cell receptor enhancement of dengue disease (PLoS Path) Timestamps by Jolene. Thanks! Weekly Picks Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool's gold. Primary article Pyrite video Vincent – ‘We need to be ready for a new world': scientists globally react to Trump election win Listener Picks Jack – Coronavirus vaccine update Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiP taps into Dickson's knowledge of Trichinella to discuss an outbreak in humans who consumed rare bear meat, and the impact of globalization and climate change on the epidemiology of the species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Outbreak of human trichinellosis (CCDR) Impact of climate change on Trichinella (Food Waterborne Parasit) Letters read on TWiP 246 Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Lilach Sheiner joins TWiP to talk about her career and her work on engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Hosts: Vincent Racaniello, Dickson Despommier, and Christina Naula Guest: Lilach Sheiner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Engineering T. gondii for protein secretion (Nat Micro) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Polio vaccination in Gaza (Reuters) Zoonotic viruses in farmed fur animals (Nature) HPV vaccination and cancer rates (JAMA Net Open) 40 kb RNA genome without error correction (PNAS) Stopping the phage tape measure protein (Nat Commun) Tail assembly interference (Nat Commun) Letters read on TWiV 1151 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiP solves the case of the Woman with White Worms, and submits a new case involving a 1 year old in northeastern Panama with a fatal leg infection. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Enterobius, the pinworm (TWiP 19) Hero: Mary Pritchard New Case This case comes from Panama mid summer 2024. A provider for Floating Doctors working in the coastal region in northeastern Panama. This case involves a one year old, so the history is a bit difficult, but there may have initially been a scratch or some sort of break in the skin. Otherwise healthy but over a period of time this area expands and becomes a deep necrotic wound on the leg. Several other nearby wounds develop and become deep and infected. By the time this one year old is seen by the provider much of the leg appears eaten away. This is just the tip of the iceberg as a number of others develop similar wounds in the area. No prior medical history. Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox outbreak is PHEIC (WHO) Tecovirimat not great against monkeypox virus clade I (NIH) Case of Mpox Clade I in Sweden (PHAS) Mpox and pets in USA (Emerg Inf Dis) SARS-CoV-2 widespread in wildlife communities (Nat Comm) Salivary GAPDH benefits plant virus transmission (Nat Comm) Letters read on TWiV 1143 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA Confirms Evidence That Liquid Water Flows on Today's Mars Kathy – TBP for PCR internal control Rich –  xmACIS2 compares the data in the ACIS database to that in GHCN-Daily Alan – Larry, the world's most highly cited cat Vincent – The Viral Paleontologist Who Unearths Pathogens' Deep Histories Listener Pick Ryan – Mpox emergencies AP News one and two Rona – Up in smoke David – Ode to Joy (YouTube, TikTok) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox widespread in Africa (CIDRAP) Africa declares Mpox emergency (Science) COVID drops to 10th leading cause of US deaths (MMWR) Response to detection of poliovirus in Gaza (WHO) Molecular mimicry in MIS-C (Nature) Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm) Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr) Letters read on TWiV 1141 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha'Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women's basketball team Rich – Texas State University Forensic Anthropology Research Facility Vincent – Sea lion ‘camera crews' capture new footage of ocean floor Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello, Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Daily natural history of Plasmodium infections (Lancet Microbe) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server What's going on with measles? (J Virol) Poliovirus in Gaza (Science) Sanitation concerns in Gaza (AP) Community vaccine beliefs (PLoS One) 14 year old dies of Nipah in India (Hindustan Times) Selection of nirmatrelvir resistance mutants (Sci Adv) CCHFV monoclonal antibodies (Cell Rep) CCHFV vaccine (TWiV 565) Prometheus Project (TWiV 578) TWiV at USAMRIID (TWiV 1015) Letters read on TWiV 1135 Timestamps by Jolene. Thanks! Weekly Picks Angela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth's core has slowed so much it's moving backward Alan – Article about the Smithsonian's forensic ornithology lab, led by Carla Dove Vincent – Seventh patient ‘cured' of HIV: why scientists are excited Listener Pick Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Measles in Brooklyn NY (ABC) Measles in Washington DC (DC Health) Global childhood immunization stalls (WHO) Licensed H5N1 vaccines protect against circulating strains (Nat Med) Viruses moving without passports (European CDC) OC42-SARS-CoV-2 replacement spike virus (PNAS) Deep mutational scanning of Lassa virus glycoprotein (Immunity) Letters read on TWiV 1133 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Articles on Chevron decision (one, two, three) Measles in New Hampshire and Vermont (NH DHHS) Pathogenicity and transmission of bovine H5N1 virus (Nature) Letters read on TWiV 1131 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Stockholm Wood City Rich – “The Wide Wide Sea” by Hampton Sides Vincent – Tour de France stage 12 Listener Picks Amy – Earth Forced from the Protective Heliosphere: What Do We know? Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Michael Barrett joins TWiP to discuss progress in the elimination of human African trypanosomiasis caused by Trypanosoma brucei gambiense. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Michael Barrett Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Elimination of human African trypanosomiasis (PLoS NTD) Hero: David Livingstone Become a patron of TWiP  Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor's subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Pentagan anti-vac campaign to undermine China (Reuters) NY governor subway mask ban (AP News) Colorado bat facility sparks outbreak fears (Science) House NIH budget bans gain of function research (Science) Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) Letters read on TWiV 1127 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking Listener Picks Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Marilyn Fabbri joins TWiP to reveal the case of a patient who became very ill after he and a number of friends attended a large dinner where venison and boar were served. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Marilyn Fabbri Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Toxoplasma gondii (TWiP 12) Parasitic Diseases Lectures #15: Toxoplasmosis Letters read on TWiP 237 Become a patron of TWiP  New Case Man in his 60s with HIV/AIDS CD4 count less than 50, CD4% less than 5% and elevated viral load (VL) with report of prior CNS toxoplasmosis requiring a craniotomy, disseminated Mycobacterium avium complex (MAC), comes in with fever and very watery diarrhea x 4 days. He reports that he lives in Georgia but comes up to NY for his HIV care and stays in NYC. Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Grants Register for ASV Annual Meeting H5N1 influenza virus in raw cow milk infects mice (NIAID News) Dynamics of measles virus immunity from birth (Nat Comm) Mechanism of cis-preferential HBV reverse transcription (Cell) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Oldest virus in Neanderthal bones Brianne – Jeopardy! winner reveals entwined memory systems make a trivia champion Kathy – Bright future of intelligent fabrics primary article and Self-dyeing textiles (primary article) Rich – Farewell to HD Atlas; Boston Dynamics Retires HD Atlas Robot Alan – Why vaccinating cattle against H5N1 is hard Vincent – Singapore Airlines turbulence: why climate change is making flights rougher Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiP solves the case of a man in his 50s reporting months of abdominal discomfort, who takes mebendazole and some time afterwards vomits a worm into the sink. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute The giant intestinal worm, Ascaris lumbricoides (TWiP 21) Parasitic Diseases Lectures #24: Giant Intestinal Worm (YouTube) Letters read on TWiP 235 Hero: Ernst A. H. Friedheim Become a patron of TWiP  New Case: I first learned about this case from a colleague at work who tells me that their friend has just gotten really sick. The friend is described as having had multiple illnesses over time but that he has never been as sick as he recently got. He reports that the illness began as a diffuse myalgia with fever, there was some sore throat, noted swelling in the neck, and overwhelming fatigue. He tells some of his friends that he is feeling really terrible and it turns out that some of his friends also feel poorly. It turns out that about a week prior to the onset of his symptoms he and a number of friends attended a large dinner where venison and boar was served.  This individual is then seen in our office. Some testing is done. He feels really terrible and despite being reassured that he should get better without treatment he is given therapy. Send your guesses to twip@microbe.tv with TWiP 235 in the subject line Send your questions and comments to twip@microbe.tv

TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Chinese virologist sleeps on street (Nature) Measles in Haifa (Jerusalem Post) Waterborne illness spreads in Gaza (Reuters) Interstate spread of H5N1 virus in dairy cattle (bioRxiv) Orangutan uses medicinal plants (Science) Parechovirus cell receptor identified (Nat Comm) Necroptosis blockade prevents lung injury in influenza (Nature) Necroptosis, pyroptosis and apoptosis (Cell Mol Immunol) Letters read on TWiV 1111 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA's Webb Finds Ethanol, Other Icy Ingredients for Worlds Alan – MyClimate.org calculators Vincent – Twenty-Five Lectures in Virology 2024 Listener Picks Alan – NPR story and interactive quiz on pandemic respiratory disease transmission Az – H5N1 Avian Flu in Mammals Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Bird flu in humans (NY Times) H5N1 genome sequences (USDA) Measles cases and outbreaks (CDC) Latest measles statistics (UK) Positive selection underlies ORF8 loss (Nat Comm) Spillover potential of bat H9N2 influenza virus (Nat Comm) Letters read on TWiV 1109 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Journey to the Andromeda Galaxy, Highest jump in human history Alan – What Does a Scientist Look Like? photo gallery by Nature, and public display in London Vincent – The Campus-Left Occupation That Broke Higher Education, I'm a Columbia Professor. The Protests on my Campus are not Justice Listener Picks David – Blue Angels unbelievable footage Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course). Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Letters read on TWiV 1107 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin' Vincent – A quote from Georgia O'Keefe: “I think it's so foolish for people to want to be happy. Happy is so momentary – you're happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher Listener Picks Julia – Recent success in troubleshooting autoclave challenges Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiP solves the case of the physician with no significant previous medical history who is currently doing their fellowship training develops diarrhea, and presents a new clinical case for our astute listeners to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Keith Vickerman Letters read on TWiP 233 Become a patron of TWiP New Case study: I was recently asked about this case while I was off visiting Denmark. A man in his 50s has been reporting months of abdominal discomfort and decides to go discuss this situation with a local pharmacist. He describes this discomfort, some nausea, and some bloating of the abdomen. The pharmacist recommends that he take mebendazole. He takes the mebendazole and some time afterwards he vomits a worm into the sink. The worm does not have any obvious segmentation and appears completely nonsegmented and is moving around. One end is very pointy and the other little less so.   Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) Navigating the U.S. Immigration System webinar International Conferene on Pandemic Preparedness Avian influenza in dairy cows North Carolina and South Dakota H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC Polio from Afghanistan to Pakistan extending public health emergency CHAT GPT to combat vaccine hesitancy Viral hepatitis worldwide Dengue public health alert in Puerto Rico Cherry trees being drowned by water level rise in DC Paul in iron lung dies (NPR) Hepatitis B virus in Eastern Eurasia (Nat Comm) Antibody-independent protection against heterologous SARS-CoV-2 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Do Other Planets Have Solar Eclipses? Kathy – Radcliffe Wave and Mt. Etna smoke rings with video Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation Alan – Rogue attempt to clone giant sheep for captive hunting Vincent – The Scientists Rock. Literally. Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiP solves the case of the Woman With White Worms, and presents a new clinical case to decipher. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Ann Bishop Become a patron of TWiP New Case study: A physician with no significant PMH who is currently doing their fellowship training develops diarrhea. The diarrhea is significant enough that they are beginning to feel weak, lightheaded, and end up going to the local ER. The physician lives in NYC, works most of the time but did just get back from a week-long vacation in Florida with their long-term partner where they got a chance to swim in the pool and get some sun. They returned feeling well and then noted the onset of the diarrhea. The diarrhea was watery, with some abdominal cramping but no noted blood or actual fever. The stool did not have a strong smell and no floating stools were reported. The physician was given IVF and returned home feeling better but now gets a call that there is a parasite on the stool testing and is recommended to take a medicine they have never heard of 3x per day for 3 days.  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Paul Offit joins TWiV to discuss his latest book, “Tell Me When It's Over”, an insider's guide to deciphering COVID myths and navigating our post-pandemic world. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Tell Me When It's Over by Paul Offit Navigating the U.S. Immigration System (webinar) Classifying Viral Subspecies (Workshop) Options XII for the Control of Influenza (Meeting) Letters read on TWiV 1101 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way's Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: Vincent Racaniello Guests: Sheree Yau and Victoria Queiroz Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier 8:16 Virophage control of antarctic algal host-virus dynamics (PNAS) Timestamps by Jolene. Thanks! Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) Two groups of pithoviruses (J Virol) Educational toolkit for virology classes (J Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) Continued circulation of oropouche virus (PAHO and WHO) Herpesviruses in fur seals and sea lions (PLoS One) Sex-specific effects of SARS-CoV-2 infection (PLoS One) Drivers of 2022 Mpox virus epidemic (Cell) How AAV gene transfer works (YouTube) Humanized mouse model for AAV gene therapy (Nat Comm) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd Listener Pick Anne – Why Reed Jobs is betting on cancer innovations Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Maria Adelaida Gomez joins TWiP to discuss her career and the work of her laboratory on understanding the healing process during cutaneous leishmaniasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Maria Adelaida Gomez Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CIDEIM Healing in cutaneous leishmaniasis (J Immunol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Fatal case of Alaskapox (AK Beacon) MERS in Kenya (Emerg Inf Dis) Diagnostic tests for Nipah and Lassa (CEPI) Measles in Arizona and Minnesota HCV-derived circular RNAs (PNAS) Resident memory CD8 T cells prevent respiratory virus transmission (Nature) Letters read on TWiV 1087 1:24:33 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Visualizing Science: Illustration and Beyond Brianne – Vaccination from the Misinformation Virus and Invisible Corps Alan – Preventing needlephobia in kids Vincent – Two new Djs I discovered Rosana Nun and Sunset Cartel Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open) Onradivir new influenza antiviral (Lancet) Oropouche fever in Brazil (PAHO) Maryland and Ohio measles Repealing school vaccination exemptions (JAMA New Open) Increases risk of FMDV entry into Europe (pig333) Severe primary and secondary dengue (Nat Med) Mitigation of measles immune amnesia and exacerbated disease (Nat Comm) Letters read on TWiV 1087 Timestamps by Jolene. Thanks! Weekly Picks Dickson – For Your Processing Pleasure: The Sharpest Pictures of Jupiter's Volcanic Moon Io in a Generation Angela – Whale Scientists Rich – Benefit-risk assessment of vaccines; The Brighton collaboration standardized module for vaccine benefit-risk assessment; Vaccine adverse events: causal or coincidental?; Austin area Singing Valentines Vincent – International Day of Women and Girls in Science, 11 February Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiP discusses a tapeworm that causes extreme lifespan extension in infected ant workers, and a candidate antibody drug for prevention of malaria. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Extreme lifespan extension in tapeworm-infected ant workers (Roy Soc Open Sci) Candidate antibody drug for prevention of malaria Ceilidh goes viral (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Viruses of Microbes 2024 Pig virus imperils food security in Borneo (Science) Measles outbreaks in UK and Europe (Nature) Fatal Nipah virus infections in Bangladesh (CIDRAP) Yellow fever outbreak in Sudan (Crisis24) COVID-19 influenced by type of immunodeficiency (Sci Transl Med) Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe) Letters read on TWiV 1085 Timestamps by Jolene. Thanks! Weekly Picks Dickson – JWST details of 19 spiral galactic centers Rich – Great White Shark Attack And Breach Vincent – Black History Month and Lost Photographs of Black America Listener Picks Louise – The Mystery Of The Village That Beat The Black Death Pierre – Three things airlines don't want you to know Brandon – Professor Dave explains Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Jay Nelson obituary Measles outbreak in Europe and Central Asia (UNICEF) Closing the toilet lid doesn't reduce virus aerosols (Am J Inf Control) NASA's ingenuity helicopter mission ends (NASA) HPV vaccine prevents invasive cervical cancer (J NCI) Designing AAV vectors with machine learning (Sci Adv) Letters read on TWiV 1083 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Asian girl building a life building a fence to protect a bamboo house Rich – Gator Country: Deception, Danger, and Alligators in the Everglades by Rebecca Renner Alan – Strange Bedfellows, by Ina Park Vincent – Star and Sphere kit – try the main page too Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Midwife gave children pellets instead of vaccines (NY Times) Vaccine derived poliovirus circulation in Indonesia (WHO) 9th case of measles in Philadelphia (City of Philadelphia) Measles exposure warning northern Virginia (Virginia DOH) China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ) Wisconsin bill to restrict gain of function experiments (Science) Virus infection of insects causes long wings (PNAS) Reverse zoonoses of influenza H1N1 virus in swine (PLoS Path) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Concerto for Horn and Hardart, P. Schickele Angela – ChatGPT4 Brianne – How mRNA Vaccine Works, Why We Need Two Doses of mRNA Vaccine Rich – Evolutionary basis for the human diet: consequences for human health by P. Andrews, R.J. Johnson Vincent – Virology Lectures 2024 Listener Picks Geoff and Anonymous – Dickson Despommier wants our cities to be like forests Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Jim Small joins TWiP to solve the case of the 41 year old Man with sudden GI distress and itchy hives, followed by a discussion of parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Jim Small Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Parasites and childhood stunting (Trends Parasitol) Letters read on TWiP 227 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

THE RISE OF VERTICAL FARMING FROM THE FEBRUARY 2023 ISSUE OF INSIDE GROWER MAGAZINE WRITTEN BY DANIEL PILSWORTH NARRATED BY BILL CALKINS   EXCERPT: The sky is the limit: In 1999, Columbia professor Dickson Despommier used the term “vertical farming” to describe a system of agriculture in which crops are grown indoors on vertically stacked platforms. His students imagined skyscrapers with lush greens, bursting from the sides of city buildings and providing hyper-local produce to dense urban centers. In the two decades since then, vertical farming has grown up in unexpected—yet promising—ways. In fact, according to the most recent P&S Intelligence report, the total vertical farming market size in 2021 was $3.98 billion and this number is expected to grow 25.2% annually to reach $30.2 billion by 2030.   Read the digital edition of Inside Grower Magazine—February 2023: https://www.ballpublishing.com/magazine/ig_23_02/index.aspx

TWiP reviews some parasite stories of 2023, including progress in the control of malaria and polio, and review a connection between parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Second malaria vaccine (Nature) Malaria report 2023 (WHO) Malaria and climate change (WHO) Parasites and childhood stunting (Trends Parasitol) Sea creature spotted off Japan identified (Science) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek's disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Ancient chickens and Marek's disease virus (Science) Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) Letters read on TWiV 1074 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – Earthquakes of the 20th Century Vincent – Animator Chris Georgenes especially Tricycle animation study Listener Picks Jason – Spot-on, quick booster explainer and “Inverse” vaccine Slashdot's summary. the full article, primary research article Meika – Iceland earthquake site Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus. Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Brett Lindenbach passes (Yale Medicine) Virome of small mammals (Cell) Epstein-Barr virus nanoparticle vaccine (Cell Host Micr) Letters read on TWiV 1073 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music Kathy – Two APODS  Winter solstice, 183 Days in the Sun and the Same color illusion Vincent – The American Academy of Microbiology discusses gain-of-function research of concern (GOFROC) and enhanced potential pandemic pathogens (ePPP) Listener Picks Gregory – Climate Change – A revised prediction – Steven Chu John – Detergent packs are kinda wishy-washy (Technology Connections) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Lee Gottesdiener joins TWiP to help solve the case of the 46 Year Old Man with Ongoing Upper Extremity Swelling, and review plant‑based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Vaccine against cow parasite (Vert Farm Daily) Protective vaccine against bovine parasitic nematode Ostertagia ostertagi Hero: Dr. Katy Ewer Letters read on TWiP 225 Become a patron of TWiP Case Study for TWiP 225 41-year-old male mechanical engineer, former Army Ranger trainee, moved from Denver, CO to Chattanooga, TN. He was in his usual state of vigorous health, hiking, doing Spartan races, working on his semi-rural property,  and commuting to his place of work daily when about three months previous to his diagnosis, he began having episodes of sudden GI distress with diarrhea, followed by itchy hives in axilla and groin. He treated these episodes with Benadryl and got relief. At 10 PM one evening, he had another such episode, again took Benadryl, but began to experience gradual onset but relentlessly increasing shortness of breath and wheezing. He was taken at high speed to the Emergency Room by his wife. He reported that relaxation with a repetitive, meditative prayer seemed to control the symptoms but said it was like his throat was closing. Past history includes variable exercise and cold-induced asthma treated with an inhaler as a child, with only rare episodes in adulthood related to high exposure to allergens like cat dander. Family history is not contributory. Diet was omnivorous. They had one dog, a labradoodle named Raphael, which they chose because he was “hypoallergenic.” In the Emergency Department, he was treated with bronchodilators, intramuscular epinephrine, and antihistamines, and the symptoms abated. The experienced ED physician ordered a diagnostic test, having seen other similar cases in the region. A lifestyle intervention was successful.

Chuck Knirsch returns to TWiP to discuss the Neglected Tropical Diseases Roadmap published by WHO, which sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups. Chuck Knirsch returns to TWiP to discuss the Neglected Tropical Diseases Roadmap published by WHO, which sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups. Hosts: Vincent Racaniello, Dickson Despommier, and Chuck Knirsch Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Neglected Tropical Diseases Roadmap (WHO) World malaria report 2023 (WHO) Become a patron of TWiP Send your questions and comments to twip@microbe.tv

On this all-bacteriophage episode, TWiV explains the ‘vampire phage', and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Gerd Sutter passes (LMU) Avian influenza A (H5N1) Cambodia (WHO) CWD expands in Montana (CIDRAP) National Wastewater Surveillance System (CDC) Vampire phage paper (ISME J) UMBC phage hunters (UBMC) Vampire viruses prey on other viruses (Conversation) Phage internalized by mammalian cells (PLoS Biol) Phage uptake by mammalian cells (iScience) Phage-mammalian cell interactions (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Biden skips climate summit (NY Times) Rich – Lilium electric VTOL jet Alan – The Far Land, by Brandon Presser Jolene – Bacteriophage T4 infection watercolor painting by David Goodsell Vincent – Using narratives and storytelling to communicate science with nonexpert audiences Listener Picks Darach – It depends t-shirt Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiP solves the case of the Haitian female with AIDS and voluminous diarrhea, and review the pathogenesis, epidemiology, prevention and treatment of malaria and Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #223 (63 MB .mp3, 88 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Malaria (Lancet) Chagas disease (AJTMH) Hero: Joe Cook Letters read on TWiP 223 Become a patron of TWiP Case Study for TWiP 223 46 yo man with minimal pmh, elevated cholesterol, ongoing right upper extremity swelling, 5-10 years intermittently. Goose egg swelling on hand, foot. Lasts for hours, every few months. Go to ER, right upper extremity. Lives in NYS suburbs, Is vet and epidemiologist. Has done extensive travel, Liberia, Ghana, DRC, Uganda, Rwanda, 2 week duration. Doing work, fair amount of animal contact with bats, rodents, birds. PE unremarkable except for swelling of right arm. Blood work unremarkable. 2.5 yr later notice prickling irritation under right eyelid, think they see undulation under skin.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier House approves ban on gain-of-function research (Science) Virology under the microscope (J Virol) CWD detected in another Tennessee county (CIDRAP) Polio eradication: Do no harm (Science) nOPV2 causes polio (MMWR) How is nOPV2 doing? (Polioeradication.org) Feline infectious peritonitis caused by recombinant coronavirus (bioRxiv) New feline coronavirus kills thousands of cats (Science) Feline coronavirus with Gary Whittaker (TWiV 963) Letters read on TWiV 1065 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Climate Action and How to find joy in climate action Brianne – A Virus that Generates Electricity Kathy – Intolerable Genius: Berkeley's most controversial Nobel laureate Rich – Programmed DNA Elimination (PDE): Quanta; Current Biology Alan – KBDfans mechanical keyboard kits Vincent – The Covid Vaccine Windfall Turns for Pfizer and Moderna Listener Picks Meika – Iceland Eruption or not? Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Seasonality of endemic COVID-19 (mBio) Diversity of non-vaccine targeted HPVs (Cell Host Microbe) Wart's up doc? (TWiV 126) Letters read on TWiV 1061 Timestamps by Jolene. Thanks! Weekly Picks Dickson – 2023 expected to be hottest year on record after warmest October ever Kathy – You can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably) Alan – Landmark case to get sanitation declared a civil right Vincent – SciComm Studios Listener Picks Charmaine – Petition fo National Science Appreciation Day Peter – Let's eradicate polio this winter Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Monoclonal antibody neutralizes all three poliovirus serotypes (Nat Comm) Blocking Ebolavirus intercellular spread (Cell Rep) Letters read on TWiV 1059 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Climate Science Angela – Spider Ballooning (Wikipedia) Kathy – Richard Harris Art Collection Rich – “The Murderbot Diaries” by Martha Wells Alan – Old Gods of Appalachia Vincent – Poetry Foundation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

