Podcasts about Mechanism

The Mind-at-Large Project is a three-year, multidisciplinary initiative exploring consciousness and its role in reality. Mind-at-Large seeks to expand this paradigm - investigating the mind's presence across scales, from quantum systems and living organisms to ecosystems and the cosmos itself. This series examines ideas such as panpsychism, pantheism, idealism, 4E cognition, animism, perspectivism, and non-human intelligence, while also engaging with extraordinary phenomenologies found in psychedelic experiences, mystical states, and anomalous consciousness.TIMESTAMPS:(00:00) – Introduction: The Mind-at-Large Project – Consciousness Beyond the Brain(02:30) – Setting the Stage: Bridging Science, Philosophy & Mysticism(06:10) – What Does “Mind-at-Large” Mean? Context from Bergson, James & Whitehead(10:25) – Peter on Philosophy's Role: Expanding Mind Beyond Materialism(14:02) – Matt on Process Philosophy: Cosmos as a Living Mind(18:35) – Psychedelics, Panpsychism & the Renewal of Consciousness Studies(23:15) – The Crisis of Materialism: Why Science Needs a Broader Ontology(28:20) – Reconciling Science & Spirituality Without Dogma(33:40) – Whitehead's Influence: From Process to Participation(39:15) – Consciousness as Cosmos: The Participatory Universe(43:45) – Bergson's "Élan Vital" and the Evolution of Experience(47:52) – Peter on Nietzsche, Bergson & Psychedelic Metaphysics(53:00) – Matt on Cosmotheology: The Universe as an Ongoing Creation(58:24) – Ethics of Expanding Consciousness: Individual & Cosmic Implications(1:03:12) – Philosophy's Function Today: Meaning in an Age of Mechanism(1:07:40) – The Role of Psychedelics in Re-enchanting the World(1:13:02) – Toward an Integrative Science of Mind-at-Large(1:18:26) – Panpsychism vs. Idealism: Mapping the Metaphysical Terrain(1:23:58) – Matt on Whitehead's Process Metaphysics & Ecology of Mind(1:29:47) – Peter on Nietzsche's Eternal Return & Mind as Becoming(1:34:25) – The Future of Consciousness Studies: Interdisciplinary Frontiers(1:40:10) – Mind-at-Large Conferences: Mission, Vision & Collaboration(1:46:28) – Closing Reflections: Consciousness, Cosmos & Human MeaningEPISODE LINKS:- Mind-at-Large Project: https://mindatlargeproject.com- Peter's Website: https://www.philosopher.eu- Peter's YouTube: https://youtube.com/@Ontologistics- Peter's X: https://twitter.com/PeterSjostedtH- Peter's LinkedIn: https://uk.linkedin.com/in/dr-peter-sjöstedt-hughes-2b7a2927- Peter's Podcast: https://youtu.be/t6FZ5AB5998?si=RUNsQLyRMJQR9HXW- Peter's Lecture: https://www.youtube.com/watch?v=f4yCrqS0dCY- Matt's Website: https://footnotes2plato.com- Matt's YouTube: https://youtube.com/@footnotes2plato- Matt's Podcast: https://www.youtube.com/watch?v=9Vgskuk6Ef0- Matt's Lecture: https://youtu.be/XGulaiHDheY?si=bsZU-ohYTmhjTQJ6- Matt's X: https://x.com/ThouArtThat- Matt's LinkedIn: https://www.linkedin.com/in/matthewdavidsegallCONNECT:- Website: https://mindbodysolution.org- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- YouTube: https://youtube.com/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Featuring an interview with Dr Ghayas Issa, including the following topics: Mechanism of action and efficacy of menin inhibitors (0:00) Presentation and management of differentiation syndrome (13:31) Role of menin inhibitors in other cancers (18:19) Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51) Mechanisms of resistance to menin inhibition in AML (26:53) Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31) Mechanism of action of menin inhibitors as differentiation agents (38:05) Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55) Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25) Other investigational therapeutic strategies in AML (54:39) CME information and select publications

Wastewater isn't an endpoint—it's a decision point. On Wastewater Thursday, host Trace Blackmore, CWT sharpens the operator's toolkit with field-tested lessons: dose by mechanism, verify by sampling discipline, and use wastewater's fast feedback to protect quality, cost, and permits. Sampling discipline protects credibility Trace recounts an early-career moment when an inspector sampled the wrong location, triggering alarms. Immediate, methodical resampling—guided by logs and a clear process map—proved the system was in spec. The leadership takeaway: embed verification before escalation. Clear sampling points, time-stamped logs, and a rapid “reproduce the reading” drill turn uncertainty into clarity.  Mechanism over myth: coagulant control  In a new Detective H2O case, James McDonald explains why overfeeding coagulant collapses floc. When particles swing past neutral, like charges repel again and settling stalls. The fix is not “more chemistry,” but right-sizing dose to production and confirming with jar tests at the correct take-off point.  From discharge to resource  Greetings from past guests reinforce the shift under way. Arnaud Valleteau de Moulliac (Veolia Water Technology) frames wastewater as a local, decarbonized resource—with energy-positive plants and reuse as standard practice. Steve Russell (Kiewit) notes supply pressure will push even deeper recycling. Mark Lewis, CWT (Southeastern Laboratories) underscores wastewater's advantage: “If you treat it, you see it.”  Make wastewater a reliable, fast-feedback control loop—rooted in charge balance, sampling rigor, and reuse thinking.  Listen to the full conversation above. Explore related episodes below. Stay engaged, keep learning, and continue scaling up your knowledge!    Timestamps:  02:17 — Welcome to Wastewater Thursday and the IWW25 theme: “From foundations to futures.” 03:03 — Why wastewater is “the restart”: cleaning for reuse and sustainability. 04:24 — “Every drop counts from influent to effluent” — defining the professional mandate. 05:12 — Field story setup: jar testing with Trace's father; early lessons. 06:05 — Crisis call: bad regulatory number traced to wrong sampling location. 08:54 — Guest greeting: Arnaud Valleteau de Moulliac (Veolia) on energy-positive, reuse-driven futures. 10:25 — Guest greeting: Steve Russell (Kiewit) on permits, mass balances, and supply-driven recycling. 12:09 — Guest greeting: Mark Lewis, CWT (Southeastern Laboratories) on jar tests and product selection. 14:40 — Detective H2O: The case of too much of a good thing 20:17 — Mechanism lesson: charge neutralization window; like-charge repulsion returns when overdosed. 21:36 — Action: reduce dose; account for residence time; restore performance. 24:29 — IWW25 community prompt: post a safety-approved photo with wastewater equipment; use tags.   Connect with Mark Lewis   Phone: 704.322.5406   Email: MLewis@SELaboratories.com    Website: https://www.selaboratories.com/    LinkedIn: linkedin.com/in/mark-lewis-01a3b56    Connect with Steve Russell   Phone: 913.689.4533  Email: steve.russell@kiewit.com  Website: https://www.kiewit.com/  LinkedIn: https://www.linkedin.com/in/steve-russell-2b0a7960/    Connect with Arnaud Valleteau de Moulliac   Email: arnaud.valleteau@veolia.com Website: www.veoliawatertechnologies.com LinkedIn: linkedin.com/in/arnaud-valleteau-de-moulliac-9b85353a/   www.linkedin.com/company/veolia-water-technologies/    Links Mentioned  AWT (Association of Water Technologies)  Scaling UP! H2O Academy video courses  Submit a Show Idea  The Rising Tide Mastermind  031 The One with Mark Lewis  034 The Other One With Mark Lewis, CWT  112 The One Where Trace Is Interviewed By Mark Lewis  141 The One About Neglected Accounts  149 The One About Some of the Lesser-Used Technologies  382 Leading with Safety: How Veolia Embeds Health into Global Culture  396 Navigating Carbon Capture: Water Demands and Wastewater Solutions with Steve Russell  404 Eight Tips for Business Management: Part 1 – Essential Strategies  406 Eight Tips for Business Management: Part 2 – Essential Strategies 

