Podcasts about Mechanism

The Alan Cox Show

Researchers Find the Mechanism Behind Potential AnticancerProperties in LidocaineBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/researchers-find-the-mechanism-behind-potential-anticancer-properties-in-lidocaine/Need CE? Start earning CE credits today at ⁠⁠⁠⁠⁠https://rdh.tv/ce⁠⁠⁠⁠⁠Get daily dental hygiene articles at ⁠⁠⁠⁠⁠https://www.todaysrdh.com⁠⁠⁠⁠⁠ Follow Today's RDH on Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/TodaysRDH/⁠⁠⁠⁠⁠Follow Kara RDH on Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠⁠⁠⁠⁠Follow Kara RDH on Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/kara_rdh/

One out of four Americans has Fatty Liver Disease and Doesn't Even Know It. Are you one? with Phil George Series #3: NAFLD ( non alcoholic fatty liver disease) at least one out of 4 Americans have it and don't know they do until they have serious liver damage that can result in Cirrhosis or liver cancer + I can relate this to metabolic syndrome and excess carbs and as always I can explain “Mechanism or Action” or how you get this “silent Killer” Bio: Phil has spent most of his adult life educating and helping clients live a healthier, more fulfilling life. He is a clinical biochemist/certified personal trainer/health coach. As a biochemist, he was trained to understand “the mechanism of action” or what is causing the problem as opposed to just throwing medications at the illness. Many clients/listeners say that Phil makes complicated subjects much easier to understand. He was hired by a veteran's group and gave seminars throughout New England. Phil continues to give seminars to senior centers and other groups in New England. For the past two years Phil has been the host of a popular radio and TV show in Central Massachusetts, WellnessWave Radio,LLC. on WCRN in Boston, MA. Affiliations: Society of Metabolic Health Practitioners Nutrition Coalition Root Cause Practitioners Please feel free to email him at philgeorge@charter.net with any health/nutrition/exercise questions. https://www.wellnesswave.net/ Be sure to tune into his Radio Show “Wellness Wave Radio LLC” on Dreamvisions 7 Radio Network every Wednesday 11am/11pmET Learn more: https://dreamvisions7radio.com/wellness-wave-radio-llc/  Call In and Chat with Deborah during Live Show: 833-220-1200 or 319-527-2638 Learn more about Deborah here:  www.lovebyintuition.com

437: Neal McDonough—Clear the Mechanism The perennial character actor villain turned leading man drops by to talk about the first film where he finally gets to kiss the girl at the end, The Last Rodeo—and that girl is played by his wife, Ruvé. Coincidence? Not a chance. That's the only way Neal would do it. Neal also discusses how he secured a return to Taylor Sheridan's Tulsa Kings, why he thought Sylvester Stallone might deck him on set, and the greatest career advice Clint Eastwood gave him. Today's episode is sponsored by CompanyCam.com Jobsite photo tools to manage work from anywhere. American-Giant.com/MIKE Use code MIKE to get 20% off your order. skillsusa.org/mike Join the skilled trade movement! Watch People You Should Know on Mike's YouTube Channel

What if we've been approaching AI agents all wrong? While the tech world obsesses over larger language models (LLMs) and prompt engineering, there'a a foundational approach that could revolutionize how we build trustworthy AI systems: mechanism design.This episode kicks off an exciting series where we're building AI agents "the hard way"—using principles from game theory and microeconomics to create systems with predictable, governable behavior. Rather than hoping an LLM can magically handle complex multi-step processes like booking travel, Sid and Andrew explore how to design the rules of the game so that even self-interested agents produce optimal outcomes.Drawing from our conversation with Dr. Michael Zargum (Episode 32), we break down why LLM-based agents struggle with transparency and governance. The "surface area" for errors expands dramatically when you can't explain how decisions are made across multiple steps. Instead, mechanism design creates clear states with defined optimization parameters at each stage—making the entire system more reliable and accountable.We explore the famous Prisoner's Dilemma to illustrate how individual incentives can work against collective benefits without proper system design. Then we introduce the Vickrey-Clark-Groves mechanism, which ensures AI agents truthfully reveal preferences and actively participate in multi-step processes—critical properties for enterprise applications.Beyond technical advantages, this approach offers something profound: a way to preserve humanity in increasingly automated systems. By explicitly designing for values, fairness, and social welfare, we're not just building better agents—we're ensuring AI serves human needs rather than replacing human thought.Subscribe now to follow our journey as we build an agentic travel system from first principles, applying these concepts to real business challenges. Have questions about mechanism design for AI? Send them our way for future episodes!What did you think? Let us know.Do you have a question or a discussion topic for the AI Fundamentalists? Connect with them to comment on your favorite topics: LinkedIn - Episode summaries, shares of cited articles, and more. YouTube - Was it something that we said? Good. Share your favorite quotes. Visit our page - see past episodes and submit your feedback! It continues to inspire future episodes.

Join the conversation in our community at https://butjesusdrankwine.com/community.  In this special episode, we got to guest-host Dr. Lee Warren's Spiritual Self-Brain Surgery podcast to discuss the first five of his 10 Commandments of Self-Brain Surgery—powerful principles that combine neuroscience and faith to help you overcome challenges and break free from the destructive patterns in your life, including alcohol use. We dive into the intersection of neuroscience and spirituality, sharing how you can take charge of your thoughts, emotions, and actions to create lasting transformation. Using Dr. Lee's commandments as a guide, we explore how you can change your brain by changing your mind. Commandments 1-5: 1️⃣ I Must Relentlessly Refuse to Participate in My Own Demise You're either building your brain—or breaking it. Every thought, feeling, belief, and action either propels you forward or holds you hostage. This commandment emphasizes the choice to embrace life with each decision, fostering a mindset of resilience and growth. 2️⃣ I Must Believe That Feelings Are Not Facts; They Are Chemical Events in My Brain Emotions are signals, not truths. They're data, not destiny. We discuss how to honor your feelings without being controlled by them, and how to act on what's true, even when your emotions are telling you something different. 3️⃣ I Must Believe That Most of My Automatic Thoughts Are Untrue Your brain's default mode is not designed for joy or truth; it's built for survival. This means that many of your automatic thoughts are unreliable. We dive into how to challenge these thoughts and train your brain to align with your true mind—moving from survival mode to thriving. 4️⃣ I Must Believe That My Mind Is in Charge of My Brain This is a game-changer. You're not a victim of your neurochemistry. You can actually change it. We explore how taking control of your mind allows you to access hope, healing, and peace. Mind-over-brain is key to lasting transformation. 5️⃣ I Must Believe That Self–Brain Surgery Is Not a Metaphor; It is the Mechanism of Transforming My Life Self-brain surgery is real—it's not just a metaphor. Your thoughts are like a scalpel that can cut out toxic patterns and implant healthier ones. This principle is grounded in neuroplasticity and aligns with biblical renewal (Romans 12:2). We share how this concept works in both science and Scripture. Key Takeaways: How to stop sabotaging your own growth and choose life with every thought and action Why emotions are signals, not truths, and how to process them without letting them control you The importance of challenging automatic thoughts and rewiring your brain for joy and truth Understanding mind-over-brain control and its impact on your life The power of self-brain surgery and how it leads to true transformation Scripture Reference: Romans 12:2 – "Do not conform to the pattern of this world, but be transformed by the renewing of your mind." We hope this episode inspires you to take charge of your thoughts and actions, and ultimately, to live a life free from the destructive patterns that hold you back. Join us next week as we continue with the next five commandments of self-brain surgery.   Listen to Dr. Lee Warren's podcasts: The Self-Brain Surgery Podcast and Spiritual Brian Surgery with Dr. Lee Warren.    Learn more about Dr. Lee Warren and subscribe to his substack here.    Join our private, small-group coaching space, The Missing Peace, and get BJDW all-community access for free! https://butjesusdrankwine.com/coaching Order Christy's book now available! Love Life Sober, A 40 Day Alcohol Fast To Rediscover Your Joy, Improve Your Health and Renew Your Mind  Learn More about Coaching with Christy https://www.lovelifesober.co.uk/   Learn More about Coaching with Meade https://meadehollandshirley.com/   Connect with us on Instagram! @imnotsoberimfree @lovelifesoberwithchristy @butjesusdrankwine   You can find this episode on YouTube HERE.   The creators, hosts, and producers of the But Jesus Drank Wine podcast are not healthcare practitioners and therefore do not give medical, psychological or professional advice nor do they intend for the podcast, any communication on behalf of BJDW or otherwise to be a substitute for such. Additionally, the views and opinions expressed in any mention of and/or linked resources are those of the authors/owners of those resources and do not necessarily reflect the views or opinions of the But Jesus Drank Wine podcast team or guests of the show.  

Did you know that some weight loss medications can help people lose up to 20% of their body weight, comparable to bariatric surgery outcomes? In this episode, I dive into the latest research comparing two major weight loss medications, Wegovy (semaglutide) and Zepbound (tirzepatide), based on findings from the 72-week SURMOUNT-5 trial. I explain how Zepbound led to greater weight loss (about 20.2% vs. 13.7% with Wegovy), possibly due to its dual action on GIP and GLP-1 receptors. Both drugs were generally well tolerated, with similar side effects like nausea and constipation, though Wegovy had slightly more people stop due to GI issues. I also emphasize that while Zepbound may appear more effective, individual needs, such as cardiovascular health or sleep apnea, should guide treatment decisions. Lastly, I remind you that sustainable weight loss requires patience, realistic expectations, and a holistic approach that includes lifestyle changes, not just medication. Tune in to this episode to learn which weight loss medication might be right for you and why your journey to health is more than just the number on the scale.   Episode Highlights: Comparison of Wegovy (semaglutide) and Zepbound (tirzepatide) Average weight loss outcomes and waist circumference changes between both medications Mechanism of action: GLP-1 vs. dual GIP/GLP-1 receptor targeting Side effect profiles and tolerability of both medications FDA approval differences, including cardiovascular risk reduction and sleep apnea treatment Importance of personalized treatment plans and setting realistic weight loss expectations Ongoing research into oral formulations and long-term safety studies Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

The Quaternion Drive: How This Mechanism Could Be Game-Changing for Humanoid Robotics by Marwa ElDiwiny

6 - ASEAN+3 launches new financial mechanism, moving away from dollar by Australian Citizens Party

The following article of the Trade & Invesment industry is: “The Hidden Impacts of the Rapid Response Labor Mechanism” by Erick Diaz, Independent Contributor.

In this conversation, Nina and Carrie delve into the complexities of catastrophic thinking and high functioning anxiety. Nina shares her personal experiences with catastrophic thoughts, particularly in her roles as a professional and a mother. Carrie, a therapist specializing in high functioning anxiety, explains the nature of this anxiety and how it manifests in seemingly successful individuals. They discuss the disconnect between external appearances and internal struggles, the mechanisms behind catastrophic thinking, and the roots of these thought patterns. The conversation also explores the differences between anticipatory anxiety and healthy preparation, providing insights into managing these feelings effectively. In this conversation, Nina and Carrie Howard delve into the complexities of catastrophic thinking, exploring its roots in fear and anxiety. They discuss how different individuals experience catastrophic thoughts in various situations and provide practical strategies for recognizing and managing these thoughts. The conversation emphasizes the importance of sitting with discomfort and uncertainty, as well as offering support to loved ones who may struggle with anxiety. Carrie shares valuable techniques for grounding oneself and fostering a sense of safety, ultimately encouraging listeners to cultivate self-awareness and compassion in their mental health journeys. 00:00: Understanding Catastrophic Thinking03:05: High Functioning Anxiety Explained06:03: The Disconnect Between Appearance and Reality08:34: Defining Catastrophic Thinking09:13: The Mechanism of Catastrophic Thinking11:37: The Roots of Catastrophic Thinking17:51: Anticipatory Anxiety vs. Catastrophic Thinking19:10: Healthy Preparation vs. Catastrophic Thinking20:50: Understanding Catastrophic Thinking23:56: Practical Strategies to Combat Catastrophizing30:06: Sitting with Discomfort and Uncertainty34:00: Supporting Others Through Catastrophic Thinking Carrie Howard is a licensed anxiety therapist, mental health educator, and content creator who specializes in high-functioning anxiety, overthinking, perfectionism, and people-pleasing. With over a decade of clinical experience—and a personal journey with anxiety herself—she helps women face their fears, build self-trust, and navigate life with more confidence and calm. Carrie's work has been featured in outlets like Good Morning America, Shape, HuffPost, and Verywell Mind, and she's known for blending professional insight with a deeply compassionate, relatable approach. Episode Sponsor: Get started at factormeals.com/mamaknows50off and use code mamaknows50off to get 50 percent off plus FREE shipping on your first box. Learn more about your ad choices. Visit megaphone.fm/adchoices

Is back pain and sciatica interfering with the quality of your daily life? We have good news for you as we have back pain and sciatica relief near you! Prevention is always better than cure, so do not wait until surgery is the only remaining option for sciatica and back pain relief! Dr. Jason Jones Chiropractor Care is readily available to offer you the natural treatment needed to alleviate pain and restore your general productivity. Be sure to schedule an appointment with our Chiropractor, Jason Jones, today at our Chiropractic office in Elizabeth City, NC. The chiropractor will guide you in restoring your body's balance while relaxing the muscles, relieving you from aggravating back pain and sciatica. After chiropractic care with Dr. Jason Jones, you can rest assured of becoming more energetic and delighted as you carry on your daily activities. The major areas that the chiropractic care for back by Dr. Jason Jones will address include: ·         Mechanism of action This entails using manual adjustments in manipulating the spine, such as sensations using needles and pins, to rectify misalignments that may be causing pain after compressing nerves. ·         Treatment approach Dr. Jason Jones will conduct a comprehensive body examination to determine the source of the pain. Such examinations include your posture assessment, nerve function, and ability to sustain a range of motion. He will then apply targeted adjustments to the affected segments. After the encounter with the doctor, you will have reduced pains, enhanced spine motion, become more flexible with better muscle tone, and improved overall productivity. Among the non-surgical back pain and sciatica relief treatments the doctor will tackle include: ·         Decompression care Using a specialized decompression table, our chiropractor will apply gentle traction to create intervertebral spaces for the disks that had been compressed to retract and ease pressure on the surrounding nerves. Please do not lose this golden opportunity for your long-sought back pain and sciatica relief. ·         Practice home care Did you know that the solution to your chronic back pain and mild sciatica could just be next to you, at your home? Home care activities, such as applying heat and cold packs, regular walking and stretching, relaxing your shoulders, and sitting or walking straight, go an extra mile in alleviating pain. ·         Advise on comprehensive care with movement Based on your condition, the chiropractor will advise you on comprehensive care with movement activities such as physical activity, exercises, low-impact activities, and core strengthening activities. These will help you become more flexible, improve your core, and correct your posture and alignment. Can't wait to feel good again? Please book an appointment with our chiropractor, Dr. Jason Jones, for better chiropractic care. Whether you are living with back pain or sciatica, there is a solution for you after booking an appointment with our chiropractor.  

Listen to ASCO's JCO Oncology Practice, Art of Oncology Practice article, "An Oncologist's Guide to Ensuring Your First Medical Grand Rounds Will Be Your Last” by Dr. David Johnson, who is a clinical oncologist at University of Texas Southwestern Medical School. The article is followed by an interview with Johnson and host Dr. Mikkael Sekeres. Through humor and irony, Johnson critiques how overspecialization and poor presentation practices have eroded what was once internal medicine's premier educational forum. Transcript Narrator: An Oncologist's Guide to Ensuring Your First Medical Grand Rounds Will Be Your Last, by David H. Johnson, MD, MACP, FASCO   Over the past five decades, I have attended hundreds of medical conferences—some insightful and illuminating, others tedious and forgettable. Among these countless gatherings, Medical Grand Rounds (MGRs) has always held a special place. Originally conceived as a forum for discussing complex clinical cases, emerging research, and best practices in patient care, MGRs served as a unifying platform for clinicians across all specialties, along with medical students, residents, and other health care professionals. Expert speakers—whether esteemed faculty or distinguished guests—would discuss challenging cases, using them as a springboard to explore the latest advances in diagnosis and treatment. During my early years as a medical student, resident, and junior faculty member, Grand Rounds consistently attracted large, engaged audiences. However, as medicine became increasingly subspecialized, attendance began to wane. Lectures grew more technically intricate, often straying from broad clinical relevance. The patient-centered discussions that once brought together diverse medical professionals gradually gave way to hyperspecialized presentations. Subspecialists, once eager to share their insights with the wider medical community, increasingly withdrew to their own specialty-specific conferences, further fragmenting the exchange of knowledge across disciplines. As a former Chair of Internal Medicine and a veteran of numerous MGRs, I observed firsthand how these sessions shifted from dynamic educational exchanges to highly specialized, often impenetrable discussions. One of the most striking trends in recent years has been the decline in presentation quality at MGR—even among local and visiting world-renowned experts. While these speakers are often brilliant clinicians and investigators, they can also be remarkably poor lecturers, delivering some of the most uninspiring talks I have encountered. Their presentations are so consistently lackluster that one might suspect an underlying strategy at play—an unspoken method to ensure that they are never invited back. Having observed this pattern repeatedly, I am convinced that these speakers must be adhering to a set of unwritten rules to avoid future MGR presentations. To assist those unfamiliar with this apparent strategy, I have distilled the key principles that, when followed correctly, all but guarantee that a presenter will not be asked to give another MGR lecture—thus sparing them the burden of preparing one in the future. Drawing on my experience as an oncologist, I illustrate these principles using an oncology-based example although I suspect similar rules apply across other subspecialties. It will be up to my colleagues in cardiology, endocrinology, rheumatology, and beyond to identify and document their own versions—tasks for which I claim no expertise. What follows are the seven “Rules for Presenting a Bad Medical Oncology Medical Grand Rounds.” 1.  Microscopic Mayhem: Always begin with an excruciatingly detailed breakdown of the tumor's histology and molecular markers, emphasizing how these have evolved over the years (eg, PAP v prostate-specific antigen)—except, of course, when they have not (eg, estrogen receptor, progesterone receptor, etc). These nuances, while of limited relevance to general internists or most subspecialists (aside from oncologists), are guaranteed to induce eye-glazing boredom and quiet despair among your audience. 2. TNM Torture: Next, cover every nuance of the newest staging system … this is always a real crowd pleaser. For illustrative purposes, show a TNM chart in the smallest possible font. It is particularly helpful if you provide a lengthy review of previous versions of the staging system and painstakingly cover each and every change in the system. Importantly, this activity will allow you to disavow the relevance of all previous literature studies to which you will subsequently refer during the course of your presentation … to wit—“these data are based on the OLD staging system and therefore may not pertain …” This phrase is pure gold—use it often if you can. NB: You will know you have “captured” your audience if you observe audience members “shifting in their seats” … it occurs almost every time … but if you have failed to “move” the audience … by all means, continue reading … there is more! 3. Mechanism of Action Meltdown: Discuss in detail every drug ever used to treat the cancer under discussion; this works best if you also give a detailed description of each drug's mechanism of action (MOA). General internists and subspecialists just LOVE hearing a detailed discussion of the drug's MOA … especially if it is not at all relevant to the objectives of your talk. At this point, if you observe a wave of slack-jawed faces slowly slumping toward their desktops, you will know you are on your way to successfully crushing your audience's collective spirit. Keep going—you are almost there. 4. Dosage Deadlock: One must discuss “dose response” … there is absolutely nothing like a dose response presentation to a group of internists to induce cries of anguish. A wonderful example of how one might weave this into a lecture to generalists or a mixed audience of subspecialists is to discuss details that ONLY an oncologist would care about—such as the need to dose escalate imatinib in GIST patients with exon 9 mutations as compared with those with exon 11 mutations. This is a definite winner! 5. Criteria Catatonia: Do not forget to discuss the newest computed tomography or positron emission tomography criteria for determining response … especially if you plan to discuss an obscure malignancy that even oncologists rarely encounter (eg, esthesioneuroblastoma). Should you plan to discuss a common disease you can ensure ennui only if you will spend extra time discussing RECIST criteria. Now if you do this well, some audience members may begin fashioning their breakfast burritos into projectiles—each one aimed squarely at YOU. Be brave … soldier on! 6. Kaplan-Meier Killer: Make sure to discuss the arcane details of multiple negative phase II and III trials pertaining to the cancer under discussion. It is best to show several inconsequential and hard-to-read Kaplan-Meier plots. To make sure that you do a bad job, divide this portion of your presentation into two sections … one focused on adjuvant treatment; the second part should consist of a long boring soliloquy on the management of metastatic disease. Provide detailed information of little interest even to the most ardent fan of the disease you are discussing. This alone will almost certainly ensure that you will never, ever be asked to give Medicine Grand Rounds again. 7. Lymph Node Lobotomy: For the coup de grâce, be sure to include an exhaustive discussion of the latest surgical techniques, down to the precise number of lymph nodes required for an “adequate dissection.” To be fair, such details can be invaluable in specialized settings like a tumor board, where they send subspecialists into rapturous delight. But in the context of MGR—where the audience spans multiple disciplines—it will almost certainly induce a stultifying torpor. If dullness were an art, this would be its masterpiece—capable of lulling even the most caffeinated minds into a stupor. If you have carefully followed the above set of rules, at this point, some members of the audience should be banging their heads against the nearest hard surface. If you then hear a loud THUD … and you're still standing … you will know you have succeeded in giving the world's worst Medical Grand Rounds!   Final Thoughts I hope that these rules shed light on what makes for a truly dreadful oncology MGR presentation—which, by inverse reasoning, might just serve as a blueprint for an excellent one. At its best, an outstanding lecture defies expectations. One of the most memorable MGRs I have attended, for instance, was on prostaglandin function—not a subject typically associated with edge-of-your-seat suspense. Given by a biochemist and physician from another subspecialty, it could have easily devolved into a labyrinth of enzymatic pathways and chemical structures. Instead, the speaker took a different approach: rather than focusing on biochemical minutiae, he illustrated how prostaglandins influence nearly every major physiologic system—modulating inflammation, regulating cardiovascular function, protecting the gut, aiding reproduction, supporting renal function, and even influencing the nervous system—without a single slide depicting the prostaglandin structure. The result? A room full of clinicians—not biochemists—walked away with a far richer understanding of how prostaglandins affect their daily practice. What is even more remarkable is that the talk's clarity did not just inform—it sparked new collaborations that shaped years of NIH-funded research. Now that was an MGR masterpiece. At its core, effective scientific communication boils down to three deceptively simple principles: understanding your audience, focusing on relevance, and making complex information accessible.2 The best MGRs do not drown the audience in details, but rather illuminate why those details matter. A great lecture is not about showing how much you know, but about ensuring your audience leaves knowing something they didn't before. For those who prefer the structured wisdom of a written guide over the ramblings of a curmudgeon, an excellent review of these principles—complete with a handy checklist—is available.2 But fair warning: if you follow these principles, you may find yourself invited back to present another stellar MGRs. Perish the thought! Dr. Mikkael SekeresHello and welcome to JCO's Cancer Stories: The Art of Oncology, which features essays and personal reflections from authors exploring their experience in the oncology field. I'm your host, Mikkael Sekeres. I'm Professor of Medicine and Chief of the Division of Hematology at the Sylvester Comprehensive Cancer Center, University of Miami.  What a pleasure it is today to be joined by Dr. David Johnson, clinical oncologist at the University of Texas Southwestern Medical School. In this episode, we will be discussing his Art of Oncology Practice article, "An Oncologist's Guide to Ensuring Your First Medical Grand Rounds Will Be Your Last."  Our guest's disclosures will be linked in the transcript.  David, welcome to our podcast and thanks so much for joining us. Dr. David JohnsonGreat to be here, Mikkael. Thanks for inviting me. Dr. Mikkael SekeresI was wondering if we could start with just- give us a sense about you. Can you tell us about yourself? Where are you from? And walk us through your career. Dr. David JohnsonSure. I grew up in a small rural community in Northwest Georgia about 30 miles south of Chattanooga, Tennessee, in the Appalachian Mountains. I met my wife in kindergarten. Dr. Mikkael SekeresOh my. Dr. David JohnsonThere are laws in Georgia. We didn't get married till the third grade. But we dated in high school and got married after college. And so we've literally been with one another my entire life, our entire lives. Dr. Mikkael SekeresMy word. Dr. David JohnsonI went to medical school in Georgia. I did my training in multiple sites, including my oncology training at Vanderbilt, where I completed my training. I spent the next 30 years there, where I had a wonderful career. Got an opportunity to be a Division Chief and a Deputy Director of, and the founder of, a cancer center there. And in 2010, I was recruited to UT Southwestern as the Chairman of Medicine. Not a position I had particularly aspired to, but I was interested in taking on that challenge, and it proved to be quite a challenge for me. I had to relearn internal medicine, and really all the subspecialties of medicine really became quite challenging to me. So my career has spanned sort of the entire spectrum, I suppose, as a clinical investigator, as an administrator, and now as a near end-of-my-career guy who writes ridiculous articles about grand rounds. Dr. Mikkael SekeresNot ridiculous at all. It was terrific. What was that like, having to retool? And this is a theme you cover a little bit in your essay, also, from something that's super specialized. I mean, you have had this storied career with the focus on lung cancer, and then having to expand not only to all of hematology oncology, but all of medicine. Dr. David JohnsonIt was a challenge, but it was also incredibly fun. My first few days in the chair's office, I met with a number of individuals, but perhaps the most important individuals I met with were the incoming chief residents who were, and are, brilliant men and women. And we made a pact. I promised to teach them as much as I could about oncology if they would teach me as much as they could about internal medicine. And so I spent that first year literally trying to relearn medicine. And I had great teachers. Several of those chiefs are now on the faculty here or elsewhere. And that continued on for the next several years. Every group of chief residents imparted their wisdom to me, and I gave them what little bit I could provide back to them in the oncology world. It was a lot of fun. And I have to say, I don't necessarily recommend everybody go into administration. It's not necessarily the most fun thing in the world to do. But the opportunity to deal one-on-one closely with really brilliant men and women like the chief residents was probably the highlight of my time as Chair of Medicine. Dr. Mikkael SekeresThat sounds incredible. I can imagine, just reflecting over the two decades that I've been in hematology oncology and thinking about the changes in how we diagnose and care for people over that time period, I can only imagine what the changes had been in internal medicine since I was last immersed in that, which would be my residency. Dr. David JohnsonWell, I trained in the 70s in internal medicine, and what transpired in the 70s was kind of ‘monkey see, monkey do'. We didn't really have a lot of understanding of pathophysiology except at the most basic level. Things have changed enormously, as you well know, certainly in the field of oncology and hematology, but in all the other fields as well. And so I came in with what I thought was a pretty good foundation of knowledge, and I realized it was completely worthless, what I had learned as an intern and resident. And when I say I had to relearn medicine, I mean, I had to relearn medicine. It was like being an intern. Actually, it was like being a medical student all over again. Dr. Mikkael SekeresOh, wow. Dr. David JohnsonSo it's quite challenging.  Dr. Mikkael SekeresWell, and it's just so interesting. You're so deliberate in your writing and thinking through something like grand rounds. It's not a surprise, David, that you were also deliberate in how you were going to approach relearning medicine. So I wonder if we could pivot to talking about grand rounds, because part of being a Chair of Medicine, of course, is having Department of Medicine grand rounds. And whether those are in a cancer center or a department of medicine, it's an honor to be invited to give a grand rounds talk. How do you think grand rounds have changed over the past few decades? Can you give an example of what grand rounds looked like in the 1990s compared to what they look like now? Dr. David JohnsonWell, I should all go back to the 70s and and talk about grand rounds in the 70s. And I referenced an article in my essay written by Dr. Ingelfinger, who many people remember Dr. Ingelfinger as the Ingelfinger Rule, which the New England Journal used to apply. You couldn't publish in the New England Journal if you had published or publicly presented your data prior to its presentation in the New England Journal. Anyway, Dr. Ingelfinger wrote an article which, as I say, I referenced in my essay, about the graying of grand rounds, when he talked about what grand rounds used to be like. It was a very almost sacred event where patients were presented, and then experts in the field would discuss the case and impart to the audience their wisdom and knowledge garnered over years of caring for patients with that particular problem, might- a disease like AML, or lung cancer, or adrenal insufficiency, and talk about it not just from a pathophysiologic standpoint, but from a clinician standpoint. How do these patients present? What do you do? How do you go about diagnosing and what can you do to take care of those kinds of patients? It was very patient-centric. And often times the patient, him or herself, was presented at the grand rounds. And then experts sitting in the front row would often query the speaker and put him or her under a lot of stress to answer very specific questions about the case or about the disease itself.  Over time, that evolved, and some would say devolved, but evolved into more specialized and nuanced presentations, generally without a patient present, or maybe even not even referred to, but very specifically about the molecular biology of disease, which is marvelous and wonderful to talk about, but not necessarily in a grand round setting where you've got cardiologists sitting next to endocrinologists, seated next to nephrologists, seated next to primary care physicians and, you know, an MS1 and an MS2 and et cetera. So it was very evident to me that what I had witnessed in my early years in medicine had really become more and more subspecialized. As a result, grand rounds, which used to be packed and standing room only, became echo chambers. It was like a C-SPAN presentation, you know, where local representative got up and gave a talk and the chambers were completely empty. And so we had to go to do things like force people to attend grand rounds like a Soviet Union-style rally or something, you know. You have to pay them to go. But it was really that observation that got me to thinking about it.  And by the way, I love oncology and I'm, I think there's so much exciting progress that's being made that I want the presentations to be exciting to everybody, not just to the oncologist or the hematologist, for example. And what I was witnessing was kind of a formula that, almost like a pancake formula, that everybody followed the same rules. You know, “This disease is the third most common cancer and it presents in this way and that way.” And it was very, very formulaic. It wasn't energizing and exciting as it had been when we were discussing individual patients. So, you know, it just is what it is. I mean, progress is progress and you can't stop it. And I'm not trying to make America great again, you know, by going back to the 70s, but I do think sometimes we overthink what medical grand rounds ought to be as compared to a presentation at ASH or ASCO where you're talking to subspecialists who understand the nuances and you don't have to explain the abbreviations, you know, that type of thing. Dr. Mikkael SekeresSo I wonder, you talk about the echo chamber of the grand rounds nowadays, right? It's not as well attended. It used to be a packed event, and it used to be almost a who's who of, of who's in the department. You'd see some very famous people who would attend every grand rounds and some up-and-comers, and it was a chance for the chief residents to shine as well. How do you think COVID and the use of Zoom has changed the personality and energy of grand rounds? Is it better because, frankly, more people attend—they just attend virtually. Last time I attended, I mean, I attend our Department of Medicine grand rounds weekly, and I'll often see 150, 200 people on the Zoom. Or is it worse because the interaction's limited? Dr. David JohnsonYeah, I don't want to be one of those old curmudgeons that says, you know, the way it used to be is always better. But there's no question that the convenience of Zoom or similar media, virtual events, is remarkable. I do like being able to sit in my office where I am right now and watch a conference across campus that I don't have to walk 30 minutes to get to. I like that, although I need the exercise. But at the same time, I think one of the most important aspects of coming together is lost with virtual meetings, and that's the casual conversation that takes place. I mentioned in my essay an example of the grand rounds that I attended given by someone in a different specialty who was both a physician and a PhD in biochemistry, and he was talking about prostaglandin metabolism. And talk about a yawner of a title; you almost have to prop your eyelids open with toothpicks. But it turned out to be one of the most fascinating, engaging conversations I've ever encountered. And moreover, it completely opened my eyes to an area of research that I had not been exposed to at all. And it became immediately obvious to me that it was relevant to the area of my interest, which was lung cancer. This individual happened to be just studying colon cancer. He's not an oncologist, but he was studying colon cancer. But it was really interesting what he was talking about. And he made it very relevant to every subspecialist and generalist in the audience because he talked about how prostaglandin has made a difference in various aspects of human physiology.  The other grand rounds which always sticks in my mind was presented by a long standing program director at my former institution of Vanderbilt. He's passed away many years ago, but he gave a fascinating grand rounds where he presented the case of a homeless person. I can't remember the title of his grand rounds exactly, but I think it was “Care of the Homeless” or something like that. So again, not something that necessarily had people rushing to the audience. What he did is he presented this case as a mysterious case, you know, “what is it?” And he slowly built up the presentation of this individual who repeatedly came to the emergency department for various and sundry complaints. And to make a long story short, he presented a case that turned out to be lead poisoning. Everybody was on the edge of their seat trying to figure out what it was. And he was challenging members of the audience and senior members of the audience, including the Cair, and saying, “What do you think?” And it turned out that the patient became intoxicated not by eating paint chips or drinking lead infused liquids. He was burning car batteries to stay alive and inhaling lead fumes, which itself was fascinating, you know, so it was a fabulous grand rounds. And I mean, everybody learned something about the disease that they might otherwise have ignored, you know, if it'd been a title “Lead Poisoning”, I'm not sure a lot of people would have shown up. Dr. Mikkael Sekeres That story, David, reminds me of Tracy Kidder, who's a master of the nonfiction narrative, will choose a subject and kind of just go into great depth about it, and that subject could be a person. And he wrote a book called Rough Sleepers about Jim O'Connell - and Jim O'Connell was one of my attendings when I did my residency at Mass General - and about his life and what he learned about the homeless. And it's this same kind of engaging, “Wow, I never thought about that.” And it takes you in a different direction.  And you know, in your essay, you make a really interesting comment. You reflect that subspecialists, once eager to share their insight with the wider medical community, increasingly withdraw to their own specialty specific conferences, further fragmenting the exchange of knowledge across disciplines. How do you think this affects their ability to gain new insights into their research when they hear from a broader audience and get questions that they usually don't face, as opposed to being sucked into the groupthink of other subspecialists who are similarly isolated? Dr. David Johnson That's one of the reasons I chose to illustrate that prostaglandin presentation, because again, that was not something that I specifically knew much about. And as I said, I went to the grand rounds more out of a sense of obligation than a sense of engagement. Moreover, our Chair at that institution forced us to go, so I was there, not by choice, but I'm so glad I was, because like you say, I got insight into an area that I had not really thought about and that cross pollination and fertilization is really a critical aspect. I think that you can gain at a broad conference like Medical Grand Rounds as opposed to a niche conference where you're talking about APL. You know, everybody's an APL expert, but they never thought about diabetes and how that might impact on their research. So it's not like there's an ‘aha' moment at every Grand Rounds, but I do think that those kinds of broad based audiences can sometimes bring a different perspective that even the speaker, him or herself had not thought of. Dr. Mikkael SekeresI think that's a great place to end and to thank David Johnson, who's a clinical oncologist at the University of Texas Southwestern Medical School and just penned the essay in JCO Art of Oncology Practice entitled "An Oncologist's Guide to Ensuring Your First Medical Grand Rounds Will Be Your Last."  Until next time, thank you for listening to JCO's Cancer Stories: The Art of Oncology. Don't forget to give us a rating or review, and be sure to subscribe so you never miss an episode. You can find all of ASCO's shows at asco.org/podcasts.  David, once again, I want to thank you for joining me today. Dr. David JohnsonThank you very much for having me. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.    Show notes: Like, share and subscribe so you never miss an episode and leave a rating or review.  Guest Bio: Dr David Johnson is a clinical oncologist at the University of Texas Southwestern Medical School.

Tetanus has probably been around for most of human history, or even longer. But it’s preventable today thanks to vaccines. Research: "Emil von Behring." Notable Scientists from 1900 to the Present, edited by Brigham Narins, Gale, 2008. Gale In Context: Science, link.gale.com/apps/doc/K1619001490/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=464250e5. Accessed 17 Apr. 2025. Breasted, J.H., translator. “OIP 3. The Edwin Smith Surgical Papyrus, Volume 1: Hieroglyphic Transliteration, Translation, and Commentary.” Oxford University Press. 1930. Chalian, William. “An Essay on the History of Lockjaw.” Bulletin of the History of Medicine, FEBRUARY, 1940, Vol. 8, No. 2. Via JSTOR. https://www.jstor.org/stable/44446242 Emil von Behring: The founder of serum therapy. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/behring/article/ Galassi, Francesco Maria et al. “Tetanus: historical and palaeopathological aspects considering its current health impact.” Journal of preventive medicine and hygiene vol. 65,4 E580-E585. 31 Jan. 2025, doi:10.15167/2421-4248/jpmh2024.65.4.3376 George, Elizabeth K. “Tetanus (Clostridium tetani Infection).” StatPearls. January 2025. https://www.ncbi.nlm.nih.gov/books/NBK482484/ Hippocrates. “VI. Diseases, Internal Affections.” Harvard University Press. 1988. Jean-Marc Cavaillon, Historical links between toxinology and immunology, Pathogens and Disease, Volume 76, Issue 3, April 2018, fty019, https://doi.org/10.1093/femspd/fty019 Jones CE, Yusuf N, Ahmed B, Kassogue M, Wasley A, Kanu FA. Progress Toward Achieving and Sustaining Maternal and Neonatal Tetanus Elimination — Worldwide, 2000–2022. MMWR Morb Mortal Wkly Rep 2024;73:614–621. DOI: http://dx.doi.org/10.15585/mmwr.mm7328a1 Kaufmann, Stefan H E. “Remembering Emil von Behring: from Tetanus Treatment to Antibody Cooperation with Phagocytes.” mBio vol. 8,1 e00117-17. 28 Feb. 2017, doi:10.1128/mBio.00117-17 Kreston, Rebecca. “Tetanus, the Grinning Death.” Discover. 9/29/2015. https://www.discovermagazine.com/health/tetanus-the-grinning-death Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 14 Apr. 2025. Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 15 Apr. 2025. National Institutes of Health. “Tetanus.” https://history.nih.gov/display/history/Tetanus Ni, Maoshing. “The Yellow Emperor's Classic of Medicine: A New Translation of the Neijing Suwen with Commentary.” Shambhala. 1995. Smithsonian. “The Antibody Initiative: Battling Tetanus.” https://www.si.edu/spotlight/antibody-initiative/battling-tetanus Sundwall, John. “Man and Microbes.” Illustrated lecture given under the auspices of the Kansas Academy of Science, Topeka, January 12, 1917. https://archive.org/details/jstor-3624335/ The Nobel Prize in Physiology or Medicine 1901. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/summary/ Tiwari, Tejpratap S.P. et al. “Chapter 21: Tetanus.” CDC Pink Book. https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-21-tetanus.html Von Behring, Emil and Kitasato Shibasaburo. “The Mechanism of Immunity in Animals to Diphtheria and Tetanus.” Immunology. 1890. http://raolab.org/upfile/file/20200612164743_201234_56288.pdf War Office Committee for the Study of Tetanus. “Memorandum on Tetanus.” Fourth Edition. 1919. https://archive.org/details/b32171201/ World Health Organization. “Tetanus.” 7/12/2024. https://www.who.int/news-room/fact-sheets/detail/tetanus See omnystudio.com/listener for privacy information.

Episode: 1369 Fokker and the machine gun interrupter mechanism.  Today, we meet a nice young man and his killing machines.

En este episodio, profundizamos en uno de los fenómenos más devastadores pero menos comprendidos en neurorrehabilitación: la denervación muscular tras una lesión medular. A través de una revisión exhaustiva de la literatura científica y de la experiencia clínica, abordamos qué ocurre realmente con los músculos que han perdido su inervación, cómo se transforman con el tiempo y qué posibilidades tenemos para intervenir. Hablamos sobre neurofisiología, degeneración axonal, fases de la denervación, y cómo la estimulación eléctrica —especialmente con pulsos largos— puede modificar el curso degenerativo incluso años después de la lesión. Exploramos también el Proyecto RISE, los protocolos clínicos actuales y las implicaciones terapéuticas reales de aplicar electroestimulación en músculos completamente denervados. Si trabajas en neurorrehabilitación o te interesa la ciencia aplicada a la recuperación funcional, este episodio es para ti. Referencias del episodio: 1. Alberty, M., Mayr, W., & Bersch, I. (2023). Electrical Stimulation for Preventing Skin Injuries in Denervated Gluteal Muscles-Promising Perspectives from a Case Series and Narrative Review. Diagnostics (Basel, Switzerland), 13(2), 219. https://doi.org/10.3390/diagnostics13020219 (https://pubmed.ncbi.nlm.nih.gov/36673029/). 2. Beauparlant, J., van den Brand, R., Barraud, Q., Friedli, L., Musienko, P., Dietz, V., & Courtine, G. (2013). Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury. Brain : a journal of neurology, 136(Pt 11), 3347–3361. https://doi.org/10.1093/brain/awt204 (https://pubmed.ncbi.nlm.nih.gov/24080153/). 3. Bersch, I., & Fridén, J. (2021). Electrical stimulation alters muscle morphological properties in denervated upper limb muscles. EBioMedicine, 74, 103737. https://doi.org/10.1016/j.ebiom.2021.103737 (https://pubmed.ncbi.nlm.nih.gov/34896792/). 4. Bersch, I., & Mayr, W. (2023). Electrical stimulation in lower motoneuron lesions, from scientific evidence to clinical practice: a successful transition. European journal of translational myology, 33(2), 11230. https://doi.org/10.4081/ejtm.2023.11230 (https://pmc.ncbi.nlm.nih.gov/articles/PMC10388603/). 5. Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364 (Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364). 6. Carlson B. M. (2014). The Biology of Long-Term Denervated Skeletal Muscle. European journal of translational myology, 24(1), 3293. https://doi.org/10.4081/ejtm.2014.3293 (https://pubmed.ncbi.nlm.nih.gov/26913125/). 7. Carraro, U., Boncompagni, S., Gobbo, V., Rossini, K., Zampieri, S., Mosole, S., Ravara, B., Nori, A., Stramare, R., Ambrosio, F., Piccione, F., Masiero, S., Vindigni, V., Gargiulo, P., Protasi, F., Kern, H., Pond, A., & Marcante, A. (2015). Persistent Muscle Fiber Regeneration in Long Term Denervation. Past, Present, Future. European journal of translational myology, 25(2), 4832. https://doi.org/10.4081/ejtm.2015.4832 (https://pubmed.ncbi.nlm.nih.gov/26913148/). 8. Chandrasekaran, S., Davis, J., Bersch, I., Goldberg, G., & Gorgey, A. S. (2020). Electrical stimulation and denervated muscles after spinal cord injury. Neural regeneration research, 15(8), 1397–1407. https://doi.org/10.4103/1673-5374.274326 (https://pubmed.ncbi.nlm.nih.gov/31997798/). 9. Ding, Y., Kastin, A. J., & Pan, W. (2005). Neural plasticity after spinal cord injury. Current pharmaceutical design, 11(11), 1441–1450. https://doi.org/10.2174/1381612053507855 (https://pmc.ncbi.nlm.nih.gov/articles/PMC3562709/). 10. Dolbow, D. R., Bersch, I., Gorgey, A. S., & Davis, G. M. (2024). The Clinical Management of Electrical Stimulation Therapies in the Rehabilitation of Individuals with Spinal Cord Injuries. Journal of clinical medicine, 13(10), 2995. https://doi.org/10.3390/jcm13102995 (https://pubmed.ncbi.nlm.nih.gov/38792536/). 11. Hofer, C., Mayr, W., Stöhr, H., Unger, E., & Kern, H. (2002). A stimulator for functional activation of denervated muscles. Artificial organs, 26(3), 276–279. https://doi.org/10.1046/j.1525-1594.2002.06951.x (https://pubmed.ncbi.nlm.nih.gov/11940032/). 12. Kern, H., Hofer, C., Mödlin, M., Forstner, C., Raschka-Högler, D., Mayr, W., & Stöhr, H. (2002). Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols. Artificial organs, 26(3), 216–218. https://doi.org/10.1046/j.1525-1594.2002.06933.x (https://pubmed.ncbi.nlm.nih.gov/11940016/). 13. Kern, H., Salmons, S., Mayr, W., Rossini, K., & Carraro, U. (2005). Recovery of long-term denervated human muscles induced by electrical stimulation. Muscle & nerve, 31(1), 98–101. https://doi.org/10.1002/mus.20149 (https://pubmed.ncbi.nlm.nih.gov/15389722/). 14. Kern, H., Rossini, K., Carraro, U., Mayr, W., Vogelauer, M., Hoellwarth, U., & Hofer, C. (2005). Muscle biopsies show that FES of denervated muscles reverses human muscle degeneration from permanent spinal motoneuron lesion. Journal of rehabilitation research and development, 42(3 Suppl 1), 43–53. https://doi.org/10.1682/jrrd.2004.05.0061 (https://pubmed.ncbi.nlm.nih.gov/16195962/). 15. Kern, H., Carraro, U., Adami, N., Hofer, C., Loefler, S., Vogelauer, M., Mayr, W., Rupp, R., & Zampieri, S. (2010). One year of home-based daily FES in complete lower motor neuron paraplegia: recovery of tetanic contractility drives the structural improvements of denervated muscle. Neurological research, 32(1), 5–12. https://doi.org/10.1179/174313209X385644 (https://pubmed.ncbi.nlm.nih.gov/20092690/). 16. Kern, H., & Carraro, U. (2014). Home-Based Functional Electrical Stimulation for Long-Term Denervated Human Muscle: History, Basics, Results and Perspectives of the Vienna Rehabilitation Strategy. European journal of translational myology, 24(1), 3296. https://doi.org/10.4081/ejtm.2014.3296 (https://pmc.ncbi.nlm.nih.gov/articles/PMC4749003/). 17. Kern, H., Hofer, C., Loefler, S., Zampieri, S., Gargiulo, P., Baba, A., Marcante, A., Piccione, F., Pond, A., & Carraro, U. (2017). Atrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017. Neurological research, 39(7), 660–666. https://doi.org/10.1080/01616412.2017.1314906 (https://pubmed.ncbi.nlm.nih.gov/28403681/). 18. Kern, H., & Carraro, U. (2020). Home-Based Functional Electrical Stimulation of Human Permanent Denervated Muscles: A Narrative Review on Diagnostics, Managements, Results and Byproducts Revisited 2020. Diagnostics (Basel, Switzerland), 10(8), 529. https://doi.org/10.3390/diagnostics10080529 (https://pubmed.ncbi.nlm.nih.gov/32751308/). 19. Ko H. Y. (2018). Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock. Korean journal of neurotrauma, 14(2), 47–54. https://doi.org/10.13004/kjnt.2018.14.2.47 (https://pubmed.ncbi.nlm.nih.gov/30402418/). 20. Mittal, P., Gupta, R., Mittal, A., & Mittal, K. (2016). MRI findings in a case of spinal cord Wallerian degeneration following trauma. Neurosciences (Riyadh, Saudi Arabia), 21(4), 372–373. https://doi.org/10.17712/nsj.2016.4.20160278 (https://pmc.ncbi.nlm.nih.gov/articles/PMC5224438/). 21. Pang, Q. M., Chen, S. Y., Xu, Q. J., Fu, S. P., Yang, Y. C., Zou, W. H., Zhang, M., Liu, J., Wan, W. H., Peng, J. C., & Zhang, T. (2021). Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar. Frontiers in immunology, 12, 751021. https://doi.org/10.3389/fimmu.2021.751021 (https://pubmed.ncbi.nlm.nih.gov/34925326/). 22. Schick, T. (Ed.). (2022). Functional electrical stimulation in neurorehabilitation: Synergy effects of technology and therapy. Springer. https://doi.org/10.1007/978-3-030-90123-3 (https://link.springer.com/book/10.1007/978-3-030-90123-3). 23. Swain, I., Burridge, J., & Street, T. (Eds.). (2024). Techniques and technologies in electrical stimulation for neuromuscular rehabilitation. The Institution of Engineering and Technology. https://shop.theiet.org/techniques-and-technologies-in-electrical-stimulation-for-neuromuscular-rehabilitation 24. van der Scheer, J. W., Goosey-Tolfrey, V. L., Valentino, S. E., Davis, G. M., & Ho, C. H. (2021). Functional electrical stimulation cycling exercise after spinal cord injury: a systematic review of health and fitness-related outcomes. Journal of neuroengineering and rehabilitation, 18(1), 99. https://doi.org/10.1186/s12984-021-00882-8 (https://pubmed.ncbi.nlm.nih.gov/34118958/). 25. Xu, X., Talifu, Z., Zhang, C. J., Gao, F., Ke, H., Pan, Y. Z., Gong, H., Du, H. Y., Yu, Y., Jing, Y. L., Du, L. J., Li, J. J., & Yang, D. G. (2023). Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review. Frontiers in nutrition, 10, 1099143. https://doi.org/10.3389/fnut.2023.1099143 (https://pubmed.ncbi.nlm.nih.gov/36937344/). 26. Anatomical Concepts: https://www.anatomicalconcepts.com/articles

In this informative discussion, Dr. Jill Carnahan and Brian Tuckey explore how Fascial Counterstrain can provide relief and healing by addressing the fascial systems within the body. Discover how this technique uniquely targets the arterial, venous, visceral, neural, lymphatic, and musculoskeletal components to alleviate chronic pain, inflammation, and improve function.  Key Concepts/Questions:

What if consciousness isn't just a byproduct of the brain—but the very foundation of reality itself? In this mind-expanding episode, Dr. Tony Nader—a neuroscientist, spiritual teacher, and global leader of the Transcendental Meditation movement—takes us on a journey into the depths of human awareness. He shares how the simple, yet profound, practice of Transcendental Meditation can help you access a state beyond surface thoughts—what he calls pure consciousness—where peace, clarity, and creativity naturally arise. We explore how meditation affects brain coherence, reduces stress, and can even create ripple effects in society through what Dr. Nader calls collective neuroscience.Can a consistent meditation practice actually lead to a higher state of being—what some might call cosmic consciousness? What if deep rest through meditation could be even more rejuvenating than sleep? This conversation will stretch the way you think about the mind, your connection to the universe, and the true purpose of life. Whether you're new to meditation or have been on the path for years, this episode offers powerful insights into how you can tap into your truest self—and contribute to greater harmony in the world around you.Ways to Connect with Dr. Nader:Dr Tony Nader's Website - drtonynader.comTranscendental Meditation - tm.org Maharishi International University - https://www.miu.edu/Dr. Tony Nader: Bridging Science and SpiritualityDr. Tony Nader is a renowned leader in consciousness and human potential, uniquely blending the worlds of science and spirituality. A Harvard-trained physician and MIT neuroscientist, Dr. Nader serves as the global head of the Transcendental Meditation® (TM) organization, guiding over 120 nonprofit institutions worldwide. As the successor to Maharishi Mahesh Yogi, he has expanded access to meditation through both traditional and innovative digital platforms, impacting millions globally.A New York Times bestselling author, Dr. Nader's latest book, Consciousness Is All There Is, explores the fundamental nature of reality through the lens of Vedic wisdom and quantum mechanics. His groundbreaking research links human physiology to ancient texts, offering new insights into the mind-body connection.As President of Maharishi International University and Maharishi University of Management in the Netherlands, Dr. Nader promotes a consciousness-based approach to education. He has delivered thought-provoking talks at institutions like Stanford, the United Nations, and corporate giants like Google and Merrill Lynch.Through his pioneering work, Dr. Nader continues to inspire personal growth and transformation, empowering individuals to unlock their full potential by harmonizing the wisdom of the East with the rigor of modern science.Chapters00:00 Introduction to Dr. Tony Nader02:25 The Journey of Understanding Human Behavior08:29 Transcendental Meditation Explained13:38 Inspiration to Practice Meditation17:54 The Mechanism of Transcendental Meditation22:30 Consciousness and Its Connection to the Universe32:35 The Science of Collective Neuroscience34:28 Understanding Consciousness: A Spectrum37:11 Transcendental Meditation: Awakening Consciousness40:16 The Benefits of Transcendental Meditation45:03 Cosmic Consciousness: A Higher State of Being47:14 The Systematic Path to Transcendence53:32 Life's Purpose: Growth in Consciousness

Axiom Spring Sale - code SARAHSPRING - https://axiomh2.com/ref/6/Holy Hydrogen Code SARAHK - https://holyhydrogen.com/SARAHKHydration Mastery - 40% off - https://www.sarahkleinerwellness.com/offers/HPoqzjZd?coupon_code=MEMBERDISGLP 1 video - https://youtu.be/0LiVR04RzZ4?si=a1wK7VKNl_LR4FrKMy son's eczema story - https://youtu.be/MAIwDmW3Kis?si=RhMRjby5enwT1gUAMy Article diving into the science of hydrogen and why it is not dangerous - https://sarahkleinerwellness.kit.com/posts/is-hydrogen-therapy-dangerous-new-video?_gl=1*o43d6u*_gcl_au*MTQ2NDIwNTU2MC4xNzQzNTE2NjMyTimestamps: 00:00 — Introduction to Hydrogen Therapy02:48 — Personal Journey with Hydrogen Therapy06:07 — Understanding Hydrogen's Mechanism of Action09:03 — Family Protocols and Experiences with Hydrogen11:50 — Scientific Evidence and Safety of Hydrogen Therapy15:09 — Conclusion of the collection of Scientific evidence Video 2 interview with Mateo (starting at 24:30):24:30 — Introduction to Mateo & Airplane travel with Hydrogen31:08 — Hydrogen Water Bottle Features and Maintenance33:40 — Hydrogen Therapy and EMF Protection36:32 — Hydrogen Saturation and Testing Methods39:22 — Hydrogen for Gut Health and Immune Support42:39 — Hydrogen Therapy for Autoimmune Conditions45:33 — Customer Support - How to contact Axiom with questions and get supportThis video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!

From the world of variety to the West End stage, Brian Conley has built a career around his infectious energy, unique humour, and remarkable talent. In this episode of Full Disclosure, Brian opens up about his journey, from growing up in a working-class family to finding solace and confidence in showbiz. He reflects on the highs of performing with legends like Tom Jones to his struggles with dyslexia and alcohol. With his trademark wit, Brian shares how his love for comedy, musicals, and warm-up performances led to a stellar career, while touching on the personal challenges that shaped him along the way. Insightful, raw, and full of laughter, Brian's story is a testament to resilience and the power of finding your true calling.You can buy tickets to The Prat Pack tour here

In this episode, the Surgical Endoscopy team, accompanied by Chief Medical Officer Dr. Brian Dunkin of Boston Scientific, review primary and revisional endoscopic treatment options for bariatric patients. They focus on the emerging data available for procedures such as endoscopic sleeve gastroplasty (ESG) and endoscopic gastrojejunal revision (EGJR) and offer technical tips on how to perform the procedures. In addition, they discuss accessibility challenges for patients and provide insight into the future direction of bariatric endoscopy as a field.  Hosts: ·      Dr. Sullivan “Sully” Ayuso, Minimally Invasive Surgery, Endeavor Health (Evanston, IL), @SAyusoMD (Twitter) ·      Dr. Trevor Crafts, Minimally Invasive Surgeon, Rocky Mountain VA Medical Center (Denver, CO), @CraftsTrevor (Twitter)  ·      Dr. H. Masson Hedberg, Minimally Invasive Surgeon, Endeavor Health (Evanston, IL) ·      Dr. Michael Ujiki, Professor and Louis Biegler Chair of Surgery, Endeavor Health (Evanston, IL), @UjikiMike ·      Dr. Brian Dunkin, Chief Medical Officer at Boston Scientific, @briandunkinmd Learning Objectives:  -       Identify and Describe Common Endobariatric Procedures: Learners will be able to name and briefly describe at least three common endobariatric procedures discussed in the episode, including Endoscopic Sleeve Gastroplasty (ESG), Endoscopic GJ Revisions (Transoral Outlet Reduction - TORR/EGJR), and Intragastric Balloons, along with their historical context and evolution. -       Explain the Mechanism and Benefits of Endoscopic Sleeve Gastroplasty (ESG): Learners will be able to articulate the procedural technique of ESG, including the U-shaped suture pattern, its impact on gastric volume reduction, and the proposed mechanisms of weight loss, such as slowed gastric emptying and hormonal changes, as compared to laparoscopic sleeve gastrectomy. -       Discuss the Role of Technology and Training in Endobariatrics: Learners will be able to explain the significance of endoscopic suturing devices like the Overstitch in the advancement of endobariatric procedures and recognize the importance of specialized training, including the recommendations against fundal suturing for safety during the initial learning curve. -       Compare and Contrast Endobariatric Procedures with Surgical and Pharmacological Obesity Treatments: Learners will be able to discuss the position of endobariatric procedures as a "gap therapy" in the spectrum of obesity treatments, highlighting their benefits such as reduced invasiveness, lower complication rates, faster recovery, and increased patient access compared to surgery, as well as their potential role in conjunction with pharmacologic therapies like GLP-1 agonists. -       Recognize Key Considerations and Potential Complications of Endobariatric Procedures: Learners will be able to identify important technical considerations during ESG, such as achieving full-thickness bites while avoiding injury to adjacent organs, and describe common post-procedure issues associated with intragastric balloons, including nausea, vomiting, and the need for general anesthesia during removal. Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity: https://pubmed.ncbi.nlm.nih.gov/39888616/ Surgical Endoscopy Series Ep. 1: An Introduction to Surgical Endoscopy: https://app.behindtheknife.org/podcast/surgical-endoscopy-series-ep-1-an-introduction-to-surgical-endoscopy Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Featuring a slide presentation and related discussion from Dr Adam M Brufsky, including the following topics: Mechanism of action of and long-term data with CDK4/6 inhibitors in the management of metastatic breast cancer (mBC) (0:00) Comparing safety profiles of CDK4/6 inhibitors (9:49) Role of CDK4/6 inhibitors in therapy for older patients with mBC (24:06) Real-world evidence with CDK4/6 inhibitors (27:31) CME information and select publications

This week on Horror Joy, Brian and Jeff welcome New York Times best-selling author Stephen Graham Jones to the show. We'll be discussing his incredible new novel, "The Buffalo Hunter, Hunter," and delving into the intricate themes it explores:Community, Inherited Guilt, Justice, and the Construction of Truth: We examine how these complex societal issues are portrayed within the narrative of "The Buffalo Hunter, Hunter," and consider the unique lens that horror fiction offers for exploring these themes.The Relationship Between Joy and Horror in Storytelling: We'll explore the nuanced ways in which seemingly disparate emotions like joy and horror can coexist and even enhance the storytelling experience, creating deeper resonance with the audience.The Complexities of Vampires and Slashers: We'll analyze the enduring appeal of these iconic figures in the horror genre, discussing their multifaceted representations and the cultural anxieties they often reflect.The Significance of Community Among Horror Creators and Fans: We'll discuss the vital role of community within the horror landscape, highlighting the support, inspiration, and connection it fosters for both creators and enthusiasts.In addition to discussing his latest work, Stephen will share his perspectives on writing, his enthusiasm for basketball, and some recent horror narratives that he have brought him joy.So grab a slice of your favorite confessional cake and join us as we talk horror, joy, and everything in between with Stephen Graham Jones. Be sure to keep your lanterns lit and your senses alert lest the vampire come for you in the darkness. Ahh ZombiesHi-Phi Nation – VampiresVictorian PsychoMaeve Fly by C.J. LeeHappy Death Day directed by Christopher LandonThe Cabin in the WoodsAlso See: A Horror Apocalypse – Meta-Horror, Masks, and The Cabin in the WoodsThe Legend of Beaver DamSpider by Nash Edgerton  00:00 Introduction to Stephen Graham Jones' Latest Novel02:33 Exploring the Relationship Between Joy and Horror05:47 The Concept of Conversion in Vampire Stories08:20 Justice and Inherited Guilt in 'The Buffalo Hunter Hunter'10:34 Ecological Themes and Historical Horror18:07 Confession as a Mechanism for Truth24:12 The Role of Stewardship in the Novel29:04 Stripping Away Community in Horror29:28 The Role of Community in Horror Stories30:42 Crafting Community in Horror Writing32:24 Solidarity Among Horror Authors33:58 Joy in Horror Communities34:38 Exploring Slasher Books36:05 Balancing Inclusivity and In-Jokes40:16 Selling Horror to the Hesitant43:40 The Joy of Horror Storytelling48:24 Basketball and Writing52:23 Final Thoughts and Farewells     

In this conversation, Dr. Riley Kirk and Dr. Josh Kaplan delve into the complexities of cannabis research, particularly focusing on CBD and its therapeutic potential for conditions like epilepsy. Dr. Kaplan shares his journey into cannabis research, highlighting the significance of understanding CBD's mechanisms, the role of GPR55 in seizure management, and the challenges of dosing CBD effectively. They also discuss the entourage effect, the importance of personalized medicine, and the ongoing research into terpenes and their interactions with cannabinoids. The conversation emphasizes the need for further exploration in cannabis research to develop safe and effective therapies, especially for vulnerable populations like children. In this conversation, Josh Kaplan discusses the therapeutic potential of CBD, particularly in relation to traumatic brain injuries and neurodegenerative diseases. He emphasizes the safety of CBD compared to THC and explores its role in preventative treatments. The conversation also delves into ongoing clinical trials, particularly within the NFL, and the challenges faced in cannabis research, including dosing and the variability of individual responses to cannabinoids. Kaplan highlights the importance of understanding the entourage effect and the need for more personalized approaches in cannabis treatment. More about Dr. Kaplan: Dr. Kaplan is an Associate Professor in the Behavioral Neuroscience Program. His expertise is in neurophysiology, neuropharmacology, and animal behavior techniques, which his lab uses to study the therapeutic benefits and developmental consequences of cannabis in pre-clinical rodent models. His research seeks to optimize cannabinoid and terpene compositions to maximize benefit and minimize adverse consequences.  Dr. Kaplan has a strong passion for teaching and communicating science. His scientific writing specializes in the science of cannabis and its medicinal utility. He was included in High Times' 100 Most Influential People in Cannabis (2018) and Cannabis Newsletter's Top 100 (2021). Follow Dr.Kaplan's research: https://wp.wwu.edu/kaplanlab/ Preorder my book Reefer Wellness! https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156 Seed Giveaway Thank you to Royal Queen Seeds and Last Green Valley Seeds for donating to this week's giveaway! To enter, fill out the form below, winners will be selected at random.  https://forms.gle/1vWtsBMGaux9x5Mf6 ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one. www.Patreon.com/Cannabichem

NBN host Hollay Ghadery speaks with cultural icons, Anne Waldman (The Iovis Trilogy: Colors in the Mechanism of Concealment) and Andrew Whiteman (Broken Social Scene) who have collaborated to create Your Devotee in Rags—a metamorphic sonic poetry LP released by Siren Recordings in 2025 and is available from Spotify. The conversation starts with a discussion of Anne's epic, The Iovis Trilogy (Coffee House Press, 2011). Published for the first time in its entirety, this major epic poem assures Anne Waldman's place in the pantheon of contemporary poetry. The Iovis Trilogy, Waldman's monumental feminist epic, traverses epochs, cultures, and genres to create a visionary call to poetic arms. Iovis details the misdeeds of the Patriarch, and with a fierce imagination queries and subverts his warmongering. All of Waldman's themes come into focus—friendship, motherhood, politics, and Buddhist wisdom. This is epic poetry that goes beyond the old injunction “to include history”—its effort is to change history. Your Devotee in Rags is a missive to this age of patriarchal power, its songs and poems are designed to specifically confront that power and hold it to account. Taking such activist inspiration from musicians like Lido Pimienta and Tanya Tagaaq, musically YDIR blends acoustic and electronic genres, waltzes, laments, and Pauls Boutique-era Beastie Boys mash-ups all with the intent of creating a new artistic headspace: sonic poetry. The cultural direction is forward, the earbuds open up the stereo field, listening to YDIR is, in a word, empowering. More about Your Devotee in Rags: Your Devotee in Rags is a sonic poetry collaboration between Anne Waldman and Andrew Whiteman; an act of desire and metamorphosis expanding the performative vision of being at the horizon of new experience, stripped down, exploring the turf, through poetry and spiritual yearning. Anne says: “Wizard Hal Willner would be proud of us companions in the vibrational matrix. Comrades in a studio of subtle suspense, and where were we headed? A magnificent voyage! Tender, rugged, true. I met Andrew Whiteman, genius player, composer, scholar, in one of Hal's unpredictable alchemical laboratories. We instantly bonded as mavens of poetry and its attendant orality, dedicated to the passion of epic life that is the source of this album, the 1000 plus pages of the feminist canto: Iovis Trilogy: Colors in the Mechanism of Concealment; passages plucked to be re-imagined in ambient explosive word-sound. On the Yantzse, in a strip club, a maelstrom of memory honoring precursor male poets, dressed in the rags of Celtic hags, so much more as mendicant, witty siren, compassionate lover, exploding empires of patriarchy and war. A kind of mythic hospitality.” Andrew says: “It was filmmaker Ron Mann and producer Hal Wilner who showed me the way. Hal was my guiding presence—whip smart, funny, gentle, empathic. This album is dedicated to him.” More about Anne Waldman: Anne Waldman is a living legend. Poet, performer, professor, editor, cultural activist, grandmother, and co-founder with Allen Ginsberg of the Jack Kerouac School of Disembodied Poetics. Former director of the Poetry Project. Tireless author of over 40 books, her trademark energy coils ever outward, always seeking to reveal the four-fold vision that we have largely lost. More about Andrew Whiteman: Andrew Whiteman is a musician and mythopoetics scholar from Montreal, Canada. He writes and performs in Broken Social Scene, Apostle of Hustle, AroarA, and Poets' Workout Sound System. He is a co-founder of Siren Recordings. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/poetry

Summary At some point this medication may show its face on the pain boards.  Whether or not Suzetrigine will appear on the pain boards, all of us need to know about this new class of analgesic. Brought to you by NRAP Academy, home of the PainExam Board Prep Here, Dr. David Rosenblum delivered a comprehensive lecture about a new pain medication called Journavx (Suzetrigine). He discussed its mechanism of action as a NAV 1.8 receptor inhibitor, its clinical applications, contraindications, and dosing guidelines. Dr. Rosenblum emphasized that this non-opioid medication represents a new class of pain management drugs with no addiction potential. He also shared information about upcoming educational events, including ultrasound courses and various pain management conferences. The lecture included detailed information about drug interactions, safety considerations, and clinical trial results comparing Journavx to placebo and hydrocodone-acetaminophen combinations. Key findings from clinical trials showed that Jornavix achieved pain relief in 119 minutes compared to 480 minutes for placebo in abdominoplasty trials, and 240 minutes versus 480 minutes in bunionectomy trials. The recommended dosing is 50mg tablets twice daily, with an initial loading dose of 100mg. While the drug showed promising results for moderate to severe acute pain management, it did not demonstrate superiority over hydrocodone in clinical trials. Important contraindications include CYP3A inhibitors, and special considerations are needed for patients with hepatic impairment or those taking hormonal contraceptives. The medication should be taken on an empty stomach, either one hour before or two hours after food, and patients should avoid grapefruit juice while on this medication. For more infomation.... Chapters Introduction and Upcoming Events Dr. Rosenblum announced several upcoming events, including an ultrasound course in New York City on May 17th, 2025. He mentioned offering ultrasound and IV training for healthcare professionals, particularly nurses, ICUs, PAs, and hospital doctors. He also highlighted upcoming conferences including ASPN, Pain Week, Latin American Pain Society, New York, New Jersey Pain Congress, ASIPP, and EPA. Introduction to Journavx (Suzetrigine) Dr. Rosenblum introduced Suzetrigine (Journavx), a new 50mg tablet medication. He emphasized that this discussion was not sponsored by any pharmaceutical company but rather focused on educating about a new class of pain medication. He noted its potential importance as a future board examination topic. Mechanism of Action Dr. Rosenblum explained that Jornavx works by inhibiting the NAV 1.8 receptor. He detailed how the drug blocks sodium ions from entering pain-sensing neurons, disrupting action potential initiation and propagation. He emphasized that the drug is highly selective, binding over 31,000 times more selectively to NAV 1.8 than other NAV subtypes. Contraindications and Drug Interactions Dr. Rosenblum outlined various contraindications, particularly focusing on CYP3A inhibitors and inducers. He listed specific medications in each category and emphasized the importance of careful monitoring when prescribing Journavx alongside these medications. Clinical Trial Results and Dosing Guidelines Dr. Rosenblum presented clinical trial results showing Journavx's effectiveness in treating moderate to severe acute pain. He detailed the dosing guidelines: 50mg tablets twice daily, with an initial loading dose of 100mg. He emphasized the importance of taking the medication on an empty stomach and avoiding grapefruit juice. Q&A No Q&A session in this lecture

Summary At some point this medication may show its face on the Anesthesia boards.  Whether or not Suzetrigine will appear on the Anesthesiology boards, all of us need to know about this new class of analgesic. Brought to you by NRAP Academy, home of the AnesthesiaExam Board Prep Here, Dr. David Rosenblum delivered a comprehensive lecture about a new pain medication called Journavx (Suzetrigine). He discussed its mechanism of action as a NAV 1.8 receptor inhibitor, its clinical applications, contraindications, and dosing guidelines. Dr. Rosenblum emphasized that this non-opioid medication represents a new class of pain management drugs with no addiction potential. He also shared information about upcoming educational events, including ultrasound courses and various pain management conferences. The lecture included detailed information about drug interactions, safety considerations, and clinical trial results comparing Journavx to placebo and hydrocodone-acetaminophen combinations. Key findings from clinical trials showed that Jornavix achieved pain relief in 119 minutes compared to 480 minutes for placebo in abdominoplasty trials, and 240 minutes versus 480 minutes in bunionectomy trials. The recommended dosing is 50mg tablets twice daily, with an initial loading dose of 100mg. While the drug showed promising results for moderate to severe acute pain management, it did not demonstrate superiority over hydrocodone in clinical trials. Important contraindications include CYP3A inhibitors, and special considerations are needed for patients with hepatic impairment or those taking hormonal contraceptives. The medication should be taken on an empty stomach, either one hour before or two hours after food, and patients should avoid grapefruit juice while on this medication. For more infomation.... Chapters Introduction and Upcoming Events Dr. Rosenblum announced several upcoming events, including an ultrasound course in New York City on May 17th, 2025. He mentioned offering ultrasound and IV training for healthcare professionals, particularly nurses, ICUs, PAs, and hospital doctors. He also highlighted upcoming conferences including ASPN, Pain Week, Latin American Pain Society, New York, New Jersey Pain Congress, ASIPP, and EPA. Introduction to Journavx (Suzetrigine) Dr. Rosenblum introduced Suzetrigine (Journavx), a new 50mg tablet medication. He emphasized that this discussion was not sponsored by any pharmaceutical company but rather focused on educating about a new class of pain medication. He noted its potential importance as a future board examination topic. Mechanism of Action Dr. Rosenblum explained that Jornavx works by inhibiting the NAV 1.8 receptor. He detailed how the drug blocks sodium ions from entering pain-sensing neurons, disrupting action potential initiation and propagation. He emphasized that the drug is highly selective, binding over 31,000 times more selectively to NAV 1.8 than other NAV subtypes. Contraindications and Drug Interactions Dr. Rosenblum outlined various contraindications, particularly focusing on CYP3A inhibitors and inducers. He listed specific medications in each category and emphasized the importance of careful monitoring when prescribing Journavx alongside these medications. Clinical Trial Results and Dosing Guidelines Dr. Rosenblum presented clinical trial results showing Journavx's effectiveness in treating moderate to severe acute pain. He detailed the dosing guidelines: 50mg tablets twice daily, with an initial loading dose of 100mg. He emphasized the importance of taking the medication on an empty stomach and avoiding grapefruit juice. Q&A No Q&A session in this lecture

  Summary At some point this medication may show its face on the Physiatry boards.  Whether or not Suzetrigine will appear on the Physical Medicine and Rehabilitation boards, all of us need to know about this new class of analgesic. Brought to you by NRAP Academy, home of the PMRExam Board Prep Here, Dr. David Rosenblum delivered a comprehensive lecture about a new pain medication called Journavx (Suzetrigine). He discussed its mechanism of action as a NAV 1.8 receptor inhibitor, its clinical applications, contraindications, and dosing guidelines. Dr. Rosenblum emphasized that this non-opioid medication represents a new class of pain management drugs with no addiction potential. He also shared information about upcoming educational events, including ultrasound courses and various pain management conferences. The lecture included detailed information about drug interactions, safety considerations, and clinical trial results comparing Journavx to placebo and hydrocodone-acetaminophen combinations. Key findings from clinical trials showed that Jornavix achieved pain relief in 119 minutes compared to 480 minutes for placebo in abdominoplasty trials, and 240 minutes versus 480 minutes in bunionectomy trials. The recommended dosing is 50mg tablets twice daily, with an initial loading dose of 100mg. While the drug showed promising results for moderate to severe acute pain management, it did not demonstrate superiority over hydrocodone in clinical trials. Important contraindications include CYP3A inhibitors, and special considerations are needed for patients with hepatic impairment or those taking hormonal contraceptives. The medication should be taken on an empty stomach, either one hour before or two hours after food, and patients should avoid grapefruit juice while on this medication. For more infomation.... Chapters Introduction and Upcoming Events Dr. Rosenblum announced several upcoming events, including an ultrasound course in New York City on May 17th, 2025. He mentioned offering ultrasound and IV training for healthcare professionals, particularly nurses, ICUs, PAs, and hospital doctors. He also highlighted upcoming conferences including ASPN, Pain Week, Latin American Pain Society, New York, New Jersey Pain Congress, ASIPP, and EPA. Introduction to Journavx (Suzetrigine) Dr. Rosenblum introduced Suzetrigine (Journavx), a new 50mg tablet medication. He emphasized that this discussion was not sponsored by any pharmaceutical company but rather focused on educating about a new class of pain medication. He noted its potential importance as a future board examination topic. Mechanism of Action Dr. Rosenblum explained that Jornavx works by inhibiting the NAV 1.8 receptor. He detailed how the drug blocks sodium ions from entering pain-sensing neurons, disrupting action potential initiation and propagation. He emphasized that the drug is highly selective, binding over 31,000 times more selectively to NAV 1.8 than other NAV subtypes. Contraindications and Drug Interactions Dr. Rosenblum outlined various contraindications, particularly focusing on CYP3A inhibitors and inducers. He listed specific medications in each category and emphasized the importance of careful monitoring when prescribing Journavx alongside these medications. Clinical Trial Results and Dosing Guidelines Dr. Rosenblum presented clinical trial results showing Journavx's effectiveness in treating moderate to severe acute pain. He detailed the dosing guidelines: 50mg tablets twice daily, with an initial loading dose of 100mg. He emphasized the importance of taking the medication on an empty stomach and avoiding grapefruit juice. Q&A No Q&A session in this lecture

Featuring an interview with Dr Raajit K Rampal, including the following topics: Clinical decision-making in the initiation and stopping of systemic therapy for myelofibrosis (MF) (0:00) Novel research strategies involving CDK4/6 inhibitors for MF (8:03) Implications of the JUMP study for clinical practice (10:00) Therapeutic switching strategies with JAK inhibitors for MF (12:17) Clinical rationale for the use of luspatercept and elritercept for MF (15:35) Emerging clinical data involving BET inhibitors for MF (16:57) Tolerability concerns with selinexor in patients with MF (20:01) Mechanism of and clinical data with the MDM2 inhibitor navtemadlin for MF (22:32) Additional novel strategies under clinical investigation for MF (25:52) Potential transformation of myeloproliferative neoplasms to acute myeloid leukemia (29:40) Management of polycythemia vera and essential thrombocythemia (34:27) General management principles for myeloproliferative neoplasms (37:53) CME information and select publications

NBN host Hollay Ghadery speaks with cultural icons, Anne Waldman (The Iovis Trilogy: Colors in the Mechanism of Concealment) and Andrew Whiteman (Broken Social Scene) who have collaborated to create Your Devotee in Rags—a metamorphic sonic poetry LP released by Siren Recordings in 2025 and is available from Spotify. The conversation starts with a discussion of Anne's epic, The Iovis Trilogy (Coffee House Press, 2011). Published for the first time in its entirety, this major epic poem assures Anne Waldman's place in the pantheon of contemporary poetry. The Iovis Trilogy, Waldman's monumental feminist epic, traverses epochs, cultures, and genres to create a visionary call to poetic arms. Iovis details the misdeeds of the Patriarch, and with a fierce imagination queries and subverts his warmongering. All of Waldman's themes come into focus—friendship, motherhood, politics, and Buddhist wisdom. This is epic poetry that goes beyond the old injunction “to include history”—its effort is to change history. Your Devotee in Rags is a missive to this age of patriarchal power, its songs and poems are designed to specifically confront that power and hold it to account. Taking such activist inspiration from musicians like Lido Pimienta and Tanya Tagaaq, musically YDIR blends acoustic and electronic genres, waltzes, laments, and Pauls Boutique-era Beastie Boys mash-ups all with the intent of creating a new artistic headspace: sonic poetry. The cultural direction is forward, the earbuds open up the stereo field, listening to YDIR is, in a word, empowering. More about Your Devotee in Rags: Your Devotee in Rags is a sonic poetry collaboration between Anne Waldman and Andrew Whiteman; an act of desire and metamorphosis expanding the performative vision of being at the horizon of new experience, stripped down, exploring the turf, through poetry and spiritual yearning. Anne says: “Wizard Hal Willner would be proud of us companions in the vibrational matrix. Comrades in a studio of subtle suspense, and where were we headed? A magnificent voyage! Tender, rugged, true. I met Andrew Whiteman, genius player, composer, scholar, in one of Hal's unpredictable alchemical laboratories. We instantly bonded as mavens of poetry and its attendant orality, dedicated to the passion of epic life that is the source of this album, the 1000 plus pages of the feminist canto: Iovis Trilogy: Colors in the Mechanism of Concealment; passages plucked to be re-imagined in ambient explosive word-sound. On the Yantzse, in a strip club, a maelstrom of memory honoring precursor male poets, dressed in the rags of Celtic hags, so much more as mendicant, witty siren, compassionate lover, exploding empires of patriarchy and war. A kind of mythic hospitality.” Andrew says: “It was filmmaker Ron Mann and producer Hal Wilner who showed me the way. Hal was my guiding presence—whip smart, funny, gentle, empathic. This album is dedicated to him.” More about Anne Waldman: Anne Waldman is a living legend. Poet, performer, professor, editor, cultural activist, grandmother, and co-founder with Allen Ginsberg of the Jack Kerouac School of Disembodied Poetics. Former director of the Poetry Project. Tireless author of over 40 books, her trademark energy coils ever outward, always seeking to reveal the four-fold vision that we have largely lost. More about Andrew Whiteman: Andrew Whiteman is a musician and mythopoetics scholar from Montreal, Canada. He writes and performs in Broken Social Scene, Apostle of Hustle, AroarA, and Poets' Workout Sound System. He is a co-founder of Siren Recordings. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

NBN host Hollay Ghadery speaks with cultural icons, Anne Waldman (The Iovis Trilogy: Colors in the Mechanism of Concealment) and Andrew Whiteman (Broken Social Scene) who have collaborated to create Your Devotee in Rags—a metamorphic sonic poetry LP released by Siren Recordings in 2025 and is available from Spotify. The conversation starts with a discussion of Anne's epic, The Iovis Trilogy (Coffee House Press, 2011). Published for the first time in its entirety, this major epic poem assures Anne Waldman's place in the pantheon of contemporary poetry. The Iovis Trilogy, Waldman's monumental feminist epic, traverses epochs, cultures, and genres to create a visionary call to poetic arms. Iovis details the misdeeds of the Patriarch, and with a fierce imagination queries and subverts his warmongering. All of Waldman's themes come into focus—friendship, motherhood, politics, and Buddhist wisdom. This is epic poetry that goes beyond the old injunction “to include history”—its effort is to change history. Your Devotee in Rags is a missive to this age of patriarchal power, its songs and poems are designed to specifically confront that power and hold it to account. Taking such activist inspiration from musicians like Lido Pimienta and Tanya Tagaaq, musically YDIR blends acoustic and electronic genres, waltzes, laments, and Pauls Boutique-era Beastie Boys mash-ups all with the intent of creating a new artistic headspace: sonic poetry. The cultural direction is forward, the earbuds open up the stereo field, listening to YDIR is, in a word, empowering. More about Your Devotee in Rags: Your Devotee in Rags is a sonic poetry collaboration between Anne Waldman and Andrew Whiteman; an act of desire and metamorphosis expanding the performative vision of being at the horizon of new experience, stripped down, exploring the turf, through poetry and spiritual yearning. Anne says: “Wizard Hal Willner would be proud of us companions in the vibrational matrix. Comrades in a studio of subtle suspense, and where were we headed? A magnificent voyage! Tender, rugged, true. I met Andrew Whiteman, genius player, composer, scholar, in one of Hal's unpredictable alchemical laboratories. We instantly bonded as mavens of poetry and its attendant orality, dedicated to the passion of epic life that is the source of this album, the 1000 plus pages of the feminist canto: Iovis Trilogy: Colors in the Mechanism of Concealment; passages plucked to be re-imagined in ambient explosive word-sound. On the Yantzse, in a strip club, a maelstrom of memory honoring precursor male poets, dressed in the rags of Celtic hags, so much more as mendicant, witty siren, compassionate lover, exploding empires of patriarchy and war. A kind of mythic hospitality.” Andrew says: “It was filmmaker Ron Mann and producer Hal Wilner who showed me the way. Hal was my guiding presence—whip smart, funny, gentle, empathic. This album is dedicated to him.” More about Anne Waldman: Anne Waldman is a living legend. Poet, performer, professor, editor, cultural activist, grandmother, and co-founder with Allen Ginsberg of the Jack Kerouac School of Disembodied Poetics. Former director of the Poetry Project. Tireless author of over 40 books, her trademark energy coils ever outward, always seeking to reveal the four-fold vision that we have largely lost. More about Andrew Whiteman: Andrew Whiteman is a musician and mythopoetics scholar from Montreal, Canada. He writes and performs in Broken Social Scene, Apostle of Hustle, AroarA, and Poets' Workout Sound System. He is a co-founder of Siren Recordings. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/literature

NBN host Hollay Ghadery speaks with cultural icons, Anne Waldman (The Iovis Trilogy: Colors in the Mechanism of Concealment) and Andrew Whiteman (Broken Social Scene) who have collaborated to create Your Devotee in Rags—a metamorphic sonic poetry LP released by Siren Recordings in 2025 and is available from Spotify. The conversation starts with a discussion of Anne's epic, The Iovis Trilogy (Coffee House Press, 2011). Published for the first time in its entirety, this major epic poem assures Anne Waldman's place in the pantheon of contemporary poetry. The Iovis Trilogy, Waldman's monumental feminist epic, traverses epochs, cultures, and genres to create a visionary call to poetic arms. Iovis details the misdeeds of the Patriarch, and with a fierce imagination queries and subverts his warmongering. All of Waldman's themes come into focus—friendship, motherhood, politics, and Buddhist wisdom. This is epic poetry that goes beyond the old injunction “to include history”—its effort is to change history. Your Devotee in Rags is a missive to this age of patriarchal power, its songs and poems are designed to specifically confront that power and hold it to account. Taking such activist inspiration from musicians like Lido Pimienta and Tanya Tagaaq, musically YDIR blends acoustic and electronic genres, waltzes, laments, and Pauls Boutique-era Beastie Boys mash-ups all with the intent of creating a new artistic headspace: sonic poetry. The cultural direction is forward, the earbuds open up the stereo field, listening to YDIR is, in a word, empowering. More about Your Devotee in Rags: Your Devotee in Rags is a sonic poetry collaboration between Anne Waldman and Andrew Whiteman; an act of desire and metamorphosis expanding the performative vision of being at the horizon of new experience, stripped down, exploring the turf, through poetry and spiritual yearning. Anne says: “Wizard Hal Willner would be proud of us companions in the vibrational matrix. Comrades in a studio of subtle suspense, and where were we headed? A magnificent voyage! Tender, rugged, true. I met Andrew Whiteman, genius player, composer, scholar, in one of Hal's unpredictable alchemical laboratories. We instantly bonded as mavens of poetry and its attendant orality, dedicated to the passion of epic life that is the source of this album, the 1000 plus pages of the feminist canto: Iovis Trilogy: Colors in the Mechanism of Concealment; passages plucked to be re-imagined in ambient explosive word-sound. On the Yantzse, in a strip club, a maelstrom of memory honoring precursor male poets, dressed in the rags of Celtic hags, so much more as mendicant, witty siren, compassionate lover, exploding empires of patriarchy and war. A kind of mythic hospitality.” Andrew says: “It was filmmaker Ron Mann and producer Hal Wilner who showed me the way. Hal was my guiding presence—whip smart, funny, gentle, empathic. This album is dedicated to him.” More about Anne Waldman: Anne Waldman is a living legend. Poet, performer, professor, editor, cultural activist, grandmother, and co-founder with Allen Ginsberg of the Jack Kerouac School of Disembodied Poetics. Former director of the Poetry Project. Tireless author of over 40 books, her trademark energy coils ever outward, always seeking to reveal the four-fold vision that we have largely lost. More about Andrew Whiteman: Andrew Whiteman is a musician and mythopoetics scholar from Montreal, Canada. He writes and performs in Broken Social Scene, Apostle of Hustle, AroarA, and Poets' Workout Sound System. He is a co-founder of Siren Recordings. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sound-studies

If you've ever felt uncomfortable “selling yourself” — this episode might just change everything. In this episode, Jason Harris, co-founder of the award-winning ad agency Mechanism and author of The Soulful Art of Persuasion, shares how he built a powerhouse business without using manipulation or salesy tactics. Instead, he leaned into empathy, generosity, and storytelling — values most people don't associate with persuasion. We talk about how to lead with integrity, what it really means to influence without forcing, and why your reputation is the most powerful negotiation tool you have. Connect with Jason Buy the book: The Soulful Art of Persuasion Follow Jason on LinkedIn Jason Harris Mekanism Contact ANI Request A Customized Workshop For Your Company Follow Kwame Christian on LinkedIn The Ultimate Negotiation Guide Click here to buy your copy of How To Have Difficult Conversations About Race! Click here to buy your copy of Finding Confidence in Conflict: How to Negotiate Anything and Live Your Best Life!

If you've ever felt uncomfortable “selling yourself” — this episode might just change everything. In this episode, Jason Harris, co-founder of the award-winning ad agency Mechanism and author of The Soulful Art of Persuasion, shares how he built a powerhouse business without using manipulation or salesy tactics. Instead, he leaned into empathy, generosity, and storytelling — values most people don't associate with persuasion. We talk about how to lead with integrity, what it really means to influence without forcing, and why your reputation is the most powerful negotiation tool you have. Connect with Jason Buy the book: The Soulful Art of Persuasion Follow Jason on LinkedIn Jason Harris Mekanism Contact ANI Request A Customized Workshop For Your Company Follow Kwame Christian on LinkedIn The Ultimate Negotiation Guide Click here to buy your copy of How To Have Difficult Conversations About Race! Click here to buy your copy of Finding Confidence in Conflict: How to Negotiate Anything and Live Your Best Life!

Struggling to make sales effortless and create offers your audience can't resist? In this episode, discover the 3-Part Formula for Effortless Sales & Irresistible Offers. Learn how to align your Market, Offer, and Mechanism to boost conversions and build a strategy that works for you.Ready to transform your sales? Listen now!

 What happens when the preventative surgery you chose to avoid cancer reveals you already have it?  In this episode of "Every Soul Has a Story," Dara Levan welcomes author Gila Pfeffer, whose memoir "Nearly Departed" chronicles her journey through losing both parents to cancer at a young age and her own battle with breast cancer. With refreshing candor and signature wit, Gila shares how her Orthodox Jewish identity shaped her experiences and how becoming a mother to four children galvanized her commitment to preventative healthcare - ultimately saving her life when a preventative mastectomy revealed aggressive cancer.  Weaving together themes of resilience, authentic storytelling, and finding humor in life's darkest moments, Gila reflects on the profound significance of reaching age 50 - making her the first woman in four generations of her family to achieve this milestone. Her powerful metaphor of a broken mug still worth saving resonates deeply as she discusses her advocacy work and how sharing her story has inspired countless women to prioritize breast health. Like the cracked vessel on her book cover - weathered yet still holding precious contents - Gila's narrative embodies the beauty of imperfect survival.  Gila Pfeffer is a Jewish American humor writer whose memoir "Nearly Departed" chronicles her journey through loss, cancer, and survival with unflinching candor and unexpected hilarity. A fifteen-year breast cancer previvor and survivor, Gila's "Feel It on the First" campaign has directly led to earlier diagnoses for countless women through its tongue-in-cheek reminders about breast health. As an Orthodox Jewish mother of four who underwent preventative mastectomy at 34 only to discover early-stage cancer, Gila's writing - featured in The New York Times, The New Yorker, and McSweeney's - transforms tragedy into empowerment through her signature wit. She splits her time between London, New York City, and Instagram.  In This Episode:  (00:00) Meet Gila Pfeffer: Author of "Nearly Departed" (05:26) "Making fun of something is taking your power back" (08:12) What does authentic branding really mean? (13:07) Breaking the cycle: First to reach 50 (19:11) The delicate balance of telling your truth in memoir (23:51) How four children saved their mother's life (29:16) Beyond the pink ribbon: Rethinking breast cancer awareness (34:42) One person at a time: The impact of sharing your story (38:45) The metaphor of the broken mug  (39:55) Closing thoughts   Like and subscribe to hear all of our inspirational episodes!  Resources: https://www.gilapfeffer.com/ @GilaPfeffer on Instagram Nearly Departed Sign up for Dara's Newsletter Listen to other podcast episodes Here Connect with Dara on Instagram and Facebook Visit DaraLevan.com 

Dr Tricia Keilthy of the Ombudsman for Children’s Office is urging the government to set up a statutory mechanism for reviewing child deaths to help grieving families get answers. If you have been affected by this, you may contact The Samaritans on 116 123.

We love a good verses episode here at Cardboard Philosophy! Which is exactly what we are diving into this week! Genres verses mechanisms! Which is which? How do we separate them and how do these two words affect the games we know and love? Plus, we put our money where our mouths are and actually use some of these new definitions in the real world! Want to ask a question or give us your two cents about the state of euros? Hit us up at cardboardphilosophypod@gmail.com! Want to play some of Robert's games? Grab them here! - https://www.allplay.com/board-games/partner/bitewing/ Cites and Sources Age of Steam - https://boardgamegeek.com/boardgame/4098/age-of-steam Ark Nova - https://boardgamegeek.com/boardgame/342942/ark-nova Ascension - https://boardgamegeek.com/boardgame/69789/ascension-deckbuilding-game Axis & Allies - https://boardgamegeek.com/boardgame/98/axis-and-allies Brass: Birmingham - https://boardgamegeek.com/boardgame/224517/brass-birmingham Candy Land - https://boardgamegeek.com/boardgame/5048/candy-land Carnegie - https://boardgamegeek.com/boardgame/310873/carnegie Cascadia - https://boardgamegeek.com/boardgame/295947/cascadia Catan - https://boardgamegeek.com/boardgame/13/catan Caylus - https://boardgamegeek.com/boardgame/18602/caylus Checkers - https://boardgamegeek.com/boardgame/2083/checkers Chess - https://boardgamegeek.com/boardgame/171/chess Civolution - https://boardgamegeek.com/boardgame/400602/civolution Cyclades - https://boardgamegeek.com/boardgame/54998/cyclades Dominion - https://boardgamegeek.com/boardgame/36218/dominion Dune - https://boardgamegeek.com/boardgame/283355/dune Dune: Imperium - https://boardgamegeek.com/boardgame/316554/dune-imperium Empires In Arms - https://boardgamegeek.com/boardgame/254/empires-in-arms Gloomhaven - https://boardgamegeek.com/boardgame/174430/gloomhaven Great Western Trail - https://boardgamegeek.com/boardgame/193738/great-western-trail Ingenious - https://boardgamegeek.com/boardgame/9674/ingenious Inis - https://boardgamegeek.com/boardgame/155821/inis Innovation - https://boardgamegeek.com/boardgame/63888/innovation Imperial Steam - https://boardgamegeek.com/boardgame/338760/imperial-steam Jenga - https://boardgamegeek.com/boardgame/2452/jenga Kemet - https://boardgamegeek.com/boardgame/127023/kemet Monopoly - https://boardgamegeek.com/boardgame/1406/monopoly Mexica - https://boardgamegeek.com/boardgame/2955/mexica Pandemic Legacy – Season One - https://boardgamegeek.com/boardgame/161936/pandemic-legacy-season-1 Paths of Glory - https://boardgamegeek.com/boardgame/91/paths-of-glory Power Grid - https://boardgamegeek.com/boardgame/2651/power-grid Quacks - https://boardgamegeek.com/boardgame/244521/quacks Railroad Ink - https://boardgamegeek.com/boardgame/245654/railroad-ink-deep-blue-edition Risk - https://boardgamegeek.com/boardgame/181/risk Root - https://boardgamegeek.com/boardgame/7744/roots Scout - https://boardgamegeek.com/boardgame/291453/scout Spirit Island - https://boardgamegeek.com/boardgame/162886/spirit-island Star Realms - https://boardgamegeek.com/boardgame/147020/star-realms Star Wars: Rebellion - https://boardgamegeek.com/boardgame/187645/star-wars-rebellion Taboo - https://boardgamegeek.com/boardgame/1111/taboo Terraforming Mars - https://boardgamegeek.com/boardgame/167791/terraforming-mars Through The Desert - https://boardgamegeek.com/boardgame/503/through-the-desert Twister - https://boardgamegeek.com/boardgame/5894/twister Twilight Imperium: 4th Edition - https://boardgamegeek.com/boardgame/233078/twilight-imperium-fourth-edition War of the Ring: Second Edition - https://boardgamegeek.com/boardgame/115746/war-of-the-ring-second-edition YINSH - https://boardgamegeek.com/boardgame/7854/yinsh  

We review the origin of the Trump derangement syndrome and the Elon Musk derangement syndrome. Both have to do with the psychological mechanism of projection. A common tactic to avoid understanding one's inner motivations and in particular one's self interest cheating, projection, when gone off the rails can result in violence and war. We review a clip from Academy of Ideas to better understand this important phenomenon.Follow Us:YouTubeTwitterFacebookTumblrAll audio & videos edited by: Jay Prescott VideographyClip Used: Carl Jung, the Shadow, and the Dangers of Psychological ProjectionBy: Academy of Ideas

Niall Muldoon, Ombudsman for Children, is calling for a statutory mechanism to investigate child deaths in Ireland.

00:00 Cold start 01:41 About Allo Capital 02:27 Guest Introduction 05:42 About Mechanism Institute 07:15 DAO Drops 09:53 Importance of On-Chain Mechanism 11:51 Remarks from Allo Books 14:26 Is Web3 Able to Control Nuclear Devices? 16:25 Volatility of DAO Space 17:48 Should We Decentralize Only Where It's Needed? To watch full episode, go to allo.capital and join the allominati.   

Laird and Black discuss the SorareMLB rules that look like a burn mechanism, including why Black thinks it's all dumb.#sorare #fantasysports #cardcollectingFor more Sorare (and non-Sorare) content, join the Sorare with Laird community here

Laird discusses some of the new collection rules for SorareMLB and explains how they would work if implemented for Sorare Football this summer.#sorare #fantasysports #cardcollectingFor more Sorare (and non-Sorare) content, join the Sorare with Laird community here

The Mechanism of Thought Identification Learn more about your ad choices. Visit megaphone.fm/adchoices

First-Ever AI App That Manifests Your Dreams Subconsciously—Download NOW!   http://www.manifesteverythingai.com/manifest-ai   Script To Manifest Your Dreams: www.wesleyvirgin.com   Get ready to meet the king of internet marketing and the overnight millionaire, Wesley Virgin! With over 1 billion views on social media, he's taken the online world by storm. Wesley's known for his knack for making money online and has created some of the most famous programs in the biz, including "Overnight Millionaire," "Genie Script," and "Done for You Affiliate Services."   But that's not all! Wesley also runs the epic "Millionaire in Training" community where thousands of aspiring entrepreneurs gather to learn the secrets of financial success. When he's not busy building wildly profitable online businesses, you can find him living the high life on Instagram @wesleymilliondollarvirgin.   He's not just a show-off though, Wesley takes the time to educate his followers on how to make money fast. With his massive influence and digital mentorship, Wesley is truly a global expert in the online business world. Get ready to learn, laugh, and make some serious cash with Wesley Virgin!

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman explore the complex world of psilocybin, or magic mushrooms. The scientists examine the substance's historical significance and neurobiological mechanisms, while discussing the emerging practice of microdosing and psilocybin's evolving legal status across different jurisdictions. They investigate the potential therapeutic applications of psilocybin for various mental health conditions including depression, anxiety, and PTSD. Throughout the conversation, the experts emphasize contextual factors that influence psychedelic experiences and highlight the critical need for continued research to better understand psilocybin's full therapeutic potential. (00:00) Intro (02:25) Understanding Psilocybin: Definition and Classification (03:51) Historical Context of Psilocybin (10:59) Mechanism of Action: How Psilocybin Works in the Brain (14:58) Microdosing: Trends and Effects (17:00) Legal Status and Policy Changes (33:37) Therapeutic Potential and Research Findings https://www.rand.org/news/press/2024/06/27.html https://www.nature.com/articles/s41429-020-0311-8 https://www.cuttersguide.com/pdf/Periodical-Publications/life-by-time-inc-published-may-13-1957.pdf https://tripsitter.com/magic-mushrooms/legal/ https://www.dea.gov/sites/default/files/2020-06/Psilocybin-2020.pdf https://www.hopkinsmedicine.org/news/newsroom/news-releases/2018/09/reclassification-recommendations-for-drug-in-magic-mushrooms https://pmc.ncbi.nlm.nih.gov/articles/PMC10069558/ https://doi.org/10.1007/s13311-017-0542-y https://doi.org/10.1080/14740338.2022.2047929 https://doi.org/10.2147/DDDT.S443177 https://doi.org/10.1124/jpet.124.002237 https://doi.org/10.3389/fpsyt.2024.1359088 https://doi.org/10.1192/j.eurpsy.2023.1767 https://doi.org/10.1021/acsmedchemlett.0c00048 https://doi.org/10.1177/02698811221092508 https://doi.org/10.1111/jnc.16017 https://doi.org/10.1177/02698811231190858 ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

What if you could increase your energy, improve your focus, and optimize your brain health with just one simple lozenge? Dr. Scott Sherr, an expert in health optimization, joins us on the show once more to discuss methylene blue, a powerful mitochondrial enhancer that has been used for over a century. He explains how this compound boosts cognition, helps fight infections, and even improves endurance for athletes. If you've been feeling sluggish, struggling with brain fog, or looking for a smarter approach to supplements, this episode is packed with science-backed insights you can start using today.How long will you live? Take our quiz today to find out at ageist.com/longevity-quizTroscriptions — Precision, pharmaceutical-grade nootropics for peak performance. Whether you need laser focus, mental clarity, or a boost in cognitive endurance, Troscriptions delivers science-backed results. Use code: AGEIST for 10% off, or click here.Thanks to Our SponsorsTimeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with the code “AGEIST” at TimelineNutrition.com/ageist.BON CHARGE: Harness the power of both infrared and red light therapy in the comfort of your own home with the Red Light Face Mask from BON CHARGE. To try their professional-grade technology for yourself, use the code “AGEIST15” for 15% off sitewide.fatty15: C15:0 is the first essential fatty acid to be discovered in 90 years. fatty15 is on a mission to replenish your C15:0 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter the code “AGEIST” at checkout.Chapters(00:00) Introduction to Methylene Blue(02:24) Methylene Blue's Health Benefits(08:03) The History and Mechanism of Methylene Blue(13:00) Cognitive Effects and Mitochondrial Function(18:20) Dosage and Timing for Methylene Blue(24:17) Practical Applications and Endurance Benefits((35:19) Mitochondrial Health and Aging(37:39) Methylene Blue: A Path to Health Optimization(45:22) Utilizing Methylene Blue for Performance(52:05) Methylene Blue and Red Light Therapy Synergy(58:03) Practical Applications and Future of Methylene BlueKey Moments“Methylene blue works like oxygen in your cells, helping your body produce energy even in low-oxygen environments.”“If you don't have working mitochondria in your brain, you won't have optimal cognitive function.”“Stress, poor sleep, and toxins in our environment are killing our mitochondria—this is why so many people feel tired all the time.”Connect With Dr. Scott Sherr & TroscriptionsWebsiteInstagram (@drscottsherr)TroscriptionsMethylene BlueConnect With AGEISTNewsletterSay hi to the AGEIST team!

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman welcome neuroscientist Dr. Ben Rein to explore the complex world of selective serotonin reuptake inhibitors (SSRIs). The scientists examine how these medications work in the brain, addressing both the supporting evidence for their effectiveness in treating depression and anxiety as well as ongoing controversies in the field. They discuss potential side effects, discontinuation symptoms, and the importance of individualized approaches to medication. The conversation also addresses common misconceptions about SSRIs, including alleged links to violence and cognitive decline, while emphasizing critical evaluation of scientific research on these medications. Throughout the episode, the experts provide a balanced perspective on SSRIs' role in mental health treatment, offering listeners valuable insights into making informed decisions about these widely prescribed medications. (00:00) Intro (05:30) Understanding the Mechanism of SSRIs (11:07) Controversies Surrounding SSRIs (14:39) Evidence Supporting SSRIs for Depression and Anxiety (18:40) Side Effects and Withdrawal from SSRIs (21:19) The Impact of SSRIs on Mental Health (24:33) Understanding SSRI Withdrawal Symptoms (27:31) Debunking Myths: SSRIs and Violence (31:20) SSRIs and Depression: A Complex Relationship (34:32) SSRIs and Cognitive Decline in Dementia (39:42) The Science Behind SSRIs (42:06) Critical Thinking in Science (44:33) The Role of PhDs vs. MDs in Mental Health https://www.cdc.gov/nchs/products/databriefs/db377.htm https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03851-3 https://www.aljazeera.com/news/2025/1/30/fact-check-rfk-jrs-statements-during-senate-confirmation-hearing https://autisticadvocacy.org/2025/02/asan-disappointed-by-robert-f-kennedy-jr-s-confirmation-to-lead-hhs/ https://www.pnas.org/doi/10.1073/pnas.2000804117 https://pmc.ncbi.nlm.nih.gov/articles/PMC4975858 https://pubmed.ncbi.nlm.nih.gov/30479005/ https://onlinelibrary.wiley.com/doi/10.1002/wps.20701 https://www.nature.com/articles/s41386-021-01179-z ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Nina and Becky discuss the complexities of yelling as a parenting strategy, exploring its roots in personal experiences and childhood conditioning. They delve into the psychological mechanisms behind why yelling seems effective, the challenges of breaking the cycle of learned behaviors, and the importance of self-regulation for parents. The discussion highlights the emotional turmoil that can arise during extreme meltdowns and offers practical strategies for parents to manage their own responses while supporting their children. In this conversation, Nina and Becky Jennings explore the complexities of parenting, particularly focusing on the impact of yelling and the importance of emotional regulation. They discuss different types of yelling, the psychological effects on children, and strategies for parents to unlearn yelling behaviors. The conversation emphasizes the significance of repairing relationships after conflicts and how to communicate effectively with children. Becky shares practical tips for parents to visualize their responses and practice skills in calm moments, fostering a supportive environment for both parents and children. 00:00: The Yelling Journey: A Personal Reflection 05:01: Understanding the Mechanism of Yelling 10:09: The Challenge of Breaking Patterns 15:09: Navigating Extreme Meltdowns 20:00: Regulating Ourselves as Parents 25:54: Understanding Yelling: Types and Effects 39:03: Unlearning Yelling: Strategies for Parents 47:03: The Importance of Repairing Relationships 53:02: Connecting with Becky: Resources and Community Becky Jennings, is the mom of 3 boys: 2 of which she has the privilege of raising and 1 who she lost in labor and delivery - her son Jackson was the catalyst to her entire healing journey and why she is here today. She is a mom to an ADHD child, parent coach, founder of ResponseABLE Parenting, where she helps parents understand their triggers so they can go from reacting to the chaos of parenting to responding with aligned intention. She lives in Los Angeles, loves cooking but hates meal planning, loves reading but mostly listens on Audible, she is both a pragmatist and very woo woo, driven by her passion to connect with others and to support her children in ways she could have only dreamed of as a kid. Episode Sponsor: Eat smart with Factor. Get started at factormeals.com/factorpodcast and use code FACTORPODCAST to get 50% off your first box plus free shipping on your first box! Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. Stephen Hussey challenges the mainstream view of heart health, explaining why the heart is not a pump and how blood actually moves through the body. He explores the real causes of heart disease, the impact of structured water on vascular health, and how the heart influences the human biofield and soul connection. Dr. Hussey also discusses the negative effects of common heart medications and why heart-related issues have been increasing in recent years. For more details, links, and resources mentioned in this episode, visit our website: https://thewayfwrd.com To watch, visit YouTube: https://youtu.be/KL68_0b-nrg Connect with Dr. Stephen Hussey: Website – https://resourceyourhealth.com/ Use code WAYFORWARD for 15% off courses Related Link:  Explaining the Mechanism of Adverse Events from Covid mRNA Injections and How to Heal from Them https://resourceyourhealth.com/explaining-the-adverse-events-from-covid-mrna-injections-and-how-to-heal-from-them/ The Way Forward podcast is sponsored by: New Biology Clinic: Experience individually tailored terrain-based health services with virtual consults, practitioner livestreams, movement classes, and more. The New Biology Clinic's motivation is to make you healthy and keep you that way. Visit https://NewBiologyClinic.com and enter code TheWayForward for $50 off your activation fee. Members of The Way Forward get the full activation fee waived. Become a member of The Way Forward here: https://thewayfwrd.com/membership-sign-up/ ————————— RMDY Collective: Dedicated to making homeopathy accessible with high-quality remedies and hands-on training. Discover how this holistic approach supports natural healing and empowers you to take charge of your wellness.  Explore more at RMDY Collective at https://rmdycollective.org/?bg_ref=MKho6KZowa Enroll in RMDY Academy at https://rmdyacademy.org/?bg_ref=MKho6KZowa ————————— RA Optics: Block harmful blue light during the day and at night, optimize your biology with RA Optics. Their lenses are developed with leading experts, using advanced light-filtering technology, and their handcrafted frames offer both quality and style. Check out  Raoptics.com/twf10 and get 10% off your order. ————————— Confluence 2025: Confluence 2025 is a transformative gathering on a regenerative farm near San Antonio, TX, where community, health, and freedom meet. Join us for workshops, live music, and a chance to connect deeply with nature. Use promo code TWF10 for a 10% discount on your tickets. Join us at https://www.confluenceevent.com/