Podcasts about DNA replication

Biological process

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DNA replication

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Best podcasts about DNA replication

Latest podcast episodes about DNA replication

The Medbullets Step 1 Podcast
Biochemistry | DNA Replication

The Medbullets Step 1 Podcast

Play Episode Listen Later Apr 3, 2025 11:10


In this episode, we review the high-yield topic of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠ DNA Replication ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Biochemistry section.Follow⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets

Johnny McKenzie's Podcast
Episode 10: DNA Replication JE 17

Johnny McKenzie's Podcast

Play Episode Listen Later Oct 8, 2024 2:36


Let's learn about DNA Replication and the Cell Cycle. 

Epigenetics Podcast
DNA Replication, Transcription and R-loops (Stephan Hamperl)

Epigenetics Podcast

Play Episode Listen Later Jun 13, 2024 34:27


In this episode of the Epigenetics Podcast, we talked with Dr. Stephan Hamperl from the Helmholtz Zentrum Munich about his work on how conflicts between transcription, replication, and R-loop formation influence genome stability in human cells. During the early stages of his career Stephan studied conflicts between transcription and replication in human cells, particularly focusing on R-loop structures. In our discussion, he explains the formation of R-loops and their impact on genome stability, emphasizing the importance of the orientation of replication forks approaching R-loops in determining DNA damage outcomes. Stephan then delves into his work on the MATAC-Seq method, which analyzes chromatin domains at DNA replication origins to understand replication timing variability. The method involves methylating DNA linkers between nucleosomes and using nanopore sequencing for single-molecule readouts, revealing heterogeneity in chromatin structure at replication origins. Finally, Stephan discusses his automated image analysis pipeline for quantifying transcription and replication activity overlap in mammalian genomes, addressing the challenge of visualizing these processes simultaneously. The conversation concludes with insights into Stefan's future research directions, focusing on understanding transcription-replication conflicts' molecular basis and their potential implications in cancer cell transformation. References Hamperl, S., Brown, C. R., Garea, A. V., Perez-Fernandez, J., Bruckmann, A., Huber, K., Wittner, M., Babl, V., Stoeckl, U., Deutzmann, R., Boeger, H., Tschochner, H., Milkereit, P., & Griesenbeck, J. (2014). Compositional and structural analysis of selected chromosomal domains from Saccharomyces cerevisiae. Nucleic acids research, 42(1), e2. https://doi.org/10.1093/nar/gkt891 Hamperl, S., Bocek, M. J., Saldivar, J. C., Swigut, T., & Cimprich, K. A. (2017). Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses. Cell, 170(4), 774–786.e19. https://doi.org/10.1016/j.cell.2017.07.043 Chanou, A., Weiβ, M., Holler, K., Sajid, A., Straub, T., Krietsch, J., Sanchi, A., Ummethum, H., Lee, C. S. K., Kruse, E., Trauner, M., Werner, M., Lalonde, M., Lopes, M., Scialdone, A., & Hamperl, S. (2023). Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency. Nucleic acids research, 51(22), 12303–12324. https://doi.org/10.1093/nar/gkad1022   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