Welcome to the Social-Engineer Podcast: The Doctor Is In Series – where we will discuss understandings and developments in the field of psychology.   In today's episode, Chris and Dr. Abbie explore the intriguing phenomena of dreams, the placebo effect, and déjà vu. They delve into the mysteries of why dreams can feel more emotionally intense than reality, how belief can trigger real physiological changes, and the perplexing sensation of déjà vu that leaves us questioning our memories. Through engaging discussions, they uncover what science knows and the many questions that remain unanswered about these fascinating topics. [Oct 6, 2025]   00:00 - Intro 00:54 - Dr. Abbie Maroño Intro 01:14 - Intro Links -          Social-Engineer.com - http://www.social-engineer.com/ -          Managed Voice Phishing - https://www.social-engineer.com/services/vishing-service/ -          Managed Email Phishing - https://www.social-engineer.com/services/se-phishing-service/ -          Adversarial Simulations - https://www.social-engineer.com/services/social-engineering-penetration-test/ -          Social-Engineer channel on SLACK - https://social-engineering-hq.slack.com/ssb -          CLUTCH - http://www.pro-rock.com/ -          innocentlivesfoundation.org - http://www.innocentlivesfoundation.org/                                 03:17 - The Topic of the Day: Dreams, Placebo and Deja Vu 04:11 - Why Do We Dream? 07:01 - Information Integration 09:36 - Second-Hand Emotion 11:41 - What We Don't Know 14:28 - Uploading Your Dreams 17:26 - The Placebo Effect 22:57 - Context Dependent 26:09 - Non-Responders 28:21 - Deja Vu 30:01 - The Smell Trigger 31:31 - The Emotional Aspect 34:43 - What's Your Sign? 35:44 - Wrap Up 35:59 - Next Month: Ambition    36:34 - Outro -          www.social-engineer.com -          www.innocentlivesfoundation.org   Find us online: -          LinkedIn: linkedin.com/in/dr-abbie-maroño-phd -          Instagram: @DoctorAbbieofficial -          LinkedIn: linkedin.com/in/christopherhadnagy     References: Barrett, D. (2001). The committee of sleep: How artists, scientists, and athletes use dreams for creative problem solving—and how you can too. Oneiroi Press.   de la Fuente-Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001). Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease. Science, 293(5532), 1164–1166. https://doi.org/10.1126/science.1060937   Hobson, J. A. (2009). REM sleep and dreaming: Towards a theory of protoconsciousness. Nature Reviews Neuroscience, 10(11), 803–813. https://doi.org/10.1038/nrn2716 Hobson, J. A., & McCarley, R. W. (1977). The brain as a dream state generator: An activation-synthesis hypothesis of the dream process. Cognitive Psychology, 5(4), 448–502. https://doi.org/10.1016/0010-0285(77)90005-9   Platek, S. M., Critton, S. R., Myers, T. E., & Gallup, G. G. (2003). Contagious yawning: The role of self-awareness and mental state attribution. Cognitive Brain Research, 17(2), 223–227. https://doi.org/10.1016/S0926-6410(03)00109-5   Revonsuo, A. (2000). The reinterpretation of dreams: An evolutionary hypothesis of the function of dreaming. Consciousness and Cognition, 9(2), 210–218. https://doi.org/10.1006/ccog.2000.0422   Stickgold, R., & Walker, M. P. (2013). Sleep-dependent memory triage: Evolving generalization through selective processing. Trends in Cognitive Sciences, 17(10), 501–507. https://doi.org/10.1016/j.tics.2013.06.003   Voss, U., Holzmann, R., Tuin, I., & Hobson, J. A. (2009). Lucid dreaming: A state of consciousness with features of both waking and non-lucid dreaming. Sleep, 32(9), 1191–1200. https://doi.org/10.1093/sleep/32.9.1191   Wager, T. D., Scott, D. J., & Zubieta, J.-K. (2007). Placebo effects on human μ-opioid activity during pain. NeuroImage, 35(1), 253–264. https://doi.org/10.1016/j.neuroimage.2006.11.026

This week we're joined by Adele Houghton of the Harvard School of Public Health and Carlos Castillo-Salgado of the Johns Hopkins Bloomberg School of Public Health to discuss their new book Architectural Epidemiology: Architecture as a Mechanism for Designing a Healthier, More Sustainable, and Resilient World. We chat about how to connect the social and architectural determinants of health before projects get off the ground in order to create more healthy neighborhoods. +++ Get the show ad free on Patreon! Follow us on Bluesky, Threads, Instagram, YouTube, Flickr, Substack ... @theoverheadwire Follow us on Mastadon theoverheadwire@sfba.social Support the show on Patreon http://patreon.com/theoverheadwire Buy books on our Bookshop.org Affiliate site!  And get our Cars are Cholesterol shirt at Tee-Public! And everything else at http://theoverheadwire.com

SUMMARY In this episode of Vibe Science, Ryan Alford interviews Dr. Paramesh Gopi, co-founder of Sound Health. Dr. Paramesh Gopi shares his journey from tech entrepreneur to doctor, and discusses the development of the Sono Band—a wearable device using AI-powered, personalized sound and vibration therapy to clear nasal congestion and improve sleep. The episode covers clinical results, FDA clearance, and new research on sleep improvement, as well as upcoming products and applications in airway health. Listeners learn how innovative technology is transforming wellness through better breathing, sleep, and overall performance.   TAKEAWAYS Personal health journey of Dr. Paramesh Gopi and its impact on his work. Development of Sound Health and the Sono Band wearable device. Use of AI and machine learning to create personalized sound and vibration therapy. Mechanism of action: how sound and vibration clear nasal congestion. Clinical evidence supporting the effectiveness of the Sono Band. FDA clearance process and clinical trials for the device. Broader applications of the technology for sleep improvement and overall wellness. Future product developments, including a focus on sleep and airway health. Importance of non-invasive, drug-free alternatives for treating nasal congestion and related issues. Interconnectedness of breathing, sleeping, and overall health performance. This episode is sponsored by: Warrior Salt Electrolyte Powder – Hydrate & Reenergize Naturally Experience Warrior Salt's all-natural electrolyte powder for optimal hydration and performance. Boost energy, prevent cramps, and stay hydrated. Order Now!  

A Japanese research team has unraveled the Venus flytrap's detailed mechanism to detect insects using its touch sensor.

Effects of Social Isolation and Loneliness on the Heart   Guest: Amir Lerman, M.D. Host: Stephen L. Kopecky, M.D.   Social isolation and loneliness are common, mainly in the elderly, and are regarded as major cardiovascular risk factors. The factors are associated with an increase in cardiovascular events and mortality. Additionally, social isolation and loneliness are associated with increased systemic inflammation and progression of atherosclerosis   Topics Discussed: How do you identify social isolation? Mechanism of social isolation and loneliness on CV health Prevalences and risk of social isolation and loneliness Findings of a recent study from Mayo Clinic Case story: the Roseto effect Potential therapy    Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

What if context—patient beliefs, provider expectations, and the therapeutic relationship—drives a meaningful share of spinal manipulation outcomes? In this HANDS ON HANDS OFF episode, we break down a single-arm intervention study funded by the Paris Family Foundation via the Foundation for OMPT, why the current mechanisms model zeroes in on the “context zone,” and how to practically weave guidelines + shared decision-making into outpatient practice.Top takeawaysOutcomes vary—and context might be part of the mechanismStudy design links individual providers ↔ individual patients for cleaner signalsImplementation: use shared decision-making to operationalize guidelinesCareer notes: pick mentors early, build long-term collaborators, include patient partners

rWotD Episode 3069: Castes in India: Their Mechanism, Genesis and Development Welcome to random Wiki of the Day, your journey through Wikipedia's vast and varied content, one random article at a time.The random article for Sunday, 28 September 2025, is Castes in India: Their Mechanism, Genesis and Development.Castes in India: Their Mechanism, Genesis and Development was a paper read by B. R. Ambedkar at an anthropological seminar of Alexander Goldenweiser in New York on 9 May 1916. It was later published in volume XLVI of Indian Antiquary in May 1917. In the same year, Ambedkar was awarded a PhD degree by Columbia University on this topic. In 1979, the Education Department of the Government of Maharashtra (Bombay) published this article in the collection of Ambedkar's writings and speeches Volume 1; later, it was translated in many languages.In the paper, Ambedkar made a presentation a social phenomenon that emerged from the strategy of the Brahmins who adopted a strictly endogamous matrimonial regime, leading the other groups to do the same in order to emulate this self-proclaimed elite. He said that "the superposition of endogamy on exogamy means the creation of caste".This recording reflects the Wikipedia text as of 00:15 UTC on Sunday, 28 September 2025.For the full current version of the article, see Castes in India: Their Mechanism, Genesis and Development on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Bluesky at @wikioftheday.com.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm standard Kendra.

