Podcasts about Mechanism

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Solifenacin is a bladder antimuscarinic medication most commonly used for overactive bladder (OAB) with symptoms of urinary frequency, urgency, and urge incontinence. Like other agents in its class, understanding the pharmacology can help anticipate potential side effects, drug interactions, and downstream prescribing problems. Mechanism of Action Solifenacin selectively blocks muscarinic M3 receptors in the bladder detrusor muscle. Inhibiting these receptors reduces involuntary bladder contractions, increases bladder capacity, and delays the urge to void. While M3 selectivity may theoretically reduce side effects compared to nonselective antimuscarinics, in clinical practice, many anticholinergic effects still occur. Adverse Effects Because muscarinic receptors are present throughout the body, solifenacin can lead to a range of anticholinergic adverse effects: Dry mouth – among the most common, can be significant enough to cause dental issues with long-term use. Constipation – especially problematic in older adults; severe cases may require hospitalization. Blurred vision – due to impaired accommodation. Cognitive impairment – increased risk in older adults, particularly with cumulative anticholinergic burden. Urinary retention – paradoxical worsening in patients with bladder outlet obstruction. Drug Interactions CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) can increase solifenacin plasma concentrations, raising the risk of side effects. Other anticholinergics (e.g., diphenhydramine, tricyclic antidepressants, other bladder antimuscarinics) can result in additive toxicity and higher anticholinergic burden. QT-prolonging drugs (e.g., amiodarone, certain fluoroquinolones) may have additive cardiac risk since solifenacin has been associated with QT prolongation in rare cases. Prescribing Cascade Examples Constipation → Laxative initiation – A patient starts solifenacin for OAB and develops severe constipation, leading to chronic use of stimulant laxatives like senna or bisacodyl. Dry mouth → Mouth rinse prescription – Dry mouth is treated with saliva substitutes or prescription rinses, instead of reassessing the anticholinergic therapy. Cognitive decline → Donepezil initiation – In older adults, cognitive impairment may be mistaken for dementia progression, leading to cholinesterase inhibitor prescribing—directly counteracting the anticholinergic effects of solifenacin. Solifenacin can be an effective treatment for OAB, but the risk of adverse effects and prescribing cascades—especially in older adults—cannot be ignored. Healthcare professionals should regularly review the indication, monitor for anticholinergic burden, and look for opportunities to deprescribe when appropriate.

We Got This With Mark and Hal determines the best door opening mechanism of all time. This decision is legally binding.

PEEPanEIP - EIP-7892: Blob Parameter Only Hardforks PEEPanEIP - EIP-7892: Blob Parameter Only Hardforks In this episode, Pooja Ranjan discusses EIP 7892 with Mark Mackey, exploring its implications for Ethereum's scalability and the innovative approach to managing blob capacity. They delve into the technical aspects of the proposal, the importance of community involvement, and the future of Ethereum upgrades. Mark shares insights from his journey as a client developer and emphasizes the collaborative nature of the Ethereum community.

Watch hol+ by Dr. Taz MD on YouTube: https://www.youtube.com/@DrTazMD/podcastsAre you looking to proactively address metabolic disruptions and create a healthier lifestyle? In this episode of hol+, Dr. Taz MD explores the pressing issue of metabolic health and the economic burden of metabolic diseases, which cost around $427 billion annually. Dr. Taz addresses the common misconceptions about metabolic health, emphasizing that it encompasses more than just weight management. The episode delves into the mechanisms of GLP-1 medications, their effects, and the holistic strategies required to manage metabolic health effectively. By addressing inflammation, hormonal imbalances, and gut health, Dr. Taz provides a comprehensive guide to improving metabolic health for individuals and families alike. Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Stay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Host & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)05:30 The Financial Burden of Metabolic Disease08:19 Mechanism and Impact of GLP-1 Medications16:19 Diagnosing Metabolic Disease25:52 Medications: Finding the Right Balance29:17 Understanding Inflammation and Its Impact33:44 Hormones and Metabolic Health37:00 The Role of Gut Health in Metabolism39:11 Environmental Toxins and Metabolic Disease41:48 Building a Holistic Metabolic Plan44:44 Final Thoughts and Practical Steps

Melissa and Jam explore the science behind why sweat is salty. They discuss personal experiences with sweating, the types of sweat glands, and the chemical processes involved in sweat production. The episode explains how osmosis, ion channels, and salt concentrations contribute to the movement of sweat through sweat glands to the skin's surface. They also touch on evolutionary aspects and the role of sweat in cooling the body. For anyone curious about the chemistry of everyday life, this episode offers an accessible and intriguing explanation. 00:00 Introduction: Why is Sweat Salty? 00:27 Personal Experiences with Sweat 01:32 The Science Behind Sweat 02:00 Meet the Hosts 02:20 Types of Sweat Glands 04:30 How Sweat Reaches the Skin 07:31 The Role of Salt in Sweat 14:20 Health Indicators in Sweat 17:01 Understanding Osmosis and Interstitial Fluid 17:39 Evolutionary Perspective on Sweating 20:01 Mechanism of Sweat Glands 22:41 Sweat Composition and Function 27:39 Personal Sweating Experiences 33:47 Supporting the Show and Community ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife References from this episode: https://pmc.ncbi.nlm.nih.gov/articles/PMC6773238/ https://pubs.rsc.org/en/content/articlehtml/2024/lc/d3lc00874f#cit23 https://pubs.acs.org/doi/full/10.1021/acsnano.4c10344 Thanks to our monthly supporters Vince W Julie S. Heather R Autoclave Chelsea M Dorien VD Scott B Jessie R Ciara L J0HNTR0Y Jeannette N Cullyn R Erica B Elizabeth P Sarah M Rachel R Letila Katrina B Suzanne P Venus R Lyn S Jacob T Brian K Emerson W Kristina G Timothy P Steven B Chris and Claire S Chelsea B Avishai B Hunter R ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife

It's no secret that humans are conditioned to look for the negative.    The constant battle against negativity rages every single day.    Print.    TV.    Social media.    We can't get through our days without some negative news trying to penetrate our mentality.    What happens when we're faced with negativity is our brains are positioned to fight or flight.    But, what if there was a way to break out of this.    There is a way, and it takes focus, consistency, and practice.    And it's possible to do it easily.    The first thing you have to do is correct the trigger when you want to dive into the same stream of negativity the world brings you.    If someone wants to argue, find a way to diffuse it, no matter who is right or wrong.    When someone comes in and throws things into chaos, don't accept it as a problem you need to solve.    In moments of great stress,  and negativity, motivate yourself with love, gratitude, and abundance.    When you rewire your mind against its nature, you can operate from a place of love.    It's going to take some work, but when you do, watch the world you create change right in front of your face.    Most of the things we worry about never come to fruition.    Follow the path of inpenetrable positivity and let life flow.    About the ReWire Podcast   The ReWire Podcast with Ryan Stewman – Dive into powerful insights as Ryan Stewman, the HardCore Closer, breaks down mental barriers and shares actionable steps to rewire your thoughts. Each episode is a fast-paced journey designed to reshape your mindset, align your actions, and guide you toward becoming the best version of yourself. Join in for a daily dose of real talk that empowers you to embrace change and unlock your full potential.    Learn how you can become a member of a powerful community consistently rewiring itself for success at https://www.jointheapex.com/   Rise Above

Recorded with a live audience in Cambridge, this captivating conversation delves deep into the life and career of a cultural force of the last half-century. Known of course for his iconic role as Baldrick in Blackadder, Sir Tony's sharp intelligence and dry humour have had a formative influence on generations.  In this candid discussion, he opens up about the unexpected turns and profound challenges that have shaped his extraordinary journey as an actor, presenter, documentary maker and writer. You'll hear his deeply personal reflections on fatherhood, insights into the creative process behind his recently announced novel, and the powerful lessons learned from a lifetime of experiences, both public and private.  Prepare for an engaging, wise, and moving conversation that explores the transformative power of vulnerability and the importance of finding meaningful connection. This is a unique opportunity to hear a national treasure like never before. ✨ IN THIS EPISODE: 00:00 Intro 00:45 Tony Robinson's Early Life and Career 03:13 Fatherhood and Family 04:55 Writing and Publishing a Novel 10:50 The Impact of Blackadder 13:16 Challenges and Conflicts in Blackadder 16:33 Height and Personal Insecurities 20:42 Childhood and Adolescence Struggles 22:41 Growing Up in the Shadow of WWII 24:49 The Ups and Downs of Gambling 27:28 Early Career and Poker Lessons 29:29 Child Actor Earnings and Capitalism 34:23 Dealing with Alzheimer's in the Family 37:03 Reflecting on Personal Failures 44:56 Finding Meaningful Relationships

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Join us as we dive deep into pectoralis major tears. We'll discuss the anatomy of the pectoralis major, typical mechanisms of injury, and examination methods to diagnose these tears accurately. We also cover risk factors, differential diagnosis, and imaging options. Finally, we'll talk about treatment plans, both conservative and surgical, and the importance of understanding tissue healing timelines. 00:00 Introduction to the Podcast and Today's Topic01:18 Anatomy of the Pectoral Major02:10 Mechanism of Injury and Common Symptoms03:53 Assessment and Diagnosis06:38 Imaging and Differential Diagnosis07:31 Treatment Options: Conservative vs. Surgical08:44 Post-Surgical Rehabilitation Phases11:00 Key Takeaways and ConclusionSupport the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq: Get 10% off with code PTSNACKS10: [Tindeq] ...

About Bernardo:Bern Mendez is a neuroscience-based dating and relationship coach with 14 years of experience helping successful women thriving in midlife—but not yet in love—move past hidden emotional barriers into clear, committed relationships.His practical method blends neuroscience, trauma-informed somatic work, polyvagal theory, and attachment research, helping women regulate their nervous systems, clarify what they genuinely want, and choose partners who can truly meet them there.Bern's YouTube channel has drawn over 30 million views and 227,000 subscribers, making it one of the top 12 dating advice channels for women worldwide. Featured by CNN, HuffPost, Redbook, Univision, and MindBodyGreen, Bern coaches women globally from his home base in Austin, Texas.Summary:In this episode of the Better Divorce Podcast, host Paulette Rigo and guest Bern Mendez explore the complexities of dating and relationships post-divorce. They discuss how personal experiences shape our understanding of love and attraction, the role of the nervous system in partner selection, and the importance of self-awareness and emotional health in creating sustainable relationships. Bern shares his journey from personal pain to helping others navigate their relationship challenges, emphasizing the need for intentionality in dating and the significance of understanding attachment styles. The conversation highlights practical strategies for rewiring attraction patterns and recognizing unhealthy relationship dynamics, ultimately encouraging listeners to seek help and embrace personal growth. In this conversation, Bern Mendez and Paulette Rigo explore the complexities of modern dating, emphasizing the psychological and emotional aspects of connection. They discuss the addictive nature of dating apps, the importance of authenticity, and the pressures women face in the dating landscape. The dialogue also touches on the hero's journey in relationships, the balance between passion and stability, and the significance of flirting and human connection. Ultimately, they encourage listeners to take their time in finding love and to set healthy boundaries in their dating lives.Takeaways:The nervous system plays a crucial role in partner selection.Personal experiences, including loss, can drive one's purpose.Understanding attachment styles is vital for relationship success.Rewiring attraction patterns requires intentional effort.Breathing techniques can help regulate emotional responses.Recognizing unhealthy relationship dynamics is essential for healing.Seeking help is a sign of strength, not weakness.Relationships require ongoing learning and adaptation.Self-awareness is key to navigating post-divorce dating.Daily practices can facilitate personal growth and emotional health. The cycle of connection and addiction is real and affects dating.Modern dating can feel overwhelming due to societal pressures.Authenticity is crucial in finding the right partner.It's important to ask powerful questions early in dating.Healthy love should feel like a safe home, not chaos.Flirting is a lost art that needs to be revived.Dating can be a spiritual journey of self-discovery.Setting boundaries is essential for healthy relationships.Take the time to find the right person for you.You can absolutely get what you want in love if you learn the necessary skills.

Rachelle Robinett, founder of Pharmakon Supernatural and educator in holistic health, offers a clear, science-aware framework for supporting energy, focus, and stress regulation, without defaulting to pharmaceuticals or overstimulation. In this episode, she explores how plant-based medicine, nutrition, and daily practices can be woven into practical, long-term routines that support resilience and cognitive clarity.   Robinett challenges the assumption that performance must rely on synthetic energy or end in burnout. Drawing from her work at the intersection of herbalism and evidence-based wellness, she shares actionable strategies for optimizing physiological readiness through balance, not intensity.   “I'm really interested in how we can live well without needing to biohack or rely on pharmaceuticals or stimulants or even supplementation all the time.”   Key insights from the conversation include: Stimulants Borrow, Not Create Energy Robinett explains that caffeine and similar compounds don't give us energy; they “just turn off the signals of fatigue.” Instead, she emphasizes rhythm management, aligning with circadian patterns and energy cycles: “You don't have to be on all the time. And if we try to be, the crash will always come.”   Herbs Should Be Matched to Mechanism, Not Trend She encourages listeners to move beyond marketing labels like “adaptogen,” noting that compounds like rhodiola (stimulating) and reishi (sedating) serve very different roles.  “Match your plants to your goals... It's kind of like caffeine; if you don't need it, don't take it.”   Sugar Is Energizing, But Often Disruptive Robinett discusses how sugar can be paired with fiber, fat, or protein to reduce its volatility: “Sugar is biologically energizing… but we tend to use it in ways that give us a spike and then a crash.”   Daily Practices Outperform Sporadic Interventions Light exposure, meal timing, and breathwork help regulate the autonomic nervous system more effectively than isolated hacks: “What we do daily matters more than what we do occasionally… so many people don't understand how profoundly their breathing patterns are affecting their state.”   Recovery Is an Active Recalibration Robinett distinguishes between activities that feel restful and those that actually reset the stress response system: “Sometimes the things we think are relaxing are not—Netflix, alcohol, even yoga. True recovery is shifting the nervous system.”   This conversation reframes wellness not as indulgence or optimization, but as physiological literacy—a disciplined, systems-level approach to mental clarity and endurance. For professionals seeking alternatives to overstimulation, Robinett offers a sustainable path toward long-term resilience and regulated energy.   Get Rachelle's book here: https://shorturl.at/q7TDb Naturally: The Herbalist's Guide to Health and Transformation   Here are some free gifts for you: Overall Approach Used in Well-Managed Strategy Studies free download: www.firmsconsulting.com/OverallApproach   McKinsey & BCG winning resume free download: www.firmsconsulting.com/resumepdf   Enjoying this episode? Get access to sample advanced training episodes here: www.firmsconsulting.com/promo

Have you ever wondered what happens when a toddler gets into something they definitely shouldn't? Today, Dr. Monica Gray, Dr. Pradip Kamat, and Dr. Rahul Damania discuss the case of an 18-month-old boy who accidentally ingested concentrated bleach, presenting with stridor, drooling, and vomiting. They review the clinical approach to caustic ingestions in children, including airway management, diagnostic workup, and the roles of endoscopy, steroids, and multidisciplinary care. The episode also highlights potential complications such as esophageal strictures and cancer, emphasizes prevention strategies, and provides key takeaways for intensivists managing similar pediatric emergencies. If you're an intensivist or just want to know what to do in a pediatric emergency, don't miss these essential takeaways for managing one of the scariest situations in the ER.Show Highlights:Case study of an 18-month-old boy who ingested concentrated bleachClinical presentation including symptoms like stridor, drooling, and vomitingManagement strategies for caustic ingestions in childrenImportance of airway management and monitoring in cases of caustic ingestionDiagnostic workup including imaging and endoscopyDifferential diagnosis considerations for similar presentations (e.g., button batteries, laundry detergent pods)Mechanism of injury caused by alkaline substances like bleachLong-term complications associated with caustic ingestions, such as esophageal strictures and cancerMultidisciplinary approach to treatment involving various medical specialtiesPrevention strategies to reduce the incidence of accidental caustic ingestions in childrenReferences:American Academy of Pediatrics – Pediatric Care Online: Esophageal Caustic Injury (AAP clinical guidance on caustic ingestions).Fuhrman & Zimmerman's Pediatric Critical Care textbook – Chapters on toxicology and gastrointestinal emergencies (covering caustic injury management and critical care approach).Hoffman RS, et al. “Ingestion of Caustic Substances.” New England Journal of Medicine. 2020; 382(18):1739-1748. A comprehensive review of caustic ingestion injuries and management.Arnold M, Numanoglu A. “Caustic ingestion in children – a review.” Semin Pediatr Surg. 2017;26(2):95-104. Review of epidemiology, pathophysiology, and treatment of caustic injuries in kids.Johnson CM, Brigger MT. “The public health impact of pediatric caustic ingestion injuries.” Arch Otolaryngol Head Neck Surg. 2012;138(12):1111-1115. (Epidemiology study showing declining incidence).Pediatric Critical Care Medicine (PCCM) Journal – various case reports and series on caustic ingestion (for case-based insights), and annual National Poison Data System reports (for statistics on pediatric poisonings).Tringali A, et al. ESGE/ESPGHAN Pediatric GI Endoscopy Guidelines (Endoscopy, 2017) – Includes recommendations for endoscopy timing and steroid use in caustic ingestions.Usta M, et al. “High doses of methylprednisolone in the management of caustic esophageal burns.” Pediatrics. 2014;133(6):E1518-24. (Key study demonstrating steroids benefit in grade 2b injuries).Royal Children's Hospital Melbourne – Clinical Practice Guidelines: Caustic Ingestions (2019) – Practical hospital guidelines emphasizing early intubation for airway threat, endoscopy within 24h, IV PPI, and supportive care.

Steven Rabalais, litigator and author of General Fox Conner: Pershing's Chief of Operations and Eisenhower's Mentor,  joins the show to discuss the extraordinary influence of now-forgotten General Fox Connor on the outcome of WWI and Eisenhower's career.   ▪️ Times     •      01:51 Introduction     •      03:10 Growing up with history      •      05:47 A southern story      •      07:44 West Point struggles      •      12:07 A reader            •      14:50 Coastal artillery          •      20:46 Rocks and airplanes     •      23:51 Mechanism of victory     •      27:54 WWI logistics        •      32:47 Summer 1918     •      46:03 Eisenhower     •      51:24 Panama        •      01:01:58 Foreshadowing Follow along on Instagram, X @schoolofwarpod, and YouTube @SchoolofWarPodcast Find a transcript of today's episode on our School of War Substack

Researchers mainly from Kyoto University have found that impaired function of a specific gene contributes to the malignancy of pancreatic cancer, which is hard to treat with chemotherapy.

In this week's episode, we'll learn about a JAK inhibitor to prevent complications of CD19-directed CAR T-cell therapy. In a phase 2 study, itacitinib was well tolerated and demonstrated promising reductions in the incidence of cytokine release syndrome and neurotoxicity. After that: investigators report direct interactions between ChAdOx1 and platelets under arterial shear conditions. Investigators say it's a novel biophysical mechanism that potentially contributes to post-vaccination arterial thrombosis. Finally, we explore lineage switch, an emerging form of acute leukemia relapse with dismal outcomes. It arises rapidly following antigen-targeted immunotherapy, highlighting the importance of advanced methods for detection and treatment.Featured Articles: Itacitinib for the prevention of IEC therapy–associated CRS: results from the 2-part phase 2 INCB 39110-211 studyShear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosisProject EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

PodChatLive 189: The windlass mechanism on the moon, hip strength & ankle instability, and the impact of mental state on surgery outcomesContact us: getinvolved@podchatlive.comLinks from this week:Hip muscle strength in patients with chronic ankle instability: A systematic review and meta-analysisThe impact of mental and psychological state on metatarsophalangeal joint replacement outcomes in patients with freiberg's infractionAn Examination of Foot Dynamics under Terrestrial andLunar Gravity

Sid Mangalik and Andrew Clark explore the unique governance challenges of agentic AI systems, highlighting the compounding error rates, security risks, and hidden costs that organizations must address when implementing multi-step AI processes. Show notes:• Agentic AI systems require governance at every step: perception, reasoning, action, and learning• Error rates compound dramatically in multi-step processes - a 90% accurate model per step becomes only 65% accurate over four steps• Two-way information flow creates new security and confidentiality vulnerabilities. For example, targeted prompting to improve awareness comes at the cost of performance. (arXiv, May 24, 2025)• Traditional governance approaches are insufficient for the complexity of agentic systems• Organizations must implement granular monitoring, logging, and validation for each component• Human-in-the-loop oversight is not a substitute for robust governance frameworks• The true cost of agentic systems includes governance overhead, monitoring tools, and human expertiseMake sure you check out Part 1: Mechanism design, Part 2: Utility functions, and Part 3: Linear programming. If you're building agentic AI systems, we'd love to hear your questions and experiences. Contact us.What we're reading:We took reading "break" this episode to celebrate Sid! This month, he successfully defended his Ph.D. Thesis on "Psychological Health and Belief Measurement at Scale Through Language." Say congrats!>>What did you think? Let us know.Do you have a question or a discussion topic for the AI Fundamentalists? Connect with them to comment on your favorite topics: LinkedIn - Episode summaries, shares of cited articles, and more. YouTube - Was it something that we said? Good. Share your favorite quotes. Visit our page - see past episodes and submit your feedback! It continues to inspire future episodes.

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care. Timestamps 00:56 – What is Alpha-1 antitrypsin deficiency? 01:45 – Mechanism of this genetic disorder 03:12 – What makes Alpha 1 so hard to spot? 04:30 – Genetic complexities of Alpha 1 06:00 – Risk factors  

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/history

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/european-studies

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science-technology-and-society

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Writing Embodiment in Victorian Microscopy: Beautiful Mechanism (Oxford UP, 2025) by Dr. Meegan Kennedy examines a revolutionary period in microscopical technology and practice. At first considered a mere toy, by 1900 the microscope rivaled the railway and telegraph as an emblem of modernity and enjoyed an astonishing diversity of applications. This technology could drive scientific debates on subjects like cell theory, vitalism, and bacteriology; guide workers in classrooms, laboratories, and businesses; and inspire a personal hobby or a mass entertainment. Victorian microscopy productively cuts across the ostensibly separate domains of science, religion, commerce, art, education, entertainment, and domestic life.Writing Embodiment in Victorian Microscopy reads nineteenth-century microscopy across scientific, literary, religious, and popular texts. It argues that Victorian microscopists saw their vision and cognition as fully embodied experiences, the images emerging through a material entanglement of bodies (observer, instrument, apparatus, object) in a dynamic, unstable system. These ideas echo the work of physiological psychologists, who proposed mind as a system of embodied, distributed, and dynamic processes shaped by automatic or unconscious reflex action, attention, mental training, and fatigue. Striving to regulate this complex system, microscopists circulated tropes of embodiment through the varied forms of nineteenth-century print culture. They adapted existing concepts (such as beauty, the sublime, natural theology, and fairylands), or coined new phrases (such as many-sided comprehension), to promote favored forms of embodiment and enculturate microscopy as a difficult but valuable pursuit. Writing Embodiment draws on important work in book history and periodical studies by emphasizing the circulation of these tropes in intermedial conversations across diverse print forms.Victorians understood wonder and skepticism not as incommensurate approaches to scientific observation but rather as complementary forms of embodiment. Romantic tropes of wonder solicit affective flows from observer to wriggling animalcule and back; while skeptical, realist tropes offer to train the reader's eye, hand, body, and judgment and to formalize microscopical practice. Microscopical narratives may manipulate wonder and skepticism in productive tension or create virtual storyspaces that enlist the reader in virtual witnessing. These tropes shape every level of microscopical interest and proficiency. By analyzing their use and circulation, Writing Embodiment illuminates wider patterns of Victorian thought on embodiment, scientific practice, and community. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/british-studies

Sarah Kennedy of Calocurb discusses the natural and medical ways to suppress appetite, focusing on the revolutionary GLP-1 agonists (like Ozempic and Wegovy). This is truly a deep dive into the mechanism of GLP-1 and its role in regulating appetite and blood sugar. You will learn all about the innovative Calocurb supplement, founded by Sarah, which uses a patented hops extract to effectively increase GLP-1 and reduce calorie intake by 18%. A must-watch for women in midlife looking to manage their weight naturally.Go to https://calocurb.com/drstephanie to get 10% off your first purchaseEpisode overview (timestamps are approximate):(0:00) Intro/Teaser(7:00) Understanding GLP-1 and Appetite Suppression(24:00) Exploring the Effects of CaloCurb(39:00) Mechanism and Benefits of CaloCurb(43:00) Practical Strategies for Managing Hunger and Stress Eating(54:00) Research and the Future of Natural Appetite Suppression(1:03:00) BONUS: Dr. Stephanie's "After Party"Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep425A huge thanks to our sponsors:BEAM MINERALS - Replenish essential minerals your body needs. Visit https://beamminerals.com/better for 20% off of the entire store. The discount is auto-applied at checkout.LVLUP  - Midlife hormonal changes can wreak havoc on your gut health. Ultimate GI Repair combines powerful gut-healing peptides with gut-nourishing naturals to soothe your changing digestion. Learn more at https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% off.TIMELINE - As perimenopausal women, we know we are in a fight against time to preserve our muscle strength and endurance, plus our recovery needs are greater. That's why you save 20% at https://timelinenutrition.com/better with code BETTER.MAUI NUI VENISON - Packed with essential vitamins, minerals, and bioavailable compounds that support energy, performance, and overall health. Head over to  https://mauinuivenison.com/better to checkout their premium snack sticks and fresh starter boxes.

Have you ever wondered what happens when a toddler gets into something they definitely shouldn't? Today, Dr. Monica Gray, Dr. Pradip Kamat, and Dr. Rahul Damania discuss the case of an 18-month-old boy who accidentally ingested concentrated bleach, presenting with stridor, drooling, and vomiting. They review the clinical approach to caustic ingestions in children, including airway management, diagnostic workup, and the roles of endoscopy, steroids, and multidisciplinary care. The episode also highlights potential complications such as esophageal strictures and cancer, emphasizes prevention strategies, and provides key takeaways for intensivists managing similar pediatric emergencies. If you're an intensivist or just want to know what to do in a pediatric emergency, don't miss these essential takeaways for managing one of the scariest situations in the ER.Show Highlights:Case study of an 18-month-old boy who ingested concentrated bleachClinical presentation including symptoms like stridor, drooling, and vomitingManagement strategies for caustic ingestions in childrenImportance of airway management and monitoring in cases of caustic ingestionDiagnostic workup including imaging and endoscopyDifferential diagnosis considerations for similar presentations (e.g., button batteries, laundry detergent pods)Mechanism of injury caused by alkaline substances like bleachLong-term complications associated with caustic ingestions, such as esophageal strictures and cancerMultidisciplinary approach to treatment involving various medical specialtiesPrevention strategies to reduce the incidence of accidental caustic ingestions in childrenReferences:American Academy of Pediatrics – Pediatric Care Online: Esophageal Caustic Injury (AAP clinical guidance on caustic ingestions).Fuhrman & Zimmerman's Pediatric Critical Care textbook – Chapters on toxicology and gastrointestinal emergencies (covering caustic injury management and critical care approach).Hoffman RS, et al. “Ingestion of Caustic Substances.” New England Journal of Medicine. 2020; 382(18):1739-1748. A comprehensive review of caustic ingestion injuries and management.Arnold M, Numanoglu A. “Caustic ingestion in children – a review.” Semin Pediatr Surg. 2017;26(2):95-104. Review of epidemiology, pathophysiology, and treatment of caustic injuries in kids.Johnson CM, Brigger MT. “The public health impact of pediatric caustic ingestion injuries.” Arch Otolaryngol Head Neck Surg. 2012;138(12):1111-1115. (Epidemiology study showing declining incidence).Pediatric Critical Care Medicine (PCCM) Journal – various case reports and series on caustic ingestion (for case-based insights), and annual National Poison Data System reports (for statistics on pediatric poisonings).Tringali A, et al. ESGE/ESPGHAN Pediatric GI Endoscopy Guidelines (Endoscopy, 2017) – Includes recommendations for endoscopy timing and steroid use in caustic ingestions.Usta M, et al. “High doses of methylprednisolone in the management of caustic esophageal burns.” Pediatrics. 2014;133(6):E1518-24. (Key study demonstrating steroids benefit in grade 2b injuries).Royal Children's Hospital Melbourne – Clinical Practice Guidelines: Caustic Ingestions (2019) – Practical hospital guidelines emphasizing early intubation for airway threat, endoscopy within 24h, IV PPI, and supportive care.

On University at Albany Week: Understanding what drives antimicrobial resistance is crucial. Cheryl Andam, associate professor in the department of biological sciences at the RNA Institute, identifies a new mechanism. Cheryl Andam is an associate professor in UAlbany's Department of Biological Sciences. She works on the genome evolution of bacterial pathogens, with a focus on antimicrobial […]

We continue with our series about building agentic AI systems from the ground up and for desired accuracy.  In this episode, we explore linear programming and optimization methods that enable reliable decision-making within constraints. Show notes:Linear programming allows us to solve problems with multiple constraints, like finding optimal flights that meet budget requirementsThe Lagrange multiplier method helps find optimal solutions within constraints by reformulating utility functionsCombinatorial optimization handles discrete choices like selecting specific flights rather than continuous variablesDynamic programming techniques break complex problems into manageable subproblems to find solutions efficientlyMixed integer programming combines continuous variables (like budget) with discrete choices (like flights)Neurosymbolic approaches potentially offer conversational interfaces with the reliability of mathematical solversUnlike pattern-matching LLMs, mathematical optimization guarantees solutions that respect user constraintsMake sure you check out Part 1: Mechanism design and Part 2: Utility functions. In the next episode, we'll pull all of the components from these three episodes to demonstrate a complete travel agent AI implementation with code examples and governance considerations.What we're reading:Burn Book - Kara Swisher, March 2025Signal and the Noise - Nate Silver, 2012Leadership in Turbulent Times - Doris Kearns GoodwinWhat did you think? Let us know.Do you have a question or a discussion topic for the AI Fundamentalists? Connect with them to comment on your favorite topics: LinkedIn - Episode summaries, shares of cited articles, and more. YouTube - Was it something that we said? Good. Share your favorite quotes. Visit our page - see past episodes and submit your feedback! It continues to inspire future episodes.

Dr. Eduardo Cardona-Sanclemente, integrative medicine doctor with a focus on Ayurveda, has joined me (again) to share his brilliant insights. Please join us as we discuss: the inspiration behind his book: Ayurveda for Obesity and Gut Health his insights on the body/mind connection his philosophies on being grounded to nature an understanding of fat cells and so much more! Welcome to The Healing Place Podcast! I am your host, Teri Wellbrock. You can listen in on Pandora, Apple Podcasts, Spotify, iHeartRadio, Deezer, Amazon Music, and more, or directly on my website at www.teriwellbrock.com/podcasts/. You can also catch our insightful interview on YouTube. Bio: Dr. Eduardo Cardona-Sanclemente Dr. Eduardo Cardona-Sanclemente's medical and scientific career spans professorships and senior scientific research posts at a number of Europe's most distinguished medical schools and universities including The William Harvey Research Institute (WHRI, London); St. Bartholomew's Hospital Medical College (London); King's College London; Institut Pasteur (Paris); Salpêtrière Hospital (Paris); Institut Biomedical des Cordeliers (Paris); Sorbonne University (Paris) and the University of Perugia Medical School (Italy), In addition he has held Visiting Professors at AVP Hospital, Coimbatore (India) and S.D.M. College of Ayurveda, Udupi (India) where he taught postgraduate students, including in one of his specialism, lipid metabolism. He is an external supervisor for PhD students at Queen Mary University of London (QMUL). After graduating in Medical Sciences, he completed his Masters in Clinical Biochemistry and his PhD in the “Mechanism of Intake of Neurotransmitters” at the Sorbonne University (Paris). Following several years of medical and scientific research and published papers on the metabolism of cholesterol, he was awarded the Docteur d'Etat (Doctor of Science) in “Physiopathology of Nutrition by the Sorbonne, with the highest distinction (Très Honorable). Dr Cardona joined the WHRI in London under the Nobel laureate Sir John Vane, working with Professor Gustav Born on various aspects of Pathopharmacology. In parallel to his allopathic medical research and teaching, he has been studying and practicing integrative and Ayurvedic medicine for decades and holds a Masters in Ayurvedic Medicine from Middlesex University, UK, having completed internships at AVP Hospital Coimbatore and Udupi, India (2,000 hours+). He is a certified Ayurvedic Doctor by the National Ayurvedic Medical Association, USA (certified professional level) and has recently taught graduate students in Ayurveda at Bastyr University, Seattle and the University of New Mexico, NM. He is also a Member of the NHS Directory of Complementary & Alternative Practitioners, UK and presided for several years the Research Director of the Ayurvedic Professional Association (APA, UK). Dr. Cardona-Sanclemente is a Fellow of The Royal Society of Medicine (UK) and a Professional Member of the College of Medicine (UK). At present, he lives in Berkeley, CA and runs his private practice, and lectures nationally and internationally on Ayurveda, sharing his decades of experience at the interface of allopathic, integrative and Ayurvedic medical topics. He has delivered numerous engagements in building awareness and integration of the knowledge, efficacy and cost-effectiveness of Ayurveda and Integrative Medicine through developing health-related programs with academic, medical and non-profits organizations as part of his work for the integration and inclusion of minorities. Dr Cardona-Sanclemente has recently completed a book, due to be published in September 2020, on Ayurveda for Depression. He is fluent in English, Spanish, French and Italian. ​Website: https://www.eduardocardona.com/ Teri's #1 best-selling book and #1 new-release book can be found here.

Fat Loss & Metabolism with Dr. Ben Bikman Challenging the dogma surrounding heart disease. (1:32) Is there a connection between dementia and heart disease? (12:05) Strength training and Alzheimer's. (17:49) Learning something new helps put off dementia. (22:45) The connection between insulin resistance and your body's inability to fight off infection. (25:17) We put TOO much attention on total cholesterol. (27:55) Fat cells dynamics explained. (30:13) Why your metabolism is EXTREMELY complex. (44:14) Mitochondrial uncoupling. (48:51) Ketones and athletic performance. (55:39) The problem with DNP. (58:11) Why he is a HUGE advocate of creatine. (1:01:03) The brain loves ketones. (1:04:33) Keep your running shoes in the closet, GO STRENGTH TRAIN! (1:05:32) The metabolic origins of chronic disease. (1:08:10) How GLP-1s are being overused and the proper way to use them. (1:14:48) The resurgence of religion. (1:37:57) As a scientist, did he ever doubt his faith? (1:41:28) The most profound moment of his life. (1:45:51) Related Links/Products Mentioned Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease - and How to Fight It – Book by Dr. Benjamin Bikman How Not to Get Sick: A Cookbook and Guide to Prevent and Reverse Insulin Resistance, Lose Weight, and Fight Chronic Disease – Book by Dr. Benjamin Bikman Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at https://ketone.com/MINDPUMP June Special: Shredded Summer Bundle or Bikini Bundle 50% off! ** Code JUNE50 at checkout ** Most heart attack patients' cholesterol levels did not indicate cardiac risk Study: Doubling Saturated Fat in the Diet Does Not Increase Saturated Fat in Blood Insulin signal transduction pathway Mind Pump #1922: Fatphobia & Other Lies That Are Keeping You Fat, Unhealthy & Sick Diabulimia: Why This Eating Disorder Is So Dangerous for People with Diabetes Harris-Benedict equation - Wikipedia Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases DNP (Dinitrophenol): Overview, Mechanism, and Risks Mind Pump #2497: The Amazing & Weird Side Effects of Creatine Muscle strength and fitness linked to reduction in cancer deaths Fighting Cancer By Putting Tumor Cells On A Diet - NPR Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined Attenuated GLP-1 secretion in obesity: cause or consequence? Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Liraglutide modulates lipid metabolism via ZBTB20-LPL pathway Mind Pump #872: Dr. Warren Farrell- The Boy Crisis Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Benjamin Bikman (@benbikmanphd) Instagram Website Zach Bitter (@zachbitter) Instagram  Thomas N. Seyfried (@thomasseyfriedbc) Instagram Warren Farrell, PhD (@drwarrenfarrell) X/Twitter  

Should the final legislative steps proceed without delay, the EU's new visa rule may take effect by the fall of 2025.View the full article here.Subscribe to the IMI Daily newsletter here. 

Ten Years of the International Residual Mechanism for Criminal Tribunals: Achievements and Challenges

#496 Get Gritty with Off Road Triathlon   Welcome Welcome to Episode #496 of the 303 Endurance Podcast. We're your hosts Coaches Rich Soares and April Spilde. Thanks for joining us for another week of news, coaching tips and discussion.   The heat is on and triathlon race season is seriously under way here in the front range. We had a toasty day at IRONMAN Boulder 70.3 last weekend and the heat is on again this weekend for Xterra Lory with temperatures in the mid 90s.   Congratulations to everyone who raced last Saturday at IRONMAN Boulder 70.3!   April, are you ready to blaze the trails around Horsetooth Reservoir?   Hell yeah, Rich and YEE-HAW! I texted you earlier today that this race is going to feel like a high-octane rollar coaster all under your own power. Speaking of which how was you ride around Back Country?    Show Sponsor: UCAN UCAN created LIVSTEADY as an alternative to sugar based nutrition products. LIVSTEADY was purposefully designed to work with your body, delivering long-lasting energy you can feel. Whether UCAN Energy Powders, Bars or Gels, LIVSTEADY's unique time-release profile allows your body to access energy consistently throughout the day, unlocking your natural ability to finish stronger and recover more quickly!   In Today's Show Announcements and News (Rich) Ask A Coach: Race Report and the Growth Mindset (Rich) Get Gritty: Turning Race Day Nerves into Power! Clear the Mechanism TriDot Workout of the Week: Strength (Rich) Fun Segment: Trail Fail or Win?!   Announcements and News:   Our Announcements are supported by VESPA Power today. Endurance athletes—what if you could go farther, faster, and feel better doing it? With Vespa Power Endurance Nutrition, you can unlock your body's natural fat-burning potential and fuel performance without the sugar crash. Vespa helps you tap into steady, clean energy—so you stay strong, focused, and in the zone longer.  Vespa is not fuel, but a metabolic catalyst that shifts your body to use more fat and less glycogen as your fuel source.   Less sugar. Higher performance. Faster recovery.  Home of Vespa Power Products | Optimizing Your Fat Metabolism Use discount code - 303endurance20   Independence Day Pikes Peak Ride Jul 4, 2025 Join us for an invigorating bike ride from Santa's Workshop at 7700 feet to the top of Pikes Peak at 14,111. 6800 feet of climbing in 18 miles.  Garmin Course - https://connect.garmin.com/modern/course/369763602   TriDot Pool School July 26-27. https://www.tridotpoolschool.com/component/eventbooking/pool-school/tridot-pool-school-20250726-844-986-401-167-857/94?Itemid=762   Ask A Coach Sponsor: G2G Endurance Training alone is tough. Training smart? That's where we come in. Grit2Greatness Endurance + TriDot gives you optimized training, the data, and the support to crush your goals—without burning out. Try it FREE for 2 weeks through our TriDot links below, then roll into your best season yet for as low as $14.99/month. With the right tools, you're unstoppable. Go to the show notes. Click the link. Let's do this together! Website - Grit2Greatness Endurance Coaching Facebook page @grit2greatnessendurance   Coach April Spilde April.spilde@tridot.com TriDot Signup - https://app.tridot.com/onboard/sign-up/aprilspilde RunDot Signup - https://app.rundot.com/onboard/sign-up/aprilspilde    Coach Rich Soares Rich.soares@tridot.com Rich Soares Coaching TriDot Signup - https://app.tridot.com/onboard/sign-up/richsoares RunDot Signup - https://app.rundot.com/onboard/sign-up/richsoares   Ask A Coach: Race Report and the Growth Mindset  1. **What did you learn about yourself during this race that you didn't know before?**      _Encourages self-discovery and reflection beyond performance metrics._   2. **What part of your performance are you most proud of, and why?**      _Shifts focus to strengths and reinforces positive self-recognition._   3. **What was the most challenging moment, and how did you respond to it mentally and physically?**      _Promotes awareness of coping strategies and resilience._   4. **If you could relive one moment of the race, what would it be and what would you do differently?**      _Encourages constructive reflection and learning from experience._   5. **What thoughts or beliefs helped you push through discomfort or fatigue?**      _Highlights mental tools and mindset strategies that worked._   6. **Where did you notice self-doubt creeping in, and how did you handle it?**      _Brings awareness to limiting beliefs and how they were managed._   7. **What habits or decisions in your training showed up positively in your race?**      _Connects preparation to performance, reinforcing effective behaviors._   8. **What feedback would you give yourself as both the athlete and the coach?**      _Fosters dual perspective thinking and self-coaching skills._   9. **How did you define success before the race, and has that definition changed now?**      _Explores evolving values and mindset around achievement._   10. **What's one specific area you're excited to grow in before your next race, and why?**      _Focuses on forward momentum and intrinsic motivation._   Get Gritty Tip: Turning Race Day Nerves Into Power It's race day, and that familiar feeling is creeping in—the tight chest, sweaty palms, butterflies fluttering in your stomach. As athletes, we all know what pre-race anxiety feels like. The difference between elite athletes and those still finding their stride isn't that they don't experience nervousness—they feel it just as much as we do. But they've learned to frame it differently. Coach Steve Magness says it best: "Elite athletes don't feel less anxiety before competition. They feel the same tight chest, sweaty palms, racing heart, and butterflies that the rest of us do. The difference? They've trained themselves to interpret those sensations differently." This shift—from seeing nervousness as a threat to seeing it as a challenge—is where the magic happens. Research shows that high performers don't experience less stress—they just frame it better. Rather than trying to eliminate that anxious feeling, they embrace it, knowing it's a sign that they're ready to rise. Nerves aren't the enemy. In fact, they're your body's way of saying, “You care. Something meaningful is about to happen.” So, instead of running from it, lean into it. Understand that those nerves are helping you prepare, keeping you sharp, and sharpening your focus. They're not a sign of weakness—they're a sign of strength. We can often think that nervousness means something is wrong or that we're not prepared enough. But the reality is, it means you do care. It means your mind and body are ready for the challenge ahead. The goal isn't to eliminate the nerves, it's to work with them. See them as fuel, not fear. Feel them, acknowledge them, and let them guide you forward. When you feel those pre-race jitters, remind yourself: You're about to do something meaningful. Action item: Next time those race-day nerves hit, don't push them away. Instead, breathe into them. Let them be the signal that you're ready for the challenge. Harness that energy to fuel your focus, and remember, those butterflies are pushing you toward greatness. Ready to learn how to channel that energy?  Clear the Mechanism and Rise Above Nervousness before a race can feel overwhelming. But how do you take that energy and channel it into focus instead of letting it distract you? The answer lies in a simple but powerful mindset technique from For the Love of the Game, where Kevin Costner's character, a seasoned pitcher, uses the phrase “Clear the mechanism.” This technique isn't just for baseball—it's something every triathlete can use. When the nerves start to flood your mind, and you feel like you're about to be overwhelmed by the noise, distractions, and pressure, the key is to clear the mechanism. When you clear the mechanism, you're intentionally blocking out everything that isn't directly related to the task at hand. It's like hitting the reset button, shifting your focus from the fear and doubt to the one thing you can control: your next move. Whether it's your swim stroke, your pedal cadence, or your run stride, you zoom in on that one thing and let everything else fade away. Coach Steve Magness reminds us that nerves aren't the enemy—they're a sign that you care, that your body is getting ready. But we can use those nerves to fuel us, not flood us. And just like the pitcher who needs to block out the crowd, the score, and the noise, as a triathlete, you can clear out the mental clutter and focus on what's in front of you. Here's how to apply it: When the nerves hit, take a deep breath, and clear the mechanism. Shut down the distractions, the what-ifs, and the self-doubt. Focus on your next step—the one thing you can control right now. Maybe it's your breath, your form, or the rhythm of your movement. Acknowledge the nerves, then let them guide you forward, not pull you under. By clearing your mental space, you give yourself permission to focus on the task, to be fully present, and to perform at your best. It's not about eliminating the nerves; it's about making them work for you instead of against you.     Action item: Before your next race or workout, practice clearing the mechanism. When you feel overwhelmed, mentally shut out everything except for the next task at hand. Clear the mechanism, focus on your breath, and take control of the moment. You've trained for this. Let the nerves fuel your focus and guide you to greatness.   TriDot Workout of the Week: Strength Recovery Week Training - Strength Strength training is a crucial yet often overlooked component of triathlon preparation. Exercises like reverse lunges, single-leg deadlifts, and quadruped band kickbacks help build unilateral strength and stability, which are essential for efficient running and injury prevention. Core-focused movements such as plank reaches, V-ups, and half-kneeling rotations enhance balance, posture, and power transfer across all three disciplines. Functional exercises like burpees and cross-pull lawnmowers improve overall athleticism, coordination, and cardiovascular resilience. Together, these movements not only boost muscular endurance and joint integrity but also help triathletes maintain form under fatigue, reduce injury risk, and ultimately perform more consistently across swim, bike, and run segments.   Rotate 1-3x through the following exercises doing 10-20 repetitions or 30 to 60 sec efforts of each.   Reverse Lunge Single Leg Deadlifts Half-Kneeling Rotation Plank Reaches Cross Pulls Lawnmower Burpees V Ups One leg Quadruped Band Kickbacks     Fun Segment: Trail Fail or Win!   It's time for Trail Fail or Trail Win! — the game where we throw out some wild off-road triathlon scenarios, and Rich and I decide: was this a total disaster… or a sneaky success in disguise? Some of these could be race-ending nightmares—or just epic stories waiting to happen. Let's find out!   Scenario 1: The Wild Animal Detour Mid-race, a deer darts across the trail and you crash while trying to avoid it. You roll into the bushes, get back on your feet, and still finish 3rd in your age group—leaves and twigs in your helmet included.   Scenario 2: The Wrong-Turn Bonus Miles You miss a poorly marked turn on the trail run, add nearly 1.5 miles to your race, and come in well over your expected time. But… you didn't quit and still finished smiling.     Scenario 3: The Creek Shoe Sacrifice You nail the bike leg and enter the run feeling great… until you sink into a muddy creek crossing and one of your shoes stays behind. You finish the run with one barefoot foot.     Scenario 4: Transition Tent Tantrum Your gear bag somehow ends up in someone else's spot. You panic, yell a few expletives, throw your hands up—and then remember your gear is on the other side of the rack. You recover… barely.     Scenario 5: The Mid-Race Snack Catastrophe You reach for your trail mix on the bike—your new homemade “clean fuel”—and spill it all over your top tube. The rest of the ride, you're being followed by bees. You still PR the course! So whether you're dodging wildlife, losing shoes in creeks, or baiting bees with your snacks, remember—off-road triathlon isn't just a race. It's an adventure. Keep sending us your crazy scenarios, or better yet—live them. And we'll see you next time on Trail Fail or Win!   Closing:   Thanks again for listening this week. Please be sure to follow us @303Triathlon and @grit2greatnessendurance and of course go to iTunes and give us a rating and a comment. We'd really appreciate it! Stay tuned, train informed and enjoy the endurance journey!  

Europe Editor, Tony Connelly reports that the EU has activated its civil defence mechanism in order to help member states evacuate citizens from the Middle East.

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease" Rajesh Pahwa, MD, director of the Parkinson's Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD). Pahwa explains the rationale behind cell replacement therapy as a means to restore dopamine production, outlining the progression from fetal tissue implants to stem cell–derived dopaminergic neurons. He details key elements of the study design, including patient selection criteria, trial endpoints, and long-term goals. Reflecting on decades of research in this space, he emphasizes the potential impact of a one-time, hardware-free surgical option and how this novel approach could complement or shift the current treatment landscape. While many questions remain, Pahwa highlights the promise of bemdaneprocel as a next-generation option in Parkinson care. Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page. Episode Breakdown: 1:00 – Mechanism and rationale behind bemdaneprocel as a dopaminergic cell therapy 3:00– Key design considerations for conducting a registrational phase 3 cell therapy trial 5:25 – Trial structure, eligibility criteria, and ongoing patient recruitment 6:35 – Neurology News Minute 8:45 – Significance of reaching phase 3 with a cell therapy in Parkinson disease 10:20 – Future role of cell therapy within the Parkinson disease treatment landscape 12:10 – Unique aspects of the exPDite-2 trial and what sets it apart from earlier efforts The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: BTK Inhibitor Fenebrutinib Demonstrates Long-Term Suppression of MS Activity in Open-Label Extension REGENXBIO Reports Positive Phase 1/2 Data for Higher Dose of RGX-202 in Duchenne Muscular Dystrophy NewAmsterdam Pharma Reports Positive Topline Data of Alzheimer Agent Obicetrapib from Phase 3 BROADWAY Trial Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

In this episode, I sat down with Dr. Suzette Sutherland, a seasoned urologist who recently transitioned from the University of Washington to a large urology group in Arizona. Dr. Sutherland shares her expertise on treating overactive bladder (OAB) and the latest innovation in neuromodulation therapies, specifically focusing on the efficacy and safety of tibial nerve stimulation. We discuss the evolution of treatment guidelines, the pros and cons of various therapies, including medications, Botox, and sacral nerve stimulation, and dive deep into the promising results from the FDA-approved Revi device from BlueWind. Dr. Sutherland also sheds light on patient selection, procedural details, and patient compliance, while offering insights into the future of OAB treatments.For information on the REVI   https://bluewindmedical.com/Timeline:00:30 Introduction and Guest Introduction01:10 Understanding Overactive Bladder and Treatment Options02:19 Tibial Nerve Stimulation: A New Approach02:40 Changes in Treatment Guidelines05:57 Mechanism of Tibial Nerve Stimulation09:38 Implantable Tibial Nerve Stimulation Devices13:39 Patient Experience and Compliance17:54 Comparing Neuromodulation Devices25:37 Comparing Revi and Eco Devices26:32 Understanding Device Placement and Stimulation Frequency27:18 Battery Life and Replacement Concerns29:33 New Devices on the Horizon30:03 Meta-Analysis of Tibial Nerve Stimulation32:49 Patient Choices: Sacral Nerve Stimulation vs. Tibial Nerve Stimulation38:22 The Role of Botox in Bladder Treatment46:14 Challenges and Innovations in Urogynecology

How do you activate your brain's own healing mechanism?Meet Dr. Theodore Henderson!Dr. Theodore Henderson (psychiatrist) brings decades of clinical experience in psychopharmacology, neurobiology, infrared light therapy, and neuroimaging to the treatment of brain disorders. The Neuro-Luminance team, under Dr. Henderson, specializes in patients who have conditions which have been difficult to treat.In his book, Brighter Days Ahead, Dr. Henderson will help you see depression in a new light…leading you to powerfully effective treatments.Dr. Henderson paints a real-world picture of depression with moving stories and full color illustrations that makes the science underlying this common mental health condition come to life. He introduces other novel and powerful treatments for depression, as well as addressing childhood trauma, brain injury, inflammation, and the importance of mindfulness.Key Points:- how to activate your own brain's healing treatments- the neurological science behind the brain's healing- lifestyle improvements that contribute to healing- the science behind infrared light therapy- truly understanding depression ...and so much more!Connect with Dr. Henderson:Website: https://neuro-luminance.com/Additional Resources:"Brighter Days Ahead" by Dr. Theodore HendersonListen to the Podcast, subscribe, leave a rating and a review:Apple: https://podcasts.apple.com/us/podcast/activate-your-brains-own-healing-mechanism-w-dr-theodore/id1614151066?i=1000710812507Spotify: https://open.spotify.com/episode/00AMiRe7Wx7JFwRl7HuU1xhttps://open.spotify.com/episode/00AMiRe7Wx7JFwRl7HuU1x?si=09KK4Hl-RbCAk7OlGS2KwAYouTube: https://youtu.be/Ky4TOPxgVTQ

The Alan Cox ShowSee omnystudio.com/listener for privacy information.

The Alan Cox Show

Researchers Find the Mechanism Behind Potential AnticancerProperties in LidocaineBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/researchers-find-the-mechanism-behind-potential-anticancer-properties-in-lidocaine/Need CE? Start earning CE credits today at ⁠⁠⁠⁠⁠https://rdh.tv/ce⁠⁠⁠⁠⁠Get daily dental hygiene articles at ⁠⁠⁠⁠⁠https://www.todaysrdh.com⁠⁠⁠⁠⁠ Follow Today's RDH on Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/TodaysRDH/⁠⁠⁠⁠⁠Follow Kara RDH on Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠⁠⁠⁠⁠Follow Kara RDH on Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/kara_rdh/

437: Neal McDonough—Clear the Mechanism The perennial character actor villain turned leading man drops by to talk about the first film where he finally gets to kiss the girl at the end, The Last Rodeo—and that girl is played by his wife, Ruvé. Coincidence? Not a chance. That's the only way Neal would do it. Neal also discusses how he secured a return to Taylor Sheridan's Tulsa Kings, why he thought Sylvester Stallone might deck him on set, and the greatest career advice Clint Eastwood gave him. Today's episode is sponsored by CompanyCam.com Jobsite photo tools to manage work from anywhere. American-Giant.com/MIKE Use code MIKE to get 20% off your order. skillsusa.org/mike Join the skilled trade movement! Watch People You Should Know on Mike's YouTube Channel

Join the conversation in our community at https://butjesusdrankwine.com/community.  In this special episode, we got to guest-host Dr. Lee Warren's Spiritual Self-Brain Surgery podcast to discuss the first five of his 10 Commandments of Self-Brain Surgery—powerful principles that combine neuroscience and faith to help you overcome challenges and break free from the destructive patterns in your life, including alcohol use. We dive into the intersection of neuroscience and spirituality, sharing how you can take charge of your thoughts, emotions, and actions to create lasting transformation. Using Dr. Lee's commandments as a guide, we explore how you can change your brain by changing your mind. Commandments 1-5: 1️⃣ I Must Relentlessly Refuse to Participate in My Own Demise You're either building your brain—or breaking it. Every thought, feeling, belief, and action either propels you forward or holds you hostage. This commandment emphasizes the choice to embrace life with each decision, fostering a mindset of resilience and growth. 2️⃣ I Must Believe That Feelings Are Not Facts; They Are Chemical Events in My Brain Emotions are signals, not truths. They're data, not destiny. We discuss how to honor your feelings without being controlled by them, and how to act on what's true, even when your emotions are telling you something different. 3️⃣ I Must Believe That Most of My Automatic Thoughts Are Untrue Your brain's default mode is not designed for joy or truth; it's built for survival. This means that many of your automatic thoughts are unreliable. We dive into how to challenge these thoughts and train your brain to align with your true mind—moving from survival mode to thriving. 4️⃣ I Must Believe That My Mind Is in Charge of My Brain This is a game-changer. You're not a victim of your neurochemistry. You can actually change it. We explore how taking control of your mind allows you to access hope, healing, and peace. Mind-over-brain is key to lasting transformation. 5️⃣ I Must Believe That Self–Brain Surgery Is Not a Metaphor; It is the Mechanism of Transforming My Life Self-brain surgery is real—it's not just a metaphor. Your thoughts are like a scalpel that can cut out toxic patterns and implant healthier ones. This principle is grounded in neuroplasticity and aligns with biblical renewal (Romans 12:2). We share how this concept works in both science and Scripture. Key Takeaways: How to stop sabotaging your own growth and choose life with every thought and action Why emotions are signals, not truths, and how to process them without letting them control you The importance of challenging automatic thoughts and rewiring your brain for joy and truth Understanding mind-over-brain control and its impact on your life The power of self-brain surgery and how it leads to true transformation Scripture Reference: Romans 12:2 – "Do not conform to the pattern of this world, but be transformed by the renewing of your mind." We hope this episode inspires you to take charge of your thoughts and actions, and ultimately, to live a life free from the destructive patterns that hold you back. Join us next week as we continue with the next five commandments of self-brain surgery.   Listen to Dr. Lee Warren's podcasts: The Self-Brain Surgery Podcast and Spiritual Brian Surgery with Dr. Lee Warren.    Learn more about Dr. Lee Warren and subscribe to his substack here.    Join our private, small-group coaching space, The Missing Peace, and get BJDW all-community access for free! https://butjesusdrankwine.com/coaching Order Christy's book now available! Love Life Sober, A 40 Day Alcohol Fast To Rediscover Your Joy, Improve Your Health and Renew Your Mind  Learn More about Coaching with Christy https://www.lovelifesober.co.uk/   Learn More about Coaching with Meade https://meadehollandshirley.com/   Connect with us on Instagram! @imnotsoberimfree @lovelifesoberwithchristy @butjesusdrankwine   You can find this episode on YouTube HERE.   The creators, hosts, and producers of the But Jesus Drank Wine podcast are not healthcare practitioners and therefore do not give medical, psychological or professional advice nor do they intend for the podcast, any communication on behalf of BJDW or otherwise to be a substitute for such. Additionally, the views and opinions expressed in any mention of and/or linked resources are those of the authors/owners of those resources and do not necessarily reflect the views or opinions of the But Jesus Drank Wine podcast team or guests of the show.  

In this conversation, Nina and Carrie delve into the complexities of catastrophic thinking and high functioning anxiety. Nina shares her personal experiences with catastrophic thoughts, particularly in her roles as a professional and a mother. Carrie, a therapist specializing in high functioning anxiety, explains the nature of this anxiety and how it manifests in seemingly successful individuals. They discuss the disconnect between external appearances and internal struggles, the mechanisms behind catastrophic thinking, and the roots of these thought patterns. The conversation also explores the differences between anticipatory anxiety and healthy preparation, providing insights into managing these feelings effectively. In this conversation, Nina and Carrie Howard delve into the complexities of catastrophic thinking, exploring its roots in fear and anxiety. They discuss how different individuals experience catastrophic thoughts in various situations and provide practical strategies for recognizing and managing these thoughts. The conversation emphasizes the importance of sitting with discomfort and uncertainty, as well as offering support to loved ones who may struggle with anxiety. Carrie shares valuable techniques for grounding oneself and fostering a sense of safety, ultimately encouraging listeners to cultivate self-awareness and compassion in their mental health journeys. 00:00: Understanding Catastrophic Thinking03:05: High Functioning Anxiety Explained06:03: The Disconnect Between Appearance and Reality08:34: Defining Catastrophic Thinking09:13: The Mechanism of Catastrophic Thinking11:37: The Roots of Catastrophic Thinking17:51: Anticipatory Anxiety vs. Catastrophic Thinking19:10: Healthy Preparation vs. Catastrophic Thinking20:50: Understanding Catastrophic Thinking23:56: Practical Strategies to Combat Catastrophizing30:06: Sitting with Discomfort and Uncertainty34:00: Supporting Others Through Catastrophic Thinking Carrie Howard is a licensed anxiety therapist, mental health educator, and content creator who specializes in high-functioning anxiety, overthinking, perfectionism, and people-pleasing. With over a decade of clinical experience—and a personal journey with anxiety herself—she helps women face their fears, build self-trust, and navigate life with more confidence and calm. Carrie's work has been featured in outlets like Good Morning America, Shape, HuffPost, and Verywell Mind, and she's known for blending professional insight with a deeply compassionate, relatable approach. Episode Sponsor: Get started at factormeals.com/mamaknows50off and use code mamaknows50off to get 50 percent off plus FREE shipping on your first box. Learn more about your ad choices. Visit megaphone.fm/adchoices

Tetanus has probably been around for most of human history, or even longer. But it’s preventable today thanks to vaccines. Research: "Emil von Behring." Notable Scientists from 1900 to the Present, edited by Brigham Narins, Gale, 2008. Gale In Context: Science, link.gale.com/apps/doc/K1619001490/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=464250e5. Accessed 17 Apr. 2025. Breasted, J.H., translator. “OIP 3. The Edwin Smith Surgical Papyrus, Volume 1: Hieroglyphic Transliteration, Translation, and Commentary.” Oxford University Press. 1930. Chalian, William. “An Essay on the History of Lockjaw.” Bulletin of the History of Medicine, FEBRUARY, 1940, Vol. 8, No. 2. Via JSTOR. https://www.jstor.org/stable/44446242 Emil von Behring: The founder of serum therapy. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/behring/article/ Galassi, Francesco Maria et al. “Tetanus: historical and palaeopathological aspects considering its current health impact.” Journal of preventive medicine and hygiene vol. 65,4 E580-E585. 31 Jan. 2025, doi:10.15167/2421-4248/jpmh2024.65.4.3376 George, Elizabeth K. “Tetanus (Clostridium tetani Infection).” StatPearls. January 2025. https://www.ncbi.nlm.nih.gov/books/NBK482484/ Hippocrates. “VI. Diseases, Internal Affections.” Harvard University Press. 1988. Jean-Marc Cavaillon, Historical links between toxinology and immunology, Pathogens and Disease, Volume 76, Issue 3, April 2018, fty019, https://doi.org/10.1093/femspd/fty019 Jones CE, Yusuf N, Ahmed B, Kassogue M, Wasley A, Kanu FA. Progress Toward Achieving and Sustaining Maternal and Neonatal Tetanus Elimination — Worldwide, 2000–2022. MMWR Morb Mortal Wkly Rep 2024;73:614–621. DOI: http://dx.doi.org/10.15585/mmwr.mm7328a1 Kaufmann, Stefan H E. “Remembering Emil von Behring: from Tetanus Treatment to Antibody Cooperation with Phagocytes.” mBio vol. 8,1 e00117-17. 28 Feb. 2017, doi:10.1128/mBio.00117-17 Kreston, Rebecca. “Tetanus, the Grinning Death.” Discover. 9/29/2015. https://www.discovermagazine.com/health/tetanus-the-grinning-death Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 14 Apr. 2025. Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 15 Apr. 2025. National Institutes of Health. “Tetanus.” https://history.nih.gov/display/history/Tetanus Ni, Maoshing. “The Yellow Emperor's Classic of Medicine: A New Translation of the Neijing Suwen with Commentary.” Shambhala. 1995. Smithsonian. “The Antibody Initiative: Battling Tetanus.” https://www.si.edu/spotlight/antibody-initiative/battling-tetanus Sundwall, John. “Man and Microbes.” Illustrated lecture given under the auspices of the Kansas Academy of Science, Topeka, January 12, 1917. https://archive.org/details/jstor-3624335/ The Nobel Prize in Physiology or Medicine 1901. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/summary/ Tiwari, Tejpratap S.P. et al. “Chapter 21: Tetanus.” CDC Pink Book. https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-21-tetanus.html Von Behring, Emil and Kitasato Shibasaburo. “The Mechanism of Immunity in Animals to Diphtheria and Tetanus.” Immunology. 1890. http://raolab.org/upfile/file/20200612164743_201234_56288.pdf War Office Committee for the Study of Tetanus. “Memorandum on Tetanus.” Fourth Edition. 1919. https://archive.org/details/b32171201/ World Health Organization. “Tetanus.” 7/12/2024. https://www.who.int/news-room/fact-sheets/detail/tetanus See omnystudio.com/listener for privacy information.

Episode: 1369 Fokker and the machine gun interrupter mechanism.  Today, we meet a nice young man and his killing machines.

In this episode, the Surgical Endoscopy team, accompanied by Chief Medical Officer Dr. Brian Dunkin of Boston Scientific, review primary and revisional endoscopic treatment options for bariatric patients. They focus on the emerging data available for procedures such as endoscopic sleeve gastroplasty (ESG) and endoscopic gastrojejunal revision (EGJR) and offer technical tips on how to perform the procedures. In addition, they discuss accessibility challenges for patients and provide insight into the future direction of bariatric endoscopy as a field.  Hosts: ·      Dr. Sullivan “Sully” Ayuso, Minimally Invasive Surgery, Endeavor Health (Evanston, IL), @SAyusoMD (Twitter) ·      Dr. Trevor Crafts, Minimally Invasive Surgeon, Rocky Mountain VA Medical Center (Denver, CO), @CraftsTrevor (Twitter)  ·      Dr. H. Masson Hedberg, Minimally Invasive Surgeon, Endeavor Health (Evanston, IL) ·      Dr. Michael Ujiki, Professor and Louis Biegler Chair of Surgery, Endeavor Health (Evanston, IL), @UjikiMike ·      Dr. Brian Dunkin, Chief Medical Officer at Boston Scientific, @briandunkinmd Learning Objectives:  -       Identify and Describe Common Endobariatric Procedures: Learners will be able to name and briefly describe at least three common endobariatric procedures discussed in the episode, including Endoscopic Sleeve Gastroplasty (ESG), Endoscopic GJ Revisions (Transoral Outlet Reduction - TORR/EGJR), and Intragastric Balloons, along with their historical context and evolution. -       Explain the Mechanism and Benefits of Endoscopic Sleeve Gastroplasty (ESG): Learners will be able to articulate the procedural technique of ESG, including the U-shaped suture pattern, its impact on gastric volume reduction, and the proposed mechanisms of weight loss, such as slowed gastric emptying and hormonal changes, as compared to laparoscopic sleeve gastrectomy. -       Discuss the Role of Technology and Training in Endobariatrics: Learners will be able to explain the significance of endoscopic suturing devices like the Overstitch in the advancement of endobariatric procedures and recognize the importance of specialized training, including the recommendations against fundal suturing for safety during the initial learning curve. -       Compare and Contrast Endobariatric Procedures with Surgical and Pharmacological Obesity Treatments: Learners will be able to discuss the position of endobariatric procedures as a "gap therapy" in the spectrum of obesity treatments, highlighting their benefits such as reduced invasiveness, lower complication rates, faster recovery, and increased patient access compared to surgery, as well as their potential role in conjunction with pharmacologic therapies like GLP-1 agonists. -       Recognize Key Considerations and Potential Complications of Endobariatric Procedures: Learners will be able to identify important technical considerations during ESG, such as achieving full-thickness bites while avoiding injury to adjacent organs, and describe common post-procedure issues associated with intragastric balloons, including nausea, vomiting, and the need for general anesthesia during removal. Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity: https://pubmed.ncbi.nlm.nih.gov/39888616/ Surgical Endoscopy Series Ep. 1: An Introduction to Surgical Endoscopy: https://app.behindtheknife.org/podcast/surgical-endoscopy-series-ep-1-an-introduction-to-surgical-endoscopy Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen