Podcasts about Mechanism

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Best podcasts about Mechanism

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Latest podcast episodes about Mechanism

High Intensity Health Radio with Mike Mutzel, MS
Your Carb Tolerance Changes with Age, Here's Why

High Intensity Health Radio with Mike Mutzel, MS

Play Episode Listen Later Sep 23, 2022 14:28


Aging is linked with changes in your metabolism and carbohydrate tolerance, here's the must-know details. Support Healthy Hydration and Exercise Performance with the new Electrolyte Stix by MYOXCIENCE Nutrition: https://bit.ly/electrolyte-stix Save with code podcast at checkout Links to studies and videos mentioned: https://bit.ly/3C2aYhR   Shou, J., Chen, P.-J., & Xiao, W.-H. (2020). Mechanism of increased risk of insulin resistance in aging skeletal muscle. Diabetology & Metabolic Syndrome, 1–10. Episode Time Stamps: 0:00 Your ability to process and tolerate carbohydrates declines with age. 0:40 Aging is linked with a decline in skeletal muscle insulin sensitivity. 1:45 Insulin resistance prevalence for those ages 40 to 59 is 40% to 60% and ages 20 to 39 is 20%. Over the age of 75, prevalence is over 75%. 2:35 Autophagy declines with age. There is a reduction in quantity and quality of mitochondria within the muscle, reduced insulin sensitivity and an increase in background inflammation. 03:20 Exercise increases mitophagy, the recycling of mitochondria. 4:45 Loss of fast twitch muscle fibers, associated with ageing, is associated with declines in insulin sensitivity and an increase in inflammation. 5:25 Over age 40, there is an 8% loss of muscle per decade. By age 70, your muscles are 30% smaller than age 20. 5:55 Loss of type 2 fibers causes a loss of strength. 6:20 Strength loss is 25 to 40% per decade after the age of 40. Muscle size lost is about 10% per decade over 40. 6:55 Exercise to improve metabolic health. 7:50 Do explosive, high intensity movements and compound multi muscle movements. 9:40 Periodically, focus on strength, speed, and concentric movement to prevent the preferential loss of type 2 fibers. 13:25 Exercise reduces blood pressure and increases autophagy and mitophagy.    

Women Seeking Wholeness
186: Music as a Healing Mechanism

Women Seeking Wholeness

Play Episode Listen Later Sep 21, 2022 44:11


Music is my main way to connect to the God of my understanding. It creates a quantum field conducive to healing. Mark Romero is an internationally recognized Transformational Sound Healing Expert & Thought Healer. Music has been shown to eliminate negative influences in the environment and help the mind-body operate at optimal levels.    The creative spark that's inside all of us How music helps us command & move our own energy How music can be the carrier wave for intention   Find him: markromeromusic.com

Sigma Nutrition Radio
PRE #9: AMA – Blood Pressure, LDL Lowering, PCOS & More!

Sigma Nutrition Radio

Play Episode Listen Later Sep 20, 2022 15:03 Very Popular


In this Premium-exclusive ‘Ask Me Anything' episode, Alan & Danny answer a range of listener questions. Topics include obesity rates, lowering blood pressure, cholesterol drugs, PCOS, and what issues they have changed their minds on. See the full list of questions below. [02.37] Do you feel that there is hope (or an effective way forward) for obesity rates to come down? Based on your response, why/why not? [11.28] In this field, it seems like so many of us have had positions we've held very seriously that we now see as poorly supported by research, or just have a significant paradigm change. It would be great to hear you look back to how your views have evolved over the years. [30.34] Apart from lowering salt intake and eating foods high in potassium are there other things you can take or do to reduce blood pressure? [40.34] What is the best ratio of DHA vs EPA to increase my Omega 3 index? [46.20] Statins v Ezetimibe: Differences between the two? Mechanism of action? Are there situations, conditions, genetic markers where one may work better than the other? [56.20] I'm starting a PhD in the fall concerning the pathophysiology of metabolic diseases and I'd like to take some courses that would help me in my research. Would you have any recommendations for a beginner scientist? [59.01] Is astaxanthin a good substitute for algae oil for someone who follows a vegan diet? [60.45] Do you have any suggestions how to better manage hunger in obese women with PCOS? [64.33] Do you have any recommendations for anyone wanting to get involved in chrononutrition research? Links: Subscribe to Premium Live Event: Berlin, Germany on November 26th 2022 Episode transcript Resources mentioned in this episode

The King Is Coming Soon
Episode-297: Israel's Government Approved the Negev Forum- A Regional Mechanism, on Sunday September 18, 2022

The King Is Coming Soon

Play Episode Listen Later Sep 20, 2022 30:56


Devotional: Caption: “For Israel has forgotten his Maker and has built temples…” What can nations today learn from Samaria's rejection of God?

PaperPlayer biorxiv neuroscience
A neural mechanism of cognitive reserve: The case of bilingualism

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 20, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.20.508678v1?rss=1 Authors: Stevens, W. D., Khan, N., Anderson, J. A. E., Grady, C. L., Bialystok, E. Abstract: Cognitive Reserve (CR) refers to the preservation of cognitive function in the face of age- or disease-related neuroanatomical decline. While bilingualism is known to contribute to CR, the extent to which, and what particular aspect of, second language experience contributes to CR are debated, and the underlying neural mechanism(s) unknown. Intrinsic functional connectivity reflects experience-dependent neuroplasticity that occurs across timescales ranging from minutes to decades, and may be a neural mechanism underlying CR. To test this hypothesis, we used voxel-based morphometry and resting-state functional connectivity analyses of MRI data to compare structural and functional brain integrity between bilingual and monolingual older adults, matched on cognitive performance using a rigorous propensity score matching technique, and across levels of second language proficiency measured as a continuous variable. Bilingualism, and degree of second language proficiency in particular, were associated with lower grey matter integrity in a hub of the default mode network, a region that is particularly vulnerable to decline in aging and dementia, but preserved functional network organization that resembled the young adult brain. Our findings confirm that lifelong bilingualism contributes to CR through experience-dependent maintenance of optimal functional network structure of the domain-general attentional control network across the lifespan. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Heart to Heart Nurses
Heart Failure Management: SGLT2i and GLP-1 RA Mechanism of Action

Heart to Heart Nurses

Play Episode Listen Later Sep 20, 2022 24:57


[CE contact hours--see below.] Often prescribed for obesity, SGLT2is and GLP-1 RAs have a role in heart failure management. Learn about their mechanisms of action, and how their use extends beyond weight loss to cardioprotective and renalprotective properties. Guests: Kim Newlin, MSN, ANP, FPCNA, of Sutter Roseville Medical Center in Northern California, and Colleen McIlvennan, PhD, DNP, ANP, FAHA, FHFSA, from the University of Colorado in Denver. CE Link: https://pcna.net/?p=10718&post_type=online-course&preview_id=10718 2022 AHA/ACC/HFSA 2022 Guideline for the Managment of HF: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063Pocket Guide: Guidelines for Managing CVD Risk in Patients with Diabetes: https://pcna.net/clinical-resources/provider-tools/diabetes-provider-tools/HF Pocket Guide: A Guide to Prevention and Management: https://pcna.net/clinical-resources/provider-tools/heart-failure-provider-tools/ New and Emerging Treatments for Heart Failure: HFrEF and HFpEF (CE course): https://pcna.net/online-course/new-and-emerging-treatments-for-heart-failure-hfref-and-hfpef/ SGLT2is in Heart Failure: ncbi.nlm.nih.gov/pmc/articles/PMC8654149/SGLT2i in HFpEF: multicenter randomized trial: nature.com/articles/s41591-021-01536-xEmpagliflozin in HFpEF: https://www.nejm.org/doi/10.1056/NEJMoa2107038#:~:text=Empagliflozin%20in%20HF%20with%20Preserved%20Ejection%20Fraction&text=Sodium%E2%80%93glucose%20cotransporter%202%20(SGLT2,and%20a%20reduced%20ejection%20fraction. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

DISRESPECTFUL NAJA_SORRY NOT SORRY!
The mainstream of modern thought has, of course, led in the opposite direction. Reductionist mechanism aspires to corner the mind into some

DISRESPECTFUL NAJA_SORRY NOT SORRY!

Play Episode Listen Later Sep 19, 2022 1:41


PaperPlayer biorxiv neuroscience
A T1R-independent mechanism for responses to hyperosmotic sugars involves a carbonic anhydrase-sensitive mechanism in Type III receptor cells

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 19, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.16.508275v1?rss=1 Authors: Kalyanasundar, B., Blonde, G., Spector, A. C., Travers, S. P. Abstract: Recent findings from our laboratory demonstrated that the rostral nucleus of solitary tract (rNST) retains some responsiveness to glutamate (MSG+amiloride-MSGa) and sugars in mice lacking the canonical T1R receptors for these tastants. Here, we recorded from the parabrachial nucleus (PBN) in mice lacking the T1R1+T1R3 heterodimer (KO1+3), using warm stimuli to optimize sugar responses and employing extended concentrations and pharmacological agents to probe mechanisms. MSGa+IMP responses were not synergized in KO1+3 mice but responses to MSGa were similar to those in B6 (WT) mice. Glutamate responses in the neurons tested were unaffected by topical application of an mGluR4 antagonist. PBN T1R-independent sugar responses, including those to concentrated glucose, were more evident than in rNST. Sugar responses were undiminished by phlorizin, an inhibitor of SGLT, a component of a hypothesized alternative glucose-sensing mechanism. There were no sugar/umami "best" neurons in KO1+3 mice, and instead, sugars activated cells that displayed acid and amiloride-insensitive NaCl responses. In WTs, concentrated sugars activated "sugar/umami" cells but also electrolyte-sensitive neurons. The efficacy of hyperosmotic sugars for driving neurons broadly responsive to electrolytes implied an origin from Type III taste bud cells. To test this, we used the carbonic anhydrase (CA) inhibitor dorzolamide (DRZ), previously shown to inhibit amiloride-insensitive sodium responses arising from Type III cells. Dorzolamide had no effect on sugar-elicited responses in WT sugar/umami PBN neurons but strongly suppressed them in WT and KO electrolyte-generalist neurons. These findings suggest a novel T1R-independent mechanism for hyperosmotic sugars, involving a CA-dependent mechanism in Type-III taste bud cells. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

ZenChats with Zeneca
#42 Moodies - Innovation In A Disruptive Industry, Pay-What-You-Feel Minting Mechanism

ZenChats with Zeneca

Play Episode Listen Later Sep 19, 2022 38:40


Tomer and Asaf Hanuka are today's Zenchats guests!They created Moodies, an innovative pay-what-you-feel NFT Project, and we talked about their Web3 story, their new minting experience, what's next in the Moodiesverse, and more!I hope you enjoy this episode with Moodies, and please consider subscribing to the podcast and leaving a review - it really helps 

The Beautifully Broken Podcast
Nitric Oxide as the ultimate Signaling Molecule for Whole Body health with Dr. Nathan Bryan

The Beautifully Broken Podcast

Play Episode Listen Later Sep 19, 2022 45:32


We're Back! Welcome to Season 5What if I told you that there's a single molecule that regulates blood pressure, transmits signals between neurons, and suppresses pathogens? The new science indicates nitric oxide is capable of all of this and more.In this episode, we are joined by Dr. Nathan Bryan as he illustrates how Nitric Oxide is produced in the body and why it is one of the most important molecules for the robust health of blood vessels. Dr. Bryan received a Bachelor of Science in Biochemistry as an undergraduate from the University of Texas at Austin and a Doctor of Philosophy from Louisiana State University. Dr. Bryan has written 5 books in addition to a number of highly regarded articles. He is a pioneer in the fields of nitric oxide biochemistry and molecular medicine worldwide.His Book: Functional Nitric Oxide Nutrition highlights new science that is not considered by most physicians and healthcare practitioners so patients and consumers can use this information and new knowledge to take control of their own health. The objectives are to educate readers on the importance of nitric oxide, to clearly illustrate that diet and lifestyle modifications can significantly improve nitric oxide production, and to arm the reader with information they can begin to implement into their daily life.Fun Fact: Loss of nitric oxide is the earliest event in the onset and progression of most, if not all, chronic diseases. As we age, we lose the ability to produce nitric oxide, putting us at risk for age-related disease. This is an episode this audience does not want to miss!HIGHLIGHTS[2:32] Importance of Nitric Oxide[6:47] Nitric Oxide's Mechanism of action in the body[11:14] Intervention of Nitric Oxide for Myocarditis[13:30] Consumer's Guide for Nitric Oxide[17:20] Role of Nitric Oxide in Chronic Illness[20:38] Nitric Oxide Technology[23:43] How do Cells heal?[30:40] What is Healing?[33:36] The Future of Health and Medicine[35:12] Dr. Bryan's ProductsThis episodes product: https://no2u.com/Code: BEAUTIFULLYBROKENCONNECT WITH DR. NATHANWebsite: https://drnathansbryan.com/Email: nathan@drnathansbryan.comLinkedin: https://www.linkedin.com/in/drnathansbryan/Instagram: https://www.instagram.com/drnathansbryanUPGRADE YOUR WELLNESSClaim your free toxicity consult through this LINKAMD Ion Cleanse: https://calendly.com/ioncleanse/detoxSilver Biotics:https://bit.ly/3JnxyDDCode: BEAUTIFULLYBROKENDIY Home Cold Exposure: https://www.penguinchillers.com/product/beautifullybroken/Cellcore – https://www.beautifullybroken.world/affiliate-products My favorite BindersRe-Origin Limbic Training: https://re-origin.com/?ref=18Code: beautifullybrokenLightPath LED https://lightpathled.com/?afmc=BEAUTIFULLYBROKENDiscount Code – beautifullybrokenBioStrap: https://biostrap.com/order-evo?ref=freddiekimmelp My Favorite Recovery TrackerDiscount: BEAUTIFULLYBROKENFully Vital Hair Restoration: https://fullyvital.com/BEAUTIFULLYBROKEN15My Favorite Sauna: Therasage https://bit.ly/39mTxwYCode: BEAUTIFULLYBROKENCONNECT WITH FREDDIECheck out my website and store:www.beautifullybroken.worldJoin my membership program –https://www.buymeacoffee.com/freddiesetgoInstagram – https://www.instagram.com/freddiesetgo/

America's Dead
The Strange Hippie Default Mechanism, with Sam Cutler

America's Dead

Play Episode Listen Later Sep 15, 2022 20:12


“The Grateful Dead viewed the very idea of planning as being some kind of fascist concept” says Sam Culter, the Dead's tour manager from 1969 to 1974. Cutler is the guy who finally turned the Dead into a business, but it was an uphill battle the whole way. “The business model was made essentially by a kind of strange hippie default mechanism that worked in mysterious ways.” In this episode, stories from inside the strange hippie default mechanism. Emmett sits down with Sam Cutler and the stories get… pretty unbelievable. Credits:America's Dead is produced by work by work: Scott Newman, Jemma Brown, Kathleen Ottinger, Alex Kapelman, and Ben Montoya. Additional production from Josh Agajanian. The show is mixed by Sam Bair and Josh Hahn. Our theme music is by Jake Longstreth, John Nixon, Aaron Olson, and Ryan Adlaf of Mountain Brews and Richard Pictures. The show art is created by Andy J. Pizza. Special thanks to Joe Dawson at Sonos. 

Rebel Guru Radio
S2 E34, Mastering the Mechanism: Dimensional Traveling - How To Build An Energy Body And Move Your Consciousness Into Higher Planes of Light

Rebel Guru Radio

Play Episode Listen Later Sep 14, 2022 100:38


This latest series is a compendium of conversations with Eric, recordings that span over a 20-year period. Before the days of smartphones, friends and students maintained a tradition of recording Eric when he would start teaching. Notice: The material was done in a natural environment, passionately, unrehearsed, and unscripted. Audio recordings may include occasional pets, people talking, and adult language. If you are seeking the real deal, you've found it.What is Mastering the Mechanism All About?Mastering the Mechanism is a groundbreaking program that teaches you how to build an energy body that can slip past the restrictions of this reality and explore the next. In this program, Eric shares his knowledge of the mechanics of the universe and shows you how to use this information to build a body that is not bound by the limitations of our physical world. With Mastering the Mechanism, you will be able to move to other dimensions, access hidden knowledge, and gain a greater understanding of the universe. This program is truly life-changing and will enable you to experience things that you never thought possible.Like this episode? If you're interested in attending live classes and refining your knowledge and techniques along with other like-minded people - Eric Pepin's Patreon has Live Weekly classes with the Rebel Guru himself. These classes are centered on spiritual concepts and techniques taught within the Higher Balance curriculum. It is designed to bring perspective and clarity to the earnest spiritual seeker and to dive into the practice and application of these same techniques.Become a Patron here for as little as $1! - https://www.patreon.com/EricPepin  Get bonus content on PatreonSupport this show http://supporter.acast.com/rebelgururadio. Hosted on Acast. See acast.com/privacy for more information.

In Search Of More
Self Healing Mechanism

In Search Of More

Play Episode Listen Later Sep 13, 2022 14:50


Sometimes, it can feel like every area of our life needs an overhaul. How can we get to it all? How will there be enough time to get to all of it? Lucky for us, healing doesn't require us to address every single issue.

PaperPlayer biorxiv neuroscience
Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 9, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.08.507162v1?rss=1 Authors: Leung, C. S., Rosenzweig, S., Yoon, B., Marinelli, N. A., Hollingsworth, E. W., Maguire, A. M., Cowen, M. M., Schmidt, M., Imitola, J., Uzun, E. D. G., Lizarraga, S. B. Abstract: Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are overrepresented among genes that contain high risk variants in ASD. Disruption of the chromatin environment leads to widespread dysregulation of gene expression, which is traditionally thought as a mechanism of disease pathogenesis associated with ASD. Alternatively, alterations in chromatin dynamics could also lead to dysregulation of alternative splicing, which is understudied as a mechanism of ASD pathogenesis. The anticonvulsant valproic acid (VPA) is a well-known environmental risk factor for ASD that acts as a class I histone deacetylase (HDAC) inhibitor. However, the precise molecular mechanisms underlying defects in human neuronal development associated with exposure to VPA are understudied. To dissect how VPA exposure and subsequent chromatin hyperacetylation influence molecular signatures involved in ASD pathogenesis, we conducted RNA sequencing (RNA-seq) in human cortical neurons that were treated with VPA. We observed that differentially expressed genes (DEGs) were enriched for mRNA splicing, mRNA processing, histone modification, and metabolism related gene sets. Furthermore, we observed widespread increase in the number and the type of alternative splicing events. Analysis of differential transcript usage (DTU) showed that exposure to VPA induces extensive alterations in transcript isoform usage across neurodevelopmentally important genes. Finally, we find that DEGs and genes that display DTU overlap with known ASD-risk genes. Together, these findings suggest that, in addition to differential gene expression, changes in alternative splicing correlated with alterations in the chromatin environment could act as an additional mechanism of disease in ASD. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Brilliant Perspectives
Practicing the Pause Button of Self-Control

Brilliant Perspectives

Play Episode Listen Later Sep 8, 2022 9:06 Very Popular


God loves the interactions where His indwelling spirit rises up into the circumstances of life and takes charge because His nature takes us to a higher level. In this episode, we'll be looking at... + Why it's so important TO HIT the pause button when you find negativity in your thinking or acting… + The special role of self-control in putting a negative on PERMANENT HOLD... + How you can OVERCOME any current negative situation in your life as a new creation… + How FREEDOM is accessible in all our circumstances… Key Scripture… + Galatians 5:22-23 - “But the fruit of the Spirit is love, joy, peace, patience, kindness, goodness, faithfulness, gentleness, self-control; against such things there is no law.” To Order the Book... The Nature of Freedom is available in hard copy and as an ebook at Brilliant Book House with special pricing available in bundles of 5. To watch the movie clip, Clear the Mechanism, click here → To Stay Connected With Brilliant CLICK HERE. As always, thanks for listening!

PaperPlayer biorxiv neuroscience
Cognition through internal models: Mirror neurons as one manifestation of a broader mechanism

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 8, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.06.506071v1?rss=1 Authors: Aflalo, T., Chivukula, S., Zhang, C., Rosario, E. R., Pouratian, N., Andersen, R. A. Abstract: Cognition relies on transforming sensory inputs into a more generalizable understanding. Mirror neurons are proposed to underlie this process, yet they fail to explain many key features of human thinking and learning. Here we hypothesize that mirror-like responses are one limited view into a more general framework by which internal models of the world are built and used. We recorded populations of single neurons in the human posterior parietal cortex as a participant felt or observed diverse tactile stimuli. We found that mirror-like responses were fragile and embedded within a richer population response that encoded generalizable and compositional features of the stimuli. We speculate that populations of neurons support versatile understanding, not through mirroring, but instead by encoding representational building blocks of cognition. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Astro arXiv | all categories
Long-term forcing of Sun's coronal field, open flux and cosmic ray modulation potential during grand minima, maxima and regular activity phases by the solar dynamo mechanism

Astro arXiv | all categories

Play Episode Listen Later Sep 7, 2022 1:05


Long-term forcing of Sun's coronal field, open flux and cosmic ray modulation potential during grand minima, maxima and regular activity phases by the solar dynamo mechanism by Soumyaranjan Dash et al. on Wednesday 07 September Magnetic fields generated in the Sun's interior by the solar dynamo mechanism drive solar activity over a range of time-scales. While space-based observations of the Sun's corona exist only for few decades, direct sunspot observations exist for a few centuries, solar open flux and cosmic ray flux variations can be reconstructed through studies of cosmogenic isotopes over thousands of years. While such reconstructions indicate the presence of extreme solar activity fluctuations in the past, causal links between millennia scale dynamo activity, consequent coronal field, solar open flux and cosmic ray modulation remain elusive. By utilizing a stochastically forced solar dynamo model we perform long-term simulations to illuminate how the dynamo generated magnetic fields govern the structure of the solar corona and the state of the heliosphere -- as indicated by variations in the open flux and cosmic ray modulation potential. We establish differences in the nature of the large-scale structuring of the solar corona during grand maximum, minimum, and regular solar activity phases and simulate how the open flux and cosmic ray modulation potential varies over time scales encompassing these different phases of solar activity. We demonstrate that the power spectrum of simulated and reconstructed solar open flux are consistent with each other. Our study provides the theoretical basis for interpreting long-term solar cycle variability based on reconstructions relying on cosmogenic isotopes and connects solar internal variations to the forcing of the state of the heliosphere. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2208.12103v2

Astro arXiv | all categories
Long-term forcing of Sun's coronal field, open flux and cosmic ray modulation potential during grand minima, maxima and regular activity phases by the solar dynamo mechanism

Astro arXiv | all categories

Play Episode Listen Later Sep 7, 2022 1:04


Long-term forcing of Sun's coronal field, open flux and cosmic ray modulation potential during grand minima, maxima and regular activity phases by the solar dynamo mechanism by Soumyaranjan Dash et al. on Wednesday 07 September Magnetic fields generated in the Sun's interior by the solar dynamo mechanism drive solar activity over a range of time-scales. While space-based observations of the Sun's corona exist only for few decades, direct sunspot observations exist for a few centuries, solar open flux and cosmic ray flux variations can be reconstructed through studies of cosmogenic isotopes over thousands of years. While such reconstructions indicate the presence of extreme solar activity fluctuations in the past, causal links between millennia scale dynamo activity, consequent coronal field, solar open flux and cosmic ray modulation remain elusive. By utilizing a stochastically forced solar dynamo model we perform long-term simulations to illuminate how the dynamo generated magnetic fields govern the structure of the solar corona and the state of the heliosphere -- as indicated by variations in the open flux and cosmic ray modulation potential. We establish differences in the nature of the large-scale structuring of the solar corona during grand maximum, minimum, and regular solar activity phases and simulate how the open flux and cosmic ray modulation potential varies over time scales encompassing these different phases of solar activity. We demonstrate that the power spectrum of simulated and reconstructed solar open flux are consistent with each other. Our study provides the theoretical basis for interpreting long-term solar cycle variability based on reconstructions relying on cosmogenic isotopes and connects solar internal variations to the forcing of the state of the heliosphere. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2208.12103v2

AAD's Dialogues in Dermatology
Bonus: Mechanism of Action Approach to Acne Treatment - Combination Therapy Targeting Root Causes (Sponsored by Almirall)

AAD's Dialogues in Dermatology

Play Episode Listen Later Sep 6, 2022


Julie Claire Harper, MD, FAAD interviewed by Katherine Avery Gordon, MD, FAAD

Justin Riddle Podcast
#28 - Quantum Teleportation: a possible mechanism for life after death?

Justin Riddle Podcast

Play Episode Listen Later Sep 5, 2022 51:55


In episode 28 of the Quantum Consciousness series, Justin Riddle describes how quantum teleportation works and wonders whether a quantum computer mind could be teleported out of the body. The episode begins with a discussion of the bizarre, yet common, experience of leaving one's body during a traumatic event to observe the unfolding of events from the outside. These near-death experiences are baffling to scientists, and often dismissed as an unusual chemical or electrical fluctuation in the brain. However, within the quantum computational framework there is a genuine way to teleport quantum information between physical systems. If we were to discover that the human mind is indeed a quantum computer within the brain, then it is at least possible, if not likely, that the mind could teleport outside of the brain. In this episode, the basic component for how to entangle quantum bits and how to teleport quantum information between quantum bits is described. Then, the biological plausibility of teleporting quantum information within the brain is explored. The episode wraps up with a discussion on the nature of quantum information and speculations on the possibility of future forms of computation that utilize the fractal organization of biological systems. Finally, the phenomenon of reincarnation and the possibility of life after the death of the body are pondered. Does the impossible only seem impossible because we have yet to create the technology to replicate the mysteries of nature?

Energy Is Love Podcast
ELP 332- Cope this mechanism

Energy Is Love Podcast

Play Episode Listen Later Sep 1, 2022 71:58


Deep dive into our coping mechanisms and how we're still working through them. Towards the end of the episode, Craig touches upon deep inner child trauma around being alone and Steph supports him through a big emotional release. Enjoy!   If you resonate with the podcast and want to work with us, reach out to learn more about our couples coaching practice. https://energyislove.love/couples-coaching   Facebook- https://www.facebook.com/energyislovelove Instagram- https://www.instagram.com/energy_is_love/ https://energyislove.love/

The Charro Azteca Podcast
INTENTION + MECHANISM = RESULTS | Ep. #90

The Charro Azteca Podcast

Play Episode Listen Later Aug 29, 2022 50:54


100% intention + 0% mechanism = 100% results. When your intention is 100% clear the mechanism appears. If you have a burning desire to do something the mechanism will appear. You will do anything by any means to get the job done or the goal done within a time frame.  

Cities and Memory - remixing the sounds of the world
Tascam 32 Transport Mechanism Tape Machine

Cities and Memory - remixing the sounds of the world

Play Episode Listen Later Aug 27, 2022 0:55


1980s Tascam 32 Tape machine transport mechanism. Play, stop fast forward and rewind including tape flapping where the machine carried on rewinding! Recording provided by Simon Woods. This is part of the Obsolete Sounds project, the world's biggest collection of disappearing sounds and sounds that have become extinct – remixed and reimagined to create a brand new form of listening. Explore the whole project at https://citiesandmemory.com/obsolete-sounds

Cities and Memory - remixing the sounds of the world
Sony TC377 Transport Mechanism Tape Machine

Cities and Memory - remixing the sounds of the world

Play Episode Listen Later Aug 27, 2022 0:49


1970s Sony TC377 Tape Recorder transport mechanism. Play, stop, fast forward etc. Recording provided by Simon Woods. This is part of the Obsolete Sounds project, the world's biggest collection of disappearing sounds and sounds that have become extinct – remixed and reimagined to create a brand new form of listening. Explore the whole project at https://citiesandmemory.com/obsolete-sounds

Fix Yourself First with Dr. Kristie
168. Why Relationships Don't Have To Be as Hard as We Make Them

Fix Yourself First with Dr. Kristie

Play Episode Listen Later Aug 25, 2022 13:45


In this episode Dr. Kristie talks about past and current relationships. How she discovers more about herself and what her needs, goals, and desires are. What We Discuss:Several patterns of self sabotageThe fear of what others would thinkThe advantages of being Vulnerable as well as its challengesWe've got to work on being more vulnerableTake a look at Rooted trust issues What you wanna do is examine, am I projecting? Am I being overly anxious?The third thing that we do that makes relationships hardly; we're really good at pointing the finger saying like your partner were the problemResentment and frustration will get us nowhereWhat are you doing to take care of yourself

Forager Health Podcast
Sean Wattenbarger DC - Healthy Guts and Open Hearts

Forager Health Podcast

Play Episode Listen Later Aug 25, 2022 118:05


Sean Wattenbarger DC joins me on the show this week! Sean is a world class chiropractor with an exceptional depth of understanding and wisdom when it comes to human health. He is one of the most innovative, imaginative, and introspective healthcare practitioners I have ever met. What truly sets him apart in my eyes is the amount of heart he brings to his adjusting table. Listening to this conversation, you will understand what I mean.  We Discuss: The art, science, and possibilities of Bio Geometric Integration Finding satisfaction in our accomplishments and the results of our work in the face of never ending expectations, be they self imposed or otherwise.  Why Sean continues to invest lots of time and energy in extracurricular education many years after graduating with his doctorate degree Mechanisms of Healing in Chiropractic facilitation (what the heck happens when we lay hands on each other, and what potentially can happen) Some of Sean's greatest influences in expanding his foundations for wisdom and truth seeking What Sean hopes to bring into people's lives when they lay on his adjusting table The importance of healthy guts and open hearts A Chiropractor's perspective on C0>!d 19 And more!!! Time Markers: @Start - 24:13 Introductions and Sean's History of Finding his Potential in the Chiropractic Profession @24:13 - 35:41 Enjoying Life and Finding Satisfaction in Our Success in the Face of Never Ending Expectations @35:41 - 52:26 Endless Education - Why Sean Continues to Invest so much Time, Energy, and Attention into Learning, Years after his Licensure as a Doctor @52:26 - 59:11 The Mechanism of Healing and Increasing of Awareness through Shared Experience of Energetic Interface with Mentors and Gurus - What the Heck Happens during Hands on Healing Workshops… @59:11 - 1:06:16 Some of Sean's Greatest Influences and Resources for Growth in Knowledge and Wisdom. @1:06:16 - 1:17:07 What The Adjustment Brings into People's Lives @1:17:07 - 1:23:23 Healthy Guts and Open Hearts - Experiences of Healing through the Clearing of Our Vessels  @1:23:23- 1:53:29 A Chiropractor's Perspective and Experiences within the The Covid Narrative  @1:53:29 - Closing Thoughts on What is Important Enough to Fight for and Love with All Our Hearts in this World  Show Notes: https://www.facebook.com/sean.wattenbargerdc.1 (Sean Wattenbarger DC on Facebook) https://www.drseanchirokc.com/ (Chrysalis Chiropractic Kansas City)

Raised on Real Estate
Just Don't Worry About It! A discussion on a major blocking mechanism in our lives.

Raised on Real Estate

Play Episode Play 57 sec Highlight Listen Later Aug 24, 2022 36:53


Greetings and welcome back to another episode on the RORE platform. Greg Angello with a non-real estate podcast! That's right. This one is an extension of the conversation we had this morning, Wednesday, August 24th and the topic was, "Don't be a worry wort," hence the title. Worry is something that is prevalent in all our lives, unfortunately - or does it have to be? In this episode, I discussed on our Mindset Motivation call, what took place and ways we can overcome the almost-ingrained-verbiage of the word "worry." We use it almost without thinking. What are you worrying about? Can worrying change anything, add anything, do anything effective in our lives? No! It takes up time, wasteful energy, with no solutions, closures or resolutions.  Take a listen and find out four important tools to use to combat worry, the word of it, the thought of, dwelling on it, and refocusing in a different direction. I'm sure you will take something from this one!Don't forget about Send Out Cards!! You have to check it out! Here are the links to check out SOC and it's programs, catalog cards, gifts, and pricing.https://www.SendOutCards.com/u/gjangellohttps://www.SendOutCards.com/u/gjangello/businesshttps://www.sendoutcards.com/app/pricingSOC on Facebookhttps://www.facebook.com/SendOutCards/Also, each and every Monday through Friday -- 8:15 am to 8:30 am -- Mindset Motivation Live on Facebook and Zoom. Come be part of it.http://www.brockzevanmindsetmotivationalcall.com LIVE on ZOOM, Facebook. Our Facebook Page https://www.facebook.com/groups/345937187677114Thank you to all our RORE listening community! We so much thank each and every one of you!!Gregory Angello is the host and producer of Raised on Real Estate. All rights reserved. A Planet One Radio Production.

Future Commerce  - A Retail Strategy Podcast
Web3 Provides a Mechanism for Loyalty

Future Commerce - A Retail Strategy Podcast

Play Episode Listen Later Aug 24, 2022 39:05


In this episode, we dive into some of the best moments of the last year and a half of Future Commerce as it pertains to Web3. Tune in now!Giving Consumers Control Over Their Identity “Like everything else with new technology, the technology's awesome, but until you find creative people to use it in really interesting ways, it doesn't do a whole lot.” – Michael JaniakMags is someone who is thinking about the future of the startup ecosystem. She's passionate about why and how people spend their time, money, and attention“I don't think I'm a consumer brands investor. I don't think I'm a consumer tech investor. I'm a consumer needs investor..” – Magdalena KalaThe journey of NFTs is still early. In many ways, they're very similar to DTC brands as they become easy to launch, and the early movers have made a lot of moneyNFTs signal loyalty. They're a way to assign value to what it means to be associated with a brand.“Hype alone isn't enough to build an enduring brand or community.” There has to be a non-monetary reason that people are engaged in community — for sneakerheads this is the love of the culture and nostalgia that endures well past childhood. Sneakerheads come from many different backgrounds and walks of life. A digital goods community around sneakers may be much more durable than any other PFP (Picture for Proof) project.NFT Project creators are doxxing themselves now to increase optionality. There's a lot more to gain by having a trusted reputation as a person than there is as a cartoon avatar.“I think of the community from which sneakers actually emanate. How can I make it so that anybody can be rewarded even for their participation, for their love of and the passion of whatever that community represents?” – Brandon Martinez“Everything we're doing online has an offline analog. We're reinventing a lot of our everyday normal commerce experiences, but we're doing it in a digital realm. And this is what Web3 unlocks for us; there's nothing new under the sun.” –PhillipAssociated Links:Infinite Shelf Season 1 Episode 8: WEB3 BTC DOA FUD WAGMI: WTFEpisode 240: “Magdalena Kala: "I'm a Consumer Needs and Wants Investor"Episode 262: Building a Web3 Company After the NFT CrashEpisode 266: There's Nothing New Under the SunSubscribe to Insiders and Senses to read more of our hot takes! Download VISIONS 2022 NOW! Listen to our other episodes of Future CommerceCheck out Decoded, our newest limited seriesHave any questions or comments about the show? Let us know on Futurecommerce.fm, or reach out to us on Twitter, Facebook, Instagram, or LinkedIn. We love hearing from our listeners!

UN News
Myanmar citizens show ‘great desire' for justice: Investigative Mechanism chief

UN News

Play Episode Listen Later Aug 23, 2022 14:31


It has been five years since the bloody crackdown in Myanmar that forced nearly one million members of the minority Rohingya community to seek shelter in neighbouring Bangladesh, joining scores of others who had fled previous waves of violence. Nicholas Koumjian heads the International Investigative Mechanism for Myanmar (IIMM), established by the UN Human Rights Council to document crimes committed in the country, including in the wake of the February 2021 military coup. During a recent visit to UN Headquarters, Mr. Koumjian spoke to Dianne Penn about the Mechanism's work, its outreach to Burmese citizens, and the challenges facing its staff. As a veteran prosecutor of international crimes – from Cambodia to Sierra Leone, to the former Yugoslavia and Timor-Leste – Mr. Koumjian is adamant that one day, justice will prevail in Myanmar.  

Interviews
Myanmar citizens show ‘great desire' for justice: Investigative Mechanism chief

Interviews

Play Episode Listen Later Aug 23, 2022 14:31


It has been five years since the bloody crackdown in Myanmar that forced nearly one million members of the minority Rohingya community to seek shelter in neighbouring Bangladesh, joining scores of others who had fled previous waves of violence. Nicholas Koumjian heads the International Investigative Mechanism for Myanmar (IIMM), established by the UN Human Rights Council to document crimes committed in the country, including in the wake of the February 2021 military coup. During a recent visit to UN Headquarters, Mr. Koumjian spoke to Dianne Penn about the Mechanism's work, its outreach to Burmese citizens, and the challenges facing its staff. As a veteran prosecutor of international crimes – from Cambodia to Sierra Leone, to the former Yugoslavia and Timor-Leste – Mr. Koumjian is adamant that one day, justice will prevail in Myanmar.  

The Eastern Front
The Samizdat Mechanism vs. Russian Propaganda (with Yevgeny Simkin)

The Eastern Front

Play Episode Listen Later Aug 19, 2022 36:12


Giselle and Iulia are joined by Yevgeny Simkin, co-founder of "Samizdat Online", an organization which aims to gather all voices of the world that suffer under autocratic repression and reunite those voices with their audiences. Yevgeny explains how his organization reaches Russians, inundated with propaganda from the Kremlin, by collecting stories and news articles - which otherwise would be blocked in Russia for political reasons, like the website Meduza - translating them in to Russian where applicable, and by using unique technological tricks to share this banned content through easy-to-share SOS-Link™ links. Yevgeny explains how his team sidesteps Russia's draconian content censorship to share the hidden truth with Russians blinded by years of government propaganda. Show notes: https://samizdatonline.org/ (Samizdat Online); "https://www.thebulwark.com/why-ukraine-is-dangerous-to-putin/ (Why Ukraine Is Dangerous to Putin)" by Yevgeny Simkin

The Money
ALP changes to the safeguard mechanism; repairing the environment from the Black Summer Fires; and Green Capitalism

The Money

Play Episode Listen Later Aug 18, 2022


The Albanese Government has released a discussion paper outlining changes to the safeguard mechanism ensuring high industrial polluters decarbonise to levels set. Hugh Grossman from RepuTex Energy explains what this means. Meanwhile the University of Queensland in conjunction with the WWF-Australia have put a dollar figure on how much funding is needed to repair the damage to habitat caused by the Black Summer Fires.  Dr Michelle Ward breaks down the numbers. And green capitalism. Adrienne Buller discusses why acting on climate change through the prism of capital markets does not work in her book, The Value of a Whale. 

Keep It A C Note Podcast
Racism Is A Control Mechanism

Keep It A C Note Podcast

Play Episode Listen Later Aug 17, 2022 54:17


On Episode 82 Brown, Jon & Vito Discuss & Debate Donald Trump Raid, Tom Brady M.I.A, Top 5 Current Coaches In The NFL, Young Thug New Rico Charges, Philadelphia District Attorney Press Conference Addressing Gangs In Philadelphia, Rayful Edmonds, Lebron James, Lack Of Support For WNBA, Top 3 Current Players In The Pacific Division, Racism Being A Control Mechanism, Conspiracy Corner, Pick 1 Clip, Say It wit Ya Chest & More.....Facebook https://www.facebook.com/keepita.cnote.9Instagram; https://instagram.com/keepitacnotepodcast?utmTwitter; https://twitter.com/keepitacnotepod?s=21Youtube; https://youtube.com/channel/UCatXUVjOP4jrT0UKW2xngCw

CrossPolitic Studios
Psychology of receiving the world as a Symphony or Mechanism and the effect on our humanity [Choc Knox Unplugged]

CrossPolitic Studios

Play Episode Listen Later Aug 17, 2022 62:37


Choc Knox Unplugged
Psychology of receiving the world as a Symphony or Mechanism and the effect on our humanity

Choc Knox Unplugged

Play Episode Listen Later Aug 17, 2022 62:37


Fight Laugh Feast USA
Psychology of receiving the world as a Symphony or Mechanism and the effect on our humanity [Choc Knox Unplugged]

Fight Laugh Feast USA

Play Episode Listen Later Aug 17, 2022 62:37


Research To Practice | Oncology Videos
Gynecologic Cancers | Oncology Today with Dr Neil Love: Advances in Gynecologic Cancers from the 2022 ASCO Annual Meeting

Research To Practice | Oncology Videos

Play Episode Listen Later Aug 16, 2022 45:38


Featuring an interview with Dr Brian Slomovitz, including the following topics: Comparative efficacy and safety of commercially available PARP inhibitors for ovarian cancer (OC) (0:00) Patient- and disease-specific considerations in the selection and sequencing of treatment for OC with BRCA mutations (11:39) Mechanism of action of mirvetuximab soravtansine; recent efficacy and safety data with mirvetuximab for platinum-resistant OC from the SORAYA trial (15:13) Potential integration of mirvetuximab soravtansine into the treatment algorithm for platinum-resistant OC; emerging data with niraparib/dostarlimab and adavosertib for OC (20:23) Ongoing clinical trials evaluating tumor treating fields and upifitamab rilsodotin for OC (24:57) Recent follow-up data with pembrolizumab/bevacizumab/chemotherapy for metastatic cervical cancer (CC) from the KEYNOTE-826 trial (27:30) Efficacy and safety data with lenvatinib/pembrolizumab from the KEYNOTE-775 trial for endometrial cancer (EC); benefit of lenvatinib/pembrolizumab in subsequent lines of therapy (32:13) Updated data with dostarlimab for microsatellite instability (MSI)-high EC; ongoing clinical trials evaluating immunotherapy versus chemotherapy alone for MSI-high EC (35:47) HER2-low data with T-DXd for breast cancer and its potential role in therapy for EC; emerging role of mTOR inhibitors; ongoing investigations and unmet needs in OC, CC and EC (40:01) CME information and select publications

Management Blueprint
106: Make the Mechanism Message with Jim Padilla

Management Blueprint

Play Episode Listen Later Aug 16, 2022 25:23


Jim Padilla is the founder and CEO of Gain the Edge, a sales service firm that provides business owners with top-notch sales teams, live events, and hands-free sales processes and systems. We talk about the Rainmaker Sales System, the role of emotions in buying decisions, and how to improve your control over the sales process.   Timestamps  [00:58] Jim's entrepreneurial journey [02:14] The difference between selling during and after a launch [03:16] How to improve your control over the sales process  [04:29] What is the Rainmaker Sales System? [07:52] Why the Rainmaker system works in all industries  [09:41] The role of emotions in buying decisions  [11:03] How to make the mechanism the message in sales [13:34] Why you need to sell according to how your clients buy [17:17] Things that stunt your ability to scale [21:52] How to scale your business [23:42] Parting thoughts      Links and Resources Steve and Greg Cleary's Book: Pinnacle: Five Principles that Take Your Business to the Top of the Mountain Jim's LinkedIn Jim's Website  

Liona Hotta’s Podcast
Self Trust & People Pleasing Mechanism

Liona Hotta’s Podcast

Play Episode Listen Later Aug 14, 2022 5:10


Our people pleasing mechanism comes from our historical learning that by making others happy we are being loved, appreciated and cared for, as opposed to being loved for who we are, for simply existing in our uniqueness.

Oncotarget
Press Release: Novel Regulatory Mechanism of GLI3 by Toll-like Receptor Signaling

Oncotarget

Play Episode Listen Later Aug 9, 2022 4:35


A new research paper was published in Oncotarget on August 3, 2022, entitled, “A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling.” The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little is known about SMO-independent regulation of GLI3. “Hedgehog (HH) signaling is well known for its role in embryonic development, cancer and inflammation [1–4]. At the center of HH signaling are the 2 receptors patched (PTCH1) and smoothened (SMO) along with GLI transcription factors [5]. In the absence of HH ligand, PTCH1 inhibits SMO.” In this study, researchers (Stephan J. Matissek, Mona Karbalivand, Weiguo Han, Ava Boutilier, Estefania Yzar-Garcia, Laura L. Kehoe, Devin Storm Gardner, Adam Hage, Krista Fleck, Vicki Jeffers, Ricardo Rajsbaum, and Sherine F. Elsawa) from the University of New Hampshire and University of Texas Medical Branch identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression. The researchers showed that GLI3 expression is induced by LPS/TLR4 in human monocyte cell lines and peripheral blood CD14+ cells. Further analysis identified TRIF, but not MyD88, signaling as the adapter used by TLR4 to regulate GLI3. Using pharmacological and genetic tools, they identified IRF3 as the transcription factor regulating GLI3 downstream of TRIF. “Furthermore, using additional TLR ligands that signal through TRIF such as the TLR4 ligand, MPLA and the TLR3 ligand, Poly(I:C), we confirm the role of TRIF-IRF3 in the regulation of GLI3.” They found that IRF3 directly binds to the GLI3 promoter region and this binding was increased upon stimulation of TRIF-IRF3 with Poly(I:C). Using Irf3−/− MEFs, the researchers found that Poly(I:C) stimulation no longer induced GLI3 expression. Finally, using macrophages from mice lacking Gli3 expression in myeloid cells (M-Gli3−/−), they found that in the absence of Gli3, LPS stimulated macrophages secrete less CCL2 and TNF-α compared with macrophages from wild-type (WT) mice. “Taken together, these results identify a novel TLR-TRIF-IRF3 pathway that regulates the expression of GLI3 that regulates inflammatory cytokines and expands our understanding of the non-canonical signaling pathways involved in the regulation of GLI transcription factors.” DOI: https://doi.org/10.18632/oncotarget.28261 Correspondence to: Sherine F. Elsawa – Email: sherine.elsawa@unh.edu Keywords: GLI3, inflammation, TLR About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com. Oncotarget Journal Office 6666 East Quaker Str., Suite 1A Orchard Park, NY 14127 Phone: 1-800-922-0957 (option 2)

The Nonlinear Library
AF - Announcing: Mechanism Design for AI Safety - Reading Group by Rubi

The Nonlinear Library

Play Episode Listen Later Aug 9, 2022 7:17


Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Announcing: Mechanism Design for AI Safety - Reading Group, published by Rubi on August 9, 2022 on The AI Alignment Forum. We're starting a new reading group for people interested in applying mechanism design tools to technical AI alignment. If you're interested in joining, you can apply here by August 22nd (applying takes less than five minutes). If you have recommendations for papers to discuss, please mention them in the comments. What We're Doing Mechanism design is the study of how to reach desirable outcomes or equilibria in the face of differing incentives and incomplete information. Many AI safety researchers have expressed enthusiasm about the potential of using these tools for work in alignment, but relatively little work has been done in the intersection. We believe this is partially due to a lack of potential researchers with expertise in both technical AI safety and mechanism design, and partially due to a lack of shovel-ready problems. The goal of this reading group is to make progress on both fronts. There are three main areas that this reading group will cover: Work at the intersection of technical AI safety and mechanism design, and where it can be expanded Current work in technical AI safety, and how mechanism design tools can help Current work on mechanism design, and how it can be applied to technical AI safety The plan is to start with papers in the intersection, then alternate between papers on technical AI safety and papers on mechanism design while keeping the broader perspective in mind. Note that although we believe AI governance work is important and contains many applications for mechanism design, that will not be the focus of this reading group. Who We Are and Who We Want I (Rubi) am entering the 2nd year of a PhD in Economics this fall, and am currently working on technical AI safety in Berkeley through the SERI MATS program. Other likely participants include three Economics PhD students at top schools and a Math undergraduate student currently taking part in the SERI Summer Research Fellowship. Our hope for this reading group is to connect with people who have similar interests and create the potential for future collaborations. Based on current expressions of interest, we expect the modal participant in the reading group to be a PhD student in economics, focusing on economic theory, who has read through the AGI Safety Fundamentals curriculum (or an equivalent, such as Eleuther's). If that sounds like you, definitely apply! However, these should not be considered necessary qualifications. Talented undergraduates with an interest in both areas or experts in one area who would like to learn more about the other should also apply. If you're unsure whether you have the background necessary to keep up with this reading group, a good test is to try skimming The Off-Switch Game. It's a short paper, and on the more accessible end of papers we will be discussing. If you understand it or predict you would be able to understand it within an hour, then you are likely to be able to process the papers that we will discuss without too much additional work. If you find yourself struggling to understand the mathematical notation and proofs, then that is likely a bottleneck and you should consider prioritizing work to advance your comfort level there. Participants will be expected to commit approximately eight hours a week for this reading group, which consists of five to seven hours reading the week's paper and an hour and a half to discuss it. If it becomes apparent that a participant is repeatedly not reading or only skimming the papers, they will be removed from the reading group. Please ensure that you can dedicate the required time before applying. Logistics The application form can be found here. The only mandatory fields are a link/upload of your...

Debunking Economics - the podcast
Can the price mechanism fix everything?

Debunking Economics - the podcast

Play Episode Listen Later Aug 8, 2022 33:31


On the Why Curve podcast last week, Phil (and Roger Hearing) spoke to Daniel Gros, Director of the Centre for European Policy Studies, who argued that the gas crisis in Europe will be largely resolved by the pricing mechanism. High gas prices from Russia are making LNG imports feasible, because Europe will pay more than Asia for supplies. It won't completely bridge the shortfall, he says, but if Europeans make a 15 percent cut in usage, then there will be no need to negotiate with Putin. This week on the Debunking Economics podcast Steve Keen argues that the pricing mechanism ignores the needs of the poor and has, for decades, favoured the rich. The fact that governments need to subsidise low-income households against rising fuel prices, whilst energy companies report record profits, demonstrates just how broken the pricing mechanism is. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Speaking Of Reliability: Friends Discussing Reliability Engineering Topics | Warranty | Plant Maintenance

Reliability data analysis is rarely - by itself - enough. Why? Well, if we are trying to challenge a preconceived idea about something, then we need to respect that it is a human being we are trying to convince. So what can we do? The post SOR 781 Data and Mechanism appeared first on Accendo Reliability.

Two Minutes in Trade
Two Minutes in Trade - Rapid Response Mechanism

Two Minutes in Trade

Play Episode Listen Later Aug 8, 2022 3:39


USMCA companies actively working for labor legitimization at facilities in Mexico but complaints of worker right violations keep being raised. Listen for more on today's Two Minutes In Trade.

Oncotarget
Does a Mechanism Linking Cellular Aging to Cellular Quiescence Exist?

Oncotarget

Play Episode Listen Later Aug 8, 2022 10:58


Listen to a blog summary of a trending research paper published by Oncotarget on July 28, 2022, entitled, "Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast." ______________________________________ The mechanisms of cellular aging and cellular quiescence have been preserved throughout evolution. Cellular quiescence is a temporary state of cell cycle arrest and low metabolic activity. Importantly, quiescent (Q) cells maintain the ability to quickly activate and re-enter the cell cycle (in response to the appropriate stimuli). Recent research has shown that cellular quiescence may play a role in cellular aging. In a 2020 study, research findings indicated that the rate at which yeast cells age is determined by a complicated program that affects 1) when a state of quiescence is entered, 2) how long quiescence is maintained and 3) when the cell exits quiescence. Researchers found that caloric restriction (CR) (a geroprotective intervention) appears to remodel this program, and this remodeling could be responsible for the CR-dependent delay of yeast chronological aging. Thus, the researchers considered the question: Does a single mechanism exist which links cellular aging to cellular quiescence? “We have introduced a new yeast model for studying mechanisms linking cellular aging to cellular quiescence [109, 110].” In a new study, researchers (Anna Leonov, Rachel Feldman, Amanda Piano, Anthony Arlia-Ciommo, Jennifer Anne Baratang Junio, Emmanuel Orfanos, Tala Tafakori, Vicky Lutchman, Karamat Mohammad, Sarah Elsaser, Sandra Orfali, Harshvardhan Rajen, and Vladimir I. Titorenko) from Concordia University, Montreal, used a new yeast model to test their hypothesis that a mechanism exists linking cellular aging to cellular quiescence. On July 28, 2022, their research paper was published in Oncotarget and entitled, “Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast.” Full blog - https://www.oncotarget.org/2022/08/05/does-a-mechanism-linking-cellular-aging-to-cellular-quiescence-exist/ DOI - https://doi.org/10.18632/oncotarget.28256 Correspondence to - Vladimir I. Titorenko - vladimir.titorenko@concordia.ca Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28256 Keywords - cellular aging, cellular quiescence, longevity, gerotargets, geroprotectors About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Debunking Economics - the podcast
281. Can the price mechanism fix everything?

Debunking Economics - the podcast

Play Episode Listen Later Aug 8, 2022 33:31


On the Why Curve podcast last week, Phil (and Roger Hearing) spoke to Daniel Gros, Director of the Centre for European Policy Studies, who argued that the gas crisis in Europe will be largely resolved by the pricing mechanism. High gas prices from Russia are making LNG imports feasible, because Europe will pay more than Asia for supplies. It won't completely bridge the shortfall, he says, but if Europeans make a 15 percent cut in usage, then there will be no need to negotiate with Putin. This week on the Debunking Economics podcast Steve Keen argues that the pricing mechanism ignores the needs of the poor and has, for decades, favoured the rich. The fact that governments need to subsidise low-income households against rising fuel prices, whilst energy companies report record profits, demonstrates just how broken the pricing mechanism is. Listen to the end of this podcast for some very exciting news.

The Shoney Show
Ask Shoney - Selling The Result vs Mechanism

The Shoney Show

Play Episode Listen Later Aug 5, 2022 2:00


Most coaches are running through tar - simply because they're talking about and selling the wrong part of their programme/offer... Want your next 10+ coaching leads for free? Your Next 10+ Coaching Leads Challenge kicks off very soon... https://www.neilshoney.com/leads

Our Curious Amalgam
#179 What Have We Learned From Empirical Studies? Potential Antitrust Concerns Arising From Common Ownership

Our Curious Amalgam

Play Episode Listen Later Aug 1, 2022 34:38


There is a growing interest in understanding the “ownership interests hypothesis,” i.e., whether investors holding interests in competing firms will soften firms' incentives to compete and generate anticompetitive effects. But what do the data show? Isabel Tecu, principal at Charles River Associates and co-author of a leading study on common ownership focusing on the airlines industry, discusses her observations and insights with Anora Wang and Christina Ma. Listen to this episode to learn about the knowns and unknowns from the empirical evidence as well as implications for competition policy. With special guest: Isabel Tecu, Principal, Charles River Associates Related Links: 1. José Azar, Martin C. Schmalz & Isabel Tecu, Anticompetitive Effects of Common Ownership (Working Paper, 2014) 2. Isabel Tecu, "Anticompetitive Effects of Common Ownership" at Seven Years, Antitrust Magazine, Volume 36, Issue 1 (Fall 2021) Hosted by: Anora Wang, Arnold & Porter and Christina Ma, Wachtell, Lipton, Rosen & Katz

Show Me The Nuggets
6 Core Things That an Agency Needs Part 6 - The Conversion Mechanism

Show Me The Nuggets

Play Episode Listen Later Jul 25, 2022 10:12


In this episode, Joe will show you how he uses his preferred conversion mechanism to convert at least 50% of leads. At the end of the day, it won't matter if you can increase traffic and get in front of your target audience if you can't convert. Strategy calls or consultations are Joe's preferred conversion mechanism. Joe will walk you through the important points of making this conversion mechanism work for you.

The Veterinarian Success Podcast
#143 Paul Diaz - Non-Competes: A Mechanism for Control & Greed

The Veterinarian Success Podcast

Play Episode Listen Later Jul 24, 2022 49:24


Today I'm joined by Paul Diaz of Founder and Principal Consultant at Hire Power Consulting. Paul is a former Marine who, post service found his way into the veterinary world working for one of the largest corporations in the space and helped grow the talent pool over his time there. He started Hire Power Consulting in 2020 and is on a mission to end the non-compete in veterinary medicine. If you don't follow Paul on LinkedIn, you are missing out – his straightforward no, BS style is what caught my attention and made this a must interview. He is poking fun at the lack of consistency in the broader veterinary community for talking a good game but not following through on their promises. Paul's background, experience, and expertise. The difference between non-competes and non-solicits Retention and the idea of abundance vs. scarcity The reason the veterinary shortage can be attributed to non-competes. How Paul made the hard pivot and change in his business and the story behind his passion. The best vs. worst employment contracts in veterinary medicine. https://www.linkedin.com/in/pauldiaz123/ (Paul's LinkedIn) https://www.linkedin.com/pulse/suffer-silence-how-non-compete-damaged-veterinarian-paul-diaz/ (Suffer In Silence; How the Non-Compete Damaged a Veterinarian) https://www.change.org/p/veterinarians-end-the-veterinary-non-compete-requirement?recruiter=1252473139&recruited_by_id=3531ba20-89b5-11ec-aa9f-ebdb6fd6fabc&utm_source=share_petition&utm_campaign=share_petition&utm_medium=copylink&utm_content=cl_sharecopy_32315835_en-US%3A4 (End the Veterinary Non-Compete Requirement - Petition ) Our Sponsors https://www.veterinariansuccesspodcast.com/guardianvets (GuardianVets) (be sure if you reach out to mention us for 50% off your first month) https://www.veterinariansuccesspodcast.com/vetcheck-pet (VetCheck Pet Urgent Care Center Franchise)