Shai Wyborski is one of the three co-authors of the GHOSTDAG paper, and a man who takes pride in his independent thinking and divergent approach to research. As a PhD in quantum cryptography, he's got lots of knowledge to share. But by virtue of his involvement in Bitcoin and Kaspa, he's got stories to tell too. What does the future of Proof of Work look like? Let's find out! Time stamps: 00:01:09 - Welcoming Shai Wyborski 00:01:28 - Dig into GhostDAG; most interesting PoW scaling tech. 00:04:44 - Shai's BTC opinions over time 00:05:21 - How Shai spent BTC on "creativity fuel" (undisclosed). 00:06:31 - Disenchantment: Steam drops BTC (congestion/volatility); SegWit "tyranny" births BCH. 00:10:47 - Rejects SoV; BTC as "decentralized vault" for eternal data archiving. 00:15:44 - BTC probs: Low TPS; LN fails. 00:16:15 - Kaspa suite: Beyond TPS/confirmations. 00:16:59 - Tradeoff: High throughput → no audit; pruning for 10-30yr trust. 00:18:40 - GhostDAG multi-ledger: Parallel processing, flexible tx order. 00:19:45 - Miners: Partial info cuts selfish mining/MEV. 00:20:42 - Enables auctions/oracles (Elliot Mabe block-voting). 00:21:40 - Debunks PoW myths: BTC artifacts (congestion for fees). 00:22:15 - Kaspa: Paradigm shift proof; lessons from protocols. 00:23:24 - Flaw: Fast emission + fair launch = whale buyout. 00:23:49 - Fair ≠ community; coercion w/o social contract. 00:25:10 - Whales fund → control; monetary world nature. 00:27:46 - Balance: Incentives, explicit contracts. 00:30:31 - Mining phases: CPU/GPU/ASIC stages; ultra-ASIC decen lock. 00:32:22 - ASIC-friendly: Cheap/low-power scale. 00:32:47 - Emission: Heavy early; ASICs 80-90% pre-retail. 00:34:29 - Full supply lifetime; tail short?00:35:28 - BTC emission extend 2-4x for social good. 00:37:27 - Kaspa whales: 3 hold 6% ($100M), foundation collusion. 00:38:27 - Kaspa emission: 60% in 1.5yrs emulates BTC adjusted for fast adoption. 00:41:16 - Guitar jam & sponsors.SideShift.ai: KYC-free swaps. NoOnes.com: P2P global south, "lions" mission. Bitcoin.com News: global views. LayerTwo Labs: Drivechains, ETH/Zcash sides. 00:46:49 - Kaspa drivechain?; WBTC custody risks. 00:48:33 - Citrea: ZK-rollup BTC DeFi. 00:49:27 - Alts: Quai grant, Kadena parallels. 00:50:47 - Parallel sec dilution. 00:52:03 - Quai: Selfish mining fixes, Monero 28% vuln. 00:53:01 - Monero RandomX ASIC-hostility. 00:54:02 - PoW specialized non-wasteful. 01:00:00 - Myths: Scalable, non-congested, decentralization. 01:15:00 - Casino stifles ingenuity; hype vs depth (IOTA rush). 01:30:00 - Funding: Retail quick vs VC long (Mobileye 20yr $80B). 01:45:00 - Game theory: Mechanism design incentives. 02:00:00 - Kaspa risks: Whale control, docs issues. 07:00:00 - Music: Beatles Sgt. Pepper post-Pet Sounds. 07:15:00 - McCartney bass; prog Floyd/Crimson.07:30:00 - Pet Sounds "God Only Knows" acapella. 07:43:02 - Pop→exp; Helter Skelter metal. 07:45:36 - Metal thrash/extreme; stoner Pantheon I. 07:47:41 - HS Pantera/prog/funk.07:49:51 - Concerts: Aristocrats, AC/DC; Dylan regret. 07:52:39 - Misses: Jethro Tull/Motörhead; Bon Jovi meh. 07:55:16 - Grunge: Nirvana In Utero, Soundgarden. 07:58:11 - Smashing Pumpkins trilogy; Corgan drama. 08:00:00 - Timeless tees; Doors sloppy; Zep Moby Dick. 08:02:40 - Zappa Inca Roads/Stink-Foot. 08:07:19 - AI scans/drones; govt bans. 08:12:08 - Radical: Vault, SoV, ultra-ASIC. 08:14:02 - PoW scalable/non-wasteful.08:15:00 - Fair vs community; casino timing punish. 08:17:40 - Narratives over fundamentals; retail vs VC. 08:21:07 - Record 8h21m+; ramble praise. 08:21:50 - Q&A: Kaspa 10yr alive, adapt. 08:22:24 - Beatles Kaspa? Pruning no. 08:23:44 - Game theory mechanism design. 08:26:09 - Work: Consulting, patents, Tectonic quantum.08:29:23 - Quai edu grant, freelance. 08:31:17 - KAS +3% pump; past dumps. 08:31:58 - Quai minor pump; negative effects. 08:33:34 - First interview 0.15→0.5¢; 13 KAS dons. 08:34:21 - Jam: Theme rock, lag. 08:38:07 8h39m record! Sponsors recap. 08:40:00 - Next interview with Val Venis on Monero/WWF; banter.

When they design mechanical systems, engineers first need to understand how they will behave using mathematical modelling tools that can simulate their movements. In recent years, they have increasingly explored the possibilities of ‘compliant' mechanisms: highly flexible systems which are now being applied across numerous leading fields of technology. However, because their motions are often incredibly complex, engineers have so far found it difficult to recreate their behaviours in the mathematical tools needed to design them. Because they involve complex, nonlinear behaviour, designing compliant mechanisms has posed a long-standing challenge for engineers. While several advanced synthesis methods are now available, they're often computationally intensive and can't readily cope with the inevitable uncertainties in a system's operating variables. In their latest research, Ahmed Alhindi and Dr. Meng-Sang Chew at Lehigh University, Pennsylvania, propose a novel approach that directly accounts for uncertainty in the design process. By reformulating widely used equations, their ‘dimensional synthesis' method offers a streamlined yet powerful way to design compliant mechanisms under real-world, uncertain conditions.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you've heard ATX-304 described as “exercise in a capsule,” you'll see why after going through the research, mechanisms, human trials, and potential applications.I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.

In today's episode, we will conclude Chapter 5 on the Mechanism of Subluxation by discussing Compensation.  This was a revolutionary idea in Dr Gonstead's time, and the Gonstead system is still one of the only technique systems to address the presence of compensation.  This episode is crucial for learning how to distinguish between subluxation and compensation. 

Failure Mechanism Awareness Abstract Kirk and Fred discuss the many different failure mechanisms and the need for understanding the failure mechanisms and causes of failures. Key Points Join Kirk and Fred as they discuss why it is necessary to have an understanding of material science and the physics of failure mechanisms to do a thorough […] The post SOR 1107 Failure Mechanism Awareness appeared first on Accendo Reliability.

Lauren Ross is a professor of logic and philosophy at the University of California, Irvine. We talk about her work on causation, mechanism, and explanation in neuroscience, Lauren's background in medicine, how to write clearly, and much more.BJKS Podcast is a podcast about neuroscience, psychology, and anything vaguely related, hosted by Benjamin James Kuper-Smith.Support the show: https://geni.us/bjks-patreonTimestamps0:00:00: Why Lauren studied medicine0:04:23: Differences between medicine and philosophy0:21:19: Why Lauren switched to philosophy of science0:25:30: How to learn to write clearly0:30:21: Are doctors practitioners of causality?0:34:25: What's so difficult about causality?0:38:46: Causal structures: mechanism, pathway, cascade, circuit.1:02:11: The practical use of thinking about causal structures and varieties1:11:35: What's the difference between a circuit and a pathway? And what are you trying to do?1:20:31: Secondary features of causation/causal varieties: strength, stability, speed, specificity1:29:29: A book or paper more people should read1:30:45: Something Lauren wishes she'd learnt sooner1:33:29: Advice for PhD students/postdocsPodcast linksWebsite: https://geni.us/bjks-podBlueSky: https://geni.us/pod-bskyLauren's linksWebsite: https://geni.us/ross-webGoogle Scholar: https://geni.us/ross-scholarBlueSky: https://geni.us/ross-bskyBen's linksWebsite: https://geni.us/bjks-webGoogle Scholar: https://geni.us/bjks-scholarBlueSky: https://geni.us/bjks-bskyReferencesAlon (2006). An introduction to systems biology: design principles of biological circuits. [There's a lecture series by Alon that seems to be based on the book: https://www.youtube.com/watch?v=N6VZeWuME_A&list=PLLbr-B8cNbo6v4kc68JowzUeAYdh6gdQH]Barack, Miller, Moore, Packer, Pessoa, Ross, & Rust (2022). A call for more clarity around causality in neuroscience. Trends in neurosciences.Forsyth (2013). The elements of eloquence: How to turn the perfect English phrase.Hempel (1965). Aspects of scientific explanation.Ross (2021). Causal concepts in biology: How pathways differ from mechanisms and why it matters. The British Journal for the Philosophy of Science.Ross & Bassett (2024). Causation in neuroscience: keeping mechanism meaningful. Nature Reviews Neuroscience.

The Government of National Unity - GNU - Clearing House Mechanism concluded a crucial meeting YESTERDAY during which it got submissions from the Good Party, Al Jama-Ah, and Democratic Alliance. The GNU Clearing House Mechanism is meant to resolve policy disagreements within the 10-member Government of National Unity, and is chaired by Deputy President Paul Mashatile. Bongiwe Zwane spoke to Keith Khoza, Acting Spokesperson to the Deputy President

Send us a textIn today's episode of PTs Snacks podcast, hosted by Kasey, we dive into the intricacies of high ankle sprains, also known as syndesmotic ankle sprains. We'll explore the relevant anatomy, common mechanisms of injury, diagnostic techniques, and treatment strategies. Kasey also highlights the importance of distinguishing high ankle sprains from other types of ankle injuries and discusses both non-surgical and surgical management approaches. Whether you're a seasoned physical therapist or a student, this episode is packed with valuable insights to enhance your clinical practice.00:00 Introduction to PTs Snacks Podcast00:19 Understanding High Ankle Sprains00:56 Anatomy Review: Syndesmotic Ligaments03:43 Mechanism of Injury05:29 Clinical Presentation and Diagnosis06:43 Stress Tests for High Ankle Sprains08:29 Imaging and Differential Diagnoses09:30 Treatment and Rehabilitation Stages11:43 Prognosis and Final Thoughts12:19 Special Offers and ConclusionGo to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Make sure to hit follow now so you don't miss an episode! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. You can also join the email list HERE Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less! Prepping for the NPTE? Get all the study tools you need to master it at PT Final Exam. Use code PTSnacks at checkout to get a discount! Want to Support the Show?Help me keep creating free content by: Sharing the podcast with someone who'd benefit. Contributing directly via the link...

There's a new development project planned for the intersection of Holmes and Pleasant Grove in Southwest Lansing. This project is unique as it provides a creative investment opportunity for citizens. Joining Chris to share the vision and the strategy for the Holmes & Pleasant Grove project are members of the Lansing Growth Fund, Brent Forsberg and Chris Miller!

Show host Gene Tunny breaks down why price controls are one of the most consistently failed economic policies. Using vivid historical examples from the 1970s US, the Soviet Union's command economy, and Venezuela's toilet paper crisis, he illustrates how interfering with the price mechanism leads to shortages, inefficiency, and unintended consequences. Gene would love to hear your thoughts on this episode. You can email him via contact@economicsexplored.com.TimestampsIntroduction to the Podcast and Episode Theme (0:00)Price Controls and Their Economic Implications (2:47)President Nixon's Wage and Price Controls (8:53)The Soviet Union's Central Planning System (18:20)Economic Inefficiency in the Soviet Steel Industry (29:24)Venezuela's Toilet Paper Crisis (31:57)TakeawaysPrice controls disrupt vital economic signals, leading to misallocation of resources and market inefficiency.Nixon's wage and price freeze in the 1970s led to empty supermarket shelves, black markets, and farmers slaughtering livestock to cut their losses.Soviet central planning failed due to the absence of price signals, leading to constant shortages—even of basic goods like meat and bread.Venezuela's price caps on essentials like toilet paper created massive shortages and forced the government to import millions of rolls.The price mechanism acts as a societal dashboard, helping balance supply and demand more efficiently than central planning or rationing.Links relevant to the conversationBen Bernanke's book – 21st Century Monetary Policyhttps://www.amazon.com.au/21st-Century-Monetary-Policy-Inflation/dp/1324020466BBC News Article on Venezuela's Toilet Paper Crisis: "Venezuela aims to end toilet paper shortage"https://www.bbc.com/news/business-22621833Bread and Autocracy: Food, Politics, and Security in Putin's Russiahttps://www.amazon.com.au/Bread-Autocracy-Politics-Security-Putins/dp/019768436XStephen Kotkin – Armageddon Averted: The Soviet Collapse 1970–2000https://www.amazon.com.au/Armageddon-Averted-Soviet-Collapse-1970-2000/dp/0195368630Friedrich Hayek – “The Use of Knowledge in Society”https://www.econlib.org/library/Essays/hykKnw.htmlLumo Coffee promotion10% of Lumo Coffee's Seriously Healthy Organic Coffee.Website: https://www.lumocoffee.com/10EXPLOREDPromo code: 10EXPLORED 

Melvin Lim from PropertyLimBrothers explores the concept of the Equity Triangle and the core mechanism he calls the Triple Movement of real estate: broad-based inflation, asset inflation, and debt erosion. Through the story of Andrew and Z, a couple who scaled their portfolio from an $800K HDB to $4.6M in residential assets, Melvin illustrates how disciplined reinvestment, understanding seasons of investment, and healthy leverage can change the trajectory of one's financial future.   He breaks down how recognising life's seasons—summer for growth, winter for divestment—can guide strategic property decisions. Hear real examples of how inflation affects both property value and loan value over time. Learn how to structure your holdings for lasting flexibility and eventual passive income. For anyone navigating real estate strategy from age 25 to 65, this episode is not to be missed!   0:00 - Intro 1:29 - Building your Equity Triangle 1:43 - Real Estate Appreciation Triple Movement 3:05 - Inflation 3:37 - Asset Inflation 4:52 - Leverage 6:39 -  10:13 - Case Study: Andrew & Ziyi 13:00 - Growing into a $4 Million Portfolio 14:57 - Protected Savings 15:42 - Winter Season Route 16:13 - Capital Appreciation based on inflation 17:05 - Funnel of Passive Income 19:19 - Mechanism of the Equity Triangle 20:29 - Acceleration of Asset 21:21 - Compound Interest Building 22:22 - How you can still enjoy 23:49 - Outro

Joe's Premium Subscription: www.standardgrain.comGrain Markets and Other Stuff Links-Apple PodcastsSpotifyTikTokYouTubeFutures and options trading involves risk of loss and is not suitable for everyone.0:00 Ag Economy6:57 Soybean Hit Piece9:58 SREs11:15 Grain Standards Act12:13 Cattle Selloff14:03 BLS Data (Jobs)

On today's episode: A common drug taken for heart conditions might not be as useful as we thought. How much energy does it take to get ChatGPT to help cook dinner tonight? All that and more today on All Around Science...RESOURCES https://www.sciencedaily.com/releases/2025/08/250831010539.htm What is a beta blocker? Mechanism of action. How beta blockers help the heart to work.Explained: Generative AI's environmental impact | MIT NewsAI's Growing Carbon FootprintCREDITS:Writing - Bobby Frankenberger & Maura ArmstrongBooking - September McCrady THEME MUSIC by Andrew Allenhttps://twitter.com/KEYSwithSOULhttp://andrewallenmusic.com Hosted on Acast. See acast.com/privacy for more information.

In today's episode, we begin our exploration of Chapter 5 on the Mechanism of Vertebral Subluxation.   We will begin by looking at the normal structure and function of the intervertebral disc and how it works in the ideal situation.  

John Batchelor 09-03 segment 15.mp3 Guest: Janatyn Sayeh from the Foundation for Defense of Democracies. Iran's Nuclear Dilemma and Regional Threats Janatyn Sayeh discusses the looming snapback mechanism of the 2015 JCPOA, which could reinstate UN sanctions on Iran if it fails to comply with demands. Iran's non-compliance has its currency hitting new lows, yet Tehran threatens regional war and exiting the NPT if sanctions return. Sayeh notes Iran seeks rearmament, primarily from China, with Belarus and North Korea acting as potential intermediaries for Russian weapons. 1852 TEHRAN

We get deep with the Wistful Bard himself Ray Flanagan as he shares the lessons and perspectives he's gained over 11 years as a full-time musician.Ray is deeply woven into Cleveland's music community. Catch him hosting jam nights every Tuesday at Mercury Music Lounge, or see his collaboration sets the last Monday of the month at The Winchester.His new album "My Mind is Burning Up" drops next spring, but you can get early access by DMing him for a private link. In the meantime, dive into his extensive discography on all streaming platforms. THANK YOU RAY.SONGS PERFORMED:Someone Else's ShoesI Love the NighttimeAshesWe're DoomedSimple Stuff I GuessPerformance mixed/mastered by Jake ConderCONNECT WITH RAY:https://www.instagram.com/rayaflanagan/https://rayflanagan.bandcamp.com/music----...if you have a sec - please leave us a rating/ review on Apple/ Spotify!Apple: https://podcasts.apple.com/us/podcast/locle-grown/id1619510885Spotify: https://open.spotify.com/show/6OpyraRZDUqf6h8ZKq8KE3?si=75f15ec563714a6cApply to be a guest: https://www.loclegrown.com/past-guests-and-how-to-apply Circle K is a proud sponsor of LoCLE Grown! Download the Inner Circle App today to get .25 cents per gallon off your first 5 fill ups and 5 free drinks! Learn more here: https://www.circlek.com/inner-circleCircle K Inner Circle iPhone App: https://apps.apple.com/us/app/circle-k/id1592397814Circle K Inner Circle  Google Play App: https://play.google.com/store/apps/details?id=com.circlek.gmap.na&hl=en&gl=US&pli=1

Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers exercise as a treatment for depression. Our guest for this episode is Dr. Nicholas Fabiano, a third-year psychiatry resident at the University of Ottawa. His research focuses on the overlap between mental and physical health, particularly lifestyle measures that can be used to improve mental health, including exercise, diet, and sleep.The learning objectives for this episode are as follows:Understand the evidence supporting the antidepressant effects of exercise Explore the mechanisms underlying the benefits of exerciseLearn how to prescribe exercise as a treatment for depressionIdentify the risks and caveats of prescribing exercise for depressionGuest: Dr. Nicholas Fabiano (PGY3)Hosts: Dr. Wendy MacMillan-Wang (PGY4) and Dr. Angad Singh (PGY1)Audio Editing: Dr. Angad Singh (PGY1)Timestamps:(2:55) Origins of the interest in exercise(6:22) Evidence of antidepressant effects(14:05) Considerations in special populations(18:00) Overlap of mental and physical health(20:37) Mechanism of action(26:18) Exercise prescription(33:10) Exercise as addiction and self-harm(36:42) Counselling and mitigating harm(39:30) Combining with other lifestyle interventions(41:41) Evidence for other mental illnessesReferences:Fabiano N, Gupta A, Fiedorowicz JG, Firth J, Stubbs B, Vancampfort D, Schuch FB, Carr LJ, Solmi M. The effect of exercise on suicidal ideation and behaviors: A systematic review and meta-analysis of randomized controlled trials. Journal of affective disorders. 2023 Jun 1;330:355-66.Fabiano, N., Puder, D., & Stubbs, B. (2024). The evidence is clear, exercise is not better than antidepressants or therapy: it is crucial to communicate science honestly. Journal of Physical Activity and Health, 1(aop), 1-2.Heissel, A., Heinen, D., Brokmeier, L. L., Skarabis, N., Kangas, M., Vancampfort, D., ... & Schuch, F. (2023). Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression. British journal of sports medicine, 57(16), 1049-1057.Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024). From movement to motivation: a proposed framework to understand the antidepressant effect of exercise. Translational Psychiatry, 14(1), 273.Verhoeven, J. E., Han, L. K., Lever-van Milligen, B. A., Hu, M. X., Révész, D., Hoogendoorn, A. W., ... & Penninx, B. W. (2023). Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders. Journal of affective disorders, 329, 19-29.For more PsychEd, follow us on Instagram (@psyched.podcast),  Facebook (PsychEd Podcast), X (@psychedpodcast), and Bluesky (@psychedpodcast.bsky.social‬). You can email us at psychedpodcast@gmail.com and visit our website at psychedpodcast.org.

In this episode, Dr. Jockers takes a deep dive into the shocking truth about Ozempic and other GLP-1 weight loss drugs. You'll hear how these medications actually work in the body, why they cause rapid weight loss for some, and what doctors often leave out about their risks. The discussion is packed with insights you won't want to miss.   You'll also learn about the real side effects—ranging from digestive distress to more dangerous issues like thyroid cancer and kidney failure—that affect nearly one in five people taking these drugs. Dr. Jockers breaks down the science in plain language so you can make informed choices.   And if you're wondering whether there's a safer way to get the same results, you'll discover how protein, fiber, and healthy fats can mimic the appetite-regulating effects of Ozempic. These lifestyle strategies not only reduce cravings but also improve long-term health without the side effects.     In This Episode:  00:00 Introduction to Weight Loss Study 00:27 Welcome and Episode Overview 01:00 Exploring GLP-1 Agonists 03:51 Deep Dive into Weight Loss Medications 04:33 Mechanism of GLP-1 Drugs 09:21 Clinical Research Findings 12:30 Side Effects and Risks 14:08 Natural Alternatives to Medications 17:53 Conclusion and Final Thoughts     Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com/DRJ.     “Ozempic lowers blood sugar, but it may also raise your risk of thyroid cancer, pancreatitis, and kidney failure.”  ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: GetLymphHelp.com/jockers Visit https://renewyourhair.com/drj   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

What if telepathy isn't fantasy, but an undiscovered frontier of biophysics? In this conversation, Helené Wahbeh of the Institute of Noetic Sciences joins us to explore how mind-to-mind communication could be studied through neuroscience, quantum theory, and consciousness research. We're not obsessed with whether it's real — we're asking how it would work if it were. A tightrope the edge of what's known, where psi phenomena meets mechanism and physics.PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showOUR HOMEBREWED MUSIC Check out our band's new album:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-hereVinyl pre-orders available now: https://buy.stripe.com/14A5kC3Od5d21Ms7zPdEs09Follow Helenê & IONS at https://noetic.org00:00 Go! Intro to Psi Phenomena 00:05:00 Media Influence on Psi Research 00:06:12 Dr. Wahbeh's Journey into Psi Research 00:19:00 Historical Context of Channeling Practices 00:24:54 Medicalization and Altered States 00:26:04 Spirit Influence on Mental Health 00:29:27 Historical Context of Spiritualism 00:32:56 Power and Intermediaries in Religion 00:35:12 Personal Experiences with Spirituality 00:39:50 The Nature of Prophecy and Free Will 00:42:00 Interpretation and Influence of Messages 00:47:30 Interconnectedness and Source of Information 00:49:33 Physics vs. Spiritual Experience 00:50:14 Importance of Rigorous Evidence in Telepathy Studies 00:53:37 Controlled Studies vs. Anecdotal Evidence 00:56:43 Challenges of Proving Paranormal Phenomena 00:59:38 Scientific Validity of Psychic Abilities 01:05:04 Emotional Context in Psychic Experiences 01:11:10 Practical Applications and Future of Psychic Research 01:13:21 Exploring Mechanisms of Telepathy 01:21:04 Instrumentalization of Mental Phenomena 01:32:04 Psychokinesis and Random Number Generators 01:36:52 Non-Physical Mechanisms of Interaction 01:37:40 Exploring Physical vs. Non-Physical Mechanisms 01:42:00 Philosophical Debate on Mechanism and Consciousness 01:49:30 Future of Mechanistic Understanding 01:58:30 Imagining Intentionality in Interconnected Fields 02:01:56 Exploring Consciousness Models 02:05:50 Interconnectedness and Humility in Understanding 02:09:43 Transcendent Experiences and Science 02:13:21 Physics and Mysticism: Distinct Yet Connected 02:22:00 Music, Emotion, and Scientific Inquiry 02:25:11 Exploring Diverse Worldviews 02:27:08 Speculating on Telepathy's Impact 02:31:43 Navigating Uncertainty and Truth 02:34:03 Embracing Collaboration for Future Insights#Consciousness, #Telepathy, #TheoreticalPhysics, #QuantumBiology, #neuroscience , #psi , #mindsciences , #NoeticSciences, #consciousness , #brainpower , #psychicenergy, #bigquestions #philosophypodcast , #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities.

In this episode of Nuggets On The Go, Melvin from PropertyLimBrothers presents a strategic update on the evolving Singapore property market, focusing on the shift into a sellers market from 2025 to 2027. As interest rates begin to trend downward, Melvin explains why a low interest rate environment will favour asset appreciation and increase buyer demand—ultimately strengthening the position of property owners. He also cautions against premature refinancing, predicting even lower rates ahead.   Learn how Melvin's NSA (Next Stronger Asset) framework can help buyers and investors reposition wisely by upgrading from weaker to stronger assets. He also touches on the broader economic context—liquidity injections, potential Fed rate cuts, and capital flow from equities and crypto into real estate—painting a detailed picture of upcoming opportunities and risks.   If you're considering switching properties or building a portfolio in the current cycle, this episode offers grounded perspectives and timely strategy. An essential listen for those working through timing moves in a shifting market.   0:00 - Intro 0:48 - Episode Outline 0:53 - Important News in September 1:27 - Mechanism for interest rate reduction 2:04 - What Happens When There's Injection of Money Supply in the Market? 2:19 - M2 Money Supply 3:17 - Interest Rate Cuts Forecast 4:26 - Identifying Seller's Market 6:00 - Identifying Buyer's Market 6:36 - How To Switch Your Property in a Seller's Market? 8:19 - Explaining Next Stronger Asset 9:41 - What To Do When Moving to the Next Stronger Asset? 10:42 - What Might Happen to the Equities Market 11:33 - Rates Cuts Relative to Property Price Index 12:31 - Will New Cooling Measures Be Introduced? 13:23 - Some Charts For You 15:27 - Should I Be Worried About the Market Movements? 16:50 - Final Thoughts

Vilazodone (brand name Viibryd) is an antidepressant with a unique pharmacologic profile compared to most other agents in the SSRI class. While not a first-line choice for every patient, understanding its mechanism, adverse effects, and interaction profile is essential for optimizing therapy and preventing downstream prescribing problems. Mechanism of ActionVilazodone is classified as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at the 5-HT1A receptor. The SSRI activity increases synaptic serotonin by blocking the serotonin transporter, while partial agonism at 5-HT1A receptors may contribute to antidepressant effects and potentially reduce certain SSRI-associated adverse effects (though clinical evidence for this benefit is mixed). Adverse Effects GI effects – diarrhea, nausea, and vomiting are frequent early in therapy. Taking the medication with food can help minimize these. Insomnia – often dose-related; morning dosing may help. Sexual dysfunction – may be slightly lower than with some SSRIs but still present. Serotonin syndrome – rare but serious, particularly if combined with other serotonergic drugs. Discontinuation syndrome – abrupt cessation can lead to dizziness, irritability, and flu-like symptoms. Drug InteractionsVilazodone is primarily metabolized by CYP3A4. This means: CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) can increase vilazodone concentrations, potentially worsening side effects—dose reductions may be required. CYP3A4 inducers (e.g., carbamazepine, rifampin, St. John's Wort) can lower drug levels, reducing effectiveness. Other serotonergic agents (e.g., triptans, SNRIs, MAOIs, tramadol, linezolid) increase the risk of serotonin syndrome. Antiplatelets and anticoagulants – SSRIs can impair platelet aggregation, increasing bleeding risk when combined with aspirin, NSAIDs, or warfarin. Prescribing Cascade ExamplesVilazodone's adverse effects can easily lead to unnecessary prescriptions if side effects aren't recognized: GI upset → Acid suppression therapy – Diarrhea or nausea prompts the addition of proton pump inhibitors or antiemetics, instead of adjusting vilazodone dose or timing. Insomnia → Hypnotic initiation – Trouble sleeping results in adding zolpidem or trazodone, without reassessing morning dosing or vilazodone's role. Sexual dysfunction → PDE5 inhibitor prescription – Erectile dysfunction leads to sildenafil use, when the root cause is vilazodone's serotonergic activity. Vilazodone's combination of SSRI and 5-HT1A partial agonist activity makes it somewhat distinct, but its side effect profile and interactions require the same careful monitoring as other antidepressants. Healthcare professionals can play a key role in catching early signs of adverse effects, preventing prescribing cascades, and ensuring drug–drug interactions are managed appropriately.

Your life runs on an invisible engine: your self-image. In this deep dive into Maxwell Maltz's New Psycho-Cybernetics, we uncover how your brain can't tell the difference between real and imagined, why failure is just feedback, and how visualization hijacks your nervous system to create success—or sabotage it.From childhood coding to perfectionism, scars that reshape identity, and the hidden hypnosis we're all still living in, this breakdown reveals how to reprogram the mental mechanism driving your reality.By the end, you'll know how to engineer happiness, free yourself from destructive patterns, and tap into the same internal system that athletes, creators, and high achievers use to perform at their peak.This isn't motivation. It's mental engineering.

Hey now, Cabalists! The gang is back and fired up for another episode of The Cabal! Tony's dealing with his dog's unfortunate bout of diarrhea, Chris went out to see Weird Al, and the crew hit the table with a pile of great new games including Above and Below Haunted, Ark Nova: Marine Worlds, El Burro, Heat Pedal to the Metal, Moon Colony Bloodbath, and feature Shackleton Base by Fabio Lopiano and Nestore Mangone, published by Sorry We Are French. After Tony T delivers his always-popular News segment, the gang dives into a discussion on the vital connection between theme and mechanisms in board games. Above and Below Haunted: 00:09:41, Ark Nova: Marine Worlds: 00:18:15, El Burro: 00:27:16, Heat: 00:37:35, Moon Colony Bloodbath: 00:46:319, Shackleton Base: 01:04:09, News with Tony T: 01:38:04, Theme and Mechanism Alignment: 02:31:41. Check out our sponsors Restoration Games at https://restorationgames.com/. Game Toppers at https://www.gametoppersllc.com/. And Game Night Picks at http://gamenightpicks.com/cabal.

In this episode of the Oncology Brothers podcast, Drs. Rohit & Rahul Gosain welcome Dr. Jacob Sands, a thoracic medical oncologist from the Dana-Farber Cancer Institute, to discuss the recent FDA approval of Dato-DXD (datopotamab deruxtecan) for previously treated EGFR-mutated non-small cell lung cancer (NSCLC). Key Topics: •⁠  ⁠Overview of Dato-DXd and its FDA approval •⁠  ⁠Mechanism of action and study design of the TROPION Lung trials •⁠  ⁠Efficacy and safety profile of Dato-DXd •⁠  ⁠Management of side effects and clinical pearls •⁠  ⁠Treatment sequencing for EGFR-mutated NSCLC Join us as we dive into the details of the TROPION Lung trials that led to this significant approval, the mechanism of action of Dato-DXd, and the implications for patients with various EGFR mutations.  Dr. Sands shared insights on the study design, efficacy, and tolerability of this new antibody-drug conjugate, as well as important clinical pearls for managing side effects such as stomatitis, dry eyes, and interstitial lung disease (ILD). We also explored the current treatment landscape for EGFR-mutated NSCLC, including the sequencing of therapies and the potential role of Dato-DXd in clinical practice. Tune in for an informative discussion that highlights the exciting advancements in oncology and the hope they bring to patients. Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Don't forget to like, subscribe, and check out our other episodes for more insights into the world of oncology!

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Solifenacin is a bladder antimuscarinic medication most commonly used for overactive bladder (OAB) with symptoms of urinary frequency, urgency, and urge incontinence. Like other agents in its class, understanding the pharmacology can help anticipate potential side effects, drug interactions, and downstream prescribing problems. Mechanism of Action Solifenacin selectively blocks muscarinic M3 receptors in the bladder detrusor muscle. Inhibiting these receptors reduces involuntary bladder contractions, increases bladder capacity, and delays the urge to void. While M3 selectivity may theoretically reduce side effects compared to nonselective antimuscarinics, in clinical practice, many anticholinergic effects still occur. Adverse Effects Because muscarinic receptors are present throughout the body, solifenacin can lead to a range of anticholinergic adverse effects: Dry mouth – among the most common, can be significant enough to cause dental issues with long-term use. Constipation – especially problematic in older adults; severe cases may require hospitalization. Blurred vision – due to impaired accommodation. Cognitive impairment – increased risk in older adults, particularly with cumulative anticholinergic burden. Urinary retention – paradoxical worsening in patients with bladder outlet obstruction. Drug Interactions CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) can increase solifenacin plasma concentrations, raising the risk of side effects. Other anticholinergics (e.g., diphenhydramine, tricyclic antidepressants, other bladder antimuscarinics) can result in additive toxicity and higher anticholinergic burden. QT-prolonging drugs (e.g., amiodarone, certain fluoroquinolones) may have additive cardiac risk since solifenacin has been associated with QT prolongation in rare cases. Prescribing Cascade Examples Constipation → Laxative initiation – A patient starts solifenacin for OAB and develops severe constipation, leading to chronic use of stimulant laxatives like senna or bisacodyl. Dry mouth → Mouth rinse prescription – Dry mouth is treated with saliva substitutes or prescription rinses, instead of reassessing the anticholinergic therapy. Cognitive decline → Donepezil initiation – In older adults, cognitive impairment may be mistaken for dementia progression, leading to cholinesterase inhibitor prescribing—directly counteracting the anticholinergic effects of solifenacin. Solifenacin can be an effective treatment for OAB, but the risk of adverse effects and prescribing cascades—especially in older adults—cannot be ignored. Healthcare professionals should regularly review the indication, monitor for anticholinergic burden, and look for opportunities to deprescribe when appropriate.

We Got This With Mark and Hal determines the best door opening mechanism of all time. This decision is legally binding.

PEEPanEIP - EIP-7892: Blob Parameter Only Hardforks PEEPanEIP - EIP-7892: Blob Parameter Only Hardforks In this episode, Pooja Ranjan discusses EIP 7892 with Mark Mackey, exploring its implications for Ethereum's scalability and the innovative approach to managing blob capacity. They delve into the technical aspects of the proposal, the importance of community involvement, and the future of Ethereum upgrades. Mark shares insights from his journey as a client developer and emphasizes the collaborative nature of the Ethereum community.

Watch hol+ by Dr. Taz MD on YouTube: https://www.youtube.com/@DrTazMD/podcastsAre you looking to proactively address metabolic disruptions and create a healthier lifestyle? In this episode of hol+, Dr. Taz MD explores the pressing issue of metabolic health and the economic burden of metabolic diseases, which cost around $427 billion annually. Dr. Taz addresses the common misconceptions about metabolic health, emphasizing that it encompasses more than just weight management. The episode delves into the mechanisms of GLP-1 medications, their effects, and the holistic strategies required to manage metabolic health effectively. By addressing inflammation, hormonal imbalances, and gut health, Dr. Taz provides a comprehensive guide to improving metabolic health for individuals and families alike. Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Stay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Host & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)05:30 The Financial Burden of Metabolic Disease08:19 Mechanism and Impact of GLP-1 Medications16:19 Diagnosing Metabolic Disease25:52 Medications: Finding the Right Balance29:17 Understanding Inflammation and Its Impact33:44 Hormones and Metabolic Health37:00 The Role of Gut Health in Metabolism39:11 Environmental Toxins and Metabolic Disease41:48 Building a Holistic Metabolic Plan44:44 Final Thoughts and Practical Steps

Melissa and Jam explore the science behind why sweat is salty. They discuss personal experiences with sweating, the types of sweat glands, and the chemical processes involved in sweat production. The episode explains how osmosis, ion channels, and salt concentrations contribute to the movement of sweat through sweat glands to the skin's surface. They also touch on evolutionary aspects and the role of sweat in cooling the body. For anyone curious about the chemistry of everyday life, this episode offers an accessible and intriguing explanation. 00:00 Introduction: Why is Sweat Salty? 00:27 Personal Experiences with Sweat 01:32 The Science Behind Sweat 02:00 Meet the Hosts 02:20 Types of Sweat Glands 04:30 How Sweat Reaches the Skin 07:31 The Role of Salt in Sweat 14:20 Health Indicators in Sweat 17:01 Understanding Osmosis and Interstitial Fluid 17:39 Evolutionary Perspective on Sweating 20:01 Mechanism of Sweat Glands 22:41 Sweat Composition and Function 27:39 Personal Sweating Experiences 33:47 Supporting the Show and Community ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife References from this episode: https://pmc.ncbi.nlm.nih.gov/articles/PMC6773238/ https://pubs.rsc.org/en/content/articlehtml/2024/lc/d3lc00874f#cit23 https://pubs.acs.org/doi/full/10.1021/acsnano.4c10344 Thanks to our monthly supporters Vince W Julie S. Heather R Autoclave Chelsea M Dorien VD Scott B Jessie R Ciara L J0HNTR0Y Jeannette N Cullyn R Erica B Elizabeth P Sarah M Rachel R Letila Katrina B Suzanne P Venus R Lyn S Jacob T Brian K Emerson W Kristina G Timothy P Steven B Chris and Claire S Chelsea B Avishai B Hunter R ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife

It's no secret that humans are conditioned to look for the negative.    The constant battle against negativity rages every single day.    Print.    TV.    Social media.    We can't get through our days without some negative news trying to penetrate our mentality.    What happens when we're faced with negativity is our brains are positioned to fight or flight.    But, what if there was a way to break out of this.    There is a way, and it takes focus, consistency, and practice.    And it's possible to do it easily.    The first thing you have to do is correct the trigger when you want to dive into the same stream of negativity the world brings you.    If someone wants to argue, find a way to diffuse it, no matter who is right or wrong.    When someone comes in and throws things into chaos, don't accept it as a problem you need to solve.    In moments of great stress,  and negativity, motivate yourself with love, gratitude, and abundance.    When you rewire your mind against its nature, you can operate from a place of love.    It's going to take some work, but when you do, watch the world you create change right in front of your face.    Most of the things we worry about never come to fruition.    Follow the path of inpenetrable positivity and let life flow.    About the ReWire Podcast   The ReWire Podcast with Ryan Stewman – Dive into powerful insights as Ryan Stewman, the HardCore Closer, breaks down mental barriers and shares actionable steps to rewire your thoughts. Each episode is a fast-paced journey designed to reshape your mindset, align your actions, and guide you toward becoming the best version of yourself. Join in for a daily dose of real talk that empowers you to embrace change and unlock your full potential.    Learn how you can become a member of a powerful community consistently rewiring itself for success at https://www.jointheapex.com/   Rise Above

Recorded with a live audience in Cambridge, this captivating conversation delves deep into the life and career of a cultural force of the last half-century. Known of course for his iconic role as Baldrick in Blackadder, Sir Tony's sharp intelligence and dry humour have had a formative influence on generations.  In this candid discussion, he opens up about the unexpected turns and profound challenges that have shaped his extraordinary journey as an actor, presenter, documentary maker and writer. You'll hear his deeply personal reflections on fatherhood, insights into the creative process behind his recently announced novel, and the powerful lessons learned from a lifetime of experiences, both public and private.  Prepare for an engaging, wise, and moving conversation that explores the transformative power of vulnerability and the importance of finding meaningful connection. This is a unique opportunity to hear a national treasure like never before. ✨ IN THIS EPISODE: 00:00 Intro 00:45 Tony Robinson's Early Life and Career 03:13 Fatherhood and Family 04:55 Writing and Publishing a Novel 10:50 The Impact of Blackadder 13:16 Challenges and Conflicts in Blackadder 16:33 Height and Personal Insecurities 20:42 Childhood and Adolescence Struggles 22:41 Growing Up in the Shadow of WWII 24:49 The Ups and Downs of Gambling 27:28 Early Career and Poker Lessons 29:29 Child Actor Earnings and Capitalism 34:23 Dealing with Alzheimer's in the Family 37:03 Reflecting on Personal Failures 44:56 Finding Meaningful Relationships

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Join us as we dive deep into pectoralis major tears. We'll discuss the anatomy of the pectoralis major, typical mechanisms of injury, and examination methods to diagnose these tears accurately. We also cover risk factors, differential diagnosis, and imaging options. Finally, we'll talk about treatment plans, both conservative and surgical, and the importance of understanding tissue healing timelines. 00:00 Introduction to the Podcast and Today's Topic01:18 Anatomy of the Pectoral Major02:10 Mechanism of Injury and Common Symptoms03:53 Assessment and Diagnosis06:38 Imaging and Differential Diagnosis07:31 Treatment Options: Conservative vs. Surgical08:44 Post-Surgical Rehabilitation Phases11:00 Key Takeaways and ConclusionSupport the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq: Get 10% off with code PTSNACKS10: [Tindeq] ...

Rachelle Robinett, founder of Pharmakon Supernatural and educator in holistic health, offers a clear, science-aware framework for supporting energy, focus, and stress regulation, without defaulting to pharmaceuticals or overstimulation. In this episode, she explores how plant-based medicine, nutrition, and daily practices can be woven into practical, long-term routines that support resilience and cognitive clarity.   Robinett challenges the assumption that performance must rely on synthetic energy or end in burnout. Drawing from her work at the intersection of herbalism and evidence-based wellness, she shares actionable strategies for optimizing physiological readiness through balance, not intensity.   “I'm really interested in how we can live well without needing to biohack or rely on pharmaceuticals or stimulants or even supplementation all the time.”   Key insights from the conversation include: Stimulants Borrow, Not Create Energy Robinett explains that caffeine and similar compounds don't give us energy; they “just turn off the signals of fatigue.” Instead, she emphasizes rhythm management, aligning with circadian patterns and energy cycles: “You don't have to be on all the time. And if we try to be, the crash will always come.”   Herbs Should Be Matched to Mechanism, Not Trend She encourages listeners to move beyond marketing labels like “adaptogen,” noting that compounds like rhodiola (stimulating) and reishi (sedating) serve very different roles.  “Match your plants to your goals... It's kind of like caffeine; if you don't need it, don't take it.”   Sugar Is Energizing, But Often Disruptive Robinett discusses how sugar can be paired with fiber, fat, or protein to reduce its volatility: “Sugar is biologically energizing… but we tend to use it in ways that give us a spike and then a crash.”   Daily Practices Outperform Sporadic Interventions Light exposure, meal timing, and breathwork help regulate the autonomic nervous system more effectively than isolated hacks: “What we do daily matters more than what we do occasionally… so many people don't understand how profoundly their breathing patterns are affecting their state.”   Recovery Is an Active Recalibration Robinett distinguishes between activities that feel restful and those that actually reset the stress response system: “Sometimes the things we think are relaxing are not—Netflix, alcohol, even yoga. True recovery is shifting the nervous system.”   This conversation reframes wellness not as indulgence or optimization, but as physiological literacy—a disciplined, systems-level approach to mental clarity and endurance. For professionals seeking alternatives to overstimulation, Robinett offers a sustainable path toward long-term resilience and regulated energy.   Get Rachelle's book here: https://shorturl.at/q7TDb Naturally: The Herbalist's Guide to Health and Transformation   Here are some free gifts for you: Overall Approach Used in Well-Managed Strategy Studies free download: www.firmsconsulting.com/OverallApproach   McKinsey & BCG winning resume free download: www.firmsconsulting.com/resumepdf   Enjoying this episode? Get access to sample advanced training episodes here: www.firmsconsulting.com/promo

Have you ever wondered what happens when a toddler gets into something they definitely shouldn't? Today, Dr. Monica Gray, Dr. Pradip Kamat, and Dr. Rahul Damania discuss the case of an 18-month-old boy who accidentally ingested concentrated bleach, presenting with stridor, drooling, and vomiting. They review the clinical approach to caustic ingestions in children, including airway management, diagnostic workup, and the roles of endoscopy, steroids, and multidisciplinary care. The episode also highlights potential complications such as esophageal strictures and cancer, emphasizes prevention strategies, and provides key takeaways for intensivists managing similar pediatric emergencies. If you're an intensivist or just want to know what to do in a pediatric emergency, don't miss these essential takeaways for managing one of the scariest situations in the ER.Show Highlights:Case study of an 18-month-old boy who ingested concentrated bleachClinical presentation including symptoms like stridor, drooling, and vomitingManagement strategies for caustic ingestions in childrenImportance of airway management and monitoring in cases of caustic ingestionDiagnostic workup including imaging and endoscopyDifferential diagnosis considerations for similar presentations (e.g., button batteries, laundry detergent pods)Mechanism of injury caused by alkaline substances like bleachLong-term complications associated with caustic ingestions, such as esophageal strictures and cancerMultidisciplinary approach to treatment involving various medical specialtiesPrevention strategies to reduce the incidence of accidental caustic ingestions in childrenReferences:American Academy of Pediatrics – Pediatric Care Online: Esophageal Caustic Injury (AAP clinical guidance on caustic ingestions).Fuhrman & Zimmerman's Pediatric Critical Care textbook – Chapters on toxicology and gastrointestinal emergencies (covering caustic injury management and critical care approach).Hoffman RS, et al. “Ingestion of Caustic Substances.” New England Journal of Medicine. 2020; 382(18):1739-1748. A comprehensive review of caustic ingestion injuries and management.Arnold M, Numanoglu A. “Caustic ingestion in children – a review.” Semin Pediatr Surg. 2017;26(2):95-104. Review of epidemiology, pathophysiology, and treatment of caustic injuries in kids.Johnson CM, Brigger MT. “The public health impact of pediatric caustic ingestion injuries.” Arch Otolaryngol Head Neck Surg. 2012;138(12):1111-1115. (Epidemiology study showing declining incidence).Pediatric Critical Care Medicine (PCCM) Journal – various case reports and series on caustic ingestion (for case-based insights), and annual National Poison Data System reports (for statistics on pediatric poisonings).Tringali A, et al. ESGE/ESPGHAN Pediatric GI Endoscopy Guidelines (Endoscopy, 2017) – Includes recommendations for endoscopy timing and steroid use in caustic ingestions.Usta M, et al. “High doses of methylprednisolone in the management of caustic esophageal burns.” Pediatrics. 2014;133(6):E1518-24. (Key study demonstrating steroids benefit in grade 2b injuries).Royal Children's Hospital Melbourne – Clinical Practice Guidelines: Caustic Ingestions (2019) – Practical hospital guidelines emphasizing early intubation for airway threat, endoscopy within 24h, IV PPI, and supportive care.

Sarah Kennedy of Calocurb discusses the natural and medical ways to suppress appetite, focusing on the revolutionary GLP-1 agonists (like Ozempic and Wegovy). This is truly a deep dive into the mechanism of GLP-1 and its role in regulating appetite and blood sugar. You will learn all about the innovative Calocurb supplement, founded by Sarah, which uses a patented hops extract to effectively increase GLP-1 and reduce calorie intake by 18%. A must-watch for women in midlife looking to manage their weight naturally.Go to https://calocurb.com/drstephanie to get 10% off your first purchaseEpisode overview (timestamps are approximate):(0:00) Intro/Teaser(7:00) Understanding GLP-1 and Appetite Suppression(24:00) Exploring the Effects of CaloCurb(39:00) Mechanism and Benefits of CaloCurb(43:00) Practical Strategies for Managing Hunger and Stress Eating(54:00) Research and the Future of Natural Appetite Suppression(1:03:00) BONUS: Dr. Stephanie's "After Party"Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep425A huge thanks to our sponsors:BEAM MINERALS - Replenish essential minerals your body needs. Visit https://beamminerals.com/better for 20% off of the entire store. The discount is auto-applied at checkout.LVLUP  - Midlife hormonal changes can wreak havoc on your gut health. Ultimate GI Repair combines powerful gut-healing peptides with gut-nourishing naturals to soothe your changing digestion. Learn more at https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% off.TIMELINE - As perimenopausal women, we know we are in a fight against time to preserve our muscle strength and endurance, plus our recovery needs are greater. That's why you save 20% at https://timelinenutrition.com/better with code BETTER.MAUI NUI VENISON - Packed with essential vitamins, minerals, and bioavailable compounds that support energy, performance, and overall health. Head over to  https://mauinuivenison.com/better to checkout their premium snack sticks and fresh starter boxes.

Fat Loss & Metabolism with Dr. Ben Bikman Challenging the dogma surrounding heart disease. (1:32) Is there a connection between dementia and heart disease? (12:05) Strength training and Alzheimer's. (17:49) Learning something new helps put off dementia. (22:45) The connection between insulin resistance and your body's inability to fight off infection. (25:17) We put TOO much attention on total cholesterol. (27:55) Fat cells dynamics explained. (30:13) Why your metabolism is EXTREMELY complex. (44:14) Mitochondrial uncoupling. (48:51) Ketones and athletic performance. (55:39) The problem with DNP. (58:11) Why he is a HUGE advocate of creatine. (1:01:03) The brain loves ketones. (1:04:33) Keep your running shoes in the closet, GO STRENGTH TRAIN! (1:05:32) The metabolic origins of chronic disease. (1:08:10) How GLP-1s are being overused and the proper way to use them. (1:14:48) The resurgence of religion. (1:37:57) As a scientist, did he ever doubt his faith? (1:41:28) The most profound moment of his life. (1:45:51) Related Links/Products Mentioned Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease - and How to Fight It – Book by Dr. Benjamin Bikman How Not to Get Sick: A Cookbook and Guide to Prevent and Reverse Insulin Resistance, Lose Weight, and Fight Chronic Disease – Book by Dr. Benjamin Bikman Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at https://ketone.com/MINDPUMP June Special: Shredded Summer Bundle or Bikini Bundle 50% off! ** Code JUNE50 at checkout ** Most heart attack patients' cholesterol levels did not indicate cardiac risk Study: Doubling Saturated Fat in the Diet Does Not Increase Saturated Fat in Blood Insulin signal transduction pathway Mind Pump #1922: Fatphobia & Other Lies That Are Keeping You Fat, Unhealthy & Sick Diabulimia: Why This Eating Disorder Is So Dangerous for People with Diabetes Harris-Benedict equation - Wikipedia Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases DNP (Dinitrophenol): Overview, Mechanism, and Risks Mind Pump #2497: The Amazing & Weird Side Effects of Creatine Muscle strength and fitness linked to reduction in cancer deaths Fighting Cancer By Putting Tumor Cells On A Diet - NPR Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined Attenuated GLP-1 secretion in obesity: cause or consequence? Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Liraglutide modulates lipid metabolism via ZBTB20-LPL pathway Mind Pump #872: Dr. Warren Farrell- The Boy Crisis Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Benjamin Bikman (@benbikmanphd) Instagram Website Zach Bitter (@zachbitter) Instagram  Thomas N. Seyfried (@thomasseyfriedbc) Instagram Warren Farrell, PhD (@drwarrenfarrell) X/Twitter  

437: Neal McDonough—Clear the Mechanism The perennial character actor villain turned leading man drops by to talk about the first film where he finally gets to kiss the girl at the end, The Last Rodeo—and that girl is played by his wife, Ruvé. Coincidence? Not a chance. That's the only way Neal would do it. Neal also discusses how he secured a return to Taylor Sheridan's Tulsa Kings, why he thought Sylvester Stallone might deck him on set, and the greatest career advice Clint Eastwood gave him. Today's episode is sponsored by CompanyCam.com Jobsite photo tools to manage work from anywhere. American-Giant.com/MIKE Use code MIKE to get 20% off your order. skillsusa.org/mike Join the skilled trade movement! Watch People You Should Know on Mike's YouTube Channel