PaperPlayer biorxiv cell biology
A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jul 18, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.18.549463v1?rss=1 Authors: de Jaime Soguero, A., Hattemer, J., Haas, A., Bufe, A., Di Marco, B., Bohly, N., Landry, J. J. M., Schoell, B., Rosa, V. S., Villacorta, L., Baskan, Y., Androulaki, S., Trapp, M., Benes, V., Das, B., Shahbazi, M., Jauch, A., Engel, U., Patrizi, A., Sotillo, R., Bageritz, J., Alfonso, J., Bastians, H., Acebron, S. P. Abstract: The development and homeostasis of organisms rely on the correct replication, maintenance and segregation of their genetic blueprints. How these intracellular processes are monitored across generations of different human cellular lineages, and why the spatio-temporal distribution of mosaicism varies during development remain unknown. Here, we identify several lineage specification signals that regulate chromosome segregation fidelity in both human and mouse pluripotent stem cells. Through epistatic analyses, we find that that WNT, BMP and FGF form a signalling rheostat upstream of ATM that monitors replication fork velocity, origin firing and DNA damage during S-phase in pluripotency, which in turn controls spindle polymerisation dynamics and faithful chromosome segregation in the following mitosis. Cell signalling control of chromosome segregation fidelity declines together with ATM activity after pluripotency exit and specification into the three human germ layers, or further differentiation into meso- and endoderm lineages, but re-emerges during neuronal lineage specification. In particular, we reveal that a tug-of-war between FGF and WNT signalling in neural progenitor cells results in DNA damage and chromosome missegregation during cortical neurogenesis, which could provide a rationale for the high levels of mosaicism in the human brain. Our results highlight a moonlighting role of morphogens, patterning signals and growth factors in genome maintenance during pluripotency and lineage specification, which could have important implications for our understanding on how mutations and aneuploidy arise during human development and disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv cell biology
CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stress

PaperPlayer biorxiv cell biology

Play Episode Listen Later Apr 22, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.21.537900v1?rss=1 Authors: Wen, B., Zheng, H.-X., Deng, D.-X., Zhang, Z.-D., Heng, J.-H., Liao, L.-D., Xu, L.-Y., Li, E.-M. Abstract: The translesion DNA synthesis (TLS) pathway mediated by proliferating cell nuclear antigen (PCNA) monoubiquitination is an essential mechanism by which cancer cells bypass DNA damage caused by DNA replication stress to maintain genomic stability and cell survival. Chromatin assembly factor 1 subunit A (CHAF1A) traditionally promotes histone assembly during DNA replication. Here, we revealed that CHAF1A is a novel regulator of the TLS pathway. High expression of CHAF1A is significantly associated with poor prognosis in cancer patients. CHAF1A promotes fork restart under DNA replication stress and maintains genome integrity. CHAF1A enhances the interaction between PCNA and E3 ubiquitin protein ligase RAD18 and promotes PCNA monoubiquitination, thereby promoting the recruitment of Y-family DNA polymerase Pol {eta} and enhancing cancer cell resistance to stimuli that trigger replication fork blockade. Mechanistically, CHAF1A-mediated PCNA monoubiquitination is independent of CHAF1A-PCNA interaction. CHAF1A interacts with both RAD18 and replication protein A2 (RPA2), mediating RAD18 binding on chromatin in response to DNA replication stress. Taken together, these findings improve our understanding of the mechanisms that regulate the TLS pathway and provide insights into the relationship between CHAF1A and the malignant progression of cancers. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv cell biology
Ki-67 is necessary during DNA replication for forks protection and genome stability

PaperPlayer biorxiv cell biology

Play Episode Listen Later Apr 19, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.18.537310v1?rss=1 Authors: Stamatiou, K., Huguet, F., Spanos, C., Rappsilber, J., Vagnarelli, P. Abstract: Background: The proliferation antigen Ki-67 has been widely used in clinical settings for cancer staging for many years but investigations on its biological functions have lagged. Recently, Ki-67 was shown to regulate both the composition of the chromosome periphery and chromosome behaviour in mitosis as well as to play a role in heterochromatin organisation and gene transcription. However, a role for Ki-67 in regulating cell cycle progression has never been reported. The progress towards understanding Ki-67 function have been limited by the tools available to deplete the protein coupled to its abundance and fluctuation during the cell cycle. Results: Here we have used an auxin-inducible degron tag (AID) to achieve a rapid and homogeneous degradation of Ki-67 in HCT116 cells. This system, coupled with APEX2 proteomics and phospho-proteomics approaches, allowed us to show for the first time that Ki-67 plays a role during DNA replication. In its absence, DNA replication is severely delayed, the replication machinery is unloaded, causing DNA damage that is not sensed by the canonical pathways and dependant on HUWE1 ligase. This leads to replication and sister chromatids cohesion defects, but it also triggers an interferon response mediated by the cGAS/STING pathway in all the cell lines tested. Conclusions: We have unveiled a new function of Ki-67 in DNA replication and genome maintenance that is independent of its previously known role in mitosis and gene regulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Intelligent Design the Future
David Galloway: The Fetal Circulatory System is Irreducibly Complex