At the meeting of the American Society for Tropical Medicine and Hygeine in Chicago, Natasha joins TWiP to solve the case of the Man with a Generalized Seizure and Infectious Forms in the Brain. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Natasha Spottiswoode Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Treatment of Balamuthia encephalitis with nitroxoline (Emerg Inf Dis) Letters read on TWiP 222 Become a patron of TWiP Case Study for TWiP 222 Haitian creole speaking, cachetic female in her 50s w/ hx HIV (noncompliant on medication), migrating from Haiti brought in by her daughter for dysphagia, cough x days, associated with NBNB vomiting, oral thrush extending to soft palate, concerning for oropharyngeal candidiasis. Weeks of nonresolving diarrhea. Admitted for failure to thrive and deconditioning, found to be Parainfluenza 3 positive), undergoing TB rule out. Diarrhea is voluminous, pt is dehydrated, there has been significant weight loss and lethargy over the last few weeks. MHx: HIV  Shx: Lives in haiti Remarried, Last sexual encounter 2 years ago. Denies illicit drug use. Drinks alcohol  Allergies: No Active Allergies Labs return with CD4 count in the 50s, elevated viral load. CD4 55/3% Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Michelle and Alexander join TWiP to solve their case of the 36 Year Old Male with shortness of breath, stinging pain in the extremities, fatigue, abdominal cramps, and bowel irregularities, and discuss host cell invasion by Trypanosoma cruzi. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guests: Michelle Naegeli and Alexander Grieb Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode cAMP-dependent invasion by Trypanosoma cruzi (PLoS NTDS) Letters read on TWiP 220 Become a patron of TWiP Case Study for TWiP 221 This is the case of a  man in his 50s, with no remarkable prior medical history, who received care at a hospital in northern California, USA, after experiencing a generalized seizure. Magnetic resonance imaging (MRI) demonstrated a solitary left temporal lobe T2 hyperintensity with gadolinium rim enhancement and surrounding edema. After receiving treatment with dexamethasone and levetiracetam, he was transferred to an academic medical center. Examination by neurology consultants noted disorientation, inattention, moderate aphasia (difficulty communicating), and mild right hemiparesis. Cerebrospinal fluid (CSF) testing revealed increased nucleated cells up to 80/UL (60% lymphocytes, 17% neutrophils, 23% monocytes), protein concentration 38 mg/dL, and glucose concentration 100 mg/dL.  They proceed to do a brain biopsy from the left temporal lobe lesion with cultures from the brain biopsy sample that did not grow bacteria, fungi, or mycobacteria. They performed metagenomic next-generation sequencing (mNGS) on a CSF sample and sent brain biopsy samples for universal broad-range PCR amplicon sequencing (uPCR) for bacteria, fungi, Mycobacterium tuberculosis, and nontuberculous mycobacteria. which is preliminarily reported as showing well-formed granulomata with acute inflammation. Rereview of neuropathology raised concern for certain round infectious forms that are about 50um in size with some surrounding clearing and a dark area within these forms. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP solves the case of the Hiker from Queens who Denies Bug Bites, and reveal two different malaria experimental vaccines that target different parts of the parasite life cycle. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Malaria transmission-blocking vaccine (Lancet Inf Dis) mRNA vaccine against malaria (Nat Immunol) Letters read on TWiP 220 Become a patron of TWiP Case Study for TWiP 220 Sent by Michelle and Alexander from the First Vienna Parasitology Passion Club A 36 year old male presents to the local ED with shortness of breath. Additional symptoms included a stinging pain in different parts of his extremities, fatigue, abdominal cramps and bowel irregularities. On exam he was resting comfortably and his vitals were normal, but the patient appears very distressed by his symptoms. His left eye showed signs of irritation, including redness and swelling. A detailed history reveals travel to the Caribbean about 4 years ago and several short trips to central and east Africa, all between 5 and 10 years ago. His initial labs were grossly unremarkable and a chest x-ray showed no abnormalities. The patient himself suspected a specific parasitic etiology of his symptoms, so we performed a number of serologies and stool examinations in search of  parasitic diseases. None of the tests revealed evidence of an ongoing infection.  He is HIV negative and not sexually active at the moment. He has no pets and no other recent travel history. He eats a normal diet and has been out of work for two years. Thank you for the opportunity to participate in this fantastic project! All the best,  Michelle and Alexander from the First Vienna Parasitology Passion Club Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees