Podcast appearances and mentions of henderson hasselbalch

Chemistry 223 Video Lecture from April 16, 2025. This video covers material from Chapter 14 Part 2 including buffers, the Henderson-Hasselbalch equation, adding strong acids and strong bases to a buffer (the modified HH equation to avoid 'double ICE') and more. CH 223 website: http://mhchem.org/223 Let me know if you have any questions! Peace!

Chemistry 223 Video Lecture from April 19, 2024. This video covers material from Chapter 14 Part II of our textbook including the Henderson-Hasselbalch equation, creating a buffer, SA+SB and SB+SA titrations, WA+SB titrations (continued on Monday) and more. CH 223 website: http://mhchem.org/223 Let me know if you have any questions! Peace!

Chemistry 223 Video Lecture from April 17, 2024. This video covers material from Chapter 14 Part II of our textbook including the Common Ion Effect, buffers, "double ICE" calculations, the Henderson-Hasselbalch equation, and more. CH 223 website: http://mhchem.org/223 Let me know if you have any questions! Peace!

Chemistry 223 Video Lecture from April 21, 2023. This video covers material from Chapter 14 Part 2 including the Henderson-Hasselbalch equation, creating a buffer, an introduction to titrations, and more. CH 223 website: http://mhchem.org/223 Let me know if you have any questions! Peace!

Chemistry 223 Video Lecture from April 19, 2023. This video covers material from Chapter 14 Part 2 including calculating the pH of a buffer using the Common Ion Effect, the Henderson-Hasselbalch equation, and more. CH 223 website: http://mhchem.org/223 Let me know if you have any questions! Peace!

In episode 76 of the pharmaceutical calculations podcast, you will learn how to solve 7 key Henderson Hasselbalch equation practice problems every student should be able to solve. This episode was originally broadcast as a video on our YouTube channel: www.youtube.com/pharmaceuticalcalculationseasyAdditional Resources for Practice:Pharmaceutical Calculations: 1001 Questions with Answers: https://www.rxcalculations.com/shop/uncategorized/pharmaceutical-calculations-1001-questions-answers/NAPLEX Question Bank: https://www.rxcalculations.com/shop/uncategorized/gold-membership/Join Our Social Media Community:Website: http://www.rxcalculations.comForum: https://forum.rxcalculations.com/Facebook: https://www.facebook.com/pharmaceuticalcalculationsTwitter: https://twitter.com/RxCalculationsInstagram: https://www.instagram.com/rxcalculationsYouTube: www.youtube.com/pharmaceuticalcalculationseasyAbout RxCalculations: RxCalculations helps you master pharmaceutical calculations. We make it so you never have to worry about failing an exam or compromising patient safety because of a calculations error. RxCalculations is a leading global educational service platform focused on developing top quality pharmaceutical calculations products to help prospective pharmacists and health care professionals all over the world resolve one of the biggest challenges related to their profession.Our top quality products include affordable courses, personal consults, books, video tutorials, timed quizzes and apps designed to make you an expert in solving any pharmaceutical calculations question. We also have the largest pharmaceutical calculations online question bank which has over 1000 questions covering every important calculations topic as well as step-by-step video solutions. With all these resources at your disposal we have all you need to not only master pharmacy calculations but ace every test as well as passing your board exams.

References for Chapter 10We did not mention many references in our discussion today but our listeners may enjoy some of the references below. Effects of pH on Potassium: New Explanations for Old Observations - PMC although the focus of this article is on potassium, this elegant review by Aronson and Giebisch reviews intracellular shifts as it relates to pH and K+.Josh swooned for Figure 10-1 is this right? Which figure was it? which shows the relationship between [H+] and pH. You can find this figure in the original reference from Halperin ML and others, Figure 1 here. Factors That Control the Effect of pH on Glycolysis in Leukocytes Here's Leticia Rolon's favorite Henderson-Hasselbalch calculator website: ​​Henderson-Hasselbalch Calculator | Buffer Solutions [hint! for this site, use the bicarbonate (or “total CO2”) for A- and PCO2 for the HA] There's also a cooking tab for converting units! Fundamentals of Arterial Blood Gas Interpretation - PMC this review published posthumously from the late but beloved Jerry Yee and his group at Henry Ford Hospital, explores the details and underpinnings of our understandings of arterial blood gas interpretation (and this also addresses how our colleagues in clinical chemistry measure total CO2 - which JC referenced- but JC said “machine” and our colleagues prefer the word “instrument.”)Amy went deep on bicarbonate in respiratory acidosis. Here are her refs:Sodium bicarbonate therapy for acute respiratory acidosisSodium Bicarbonate in Respiratory AcidosisBicarbonate therapy in severe metabolic acidosisEffect of Intravenous Sodium Bicarbonate on Ventilation, Gas Exchange, and Acid-Base Balance in Patients with Chronic Pulmonary InsufficiencyBicarbonate Therapy in Severe Metabolic Acidosis | American Society of Nephrology this review article from Sabatini and Kurtzman addresses the issues regarding bicarbonate therapy including theoretical intracellular acidosis. Bicarbonate in DKA? Don't do it: Bicarbonate in diabetic ketoacidosis - a systematic review Here's a review from Bushinsky and Krieger on the effect acidosis on bone https://www.sciencedirect.com/science/article/abs/pii/S0085253822002174Here is the primary resource that Anna used in here investigation of meat replacements Nutritional Composition of Novel Plant-Based Meat Alternatives and Traditional Animal-Based MeatsWe enjoyed this paper that Dr. Rose references from the Journal of Clinical Investigation 1955 in which investigators infused HCl into nephrectomized dogs and observed changes in extracellular ions. https://www.jci.org/articles/view/103073/pdWe wondered about the amino acids/protein in some available meat alternatives they are explored in this article in the journal Amino Acids: Protein content and amino acid composition of commercially available plant-based protein isolates - PMC and you may enjoy this exploration of the nutritional value of these foods: Full article: Examination of the nutritional composition of alternative beef burgers available in the United StatesOutlineChapter 10: Acid-Base Physiology - H concentration regulated tightly - Normal H+ is 40 nm/L - This one millionth the concentration of Na and K - It needs to be this dilute because H+ fucks shit up - Especially proteins - Cool foot note H+ actually exists as H3O+ - Under normal conditions the H+ concentration varies little from normal due to three steps - Chemical buffering by extracellular and intracellular bufffers - Control of partial pressure of CO2 by alterations of alveolar ventilation - Control of plasma bicarbonate by changes in renal H+ excretion - Acid and bases - Use definition by Bronsted - Acid can donate protons - Base can accept protons - There are two classes of acids** - Carbonic acid H2CO3 - Each day 15000 mmol of CO2 are generated - CO2 not acid but combines with water to form carbonic acid H2CO3 - CO2 cleared by the lungs - Noncarbonic acid - Formed from metabolism of protein. Sulfur containing AA generate H2SO4. Only 50-100 mEq of acid produced from these sources. - Cleared by the kidneys - Law of Mass Action - Velocity of reaction proportional to the product of the concentrations of the reactants - Goes through mass action formula for water - Concludes that water has H of 155 nanoM/L, more than the 40 in plasma - Says you can do the same mass experiment for every acid in the body - Can do it also for bases but he is not going to. - Acids and Bases can be strong or weak - Strong acids completely dissociate - Weak acids not so much - H2PO4 is only 80% dissociated - Weak acids are the principle buffers in the body - Then he goes through how H is measured in the blood and it becomes clear why pH is a logical way to measure. - Then there is a lot of math - HH equation - Derives it - Then uses it to look at phos. Very interesting application - Buffers - Goes tot he phosphate well again. Amazing math describing how powerful buffers can be - Big picture the closer the pKa is to the starting pH the better buffer, i.e. it can absorb lots of OH or H without appreciably changing pH - HCO3 CO2 system - H2CO3 to H + HCO3 has a PKA of 2.72 but then lots of Math and the bicarb buffer system has a pKa of 6.1 - But the real power of the bicarb buffer is that it is not a sealed system. The ability to ventilate and keep CO2 constant increases the buffering efficiency by 11 fold and the ability to lower the CO2 below normal increases 18 fold. - Isohydric principle - There is only one hydrogen ion concentration and since that is a critical part of the buffer equation, all buffer eq are linked and you can understand all of them by understanding one of them. So we just can look at bicarb and understand the totality of acid base. - Bicarb is the most important buffer because - High concentration in plasma - Ability for CO2 to ventilate - Other buffers include - Bone - Bone is more than just inorganic reaction - Live bone releases more calcium in response to an acid load than dead bone - More effect with metabolic acidosis than respiratory acidosis - Hgb - Phosphate - Protein

Welcome to PICU Doc On Call, A Podcast Dedicated to Current and Aspiring Intensivists. I'm Pradip Kamat coming to you from Children's Healthcare of Atlanta/Emory University School of Medicine and I'm Rahul Damania from Cleveland Clinic Children's Hospital. We are two Pediatric ICU physicians passionate about all things MED-ED in the PICU. PICU Doc on Call focuses on interesting PICU cases & management in the acute care pediatric setting so let's get into our episode: In today's episode, we discuss about a 12-year-old male with lethargy after ingestion. Here's the case presented by Rahul: A 12-year-old male is found unresponsive at home. He was previously well and has no relevant past medical history. The mother states that he was recently in an argument with his sister and thought he was going into his room to “have some space.” The mother noticed the patient was in his room for about 1 hour. After coming into the room she noticed him drooling, minimally responsive, and cold to the touch. The patient was noted to be moaning in pain pointing to his abdomen and breathing fast. Dark red vomitus was surrounding the patient. The mother called 911 as she was concerned about his neurological state. With 911 on the way, the mother noticed a set of empty vitamins next to the patient. She noted that these were the iron pills the patient's sister was on for anemia. EMS arrives for acute stabilization, and the patient is brought to the ED. En route, serum glucose was normal. The patient presents to the ED with hypothermia, tachycardia, tachypnea, and hypertension. His GCS is 8, he has poor peripheral perfusion and a diffusely tender abdomen. He continues to have hematemesis and is intubated for airway protection along with declining neurological status. After resuscitation, he presents to the Pediatric ICU. Upon intubation, an arterial blood gas is drawn. His pH is 7.22/34/110/-6 — serum HCO3 is 16, and his AG is elevated. To summarize key elements from this case, this patient has: Lethargy and unresponsiveness after acute ingestion. His hematemesis is most likely related to his acute ingestion. And finally, he has an anion gap metabolic acidosis, as evidenced by his low pH and low HCO3. All of these salient factors bring up the concern for acute iron ingestion! In today's episode, we will not only go through acute management pearls for iron poisoning, but also go back to the fundamentals, and cover ACID BASE disorders. We will break this episode down into giving a broad overview of acid base, build a stepwise approach, and apply our knowledge with integrated cases. We will use a physiologic approach to cover this topic! Pradip, can you give us a quick overview of some general principles when it comes to tackling this high-yield critical care topic? Absolutely, internal acid base homeostasis is paramount for maintaining life. Moreover, we know that accurate and timely interpretation of an acid–base disorder can be lifesaving. When we conceptualize acid base today, we will focus on pH, HCO3, and CO2. As we go into each disorder keep in mind to always correlate your interpretation of blood gasses to the clinical status of the patient. Going back to basic chemistry, can you comment on the relationship between CO2 and HCO3? Yes, now this is a throwback. However, we have to review the Henderson–Hasselbalch equation. The equation has constants & logs involved, however in general this equation shows that the pH is determined by the ratio of the serum bicarbonate (HCO3) concentration and the PCO2, not by the value of either one alone. In general, an acid–base disorder is called “respiratory” when it is caused by a primary abnormality in respiratory function (i.e., a change in the PaCO2) and “metabolic” when the primary change is attributed to a variation in the bicarbonate concentration. Now that we have some fundamentals down, let's move into definitions. Can you define acidemia and alkalemia and comment on how...

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will first make you all do rollercoaster revision ride about what all we have done in recent past episodes, too quickly and then we will talk about influence of pH on passive diffusion.Then I will give you all the equations separate for weak acid and weak base, I will highlight the differences in these too! Next I will derive few basic facts and concepts related to it, after describing a little, I will open up the bundle of Implications of this equation in a point wise manner. It gonna be a little long discussion, around 10 points but truly a worthwhile pleasure to listen to, That gonna be enough tea to flood your minds cups for the day, with a promise to meet again virtually and vocally after a small time lapse, that's all folks for today!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will first make you all do rollercoaster revision ride about what all we have done in recent past episodes, too quickly and then we will talk about influence of pH on passive diffusion.Then I will give you all the equations separate for weak acid and weak base, I will highlight the differences in these too! Next I will derive few basic facts and concepts related to it, after describing a little, I will open up the bundle of Implications of this equation in a point wise manner. It gonna be a little long discussion, around 10 points but truly a worthwhile pleasure to listen to, That gonna be enough tea to flood your minds cups for the day, with a promise to meet again virtually and vocally after a small time lapse, that's all folks for today!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will first make you all do rollercoaster revision ride about what all we have done in recent past episodes, too quickly and then we will talk about influence of pH on passive diffusion.Then I will give you all the equations separate for weak acid and weak base, I will highlight the differences in these too! Next I will derive few basic facts and concepts related to it, after describing a little, I will open up the bundle of Implications of this equation in a point wise manner. It gonna be a little long discussion, around 10 points but truly a worthwhile pleasure to listen to, That gonna be enough tea to flood your minds cups for the day, with a promise to meet again virtually and vocally after a small time lapse, that's all folks for today!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Buffers are a common term in the english language, but what do they mean in Chemistry (0:39)? Episode 38 describes the chemical set up of buffers (1:31) and takes a closer look at how the buffer works on a particle level (2:03). To calculate the pH of a buffer the episode describes the Henderson-Hasselbalch equation (3:04). Using the theme of equal concentration of conjugate acid/base pair, two approaches to prepare a buffer solution are described (5:39) and the concept of buffer capacity is being discussed (6:36).Question: How does a smaller concentration of conjugate base than weak acid affect the pH of a buffer?Thank you for listening to The APsolute RecAP: Chemistry Edition!(AP is a registered trademark of the College Board and is not affiliated with The APsolute RecAP. Copyright 2021 - The APsolute RecAP, LLC. All rights reserved.)Website:www.theapsoluterecap.comEMAIL:TheAPsoluteRecAP@gmail.comFollow Us:INSTAGRAMTWITTERFACEBOOKYOUTUBE

This episode discusses about pH and its influence on amino acids, as well as the Henderson-Hasselbalch equation to quantify pH effects.

A screencast from Chapter 14 in CH 223 which introduces the Henderson-Hasselbalch equation, which is arguably the most important equation of CH 223. https://mhchem.org/223/classroom/zAudio/Ch18IcBuffersHHEq.mp4

Chemistry 223 Video Lecture from April 17, 2019 covering Chapter 14 Part II in our textbook including the common ion effect, buffers, the Henderson-Hasselbalch equation, and more.

Calculate the pH of an acidic acid buffer using Henderson-Hasselbalch equation.

Carboxylic acid nomenclature; structure and properties; acidity; the Henderson-Hasselbalch equation; substituent effects on acidity; preparation; spectroscopy