Podcasts about Mechanism

H2 blockers may not receive as much attention as proton pump inhibitors, but they continue to play an important role in managing acid-related disorders. In this episode of the Real Life Pharmacology podcast, we’ll review how H2 blockers work, compare the available agents, discuss important adverse effects, renal dose adjustments, drug interactions, and identify the patients who are most likely to benefit from these medications. Whether you’re a pharmacist, nurse, pharmacy technician, physician, or student, this episode provides practical clinical pearls you can apply immediately to patient care. In this episode, I also discuss a new podcast I discovered – go check out the Mechanism of Action Podcast! It is an entertaining and educational look at how many of the medications used today were discovered and derived.

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Spike Proteins with Dr. Glenn, Beyond Cholesterol & Better Heart Testing with Dr. Dearing [0:00:00] – Intro: Brian Johnson, Longevity & Oxalates + Farmers Market Light banter about: Ed coining the term “peak span” and using it in interviews. Ed's social media success (8.3 million views in 90 days). Joking about Ed doing a shirtless video and his bodybuilding competition and carb loading. Ed talks about Brian Johnson (longevity guru who spends ~$2M/year trying to live to 120): Johnson recently announced an autoimmune condition where his stomach is “eating its own stomach.” Ed admires his data and “Blueprint” protocol but believes two key factors in Johnson's regimen contributed to this issue. Ed teases that one factor is excess oxalate-rich foods; the other factor is left as a teaser for Ed's social media video. Ed announces a weekly farmers market at Nutrition World: Every Wednesday, inside the store, morning to mid-afternoon. Run by a young family with clean farming practices and minimal chemicals. Nutrition World does not profit from it; framed as a service to the community and support for small farmers. [0:05:04] – Upcoming Guests, Ed's E‑Books & Podcasts Ed previews two interviews for this episode: Dr. Glenn – testing and managing spike proteins. Dr. Curt Dearing – discussing his new book “Beyond Cholesterol” and non-traditional views on cardiovascular risk. Ed's e‑books: Six e‑books available on theholisticnavigator.com, including: Quality sleep Oxalates and pain “Are You Sick and Tired?” (diet & overall health) Oral health Immune system “Core Four” foundational supplements Podcasts: Ed mentions his Holistic Navigator podcast Clint promotes Nooga Podcasts (noogapodcasts.com) – a network of 20+ podcasts. [0:09:26] – Interview with Dr. Glenn: What Are Spike Proteins & Why They Matter Dr. Glenn defines spike proteins: Discovered in the 1960s, normally part of viruses from nature. Our immune system usually recognizes and dissolves natural spike proteins. For COVID-era, lab-made spike proteins: They are not recognized properly by the body. They can persist and are not efficiently eliminated. Mechanism (simplified): Spike proteins interact with ACE2 receptors (“locks” on the cell door). They unlock and open the cell doors, enter the cells, and damage/destroy cells from the inside. Clint notes he never heard the term “spike protein” before COVID; Dr. Glenn explains: Previously, they weren't an issue because the body just handled them. This is the first time in history we've dealt with lab-made spike proteins at scale. Dr. Glenn stresses this is not simply vaccinated vs. unvaccinated: mRNA vaccines were designed to produce spike proteins. But unvaccinated people with bad cases of COVID can also carry very high spike levels. His personal story: Got severe COVID in Jan 2020, pre-official naming: 2 weeks very ill on couch/bed. 3 months to feel “recovered,” but that was just the start of long-term issues. Over the next 3+ years, progressive cellular damage accumulated, leading to a broad set of symptoms. Dr. Glenn's symptoms when spikes were very high: Whites of eyes turned gray, with burning eyes all day (constant eye drops). Tinnitus (ringing in ears). Cyclical rashes under armpits. Burning nerves in quads; needed leg massage devices nightly to sleep. Gout attacks (kidneys not handling uric acid well). Venous congestion in lower left leg. Severe fatigue, getting sick frequently despite doing everything “right.” Developed endocarditis (inflammation of heart and valves); resting heart rate jumped from 55–60 to 80–105. Subtle Bell's palsy–type weakness on left side of face and brain symptoms. Laboratory findings: Test: SARS‑CoV‑2 spike protein antibody test (semi-quantitative). Thresholds: 1000: likely too high, potential cell damage. 5000: “a whole other level of danger.” His highest result: 11,694 (measured around Oct 28, 2023). Progress over four tests: 11,694 → 11,087 → ~9,950 → 8,905 (as of June 30, current year). Many symptoms have significantly improved, though: Heart rate better but not back to baseline. Tinnitus persists. Spike level is still high, so work remains. Symptoms can vary dramatically from person to person: Because spikes can enter different “doors” (cells/tissues) in different bodies. One person's profile may be mostly neurological; another's cardiovascular, etc. Dr. Glenn's clinic policy: He will not work with someone on issues like hormones, gut, or cognitive problems without a spike antibody test, because: Otherwise they may be “paddling upstream” against ongoing spike-related damage. Observation: Many patients say: “My doctor says my bloodwork is fine,” yet they feel terrible. Conventional doctors rarely order spike protein antibody tests [0:23:01] – Managing High Spike Proteins: Testing, Risk & Protocol Who Should Test & How: Ed notes frequent COVID infections (he's had it six times) and that many people have unexplained symptoms. Both Ed and Dr. Glenn suggest: Spike antibody testing should be considered for anyone with mysterious chronic symptoms, regardless of age or vaccination status. Testing can be done through labs like Be Well Labs (which Nutrition World works with) or other local options. Reference values: < 0.08 means essentially no exposure to COVID. Out of ~130 tests Dr. Glenn has reviewed, only one person was

Episode 625 of the A Minute to Midnite Show. Alex Newman from Liberty Sentinel joins Tony K. There have been some very concerning developments recently that affect the ongoing freedom of us all. Important information.

At this year's Tallinn Cyber Diplomacy Summer School, one question kept coming up: how can international cyber agreements move beyond diplomatic language and translate into real action?The question is particularly timely as the United Nations Global Mechanism prepares for its upcoming meeting in New York this July, an important milestone for the permanent UN process on responsible state behaviour in cyberspace.In this episode of the Digital Government Podcast, recorded during the Summer School, Patryk Pawlak speaks with H.E. Ambassador Egriselda López, Chair of the UN Global Mechanism, about what comes next for cyber diplomacy at the United Nations. Together, they discuss how implementation can become more action-oriented, why capacity building is essential for meaningful ownership, and how governments, experts, and technical communities can work together to make the mechanism effective in practice.Listen to the episode to learn why turning commitments into action matters now more than ever.

Today on Astronomy Daily: Japan's Hayabusa2 pulls off a nail-biting high-speed asteroid flyby, James Webb finds the same unexplained chemical mystery on Titan AND Pluto, a neutrino detector may have caught the universe's oldest supernova echo, a wild new theory tries to solve the black hole information paradox, we wrap up the weekend's aurora action, and we look at when NASA's New Horizons might finally cross into interstellar space.Monday, July 6, 2026 1. Hayabusa2's Flyby of Asteroid Torifune •        JAXA's Hayabusa2 spacecraft flew within ~800 metres of near-Earth asteroid (98943) Torifune on July 5, 2026, at a relative speed of about 5.25 km/s (~18,000 km/h). •        This is an extended-mission flyby, not a sample return — Hayabusa2 already delivered Ryugu samples to Earth in December 2020. •        Purpose: engineering demonstration of high-precision navigation relevant to planetary defense (asteroid deflection technology). •        Torifune is roughly 450 metres across. Next stop for Hayabusa2: rendezvous with asteroid 1998 KY26 in 2031. •        Source: JAXA/ISAS, Nikkei Asia, phys.org (July 5, 2026). 2. Mystery Molecule Found on Both Titan and Pluto •        James Webb Space Telescope data reveals an unexplained absorption feature at ~5.11 micrometres on the surfaces of Titan (Saturn's largest moon) and Pluto. •        Evidence points to a surface origin rather than atmospheric origin, based on limb-vs-disc-center comparison on Titan. •        Candidate compounds include allenes, but no confirmed identification yet. •        Pluto's absorption line is roughly three times broader than Titan's at the same central wavelength. •        Study led by Dr. Bruno Bézard's team (Paris Observatory); posted to arXiv June 11, 2026 — not yet peer-reviewed. 3. Super-Kamiokande's Hint of the Diffuse Supernova Neutrino Background •        Super-Kamiokande collaboration presented results at Neutrino 2026 (UC Irvine) after analyzing ~5,000 days of data. •        Found a statistically significant excess of events between 13.3–81.3 MeV — consistent with the long-predicted Diffuse Supernova Neutrino Background (DSNB). •        Significance: 2.6-sigma (~99.5% confidence) — below the 5-sigma discovery threshold, so described as an 'indication,' not a confirmed detection. •        If confirmed, DSNB would offer a new way to study the cosmic history of core-collapse supernovae via neutrinos rather than light. 4. A Theoretical Fix for the Black Hole Information Paradox •        New theoretical study proposes black holes stop evaporating just before vanishing completely, leaving a stable Planck-scale remnant (~9×10⁻⁴¹ kg). •        Mechanism: a repulsive force from spacetime torsion in a 7-dimensional Einstein-Cartan model, active at extreme (Planckian) densities. •        Proposal: quantum information is preserved via long-lived 'vibrations' in the remnant's internal torsion field. •        This is a theoretical/mathematical proposal, not an observational result. Researchers: Pinčák, Pigazzini, Pudlák, Bartoš. 5. Weekend Geomagnetic Storm / Aurora Wrap-Up •        X1.1 solar flare (June 30) and associated CME triggered a G3 (strong) geomagnetic storm around July 3–4, 2026. •        Aurora borealis visible as far south as Utah, Colorado, and Nevada in the continental US. •        NOAA SWPC reports conditions easing to unsettled/G1 levels through July 6 as CME effects wane. 6. Forecasting New Horizons' Crossing Into Interstellar Space •        SwRI researchers (lead: Dr. Jonathan Gasser) combined solar wind forecasting with heliosphere models to predict New Horizons' termination shock crossing. •        Forecast window: 2029–2040, with possible multiple crossings as the heliosphere expands/contracts with the solar cycle. •        New Horizons is currently ~66 AU from the Sun. Voyager 2 crossed its termination shock at 84 AU in 2007, with a 46% solar wind speed drop. •        New Horizons would become only the third spacecraft (after Voyager 1 and 2) to cross this boundary. •        Two papers: Advances in Space Research and The Astrophysical Journal (SwRI, 2026).Become a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-the-latest-space-news--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

Portugal has asked the EU, Spain and Morocco to have extra firefighting aircraft ready in case wildfires worsen during the current heatwave. Prime Minister Luis Montenegro said the move was precautionary and that national capacity had not yet been exhausted.

After years of stalled China–EU trade talks, the two sides have launched a new Trade and Investment Consultation Mechanism, holding its first high-level meeting and, notably, issuing a joint statement, the first of its kind since 2019. So is this the beginning of a more stabilized China–EU economic framework, or the embedding of a managed trade confrontation? Host Ge Anna is joined by Liang Linlin, Director of Communication and Research of China Chamber of Commerce to the European Union; Hussein Askary, Vice-President of the Belt and Road Institute in Sweden; Dr. George Tzogopoulos, Director of EU-China Programmes and Senior Research Fellow, at European Institute of Nice.

There are two board game mechanisms you just can't escape, they're on everyone's mind, flooding the discourse. That's combat, and card draw mitigation. Everyone won't stop talking about them. So we had to weigh in too, not just with what we feel are the best examples of games that have done them best, but some other quirky takes on them too. Before we mitigate our card draws, we talk about Rolling Deep, Eureka!, dnup, and Grinivil. 03:59 - Rolling Deep 15:12 - Eureka! 16:48 - dnup 24:48 - Grinivil 40:10 - Combat mechanisms 41:07 - Kemet 45:00 - Dune 48:40 - Shogun 52:42 - Forbidden Stars 53:51 - Dead Reckoning 54:48 - Gloomhaven 55:12 - Card draw mitigation 56:09 - Dark Pact 57:19 - La Granja 58:26 - Glory to Rome 59:58 - Through the Ages: A New Story of Civilization 1:02:07 - Race for the Galaxy 1:02:57 - 7 Wonders Duel 1:06:28 - The Vale of Eternity Get added to the BGB community map at: https://boardgamebarrage.com/map Send us topic ideas at: https://boardgamebarrage.com/topics Check out our wiki at: https://boardgamebarrage.com/wiki Join the discussion at: https://boardgamebarrage.com/discord Join our Facebook group at: https://boardgamebarrage.com/facebook Get a Board Game Barrage T-shirt at: https://boardgamebarrage.com/store

Featuring a slide presentation and related discussion from Dr Rana R McKay, including the following topics: Overview of the current landscape of prostate cancer (0:00) Mechanism of action of androgen deprivation therapy (ADT) (3:51) Findings from the Phase III HERO study evaluating relugolix versus leuprolide for advanced prostate cancer (7:18) Real-world evidence regarding the use of relugolix (12:27) Adverse event profile associated with ADT (18:34) Case: A man in his early 70s with metastatic hormone-sensitive prostate cancer who receives ADT at various timepoints of treatment and is currently on relugolix (21:46) Case: A man in his early 60s with high-risk locally advanced prostate cancer who receives various androgen receptor pathway inhibitors in addition to relugolix (28:06) CME information and select publications

Disparate Impact, Merit-Based Admissions, and Federal Contracting Reforms. Guest: Michael Toth. Michael Toth discusses the historical use of "disparate impact" as a mechanism for discrimination in university admissions. He details the current administration's efforts to root out racial preferences in federal contracting. Toth argues for a return to merit-based standards to restore the principle of equal justice. 131920 SCOTUS

David Daoud and Bill Roggio analyze "pilot zones" as a mechanism to hold Lebanon's feet to the fire regarding Hezbollah's disarmament. Daoud warns that if the US prioritizes quiet with Iran, these zones could become pressure tactics against Israel rather than mechanisms for actual Lebanese performance. 8ř979 Iran

How do you safely combine locoregional and systemic therapies to treat hepatocellular carcinoma (HCC) when traditional guidelines suggest your hands are tied? In this episode of the 2026 HCC Creator Weekend™, medical oncologist Dr. Lingling Du (Ochsner Health) and interventional radiologist Dr. Beau Toskich (Mayo Clinic Florida) join Dr. Tyler Sandow to break down patient selection, timing strategies, and the practical application of clinical trial outcomes when integrating Y90 radioembolization and immunotherapy in HCC management. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Sirtex and Boston Scientific. --- Timestamps 00:00 - Introduction01:48 - Two HCC Cases03:31 - Disease Progression on Combination Therapy07:05 - Alternatives After Immunotherapy Failure09:09 - Salvage with Ablative Y9013:41 - Mechanism of Immunotherapy15:43 - EMERALD-1 and LEAP-01220:52 - Adverse Events with Combination Therapy27:21 - Treatment Timing and Sequencing28:48 - Case: Borderline BCLC B33:48 - Case: BCLC C with Portal Vein Thrombus37:06 - Raising the Survival Tail40:11 - Final Thoughts and Closing Remarks --- More about this episode The physicians highlight how selective local treatment can achieve complete responses and salvage cases with aggressive disease. They emphasize that treatment based on anatomical and biological phenotype may yield better results than strictly adhering to rigid staging categories, while acknowledging the challenges of managing microscopic disease and unpredictable long-term tumor behavior. Dr. Du and Dr. Toskich also note that selecting the right combination regimens requires balancing aggressive tumor kinetics against the patient's baseline liver function, pointing out that well-tolerated regimens like STRIDE are often easier to pair with Y90 than checkpoint or VEGFR inhibitors that alter tumor blood flow. While recent TACE-immunotherapy trials (EMERALD-1 and LEAP-012) may be confounded by patient heterogeneity, the physicians observe that a distinct subset of patients achieves durable, long-term remission, effectively raising the survival tail for an otherwise incurable population. Ultimately, they conclude that cross-specialty education and leaning into the expert intuition of a multidisciplinary team are essential for securing the best outcomes for patients with intermediate and advanced HCC. --- Resources Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma (HIMALAYA)https://clinicaltrials.gov/study/NCT03298451 A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave150)https://clinicaltrials.gov/study/NCT03434379 Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CheckMate 9DW): an open-label, randomised, phase 3 trialhttps://doi.org/10.1016/S0140-6736(25)00403-9 Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 studyhttps://doi.org/10.1016/S0140-6736(24)02551-0 Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 studyhttps://doi.org/10.1016/S0140-6736(24)02575-3 --- BackTable Vascular & Interventional (VI) is the go-to podcast for interventional radiologists, vascular surgeons, and interventional cardiologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

① China and the EU launch trade and investment consultation mechanism. What is the key focus? (00:44) ② How is the CPC's institutional system guiding the country's growth? (14:04) ③ China's outbound investment regulation will take effect on July 1. How can the country balance openness and security? (24:46) ④ How is the Middle East conflict hitting Americans' finances and travel plans? (35:10) ⑤ What is behind South Korea's massive AI and chip investment drive? (43:04)

Episode Overview With Dr. Drew Lansdown away (and reportedly playing golf in Scotland), Brian and Nirav dive deep into the sports medicine landscape of the FIFA World Cup 2026. The episode covers the unique injury patterns in soccer, what surgeons and physicians need to understand about treating elite soccer players, and the injury prevention strategies that have strong data behind them. Key Topics Covered Why Soccer Produces High Rates of Non-Contact Injuries • ACL tears are the defining non-contact injury in soccer ◦ Soccer is the #1 sport played by female athletes — a population with well-established higher ACL tear rates ◦ Quick acceleration, deceleration, and multi-directional cutting movements are intrinsic to the sport ◦ Cognitive load during play (split-second decision-making while in the air) increases landing mechanics risk ◦ Classic example: the Wayne Rooney-type ACL — trying to split a defender while thinking two steps ahead leads to a mis-step • Game structure contributes to higher injury numbers ◦ 11 players per side means more total athletes on the field ◦ Longer games (90 minutes vs. basketball or football quarters) ◦ Combined effect: more player-hours of exposure per match Load Management & the World Cup Context • The World Cup paradox: fewer games per week than top club players are used to ◦ Example: Erling Haaland at Manchester City — club season + qualifiers + Champions League stacks up to more games/week than the World Cup ◦ The bigger concern is cumulative seasonal load, not the World Cup schedule itself • The World Cup is essentially an off-season add-on for elite players ◦ Comparable to asking NBA athletes to play the NBA season and then immediately compete in the Olympics • Travel is likely less of a factor than commonly assumed ◦ Elite clubs already manage heavy international travel; accommodations are often top-tier • Early specialization a compounding factor ◦ Many World Cup players have been playing since age 10–13 with little cross-sport participation, contributing to long-term cumulative load ◦ Notable exception: Norway — athletes there tend to play multiple sports ACL Surgery Considerations for Soccer Players • Graft selection overview ◦ Bone-Patellar Tendon-Bone (BPTB): traditional gold standard — caveat is patella fracture risk with early falls onto the knee ◦ Quad Tendon: recent JBJS meta-analysis showed marginal superiority, but difference not clinically significant; less commonly used in soccer given importance of quad strength ◦ Hamstring ± Lateral Extra-Articular Tenodesis (LAT): widely used in the Premier League, largely driven by the influence of Andy Williams' work with top clubs • Return-to-play timeline ◦ Uniformly 9–12 months regardless of graft choice ◦ Phased rehab: gait & coordination → strength → agility → sport-specific • Key structural differences in elite soccer player care ◦ Academy pipeline provides high-quality early medical access — similar to minor league baseball feeder systems ◦ Bracing: elite soccer players use far fewer post-op braces and return-to-sport braces vs. American football or basketball athletes ◦ Less post-op bracing is not associated with worse outcomes in this population Hamstring Injuries in Soccer • Most common injury type in soccer globally • High-speed sprinting is the primary mechanism ◦ The hamstring functions eccentrically during the late swing phase of sprinting — peak load occurs just before foot strike ◦ The injury moment is often at the point of maximal lengthening under force • Grading and prognosis ◦ Grade 1 (mild strain): return in 1–2 weeks ◦ Grade 2 (partial tear): 3–6 weeks depending on location and extent ◦ Grade 3 (complete rupture or proximal avulsion): potentially surgical; weeks to months • Proximal hamstring avulsions deserve specific attention ◦ Complete proximal avulsions (from the ischial tuberosity) are increasingly managed operatively in athletes ◦ Strong evidence for surgical repair in high-demand athletes who want to return to competitive sport • Nordic hamstring curls: effective prevention tool (discussed later in injury prevention section) Ankle Injuries • Lateral ankle sprains are extremely common in soccer ◦ The ATF (anterior talofibular ligament) is most commonly injured ◦ Mechanism: plantar flexion + inversion, often from landing on another player's foot • The challenge of ankle turf toe and high ankle sprains ◦ Syndesmotic (high ankle) injuries are less common but significantly longer recovery — 6–10+ weeks • World Cup-specific context: artificial turf used in some venues ◦ Turf surfaces change force transmission through the ankle and may increase injury risk compared to natural grass Muscle Cramps: A World Cup Staple • Muscle cramping is ubiquitous in World Cup play — especially in heat/humidity ◦ Not a sign of poor conditioning — even elite players cramp ◦ Players accustomed to cooler climates (Northern Europe) are particularly susceptible • Mechanism: combination of dehydration, electrolyte depletion, and neuromuscular fatigue • Cramping is functionally debilitating even though it is not a structural injury • Treatment/prevention: aggressive electrolyte repletion ◦ Pickle juice: Brian and Nirav discuss — strong evidence in ultra-endurance contexts; electrolyte content is the likely mechanism ◦ Bananas, electrolyte drinks, gels — all have their place ◦ "Anything that repletes electrolytes" will help — athlete preference matters The Theatrics — Diving, Flopping & the Mystery Spray • Why do elite athletes go down so dramatically? ◦ Getting kicked in an unprotected lower extremity genuinely hurts — shin guards are getting smaller (Nirav jokes about a quarter-sized guard his daughter uses) ◦ Foul strategy: falling can draw calls or stop play — gamesmanship is real • The spray — what is it? ◦ Best evidence: a topical cooling spray similar to Icy Hot or ethyl chloride ◦ Temporarily numbs the skin and superficial nerve endings at the contusion site ◦ Not a structural fix — purely symptomatic/neurological effect on acute pain ◦ The shock of impact often wears off naturally — the spray may assist with that transition Injury Prevention — What the Data Actually Shows • FIFA 11+ Program ◦ Developed by FIFA and extensively validated in peer-reviewed literature ◦ Components: core strengthening, glute/hamstring activation, agility drills ◦ Consistent reduction in injury rates by approximately 50% ◦ How to find it: search "FIFA 11+ injury prevention" (not just "FIFA 11" — that returns the video game) ◦ Widely implemented at elite levels; underutilized in youth soccer where practice time is dominated by skill drills and scrimmaging • Nordic Hamstring Curls ◦ Strong and growing evidence for both hamstring injury prevention AND ACL injury risk reduction ◦ Works by strengthening the hamstring eccentrically — addressing the exact mechanism of hamstring strains ◦ Compliance challenge: extraordinarily difficult to perform correctly, especially in older athletes ◦ Brian and Nirav agree: nearly impossible to complete a full set, especially with added weight • Implementation gap: what gets done vs. what works ◦ Youth coaches prioritize the "fun stuff" — drills, scrimmage — over warm-up protocols ◦ 15 minutes of evidence-based warm-up is a hard sell when kids are paying for club-level coaching and want to play Clinical Pearls for Practitioners • Graft selection for soccer players is multifactorial — consider quad strength demands and fall-on-knee risk before defaulting to BPTB • Post-op bracing: the European/Premier League model of minimal bracing in elite soccer players is worth considering — less may be more in highly compliant athletes • Proximal hamstring avulsions in competitive athletes warrant surgical consultation — non-operative outcomes in this population are often unsatisfactory • Cramping ≠ poor conditioning — counseling athletes and families on this distinction is important • FIFA 11+ should be part of any soccer athlete's injury prevention conversation, especially in youth programs • Nordic curls: prescribe them, warn patients they are difficult, and set realistic expectations Quotable Moments "The World Cup paradoxically is actually fewer games per week than a lot of these players are used to." — Dr. Feeley "It's like asking NBA athletes to come in, play the NBA season, and then play in the Olympics." — Dr. Feeley on cumulative load "Our youngest now uses something the size of a quarter... that's her shin guard." — Dr. Pandya on evolving shin guard trends "Nordic curls are almost impossible. That's why you see people doing them." — Dr. Feeley "Anything that repletes electrolytes is going to be beneficial." — Dr. Feeley on cramping management Please subscribe to our podcast at Apple PodcastsCheck out our website on Simplecast

In this episode, you'll learn how to build a powerful micro brand that doesn't rely on huge follower counts or viral content, but on a sharp message, a clear sub-niche, and 1,000 true fans. The speaker breaks down the 4M Micro Brand Framework: Message, Media, Mechanism, Machine, and shows how to move from chasing random leads to consistently attracting pre-sold dream clients with a tighter brand, stronger point of view, and belief-shifting content.   "You don't need a bigger audience, you need stronger resonance."   Key Points: Micro brands win with depth, not volume 1,000 true fans can fuel a sustainable business Chasing followers ≠ getting quality buyers Stand out with a sharp, specific sub-niche Own one painful problem in your market Generic messaging attracts the wrong leads Create "dog whistle" messaging for dream clients Strong POV + story = memorable brand Use content as a belief-shifting ecosystem Workshops/masterclasses convert attention to clients Track KPIs to make growth repeatable Systems > motivation for consistent results Serve a smaller room more deeply Become the go-to expert for one clear outcome Connect with Jason Meland: Email: jason@goliveonlinemastermind.com Website: https://www.growmyvisibility.com/ Instagram: @coachjasonmeland Facebook: Jason Meland - In Demand Coach LinkedIn: Jason Meland

Dietitians Torwen Eerkens and Aidan Muir run through 7 things worth knowing about caffeine and its effects on alertness, performance, sleep and anxiety.    (00:28) - Caffeine Sources (1:41) - The Half-Life of Caffeine (2:00) - Genetic Variability in Metabolism (3:29) - Mechanism  (4:04) - Training Performance (5:30) - Sleep Impacts (6:05) - Anxiety & L-Theanine  WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en Our dietitians

What if a doctor tells you there is nothing more they can do to fix your heart blockages, and you've run out of options? In this episode of The Heart of Innovation, hosts Kym McNicholas and Interventional Cardiologist Dr. John Phillips introduce you to EECP (Enhanced External Counterpulsation)—a powerful, non-invasive "Hail Mary" technology that has been saving cardiac patients for decades but remains drastically underutilized in mainstream medicine. In this deep-dive discussion, the team is joined by world-renowned cardiologist Dr. Richard Brown (consultant for Flow Therapy and former head of Johnson & Johnson's Save Legs, Change Lives program) and Jack Clifford, a cardiovascular patient and advocate who famously refused bypass surgery and used EECP to get back to running marathons.

Reflections from host Sarah Olivieri ... Why Your Nonprofit Can't Afford to Outsource Its Own Capacity There is a moment that arrives in almost every mission-driven organization. You build something that works. A program, a platform, a process. It depends on one person, one vendor, one funder, one system that only one set of hands understands. And for a while, that works just fine. Then that one thing disappears. The developer leaves. The funder pulls out. The grant ends. The person who knew how everything fit together walks out the door. And suddenly the thing you built is not just struggling. It is locked. You cannot get in. You cannot fix it. You cannot move. This is not a story about bad luck. When an organization's capacity lives entirely outside its own walls, a single disruption becomes an existential threat. That is a question of nonprofit technology capacity, and it is structural. When the systems your mission depends on are owned by someone else, you are not running an organization. You are renting one. The Source of This Thinking I've been thinking a lot about this lately. I recently had a conversation about exactly this with Chris Conlee, and it sharpened how I think about what actually creates staying power in nonprofits. Not because the ideas were new, but because they explained why certain approaches hold up over time. Outsourced Capacity Is a Structural Vulnerability Here is the pattern I keep seeing. A heart-first leader has a real idea. They do not have the technical skill to build it, so they hire it out. They find a vendor, sign a contract, and hand over the keys. The thing gets built. It even works. What they have actually done is create a dependency they cannot see. The code, the logins, the design files, the institutional knowledge of how it all connects, all of it lives somewhere else. As long as the relationship holds, nobody notices the risk. The risk is invisible right up until the moment it is the only thing that matters. This framing adds risk because it hides the cost. You feel like you saved money by not building in-house. What you actually did was move the most fragile part of your organization outside your own control and hope nothing ever happened to it. When the disruption comes, and it always comes eventually, the bill arrives all at once. You are locked out of your own work. You have already spent more than you raised. And you are facing a choice between starting over and shutting down. Heart-First Is Not the Problem Let me say something clearly, because heart-first leaders carry too much shame about this already. The nonprofit sector is full of people who led with their hearts and figured out the systems later. Very few of them woke up one day and decided to become a nonprofit CEO and then went to school for it. They saw a need. They moved toward it. The leadership skills and the systems came second. There is nothing wrong with that order. The mission should come first. The trouble is what happens when the heart builds something real and then never circles back to build the foundation underneath it. You cannot run a complex business model on heart alone forever. At some point the moving parts multiply, the dependencies stack up, and the gap between what you care about and what you can actually control becomes the thing that breaks you. The answer is not to care less. It is to build the plumbing first, so the thing you care about has something solid to stand on. The Single Point of Failure Is Always a Design Choice When you rely on one developer, one platform, one funder, you have made a design choice, whether you meant to or not. You have decided that the survival of your organization rests on something you do not control. Most leaders never decide this consciously. It happens by default. You build the fastest way you can with the resources you have, and the fastest way almost always means leaning hard on a single source. Speed feels like progress. The hidden cost is concentration. The same logic shows up in budgets, which is why I think of underfunding as a design choice rather than an accident. The work of leadership is to look around the corner before the corner arrives. Where is your organization dangerously concentrated right now? One major donor who covers half your budget. One staff member who is the only one who knows how payroll runs. One vendor who holds the keys to the system your whole program depends on. These are the questions that separate organizations that last from organizations that get one bad season and disappear. The Mechanism, Named Plainly One line from that conversation has stayed with me: "It's not that you need to use AI to stay ahead, because it's now sort of expected. If you're not using AI, you're just by default behind." What I appreciate about this framing is that it explains the mechanism. The ground has shifted. The tools that used to require a hired specialist and a five-figure budget are now within reach of a determined leader with the right guardrails. The barrier that justified outsourcing your capacity is mostly gone. When you keep outsourcing anyway, you are paying the old price for a problem that no longer requires it. Owning Your Capacity Changes What You Can Survive When Chris rebuilt his organization's app himself, the thing that changed was not the app. It was the relationship between the organization and its own infrastructure. A user reports a bug. He opens the logs. He fixes it in minutes, in-house, without waiting on anyone twelve time zones away. That is what owning your capacity buys you. Not perfection. Things still break. Owning your capacity means that when something breaks, you can fix it. The difference between an organization that survives disruption and one that does not is rarely the size of the disruption. It is whether the organization can respond without being locked out of its own work. This is true far beyond app development. The same logic applies to your donor data, your financial systems, your program delivery, your knowledge of how the whole thing runs. Wherever a single external dependency holds your mission hostage, you have found the place that will break you first. What This Makes Possible When a leader sees this clearly, the relationship to technology stops being a source of dread. The fear of the system breaking, of the vendor disappearing, of being locked out, that fear comes from not owning the thing your mission depends on. Build the capacity inside the organization and that weight lifts. What you are left with is an organization that can absorb a bad season without collapsing. One that fixes its own problems instead of waiting on someone else to find the time. One that can take the expertise it already holds and put it in front of the people who need it, at a scale that actually moves the needle. That is what staying power looks like. It is built, not hoped for. Closing This isn't about doing more. It's about owning what your mission depends on. Nonprofits can control their own systems. They can fix their own problems. They can scale the expertise they already have. Not by hiring it all out and hoping it holds, but by building the capacity to stand on their own. About the Guest Chris Conlee is my guest for this episode. Chris is an Army veteran and a long-time Hollywood film editor who traded the red carpet for the server room to build something that matters. After a series of "perfect storm" disasters—including a total industry shutdown and losing our lead developer—I spent six months teaching myself to code with AI to rebuild PIFster from the ground up. My wife Shashana and I now run this community of micro-donors, where we prove every day that a bunch of people giving just $1 a month can collectively change the life of an "underdog" charity. When I'm not in the code, I'm likely at our home in East LA, which we've turned into a bit of a sanctuary for local street rescues. Connect with Chris: Website: ChrisConlee.com (Personal) Website: imdb.com (Other) LinkedIn: linkedin.com/in/chris-conlee-editor Be sure to subscribe to Inspired Nonprofit Leadership so that you don't miss a single episode, and while you're at it, won't you take a moment to write a short review and rate our show? It would be greatly appreciated! Let us know the topics or questions you would like to hear about in a future episode. You can do that and follow us on LinkedIn.

Resources for the Community:___________________________________________________________________Linktree Our Favorite ThingsNeed help appealing your GLP-1 denials? www.FindHonestCare.com/KimRo - Telehealth for GLP1 Weight ManagementGLP-1 Stall? Why Your Body Stops Losing Weight | Dr. Michelle GordonHosts Kim Carlos and Kat Carter talk with obesity medicine specialist Dr. Michelle Gordon about the biological factors behind a GLP-1 weight loss plateau. If you are on a medication like tirzepatide or semaglutide and the scale stops moving, it is driven by a complex neuroendocrine response.Dr. Gordon explains that the hypothalamus operates like a stubborn thermostat, defending a specific weight set point. When you lose weight, the brain reads the change as a threat and triggers physiological defenses. To prevent further weight loss, the body increases hunger hormones and simultaneously lowers its energy expenditure.Key topics include:The Mechanism of a Stall: A weight plateau occurs at the exact point where your declining daily energy expenditure meets your rising natural hunger signals.Menopause and Fat Oxidation: Midlife hormonal shifts cause fat oxidation to drop, which alters metabolic burn rates and shifts fat storage to the stomach.The Chronic Disease Reality: Clinical data shows that stopping a GLP-1 medication typically results in regaining about two thirds of the lost weight, proving obesity requires continuous management.Muscle Mass Preservation: Rapid weight loss from any method causes muscle loss, making strength training essential to preserve lean muscle and protect long-term functional health.Connect to Dr. Michelle Gordon:Substack: https://drmichellegordon.substack.com/Instagram: https://www.instagram.com/doctormichellegordon/Facebook: https://www.facebook.com/drmichellegordon/Practice Website: https://drmichellegordon.com/LinkedIn: https://www.linkedin.com/in/drmichellegordon/______________________________________________________________________Join this channel to get access to perks:   / @theplussidez______________________________________________________________________#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #ObesityCare #PatientAdvocate #GLP1Community #RealGLP1StoriesSend us Fan Mail!Support the showKim Carlos, Executive Producer TikTokInstagram Kat Carter,  Producer TikTokInstagram 

Could you have metabolic dysfunction even at a normal weight?This episode challenges everything we've been taught about weight and health. Dr. Cooper reveals that up to 25% of normal-weight people have metabolic syndrome, yet they're rarely screened because doctors assume they're healthy based on appearance alone.KEY TAKEAWAYSWeight and metabolic health are not the same thing - you can be metabolically unhealthy at any sizeNormal weight people with metabolic dysfunction are often overlooked and undertreated by healthcare providersKey screening tests include fasting glucose, insulin, HbA1c, triglycerides, HDL cholesterol, blood pressure, and inflammatory markers like HSCRPMetabolic dysfunction can start in your 20s and take decades to develop into serious diseaseBoth normal weight and higher weight patients face bias - normal weight people aren't screened enough, while higher weight people have everything blamed on their weightEarly screening and treatment can prevent catastrophic health outcomes later in lifeThe liver plays a crucial role in metabolism and can become insulin resistant regardless of body weightNOTABLE QUOTE"You cannot tell anything about someone's health from their outside, what they look like or what, even what they're doing necessarily, but definitely not their body size. So you can be healthy or unhealthy at any size body, and I think that's what's overlooked quite a bit." — Dr. Emily CooperLinks & ResourcesPodcast Home: fatsciencepodcast.comCooper Center for Metabolism: coopermetabolic.comResources from Dr. Cooper: coopermetabolic.com/resourcesJoin Our Community: patreon.com/cw/FatSciencePodcastSubmit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comAppendix: Key ReferencesPrimary literature supporting this episode•       Wang et al. Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. Journal of Clinical Endocrinology & Metabolism, 2023.•       Review: Beyond BMI — Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine. Journal of Clinical Medicine, December 2025.•       Korean meta-analyses on metabolic dysfunction phenotypes and cardiometabolic risk, Cardiovascular and Metabolic Sciences Journal review, 2024.•       Frontiers in Nutrition, January 2026. Associations of metabolic heterogeneity with the progression of cardiometabolic multimorbidity.•       International Journal of Obesity, September 2025. Cardiovascular risk factors associated with metabolic health phenotypes.Mechanism references•       MASLD — metabolic dysfunction-associated steatotic liver disease — nomenclature and clinical framework. AASLD/EASL consensus, 2023.•       Insulin signaling, adipose tissue dysfunction, and ectopic fat deposition — reviews on the upstream-downstream relationship.•       Epicardial adipose tissue and cardiovascular dysfunction — Frontiers in Cardiovascular Medicine, January 2026.Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.

[Content Warning]: Discussion of childhood sexual abuse, sexual assault in a carceral setting, and graphic statistics related to child sexual abuse material and human trafficking. What if the very thing you've been hiding is the thing that could set you free? Sonny Von Cleveland is an author, speaker, and survivor who spent most of his childhood enduring sexual abuse by multiple perpetrators, beginning before he could form reliable memories of it. At 16, facing the compounded wreckage of an unprotected childhood, he entered the prison system and spent 18 years inside. Today he has recently been appointed as Director of Public Engagement and Content with Our Rescue and works alongside Operation Light Shine to fight child sexual exploitation and trafficking at the source. In this conversation with Jan Broberg, Sonny introduces a framework he calls comparative trauma syndrome, the damaging habit of ranking our pain against someone else's, and based on that, deciding we're not worthy of healing. He and Jan explore why speaking about trauma isn't re-traumatizing but strengthening, why voice is the one healing tool no one can take from you, and what it actually means to interrupt your own trauma cycle. They also go deep on Operation Light Shine's intercept task forces, the staggering gap in government funding for child exploitation prevention, and what every parent and every social media user can do right now to protect children.Where To Find Sonny: Buy Sonny's book: Hey White Boy: Conversations of Redemption Conversations of Redemption on Youtube Our Rescue Mentioned Resources: Man's Search for Meaning by Victor Frankl Operation Light Shine Hunting Warhead If you or someone you know is experiencing emotional distress or suicidal ideation, please access the resources below:National Suicide and Crisis Lifeline: Call/Text 988National Sexual Assault Hotline  (RAINN) : 1-800-656-HOPE (4673)National Alliance for Mental Illness: 1-800-950-6264  

In this podcast episode, MRS Bulletin's Laura Leay interviews Gideon Segev from Tel Aviv University in Israel and Lawrence Berkeley National Laboratory and Shane Ardo from the University of California, Irvine about their ratchet-based ion pumps (RBIPs). Consisting of a nanoporous capacitor-like structure, the RBIP drives a flux of charged particles at voltages as low as 50 mV, while redox reactions need at least 1.23 V. Furthermore, the ratchet is selective where ions can be sorted based on their diffusion coefficient. This opens doors for efficient devices for desalination and selective ion separation. This work was published in a recent issue of Nature Materials. 

Hamilton voted down a data center last week. Hundreds showed up to a planning tribunal, the city council meeting was livestreamed on Reddit, and the proposal was denied. It was a real win.The infrastructure that needed the data center is unaffected.This episode is about that — and about the week Gavin realized he'd been reading off a teleprompter and feeding analytics into AI to optimize his show about how systems optimize people. The vote and the teleprompter are the same mechanism: it feels like resistance, it feels like you're doing something, and the underlying system continues exactly as designed.Not an AI apology video. Not a call-out of the people fighting data centers. Just a loop one person found himself in, and what it looked like from the inside.Equal parts Hamilton local politics, Byung-Chul Han's psychopolitics, and genuine self-incrimination.Welcome to the Collapse.

Send us Fan MailEpisode 108 of 'The Open Forum' where Religious or Non-Religious are invited to join the discussion. Guests will be invited on a first come first serve basis. Please note we can only have a maximum of 10 panelists (including efdawah panelists) at any one time.Link to join the panel: TEARS OF GAZA Donation Link: https://givebrite.com/gazacrisis© 2026 EFDawah All Rights ReservedDonate to Ijaz's medical expenses: https://buymeacoffee.com/ijazthetriniWebsite : https://efdawah.com/https://www.patreon.com/EFDawahhttps://gofund.me/7cb27d17https://www.paypal.me/EFDawahhttps://www.facebook.com/efdawah/Timestamps:00:00 - Intro01:05 - EF Dawah Panel join: Format of the Stream02:50 - Evaluation of the Modern Dawah Scene 05:21 - Advice about giving Dawah08:55 - Reminder to Muslims about Intention12:45 - Dealing with Islamophobes vs Non-Muslims 19:13 - Message to Muslims about Dawah 22:55 - Nonoah (Theist) joins: shares his beliefs24:12 - Obstacles to fully accepting Islam27:38 - Exploring the Unreliability of the Bible38:08 - Examining the beliefs of Nonoah46:40 - Inconsistencies in Nonoah's beliefs52:33 - Uplift (Ex-Muslim) joins: shares his views54:16 - Advice for dealing with faith struggles59:10 - Recognising the Signs of Allah ﷻ 1:02:26 - Understanding the Prophet's character1:05:48 - Importance of Gratitude in Islam1:08:32 - The Prophet's character: free will or destiny 1:16:02 - Free Will vs Predestination in Islam1:18:47 - Kaum (Muslim) joins1:20:46 - Responding to Christian Apologetics 1:22:36 - Refuting claims about the end of times 1:27:16 - Issues with the claims of Islamophobes1:29:12 - Exposing the Hypocrisy of Christians1:34:04 - Age of Marriage in the Abrahamic religions1:39:38 - Problems with the Far Right movements1:46:24 - Uncovering the Corruption in the UK1:49:47 - Insights into the Unreliability of the Bible2:00:10 - Analysing the Bible's errors & corruption2:07:08 - Inconsistencies in Christian theology2:08:52 - Message to Christians2:15:38 - Praying after taking ADHD medication 2:22:36 - Roy (Christian) joins2:23:01 - Arguments for the Bible's reliability 2:26:03 - Debunking Roy's arguments for the Bible 2:35:40 - Debate on the authenticity of the Bible2:54:27 - Who was Jesus pbuh sent for?3:03:11 - 1000 H (Christian) joins3:04:26 - Claim about the Qur'an's preservation3:06:35 - Establishing the Qur'an's preservation3:10:52 - Mechanism of the Qur'an's preservation3:14:56 - Dawah to 1000 H: The Message of Islam3:22:17 - Refutation of the claim of Jesus' divinity3:25:15 - Message to the Viewers3:31:27 - Closing Remarks & Wrapping UpSupport the show

reference: Sri Aurobindo and the Mother, The Psychic Being — Soul: Its Nature, Mission and Evolution, Section 3 Growth and Development of the Psychic, pp. 79-80This episode is also available as a blog post at https://sriaurobindostudies.wordpress.com/2026/06/03/the-psychic-being-and-the-mechanism-of-choosing-its-next-birth/Video presentations, interviews and podcast episodes are allavailable on the YouTube Channel https://www.youtube.com/@santoshkrinsky871More information about Sri Aurobindo can be found at www.aurobindo.net  The US editions and links to e-book editions of SriAurobindo's writings can be found at Lotus Press www.lotuspress.com#Sri Aurobindo #The Mother #yoga #integral yoga #spirituality #soul #psychic being #rebirth #Dalai Lama

Is American democracy broken, or is it just rigged? In this episode of VarmBlog, we sit down with Travis Misurell, founder of the Think: The Future is Now Coalition (Fink), to discuss a radical new framework for political engagement: moving beyond the traditional left-vs-right binary to an "Up vs. Down" perspective.We dive deep into the Digital Politics Hub (DP Hub), a materialist infrastructure project designed to bypass party gatekeepers and empower the common voter. Misurell explains how current systems manipulate our choices before we even reach the ballot and shares his vision for a citizen-owned democracy powered by transparent, digital infrastructure.Inside This Episode:The Up-Serving vs. Down-Serving Conflict: Why most politicians serve big donors and "power-boosters" rather than the grassroots.The Civic Tag Revolution: How candidates can define themselves in their own words—focusing on advocacy and identity rather than rigid party platforms.The Failure of Civic Tech: Why previous platforms failed (and why a "people-first" movement is the only way forward).AI & Open-Ended Data: How Fink uses AI to aggregate thousands of citizen priorities without the framing biases of traditional polling.The Nevada Pilot: Why Nevada was chosen as the testing ground for this new model of election reform.Digital Democracy Phase 2: A look at the future "toolbox" of citizen-owned technology, from tracking insider trading to creating a national "democracy score" for every candidate.Connect with the Movement:Ready to reclaim your vote? Join the coalition and help build a level playing field for every candidate.Visit the Hub: hub.futureis.orgTake Action: Add your name and share your community's top priorities to help drive the data that candidates need to see.Send us Fan Mail Musis by Bitterlake, Used with Permission, all rights to BitterlakeSupport the showCrew:Host: C. Derick VarnIntro and Outro Music by Bitter Lake.Intro Video Design: Jason MylesArt Design: Corn and C. Derick VarnLinks and Social Media:twitter: @varnvlogblue sky: @varnvlog.bsky.socialYou can find the additional streams on YoutubeCurrent Patreon at the Sponsor Tier: Jordan Sheldon, Mark J. Matthews, Lindsay Kimbrough, RedWolf, DRV, Kenneth McKee, JY Chan, Matthew Monahan, Parzival, Adriel Mixon, Buddy Roark, Daniel Petrovic,Julian, Drea, Free Beer 

Why do anomalous experiences so often arrive in the wake of trauma? And what happens when the people who understand that connection decide to use it as a weapon? This episode of Inquiry follows trauma as the hidden throughline connecting UFOs, consciousness, psychological operations, and the engineering of belief at scale. Kelly Chase starts with how human perception actually works, drawing on Donald Hoffman's "The Case Against Reality," James Madden's umwelt and über-umwelt from "Unidentified Flying Hyperobject," and Jeffrey Kripal's Filter Thesis, then grounds it all in the predictive processing model of the brain and Karl Friston's free energy principle. The picture that emerges is unsettling: trauma doesn't only wound a person, it makes them porous, loosening the filters that hold consensus reality in place. From there the conversation turns toward how that vulnerability has been exploited. It traces belief manipulation from the 1980 "From PSYOP to MindWar" paper by Michael Aquino and Paul Vallely, through MKULTRA and Operation Mockingbird, to the declassified reality of Operation Northwoods and the manufacturing of consent. It brings in Jacques Vallée's control system hypothesis and Colm Kelleher's concept of bidirectional mimicry to ask whether human institutions and the phenomenon itself may be using the same lever: disruption, destabilization, and the reshaping of belief in the rupture's aftermath. Then it turns the dread on its head. Research on openness to experience and Post-Traumatic Growth suggests the architects of mass stress made a critical miscalculation. Trauma creates openings, and openings go both ways. You can crack the shell of consensus reality to make people malleable, but you cannot control what hatches. Topics explored: Trauma and anomalous experience | experiencer patterns | the Filter Thesis | Donald Hoffman | perception as interface | umwelt and über-umwelt | James Madden | Jeffrey Kripal | predictive processing | Karl Friston | free energy principle | belief malleability | shattered assumptions | meaning violation | belief engineering | MindWar | Michael Aquino | Paul Vallely | psychological operations | MKULTRA | Operation Mockingbird | cognitive sovereignty | bidirectional mimicry | Colm Kelleher | black triangle craft | Jacques Vallée | control system hypothesis | Operation Northwoods | manufactured consent | openness to experience | Post-Traumatic Growth | consciousness-level immune response | non-human intelligence | contact experiences Inquiry with Kelly Chase is brought to you by SpectreVision Radio.Produced in partnership with Voltage.fm.  Referenced In This Episode The Case Against Reality: Why Evolution Hid the Truth from Our Eyes — Donald Hoffman (2019) Unidentified Flying Hyperobject: UFOs, Philosophy, and the End of the World — James Madden (2023) How to Think Impossibly: About Souls, UFOs, Time, Belief, and Everything Else — Jeffrey J. Kripal (2024) The Flip: Epiphanies of Mind and the Future of Knowledge — Jeffrey J. Kripal (2019) "The Free-Energy Principle: A Unified Brain Theory?" — Karl Friston (2010) "Trauma or Drama: A Predictive Processing Perspective on the Continuum of Stress" — Valery Krupnik (2020) "Predictive Processing and the Varieties of Psychological Trauma" — Sam Wilkinson, Guy Dodgson & Kevin Meares (2017) "Assumptive Worlds and the Stress of Traumatic Events" — Ronnie Janoff-Bulman (1989) Shattered Assumptions: Towards a New Psychology of Trauma — Ronnie Janoff-Bulman (1992) "PTSD as Meaning Violation: Testing a Cognitive Worldview Perspective" — Crystal L. Park, Mary Alice Mills & Donald Edmondson (2012) "Making Sense of the Meaning Literature: An Integrative Review of Meaning Making and Its Effects on Adjustment to Stressful Life Events" — Crystal L. Park (2010) From PSYOP to MindWar: The Psychology of Victory — Paul E. Vallely & Michael Aquino (1980) MindWar: The New Battle for the Mind — Michael Aquino (2016) Project MKULTRA, the CIA's Program of Research in Behavioral Modification — U.S. Senate Select Committee on Intelligence (1977) MKULTRA Collection — CIA Reading Room Intelligence Activities and the Rights of Americans, Book II (Church Committee Report) — U.S. Senate (1976) Justification for US Military Intervention in Cuba (Operation Northwoods) — Joint Chiefs of Staff (1962) "The Anxious State: Stress, Polarization, and Elections in America" — The Conversation (2025) "Politics Is Taking a Toll on People's Well-Being" — Psychology Today (2025) "Stressful Life Events and Openness to Experience: Relevance to Depression" — Chiappelli et al. (2021) "The Social Psychology of Responses to Trauma: Social Identity Pathways Associated with Divergent Traumatic Responses" — Orla Muldoon et al. (2019) "Posttraumatic Growth: Conceptual Foundations and Empirical Evidence" — Richard Tedeschi & Lawrence Calhoun (2004) "The Post-Traumatic Growth Approach to Psychological Trauma" — Richard Tedeschi (2023) "Confidence in U.S. Institutions Down; Average at New Low" — Gallup (2022) 2025 Edelman Trust Barometer — Edelman (2025) Support The Show Patreon: inquirywithkellychase.com Substack: inquirywithkellychase.substack.com Connect with Kelly Website: kellychase.media X: @kellychasemedia Instagram: @kellychasemedia TIMESTAMPS 04:12 Trauma and The Anomalous 07:01 Perception Is an Interface 11:05 Umwelt and Uber Umwelt 14:05 Kripal and Filter Thesis 18:27 Predictive Brain and Trauma 23:11 Belief Becomes Malleable 28:08 MindWar Doctrine 32:36 MKUltra and Mockingbird 36:58 Mimicry and Control System 42:17 False Flags and Consent 46:09 Algorithms as Trauma Engine 49:23 Openness and Growth 55:59 Consciousness Immune Response 57:18 Closing and Next Steps Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of Data in Biotech, host Ross Katz sits down with Arvind Rao, Professor of Computational Medicine and Bioinformatics at the University of Michigan, for a discussion on the gap between what biomedical AI can do and what it can reliably be trusted to do in clinical practice. Arvind's research sits at the intersection of computational oncology and AI governance and his lab works across H&E histopathology, multiplex immunofluorescence, spatial transcriptomics, and single-cell RNA sequencing, not just to build predictive models, but to understand the full lifecycle from data to model to inference, and to ask where that lifecycle can be trusted and where it can't.  The conversation moves through two of his recent papers on SPIFEE, a graph-based framework that replaces scalar interaction scores in the tumor microenvironment with spatially resolved functional representations, and a multimodal framework that traces a path from stained tissue slides to nominated drug targets via morphological pattern discovery and spatial transcriptomic mapping.  What you'll learn in this episode:  >> Why the field's central failure is not algorithmic but translational and the gap between a model that performs well on a benchmark and one that can be consistently trusted in a high-stakes clinical setting  >> How SPIFEE replaces the conventional scalar edge representation of cell-cell interactions in the tumor microenvironment with spatially resolved functional edges >> How Arvind's multimodal framework moves from H&E pathology slides labeled with clinical outcomes, through morphological pattern discovery via multiple instance learning, to spatial transcriptomic mapping, to the nomination of molecular mechanisms and actionable drug targets >> Why Goodhart's Law applies directly to foundation model evaluation in biology  >> What the AI literacy gap costs when it goes unaddressed in healthcare and pharma organizations  Meet our guest: Arvind Rao is a Professor of Computational Medicine and Bioinformatics, with a joint appointment in Radiation Oncology, at the University of Michigan. His research focuses on establishing trust in biomedical AI predictions across the full data-to-decision pipeline, integrating H&E histopathology, spatial transcriptomics, multiplex immunofluorescence, and single-cell RNA sequencing to build models that are predictive, interpretable, and biologically credible. Alongside his research, Arvind develops AI literacy programs for healthcare and pharma professionals, helping clinical and procurement teams evaluate and govern AI systems with the rigor those decisions demand. Connect with Arvind Rao on LinkedIn: https://www.linkedin.com/in/arvind-rao-3301301ba/ About the host: Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/ Connect with us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode! Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn. https://www.linkedin.com/company/corrdyn/

What is the impact of adapting to maternal narcissistic abuse? This survival mechanism, which has served you powerfully to get to here, has a downside: it impacts your life in more than one way, leaving you trapped in abuse and toxicity not only with your narcissistic mother or family, but also in career, friendships and romantic relationships. In this episode I share the 3 main ways this coping strategy impacts your life even now. The good news is: once you become aware you can take the first step and transform your life for good.

On the bird's "one siman" being severed, does it make a difference which of the esophagus or the trachea is cut? It's a machloket, whether "either one" is enough or one specific one needs to be cut. The Gemara provides a mnemonic to support 5 different arguments, half of which support the one view above and the other half the other view. Plus, the order of when the simanim themselves are examined in the context of shechitah, and then the order of cutting. Also, what if one of the simanim were cut to be 50/50 cut/not cut -- does that count as the majority being cut or not at all cut? But how can anyone be certain, to that degree of precision?

Ben Dixon is the current Head of Strength, Conditioning & Rehabilitation at Millwall Football Club.  His prior experience includes roles with Watford FC, Head Performance Coach for the Chinese Olympic Committee, Head of Physical Performance for the Taiwan national football team and the English National Ballet. Topics: Ben fills us in on his post-doctorate to date and what we can expect moving forward. What is ‘match load'? What do we often overlook when it comes to match load? Ben talks about a framework to clarify the construct of match load. What is ‘density ' in practice? How accurate is the data we are getting? How do we include all this information in our rehab systems? Advice around rehabilitation for those without GPS units What do we mean by injury-specific metrics, and how might this be something that can be applied in practice moving forward? What are we missing in our current rehab RTP models in sport of recent times? Individual factors to account for the return to play process. Position demands and rolling windows. What is the post-rehabilitation phase and how can we minimise subsequent injury here? When does rehab actually stop (by definition)? One specific change Ben has made to his rehab system based on his research that other practitioners could implement tomorrow? https://www.youtube.com/watch?v=W8WqG4C79Ws References: Ben is undertaking a Professional Doctorate at the University of Central Lancashire, evaluating rehabilitation procedures in professional football.   Ben Post Doc Papers: Match load as a construct in professional football: complexities and considerations  Evaluating rehabilitation and return to play procedures in male professional football: A narrative review. Post Rehabilitation Phase' in professional football: are we optimising player support after return to play?    References mentioned: Mechanism of Injury of soft tissue injuries research paper summary  Mitchell & Gimpel, 2024- A return to performance pathway in professional Soccer Zhang et al 2025. The time course of injury risk and return to Sport in Professional football.  Chris Bramah - SMAS Dylan Harper: Assessment of Deceleration  

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In this episode Ed interviews Dr. David Shapiro-Ilan of the USDA-ARS. They discuss the work of David's lab using entomopathogenic nematodes as a form of biocontrol. Additional Resources https://www.ars.usda.gov/research/publications/publication/?seqNo115=411611   Time Stamps 00:00 Introduction to Entomopathogenic Nematodes 03:21 Life Cycle and Mechanism of Action 06:19 Host Specificity and Target Insects 09:15 Applications in Agriculture 12:04 Production and Formulation of Nematodes 14:55 Cost and Economic Considerations 17:37 Future of Entomopathogenic Nematodes 20:37 Wrap-Up and Final Thoughts 28:53 outro with logo Zaworski, E. (Host) and Shapiro-Ilan, D. (Interviewee). S5:E9 (Podcast). Nematode Allies: Exploring Entomopathogenic Nematodes. 5/27/2026. In I See Dead Plants. Crop Protection Network.   Transcript

You built your own business to escape the grind — so why does it feel exactly the same?In this episode, Alison shares the overwhelm-free framework helping wellness practitioners replace their clinic income online without burning out, burning down their practice, or sacrificing more time with their family.At 38, Alison was lying on her couch in San Diego, completely unable to move. A full day in the clinic, back-to-back yoga classes, a weekend teacher training ahead — and her two-year-old daughter looked up at her and said "Mommy, I miss you" while she was standing right there.That was the moment everything had to change.You can't grind your way out of a business model that's built to consume your body. But you can build something entirely different. Alison teaches the exact 3-layer framework — Asset, Mechanism, Mirror — that's helping her clients hit $14K/month without sending a single email in 30 days, drop their hours while crossing six figures, and sign new clients in minimal but focused work hours.No hustle. No grind. No burning down your clinic.If you're a physical therapist, yoga teacher, chiropractor, acupuncturist, massage therapist, or holistic health practitioner whose body and life have been keeping score — it's time your business did too.What you'll learn in this episode:Real client results: $14K months, six figures crossed, and new clients signed in minimal hoursThe burnout moment that forced Alison to rebuild her entire business modelWhy the traditional wellness practitioner model is broken — and it's not your faultThe 3-layer framework explained: Asset (what you build once that sells for you), Mechanism (the repeatable system that signs clients), and Mirror (how your content reflects the transformation buyers need to see)How to apply Asset, Mechanism, Mirror on social media starting this weekWhy "working harder" makes the body-as-business problem worse — and what to do insteadWho this episode is for:Licensed wellness practitioners — PTs, DPTs, yoga teachers, chiropractors, acupuncturists, massage therapists, holistic health practitioners — who are skilled at what they do but stuck in an outdated business model that's costing them their body, their family time, and their income ceiling.Resources & Next Steps:FREE LIVE TRAINING –  Replace Your In-Person Clinic Salary: Earn 100k From Home With an Online Wellness Program – June 2nd, 10am PST: https://100k-blueprint.pages.ontraport.net/work-from-homeFollow me on Instagram →  igniteyourwellnessbusinessReady to work with me? Book a consultation call on my website!→ https://igniteurwellness.com/business-coach-for-health-coaches/Jane's app: https://janesoftware.partnerlinks.io/Alison-mclean-podcastFor a free month use code: IGNITE1MO

You've been told to "let go." Let go of attachment. Let go of resistance. Let go and trust the universe. But what if letting go doesn't actually solve the deeper problem? In this episode, David Marshall breaks down the hidden Identity Mechanism behind manifestation collapse, recurring emotional cycles, subconscious self-sabotage, and why so many people lose the very things they worked so hard to create. Most manifestation teachings focus on emotional states, visualisation, or "feeling it real." But if your deeper identity structure hasn't changed, reality often corrects itself back to familiar patterns — no matter how powerful the breakthrough initially felt. This episode explores: Why manifestation breakthroughs often fade The subconscious identity "set point" controlling your reality Why emotional release alone is not enough The two deeper things you actually need to let go of Why Neville Goddard techniques often fail long term The hidden structure behind recurring relationship, money, and life patterns The difference between temporary state change and structural identity change How consciousness and belief systems shape reality If you've ever felt trapped in cycles of: manifestation success followed by collapse repeated emotional patterns financial resets relationship loops self-sabotage trying harder but getting the same results …this episode explains why. This is not another surface-level Law of Attraction conversation. It is a deeper exploration into: consciousness mechanics identity structures subconscious beliefs reality creation manifestation psychology structural transformation Free Training Download the free Belief Blueprint and Inner Trance Journey here:   Explore More YouTube Channel: https://www.youtube.com/@davidmarshallconscious RealityMap App:  https://realitymap.app/ #Manifestation #LawOfAttraction #Consciousness #NevilleGoddard #IdentityShift #SelfSabotage #RealityCreation #ConsciousCreation #BeliefSystems #LawOfAssumption

Henry Lindner walks into the cathedral of general relativity and asks why no one can hear the pipes, flowing space as reformation of Einstein's gravity, where the medium returns and the math bows down to something almost physical, almost true. We trace the long exile of substance from physics, from Newton's absolute space through the ether wars to Mach's ghost whispering in Einstein's ear that nothing real needs to exist at all. But a simplification is not an explanation, and gravity still has no mechanism, no cause, no beating heart beneath the geometry, only equations where a theory should be. This is the Keplerian step: cleaner orbits, better math, and the Darwinian question still howling unanswered in the dark.Flowing Space: https://henrylindner.net/FlowingSpace2024wide.pdfPATREON https://www.patreon.com/c/demystifysciPARADOX LOST PRE-SALE: https://buy.stripe.com/7sY7sKdoN5d29eUdYddEs0bHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-herePARADIGM DRIFThttps://demystifysci.com/paradigm-drift-show00:00 Go! 00:03:24 — Newton's Absolute Space and the Ether00:13:26 — Berkeley, Mach, and the Rejection of Physical Substance00:31:01 — Institutions, Ideology, and the Shaping of Physics00:47:31 — Einstein's 1905 Revolution: Removing the Medium00:57:33 — The Twin Paradox and Special Relativity's Loose Ends01:20:20 — GPS and the Case for a Preferred Frame01:24:46 — General Relativity and the Equivalence Principle01:29:06 — Flowing Space: A Mathematical Refinement of Gravity01:47:36 — Where's the Mechanism? What Flowing Space Can't Explain02:07:59 — Simplicity Is Not Causality02:23:47 — The Search for Mechanics in Gravitational Theory #Physics #physicspodcast, #philosophypodcast, #quantum , #quantumphysics, #quantummechanics, #generalrelativity #gravity #ether #einstein #newton #cosmology #naturalphilosophyMERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

The Mystery of the Antikythera MechanismBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

भारती हॉस्पिटलबद्दल जाणून घेण्यासाठी या वेबसाईटला भेट द्या: www.bharatihospital.com अमुक तमुक ला subscribe करण्यासाठी click करा: https://youtube.com/@amuktamuk?si=LCVcdLVB9KMPVHrkसहवेदना किंवा Empathy म्हणजे नेमकं काय? Sympathy आणि Empathy यात काय फरक आहे?एखाद्याच्या भावनांना समजून घेणं म्हणजे त्याच्यासोबत दु:खी होणं का, की त्याला आधार देणं? आपण खऱ्या अर्थाने दुसऱ्यांच्या भावना समजून घेतो की फक्त आपला दृष्टिकोन लादतो? सहवेदना व्यक्त करणे म्हणजे मोठेपणा का? नात्यांमधली Empathy कशी असावी? आजच्या जगात Empathy कमी होत चालली आहे का?या सगळ्यावर आपण डॉ. आनंद नाडकर्णी (मनोविकासतज्ज्ञ) यांच्याशी चर्चा केली आहे. In Bhavanencha Crash Course – Season 3, we discuss the emotion Empathy.What exactly is empathy? What's the difference between sympathy and empathy?Does understanding someone's emotions mean feeling sad with them, or offering them support?Do we truly understand others' feelings, or just impose our own perspective?And is empathy really fading in today's world?We've discussed all of this with Dr. Anand Nadkarni (Sr Psychiatrist).Don't miss the full episode!आणि मित्रांनो आपलं Merch घेण्यासाठी लगेच click करा! Amuktamuk.swiftindi.comDisclaimer: व्हिडिओमध्ये किंवा आमच्या कोणत्याही चॅनेलवर पॅनलिस्ट/अतिथी/होस्टद्वारे सांगण्यात आलेली कोणतीही माहिती केवळ general information साठी आहे. पॉडकास्ट दरम्यान किंवा त्यासंबंधात व्यक्त केलेली कोणतीही मते निर्माते/कंपनी/चॅनल किंवा त्यांच्या कोणत्याही कर्मचाऱ्यांची मते/अभिव्यक्ती/विचार दर्शवत नाहीत.अतिथींनी केलेली विधाने सद्भावनेने आणि चांगल्या हेतूने केलेली आहेत ती विश्वास ठेवण्याजोगी आहेत किंवा ती सत्य आणि वस्तुस्थितीनुसार सत्य मानण्याचे कारण आहे. चॅनलने सादर केलेला सध्याचा व्हिडिओ केवळ माहिती आणि मनोरंजनाच्या उद्देशाने आहे आणि चॅनल त्याची अचूकता आणि वैधता यासाठी कोणतीही जबाबदारी घेत नाही.अतिथींनी किंवा पॉडकास्ट दरम्यान व्यक्त केलेली कोणतीही माहिती किंवा विचार व्यक्ती/कास्ट/समुदाय/वंश/धर्म यांच्या भावना दुखावण्याचा किंवा कोणत्याही संस्था/राजकीय पक्ष/राजकारणी/नेत्याचा, जिवंत किंवा मृत यांचा अपमान करण्याचा हेतू नाही.. Guest: Dr. Anand Nadkarni (Sr.Psychiatrist)Host: Omkar Jadhav.Creative Producer: Shardul Kadam.Editor: Rohit Landge.Edit Assistant: Rameshwar Garkal, Priyanka Thosar.Content Manager: Sohan Mane.Social Media Manager: Sonali Gokhale.Legal Advisor: Savani Vaze.Business Development Executive: Sai Kher.About The Host Omkar Jadhav.Co-founder – Amuk Tamuk Podcast NetworkPodcast Host | Writer | Director | Actor | YouTube & Podcast ConsultantWith 8+ years in digital content, former Content & Programming Head at BhaDiPa & Vishay Khol.Directed 100+ sketches, 3 web series & non-fiction shows including Aai & Me, Jhoom, 9 to 5, Oddvata.Creative Producer – BErojgaar | Asst. Director – The Kerala StoryHost of Khuspus – a podcast on taboo and uncomfortable topics.Visiting Faculty – Ranade Institute, Pune University.Connect with us: Twitter: https://twitter.com/amuk_tamukInstagram: https://www.instagram.com/amuktamuk/Facebook: https://www.facebook.com/amuktamukpodcastsSpotify: Khuspus #AmukTamuk #marathipodcasts 00:00 - Introduction 03:49 - Positive emotions and where empathy fits 07:00 - Difference between empathy and sympathy 08:09 - Mechanism of empathy as feeling the other person's emotion 14:33 - How empathy is demonstrated through actions and not just words 15:35 - The four different response styles 17:38 - A story about JRD Tata and Sudha Murthy 23:10 - Empathy is described as a quiet, powerful force 24:50 - Empathy is about sharing in someone's joy 26:41 - Story about Abraham Lincoln 29:37 - Practical tips on how to cultivate empathy in daily life 35:30 - Empathy is 'sadhana', a dedicated practice or discipline 38:57 - Challenge of showing empathy towards people you don't like 44:50 - Empathy in our complex modern world 46:42 - The importance of "self-empathy" or self-compassion 51:37 - Connecting empathy to positive psychology

Glen McGugan, Ph.D., Director of ASM's Mechanism Discovery Unit, discusses how curiosity‑driven research—from parasite virulence to CRISPR and complex microbial systems—drives tomorrow's breakthroughs.  Ashley's Biggest Takeaways Mechanism discovery,encompasses all of the foundational basic research across the microbial sciences and is essential for all advances in microbial science. Many transformative technologies (e.g., CRISPR) originated from curiosity-driven, basic research rather than immediate practical goals. McGugan's experience as a Program Officer at NIH provided him with a broad perspective on the research pipeline, from basic science to clinical trials, and highlighted the importance of supporting early-career scientists. Developing therapeutics for parasitic diseases is particularly challenging due to complex life cycles and limited financial incentives for pharmaceutical companies; much of the progress relies on government and philanthropic funding. ASM's Mechanism Discovery Unit serves as a neutral hub to convene interdisciplinary stakeholders, foster collaboration, and advance fundamental research. Safeguarding future breakthroughs in the microbial sciences depends on the involvement of and connections between researchers, policymakers, funders and industry partners to close gaps between discovery, implementation and impact.  

EECP Therapy and Stroke Recovery: Can a Cardiac Treatment Help Grow New Blood Vessels? When I first heard about EECP therapy in the context of stroke recovery, I was skeptical. It’s a cardiac device approved in Australia for stable angina and congestive heart failure. Stroke is not on the label. So why are we talking about it on a stroke recovery podcast? Because the mechanism is fascinating. And the research, while still emerging, is pointing somewhere worth paying attention to. In this episode, I sat down with Jack Clifford, a heart disease patient who discovered EECP therapy and began exploring its potential beyond its approved indications. What started as a cardiac conversation quickly became one of the most scientifically interesting discussions I’ve had on the show. What Is EECP Therapy? EECP stands for Enhanced External Counterpulsation. The treatment involves a set of pneumatic cuffs fitted around the calves, thighs, and buttocks. These cuffs inflate and deflate in precise synchrony with the heartbeat, inflating during the heart’s resting phase (diastole) to push blood back toward the heart, and deflating just before the heart contracts. The result is an increase in blood flow and a specific type of fluid shear stress on blood vessel walls. It’s that shear stress that makes things interesting. The Biology: Arteriogenesis and Angiogenesis To understand why EECP therapy might be relevant to stroke survivors, you need to understand two terms: angiogenesis and arteriogenesis. Angiogenesis is the sprouting of entirely new capillary vessels — the body builds small blood channels where none existed before. Arteriogenesis is different: it’s the remodelling of pre-existing, dormant collateral vessels into functional bypass channels. Think of it like upgrading a dirt track into a highway. The track was always there; the body just wasn’t using it. When blood flow is obstructed, whether by a blocked coronary artery or a stroke, the body can, under the right conditions, activate these collateral pathways. The shear stress produced by EECP therapy appears to be one of the triggers that stimulate arteriogenesis. By generating repeated waves of increased blood flow, the treatment creates the mechanical signal that tells blood vessel walls to grow and remodel. This is why cardiac researchers originally developed EECP for heart patients. But it raises a legitimate scientific question: could the same mechanism support blood flow recovery in the brain after stroke? What Does the Research Say? A 2026 meta-analysis published in the QJM: An International Journal of Medicine examined 15 randomized controlled trials involving 506 participants, looking specifically at EECP’s effects on functional outcomes in stroke patients. The results showed statistically significant improvements, with EECP outperforming control conditions on standard functional recovery measures. This is preliminary evidence, not a settled clinical consensus. The studies are relatively small, the methodology varies across trials, and EECP remains off-label for stroke in Australia. But for a therapy with a well-understood safety profile and an existing approval framework, 15 studies and 506 participants is not nothing. It’s enough to warrant serious discussion. What I Discussed with Jack Clifford Jack came to EECP as a patient, not a researcher. His experience with heart disease led him to explore the therapy, and he’s spent considerable time understanding the evidence base and connecting with practitioners. He’s not a clinician, and neither am I, but what we can do together is examine what the research actually says, what the mechanism actually is, and what questions remain unanswered. In our conversation, we discussed: How Jack first encountered EECP therapy and what led him to investigate it further The difference between approved and off-label use, and why that distinction matters What the shear stress mechanism actually looks like in practice The existing network of EECP practitioners and how stroke survivors might access the therapy The questions both of us still have about where the research needs to go Important Disclaimers   EECP therapy is approved in Australia by the TGA for stable angina pectoris and congestive heart failure (ARTG Entry 376470). Stroke is NOT an approved indication. This article and podcast episode are not medical advice. Speak with your treating physician before pursuing any treatment. This episode is not medical advice. It is a conversation about an area of emerging research that I find scientifically credible and worth understanding. The goal is to help you ask better questions, not to tell you what treatment to pursue. Where to Learn More ecplocator.com a directory of EECP therapy providers eecpbook.com is a dedicated resource on the treatment and its evidence base recoveryafterstroke.com for stroke survivors looking for a broader community Research cited: Zhao et al. (2026). Enhanced external counterpulsation for ischaemic stroke: a systematic review and meta-analysis. QJM: An International Journal of Medicine. DOI: 10.1093/qjmed/hcag010. Therapy and Stroke Recovery: Can a Cardiac Treatment Help Grow New Blood Vessels? Bill Gasiamis sits down with Jack Clifford to explore EECP therapy, a TGA-approved cardiac treatment that may stimulate the growth of new blood vessels. Together, they examine the emerging research on angiogenesis, arteriogenesis, and whether this off-label approach holds promise for stroke survivors seeking to improve blood flow to the brain. Highlights: 00:00 Introduction – EECP Therapy06:06 Recognizing Health Issues and Seeking Help09:50 Hospital Experience and Heart Health12:12 Decisions Against Medical Advice16:28 Exploring Alternative Treatments18:06 Understanding Enhanced External Counter Pulsation (EECP)21:58 The Mechanism of EECP27:03 Personal Transformation Through EECP30:29 Lifestyle Changes and Holistic Health34:35 The Impact of Stress on Health38:30 The Journey of Writing a Book43:29 The Role of EECP in Heart Health48:21 Raising Awareness for EECP Therapy56:05 Exploring the Future of EECP Therapy Transcript: Introduction – EECP Therapy Jack Clifford (00:00)Mine was really severe. 100 % blocked in my widow maker, the left anterior descending. I’m 95 in my left coronary artery and in my right main, I am 80%. And I’m still that way today, but I can run a sub seven mile. Bill Gasiamis (00:16)Welcome to the Recovery After Stroke podcast. I am your host, Bill Gassiamus. Before we get into today’s interview, I need to share something important. The topic we’re exploring today involves a medical device called an EACP, Enhanced External Counterpulsation Machine. In Australia, EACP is registered with the Therapeutic Goods Administration for the treatment of stable angina and congestive heart failure. It is not approved for stroke. What we are discussing today is emerging off-label research, not a treatment recommendation. Everything in this episode is for informational purposes only. This is not medical advice. Please speak with your treating physician before pursuing any treatment, therapy or intervention discussed here. With that said, let’s talk about something that genuinely fascinated me when I started reading the research. Your body has the capacity to grow new blood vessels, not just small capillaries, but to remodel dormant pre-existing channels into functional bypass routes. Scientists call this arteriogenesis. There’s also angiogenesis, the sprouting of entirely new Both processes matter deeply for stroke because stroke is fundamentally a blood flow problem. Now here’s where it gets interesting. A cardiac therapy developed for heart patients, not stroke patients, trigger exactly this kind of vascular remodeling. And in 2026, a meta-analysis published in the QJM across 15 randomized controlled trials and 506 participants found that EECP produced statistically significant improvements in functional outcomes for ischemic stroke patients. Now, that’s not proof. That’s not a green light to go and get an EECP, but it is worth a serious conversation. My guest today is Jack Clifford. Jack is a heart disease patient who discovered EECP therapy while managing his own cardiac condition and who has since spent considerable time investigating its potential. beyond cardiac care. I should tell you, I was skeptical going into this conversation, but I’ve learned that skepticism without curiosity isn’t really skepticism. It’s just closed mindedness. So I read the research and then I sat down with Jack. So if you find this episode valuable, I’d love for you to grab a copy of my book, The unexpected way that a stroke became the best thing that happened at recoveryafterstroke.com/book. And if you want to support the show, you can join Patreon at patreon.com/recoveryafterstroke. And I want to thank everyone who is supporting me on Patreon, especially the people that have been around for a long time and the people who have just recently signed up. I very much appreciate it. And now here’s my conversation with Jack Clifford. Bill Gasiamis (03:19)Welcome to the podcast. Jack Clifford (03:22)Thanks, Bill. Great to be here. Bill Gasiamis (03:24)Let’s give the listeners a bit of a background understanding of why you’re on the podcast. You’re not a stroke survivor, but we have something in common as ⁓ somebody who has been unwell before myself and you in the past. Tell me a little bit about your journey to the podcast So we just kind of give people an understanding as to how it is that somebody who’s not a stroke survivor. Jack Clifford (03:34)We do. Bill Gasiamis (03:51)how we ended up chatting together? Jack Clifford (03:54)Yeah, absolutely. So the quick version here is ⁓ I was on the brink five years ago of having ⁓ unsentable emergency triple bypass surgery. And ⁓ I chose a different path, which we’ll get to. ⁓ But you you have some level of placking if you have a stroke, typically, depends on the stroke, but that’s typically the case. And in my case, I had placking in my coronary arteries. So it resulted in heart disease. Mine was really severe. 100 % blocked in my widow maker, the left anterior descending. ⁓ I’m 95 in my ⁓ left coronary artery and in my right main, I am 80%. And I’m still that way today, but I can run a sub seven mile. I can do some things that a guy that’s as blocked up as that should not theoretically be able to do. ⁓ Bill Gasiamis (04:49)All right. Tell me about life before the injury. What kind of work did you do? How did you go about life? What was generally a day like for you? Jack Clifford (04:59)Yeah. So I’m retired military guy. Um, so, you know, been in the military most of my life, um, retired about 10 years ago, a little over that. And, um, so I’ve always been a pretty fit guy. It wasn’t, you know, it wasn’t a fitness issue per se. Um, and, uh, I, I, I had kind of lost some of my self care because my wife had been going through some real significant medical issues that really required my full attention for quite a while. And because of that, really stopped taking care of myself in the ways I had in the past for about 10 years. And when we had just moved to Florida, I started trying to take care of myself again. And that’s when I discovered all these problems. Bill Gasiamis (05:44)So what does not taking care of yourself look like though? Jack Clifford (05:47)Gotta be in a couch potato and being on my computer way too much research and for ⁓ trying to help my wife get better and hold down a job at the same time and raise a family and all these other things that took the priority off of me in that sense that one should be taking care of themselves, meaning exercising, meaning eating the right foods, so on and Recognizing Health Issues and Seeking Help Bill Gasiamis (06:09)You know, caregivers tend to die before the person they’re caring for much more often. And it’s cause of that reason, right? Because time is really taken up by especially full-time caregiving with somebody’s in the house and they need caregiving. need care. The caregiver tends to neglect themselves in every way, shape and form and tends to ⁓ make it about the other person. And then the other person. Jack Clifford (06:14)I’ve seen that and heard about it. Yeah. Mm-hmm. Bill Gasiamis (06:39)seems to be doing okay, but the caregiver is struggling and doesn’t ask for help and doesn’t go and doesn’t go and get looked after. And then things tend to catch up with them and they become the ⁓ sickest person in that relationship. Jack Clifford (06:55)It’s like that whole put your oxygen mask on first on the airplane type thing, right? Like, you know, we can’t we can’t give what we don’t have to give Bill Gasiamis (07:01)Uh-huh. Yeah. So you, did you notice, did you notice the steady decline in your health? Did you kind of go, I’m not feeling right. I’m a feel a bit sluggish like 10 years down the track, or did it just creep up on you? then you got to this point. Jack Clifford (07:15)It really crept, it really crept. I, you know, like I had initially exercise induced angina, but it wasn’t much exercise that induced the angina. And then it very quickly progressed to trying to walk and getting out of breath and, know, at very basic walking speeds, just moderately paced, you know, anything anybody would do out in your neighborhood. ⁓ Bill Gasiamis (07:39)Did you know that you had an angina? Jack Clifford (07:41)I did, yeah. I didn’t have a big heart attack episode like some people have. I’m 100 % blocked. There’s no heart attack to happen, right? Because the stuff is, I’m so blocked that it’s just a pure blood flow issue. A lot of people don’t understand that that 50 % blockage is a huge risk for a heart attack because you’re gonna burst a plaque and then go from 50 % to 100 % like that. But you know about collaterals. And if you have collaterals in place, the blood’s not getting flowing this way, you’re gonna recruit some lead oval collaterals to be able to just get by with your activities of day living. But if you don’t push yourself, you don’t know that you don’t have enough blood flow to do these other things. Bill Gasiamis (08:22)Okay, so you got to the point where you were so unwell as far as the blood vessels around your heart were so unwell, they were so blocked that angina led to another escalation or something happened that got you to the point where you realized, okay, things are not good. Now, tell me what angina is exactly and what it’s like to have it. How do you experience it? Jack Clifford (08:39)Yeah. yeah, yeah. I’d love to talk about that. Bill. at its most basic, it’s a supply demand mismatch. So, you know, the blood flow that’s supplying your heart ⁓ is adequate for X, Y, or Z activities of daily living. You know, walking around the house, doing the dishes, you might have enough blood flow for that, but you don’t have enough blood flow to go run a mile or even walk potentially, you know, or Hospital Experience and Heart Health but it’s all about supply demand mismatch. And that’s about just the size of the pipes, you know, if they’re clogged up, how clogged up are they? And, know, ⁓ that’s, really it. So, and what it feels like is it’s scary because it feels like a heart attack. all like, what does a heart attack feel like? Well, there’s a thousand different sort of, ⁓ descriptions of it. ⁓ you know, radiating down your arm or nausea or something in your back, but. you know, if it’s right over your heart, it’s unmistakable. And that’s at least my presentation of angina. And I think it was a pretty typical one is, you know, I have this weird kind of deep pain. initially, when I, when I started, you know, run, trying to run and got it, I thought, ⁓ you know, I just pulled a chest muscle weirdly over my heart. You know, I’ll stop and let’s see if it goes away. I come back, you know, no, same thing. Okay. Still not better. Let’s do it again. Another couple of days later, so on and so forth. I was just kidding myself, but I didn’t know anything about the horror at that point. hadn’t had to research all this stuff and do all the deep dive. Bill Gasiamis (10:16)That’s the same crazy logic that stroke survivors put to, I’m feeling weird. I’m dizzy. I’m going to go and lie down. I’m going to rest. It’ll be better later. ⁓ I’m too busy. I’ve got to go to work. ⁓ I’ve even had stroke survivors where somebody’s telling them you maybe you’re having a stroke, you know, just tongue in cheek and they’re like, yeah, no, probably not. ⁓ it’s the same crazy logic that we say about things that are unfamiliar to us that we cannot potentially. Jack Clifford (10:25)Mm-hmm. Mm-hmm. Yeah. Yeah. Bill Gasiamis (10:46)link to something so serious because we have no knowledge, we’re ignorant, right? Jack Clifford (10:47)Yeah. Well, yeah, I think that’s really part of the key there is like most times with something as sudden as what you’re talking about or what I’m talking about in my instance, because it was pretty, pretty sudden, you know, weeks and months. ⁓ We went from being these, you know, healthy people that felt like we were on top of the world to all of a sudden not. you you didn’t have a frame for what not looked like. ⁓ Bill Gasiamis (11:14)Exactly. Yeah. That’s such an important comment. We don’t have the frame for what not healthy looks like and therefore you don’t know what you don’t know. So you don’t take any action. You just brush it off. Okay. I hear you. All right. We got to the bottom of the stupidity behind a lot of my decisions as well to avoid going to hospital for a week, et cetera, the first time. ⁓ So you end up Jack Clifford (11:24)Exactly. That’s it. Bill Gasiamis (11:43)being really unwell on this particular date. Kind of what is that day like? Explain us. Jack Clifford (11:46)Yeah. Yeah. Decisions Against Medical Advice So I got tight. I, I, I’ve been a biohacker for a while. So that’s probably the only reason I’m here talking to you because I went off the beaten path really far off the beaten path to get to the place where I know what I know and I have to share what I have to share. ⁓ because I’ve been trying to help my wife get better for some significant issues, including a really bad traumatic brain injury. And some other things and doctors didn’t have the answers for those so we had to we had to kind of biohack our way out of some things I was comfortable back. I’m saying that to say my wife got me a Chili pad for my bed because you know been trying to biohack sleep for a while and the colder environments to sleep are you know better to some degree at least in theory ⁓ and so Yeah, correct Bill Gasiamis (12:32)Chili meaning cold, not spicy. Jack Clifford (12:37)Yeah, correct. A chili pad as in the cold. So it’s a device that just, you know, cools your bed off. And so I crank that down to 55. She got it for me for Christmas. So Christmas day Eve, I’m like hopping into bed, like I’m going to sleep really well tonight, you know, and I woke up at four AM like, Oh, you know, I thought that was the big one because it felt that way. I a dead sleep woke me up with, with intense chest pain. And I knew something was going on, you but I was kidding myself. I hadn’t talked to family about it. You know, I hadn’t shared anything about what was going on with anybody. So at this point I’m like, oh my goodness, you know, and I could be dying and have not had, you know, just been an idiot the whole time. So I rushed to the hospital and I didn’t have a heart attack. I just made it so cold that I made my heart work and that supply demand mismatch was happening all night long in my sleep. Bill Gasiamis (13:15)Mm-hmm. Jack Clifford (13:31)And so it got to this, you know, a giant, creeps up, you know, it’s like, can feel it. And then if you push it, you’re like, can really feel it. Well, you know, I woke up out of a dead sleep going from not feeling it when I went to sleep to, to feeling it to the extreme when I woke up. Um, but that’s when they gave me the, uh, the, uh, nuclear stress test with a treadmill test, right in the hospital. And it was, it was really bad. They can’t quantify your blockages with that, but they can tell you that, you know, you’re You’re kind of screwed. And I was like really screwed. Like it was 47, but they said I was one of the worst I’d ever seen. ⁓ yeah. So I had all weekend to think about it, you know, cause I was a Friday, fortunately, and they could, they weren’t going to do the heart catheterization until Monday and the doc, you know, I was signing consent forms for them to do bypass surgery and it was pretty clear that the odds of it getting stented was not really good, but that’s what you hope for. Right. And most people are like, we’ll just get a step. once then in you’re fine. And ⁓ in my case, it wasn’t looking likely. And my mother had had bypass surgery five years before that. And I watched her cognition after the bypass surgery just declined to the point where she’s in memory care now. And she had gone from being this vibrant book author of multiple books and you know, she was a hypnotherapist and she’s helped a lot of people in her life, done a lot of amazing things, but ⁓ she never. she never really came out of the bypass surgery as her whole self and pretty quickly was just completely not herself at all. ⁓ So I wasn’t ready to come back. Now she’s 76. Bill Gasiamis (15:03)How old? How old’s your mom? Yeah. I know with people that are older, ⁓ heart surgery can lead to cognitive decline and there is a link there. There is a number of it’s well researched. It’s a risk. ⁓ not one that you’re probably aware of and that they talk about much, but it definitely is a thing. so, okay. You’re, you’re you go to the hospital. They realize, ⁓ the Jack Clifford (15:15)Mm-hmm. Bill Gasiamis (15:37)charts are not looking good. ⁓ They do the tests. They suggest that what they can offer you is bypass surgery. your, and you’ve got a weekend, think about it and you, and you go home, do they go, do you go home with medication and joining the medications to keep the blood flowing with anything? What do they do? Jack Clifford (15:51)Mm-hmm. Where’d you go? Yeah, such a blessing. No, no, because I was leaving against medical advice so they weren’t going to help me, right? And I actually said to the doc, said, you hey, I’m new here because I just moved a couple of months ago to Florida. And I said, can I come see you? And I didn’t have a cardiologist. I didn’t need one before this. And he says, if you live that long, just walks out. So I was on my own at that point. There was no resources of institutional medicine. I had to go find resources myself. Exploring Alternative Treatments Bill Gasiamis (16:28)Wow. Things are pretty wild in Florida. If you live that long and he walked out. Jack Clifford (16:30)Yeah. Yep. That’s exactly what we said. It’s a very sobering moment for me. Yeah. Bill Gasiamis (16:35)And you walked out. Yeah, and you walked out. Far out, man. So what’s the thinking behind walking out of that? Because I understand ⁓ that there are very few things that, like my situation was different, right? But I’ll give you kind of my thinking behind the, I’m gonna walk out routine. It’s like, there is a part of me that sort of says, I don’t need to subscribe to all that medical stuff, all the nonsense. I wanna try and avoid the medications. I wanna do all of that. Jack Clifford (16:41)Yeah. Yeah. Bill Gasiamis (17:07)That means I’ve got to do some work to get to that point, right? I’ve got to make sure that I’m eating well. I’m sleeping well. ⁓ I’m exercising. ⁓ I’m not overweight. I’m not smoking. I’m not drinking. Like there’s a responsibility that goes with, don’t want to take that medication. Right. And one of the other things is that, ⁓ if it wasn’t for the medical industry, I would not be here recording this, ⁓ podcast. Yeah. So there’s this big thing, which is. Jack Clifford (17:31)Yeah. Double-head sword, right? Yeah. Yeah. Bill Gasiamis (17:37)They’re not fixed. My brain is not getting fixed unless they go in and take out the faulty blood vessel and potentially risk all the complications that, that I got the ones I got, but also the ones I didn’t get, which many people get, which is far worse deficits than what I visible on me. So, ⁓ I’m, you know, I’ve never met anyone in my time who hasn’t Understanding Enhanced External Counter Pulsation (EECP) who has been through the medical ⁓ system, who hasn’t benefited from it in a way that’s sort of sustained their life, supported their life, lengthened their life. Like everyone that I’ve interviewed has always gone through the medical system and has saved them, supported them, helped them, right? And you’re going to, the first place to get help you’re going to is a hospital, right? You ring up and you go, I’ve got to go. Jack Clifford (18:22)Yeah. Bill Gasiamis (18:31)to the hospital because I’m feeling like I’m having heart attack. You get there, they confirm it, and then the place that you go to for help is the place you walk out of. What’s the thinking? Yeah, yeah. You have the angina, the blockages. Yeah, you got all of that. Jack Clifford (18:41)Well, I didn’t have a heart attack. That’s a really important nuance point. you know, I’m sitting in the hospital all weekend. there was nothing at risk in an emergent moment for me. My heart wasn’t, you know, I wasn’t going to lose heart muscle if they didn’t do something. Like my mother’s instance was different. She had a heart attack. She probably needed the bypass surgery. It was really hard on her, obviously, like we talked about, but in my case, I had time, but they didn’t treat it like I had time, right? Bill Gasiamis (18:54)Okay. Okay. Jack Clifford (19:10)They treated it like, we’re gonna go in and take care of this thing for you rather than you have time to explore other options when I knew in fact I did. So it might be that getting bypass surgery is the right move for some folks, but it also might be the right move for you and me. We’ve already discussed that you take care of yourself so you never get in that situation. And yeah. Bill Gasiamis (19:32)Yeah. And this is not a interview about do as I say, this is not that interview, right? What this interview is like one person’s experience and what they did. That’s it. We’re not giving medical advice here. We’re not telling you what decisions to make. We’re not telling you any of that stuff. This has got nothing to do with advising anyone to do anything, but what it has got to do with is what either you discovered Jack Clifford (19:45)Yeah. Right. Bill Gasiamis (19:58)or you knew before and put into action or what you discovered after you left the hospital that weekend. So take us through the next sort of phase of I’m taking responsibility for this and I’m going to take advantage of something that is documented scientifically and proven. Jack Clifford (20:03)Yeah. Okay. Yeah. Mm hmm. Yeah. Yep. Yeah. And you know, like, so I’ll go into that phase, but, but I just want to share this thing because, know, you, you pretty much already told me when you first heard EECP, you like EECP what? Right. And most doctors are EECP what? Basically every patient is EECP what? And it’s, it’s just, it’s really not going to lie. really bothers me because this, this, this therapy is, is so well-documented. It’s, it’s, it’s FDA approved. It’s not controversial. Bill Gasiamis (20:25)Mm-hmm. Jack Clifford (20:43)⁓ it just anyways, okay. So, so, so yeah, so I leave the hospital and the only reason I knew about a EECP was because when my mom had her heart attack, I listened to a podcast by Ben Greenfield. He’s a pretty, you know, pretty high-level guy, right? And that had been, that was like 2015. And I just heard mention of it. was like, it was maybe like two minutes of the, of a 60-minute podcast at most, but I was like noted. So I looked into it from my mom. The closest provider was two hours away and you got to go 35 times and my mom isn’t going to drive. 35 times, you four hours round trip. It wasn’t gonna happen, so we moved on, but I just sort of knew about it. And when I say knew about it, I didn’t know, Bill, like what it actually did or how it worked. I didn’t look into it at that level. just, you know, like assessed the situation. I was like, okay, there’s something out there. That’s it. Okay, yeah. It stands for enhanced external counter pulsation. And you want me to go into a little bit about how it works? Yeah, okay, so. Bill Gasiamis (21:27)Hmm. And what is a ⁓ CP stamp? What does it stand for? Yeah, yeah, let’s do that, yeah. Jack Clifford (21:42)So EECP involves lying on a bed. From the patient experience, you’re lying on a bed. You have ⁓ cuffs wrapped around your calves, your thighs, and your hips. And inside those cuffs, there are little air bladders. Bill Gasiamis (21:55)those cuffs, are they like blood pressure cuffs? The Mechanism of EECP Jack Clifford (21:58)Yeah, like big giant Velcro blood pressure cuffs. Yes. Bill Gasiamis (22:02)Okay, so like they’re much bigger than a regular cuff, which is just over the bicep. Okay. All right. Jack Clifford (22:04)Yes. Yes. Correct. yeah, just that’s the right way to think about it. you you cinch them up, you’re getting really snug in this thing, but it looks like a giant pantsuit, you know? ⁓ And you lie on the bed and then you get a three lead EKG on you. It’s here, here, in here. And then in between heartbeats, the machine… inflates compressed air into those bladders at 1.3 psi to start with, which feels like kind of a gentle massage. And then the pressure can be increased in increments of 0.1 psi all the way up to six, which feels like the exact opposite of a gentle massage. However, if you go slowly, your body accommodates to that pressure and that pressure feels different, both over one session and over multiple sessions, meaning you might not get to six your first session, that’s unlikely, but as you do repeated sessions, you’ll increasingly get closer to six earlier in the treatment and be cumulatively more hours at those higher pressures. And what’s happening is all the blood, not all the blood, a significant amount of blood from your lower body is being pushed up in between heartbeats and it’s causing this phenomenon called sheer stress in your vascular systemically. And wherever there’s pressure differentials in the body, it’s giving a stimulus to grow. It’s saying the pipes are not big enough, you gotta grow. We’re trying to put through more than is gonna fit. The body’s like, wait a second, it’s not big enough. But growing things in the body takes time. And so you need those repeated sessions. Like I mentioned, T.R., before we started recording, it works just like cardiovascular exercise, but at levels humans can’t do on their own. ⁓ And so, yeah. Bill Gasiamis (23:52)That’s important to talk about. so just for a moment, we’ll talk about that. Like it works like cardiovascular exercise. So the idea with cardiovascular exercise is that what, does cardiovascular exercise do that’s similar to EECP? Jack Clifford (24:04)Sure. If you’re out running, when you hit that stride on your feet, you’re doing that same thing, right? You’re ⁓ sending blood up, right? And then your circulation, your heart’s beating twice as fast maybe than it normally is, or substantially more than you’re just sitting here heartbeat is. And that’s because the heart is responding to the environment around it and saying, I gotta get… a lot more blood, a lot more places. So I gotta work a lot harder. you know, is maintenance. So collateral blood flow. have alternate routes that we can use that lie dormant throughout our body. And those collaterals, if they never get used, they honestly, they get weaker and they close off, but they also can be reopened, you know? And then you can grow more of them. And… Bill Gasiamis (24:38)And what’s the result of that? Uh-huh. Okay, so there’s blood vessels that get less ⁓ blood flow because people are sedentary or people aren’t doing the type of exercise that would activate those blood vessels, for example. And then what in theory, not in theory, and then what happens in cardiovascular exercise, the body goes, we need more blood flow, let’s open up. Jack Clifford (25:12)Exactly. Bill Gasiamis (25:26)other areas where normally blood flow wouldn’t be required or doesn’t go. And EECP kind of mimics that mechanism. Jack Clifford (25:27)Yeah. Exactly. Yeah, but not kind of, it’s really important just to note, cause I don’t want, I don’t want any of your listeners thinking, well I’m just going to go run more. Right? I mean, by all means do that safely. You know, the dose always makes the poison with everything, but, but don’t think that you can, you can just go do this. You can do it to a limited degree with exercise, but you’re not going to grow, you know. that I didn’t have that before. And I like it because it shows you like the world of the possibly or it might be a little unsightly, but it’s feeding my brain. EECP has changed my cognition in addition to my heart, you know, my pelvis and my kidneys and my liver. you know, like it’s, it’s optimized blood flow systemically. Um, yeah. Yeah. Bill Gasiamis (26:19)Okay, so let’s go back to the cuff, the cuff that we put on and then what happens. Jack Clifford (26:24)Yeah. Yeah. So, so you just lie on the machine. Typically you do 35 hours on a machine for a course of treatment and one hour a day is a typical, you know, five days a week. That’s just typically you’re going to the doctor. There’s lots of other variations of that, but that’s the typical course. And that’s the most well-researched course. And, ⁓ you know, over time, usually about halfway through those 35 sessions, if you had angina, you’re going to notice a difference, but Personal Transformation Through EECP you know, they use this to treat dementia. It’s a well studied in dementia. There’s a recent study in the US that was profound, a year-long study, a hundred demented patients, roughly a hundred non-demented or a hundred treated patients. Everybody had dementia and a hundred CHAM patients, placebo. The demented patients that got an EECP, they all got better when we know dementia, people get worse in a year, right? They all got better, all of them. And yeah, so that’s like, you know, similar phenomenon erectile dysfunction, similar phenomenon kidney disease, similar phenomenon stroke recovery. So, you know, these are studies. I’m not making it up. It’s just literally like really well documented. It’s not. Bill Gasiamis (27:33)studies that we can get a hold of and put in the show notes, link to the show notes. Jack Clifford (27:36)Yeah, go to to EECPLocator.com and all these studies are there. ⁓ Yeah. So what I did is in the U.S., I, you know, it’s really hard to find. so I couldn’t find it. I had to, I had to call around and like, I could find a few doctors, none of them near me, but a few of them that would had machines, but they would only use them after everyone had failed stints and failed bypass and they had nothing else to offer them, which makes no sense. But that’s how the insurance reimbursements work. Bill Gasiamis (27:41)Okay. Jack Clifford (28:04)That’s the only time they’ll actually pay for it. So that’s what they say it’s good for, but that’s not what it’s good for. That’s just what they can get money for, I guess. but, so I had to drive three hours and take a chance on a doctor and stay in a hotel to get my treatments. And it was really difficult. I mean, I ended up buying one of these machines and got it at my house and I’ve just been using it for the last five years. So, you know, 35 hours was great, but I was pretty bad off. Now I got about 700 hours and, uh, you know, more hours is just greater stimulus to the body to grow vasculature, right? And I mean, I… Bill Gasiamis (28:38)how do you know that you’ve grown? I know there’s this ⁓ feeling or this change that happens in the person. ⁓ Like you said, dementia, ⁓ people who experienced dementia have a better outcome later or a change in the way that they’re brain working, et cetera. can you see the, is there a way to see the difference between the blood vessels and Jack Clifford (29:02)You can’t, you can’t image, could image on a, on a cardiac pet would be like the only imaging or I guess, you know, if I went back and did a stress test again, you would, you would be able to see, cause it’s not quantifying specific arteries. It’s, quantifying the total volume, but I tried that they were, actually wouldn’t let me, they said it’s not safe because you have it at a stent or a bypass. So I went back to the same place that I got it, you know, and I was like, literally they put me through the imaging machine. gave me the dye and then they got Lifestyle Changes and Holistic Health I went to go on the stress test and the same doctor was there and he refused to tell me to go. So I like, wanted to say, hey doc, let’s go for a run. Cause like, you’re not going to keep up with me, but you know, so I, I didn’t bother with that, but I’ve got my own, you know, I did my own little stress, stress test with a treadmill, right? I started, I was getting chest pain. I found out where I can induce angina and I try and say just below it, you know, so I know where it is, right? I was 2.2 miles an hour. That’s not a fast walk. And then after the first 19 sessions where I was staying in the hotel, I got up to 2.7. That’s a really big difference even if it doesn’t sound like a lot. And then I got my machine and I kept going. And then within a couple of months, I was starting to do a running stride. And I could keep that up, no angina. I know where angina would come in. I had time calculations and everything. And then eventually, now I can run. comfortably 6.5 mile an hour pace for quite a while, know, push it up to 14 miles an hour for 30 second sprints and you know, like all kinds of stuff. So, ⁓ Bill Gasiamis (30:38)How long before you break the two hour barrier for the marathon? Like was recently done. Maybe, maybe the more blood vessels, the more blood flow. Maybe you can get there. Jack Clifford (30:42)⁓ I got zero interest in that. Yeah. I think so though, I think those Kenyans should be ⁓ hopping on these EECP machines and they’re I mean, they’re already amazing but. Bill Gasiamis (30:58)Well, you want the Kenyans to just completely own marathon running for the rest of eternity. It’s unbelievable what they did. Right. Like I imagine that there is something else going on there, but I imagine blood flow, oxygenation, more blood vessels. Like it’s got to potentially be a thing. reckon if you do a check between the last guy, me, who’s going to like 50 hours before you get to the other side and those dudes, there would Jack Clifford (31:03)Yeah, yeah, it’ll just be a Kenyan Yeah. ⁓ Bill Gasiamis (31:27)definitely be a difference because they’re exercising all the time, right? Jack Clifford (31:31)Sure, yeah, they’re pushing the collaterals as wide open as, know, whatever, whatever a human can do on their own, they’re doing it to the max to, know, the same phenomenon that EECP is doing for folks lying down. You know, they’re doing it to whatever the max you can without the machine, I would say. Bill Gasiamis (31:48)So this is a bog standard human body task. Like it just does that all the time. I have heard the blood vessels can reroute in the brain when somebody experiences a blockage and then, and it’s not useful at the time of the blockage, obviously, and it causes potential cell death when somebody has a stroke. But then later on. Jack Clifford (32:11)If there’s too much blood, the revascularization, yeah. Bill Gasiamis (32:14)Yeah, so EECP can kind of occur naturally and then it can support as much of the surrounding tissue as possible so that it doesn’t all die off. ⁓ So what you’re talking about is just encouraging EECP ⁓ to happen more than it would normally happen by ⁓ inducing it through this device where people ⁓ get sort of strapped in and then Jack Clifford (32:23)Yeah. Bill Gasiamis (32:43)the machine runs, what does it run like a program? Explain how that works. Jack Clifford (32:47)Literally, it’s just air pressure. got different pumps to pump the calves, the thighs and the hips up. And then it’s really just about the timing, right? It’s got to hit it at the right interval of your heartbeat. So it’s at the right place in diastole where your heart is at rest. that timing is very, crucial. And that’s really… Yeah, it’s not, it’s very old technology. The machine I have was built in 2009. You know, they have new machines that are portable now that I’m working with some of the manufacturers to actually, you know, make these available in the U S because there aren’t any in the U S but they do have portable machines that don’t require a bed. You could get treated on your couch. You could get treated, you know, on your own bed, uh, lying on the floor, I suppose. Um, so, you know, we’ve, we’ve really like technology hasn’t Bill Gasiamis (33:19)Wow. Jack Clifford (33:42)slowed down. just China’s like taking this thing and you know, have a basically every Chinese hospital has several of these machines and they treat patients in the, in the room with us. It’s, part of their standard of care for all kinds of different, different diseases that they’re treating. You know, and it’s adjunctive to just about everything. There’s nothing that you couldn’t do EECP with, right? ⁓ yeah. Bill Gasiamis (34:03)Okay, okay, so. How do you experience your body differently now? And actually, let’s go back actually, how long has it been since you came across this, decided to get the first treatment, implemented yourself ⁓ at home and then how do you feel different now? Jack Clifford (34:08)Oof. Yeah, it’s been five years and four months now. And every since like, this is this is a little hard part to quantify, because there’s been a lot of brain changes to from this, right? So so I don’t even like feel like my 47 year old self who was in the hospital, that feels really like somebody else to me. You know, it’s a version of me, I suppose, but I can’t really relate to that person. Because I like a small example. The Impact of Stress on Health I used to sleep eight to nine hours a night. That was my normal, my whole life. I was generally like the guy that would come in the latest. You could come to work. was the guy that came in the latest. You And now I get up at two 30 most mornings and I’m like, like rare to go with energy. I’m, you know, I’m working out doing resistance training. I’m reading, you know, I wrote a book, I’m writing another book. I’m writing a book on rectal dysfunction as it relates to this phenomenon, because that’s a whole other, you know, case study. and I work a full-time job and I just have an incredible amount of energy basically all the time. My mood is way better. My sense of touch is really different now. I give a lot more hugs because it feels really good. ⁓ My sense of smell and taste and… You know, hearing, you know, I used to like have to go to the bathroom at night sometimes, you know, wake me up to go to the bathroom. Long gone. Bill Gasiamis (35:47)So at the same time though, it sounds like also you might have changed other things as well though, right? So what else have you changed in the meantime? Jack Clifford (35:55)sure. Yeah. Yeah. Yeah. It hasn’t just been EECP. Absolutely. you know, really good supplement routine. ⁓ Pretty extensive, but, you know, managing my lipids, for example, I take a thousand milligrams of niacin twice a day. I’ve been able to bring my triglyceride to HDL ratio to kind of an optimal one-to-one, using fish oil and some other things. ⁓ And, you know, I… I really stay away from carbs for the most part. I like to eat keto, but I like it to be what I call clean keto. So I’m not like pounding keto ice cream or all these things that are, you know, they taste good and yeah, they’re keto, but they got all kinds of oils in them that aren’t really good for your body. ⁓ And, ⁓ you know, I’m big into moving and being active and, you know, having an engaged social life as much as possible as well. I mean, I think that’s a very underrated thing. That’s actually an area I struggle in because I’m working so much, but you even this helps just, you know, getting to know people even online. But, ⁓ Bill Gasiamis (37:04)It sounds like you haven’t re it doesn’t sound like you’ve reinvented the wheel. Like everything that you say is things that people take for granted that if they implemented would improve their life before EECP. We’re talking about EECP today, right? But just those things alone would make a massive difference to somebody’s experience. And that’s kind of the message that I’m trying to kind of get into the Jack Clifford (37:17)Totally agree. I thought it a good Sure. Bill Gasiamis (37:30)⁓ minds and hearts of the stroke survivors who I interview and who listened to the podcast. My book, I’m going to, we’re going to talk about your book in a sec, but I’m going to talk about my book. My book, when I wrote it, I thought I discovered all these things that people, should know about that no one knows about, but it’s not true in here is mindset. ⁓ there’s a chapter about emotional intelligence. There’s a chapter about nutrition. There’s a chapter about sleep. There’s a chapter about community. Jack Clifford (37:32)Yeah. Yeah. No, please. Bill Gasiamis (38:00)⁓ that’s just the five that I can just rattle off the top of my head right now. And you’ve already mentioned that in the last few minutes, that’s exactly the things that you mentioned. And people take it for granted how much that improves your overall health. Right. The Journey of Writing a Book Jack Clifford (38:13)That’s so true. And also what’s wrapped up in the wrapper of all of those things that are threaded together is stress, right? ⁓ If you do all of those things, right, you’re lowering stress. How did I get heart disease at 47 when it happened to my grandfather in his late 60s and my mom in her mid 60s and it happened to me at 47? And we know it didn’t happen at 47. It was years earlier and I realized it at 47. Stress, you know? Like I was the guy that took on a lot. Bill Gasiamis (38:38)Hiding earlier. Jack Clifford (38:44)and had some traumatic things happen in my life and whatever, and I don’t need to go into that. But I always felt like it was all rolling off my back. Like, you know, I’m fine. know, like I didn’t, and there are reasons why I felt that way. ⁓ However, at the end of the day, I know that I wasn’t processing. There was so much I did not process. And I didn’t learn how to like have really good boundaries and that, you know, begot more stress because of those lack of boundaries and, but stress, right? You know, like, but if you have good good social life and healthy people in your lives, that takes stress off. Eating the right food takes oxidative stress off your body. You could go on and on, but I think stress is gonna kill you before anything else. Bill Gasiamis (39:17)you Yeah. I love that you said that. I love what I love that. That was the answer that you gave when I said, what else did you do? Because it’s not just, you know, it’s like, I’m going to eat well, but smoke, you know, I’m going to eat well, but drink excessive amounts of alcohol. Like, no, it doesn’t work. You know, you can’t do that. Yeah. can’t do. Yeah. Small. Jack Clifford (39:42)No, you gotta do it all in concert. It’s the layers, right? Yeah. Bill Gasiamis (39:49)numbers, know, the percentages they add up, you know, 1 % here, 1 % there all adds up and you get a result at the end of it. Okay. So, so you’re you’ve gone, I’m going to see if I can grow new blood vessels to support my heart. And what you’re found between the time that you went to hospital around five years ago to now is that the angina has Jack Clifford (39:55)Yeah. Mm-hmm. Bill Gasiamis (40:17)⁓ improved, they’ve gone away. The heart has improved, I beg your pardon, the blood flow. And have you had a medical examination since then to do other comparison? Jack Clifford (40:28)Yeah, I have. Yeah, I’ve got a cardiologist. I haven’t seen him and I’ve talked to him the other day because I talked about the book, but I haven’t gone to see him because he’s a plane flight away. But I’ve been worked up for the crowded intermediate thickness. You might be familiar with that as it relates to stroke. okay, well, they just measure your crowded arteries and look at the placking in your crowded arteries as a proxy for your systemic plaque burden. And flow mediated deletation, is they totally occlude the… the arm with a blood pressure cuff and then see how quickly you can refill it after, you know, like, it’s like five minutes of this, your hand is completely numb. And those all, you know, workups were good and that was after a couple of years of treatment. You know, I tried to have that stress test, like I mentioned, but you know, now I just see my primary care, you know, he’s a good guy and he runs on my lipid panels and, ⁓ you know, so I’m definitely monitored, but. What I haven’t done is gotten re-imaged because I don’t want to put extra dye in my system. Sure, somebody wants the images because they don’t believe me, but I’m not trying to sell anybody anything here. I’m just trying to spread the word on something. If somebody doubts my honesty, they can, it’s fine. Bill Gasiamis (41:38)I know what you mean, Jack. I know what you mean. I and I asked you because yeah, I would love to see that before and after. would love to see the blood flow. What’s happening, watch change. would be amazing. story to tell, but I also went out of my way if I could to avoid having more dyes and all that kind of stuff injected into my body. I totally get it. It’s okay. Yeah. ⁓ Jack Clifford (41:49)Yeah. Yeah. Yeah. Bill Gasiamis (42:01)Okay. So you wrote a book about it. Like, what was the idea behind the book? What were you thinking? Show us the one that you got there with the old book cover. And then I’ll include the new book cover in this image as we chat. Jack Clifford (42:06)yeah. Yeah. Yeah. Yeah. Thanks. Yeah. So I started writing this book, in, know, ⁓ November timeframe, ⁓ after I mentioned to you, so my, my friend came down, ⁓ and stayed with me for 13 days and he had had some stroke damage five years before that was, you know, his whole right side, he just had like numbness and then pain. And then, you know, it this weird cascade of symptoms so bad, you know, sometimes he couldn’t sleep from it. And so All the time he took off work he could he came and he used the machine three times a day and then he left pain free and like nothing else had worked and then this worked and I didn’t per se expect that I but I was like, you I know it does stuff. It’s helpful. But anyways, when I saw that, you know, I really started digging even more because before that I was like, well, Jesus is amazing. But maybe it’s just me, you know, and and anyways, so, ⁓ so then I, you know, I just started writing the book one day and The Role of EECP in Heart Health You know, my mom was a book author and I always wanted to write a book. didn’t really have anything particular to write about and all of sudden I do. So I’m like, you know, let’s see what happens. And, uh, and you dig into the research more and more, and you’re just like, increasingly frustrated by how everyone has known about this. And yet, you know, they don’t promote it. They don’t talk about it because it’s inconvenient. You know, and I’m going to get a little, try not to get like soapboxy here, but Bill Gasiamis (43:36)Do it, do it, go for it man. Jack Clifford (43:37)Okay, okay, because, you know, cardiologists will say it, some of them, the ones that are honest, they’ll be like, like mine. He says, I was making obscene amounts of money, giving people bypass surgeries instance. And then I was given the same people bypass surgeries instance, a couple years later. And, you know, and then he stumbled upon some answers and EECP is one of them that helps his patients stay well. And, you know, he makes a lot less money. because of it, because he doesn’t go in and do these interventional approaches. And, you know, EECP, the most you could pay somebody is like $100 an hour, and you’re going to tie up a patient room for 35 hours with a tech, it doesn’t make any sense. I go pop a stint and you make 10 grand in two hours and never see you again. You know, like it just, I get it from, you know, I want to own a portion of Ferrari and have a lake house and a winter house, but You know, like, I don’t know how you live with yourself. You said go for it, man. I’m going to go for it. you know, and my son’s about to graduate. Okay. Yeah. Okay. Fair enough. I’m good with it. Yeah. Yeah. Bill Gasiamis (44:38)But come on, come on, Jack. Yeah, you go for it. I’m going to push back. I’m going to push back as well. You go for it. I’ll push back. There’s yeah. Which is cool. Right? That’s what I want. I want to have a conversation and I don’t want to control the narrative, but the guy that goes in needs a stint today has a blockage. Like that’s life saving. That does work. What I am afraid of that happens sometimes when people go in and they’ve got a blockage and then they get ⁓ even even a stroke blockage. Right. in carotid or a vertebral artery. What happens is sometimes people go in and they get told you need a stent. Fair enough. You’re about to have a heart attack. You’re about to have a major stroke. If we don’t put one in, you’ll have a, that’s necessary. The challenge is, that that person sometimes doesn’t learn the lesson of what got them into the situation where they need a stent. Jack Clifford (45:22)Good. Exactly. sure. Yeah, by all means. Like emergency medicine is great. And we’ll put that in the emergency medicine category of cardiology, right? Why aren’t they offering you, why aren’t they saying, Hey, you’re at risk for a whole lot of other things just by this happening. Why don’t you come 35 times to this EECP machine and you know, like, or why don’t we have centers Bill Gasiamis (45:36)Yeah. Yes, and then later… Jack Clifford (45:55)all over. I found exactly one place in Australia so far that I’m not focusing on Australia right now. I do plan to take EECP Locator International, but right now the access points in the US are abysmal. 70, 80 % of the people in the United States could not get to a center. There’s no access point that’s at all realistic for them to get to. And yet these machines are not that expensive. They’re the price of a Decent not that great car. ⁓ Bill Gasiamis (46:24)we’re starting to see them in, I don’t know, health spas or something like that, where people will go, they’ll get yoga, they’ll get this, they’ll get that, they’ll get infusions perhaps and all sorts of other things. And there’ll be a machine or there’ll be a suit that people can put on and they can go through one hour. Jack Clifford (46:29)Yeah, that’s good. That’s great. Yeah, although I do want to say that the Normatech, like the compression boots that they have and some of those things, when they don’t use the pressures that EECP uses up to 6 PSI and they’re not sinking it in between heartbeats, it’s helpful, but we’re not talking about things that can do the same thing in the body. It’s on the right path and I’m not digging it as being worthless because it’s not, but it’s just not the right thing. Bill Gasiamis (46:47)Yes. Yeah. Yeah. Yeah, that’s kind of what we’re seeing. And to go back to your point is because the medical profession does medical profession stuff. this is not, it’s not that it’s not medically kind of aligned. It definitely is. But when you’re told that the way you solve a problem is through putting a stent in and then never talking to that patient again, to tell them how to avoid to get a stent in that’s Jack Clifford (47:31)Yeah, that’s your job. Bill Gasiamis (47:34)what they do, like they’ve been trained to do that forever. And that’s what they do. And that works and it saves the life. But what it doesn’t do, which I also have a challenge with this, it doesn’t teach the lesson. What it reinforces is that if I have something wrong with me and I go to a doctor, they’ll fix it. So next time it goes wrong, I’ll just go to the doctor and they’ll fix it again. And I didn’t have to change my life. Like this even bloody advertisements that do that. They Jack Clifford (47:51)just I’ll go and he’ll fix it. Yeah. Yes. Yes. Bill Gasiamis (48:03)They hijack that part of the person’s brain and they say, you know, have you got reflux, heartburn, that kind of stuff? Don’t let reflux and heartburn get in the way of eating the foods that you love. Just take a tablet. You know, that’s the same kind of thing, right? And that’s why the medical profession doesn’t do that because they’re not trained to do anything other than sell their thing. And their thing is what they went to work, to school for. Raising Awareness for EECP Therapy Jack Clifford (48:17)Yes. Bill Gasiamis (48:30)20 years to be able to administer. But every so often you come across an amazing doctor, surgeon, et cetera, who says, I can’t do anything more for you, but maybe somebody else can. Those guys are better than the doctor who says, we can’t do anything else for you and then send you off their way. That next sentence, but maybe somebody else can, I don’t know who they are. That is. Jack Clifford (48:43)Mm-hmm. Bill Gasiamis (48:57)I think a great thing to say this is where I think EACP kind of fits in that now that I’m here and things are not good. Jack Clifford (49:05)I totally agree. I totally agree. And yeah. And you, so you, you mentioned like the wellness spas and whatnot. And here’s the thing in 2015. So, you know, somewhat recently the FDA approved EECP for a brand new indication, general circulation, right? In healthy people. Like it’s right on the FDA indication. And also in one case in increase in VO2 max, but rough, that’s roughly saying the same thing. ⁓ yeah. Bill Gasiamis (49:32)for healthy people, was that part of it? Jack Clifford (49:35)Yeah, it said unhealthy patients and healthy people didn’t call patients. So, so, ⁓ but, but, know, the litmus test for that is, is your doctor say you’re healthy enough to undergo circulation enhancement? If the answer is yes, you know, it doesn’t matter if you got all that other stuff or not, you know, we’re just not treating you for it. We’re not saying ECPs is fix for this, your erectile dysfunction. It might help it. You know, what’s not saying it’s, it’s the fix for your stroke, but it might really help your stroke, recovery, but. Bill Gasiamis (49:47)which Jack Clifford (50:03)Anyhow, so like you can, you know, I don’t know about in Australia, but in the United States, you could get an EECP machine and create a viable business model off of helping people as soon as people actually know about it and what it does, right? I’m trying to solve the access issue in the United States by aggregating demand, right, as one of the solutions. So I have a website, eecplocator.com. And if people… ⁓ tell me that they like EECP to be available in their area, when I get like five to 10 patients in one area, we’re gonna find a way to get it to them. ⁓ The how is, you there’s a bunch of different possible ways we can get EECP to them, but at the end of the day, you know, like people need this treatment. They really, really do. Bill Gasiamis (50:50)Yeah. We’re not talking about anything ⁓ out there. Like this is not an out there thing. This is definitely common. Now I, I don’t know how I haven’t come across it. I’ve all these years after all these years now I’ve just because of our conversation right now, I just did a Google search and I typed in EECP machine Australia. And the first thing that came up was an Australian government department of health, disability and aging. Jack Clifford (50:57)No, it’s that. Bill Gasiamis (51:20)document from the Therapeutic Goods Administration, which talks about a mid-trade Australia EECP system model, external counter pulsation system stationary. So it seems like they have a… Jack Clifford (51:36)Like they’ve approved it, sounds like they have some approved devices. Yeah. Bill Gasiamis (51:38)Something like they’re at least looking at it. Let me see what that says. The inclusion of the kind of device in the AI community is subject to compliance with conditions placed in post. Yeah, it sounds like it’s been through some regulated body in 2021. Jack Clifford (51:52)Yeah. Mm-hmm. Yep. There you go. Bill Gasiamis (51:57)This device is intended to provide external counter pulsation therapy and is indicated for use in the treatment of stable angina. Jack Clifford (52:06)Mm-hmm. Bill Gasiamis (52:08)pectoris and congestive heart failure. There you go, my friend. Jack Clifford (52:10)Yeah, it works great for people with art failure. It really does. Bill Gasiamis (52:14)Dude, father-in-law had heart failure. He passed away from heart failure just a few, about a year and a half ago. ⁓ Now, I don’t know, I’m not saying anything, but we’ve never heard of this before. Today’s my first time where I’m really going to deep dive about this thing with you. ⁓ So what are the challenges that you face? what are the, what is it? ⁓ The barriers that you face? Jack Clifford (52:20)Yeah. Bill Gasiamis (52:44)when you’re speaking to people about this or how people finding out about it, how do you help people like Jack Clifford (52:50)It’s just an awareness piece. It’s an EECP what? And then, you you get in with some physicians and then you got to duke it out a little bit. Not with all of them. There’s plenty of physicians, you know, I’ve talked to the physicians that have machines and are doing the right thing for society and still making plenty of money. ⁓ They’ll just tell you, you know, I’ve talked to some cardiologists and just they kno

Content note: this episode discusses assisted dying, end-of-life choices, and suicide. Some listeners may find the content distressing.In April 2024, Daniel Kahneman — one of the most influential psychologists of the twentieth century — emailed his close friends to say goodbye. He was 90 years old, his kidneys were failing, his mental lapses were increasing, and he had decided it was time to go. He flew to Switzerland to end his life at an assisted dying clinic there, because New York, where he lived, did not permit it. Thirteen American states currently allow medical assistance in dying; most require a terminal diagnosis with death expected within six months. Canada, Belgium, and Switzerland allow it on broader terms. The UK introduced a bill to parliament, but it failed to pass. The debate on whether we have the right to end our own lives has not been resolved. This week Tim Phillips talks to Al Roth of Stanford University about how economics can contribute to the debate on medical aid in dying (MAID). Roth, a Nobel Prize laureate, has written a new book that argues this, and similar debates, often miss the key insight: the binary choice of “allow” versus “ban” rarely reflects reality. For example, in the United States, he explains that physicians in jurisdictions where assisted dying is illegal are familiar with the practice of administering doses of drugs that will relieve pain, but also end life. Roth's argument is not that assisted dying is always right. It is that a moral position that ignores the costs of a ban is not more ethical — it is less honest. Economists, he says, bring one specific thing to this debate: the insistence that trade-offs be made explicit.The book discussed in this episode:Roth, Alvin E. 2026. Moral Economics: What Controversial Transactions Reveal about How Markets Work. Basic Books. Published 21 May 2026.To cite this episode:Phillips, Tim, and Alvin Roth. 2026. “The right to choose to die." VoxTalks Economics (podcast).Assign this as extra listening. The citation above is formatted and ready for a reading list or VLE.About the guestAlvin Roth is the Craig and Susan McCaw Professor of Economics at Stanford University. He was awarded the Nobel Prize in Economics in 2012, shared with Lloyd Shapley, for the theory of stable allocations and the practice of market design. He is one of the architects of modern matching market design, having redesigned the systems used in the United States to match medical residents to hospitals and students to schools. A previous book, Who Gets What — and Why, was published in 2014. Research cited in this episodeRepugnant transactions is Alvin Roth's term for a class of transactions that are controversial not because no one wants to engage in them — that would be disgust — but because some people do want to engage in them and others believe they should not be allowed to, typically on moral or religious grounds. The key feature is that the objectors suffer no direct externality from the transaction; their objection is to the thing happening at all, regardless of whether it affects them. Roth's examples across the book include medical aid in dying, kidney sales, paid blood plasma donation, surrogacy, and access to certain drugs. The policy implication is that repugnant transactions, unlike ordinary market failures, cannot be resolved by standard economic tools; they require explicit engagement with the moral contest and careful mechanism design to decide what is permitted, to whom, under what conditions.Oregon's Death with Dignity Act (1997) was the first US state law permitting physician-assisted dying. It requires a terminal diagnosis with death expected within six months, confirmation from two physicians, a waiting period, and self-administration of the medication by the patient. According to the 2024 report of the Oregon Health Authority, assisted dying accounts for roughly 0.9% of all deaths in Oregon; many patients who obtain a prescription never use it. Oregon's 27 years of data make it the most-studied model for the policy, and its take-up rates and population demographics have informed both advocates and critics in other jurisdictions.Ezekiel Emanuel and vulnerable populations: A 2016 paper by physician and bioethicist Ezekiel Emanuel and co-authors examined the demographics of patients who access assisted dying in jurisdictions where it is legal and found no evidence that vulnerable populations — defined by disability, age, mental illness, or socioeconomic status — accessed it at higher rates than the broader population of dying patients. Roth cites this as evidence against the argument that legalisation creates pressure on the vulnerable to choose death, while noting that this population-level finding does not rule out individual cases of pressure.The Hippocratic Oath is the earliest recorded professional commitment by physicians not to participate in assisted dying. Roth notes that Hippocrates formulated the oath in the fifth century CE, and that the very inclusion of a prohibition on helping patients die implies the practice was already occurring — physicians were being asked to do it. The religious objection — that decisions about life and death belong to God — and the medical objection — that a physician's role is to save life, not end it — have both been consistent features of opposition to assisted dying across more than two millennia.The Canadian Supreme Court decision (Carter v. Canada, 2015) struck down Canada's criminal prohibition on physician-assisted dying on the grounds that it infringed Canadians' constitutional rights to life and to security of the person. The court's reasoning included the counterintuitive argument that denying access to assisted dying could cause people to end their lives earlier and less safely — while still capable of doing so — out of fear of being unable to later. The Canadian framework that followed is more permissive than US state laws: it does not require a terminal diagnosis but instead an irremediable condition causing intolerable suffering. Canada has since debated, and repeatedly delayed, extending the framework to mental illness as a sole underlying condition.Mechanism design is the field of economics concerned with designing rules, institutions, and processes to achieve desired outcomes, particularly in settings where participants have private information or conflicting interests. Roth is one of its leading practitioners. In the context of assisted dying, mechanism design asks: who can apply, through what process, verified by whom, with what waiting periods, and with what safeguards against coercion or mistaken diagnosis? The differences between Oregon's model (terminal diagnosis, self-administration, annual reporting), Canada's model (irremediable suffering, physician or nurse practitioner administration permitted), and Switzerland's model (available to non-residents) are, in Roth's framing, different mechanism designs with measurably different outcomes.More VoxTalks Economics episodesIn February, Tim spoke to Martin Ellison and Julian Ashwin about what decisions seniors will take about their later years and whether policy can accommodate both their abilities and their needs. Listen to The Economic Consequences of Living Longer. 

What if every time you reached for a packaged snack… you were quietly increasing your risk of a heart attack? In this urgent and deeply personal solo episode, Darin breaks down groundbreaking new research showing that each serving of ultra-processed food may increase cardiovascular risk by over 5%, not over time, but every single time you eat it. This isn't about calories. It's about chemistry, biology, and a system engineered for convenience at the expense of your health. From the shocking data to the underlying mechanisms: gut destruction, visceral fat accumulation, brain hijacking, and toxic exposure, this episode exposes the real cost of ultra-processed food and gives you the tools to reclaim control of your health and your life. What You'll Learn The shocking stat: 5% increased heart risk per serving of ultra-processed food Why ultra-processed foods act like compounding debt on your health The difference between calories vs chemical toxicity in food How emulsifiers and additives destroy your gut microbiome Why ultra-processed foods increase visceral fat around your organs How these foods are engineered to override your brain's satiety signals The hidden toxins from processing and packaging (PFAS, bisphenols, AGEs) Why this crisis disproportionately impacts certain communities The truth: you can't "out-exercise" ultra-processed food damage Practical ways to transition back to real, whole foods Chapters 00:00:04 – Opening: SuperLife mission and setting the stage 00:00:33 – Sponsor: Alkemis Paint and hidden indoor toxicity 00:01:24 – Why conventional paints off-gas harmful chemicals for years 00:02:27 – Cradle-to-Cradle certification and non-toxic living 00:03:24 – Entering the episode: the 5% heart risk question 00:03:34 – The shocking claim: every serving increases heart risk 00:04:16 – Ultra-processed food as "compounding debt" 00:05:08 – Leaning into discomfort as a path to growth 00:06:33 – The convenience trap: food delivered instantly 00:07:15 – The real cost: trading time for lifespan 00:08:07 – 2026 study overview (MESA dataset, 6,800 participants) 00:09:01 – 5.1% increased cardiovascular risk per serving explained 00:09:29 – 66.8% higher risk in high-consumption groups 00:10:08 – Risk is independent of calories, weight, and fitness 00:10:56 – "This is not a calorie story—it's a chemistry story" 00:11:10 – Racial disparities and food system inequality 00:12:08 – Additional studies confirm elevated heart risk 00:13:04 – Global meta-analysis: over 1 million participants 00:13:26 – The conclusion: the science is no longer debatable 00:14:18 – Sponsor: Shakeology and nutrient density 00:15:36 – What is ultra-processed food? (NOVA classification) 00:16:18 – Examples: chips, cereals, protein bars, fast food 00:16:57 – "These foods are engineered—not real food" 00:17:00 – Mechanism #1: gut microbiome disruption 00:18:03 – Emulsifiers and inflammation explained 00:18:49 – Gut inflammation triggers systemic disease 00:19:18 – Mechanism #2: visceral fat accumulation 00:19:56 – Why visceral fat is more dangerous than visible fat 00:20:18 – Mechanism #3: brain hijacking and satiety override 00:20:47 – Engineered foods and addictive eating patterns 00:21:04 – Mechanism #4: toxins from processing and packaging 00:21:30 – PFAS, bisphenols, and chemical contamination 00:21:37 – The solution: whole food first 00:22:02 – Breaking habits and reclaiming control 00:22:20 – Simple swaps: fruit, nuts, whole ingredients 00:23:00 – "If you can't trace it back to a real food, put it down" 00:23:32 – Making whole food convenient 00:24:06 – Batch cooking and preparation strategies 00:24:16 – Personal story: losing a friend to diet-related illness 00:24:40 – The emotional reality: this is life or death 00:25:00 – Community support and accountability 00:25:25 – Call to action: share this message 00:25:41 – Closing: courage, awareness, and living a SuperLife 00:26:23 – Outro Thank You to Our Sponsors: Shakeology: Get 15% off with code DARINO1BODI at Shakeology.com. Alkemis Paint: Go to https://alkemispaint.com/ and use code DARIN10 for 10% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Every time you reach for ultra-processed food, you're not just making a small decision—you're compounding a biological cost that your body has to pay later. But the moment you become aware, you reclaim your power. Because the same way those choices can slowly take your health away… different choices, repeated daily, can give it all back." Bibliography/Sources Primary Study — News Hook Haidar, A., Rikhi, R., Watson, K. E., Wood, A. C., & Shapiro, M. D. (2026). Association between ultraprocessed food consumption and cardiovascular disease risk: MESA. JACC: Advances. https://doi.org/10.1016/j.jacadv.2025.102516 Supporting Studies — 2026 Willett, Y., Yang, C., Dunn, J., et al. (2026). Consumption of ultra-processed foods and increased risks of cardiovascular disease in U.S. adults. The American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2026.01.012 Systematic Reviews & Meta-Analyses Dose-response meta-analysis: UPF consumption and cardiovascular events risk — 20 studies, 1.1M participants. (2024). eClinicalMedicine. https://doi.org/10.1016/j.eclinm.2024.102480 Ultra-processed foods and cardiovascular disease: Analysis of three large US prospective cohorts and a systematic review and meta-analysis. (2024). The Lancet Regional Health – Americas. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00186-8/fulltext Mechanisms — Gut, Inflammation & Additives Ultra-processed foods and cardiovascular diseases: Potential mechanisms of action. (2021). Advances in Nutrition. https://pmc.ncbi.nlm.nih.gov/articles/PMC8483964/ Ultra-processed foods and food additives in gut health and disease. (2024). Nature Reviews. https://pubmed.ncbi.nlm.nih.gov/38388570/ Ultra-processed foods and incident cardiovascular disease in the Framingham Offspring Study. (2021). Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2021.01.047 Ultraprocessed foods and their association with cardiometabolic health: A science advisory from the American Heart Association. (2023). Circulation. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001365 Visceral Fat Konieczna, J., et al. (n.d.). Contribution of ultra-processed foods in visceral fat deposition: Prospective analysis nested in the PREDIMED-Plus trial. Clinical Nutrition. https://www.explorationpub.com/Journals/edd/Article/100523 NOVA Classification Monteiro, C. A., Cannon, G., Levy, R. B., et al. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936–941. https://pubmed.ncbi.nlm.nih.gov/30744710/ Policy & Public Health Context American College of Cardiology. (2025). ACC 2025 concise clinical guidance: Front-of-package labeling endorsement. Journal of the American College of Cardiology. U.S. Departments of Agriculture and Health and Human Services. (n.d.). Dietary guidelines for Americans, 2025–2030. https://www.dietaryguidelines.gov General Coverage — News Hook Food Safety Magazine. (2026, April). Study links diets high in ultra-processed foods to increased heart attack, stroke risk. https://www.food-safety.com/articles/11290-study-links-diets-high-in-ultra-processed-foods-to-increased-heart-attack-stroke-risk ScienceDaily. (2026, March). Ultra-processed foods linked to 67% higher risk of heart attack and stroke. https://www.sciencedaily.com/releases/2026/03/260319074604.htm

There's a version of you that wants more. Deeper relationships, bigger moves, fuller expression. But there's also a quieter force at play. The part of your brain that keeps you “half in.”In this episode, we're unpacking the self-protective mechanism that holds you back from going all in. How it shows up in your relationships, your career, and your growth, and why it can feel so convincing.You'll learn how to recognize when you're holding yourself at a safe distance and what it actually takes to fully show up for the life you say you want.If you're ready to stop circling and start leading yourself forward, you can book a free 60 minute consultation herehttps://www.macierenae.com/

This lecture discusses key ideas from the 20th century pessimist philosopher and environmentalist Peter Wessel Zapffe's "The Last Messiah" It focuses specifically on the third of the four "suppression mechanisms" that he identifies, which he calls "diversion". It might also be accurately called "distraction", and involves keeping our attention and consciousness occupied by a succession of changing contents. He discusses a number of ways in which we engage in this ranging from entertainment to projects, even religious life and commitments. To support my ongoing work, go to my Patreon site - www.patreon.com/sadler If you'd like to make a direct contribution, you can do so here - www.paypal.me/ReasonIO - or at BuyMeACoffee - www.buymeacoffee.com/A4quYdWoM You can find over 3500 philosophy videos in my main YouTube channel - www.youtube.com/user/gbisadler Get Zapffe's The Last Messiah - https://openairphilosophy.org/wp-content/uploads/2019/06/OAP_Zapffe_Last_Messiah.pdf

This lecture discusses key ideas from the 20th century pessimist philosopher and environmentalist Peter Wessel Zapffe's "The Last Messiah" It focuses specifically on attachment as one of the four "suppression mechanisms" he discusses in the essay, which involves creating fixed points in or a wall around the shifting chaos of consciousness. This occurs at the individual, the interpersonal, and the societal level, and older attachments can often be replaced by newer attachments To support my ongoing work, go to my Patreon site - www.patreon.com/sadler If you'd like to make a direct contribution, you can do so here - www.paypal.me/ReasonIO - or at BuyMeACoffee - www.buymeacoffee.com/A4quYdWoM You can find over 3500 philosophy videos in my main YouTube channel - www.youtube.com/user/gbisadler Get Zapffe's The Last Messiah - https://openairphilosophy.org/wp-content/uploads/2019/06/OAP_Zapffe_Last_Messiah.pdf

This Week In Startups is made possible by:Sentry - https://sentry.io/twist Deel - https://deel.com/twist Netsuite - https://netsuite.com/twist Plaud - https://Plaud.ai/twistToday's show:*TAO just had its worst week since launch. One of Bittensor's most prominent subnet operators allegedly dumped $10 million in tokens and walked away. We're digging into what we know, how this could change the Bittensor community… and why dedicated builders still believe in this ecosystem.Jason and Lon are joined by Stillcore Capital Partner Mark Jeffrey to break down the Covenant AI and Templar controversy in real time. Then they're joined by three prominent subnet founders: Ken Miyachi of BitMind (Subnet 34) and Will Squires of Steffen Cruz of MacroCosmos (which owns Subnets 1, 9, and 13). Together, they're investigating how Bittensor incentives work, how real products are still emerging from the TAO ecosystem, and what governance fixes could arise to prevent the next (alleged) rug pull.Timestamps:0:00 Mark Jeffrey joins the show! https://x.com/markjeffrey2:18 How Mark Jeffrey learned about Bittensor. https://bittensor.com/6:17 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!7:22 Mark Jeffrey's Bittensor investments. https://stillcorecapital.com/9:25 Check out our discussion with Nova: https://youtu.be/gjRt4eUyiYc?si=HopdmmSarxECark110:16 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST10:41 Check out Ridges! https://www.ridges.ai/11:53 How trading alpha tokens works on Bittensor12:44 Subnet drama: what happened? https://x.com/covenant_ai/status/204238015283195130016:01 Do subnet owners have too much power?18:33 Check out our conversation with Sam Dare (2268): https://youtu.be/TN2RmNuX4-k?si=c58Byh7Fsw1ttnAY19:10 How Sam Dare should've handled walking away (per Mark Jeffrey)20:02 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.23:29 Who should subnets be owned by?24:02 Ken Miyachi from BitMind joins the show https://x.com/kenmiyachi30:56 Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist31:06 Ken's $3M raise & investors (Arch, Canonical, Mechanism)33:18 Token vs. equity: how to think about a subnet investment.41:57 Will Squires and Stefan Kruse of MacroCosmos join the show https://x.com/willsquires https://x.com/sczsteffencruz56:29 Stefan on the Covenant drama: "disappointing, but solvable"1:02:11 Off-duty with J-Cal, Mark Jeffrey, and Lon Harris1:02:48 Bieber vs. Carpenter: does Coachella owe you a spectacle? https://www.youtube.com/watch?v=hp5O72WUqTk https://x.com/FashionXGirl_/status/20432512705095929361:15:20 Jason says Staples should pay the "Staples baddie" $1M/year https://www.tiktok.com/@blivxxSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

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In this episode, Roxy returns to the pod to help Julia explore the fascinating history of scent: from ancient Greek perfumers on Aphrodite's island to Abercrombie cologne cloud terrorism. Plus, the girlies explain why smell is uniquely different from all our other senses, the Proustian relationship between scent and memory, and how capitalism has transformed our desire to smell good into a billion dollar identity crisis. Digressions include being flexed on by your parents, a man who generously donated his hair to a horse, and society's collective Mrs. Meyer's trauma. This episode was produced by Julia Hava and Kylie Finnigan and edited by Livi Burdette.  Roxy's Website: https://rjamin.net/ SOURCES 3,200-Year-Old Mesopotamian Perfume Recreated from Ancient Text     A Brief History of Scent  A Cultural Autopsy of the Celebrity Perfume  A Journey Through Time in Fragrance  Abercrombie Employees Have To Spritz Clothes With Cologne Every Hour Alain Corbin The Foul and the Fragrant: Odor and the French Social Imagination Aroma: The Cultural History of Smell  Cleopatra May Have Once Smelled Like This Recreated Perfume  Effects of ambient odors on slot-machine usage in a Las Vegas casino. Fragrant by Mandy Aftel History of the Hero: Chanel No5 How Advertisers Convinced Americans They Smelled Bad  How Coco Chanel changed the course of women's fashion I'm the Perfumer Who Created the Scent You Love to Hate — Abercrombie & Fitch's Fierce   In France's Perfume Capital Of The World, There's A World Of Beautiful Fragrance  Love Stinks: The Association between Body Odors and Romantic Relationship Commitment  Many find the term 'Oriental' offensive. Why are perfumers still using it?  Perfume Culture Is Starting to Stink  PERFUMERY The psychology and biology of fragrancе Psychology of Fragrance Use: Perception of Individual Odor and Perfume Blends Reveals a Mechanism for Idiosyncratic Effects on Fragrance Choice Poor Sense of Smell Linked to Increased Risk of Depression in Older Adults  Tappūtī-Bēlet-ekallim, The Oldest Perfumer on Record The Connections Between Smell, Memory, and Health  The effects of scent on consumer behaviour  The mysterious sense of smell: evolution, historical perspectives, and neurological disorders The Mystery of Ambergris  The proust effect: Scents, food, and nostalgia  The Smell of Evolution The Truth About Pheromones  The Ugly History of Beautiful Things: Perfume This Is What Space Smells Like You don't say? The smell of love You Might Not Agree, but Science Says You're Attracted to Body Odor

Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Alex Marson (00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools (00:05:56) Immune System, Innate vs Adaptive Immune System (00:10:55) Thymus, T Cell Selection; B Cells & Antibodies (00:13:23) Sponsors: BetterHelp & Helix Sleep (00:16:11) Immune System Health, Sleep, Diet; Genes (00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions (00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics (00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight (00:38:27) BRAC Mutations, Mutagens, Pesticides (00:42:33) Sponsor: AG1 (00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye (00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy (00:59:04) CRISPR, Immunotherapies (01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet (01:08:27) CRISPR Discovery & Mechanism (01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution (01:20:57) Sponsor: LMNT (01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention (01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines (01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine (01:47:51) Sponsor: Function (01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets (01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity (02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience (02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function (02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming (02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices