Podcasts about Mechanism

In this episode, Roxy returns to the pod to help Julia explore the fascinating history of scent: from ancient Greek perfumers on Aphrodite's island to Abercrombie cologne cloud terrorism. Plus, the girlies explain why smell is uniquely different from all our other senses, the Proustian relationship between scent and memory, and how capitalism has transformed our desire to smell good into a billion dollar identity crisis. Digressions include being flexed on by your parents, a man who generously donated his hair to a horse, and society's collective Mrs. Meyer's trauma. This episode was produced by Julia Hava and Kylie Finnigan and edited by Livi Burdette.  Roxy's Website: https://rjamin.net/ SOURCES 3,200-Year-Old Mesopotamian Perfume Recreated from Ancient Text     A Brief History of Scent  A Cultural Autopsy of the Celebrity Perfume  A Journey Through Time in Fragrance  Abercrombie Employees Have To Spritz Clothes With Cologne Every Hour Alain Corbin The Foul and the Fragrant: Odor and the French Social Imagination Aroma: The Cultural History of Smell  Cleopatra May Have Once Smelled Like This Recreated Perfume  Effects of ambient odors on slot-machine usage in a Las Vegas casino. Fragrant by Mandy Aftel History of the Hero: Chanel No5 How Advertisers Convinced Americans They Smelled Bad  How Coco Chanel changed the course of women's fashion I'm the Perfumer Who Created the Scent You Love to Hate — Abercrombie & Fitch's Fierce   In France's Perfume Capital Of The World, There's A World Of Beautiful Fragrance  Love Stinks: The Association between Body Odors and Romantic Relationship Commitment  Many find the term 'Oriental' offensive. Why are perfumers still using it?  Perfume Culture Is Starting to Stink  PERFUMERY The psychology and biology of fragrancе Psychology of Fragrance Use: Perception of Individual Odor and Perfume Blends Reveals a Mechanism for Idiosyncratic Effects on Fragrance Choice Poor Sense of Smell Linked to Increased Risk of Depression in Older Adults  Tappūtī-Bēlet-ekallim, The Oldest Perfumer on Record The Connections Between Smell, Memory, and Health  The effects of scent on consumer behaviour  The mysterious sense of smell: evolution, historical perspectives, and neurological disorders The Mystery of Ambergris  The proust effect: Scents, food, and nostalgia  The Smell of Evolution The Truth About Pheromones  The Ugly History of Beautiful Things: Perfume This Is What Space Smells Like You don't say? The smell of love You Might Not Agree, but Science Says You're Attracted to Body Odor

Most skincare advice is focused on fixing what you can see—wrinkles, texture, tone. But by the time those changes appear, the underlying biology has already been shifting for years.In this episode of The One Thing Podcast, Dr. Rinde sits down with pharmacist and founder of Atika Wellness , Lily Shapiro, PharmD – to explore a more accurate way to think about skin health—one that moves beyond “anti-aging” and toward what she calls skin span.Lily breaks down the science behind how skin actually ages and why many popular solutions fall short. From the truth about collagen and biotin to the limitations of topical products, this conversation challenges some of the most common assumptions in the skincare world.You'll also learn the four core drivers of skin longevity—collagen integrity, antioxidant balance, lipid barrier function, and mitochondrial health—and how a systems-based approach can support your skin from the inside out.If you're looking for a clearer, more science-backed way to approach your skin and your health, this episode will give you a new framework to work from.—Topics covered:• Why “anti-aging” is the wrong framework• The truth about collagen, biotin, and hyaluronic acid• The CALM framework for skin longevity• How hormones impact skin, especially in midlife• Why most supplements fall short• The connection between internal health and visible skin changes—Follow Dr. Rinde for more conversations focused on the one thing that truly moves your health forward.Show links: https://www.atikawellness.com/About our guest:About Lily Shapiro, PharmDLily Shapiro is a pharmacist and the founder of ATIKA, a nutritional dermatology brand built on scientific clarity, therapeutic dosing, and a commitment to skin longevity. Her work centers on helping women nourish the biological foundations of resilient, healthy skin through evidence-based daily nutrition.During her 40s, Lily began noticing the early signs of collagen decline, dryness, and barrier changes that accompany midlife transitions. What she found in the supplement aisle were under-dosed blends, fragmented routines, and marketing-driven formulations that lacked clinical integrity.As a pharmacist trained in pharmacology, nutrient metabolism, and compounding, she saw an opportunity to bring therapeutic precision into the ingestible beauty space. ATIKA was created to offer one clinically aligned, properly dosed formula supporting the four core pillars of skin health: collagen structure, lipid barrier integrity, antioxidant defense, and cellular renewal.Evidence before trend. Every ingredient is selected based on published human data, not aesthetics or hype.Therapeutic dosing. Clinical outcomes require clinical amounts — not pixie-dust blends or proprietary dilution.Mechanism-first formulation. Collagen synthesis, barrier lipids, oxidative stress, and cellular energy work together; the formula must reflect that integration.Restraint and transparency. No exaggeration, no over-claiming, no clutter — only what is necessary and clinically relevant.Doctor of Pharmacy (PharmD)Clinical background in compounding and women's healthExperience analyzing ingredient pharmacokinetics, nutrient pathways, and therapeutic dosingFounder & Formulator of ATIKA Advanced Skin NutritionHer work reflects a belief that skin longevity begins with foundational biology — collagen structure, barrier lipids, detoxification of oxidative stress, and cellular energy. ATIKA exists to bring these truths to the center of daily ritual.

Featuring an interview with Prof Constantine Tam, including the following topics: Evolving first-line treatment paradigm for patients with previously untreated chronic lymphocytic leukemia (CLL) (0:00) Considerations for the administration of first-line venetoclax-based regimens (3:24) Mechanism of action of sonrotoclax and observed early-phase efficacy in combination with zanubrutinib; minimal residual disease as a potential clinical trial endpoint (10:01) Continuous versus fixed-duration first-line treatment approaches for previously untreated CLL (14:38) Selecting between up-front acalabrutinib- and zanubrutinib-based time-limited therapy options (19:07) Up-front treatment selection for patients with del(17p) CLL (24:01) Stopping and restarting acalabrutinib for frail patients with previously untreated CLL (26:43) Pirtobrutinib for treatment-naïve and relapsed/refractory CLL/small lymphocytic lymphoma: Results from the Phase III BRUIN CLL-314 and BRUIN CLL-313 trials (30:20) Lisocabtagene maraleucel as treatment for patients with double-refractory CLL (37:00) Perspectives on future roles of novel therapies and treatment strategies (43:11) CME information and select publications

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making.⚠️ SIGN UP FOR OUR FREE NEWSLETTER: [NEWSLETTER SIGN-UP]In this episode:How opioids produce analgesia by decreasing synaptic transmission in central pain pathways rather than blocking nerve conduction μ, κ, and δ opioid receptor pharmacology and how Gi-coupled GPCR signaling alters calcium, potassium, and cAMP How opioids reduce pain by suppressing ascending nociceptive signaling and enhancing descending inhibitory pathways The physiologic basis of common opioid effects including respiratory depression, sedation, bradycardia, and GI effects

Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Alex Marson (00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools (00:05:56) Immune System, Innate vs Adaptive Immune System (00:10:55) Thymus, T Cell Selection; B Cells & Antibodies (00:13:23) Sponsors: BetterHelp & Helix Sleep (00:16:11) Immune System Health, Sleep, Diet; Genes (00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions (00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics (00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight (00:38:27) BRAC Mutations, Mutagens, Pesticides (00:42:33) Sponsor: AG1 (00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye (00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy (00:59:04) CRISPR, Immunotherapies (01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet (01:08:27) CRISPR Discovery & Mechanism (01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution (01:20:57) Sponsor: LMNT (01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention (01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines (01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine (01:47:51) Sponsor: Function (01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets (01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity (02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience (02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function (02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming (02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Isaac Hayes III.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Isaac Hayes III.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Isaac Hayes III.

In this groundbreaking episode of the Tick Boot Camp Podcast, we interview Dr. Jayakumar Rajadas, a Stanford Medicine researcher who has discovered multiple breakthrough therapeutic candidates for Lyme disease, Babesia, and Bartonella. His work includes the discovery of Disulfiram's effectiveness against Lyme and Babesia, Azlocillin's potent activity against Lyme and Bartonella, and advanced targeted drug-delivery systems designed to preserve the gut microbiome. Dr. Jay's research has been featured in TIME Magazine (Azlocillin) and Forbes (Disulfiram), and connects deeply with the work of leading Lyme researchers, including Dr. Monica Embers (Tulane), Dr. Kim Lewis (Northeastern), Dr. Kenneth Liegner, and Dr. Brian Fallon (Columbia University). This interview delivers hope, science, and unprecedented detail on what may become the next generation of Lyme disease treatments. Key Topics Covered 1. How the Stanford Tick Initiative Sparked a New Era of Drug Discovery In 2012, Stanford launched a major initiative in response to community demand for better Lyme treatments. Dr. Rajadas was selected to lead drug development, focusing specifically on persistent/chronic Lyme disease, where few researchers were working. 2. Understanding Borrelia: Active vs. Stationary Forms & Why Chronic Lyme Persists Dr. J explains the three key survival modes of Borrelia burgdorferi: Active Phase The bacteria are replicating and metabolically active. Easier to kill with standard antibiotics. Stationary Phase Bacteria reach population limits and slow down growth. Represents early persistence mechanisms. Persister Forms Triggered by stressors like antibiotics (e.g., doxycycline). Bacteria fold into round bodies, spiral forms, or compact “cement-like” protective balls. These forms: Shut down metabolic pathways Resist penetration Survive antibiotic exposure Why Doxycycline Can Fail Doxycycline can induce persisters, causing Borrelia to form impenetrable protective shells rather than die. This is why many patients initially feel better, then relapse. 3. Disulfiram (Antabuse): Lyme + Babesia Breakthrough Featured in Forbes One of the biggest scientific shocks of the last decade: Discovery Through Stanford's high-throughput screening of FDA-approved drugs, Disulfiram emerged as a top hit. Clears Borrelia (including persistent forms) Clears Babesia — a major advantage over standard antibiotics Does NOT harm the gut microbiome Is already FDA-approved and widely used for alcohol aversion therapy Highly potent but requires careful dosing due to side effects in inflamed patients. Why Some Patients Improve, and Others Suffer Chronic Lyme patients already have heightened inflammation. Disulfiram is a powerful molecule whose polymorphic forms behave differently in different people. His lab developed: Less toxic formulations Buccal & sublingual delivery systems Rectal delivery options These may reduce neuropsychiatric side effects reported by some patients. Clinical Connections Dr. Kenneth Liegner pioneered clinical use and published cases Dr. Brian Fallon conducted NIH-listed clinical trials. Many clinicians now use Liegner's protocols. Real-world example: Matt shares the story of Brooke Stoddard (Generation Lyme), who regained his life after Disulfiram treatment under Dr. Liegner. 4. Azlocillin: The Antibiotic That TIME Magazine Called a Gamechanger If Disulfiram is the Lyme and Babesia weapon, Azlocillin may be the frontline tool for Lyme and Bartonella. Why Azlocillin Is Revolutionary Eradicates both active and persister forms of Borrelia. Destroys doxycycline-induced “cement ball” persisters by drilling into their vulnerable cell-wall synthesis pathways. Proven effective against Bartonella when paired with azithromycin, based on research by Dr. Monica Embers (Tulane) . The Cell-Wall Vulnerability Breakthrough Persisters STILL must maintain minimal cell-wall synthesis to survive. Azlocillin exploits this tiny vulnerability: It penetrates the protective sphere Breaks the “cement wall” Forces the bacteria out of hibernation Kills them rapidly This discovery is one of the biggest scientific leaps in Lyme research in a decade. The Delivery System That Protects the Gut Microbiome Azlocillin is extremely hydrophilic, making absorption difficult.Dr. Jay fixed this by creating: A magnesium-lipid nanoparticle formulation Designed to release in the upper intestine Avoiding the colon (where most microbiome lives) This allows: High bloodstream absorption Minimal microbiome damage Oral availability of a drug previously only available via IV Why Azlocillin May Be Better Than Disulfiram Hits Borrelia + Bartonella Stronger anti-inflammatory effects No polymorphism issues Fewer side effects Potent against persisters A company is preparing to bring his oral formulation to clinical trials by next year. 5. Loratadine (Claritin): The First Clue from 2012 Before Disulfiram and Azlocillin, Dr. Jay's lab identified Loratadine (Claritin) as a manganese transporter inhibitor of Borrelia. Why it mattered: Borrelia uniquely relies on manganese, not iron. Blocking manganese uptake may weaken the bacteria. The discovery went viral, with many patients reporting improvement even at OTC doses—though the binding affinity was weak. This project introduced the concept of drug repurposing for Lyme to the scientific community. 6. Melittin (Bee Venom) — The Micro-Needle Patch Alternative Bee venom therapy is widely used in the Lyme community, but risks stings and allergic reactions. Dr. J is developing: Melittin micro-needle patches Delivering the active peptide without stinging Using dissolvable, painless needles A safe, controlled, pharmaceutical-grade delivery approach This could modernize bee venom therapy and make it more accessible. 7. Mechanism of Brain Fog & Fatigue in Lyme: A Major Breakthrough Dr. Jay's lab published a neuroscience paper demonstrating: Outer Surface Protein (Osp) Nanoparticles Borrelia sheds lipid-coated outer membrane particles. These form stable nano-vesicles that: Enter the bloodstream Cross into the brain Cause mitochondrial dysfunction Reduce ATP production Result: Brain Fog, Fatigue, Cognitive Dysfunction This explains why neurological Lyme can persist even after bacterial levels drop. This work ties strongly to ongoing research at Columbia University under Dr. Brian Fallon. 8. Collaborations With World Leaders in Lyme Research Dr. J's research intersects with: Dr. Kim Lewis (Northeastern University) Reproduced and validated Disulfiram findings publicly. Helped launch interest in persister-killing therapies. Dr. Monica Embers (Tulane University) Demonstrated Azlocillin + Azithromycin effectiveness against Bartonella. One of the world's foremost experts in persistent infection models. Dr. Kenneth Liegner Early clinical pioneer of Disulfiram therapy. Published stunning recovery cases. Dr. Brian A. Fallon (Columbia University) Leading psychiatrist specializing in post-treatment Lyme. Conducted planned Disulfiram clinical trials. These collaborations form a powerful network accelerating treatment development. 9. New Anti-Inflammatory Discoveries: Galangin & More Dr. Jay recently co-authored a 2025 paper on: Galangin (Thai ginger rhizome extract) Which may reverse cardiac inflammation and fibrosis His team is also exploring other nutraceutical molecules for chronic inflammation relief in Lyme patients. 10. Dr. Jay's Personal Story of Illness and Hope He reveals for the first time: He was diagnosed with Stage 3 Multiple Myeloma Lost the ability to walk Suffered unbearable pain After cutting-edge therapies and research, he is now in full remission His message to Lyme patients: “There is ALWAYS hope.”

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What if you could drive sales and create real psychological investment in just five days instead of waiting months for high ticket sales?Most businesses are not struggling with visibility, but they are missing a strategic activation mechanism. More content does not automatically mean more revenue. Without a true conversion engine, your audience consumes, nods, and moves on. No urgency, no client conversion.A properly structured five day challenge is designed to build trust, shorten the sales cycle, and create buying momentum quickly. It shifts beliefs in real time, it positions you as the authority, and it moves people from interest to decision.In this episode, you will learn:Why this model works as a strategic sales toolHow to build authority through quick wins that deepen commitmentPractical steps to shorten the sales cycle and accelerate movement toward a buying decisionHow to increase revenue and convert aligned buyers into premium offersThe structure that allows a challenge to create momentum without pressureIf you want a predictable path to client conversion without adding more content, this episode gives you the blueprint.To being heard and seen, CarlyResources from this episode:Therapreneur: A Therapist's Guide to 3x Your Therapy IncomeThe Coach IntensiveReady to Run a Challenge That Actually Converts?Join the 6-Figure Challenge Blueprint Masterclass on March 17, 2026 for just $27, and discover how to turn your next challenge into a premium client pipeline.Listener Giveaway!If you've been loving the podcast, this is the best way to support it and get something amazing back. Visit carlyhillcoaching.com/podcast, scroll down, fill out the 3-question form, and unlock Social Media Mastery instantly.Get 2 FREE months of TherapyNotes and streamline your notes, scheduling, and billing.Use promo code: CarlyExplore More SupportCarly AILooking for more support? Click here to explore different options to work with CarlyWant to start a podcast or grow your existing one? Visit https://julianabarbati.com/ and let them know I sent you!What was your biggest takeaway from this episode? Drop me a DM on Instagram - I'd love to hear from you!“If your audience didn't respond, it's feedback and not rejection.” - Carly Hill

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

Featuring an interview with Dr Hanny Al-Samkari, including the following topics: Mechanism of action and toxicity of the monoclonal antibody ianalumab (0:00) Primary results from VAYHIT2, a randomized, double-blind Phase III trial of ianalumab with eltrombopag for patients with primary immune thrombocytopenia (ITP) after failure of first-line corticosteroid treatment (7:32) Mechanism of action and toxicity of the Bruton tyrosine kinase inhibitor rilzabrutinib (11:52) Reduction in corticosteroid use with rilzabrutinib and sustained response in adults with persistent or chronic ITP in the long-term extension period of the Phase III LUNA3 study (18:46) CME information and select publications

Contributor: Taylor Lynch MD Educational Pearls: Melatonin is an endogenous hormone released primarily by the pineal gland Also released by extrapineal regions in the retina, the GI tract, and some immune cells Peak secretion occurs at night and is suppressed during the day Secretion and production decrease with age Older patients experience the greatest improvement in sleep latency and sleep quality Mechanism of action in the suprachiasmatic nucleus of the hypothalamus MT1 receptor Reduces normal firing MT2 receptor Shifts the circadian rhythm FDA approved for insomnia Decreases sleep latency by 7 minutes Increases total sleep time by 8 minutes FDA approved for circadian sleep-wake disorders Jet lag Most effective in west-to-east travel Best if crossing at least 5 time zones Shift work A study examined ED physicians and nurses with rotating shifts Modest increase in deep sleep percentage No difference in cognition or reaction time the day after taking melatonin Nurses on rotating night shifts experienced increased total sleep time by 20 minutes Dosing 0.5 - 3 mg is the most evidence-based dosing Higher doses increase the risk of rebound grogginess but do not improve outcomes References Ahmad SB, Ali A, Bilal M, et al. Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders. Cell Mol Neurobiol. 2023;43(6):2437-2458. doi:10.1007/s10571-023-01324-w Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520. doi:10.1002/14651858.CD001520 Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, Brown T, Chesson AL Jr, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ, Zak R; Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007 Nov;30(11):1445-59. doi: 10.1093/sleep/30.11.1445. Erratum in: Sleep. 2008 Jul 1;31(7):table of contents. PMID: 18041479; PMCID: PMC2082098. Thottakam BMVJ, Webster NR, Allen L, Columb MO, Galley HF. Melatonin Is a Feasible, Safe, and Acceptable Intervention in Doctors and Nurses Working Nightshifts: The MIDNIGHT Trial. Front Psychiatry. 2020;11:872. Published 2020 Aug 27. doi:10.3389/fpsyt.2020.00872 Summarized and edited by Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf

"Send me a text"Episode Description:Your customer has tried four different supplements for their problem. Every one had a solid mechanism explanation. Every one failed. Now they land on your page, see your mechanism explanation, and think: "This sounds like everything else that didn't work." Hope dies instantly and so does the sale.Hope, one of the four psychological forces that drives supplement purchases, isn't created by explaining mechanisms. Hope is created by explaining why past mechanisms failed and identifying the missing piece that makes this time different.In this episode, we break down why familiar mechanism explanations destroy hope and how to position your supplement as addressing what every other solution missed. You'll learn the difference between explaining your mechanism (which sounds like everything else) and explaining the gap (which creates new possibility).You'll discover:Why "supports relaxation" or "promotes energy" kills sales even when accurateThe two-part Unique Mechanism framework: Why others failed + What was missingHow to identify the gap that creates hope in your specific categoryReal examples of hope-killing vs. hope-creating mechanism explanationsThe missing piece narrative structure that makes customers believe "this time is different"Why this matters more as markets mature and customers have tried more solutionsHow to rewrite your product page to acknowledge past failures before explaining your mechanismIf you have solid science, quality ingredients, and good formulations but your conversion rates are stuck, it's not your product. It's that your mechanism explanation sounds exactly like what already didn't work for them. This episode shows you how to fix it.Hope answers the question: "Why will this time be different?" Familiar mechanisms can't answer that. The missing piece can.Learn more about The Supplement Business Accelerator Group at https://creativethirst.com/group If you're interested in working with me and my team to improve your supplement business. You can learn more at my website https://creativethirst.com Click here to grab your copy of the Health Supplement Ad Swipe Guide. Discover what really works in funnel marketing Need help increasing sales on your own? Click here Stuck at $1 - $5M in revenue? Click Here Case Study on how Creative Thirst added over $200,000 for one supplement brand

In this week's podcast episode in the Nutrition After Breast Cancer: Just the Facts series, I bring up the study that sparked that concern. I don't ignore things like this. I don't pretend they don't exist. If there's research being talked about, I want you to know about it. But here are the actual facts. The study was done in mice. The mice were made to consume about 40% of their diet in olive oil. And the rest of their diet was an obesogenic, high-carbohydrate diet designed to promote weight gain and metabolic dysfunction. That is not a Mediterranean diet. That is not olive oil drizzled over vegetables and salmon. That is not real life. It was a laboratory model designed to stress metabolism. Context matters. Deeply.   Resources Mentioned: Guide to Essential Fatty Acids: https://www.thebreastcancerrecoverycoach.com/oil Episode #326 Simplifying Seed Oils and Fatty Acids After Breast Cancer https://www.thebreastcancerrecoverycoach.com/326   Work with Laura: https://www.thebreastcancerrecoverycoach.com/health      REFERENCES: Obesity and Low-Fat Diet History Trends in Obesity Among Adults in the United States, 2005 to 2014 (CDC) https://www.cdc.gov/mmwr/preview/mmwrhtml/su6001a15.htm Documents obesity prevalence: 15.0% (1976-1980), 23.3% (1988-1994) Adult Obesity Prevalence Maps (CDC) https://pmc.ncbi.nlm.nih.gov/articles/PMC9611578/ 30.9% obesity prevalence (1999-2000) Adult Obesity Prevalence, 2021-2023 (CDC) https://www.cdc.gov/nchs/products/databriefs/db508.htm Current obesity prevalence: 40.3% How the Ideology of Low Fat Conquered America https://pubmed.ncbi.nlm.nih.gov/18296750/ Historical analysis of the low-fat movement Heart Disease Mortality Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000 (Ford et al., NEJM 2007) https://www.nejm.org/doi/full/10.1056/NEJMsa053935 ~51% decline in men, ~49% decline in women 47% from medical treatments, 44% from risk factor changes Obesity and diabetes offset gains by 8% and 10% Heart Disease Mortality in the United States, 1970 to 2022 https://www.ahajournals.org/doi/10.1161/JAHA.124.038644 89% decrease in heart attack deaths 81% increase in heart failure and other heart disease deaths Omega-3s, Inflammation, and Cancer Omega-6/Omega-3 Ratios and Modern Diets Ancestral ratios: 1:1 to 4:1 Modern Western diet: 15:1 to 20:1 Impact on eicosanoid metabolism and cellular inflammation DHA and Triple Negative Breast Cancer (Journal of Nutritional Biochemistry, 2019) DHA induced cell death in TNBC cells Mechanism: altered membrane composition, increased oxidative stress in cancer cells High-Fat Diets and TNBC Metastasis (Preclinical Studies) CD36-mediated fatty acid uptake in TNBC Oleic acid-rich diets promoting metastasis in mouse models Importance of tumor phenotype and metabolic flexibility   Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

For decades, neuroscience treated the brain like a digital machine — storing information in synaptic connections and sustaining activity like a switch flipped on. But what if that model is incomplete?In this conversation, I sit down with Earl Miller, MIT professor and head of the Miller Lab, to explore a growing shift in cognitive neuroscience: the brain may compute using dynamic electrical waves.We discuss how oscillations coordinate millions of neurons, how waves interact with spikes in a two-way system, why large-scale brain organization may depend on rhythmic patterns, and what this means for artificial intelligence.If cognition isn't just stored in connections — but emerges from real-time analog wave computation — how should we rethink intelligence? TIMESTAMPS:(0:00) - Introduction: Mind-Brain Relationship Explained(0:27) - Brain as an Analog System: Dynamic Wave Computation(0:59) - 20th Century Brain Models: Connectionist Cognition(2:04) - AI Limitations from Old Brain Models(2:35) - Storing Information in Synaptic Connections(3:29) - Self-Organizing Brain & Internal Control Systems(4:29) - Brain Waves for Large-Scale Organization(5:17) - Spikes and Waves: Two-Way Brain Interaction(6:30) - Electrical Oscillations: Excitation & Inhibition Patterns(9:30) - Advantages of Wave-Based Processing over Logic Gates(11:00) - Coordinating Millions of Neurons for Attention(12:30) - Goals, Plans & Intentions Driving Brain Activity(15:30) - Real-Time Control: Synapses vs Waves Debate(18:30) - Generating New Brain Wave Patterns in Real Time(23:00) - Implications for AI & Cognitive Science(27:30) - Evolving Views on Cortical Computation & Oscillations(32:00) - High & Low Energy Phases in Brain Waves Explained(38:00) - Waves as a Mechanism for Self-Organization(44:00) - Real Analog Computation Through Wave Interactions(1:15:26) - Closing ThoughtsEPISODE LINKS:- Earl's Website: https://ekmillerlab.mit.edu/earl-miller/- Earl's Publications: https://scholar.google.com/citations?user=hv8jgk8AAAAJ&hl=en- Earl's X: https://x.com/MillerLabMIT- Earl's LinkedIn: https://www.linkedin.com/in/earlkmiller/- Cognition is an emergent property: https://doi.org/10.1016/j.cobeha.2024.101388- Analog Theory:https://loc.closertotruth.com/theory/millers-brain-waves-analog-organization-of-cortex- Cognition Emerges From Neural Dynamics Lecture: https://youtu.be/ie58Ujqy0vACONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

What's really happening inside the larynx when we ‘tilt?' In this episode, Alexa is joined by voice researcher Mathias Aaen to unpack the science behind thyroid tilt - exploring what his latest studies reveal about pitch, vocal fold lengthening, and healthy singing. The pair cut through common misconceptions, translate research into studio-ready language, and ask the big question: are our teaching prompts actually doing what we think they are? If you love practical pedagogy grounded in solid science, this one's for you.  WHAT'S IN THIS PODCAST?  2:58 What is tilt? Anatomy & physiology  6:35 CVT framework 16:13 Study results  22:45 Physiology vs the perceptual  25:36 Teaching prompts  43:10 Vocal fold length and pitch change  48:14 Enemies of tilt 52:37 Common misconceptions about tilt   About the presenter HERE RELEVANT MENTIONS & LINKS Investigating Laryngeal “Tilt” on Same-pitch Phonation—Preliminary Findings of Vocal Mode, Metal and Density Parameters as Alternatives to Cricothyroid-Thyroarytenoid “Mix” by Mathias Aaen et al Correlating Degree of Thyroid Tilt Independent of fo Control as a Mechanism for Phonatory Density with EGG and Acoustic Measures across Loudness Conditions by Mathias Aaen et al Singing Teachers Talk - Ep.131 Mastering Research Papers: How to Read with Ease and Extract Knowledge  Complete Vocal Training  Ian Howell Dr Mark Tempesta Kerrie Obert  Dr Ingo Titze Estill CVT App Folia Phoniatrica et Logopaedica  Manuel Garcia  Praat  ABOUT THE GUEST  Mathias Aaen, PhD, is a voice researcher, educator, and certified rehabilitation specialist. He serves as Honorary Researcher at Nottingham University Hospitals and VP of Research & Collaboration at CVI, and was previously a Fulbright Fellow at UC Berkeley. His work focuses on voice physiology, acoustics, auditory-perceptual analysis, and voice habilitation and rehabilitation, with groundbreaking research into the physiology and health of contemporary commercial music styles, including rock and heavy metal. He recently completed a PostDoc investigating the CVT framework as a clinical treatment for dysphonia in MTD and ABI patients. An award-winning researcher and Authorised CVT Teacher, Mathias is also an active performer who has worked with leading opera houses and voice professionals worldwide.  SEE FULL BIO HEREWebsite

TWiV explains how vaccine-induced thrombotic thrombocytopenia develops from antibodies to adenovirus and somatic hypermutation, and castration by a viral protein tyrosine phosphatase that targets a host cell cycle checkpoint protein. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) US repeals environmental endangerment finding (Nature) Environmental groups sue EPA (Guardian) NIAID to drop pandemic preparedness and biodefense (Nature) FDA backpedals on Moderna mRNA rejection (npr) Mechanism of VITT (NEJM) Parasitc castration by a wasp virus protein (PNAS) Polydnaviruses (PloS Path) Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – The effect of seeing scientists as intellectually humble on trust in scientists and their research Rich – The Great Bridge: The Epic Story of the Building of the Brooklyn Bridge by David McCullough Alan – Recipes from the American South, by Michael Twitty Vincent – Why Returning From Mars ls Impossible – Richard Feynman's Warning Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we explore FDA's plausible mechanism pathway for ultra-rare genetic disorders with Holly Fernandez Lynch, Associate Professor of Medical Ethics at the University of Pennsylvania's Perelman School of Medicine. She discusses how this pathway enables personalized gene therapies for N-of-one or N-of-few diseases while raising important questions about regulatory process, evidence standards, and equitable access. Professor Fernandez Lynch also examines the remarkable case of baby KJ, who received a gene editor to treat his urea cycle disorder, and considers both the transformative potential and the procedural concerns surrounding FDA's approach. 

Featuring perspectives from Dr Natalie S Callander and Dr Paul G Richardson, including the following topics: Introduction: Clinical Trials We LOVE to Discuss (0:00) Mechanism of Action of Cereblon E3 Ligase Modulators (CELMoDs) (8:42) Available Efficacy Data with CELMoDs in the Management of Relapsed/Refractory Multiple Myeloma (MM) (15:59) Extramedullary Disease (19:23) Spectrum and Management of CELMoD-Associated Adverse Events (30:12) Ongoing Phase II and III Trials Evaluating CELMoDs for MM (34:53) CME information and select publications

PREVIEW FOR LATER TODAY Guest: Bob Zimmerman. Zimmerman explains the mechanism behind Saturn'sauroras, describing how material from the moon Enceladus travels along magnetic field lines to the planet's poles.1618

If I asked you at the dinner table what you do as an online fitness coach and you can't tell me with absolute clarity, this episode and your offer is what you should work on right now. When it comes to success with our IFCA clients, when they finally nail their offer and they feel confident about it, everything else starts falling into place.  I'm going to give you some examples of offers I re-wrote for clients recently, how to think about your offer using the Hormozi Value Equation, how you can use our AI software to upgrade your offer, and more!   Time Stamps:   (0:52) Making A Better Offer (2:20) Benefits vs Results (3:26) IFCA Client Examples (6:11) Alex Hormozi's Value Equation (8:26) Selling The Vacation Not The Flight (9:11) The Mechanism (10:57) DM Me "AI Offer" ----------

Some of the biggest advances in women's health start with a simple question: why hasn't this been fixed yet? In this episode of BackTable OBGYN, Dr. Tess Kim, a minimally invasive gynecologic surgeon at Massachusetts General Hospital and the founder of Fruits of Labor, a women's health medical device innovation company, joins host Dr. Amy Park. --- SYNPOSIS Dr. Kim's educational journey began with medical school at Emory, followed by residency at Beth Israel Deaconess Hospital, and fellowship training at MGH. She discusses the founding of Fruits of Labor, which began with the Perry Peach—a warm compress device designed to reduce severe perineal tearing during childbirth and now acquired by Medicines360. Dr. Kim also talks about her creative process, the importance of addressing historically neglected areas in women's health, and the potential impact of her new project, Mellomallows, which aims to reduce discomfort during gynecological procedures such as IUD placement. The conversation concludes with a discussion of the challenges and opportunities in women's health innovation, the significance of supportive networks, and the role of passion and commitment in driving meaningful change. --- TIMESTAMPS 00:00 - Introduction02:03 - The Birth of PeriPeach: Addressing Severe Tearing06:51 - New Medical Devices: Mellomallows08:41 - The Creation and Mechanism of PeriPeach 11:11 - Company Development: Mentorship and Resources17:37 - Pitching Practice and Experience 19:26 - Project Funding and Working with Medicines36021:51 - Advice for Aspiring Innovators23:52 - Concerns About AI in Healthcare26:48 - Innovations in Women's Health29:06 - Challenges in Academic Medicine32:01 - The Importance of Female Innovators34:00 - Forming a Startup in Women's Health36:10 - Parting Advice for Future Innovators37:37 - The Future of Women's Health Innovations40:10 - Conclusion --- RESOURCES Fruits of Labor website:https://www.fruitsoflabormed.com/home PeriPeach website:https://www.peripeach.com/

In this episode, Mike and Molly bridge the gap between the physics of waves and the biology of sensation. The MCAT loves the auditory system because it requires you to integrate knowledge from Physics (wave properties), Biology (structure of the ear and nervous system), and Psychology (signal detection).We take a "bird's ear view" of the auditory pathway, breaking it down into three critical stages:Mechanical Transmission: The outer and middle ear.Transduction: Converting movement into electricity in the inner ear.Neural Transmission: Sending the signal to the brain for interpretation.

Breaking The Silence with Dr Gregory Williams Turning Trauma into Power with Lurata Lyon, Co-Author of a new book titled The Strength of Resilience In this episode of Breaking the Silence, Dr. Gregory Williams interviews Lurata Lyon, author of Unbroken: Surviving Human Trafficking. The conversation explores Lurata's harrowing survival of kidnapping and organ harvesting gangs, her journey of self-healing through writing and fitness, and the profound realization that resilience is not just about bouncing back, but about choosing love over bitterness. Detailed Summary The Philosophy of Brokenness and Resilience Dr. Williams opens with a medical analogy regarding broken bones, noting that during the healing process, a callous forms that temporarily makes the broken site stronger than it was before. This sets the stage for a discussion on trauma. Lurata reflects that despite the horrors she endured, she would not change her past because it forged her current identity. She emphasizes that healing requires a conscious choice to reject the path of self-destruction and instead embrace love, stating she has become "walking love" to ensure the cycle of hate stops with her. Writing as a Mechanism for Healing Lurata shares the origin story of her book, Unbroken. Inspired by the character Carrie Bradshaw in Sex and the City, she began typing her traumatic memories on a laptop simply to mimic the character's routine of "closing the day." This exercise unexpectedly acted as therapy; by externalizing her memories onto a screen, she gained a new perspective—viewing her life as a reader rather than a victim. This process significantly reduced her nightmares and eventually formed the skeleton of her published memoir. Reality of Human Trafficking Lurata details her specific traumatic experiences, including being kidnapped by an organ harvesting gang in Kosovo and later held in solitary confinement for six months by soldiers in Serbia. She describes human trafficking as a "pandemic" and the biggest business in the world, surpassing the drug trade. The conversation touches on modern recruitment tactics, such as bribing parents in war zones (like Ukraine) or luring people with false promises of work, only to strip them of their passports and force them into begging, prostitution, or organ harvesting. Regaining Trust and Taming the "Monster" Recovery for Lurata involved relearning how to trust, starting with her uncle and eventually moving into the fitness industry. She became a successful personal trainer in London by focusing on making clients "feel good" rather than just losing weight. A significant part of her mental recovery was "taming the monster"—the internal rage and defensive aggression she developed to survive. Through mentorship and self-forgiveness, she learned to control her reactions to daily stressors, using breathwork to prevent small problems from triggering survival-mode panic. Future Endeavors Lurata is currently co-authoring a new book titled The Strength of Resilience with an athlete named Fatima, expected to launch in mid-2024. She is also expanding her work into the digital space with online courses on public speaking and mental fitness, and has established a mental health retreat in Marbella, Spain, focusing on hiking, breathwork, and healing. Trauma does not have to define one's future. As Lurata Lyon demonstrates, even the darkest experiences—such as human trafficking and captivity—can be transformed into a source of immense power and purpose. By choosing forgiveness, controlling one's internal narrative, and breaking the silence, victims can transition from surviving to thriving.

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. This episode breaks down what that molecule is, why it works, and how it may upgrade mitochondria, sleep, and human performance when used correctly. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Chris Burres, founder and chief scientist of MyVitalC and the original long-term manufacturer of carbon 60. Chris has produced this Nobel Prize–winning molecule since the early 1990s, supplying research institutions around the world years before it ever entered the biohacking space. He explains how carbon 60 behaves differently from traditional antioxidants, why stability and concentration used to be major problems, and how modern manufacturing finally made real-world use possible. Chris is also a published author, longevity summit host, patent holder, and longtime science communicator who brings rare clarity and humor to complex biology. Dave and Chris explore how carbon 60 interacts with mitochondria, oxidative stress, metabolism, and electrical signaling in the body, and where it fits alongside ketosis, nootropics, supplements, and functional medicine strategies. They also unpack why improving mitochondrial function often shows up first as better energy and sleep optimization, and how that foundation supports longevity, brain optimization, and Smarter Not Harder performance. Along the way, Dave shares his own early experience with C60, how he uses it today, and why it now shows up even in his Danger Coffee stack. You'll Learn: • Why carbon 60 produced the longest longevity result ever recorded in mammal studies • How mitochondrial efficiency shapes energy, sleep, and human performance • What makes C60 a selective antioxidant instead of a blunt one • Why purity, concentration, and stability determine whether a supplement works • How carbon 60 fits into biohacking stacks built around ketosis and metabolism • What users report first, from focus and resilience to deeper sleep • Why mitochondrial health underpins long-term anti-aging strategies • How to think about supplements through a Smarter Not Harder lens Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Affiliates: Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: carbon 60 podcast, C60 longevity science, biohacking mitochondria, mitochondrial optimization podcast, anti-aging supplements science, human performance longevity, selective antioxidant mitochondria, sleep optimization biohacking, brain optimization supplements, nootropics longevity stack, ketosis metabolism longevity, functional medicine mitochondria, oxidative stress longevity, carbon 60 supplement science, MyVitalC podcast, Chris Burres interview, Dave Asprey biohacking, Danger Coffee stack, Smarter Not Harder longevity, Nobel Prize molecule longevity, mitochondrial health podcast Resources: • Get a 30% discount on your next purchase of ESS60 at: https://www.myvitalc.com/pages/humanupgradeod?ref=humanupgrade • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Introduction & C60 Discovery 4:04 – The Molecule & Nobel Prize 8:27 – Quantum Properties & Superconductivity 11:16 – Rat Longevity Study Results 14:33 – Selective Antioxidant Properties 15:51 – User Experience & Timeline 18:15 – Biological Age Testing 21:33 – Why Oil & Product Development 23:32 – Mechanism of Action 28:13 – Biohacker Discovery Story 30:03 – FDA & Supplement Regulation 33:50 – Migraines & Clinical Observations 37:53 – Athletic Performance 40:43 – Stacking & Contraindications 45:57 – Skincare Product 50:43 – Who Benefits Most 1:00:37 – Mitochondria & Consciousness 1:02:03 – Where to Buy & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

An episode discussing the pending gap law, corruption, army spending, rebuilding trust in the banking sector, prospects for Lebanese-Israeli relations and America's diplomatic role at large. With economist and Arab News columnist Nadim Shehadi. Check out Nadim Shehadi's article 'Lebanon is not resilient, it is traumatized': https://www.arabnews.com/node/2144181 and Michael Young's piece 'A Mechanism of Coercion': https://carnegieendowment.org/middle-east/diwan/2026/01/a-mechanism-of-coercion The podcast is only made possible through listener and viewer donations. Please help support The Beirut Banyan by contributing via PayPal: https://www.paypal.me/walkbeirut Or donating through our Patreon page: https://www.patreon.com/thebeirutbanyan Subscribe to our YouTube channel and your preferred audio platform. Follow us on Facebook, Instagram & Twitter: @thebeirutbanyan And check out our website: www.beirutbanyan.com Timestamps: 0:00 Intro 4:36 Protecting the criminals 7:08 Diversion from the real issues 9:05 Gap Law 14:43 Minimizing the state 20:30 Defending unpopular figures 22:18 Corruption in Lebanon 24:24 Investigations 30:38 Constant battering 33:10 Army spending & budget 38:10 Key element is trust 42:23 Discussion on Israel 44:29 Michael Young 46:29 “A Mechanism of Coercion” 51:12 Normalization - an internal matter 1:00:25 American positioning 1:06:07 “We'll just go” 1:13:00 Turning 70

How to turn troubles into liftings

On this week’s episode, we’re continuing our Guidelines Series exploring the 2022 ESC/ERS Guidelines for the diagnosis and treatment of Pulmonary Hypertension. If you missed our first episode in the series, give it a listen to hear about the most recent recommendations regarding Pulmonary Hypertension definitions, screening, and diagnostics. Today, we’re talking about the next steps after diagnosis. Specifically, we’ll be discussing risk stratification, establishing treatment goals, and metrics for re-evaluation. We’ll additionally introduce the mainstays of pharmacologic therapy for Pulmonary Hypertension. Meet Our Co-Hosts Rupali Sood  grew up in Las Vegas, Nevada and made her way over to Baltimore for medical school at Johns Hopkins. She then completed her internal medicine residency training at Massachusetts General Hospital before returning back to Johns Hopkins, where she is currently a pulmonary and critical care medicine fellow. Rupali’s interests include interstitial lung disease, particularly as related to oncologic drugs, and bedside medical education. Tom Di Vitantonio  is originally from New Jersey and attended medical school at Rutgers, New Jersey Medical School in Newark. He then completed his internal medicine residency at Weill Cornell, where he also served as a chief resident. He currently is a pulmonary and critical care medicine fellow at Johns Hopkins, and he’s passionate about caring for critically ill patients, how we approach the management of pulmonary embolism, and also about medical education of trainees to help them be more confident and patient centered. Key Learning Points 1) Episode Roadmap How to set treatment goals, assess symptom burden, and risk-stratify patients with suspected/confirmed pulmonary arterial hypertension (PAH). What tools to use to re-evaluate patients on treatment Intro to major PAH medication classes and how they map to pathways. 2) Case-based diagnostic reasoning Patient: 37-year-old woman with exertional dyspnea, mild edema, abnormal echo, telangiectasias + epistaxis → raises suspicion for HHT (hereditary hemorrhagic telangiectasia) and/or early connective tissue disease. Key reasoning move: start broad (Groups 2–5) and narrow using history/exam/testing. In a young patient without obvious left heart or lung disease, think more about Group 1 PAH (idiopathic/heritable/associated). HHT teaching point: HHT can cause PH in more than one way: More common: high-output PH from AVMs (often hepatic/pulmonary) Rare (1–2% mentioned): true PAH phenotype (vascular remodeling; associated with ALK1 in some patients), behaving like Group 1 PAH. 3) Functional class assessment WHO Functional Class: Class I: no symptoms with ordinary activity, only with exertion Class II: symptoms with ordinary activity Class III: symptoms with less-than-ordinary activity (can't do usual chores/shopping without dyspnea) Class IV: symptoms at rest Practical bedside tip they give: Ask if the patient can walk at their own pace or keep up with a similar-age peer/partner. If not, think Class II (or worse). 4) Risk stratification at diagnosis: why, how, and which tools Big principle: treatment choices are driven by risk, and the goal is to move patients to low-risk quickly. ESC/ERS approach at diagnosis (as described): Use a 3-strata model predicting 1-year mortality: Low: 20% ESC/ERS risk assessment variables (10 domains discussed): Clinical progression, signs of right heart failure, syncope WHO FC Biomarkers (NT-proBNP) Exercise capacity (6MWD) Hemodynamics Imaging (echo; sometimes cardiac MRI) CPET (peak VO₂; VE/VCO₂ slope) They note: even if you don't have everything, the calculator can still be useful with ≥3 variables. REVEAL 2.0: Builds on similar core variables but adds further patient context (demographics, renal function, BP, DLCO, etc.) Case result: both tools put her in intermediate risk (ESC/ERS ~1.6; REVEAL 2.0 score 8), underscoring that mild symptoms can still equal meaningful mortality risk. 5) Treatment goals and follow-up philosophy What they explicitly prioritize: Help patients feel better, live longer, and stay out of the hospital Use risk tools to communicate prognosis and to track improvement Reassess frequently (they mention ~every 3 months early on) until low risk is achieved “Time-to-low-risk” is an important treatment goal Also emphasized: The diagnosis is psychologically heavy; patients need clear counseling, reassurance about the plan, and connection to support groups. 6) Medication classes for the treatment of PAH Nitric oxide–cGMP pathway PDE5 inhibitors: sildenafil, tadalafil Soluble guanylate cyclase stimulator: riociguat Important safety point: don't combine PDE5 inhibitors with riociguat (risk of significant hypotension/hemodynamic effects) Endothelin receptor antagonists (ERAs) “-sentan” drugs: bosentan (less used due to side effects/interactions), ambrisentan, macitentan Teratogenicity emphasized Hepatotoxicity that requires LFT monitoring Can cause fluid retention and peripheral edema Prostacyclin pathway Prostacyclin analogs/agonists: Epoprostenol (potent; short half-life; IV administration) Treprostinil (IV/SubQ/oral/inhaled options) Selexipag (oral prostacyclin receptor agonist) 7) Sotatercept (post-guidelines) They note sotatercept wasn't in 2022 ESC/ERS but is now “a game changer” in practice: Mechanism: ligand trap affecting TGF-β signaling / remodeling biology Positioned as potentially more disease-modifying than pure vasodilators Still evolving: where to place it earlier vs later in regimens is an active question in the field 8) How risk category maps to initial treatment intensity General approach they outline: High risk at diagnosis: parenteral prostacyclin (IV/SubQ) strongly favored, often aggressive early Intermediate risk: at least dual oral therapy (typically PDE5i + ERA); escalate if not achieving low risk Low risk: at least one oral agent; many still use dual oral depending on etiology/trajectory For the case: intermediate-risk → start dual oral therapy (they mention tadalafil + ambrisentan as a typical choice), reassess in ~3 months; add a third agent (e.g., selexipag/prostacyclin pathway) if not low risk.  References and Further Reading Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, Rådegran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022 Oct 11;43(38):3618-3731. doi: 10.1093/eurheartj/ehac237. Erratum in: Eur Heart J. 2023 Apr 17;44(15):1312. doi: 10.1093/eurheartj/ehad005. PMID: 36017548. Condon DF, Nickel NP, Anderson R, Mirza S, de Jesus Perez VA. The 6th World Symposium on Pulmonary Hypertension: what’s old is new. F1000Res. 2019 Jun 19;8:F1000 Faculty Rev-888. doi: 10.12688/f1000research.18811.1. PMID: 31249672; PMCID: PMC6584967. Maron BA. Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer. J Am Heart Assoc. 2023 Apr 18;12(8):e029024. doi: 10.1161/JAHA.122.029024. Epub 2023 Apr 7. PMID: 37026538; PMCID: PMC10227272. Hoeper MM, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, McLaughlin VV, Preston IR, Souza R, Waxman AB, Grünig E, Kopeć G, Meyer G, Olsson KM, Rosenkranz S, Xu Y, Miller B, Fowler M, Butler J, Koglin J, de Oliveira Pena J, Humbert M; STELLAR Trial Investigators. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2023 Apr 20;388(16):1478-1490. doi: 10.1056/NEJMoa2213558. Epub 2023 Mar 6. PMID: 36877098. Ruopp NF, Cockrill BA. Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. JAMA. 2022 Apr 12;327(14):1379-1391. doi: 10.1001/jama.2022.4402. Erratum in: JAMA. 2022 Sep 6;328(9):892. doi: 10.1001/jama.2022.13696. PMID: 35412560.

"A saturated state is a state in which the conceptual or emotional object has absolute value, it is already stacked or closed to new meanings and therefore cannot undergo any kind of transformation. An unsaturated state, on the other hand, is a state in which the emotional or conceptual object is in an open state in which it is still open to transformation, to new meanings, to all kinds of change. What I think is interesting and important is to understand that one of the most difficult aims of working with traumatic objects is linked to this transformation from saturated to unsaturated states. Traumatic objects become fixed in a saturated state, which does not allow them to undergo any transformation within the psyche or within the therapeutic analytic process. The saturated state of traumatic events or objects is a frozen state in which therapy or analysis is used to preserve rather than intervene. This creates, in quite a few cases, a situation that I call false therapy or false analysis - a process, a therapeutic process in which very detailed materials are ostensibly presented, but in fact they are presented in a way that forces the therapist or  to either swallow them as they are, or vomit them up but not digest them because they are presented in a way that does not tolerate any intervention, any other point of view, any creation of movement within the given frozen narrative."   Episode Description: We begin with describing the difference between 'saturated' and 'unsaturated' memories - those that are frozen and without the freedom to reflect from those that contain the capacity to create new meaning. Dana emphasizes the importance of not simply collecting the particulars of a trauma, the 'notes', as much as attending to the nature of its delivery, the 'music' - "the way they tell the story." She presents a case involving 'parasitic language' where imitation of the other is at the level of fetishistic attachment lacking a voice of their own. In her countertransference she noted "I search for you - all I find is myself." We consider how this pseudo-relating induces a peculiar sense of closeness that ultimately contributes to a sense of claustrophobia in the analyst. She shares with us her personal story and reflects "Being a psychoanalyst doesn't mean giving up being a musician." Dana concludes with reading her final paragraph on 'forgiveness.'   Our Guest: Dana Amir, PhD., is a clinical psychologist, supervising and training analyst at the Israel Psychoanalytic Society, full professor, and head of the interdisciplinary doctoral program in psychoanalysis at the Zramim Postgraduate Psychoanalytic Psychotherapy Program at Haifa University, poetess and literature researcher. She is the author of seven poetry books, four memoirs in prose, and five psychoanalytic books published by Routledge. She was awarded literary as well as academic prizes, including seven international psychoanalytic awards, including the prestigious Sigourney Award (2025).   Recommended Readings: Amir, D. (2012). The Inner Witness. The International Journal of Psycho-analysis, 93:879–896. Amir, D. (2013). The Chameleon Language of Perversion. Psychoanalytic Dialogues, 23: 393-407.   Amir, D. (2016). The Metaphoric, the Metonymic and the Psychotic aspects of Obsessive-Sympomatology. International Journal of Psychoanalysis, 97, 259–280.  Amir, D. (2016). Hermetic Narratives and False Analysis: A Unique Variant of the Mechanism of Identification with the Aggressor. Psychoanalytic Review 103(4):539-54 Amir, D. (2023). "From Turning Away to Turning Toward: Adoption as Radical Hospitality". Psychoanalytic Perspectives, 21: 1–18. Amir, D. (2024). From mind-deadness to mindedness, from collaboration to cooperation. International Journal of Applied Psychoanalytic Studies, 21(4).

Your body already knows how to release stress — but you've been taught to suppress it. In this Mind Architect episode, Dr. David Berceli, creator of TRE (Tension and Trauma Releasing Exercises), reveals how our natural tremor mechanism can help us discharge tension, process trauma, and restore balance.Dr. David Berceli developed TRE while living in war zones, observing how humans naturally contract and release during threat. His method has now spread to over 80 countries. Joining him is Elvira Stanescu, an internationally certified TRE provider who has been practicing for nearly 5 years. Facilitating the conversation is our colleague Adrian Dinu. We explored the following topics in our conversation with David and Elvira: Why children shake naturally during stress — and why adults suppress itHow tremoring communicates between the nervous system and brainThe difference between exhausting yourself through exercise vs. actual releaseHow TRE can help parents, athletes, helping professionals, and couplesCurrent research on TRE and depression from studies in ChinaResources mentioned:Dr. David Berceli's book on TRE (now available in Romanian) David's website Romanian TRE Association TRE Global website Dr. David Berceli's YouTube Channel for research results and tutorialsFive ongoing research projects in China examining brain activity changes with TRE, including studies on depressed teenagers and their parentsYou can join us live during episode recordings and get your questions answered directly by becoming a Mind Architect Premium Member here Episode produced in partnership with Editura Herald."(00:00) Introduction: The body's hidden stress release mechanism""(01:50) Welcome and episode overview""(03:55) How Dr. Berceli discovered TRE in war zones""(06:30) The tremor mechanism in all mammals""(08:35) What happens in the body when we tremor""(12:01) How people experience tremoring in the beginning""(14:07) Tension vs. trauma: Why both matter""(17:09) The risk of overwhelm and how to self-regulate""(20:13) Dos and don'ts: How to start practicing TRE safely""(23:57) TRE vs. exhausting exercise: What's the difference?""(26:32) How the body takes over and releases patterns""(29:14) TRE for athletes and military personnel""(36:41) Cultural adaptations: China, Latin America, Romania""(44:50) TRE for helping professionals: Coaches, therapists, trainers""(50:13) How to integrate mind and body without forcing it""(54:30) TRE for parents and family systems""(01:00:00) The body's ability to heal specific injuries""(01:01:48) Collective trauma and healing in community""(01:11:50) The future: Vibration, sound, and medicine""(01:14:45) Resources and where to learn more"

Get The Algorithm Deletion Exercise here: https://fos.now/yt-gd-discover-elon-musk-algorithm-checklistDo you want my help systematizing your business? Go here: https://fos.now/yt-apply-569In this video, I reveal the 5 operating mechanisms Elon Musk deploys across every company he operates. More importantly, the versions of these mechanisms you can use without destroying your life, your team, or your sanity. If you've ever wondered how one human builds rockets, cars, AI labs, and brain interfaces all while melting down on Twitter, here's the real answer.Want to LEARN proven systems to grow your personal brand? Go here: https://fos.now/yt-newsletter-569Already doing $30K+/month? Come to my next free workshop and I'll show you how to systemize your business and get your time back → https://fos.now/yt-workshop-569Want to WORK with a team of A-players? Apply to Founder OS here: https://www.founderos.com/careersConnect with me: Website: https://fos.now/yt-founder-os-569Twitter: https://twitter.com/matt_gray_ LinkedIn: https://www.linkedin.com/in/mattgray1 TikTok: https://www.tiktok.com/@realmattgray Instagram: https://instagram.com/matthgray00:00 - Intro00:55 - Mechanism 1: Maniacal Sense of Urgency04:50 - Mechanism 2: The Algorithm10:45 - Mechanism 3: Build Unreasonable Teams13:42 - Mechanism 4: Iterate at The Speed of Thought16:34 - Mechanism 5: Engineer to Scale Beyond Yourself#onepersonbusiness #creatoreconomy #entrepreneurshipDisclaimer: Information shared here is for educational purposes only. Individuals and business owners should evaluate their own business strategies and identify any potential risks. The information shared here is not a guarantee of success. Your results may vary. This video shares my personal experience and growth building businesses over 15+ years of consistent effort. Your results will vary depending on your own actions, strategies, and circumstances.

Obstetrician-gynecologist Priya Panneerselvam discusses their article "How medicine reflects women's silence." Priya discusses how the quiet deference observed in their mother's generation continues to manifest in patients who apologize for their pain and hesitate to ask questions. The conversation explores the cultural and national forces that suppress female voices, linking personal family history to the broader political landscape regarding women's rights and leadership. By examining the cost of this inherited silence, Priya advocates for speaking out as an act of rebellion and gratitude for those who could not. Breaking this cycle is necessary to honor the past while securing a freer future. Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

In this episode of Tech Talks, Mayer Brown partners Julian Dibbell, Brad Peterson, and Spencer Glende explore how companies can structure IP frameworks in contracts to support innovation in emerging technologies. They discuss why traditional contracting approaches often fall short in high-uncertainty environments and outline practical strategies—such as joint governance, flexibility, and aligned incentives—to help parties collaborate effectively and maximize long-term value. Show notes:  00:02 Introduction to IP Frameworks in Contracts for Emerging Technologies 2:00 Defining "emerging technology" 5:21 IP Contracting Perspective 11:09 How to build IP frameworks 12:19 Key 1: Clarity of Common Purpose 13:49 Key 2: Mechanism of Joint Steering Committees 19:26 Key 3: Maximizing Innovation Value 22:26 Key 4: Element of Flexibility and Optionality 26:24 Key Takeaways

"Send me a text"To learn more about the group coaching click here: https://creativethirst.com/group/You're spending $50 to acquire a customer who buys once and never returns. You've tested different creative, different audiences, different landing pages. Nothing works.The problem isn't your tactics. It's that you don't understand marketplace sophistication.Your market has heard every promise hundreds of times. They've tried dozens of supplements. They're skeptical and jaded. And you're marketing to them like it's 1995, making the same benefit promises everyone else makes.In this episode, you'll learn the five stages of marketplace sophistication and where supplement markets actually sit, why promises don't work anymore and what does (Unique Mechanisms), and how to create a Mechanism of Trust and Mechanism of Hope that makes your marketing actually work.Stop trying to out-promise your competition. Start competing on mechanism. That's supplement-specific thinking, and that's how you make marketing work in sophisticated markets.To learn more about the group coaching click here: https://creativethirst.com/group/If you're interested in working with me and my team to improve your supplement business. You can learn more at my website https://creativethirst.com Click here to grab your copy of the Health Supplement Ad Swipe Guide. Discover what really works in funnel marketing Need help increasing sales on your own? Click here Stuck at $1 - $5M in revenue? Click Here Case Study on how Creative Thirst added over $200,000 for one supplement brand

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In this episode of the Art of Catholic podcast, Matthew Leonard and author and professor Dr. Daniel Keating explore the astonishing Catholic doctrine of Deification.

Pimavanserin is an atypical antipsychotic approved for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. Unlike traditional antipsychotics, it does not block dopamine receptors, making it a unique option for patients with Parkinson’s disease who are highly sensitive to dopamine antagonism. Mechanism of Action Pimavanserin works primarily as a selective serotonin 5-HT2A inverse agonist and antagonist, with minor activity at 5-HT2C receptors. This dopamine-sparing effect is the key reason it does not worsen motor symptoms in Parkinson’s disease. Adverse Effects The most commonly reported side effects include peripheral edema, nausea, confusion, and hallucinations. QT interval prolongation is a clinically important concern, especially in patients with existing cardiac risk factors. Somnolence may occur but is generally less prominent compared with dopamine-blocking antipsychotics. Warnings and Precautions Pimavanserin carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis, consistent with other antipsychotics. It should not be used in patients with known QT prolongation, a history of ventricular arrhythmias, or in combination with other QT-prolonging agents when possible. Drug Interactions Strong CYP3A4 inhibitors, such as ketoconazole or clarithromycin, can significantly increase pimavanserin concentrations and require dose reduction. Strong CYP3A4 inducers, such as rifampin or carbamazepine, may reduce efficacy and should generally be avoided. Additive QT prolongation may occur when combined with other QT-prolonging medications, including certain antiarrhythmics, fluoroquinolones, and macrolide antibiotics. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Certified coach and professor Kathleen Muldoon and co-founder of Ryan House and Children's Respite Homes of America Jonathan Cottor discuss the article "The need for pediatric respite care." Kathleen shares the personal story of raising her son Gideon who lives with over 42 medical diagnoses and explain why the family had to move across the country to find safety. They highlight the critical difference between taking a break and surviving the relentless cycle of 24/7 medical vigilance required for medically complex children. The conversation advocates for the expansion of pediatric respite homes in the U.S. while urging clinicians to recognize that caregiver well-being is inseparable from patient health. We must acknowledge that keeping a family together often depends on the support they receive outside the hospital walls. Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

EU STRUGGLES WITH RUSSIAN ASSETS AND AID Colleague Judy Dempsey. Judy Dempsey discusses the EU's difficulty in utilizing frozen Russian assets and the "defeat" for Chancellor Merz regarding the funding mechanism for Ukraine. NUMBER 1 1890 SAXONY

What if thousands of steps of gentle walking aren't giving you the brain protection you think they are? In this solo episode, I break down one of the most important exercise studies published in Nature Communications and what it means for your brain, longevity, and Alzheimer's risk. Tracking over 73,000 people for eight years using wearables, the findings are shocking: one minute of vigorous exercise is worth up to 10 minutes of moderate activity — not the outdated 2-to-1 rule. For diabetes prevention, it's nearly 10-to-1. For cardiovascular mortality, it's 8-to-1. And here's what no one is saying: every outcome measured — heart disease, diabetes, metabolic dysfunction — is an independent risk factor for Alzheimer's and dementia. I explain why vigorous exercise is so powerful for your brain: shear stress that strengthens blood vessels, lactate that triggers BDNF, muscle fiber recruitment that protects against falls and cognitive decline, and glucose regulation that defends against insulin resistance — a driver of neurodegeneration. Think vigorous exercise is out of reach? Good news: the study defines it as brisk stairs, carrying groceries, or playing actively with your kids. No gym required — just effort. Just 3–4 minutes of vigorous bursts per day can reduce all-cause mortality by 40% and cardiovascular events by nearly 50%. For women over 40, this is critical. Two-thirds of Alzheimer's cases are women, and perimenopause is a vulnerability window for the brain. Vigorous exercise can partially compensate for declining estrogen by improving glucose regulation, reducing inflammation, and protecting the brain in ways gentle movement cannot. *** Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/brain-code-yt Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Rho NutritionYou can get 20% off with the code NEURO at https://rhonutrition.com Function HealthVisit https://functionhealth.com/louisa or use gift code NEURO100 at sign-up to own your health. AquaTruGo to https://AquaTru.com now for 20% off using promo code NEURO. TimelineHead to https://www.timeline.com/neuro to get 20% off. Cure HydrationGet 20% off your first order at https://curehydration.com/neuro with code NEURO. *** I'm Louisa Nicola — clinical neurophysiologist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Topics discussed:00:00:00 Introduction: The Exercise Intensity Revolution 00:01:02 The Study That Changes Everything 00:04:50 The Flawed Foundation: Why Guidelines Were Wrong 00:06:50 The Real Numbers: 4 to 10 Times More Powerful 00:08:53 The Brain Connection No One Is Talking About 00:15:32 Mechanism 1: Shear Stress and Cerebral Blood Flow 00:17:38 Mechanism 2: Lactate and BDNF Production 00:19:25 Mechanism 3: Type 2 Muscle Fibers and Myokines 00:24:30 Mechanism 4: Glucose Regulation and Mitochondrial Health 00:28:18 VILPA: The 3-Minute Daily Game Changer 00:32:16 Women and Menopause: The Critical Window 00:35:19 Practical Protocols: What to Do Starting Today Learn more about your ad choices. Visit megaphone.fm/adchoices

PREVIEW — Chris Riegel — "The Great Heist": China's Intellectual Property Theft Strategy. Riegel argues that Chinahas systematically employed intellectual property theft as a strategic mechanism to advance from technological desperation toward status as a near-peer American rival, systematically acquiring technologies while circumventing legitimate licensing and development pathways. Riegel documents that American corporations frequently ignored or tolerated Chinese IP theft in exchange for access to the lucrative Chinese domestic market, including the Cisco-Huaweicase illustrating corporate preference for market access over intellectual property protection. Riegel acknowledges that China now conducts original research and technological innovation, yet systematically rejects international intellectual property law regimes and refuses to recognize or enforce IP rights, maintaining institutional resistance to the legal frameworks protecting legitimate innovation and development within Western economies. 1922

2/8. Pigeons: The Great Communicators and Wartime Heroes — Steven Moss — Moss discusses the humble pigeon as a paradoxical feral bird species possessing extraordinary homing capabilities that made it invaluable as a communications mechanism. Although the famous narrative of Nathan Rothschild using pigeons following the Battle of Waterloo is apocryphal, pigeons were genuinely crucial wartime messengers. Moss emphasizes that pigeons were essential during the D-Day invasion due to radio silence protocols, and the celebrated pigeon Cher Ami saved imperiled soldiers during World War I. Moss notes that British forces even systematically killed Peregrine Falcons to protect pigeon communications, inadvertently contributing to the species' subsequent endangerment and near-extinction. 1869