Intelligent Design the Future

Play Episode Listen Later Jun 6, 2022 18:36 Very Popular


On today's ID the Future, distinguished British physician and author David Galloway explains why he's convinced that the human fetal circulatory system is irreducibly complex and therefore beyond the reach of blind gradualistic evolution to have built. In his conversation with host and fellow physician Geoffrey Simmons, Galloway also mentions some molecular machines that he's convinced are irreducibly complex and shout intelligent design. The occasion for the conversation is Galloway's new book, Design Dissected. Source

Cancer
A. De Biasio - Human DNA replication under the microscope: Visualizing the lagging strand replisome at high-resolution using cryo-EM

Cancer

Play Episode Listen Later Apr 21, 2022 34:27


Alfredo De Biasio, Assistant Professor, Bioscience, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, SAUDI ARABIA speaks on "Human DNA replication under the microscope: Visualizing the lagging strand replisome at high-resolution using cryo-EM".

The Medbullets Step 1 Podcast
Biochemistry | DNA Replication

The Medbullets Step 1 Podcast

Play Episode Listen Later Dec 9, 2021 11:10


In this episode, we review the high-yield topic of DNA Replication from the Biochemistry section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

Indiana University News
Studying DNA replication errors, and the role of BIPOC progressive prosecutors

Indiana University News

Play Episode Listen Later Nov 10, 2021 4:12


An IUPUI researcher is studying the role of DNA replication errors in cancer formation, and an IU Bloomington criminal justice professor is studying BIPOC progressive prosecutors and their efforts to reform criminal justice.

SciPod
A Twin DNA Replication Factory - Professor Michael O'Donnell, Rockefeller University

SciPod

Play Episode Listen Later Jun 9, 2021 12:03


For life on Earth to grow, its genetic material must be copied and reproduced in a process known as DNA replication. Professor Michael O'Donnell, head of the Rockefeller University's DNA replication laboratory, has devoted his over 30-year career to the study of the protein complex that is responsible for just that – the replisome. Recently, Professor O'Donnell and his team uncovered exciting insights into the function of this remarkable piece of molecular machinery.

My AP Biology Thoughts
DNA Replication

My AP Biology Thoughts

Play Episode Listen Later Jun 2, 2021 5:05


My AP Biology Thoughts  Unit 6 Gene Expression and RegulationWelcome to My AP Biology Thoughts podcast, my name is Morgan and I am your host for episode # 106 called Unit 6 Gene Expression and Regulation: DNA Replication. Today we will be discussing the process by which cells replicate their DNA Segment 1: Introduction to DNA Replication Difference between prokaryotic and Eukaryotic DNA P is one circular piece of dna where eukaryotic are multiple linear chromosomes DNA replication is semi-conservative Double helix is split in two and then each new strand is synthesized so to new double helices are made, each with one old and one new strand  very complex but very fast Extremely accurate (only 1 in a billion bases are messed up) Have to prime the DNA for replication Primers are short molecules that attach to the dna at the origin of replication  Mde by the enzyme primase Helicase is the enzyme that unwinds the double helix- initiates the replication fork (where two strands split apart) Multiple replication forks in eukaryotic dna Topoisomerase checks problems in the DNA before replication and maintains the structure DNA polymerase is the enzyme that synthesizes the new DNA strand- reads the bases and matches up complementary nucleotides Segment 2: More About the process of replication Replication initiation can occur at both directions from the origin where the primer binds DNA polymerase can only add nucleotides in the 5 to 3 prime direction, and read the strand of dna in the 3 to 5 prime direction Leading strand is continuous Lagging strand is discontinuous, has to read and synthesize in short segments (okazaki fragments) Enzyme ligase seals together the fragments Energy needed for this process (remember forming bonds between the nucleotides requires energy)  Segment 3: Connection to the Course Connection to mitosis S phase of mitosis is dna replication Necessary for cell division to make the same amount of chromosomes in daughter cells Process is close to the same for rna synthesis Leading and lagging strands Okazaki fragments and 3 to 5 prime direction vs 5 to 3 prime direction Thank you for listening to this episode of My AP Biology Thoughts. For more student-ran podcasts and digital content, make sure that you visit http://www.hvspn.com (www.hvspn.com).  Music Credits: "Ice Flow" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/ Subscribe to our Podcast https://podcasts.apple.com/us/podcast/my-ap-biology-thoughts/id1549942575 (Apple Podcasts) https://open.spotify.com/show/1nH8Ft9c9f6dmo75V9imCk (Spotify) https://podcasts.google.com/search/my%20ap%20biology%20thoughts (Google Podcasts )   https://www.youtube.com/channel/UC07e_nBHLyc_nyvjF6z-DVg (YouTube)   Connect with us on Social Media Twitterhttps://twitter.com/thehvspn ( @thehvspn)

The Biotech Podcast
#6 - Dr Bruce Alberts: Scientific education, DNA replication and Watson and Crick

The Biotech Podcast

Play Episode Listen Later Jan 7, 2021 71:54


Having worked with the likes of Freeman Dyson, we hear about the incredible achievements of Dr Bruce Alberts, winner of both the National medal of science in 2014 and the Lasker award in 2016. If you are interested in helping The Biotech Podcast please take 30 seconds to take the following survey: https://harry852843.typeform.com/to/caV6cMzGFull synopsis:00:00 - Intro01:30 - The scientific process09:51 - Scientific thinking and education24:25 - Writing 'Molecular biology of the cell', its intentions and its impacts41:32 - DNA replication - mechanisms, evolution and discovering the biochemistry1:03:54 - Book recommendations and advice1:08.09 - Freeman Dyson, Leroy Hood and the Human Genome project

Teach Me Biology
DNA Replication

Teach Me Biology

Play Episode Listen Later Dec 10, 2020 25:35


This week we discuss DNA Replication.Find us on the internet!Our website - Teachmescience.co.ukEmail - teachmebiologycast@gmail.comTwitter - twitter.com/teachmebiocastInstagram - @teachmebiologycast

PaperPlayer biorxiv biochemistry
Multistep mechanism of DNA replication-coupled G-quadruplex resolution

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Nov 11, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.11.378067v1?rss=1 Authors: Sato, K., Martin-Pintado, N., Post, H., Altelaar, M., Knipscheer, P. Abstract: G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that is coupled to DNA replication. First, the replicative helicase (CMG) stalls at a leading strand G4 structure. Second, the DHX36 helicase mediates the bypass of the CMG past the intact G4 structure, which allows approach of the leading strand to the G4. Third, G4 structure unwinding by the FANCJ helicase enables the DNA polymerase to synthesize past the G4 motif. A G4 on the lagging strand template does not stall CMG, but still requires DNA replication for unwinding. DHX36 and FANCJ have partially redundant roles, conferring robustness to this pathway. Our data reveal a novel genome maintenance pathway that promotes faithful G4 replication thereby avoiding genome instability. Copy rights belong to original authors. Visit the link for more info

MCAT Modules - Review
4:8. Speed and Precision of DNA Replication

MCAT Modules - Review

Play Episode Listen Later Jun 21, 2020 0:44


USELESS MODULE // I didn't think I'd actually get it to 45 seconds LOL

MCAT Modules - Review
4:6. The DNA Replication Process

MCAT Modules - Review

Play Episode Listen Later Jun 20, 2020 4:54


(Yes it has a different name). The 8-step process.

The APsolute RecAP: Biology Edition
The APsolute Recap: Biology Edition - DNA Replication

The APsolute RecAP: Biology Edition

Play Episode Listen Later Apr 1, 2020 6:42


Melanie recAPs DNA Replication by reviewing the role of enzymes. DNA Replication is semiconservative and occurs during the S phase of the cell cycle in eukaryotic cells (1:20). How does the structure of DNA influence the process of replication? (1:40) The CED requires you to know the function of the following enzymes: topoisomerase (2:38), helicase (2:48), DNA polymerase (3:25), and ligase (4:35). There are distinctions between replication patterns in prokaryotes and eukaryotes (5:00).The Question of the Day asks (5:39) “What is the condensed, identical DNA strand called during mitosis?”Thank you for listening to The APsolute RecAP: Biology Edition!(AP is a registered trademark of the College Board and is not affiliated with The APsolute RecAP. Copyright 2020 - The APsolute RecAP, LLC. All rights reserved.)Website:www.theapsoluterecap.comEMAIL:TheAPsoluteRecAP@gmail.comFollow Us:INSTAGRAMTWITTER

Anatomy and Physiology - Bit by Bit
Episode 7 - DNA Replication And Cell Cycle

Anatomy and Physiology - Bit by Bit

Play Episode Listen Later Feb 25, 2020 13:41


This episode covers DNA replication and the cell cycle.

Evolving with Mr. V
Episode 19 Week 19 AP/DC Biology

Evolving with Mr. V

Play Episode Listen Later Jan 20, 2020 25:30


In this week's episode we look back at the 2nd week of the 2nd Semester and review the biggest concepts and activities over DNA Replication that were covered in class. In our 2nd segment I share some advice on ways to study and hints for the upcoming Ch. 11 and Ch. 16 Exam...Furthermore I announce a Study Session taking place to help those students who might want some extra help studying for the Upcoming Cell Communication and DNA Exam. In addition, in our new segment in the podcast called 5 Questions with Mr. V...I'll interview another special guest a hero, educator, and around great person Mr. Mora and ask him 5 questions so the audience gets to know him just a little bit better. Remember to subscribe, like, and please comment on the podcast on your podcast listening platform. You can also e-mail me at ovelas@neisd.net with any comments or feedback. You can also follow me on twitter at OscarVelasquez@APBiologyMrV. Students can always contact me and communicate with me via the Edmodo course website or APP. If you have questions you would like Mr. V to answer please e-mail me the questions or send them on Edmodo or Twitter. Also follow the new Instagram Page for the podcast "Evolving with Mr. V". I want to thank you for listening...I am your Host Mr. Oscar Velasquez "Master of the Biological Arts". Have a Great Week and May the Force be With You...I have Spoken. Big Shout Out to Free Music Achieve and SoundBible for the music and sound effects in the podcast.

ProspectiveDoctor's MCAT Basics
DNA Replication and Central Dogma

ProspectiveDoctor's MCAT Basics

Play Episode Listen Later Jul 1, 2019 50:46


This podcast covers DNA replication and central dogma. First, I breakdown DNA replication, discussing: conservative, semi-conservative, and dispersive replication, and the DNA replication mechanism. Then, I discuss transcription and translation, including: differences between prokaryotes and eukaryotes, mechanisms, and cellular location. Please email me if you have any comments or concerns: sasm6771@colorado.edu Thanks for listening!

Revise - A Level Biology Revision
A Level Biology - DNA Replication

Revise - A Level Biology Revision

Play Episode Listen Later May 8, 2019 6:14


Liz looks at DNA replication for your A Level Biology exam. In this episode, she will look at semi-conservative DNA replication, the enzymes involved in replication and the different models for DNA replication. Ideal for preparing for your A Level Biology exam. For more info visit https://www.senecalearning.com/blog/a-level-biology-revision/

ACS Research - TheoryLab
Deep dive into DNA replication and repair

ACS Research - TheoryLab

Play Episode Listen Later Apr 30, 2019 16:25


Alex Wu is an American Cancer Society Postdoctoral Fellow in Johannes Walter's lab at Harvard Medical School, where he and his colleagues are focused on investigating the mechanisms of genome maintenance. In this conversation he goes deep into the science behind several of their recent publications, including a Nature paper in which they showed that TRAIP is a master regulator of DNA interstrand crosslink repair.

Medical School Audio
FTM16 DNA Replication 1

Medical School Audio

Play Episode Listen Later Mar 6, 2018 46:19


(Biochemistry) --- Support this podcast: https://anchor.fm/brad-richardson/support

Medical School Audio
FTM17 DNA Replication 2

Medical School Audio

Play Episode Listen Later Mar 6, 2018 56:19


(Biochemistry) --- Support this podcast: https://anchor.fm/brad-richardson/support

MrBiology360 Podcast
Chapter 12-2 DNA Replication

MrBiology360 Podcast

Play Episode Listen Later Jan 24, 2018 4:31


Chapter 12-2 DNA Replication by MrBiology360

IFOM 2015
DNA replication and repair in vertebrate cells

IFOM 2015

Play Episode Listen Later Aug 9, 2017 7:56


Dr Costanzo talks to ecancertv at IFOM EMBL about vertebrate genome stability, focusing on the DNA replication and repair in vertebrate cells. Additionally he discusses his research using extracts derived from Xenopus laevis eggs, which allow extensive biochemical analysis which can be reproduced in vitro complex cell cycle events such as chromatin formation, nuclear assembly, semi-conservative DNA replication, chromosome assembly and mitotic spindle formation.

BIO 101-01W Fall 2016
Oct 17 BIO 101 DNA Replication - 10:17:16, 11.13 AM

BIO 101-01W Fall 2016

Play Episode Listen Later Oct 20, 2016 41:08


At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
I. Whitehouse - Coupling of gene enhancers and replication origins

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 30, 2016 22:55


Iestyn Whitehouse, Memorial Sloan-Kettering CC, New York, speaks on "Coupling of gene enhancers and replication origins". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
O. Fernandez-Capetillo - Mechanisms of resistance to anticancer therapies

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 30, 2016 22:58


Oscar Fernandez-Capetillo, Spanish National Cancer Res. Center, Madrid , speaks on "Mechanisms of resistance to anticancer therapies. "This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
S. Mirkin - Mechanisms of genome instability mediated by interstitial telomeric sequences

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 30, 2016 21:35


Sergei Mirkin, Tufts University, Medford, speaks on "Mechanisms of genome instability mediated by interstitial telomeric sequences". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
W. Yang - Molecular gymnastics during DNA translesion synthesis

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 29, 2016 24:44


Wei Yang, NIDDK, NIH, Bethesda, speaks on "Molecular gymnastics during DNA translesion synthesis". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
A. Constantinou - A FANCM protein interaction screen reveals a pyrimidine catabolism enzyme required to prevent cell-intrinsic DNA replication stress

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 29, 2016 20:31


Angelos Constantinou, Institute of Human Genetics, Montpellier, speaks on "A FANCM protein interaction screen reveals a pyrimidine catabolism enzyme required to prevent cell-intrinsic DNA replication stress ". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
J. Berger - Structural mechanisms for initiating DNA replication

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 29, 2016 23:59


James Berger, Johns Hopkins, Baltimore, speaks on "Structural mechanisms for initiating DNA replication". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
P. Pasero - SAMHD1 processes stalled forks and links DNA replication stress to inflammation

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 28, 2016 20:58


Philippe Pasero, Institute of Human Genetics, Montpellier, speaks on "SAMHD1 processes stalled forks and links DNA replication stress to inflammation". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
P. Knipscheer - How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 28, 2016 22:17


Puck Knipscheer, Hubrecht Institute, Utrecht, speaks on "How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
D. Cortez - ETAA1 regulates ATR to maintain genome stability during DNA replication

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 28, 2016 21:29


David Cortez, Vanderbilt University, Nashville, speaks on "ETAA1 regulates ATR to maintain genome stability during DNA replication". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
T. Carr - Mechanisms of replication-associated genome rearrangement

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 28, 2016 22:55


Tony Carr, University of Sussex, Falmer, speaks on "Mechanisms of replication-associated genome rearrangement". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
P. Burgers - The inner workings of the lagging strand maturation machinery

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

Play Episode Listen Later Jun 28, 2016 22:17


Peter Burgers, Washington University, St.Louis, speaks on "The inner workings of the lagging strand maturation machinery". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

15-Minute Eargasm
004: DNA Replication

15-Minute Eargasm

Play Episode Listen Later Apr 22, 2016 15:03


This week Rod & Mig discuss: Doctor Visits Chafing Making Babies Follow…

IFOM Podcasts
Interview with Vincenzo Costanzo, IFOM

IFOM Podcasts

Play Episode Listen Later Aug 28, 2015 8:12


IFOM Podcasts
Interview with Vincenzo Costanzo, IFOM

IFOM Podcasts

Play Episode Listen Later Aug 28, 2015 8:12


OCW Scholar: Fundamentals of Biology

Professor Lander explains DNA Replication, the functions of the enzymes involved, and how problems that arise during replication are addressed.

Translational Medicine
DNA replication and Cancer

Translational Medicine

Play Episode Listen Later Dec 10, 2014 7:05


DNA replication and Cancer The process of DNA replication is complex, and mistakes can lead to genome instability. Surveillance systems are not always successful which results in mutations that have the potential to inactivate genes or change their activity. This can lead to cancer, and many chemotherapeutic drugs are designed to disrupt DNA replication. A better understanding of these mechanisms can help us develop new drugs with reduced side effects.

Genetics
DNA replication and Cancer

Genetics

Play Episode Listen Later Dec 10, 2014 7:05


DNA replication and Cancer The process of DNA replication is complex, and mistakes can lead to genome instability. Surveillance systems are not always successful which results in mutations that have the potential to inactivate genes or change their activity. This can lead to cancer, and many chemotherapeutic drugs are designed to disrupt DNA replication. A better understanding of these mechanisms can help us develop new drugs with reduced side effects.

Crick Memorial Meeting - 60th Anniversary of DNA Structure
Semiconservative DNA replication (Matthew Meselson)

Crick Memorial Meeting - 60th Anniversary of DNA Structure

Play Episode Listen Later Apr 30, 2013 29:51


Science Signaling Podcast
Science Signaling Podcast, 12 February 2013

Science Signaling Podcast

Play Episode Listen Later Feb 11, 2013 13:51


In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions.

Molecular Genetics
J. F.X. Diffley - Investigating how DNA replication initiates in eukaryotes

Molecular Genetics

Play Episode Listen Later Jun 15, 2012 62:46


J. F.X. Diffley Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, UK speaks on "Investigating how DNA replication initiates in eukaryotes". This seminar has been recorded by ICGEB Trieste

Bio to Go Podcasts - Mrs. Balling
DNA Replication Notes (Modern Genetics Unit)

Bio to Go Podcasts - Mrs. Balling

Play Episode Listen Later Mar 28, 2012 0:03


Research Podcast | Memorial Sloan Kettering Cancer Center
2011 Major Trends in Modern Cancer Research

Research Podcast | Memorial Sloan Kettering Cancer Center

Play Episode Listen Later Jan 5, 2012 110:45


Runtime 110:45 Memorial Sloan Kettering President and CEO Craig Thompson along with cancer biologist Andrea Ventura, molecular biologist Iestyn Whitehouse, and developmental biologist Jennifer Zallen explain how recent developments contribute to better treatments for cancer patients. read more

MCB 181 Introductory Biology
MCB 181R 10.7.11 DNA replication

MCB 181 Introductory Biology

Play Episode Listen Later Oct 8, 2011 52:38


What is the genome made of? - for iBooks

Genomes are composed of DNA, and a knowledge of the structure of DNA is essential to understand how it can function as hereditary material. DNA is remarkable, breathtakingly simple in its structure yet capable of directing all the living processes in a cell, the production of new cells and the development of a fertilized egg to an individual adult. DNA has three key properties: it is relatively stable; its structure suggests an obvious way in which the molecule can be duplicated, or replicated; and it carries a store of vital information that is used in the cell to produce proteins. The first two properties of DNA are analysed in this unit. This study unit is just one of many that can be found on LearningSpace, part of OpenLearn, a collection of open educational resources from The Open University. Published in ePub 2.0.1 format, some feature such as audio, video and linked PDF are not supported by all ePub readers.

C2005.001 Intro to Cellular and Molecular Biology - Audio
10. DNA as hereditary material, Nucleic acid structure, Introduction to DNA replication

C2005.001 Intro to Cellular and Molecular Biology - Audio

Play Episode Listen Later Oct 26, 2010 76:03


Dna Repair
A. Dutta - Ubiquitination pathways in the DNA replication and response to DNA damage

Dna Repair

Play Episode Listen Later Aug 31, 2010 56:42


Anindya Dutta, Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA speaks on "Ubiquitination pathways in the DNA replication and response to DNA damage". This seminar has been recorded by ICGEB Trieste

Molecular and Cellular Biology
J. Diffley - Mechanism and Regulation of DNA Replication in Yeast

Molecular and Cellular Biology

Play Episode Listen Later Apr 23, 2010 56:30


John Diffley, Chromosome Replication Laboratory, London Research Institute, Clare Hall Laboratories, South Mimms, London, UK speaks on "Mechanism and Regulation of DNA Replication in Yeast". This seminar has been recorded by ICGEB Trieste

DNA, RNA and protein formation - for iPod/iPhone

Transcript -- How DNA molecules replicate themselves.

DNA, RNA and protein formation - for iPad/Mac/PC

Transcript -- How DNA molecules replicate themselves.

Biologie - Open Access LMU - Teil 02/02
Reversal of terminal differentiation and control of DNA replication

Biologie - Open Access LMU - Teil 02/02

Play Episode Listen Later Jan 1, 1993


DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells. We used this cellular system to analyze the interaction of cell cycle proteins with these foci in vivo. Cyclin A and cdk2, but not cyclin B1 and cdc2, were specifically localized at nuclear replication foci, just like the replication protein proliferating cell nuclear antigen. A potential target of cyclin A and cdk2 is the 34 kd subunit of replication protein A (RPA34). In contrast with the 70 kd subunit, which localizes to the foci, RPA34 was not detected at these replication sites, which may reflect a transient interaction. The specific localization of cyclin A and cdk2 at nuclear replication foci provides a direct link between cell cycle regulation and DNA replication.

Biologie - Open Access LMU - Teil 02/02
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

Biologie - Open Access LMU - Teil 02/02

Play Episode Listen Later Jan 1, 1992


Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but to display a diffuse nucleoplasmic distribution in non-S phase cells. Analysis of DNA MTase-β-galactosidase fusion proteins has shown that association with replication foci is mediated by a novel targeting sequence located near the N-terminus of DNA MTase. This sequence has the properties expected of a targeting sequence in that it is not required for enzymatic activity, prevents proper targeting when deleted, and, when fused to β-galactosidase, causes the fusion protein to associate with replication foci in a cell cycle-dependent manner.

Medizin - Open Access LMU - Teil 07/22
Regulatory structures of gene expression, DNA replication and DNA rearrangement in macronuclear genes of Stylonychia lemnae, a hypotrichous ciliate

Medizin - Open Access LMU - Teil 07/22

Play Episode Listen Later Jan 1, 1989


Sun, 1 Jan 1989 12:00:00 +0100 https://epub.ub.uni-muenchen.de/8666/1/8666.pdf Fritzenschaf, Hariolf; Becker, Karl F.; Conzelmann, Karl-Klaus; Helftenbein, Elke

Medizin - Open Access LMU - Teil 03/22
Mitochondrial DNA Replication Does Not Involve DNA Polymerase alpha

Medizin - Open Access LMU - Teil 03/22

Play Episode Listen Later Jan 1, 1980


Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/5377/1/Zimmermann_Wolfgang_5377.pdf Weissbach, Arthur; Bolden, Arthur; Chen, Shih Min; Zimmermann, Wolfgang ddc:610, Medizin