Podcasts about effects

Send us a textPharmacology & neurobiology of psychedelics & MDMA, focusing on isomers, sex-specific effects, and mechanisms in animal models. Not medical advice.TOPICS DISCUSSED:Biased agonism: Different drugs activate the same receptor (e.g., 5-HT2A) but trigger varied intracellular pathways, explaining why LSD is psychedelic while similar lisuride is not.Enantiomers & isomers: Mirror-image versions of drugs like MDMA (S and R forms) and LSD (four isomers) often produce distinct effects; only one LSD isomer is psychedelic, for example.MDMA isomer effects: S-MDMA induces stronger head twitches (psychedelic proxy) via serotonin release, and increases dendritic spines in male mice but not females; R-MDMA has somewhat different effects.Sex-specific drug responses: In mice, females show stronger psychedelic effects (head twitches) from psilocybin and DOI at the same dose, but males exhibit greater post-acute benefits like reduced opioid withdrawal.Psilocybin in opioid addiction models: A single dose reduces place preference for oxycodone and withdrawal symptoms in male mice more than females, with opposite spine density effects in reward-related brain areas.Mechanisms beyond 5-HT2A: Psychedelics involve other receptors like metabotropic glutamate receptors, forming dimers with 5-HT2A to enable dual signaling pathways; effects in subcortical regions like nucleus accumbens are 5-HT2A-independent.Clinical implications: Street MDMA may vary in S/R ratios, affecting experiences; clinical trials often use racemic mixtures without weight-adjusted dosing, potentially missing sex differences.ABOUT THE GUEST: Javier Gonzalez-Maeso, PhD is a professor of pharmacology and toxicology at Virginia Commonwealth University, with a PhD in medicine from Spain focused on G-protein coupled receptors and human brain studies in depression and addiction.RELATED EPISODE:M&M 230 | Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael WheelerSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Join QEEG legend Jay Gunkelman (500,000+ scans) and Dr. Mari Swingle (i-Minds author) with host Pete Jansons for a deep morning dive into EEG patterns, drugs, and brain dynamics.✅ Topic 1: Delta Waves – What They Really MeanDiffuse/global delta: lack of white-matter input, sheet dipoles, parenchymal layersInfra-slow oscillations (less 1 Hz): oxygenation cycles (Yuri Crop), 6 breaths/min resonanceClinical implications: encephalopathy, developmental vs acquired✅ Topic 2: Alpha Blocking & ReactivityBurger effect: eyes-open alpha attenuation ≥50% at O1/O2/PzNon-responsive alpha phenotype = severe disconnect from external worldLow-voltage fast EEG: over-arousal, GABA can slow & reveal alpha✅ Topic 3: Psychedelics & Hallucinogens on EEGDramatic connectivity changes vs medicationsSalvia: gigantic 6–10 s slow waves (600–1000 µV), dissociationRisk: epileptiform activity + DMT/MDMA/psilocybin/ketamine = major contraindicationLow-dose LSD: possible anticonvulsant effect (historical Larry Rouse study)✅ Topic 4: Cannabis (Weed) – Acute vs Chronic EEG EffectsAcute: slows background alpha → helps sleep onsetChronic (Struve work): increases frontal alpha coherence → risk of apathy, depression, affective dysregulation (especially if baseline alpha already high/fast)✅ Bonus NuggetsHRV–EEG overlap: cardio-ballistic artifact, pulse artifact, vagal slowingStatic electricity on hair: minimal issue with proper groundingCarl Pribram memory: holographic storage, traveling waves (John Hughes), personal anecdotesFuture EEG trends: less alcohol → more THC? Shift toward frontal coherence issues

Politicians are touting “affordability” to describe the current regime of rising prices. However, most lawmakers who claim they are trying to make things more affordable demand policies that make things more costly.Original article: https://mises.org/mises-wire/why-affordability-wrong-term-describe-effects-inflation

The powerful, wealthy figures in the newly released Epstein files. Then, an update on when the partial government shutdown is expected to end, and whether it'll lead to any real change to immigration enforcement. Plus, new reporting on the half-a-billion-dollar deal between UAE royalty and the Trump family crypto business. Luke Broadwater, Daniella Diaz, Susan Glasser, Julie K. Brown, Sam Kessler, and Ron Insana join The 11th Hour this Monday night. To listen to this show and other MS podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Modern life imposes an invisible "stress tax" on your nervous system through complex and chaotic electromagnetic fields that disrupt cellular timing and mitochondrial function. Aires CEO Josh Bruni joins me to explain why structuring these chaotic signals is the essential next step in environmental wellness. By mitigating this "invisible noise," you allow your body to stop fighting its environment and start functioning as it was meant to.   CLICK HERE TO BECOME GARYS VIP!: https://bit.ly/4ai0Xwg Connect with Josh Bruni Website: https://bit.ly/4a3Duze  YouTube: https://bit.ly/4a3Dz60  Instagram: https://bit.ly/4a3MyV2  Facebook: https://bit.ly/3OakMyx  X: https://bit.ly/4bpkm0Z  LinkedIn: https://bit.ly/3ZFora8  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij  AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD  AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze    BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa  BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV  CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC  COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp  GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk  GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9  GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC  H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg  HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S  PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn  RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0  SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V  WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW  Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show 04:15 EMFs: Definition, Effects, and How to Mitigate Them 22:31 Blocking vs. Mitigating EMFs 29:42 EMF Mitigation Technology 35:18 Environment and Stress's Impact on Our Body 40:41 40 STUDIES on EMFs: https://bit.ly/4sY3810  44:09 Restructuring EMF to Neutralise Physiological Impact 45:39 How Bad is the Complexity of 5G for People? 51:55 Where to Start in Mitigating EMF Exposure 1:00:53 Modern Vehicles' Designs Risks 1:04:16 Hypersensitivity with EMFs 1:08:59 Mitigating EMF Exposure in Your Own Home 1:14:28 Are Women More Sensitive to EMFs than Men? 1:19:54 Equating the Frequency of Connected Devices 1:28:49 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Got thyroid questions? I might just have the answers for you in this episode.In the second part of "Your Thyroid Questions Answered", we'll dive into topics like reducing thyroid nodules, understanding your TSH numbers, and managing autoimmune thyroid conditions like Hashimoto's. From managing inflammation to figuring out if you can ever get off thyroid meds, I'll give you real, actionable answers. I'll also share the important role of lifestyle changes and supplements in managing thyroid health. If you've been struggling to make sense of your thyroid health or just want to understand your body better, this episode is for you.Tune in to get the insights you need and take charge of your thyroid health.Episode Timeline: 00:04 – Introduction to Thyroid FAQs02:15 – Reducing Thyroid Nodules06:00 – Supplements for Thyroid Eye Disease10:30 – Regrowing a Shrinking Thyroid12:45 – Radio Frequency Ablation for Nodules15:00 – Effects of L-Carnitine on Thyroid19:00 – Vaccines and Thyroid Health22:30 – Hot Nodules and Flare-ups24:00 – Managing Stress for Thyroid Health27:00 – Hypothyroidism with Elevated T430:30 – Hyperthyroidism & Autoimmune Connections32:00 – Managing Hyperthyroidism & Pregnancy37:30 – Iron Deficiency and Thyroid Health40:00 – Importance of Gut Health41:00 – Thyroid Medication and Resistance45:00 – Conclusion and Next StepsIf you want to subscribe to my free Healing Graves' Naturally newsletter visithttps://savemythyroid.com/GravesNewsletter Free resources for your thyroid healthGet your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.comHigh-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' s Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid?Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles Watch Dr. Eric's YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos Join Dr. Eric's Graves' disease and Hashimoto's group: https://www.facebook.com/groups/saveyourthyroid Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308 Read all of Dr. Eric's published books: http://savemythyroid.com/thyroidbooks Work with Dr. Eric: https://savemythyroid.com/work-with-dr-eric/

On Monday's Drivetime with DeRusha.... 3pm Hour: Jason starts the show talking about the potential long-term harm to Minnesota businesses by the ICE surge and all that's stemmed from it. Are we concerned enough? Then, should a football GM get to take two weeks of paternity leave? 4pm Hour: Jason's joined by Kate Raddatz for The Radd Report - are you in the thick of Summer Camp registration hell? Then, why some of you are making the ICE situation even worse. 5pm Hour: On the DeRush-Hour, Jason goes "In Depth" with Chris Magan from the Star Tribune who reports on an Ecuadorian family seeking refugee status, who decided to self-deport. Then Dave Schwarts joins the show talking Vikings, Twins, Wolves and Wild!

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Diane Hennacy, M.D. is a Johns Hopkins-trained neuropsychiatrist and neuroscientist, former Harvard faculty member, and an award-winning author and clinician. She began studying autism in 1987, when she spent six months with Sir Michael Rutter at the Institute for Psychiatry in London. Her decades long research focused on investigating reports of telepathy and precognition in autistic children was the inspiration for The Telepathy Tapes. SPONSORS https://mizzenandmain.com - Use code DANNY20 for 20% off your first order. https://prizepicks.onelink.me/LME0/DANNY - Use code DANNY & get $50 in lineups when you play your first $5 lineup! https://amentara.com/go/DJ - Use code DJ22 for 22% off your first order. https://shopmando.com - Use code DANNY for 20% off + free shipping. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off EPISODE LINKS https://drdianehennacy.com https://hennacyinstitute.org FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTILNE 00:00 - How a Johns Hopkins trained psychiatrist got into ESP 04:46 - Savant Syndrome 06:48 - Why psychiatry disagrees with parapsychology 07:20 - Working down the hall from John Mack 11:28 - Why Diane wanted to be a neurosurgeon 16:34 - Where memory is stored in the brain 18:42 - Hippocampus' role in memory & ESP 25:51 - How oxygen deprivation destroys memory 30:49 - Harmful brain effects of breath-holding 32:14 - Effects of ketogenic state on the brain 35:25 - The autism & telepathy connection 39:44 - Savant Syndrome in blind & autistic individuals 45:51 - Neuroscience is a flawed model 51:06 - The analytical couch & the root of psychiatry 57:45 - How to prove or disprove ESP phenomena 01:01:57 - 97% accuracy telepathy test 01:11:21 - Possible materialist explanation for autistic ESP 01:16:25 - Why autistic individuals are more likely to experience ESP 01:25:25 - The problems with memory 01:26:50 - People who can't forget anything (hyperthymesia) 01:30:41 - White matter in the brain 01:34:48 - Microtubules & consciousness 01:40:53 - How to advance microtubule research 01:43:00 - Ultrasound as Alzheimer's therapy 01:45:30 - Applications of infrared light therapy 01:54:12 - The body's internal "fiber optic" system 01:58:21 - Human's natural telepathic abilities have atrophied over time 02:01:17 - Schools are failing our youth 02:05:13 - Ancient humans' telepathic abilities 02:09:45 - How the bible warns against the written word 02:15:09 - Autistic telepathic kids who mention bible characters 02:19:43 - The sixth sense humans have buried inside them 02:24:02 - The hidden superpowers of the nose 02:28:36 - How your nose can smell true love 02:32:23 - The new split in human evolution 02:35:32 - Proof of technologically advanced ancient humans 02:40:59 - The filter hypothesis 02:48:10 - Disproving the materialist model 02:51:38 - Non-autistic people with ESP 02:54:20 - Autistic people who see dead people Learn more about your ad choices. Visit podcastchoices.com/adchoices

Most of us are completely oblivious to the cognitive biases that dictate how we live our lives.  Today, with Tom Bowden-Green and Luan Wise, we cover seven cognitive biases that all of us fall for.  ---  Tom and Luan's book: https://amzn.to/49aZnh3 Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults See Agent Spark in action at ⁠gwi.com/spark⁠ Join 10,428 readers of my newsletter: https://www.nudgepodcast.com/mailing-list  Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/  ---  Today's sources:  Chambers, J. R. (2008). Explaining false uniqueness: Why we are both better and worse than others. Social and Personality Psychology Compass, 2(2), 878–894. Dunning, D. (2011). The Dunning–Kruger effect: On being ignorant of one's own ignorance. In Advances in experimental social psychology (Vol. 44, pp. 247–296). Academic Press. Einhorn, H. J., & Hogarth, R. M. (1978). Confidence in judgment: Persistence of the illusion of validity. Psychological Review, 85(5), 395–416. Helmreich, R., Aronson, E., & LeFan, J. (1970). To err is humanizing sometimes: Effects of self-esteem, competence, and a pratfall on interpersonal attraction. Journal of Personality and Social Psychology, 16(2), 259–264. Koskie, M. M., & Locander, W. B. (2023). Cool brands and hot attachments: Their effect on consumers' willingness to pay more. European Journal of Marketing, 57(4), 905–929. Pronin, E., Lin, D. Y., & Ross, L. (2002). The bias blind spot: Perceptions of bias in self versus others. Personality and Social Psychology Bulletin, 28(3), 369–381. Van Hoorens, V. (1993). Self-enhancement and superiority biases in social comparison. European Review of Social Psychology, 4, 113–139. White, G. L., Fishbein, M., & Rutstein, R. C. (1981). Passionate love and the misattribution of arousal. Journal of Personality and Social Psychology, 41(1), 56–62.

In this episode, I break down a live webinar audit where I had to step in and fix a “buy-live” bonus that looked smart on the surface but was quietly eroding trust underneath. I walk through how I evaluate urgency beyond just short-term conversions, why arbitrary timers create second-order damage, and how to redesign live bonuses so they reward presence without punishing replay buyers. If you've ever added a bonus to “increase urgency” and wondered why your replays underperform or your offer starts to feel like “just a course,” this episode will completely change how you think about live selling, buyer psychology, and ethical urgency.

It's gator time, folks! It seems like we should've already covered this topic, but, nope, this is our first ever episode on the American Alligator (Alligator mississippiensis), and we've got two ringers to help: Daniel returns (our Field Guide host who moved to Florida last year) and he's joined by his mentor in all things swamp-related, Chip Campbell. Chip spent twenty years running Okefenokee Adventures, leading interpretive tours in the Okefenokee National Wildlife Refuge, and his knowledge of alligator natural history and ecology runs deep.Thanks to our Patrons, this episode is also an on-the-road joint. The guys are deep in the Florida Everglades on a multi-day paddling trip, and they take a break at camp to talk with Chip about all things alligator — with a special focus on separating gator myths from reality.And, unfortunately for those of you crushing on Steve, this one's 100% Steve-free.This episode was recorded on Dec. 31, 2025 at Watson's Place campsite in Everglades National Park.Episode Notes and LinksAlligators, metabolism, and the “dog comparison”During the episode, Chip mentioned a study suggesting that several alligators could be maintained on roughly the same caloric intake as a single dog. We were not able to locate a study that makes that specific numerical comparison. However, the underlying idea is strongly supported by research on alligator physiology: American alligators have extremely low metabolic rates compared to warm-blooded mammals because they are ectothermic and do not spend energy maintaining body temperature. Classic physiological work shows that adult alligators can have daily energy expenditures that are only a small fraction of those of similarly sized mammals, making informal comparisons like this directionally accurate even if the exact ratio is anecdotal rather than experimental. Source: Coulson, R. A. (1989). Biochemistry and physiology of alligator metabolism in vivo. Integrative and Comparative Biology, 29(3), 921–934. https://doi.org/10.1093/icb/29.3.921Freshwater “sipping” — the study behind the observation The behavior Chip describes is documented in a study by Nifong and Lowers, which examined how coastal alligators use estuarine habitats. The authors note that after heavy rainfall, a thin layer of freshwater can temporarily sit on top of saltier water, and alligators will take advantage of this by drinking from the surface. This helps them manage hydration and salt balance in brackish environments, despite lacking the salt-excreting glands found in crocodiles. Source: Nifong, J. C., & Lowers, R. H. (2017). Reciprocal intraguild predation between Alligator mississippiensis and elasmobranchs in the southeastern United States. Southeastern Naturalist, 16(3), 383–396.Alligator growth vs. ageChip addressed the myth that alligators continue to grow throughout their life. Echoing what he reported, research on American alligators shows that although hatchlings and juveniles grow rapidly, their rate of growth slows substantially as they get older, and studies indicate they reach near-maximum body size well before the end of their lives. Long-term data suggest many alligators stop adding significant length by roughly 25–35 years of age, and more recent work has revised the classic idea of indefinite growth toward a pattern of determinate growth with a growth plateau in adulthood. Human harvest of alligators in LouisianaAs Chip said, Louisiana supports the largest wild harvest program for the American alligator in the United States, with more than 2,000 licensed hunters routinely harvesting an estimated 30,000–35,000 wild alligators annually under a regulated tagging system. In contrast, other states such as Florida have had regulated harvest programs with substantially lower annual take.” Sources: Joanen et al. (2021), Evaluation of Effects of Harvest on Alligator Populations in Louisiana, Journal of Wildlife Management; Louisiana Department of Wildlife and Fisheries Alligator Annual Report (2019–2020); Hines (SEAFWA) status report on Florida alligators.Fatal Alligator AttacksIn this episode, Chip discusses the history of fatal alligator-human conflicts, highlighting the 1973 Sharon Holmes incident as the first "fully confirmed" fatal attack in modern records. While the Holmes incident is often cited as the definitive first case, there was an earlier death that some consider to be the first modern fatality. Historical records show why Chip's reference to the Holmes case being the first “fully confirmed” case is accurate:Sharon Holmes (1973): On August 16, 1973, 16-year-old Sharon Holmes was killed while swimming at Oscar Scherer State Park. This is widely cited as the first fully confirmed fatality because of the absolute nature of the evidence: the attack was witnessed by bystanders, and a subsequent necropsy of the 11-foot 3-inch alligator found conclusive physical remains. This event marked a turning point in how state agencies, like the Florida Fish and Wildlife Conservation Commission (FWC), tracked and verified alligator-related deaths.Allen Rice (1957): While most official FWC lists of fatal attacks begin in 1973, the 1957 death of 9-year-old Allen Rice in Eau Gallie is often mentioned as an earlier case. However, it is technically categorized as presumed. Rice went missing while fishing, and though his body was recovered with injuries consistent with an alligator and a large gator was seen nearby, there were no direct witnesses to the strike. Sponsors and Ways to Support UsGumleaf Boots, USA (free shipping for patrons)Thank you to Always Wandering Art (Website and Etsy Shop) for providing the artwork for this and many of our episodes.Support us on Patreon.Works CitedCoulson, R. A. (1989). Biochemistry and physiology of alligator metabolism in vivo. Integrative and Comparative Biology, 29(3), 921–934. https://doi.org/10.1093/icb/29.3.921James C. Nifong & Russell H. Lowers (2017). Reciprocal Intraguild Predation between American Alligator (Alligator mississippiensis) and Elasmobranchii in the Southeastern United States. Southeastern Naturalist 16(3): 383–396.Joanen et al. (2021), Evaluation of Effects of Harvest on Alligator Populations in Louisiana, Journal of Wildlife Management; Louisiana Department of Wildlife and Fisheries Alligator Annual Report (2019–2020); Hines (SEAFWA) status report on Florida alligators.McIlhenny, E.A. (1935) The Alligator's Life History. Boston: The Christopher Publishing House.Photo CreditThanks again Always Wandering Art (Website and Etsy Shop) for the amazing gator painting!

In this episode, I interview Patrick from Typ3cannabis, who dives into the art and science of breeding plants for distinct flavors and effects. Our conversation covers how genetics, selection, and intentional breeding decisions shape aroma profiles, potency, and the overall experience. We also discuss the challenges breeders face and the techniques used to bring truly unique traits to life.Support the show

I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn Editor in Chief of Kidney International Case ReportsAnna Gaddy (@AnnaGaddy) Winner of NephJC Rookie of the Year 2020Nayan Arora (@CaptainChloride.bsky.social)AC (@medpeedskidneys.bsky.social)Vipin Verghese (@vipvargh.bsky.social) co-winner of NephJC Engaged Scientist of the Year in 2021Brian Rifkin (@brianrifkin.bsky.social) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021Cristina Popa (@NephroSeeker) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023Editing and Show Notes byAnna Gaddy and Joel TopfThe Kidney Connection written and performed by Tim YauShow NotesTop Stories in Nephrology 2025 (NephJC)First Top sories in Nephrology 2010! (Renal Fellow Network)Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC)1. IgA NephropathyVISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM)ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM)Aliza M. Thompson, MD, MS (ASN) 2. Lupus NephritisREGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM)3. Nobel prize winner and peripheral immune tolerance4. Xenotransplantation5. GLP1ra RevolutionRemodel REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Kidney International)SURPASS-CVOT Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (Kidney Week abstract in JASN)Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford (KFF survey)6. GDMT implementation in CKD: lessons learnt from CONFIDENCE and MIRO-CKDConfidence Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (NEJM)MIRO-CKD Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial (The Lancet)7. Flozin Meta analysisSMART-C. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria. A Meta-Analysis (JAMA)SMART-C. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria. A Meta-Analysis (JAMA)8. Paradigm Shift: Aiming for CKD Remission9. Fish Oil and DialysisPISCES Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)10. Decline in Dialysis Patients in the United StatesUSRD 2025 Annual Data Report (USRDS)Tubular SecretionSwapnil Hiremath Alien Earth on FX Hulu (Wikipedia)AC A Christmas Carol by Charles Dickens (Wikipedia) and The Muppet Christmas Carol (Wikipedia)Anna Monty Don (Wikipedia)Nayan Back Street Boys at The Sphere (Wikipedia)Brian Marty Supreme (Wikipedia)Cristina The Yellow Tie (Wikipedia)Vipin Stranger Things, good for a four year old? (Wikipedia)Joel Crash Course: The Universe with Katie Mack and John Green (Apple PodCasts)

Please Join us in supporting one of Manuel's students whose world was turned upside down this week when her father was detained by ICE. Click here for the GoFundMe. This Week: While the harm has, to a significant extent, already been done, there was an important legal victory in the fight against the white supremacist, fascist effort to destroy public education. A lawsuit brought by the AFT and others last summer resulted in a federal judge declaring the administration's attempt to outlaw “illegal discrimination” against white people, and requiring that districts and universities certify they don't practice DEI was enacted without following proper procedures. Just this month the administration declared they are dropping their appeal. This is one of numerous legal defeats the administration has suffered, however their fascist overreach continues, raising continued constitutional crises, and reinforcing the chilling effect of their racist agenda. Also, new research from scholars in New York state shows the lasting harm that ICE and DHS terrorism causes children who experience it themselves, or with a family member. Anxiety, depression, absenteeism, and chronic stress are likely just the tip of the iceberg. Thankfully a growing number of ed advocacy groups are speaking out against ICE terrorism and declaring it an existential threat to the safety of America's children and school communities. Manuel and Jeff discuss. MAXIMUM WOKENESS ALERT -- get your All of the Above swag, including your own “Teach the Truth” shirt! In this moment of relentless attacks on teaching truth in the classroom, we got you covered. https://all-of-the-above-store.creator-spring.com Watch, listen and subscribe to make sure you don't miss our latest content!Listen on Apple Podcast and Spotify Website: https://AOTAshow.comFollow us: LinkedIn, Facebook, Twitter

OA1231 - The DHS funding battle is important, but really can't accomplish what you might hope it can. When it comes to the Fed, ALL OF A SUDDEN the court cares about the real world effects of their decisions. And a figure skating related footnote!  

Send us a textDo Heterogeneous Treatment Effects Exist?For the last 50 years, we've designed cars to be safe...For the 50th-percentile male.Well, that's actually not 100% correct.According to Stanford's report, we introduced "female" crash test dummies in the 1960s, but...They were just scaled-down versions of male dummies and...Represented the 5th percentile of females in terms of body size and mass (aka the smallest 5% of women in the general population).These dummies also did not take into account female-typical injury tolerance, biomechanics, spinal alignment, and more.But...Does it matter for actual safety?In the episode, we cover:- Do heterogeneous treatment effects (different effects in different contexts) exist?- If so, can we actually detect them?- Is it more ethical to look for heterogeneous treatment effects or rather look at global averages?Video version available on the Youtube: https://youtu.be/V801RQTBpp4Recorded on Nov 12, 2025 in Malaga, Spain.------------------------------------------------------------------------------------------------------About RichardProfessor Richard Hahn, PhD, is a professor of statistics at Arizona State University (ASU). He develops novel statistical methods for analyzing data arising from the social sciences, including psychology, economics, education, and business. His current focus revolves around causal inference using regression tree models, as well as foundational issues in Bayesian statistics.Connect with Richard:- Richard on LinkedIn: https://www.linkedin.com/in/richard-hahn-a1096050/About StephenStephen Senn, PhD, is a statistician and consultant who specializes in drug development clinical trials. He is a former Group Head at Ciba-Geigy and has taught at the University of Glasgow and University College London (UCL). He is the author of "Statistical Issues in Drug Development," "Crossover Trials in Clinical Research," and "Dicing with Death."Connect with Stephen:- Stephen on LinkedIn: Support the showCausal Bandits PodcastCausal AI || Causal Machine Learning || Causal Inference & DiscoveryWeb: https://causalbanditspodcast.comConnect on LinkedIn: https://www.linkedin.com/in/aleksandermolak/Join Causal Python Weekly: https://causalpython.io The Causal Book: https://amzn.to/3QhsRz4

Bobby talks about the effects the ice storm has had on his house and his friend’s places. Amy talked about the struggles staying with her pets at her friend’s house. Lunchbox talked about letting another family stay with him. Amy shares how she is studying things about her brain and remembers the time she bought something illegal on a street corner. Amy explained why writing a letter to your future self can help you with anxiety. Bobby shared his idea for a book to be released after he dies.See omnystudio.com/listener for privacy information.

Recent randomized controlled trials have shown that routine perioperative palliative care does not improve outcomes for patients undergoing curative-intent cancer surgery. No, that wasn't a typo. Regardless of how the data were analyzed, the findings remained consistent: perioperative palliative care DID NOT improve outcomes in the only two randomized controlled trials conducted in this area—the SCOPE and PERIOP-PC trials. Null trials like these often receive less attention in academic and clinical settings, but they can be profoundly practice-changing. Consider the Shannon Carson study on palliative care for chronically critically ill patients. While some have argued it "wasn't a palliative care study," I've always regarded it as one of the most significant studies for understanding not what works—but what doesn't—for palliative care in specific patient populations. The same holds true for the SCOPE and PERIOP-PC trials. Both were null, but their findings are deeply relevant to clinical practice. That's why we invited the lead authors, Rebecca Aslakson (PERIOP-PC) and Myrick "Ricky" Shinall (SCOPE), to share insights into what they did in their studies and why they think they got the results that they did. One key takeaway for me from this discussion was the idea that patients undergoing curative-intent surgery might simply be too early in their cancer trajectory to derive meaningful benefits from palliative care, and maybe the focus should be more on geriatrics. I especially appreciated the closing discussion about the future of research in this area: if routine perioperative palliative care doesn't improve outcomes, what should the next generation of studies focus on? Eric Widera   Studies we talk about during the podcast Aslakson et al. Effect of Perioperative Palliative Care on Health-Related Quality of Life Among Patients Undergoing Surgery for Cancer: A Randomized Clinical Trial. JAMA Netw Open. 2023 Shinall et al. Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: A Randomized Clinical Trial. JAMA Surg. 2023 Carson et al. Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial. JAMA. 2016 Holdsworth et al. Patient Experiences of Specialty Palliative Care in the Perioperative Period for Cancer Surgery. JPSM. 2024 Williams et al. Patient Perceptions of Specialist Palliative Care Intervention in Surgical Oncology Care. Am J Hosp Palliat Care. 2025  Yefimova et al. Palliative Care and End-of-Life Outcomes Following High-risk Surgery. JAMA Surg. 2020   

In this episode of the Epigenetics Podcast, we talked with Peggy Farnham from the Keck School of Medicine at USC about her work on establishing the ChIP Method in mammalian cells. In this episode, we dive into the relationship between transcription factors, chromatin dynamics, and gene expression with Professor Peggy Farnham from the Keck School of Medicine at USC. Professor Farnham shares her profound insights into how her groundbreaking research has reshaped our understanding of gene regulation and its implications in cancer. We explore how she has been a pioneer in mapping the genome-wide landscape of regulatory proteins, illuminating the molecular logic behind transcriptional control and its disruption in cancer biology. The interview starts with her instrumental role in adapting chromatin immunoprecipitation (ChIP) technology from yeast to human cells. Professor Farnham reflects on the technical challenges she faced during this transition, such as the quest for visibility of signals in mammalian systems. Her ability to innovate and troubleshoot challenges led to significant advancements in techniques that allow for the rapid identification of transcription factor binding sites, fundamentally changing the landscape of epigenetic research. As the discussion progresses, we learn about Professor Farnham's active involvement in the ENCODE project, where she contributed to high-resolution mapping of transcription factors and regulatory elements in human cells. She articulates her appreciation for collaborative efforts in science, highlighting how working within a consortium harnesses the collective expertise of diverse research groups. This collaboration not only bolstered the credibility of the data produced but also propelled the field forward in understanding the complexity of gene regulation. Through her participation in various projects, such as the Psyc-ENCODE consortium and the Roadmap Epigenome Mapping Consortium, Professor Farnham shares insights into her investigation of epigenetic variations, particularly in relation to complex disorders like schizophrenia. Her findings underscore the nuances of enhancer variability among individuals and the implications for understanding disease mechanisms, thereby advancing our knowledge of genetic regulation and its contributions to diverse biological outcomes. Moreover, the episode highlights Professor Farnham's reflective understanding of emerging technologies in the field. She discusses the evolution of methods that allow researchers to investigate gene regulation at single-cell resolution, recognizing the significant implications these innovations have for our comprehension of cellular differentiation and the transcriptional landscape. References Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Molecular and Cellular Biology. 2001 Oct;21(20):6820-6832. DOI: 10.1128/mcb.21.20.6820-6832.2001. PMID: 11564866; PMCID: PMC99859. Wells J, Farnham PJ. Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (San Diego, Calif.). 2002 Jan;26(1):48-56. DOI: 10.1016/s1046-2023(02)00007-5. PMID: 12054904. Rhie SK, Schreiner S, Witt H, et al. Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Science Advances. 2018 Dec;4(12):eaav8550. DOI: 10.1126/sciadv.aav8550. PMID: 30555922; PMCID: PMC6292713. Tak YG, Hung Y, Yao L, et al. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Research. 2016 May;44(9):4123-4133. DOI: 10.1093/nar/gkv1530. PMID: 26743005; PMCID: PMC4872074. Related Episodes The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) The Future of Protein–DNA Mapping (Mitch Guttman) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this podcast episode, the speaker shares his personal journey of quitting THC, explaining his reasons, the gradual process over several years, and the impacts on his life. He recounts his history with THC, from early recreational use to daily dependence for sleep aid during medical school and residency. The speaker emphasizes that he does not oppose cannabis, recognizing its medicinal value, but wanted to overcome his dependency. He details his method of reducing THC use through vaping and CBD alternatives, ultimately leading to his last use in January 2025. Alongside his personal story, he discusses the benefits and potential negative impacts of THC and other cannabinoids, offering insights into who might consider quitting and why.   Cannabis, THC & Quitting Cannabis (Marijuana) — NIDA overview: https://nida.nih.gov/research-topics/cannabis-marijuana Cannabis Use Disorder — NCBI Bookshelf (StatPearls): https://www.ncbi.nlm.nih.gov/books/NBK538131/   Sleep, REM & Withdrawal Cannabis and sleep architecture — systematic review (PubMed): https://pubmed.ncbi.nlm.nih.gov/40967124/ Effects of cannabinoids on sleep — review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC8116407/   Non-Intoxicating Cannabinoids Mentioned CBD + anxiety — systematic review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11595441/   CBG — acute effects + cognition (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11246434/ THCV — overview/commentary (PubMed): https://pubmed.ncbi.nlm.nih.gov/33526143/ CBC — therapeutic potential review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11493452/   Potency: Concentrates Marijuana Concentrates — NIDA DrugFacts PDF: https://nida.nih.gov/sites/default/files/df-marijuana-concentrates.pdf   Supplements Mentioned Omega-3 Fatty Acids — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/ Vitamin D — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/VitaminD-Consumer/   Show Notes 00:00 Introduction: Why I Quit THC 02:18 My History with THC 06:10 Transition to Medical Use 13:53 The Quitting Process 20:11 Benefits and Challenges of Quitting 25:07 Thoughts on THC and Other Cannabinoids 33:25 Conclusion and Final Thoughts   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

Finally, after nearly 10 years, it's the changing criterion design's time to shine! While often seen as the little brother to our more robust experimental designs, this week we discuss when the changing criterion could be your design of choice in research and practice and look at some of the more convincing cases of how the little step-wise graph that nobody liked should really be a key player in your visual display toolbox. This episode is available for 1.0 LEARNING CEU. Articles discussed this episode: Klein, L.A., Houlihan, D., Vincent, J.L., & Panahon, C.J. (2017). Best practices in utilizing the changing criterion design. Behavior Analysis in Practice, 10, 52-61. doi: 10.1007/s40617-014-0036-x De Luca, R.V. & Holborn, S.W. (1992). Effects of a variable-ratio reinforcement schedule with changing criteria on exercise in obese and nonobese boys. Journal of Applied Behavior Analysis, 25, 671-679. doi: 10.1901/jaba.1992.25-671 Brady, M.P., Kearney, K.B., Downey, A., Torres, A., & McDougall, D. (2022). Using mnemonics, remote coaching, and the range-bound changing criterion design to teach college students with IDD to make employment decisions. Education and Training in Autism and Developmental Disabilities, 57, 303-319. doi: 10.1177/215416472205700 If you're interested in ordering CEs for listening to this episode, click here to go to the store page. You'll need to enter your name, BCBA #, and the two episode secret code words to complete the purchase. Email us at abainsidetrack@gmail.com for further assistance.

Learn More and Earn CEUs with The Movement System: https://www.themovementsystem.com         References: Oranchuk, D., Storey, A., Nelson, A. and Cronin, J. Scientific basis for eccentric quasi-isometric resistance training: a narrative review. J Strength Cond Res. 2019; 33 (10): 2846-2859. Lum, Danny et al. "Comparing the Effects of Long-Term vs. Periodic Inclusion of Isometric Strength Training on Strength and Dynamic Performances." Journal of strength and conditioning research vol. 37,2 (2023): 305-314. doi:10.1519/JSC.0000000000004276 Schaefer, L., Hoff, M. and Bittmann, F. Measuring the adaptive force. Eur J Transl Myol. 2015; 27 (3): 152-159. Lum D, Haff GG, Barbosa TM. The relationship between isometric force-time characteristics and dynamic performance: a systematic review. Sports. 2020;8:63. Lum, D., Barbosa, T.M., Joseph, R. et al. Effects of Two Isometric Strength Training Methods on Jump and Sprint Performances: A Randomized Controlled Trial. J. of SCI. IN SPORT AND EXERCISE 3, 115–124 (2021). https://doi.org/10.1007/s42978-020-00095-w Lum D, Joseph R. Relationship between isometric force-time characteristics and dynamic performance pre- and post-training. J Sports Med Phys Fit. 2020;60(4):520–6.

Mark Manson is a bestselling author, blogger, and cultural commentator known for his honest, no-nonsense take on personal growth. He first gained global recognition with Models, a practical guide to dating and authenticity, followed by the international bestseller The Subtle Art of Not Giving a F*ck. His work challenges traditional self-help by emphasizing values, responsibility, and psychological realism. Mark also hosts the podcast SOLVED, where he explores life's hardest questions through science, philosophy, and candid conversation.In our conversation we discuss:(0:34) – Reinventing identity across career stages(4:31) – Advice for releasing outdated identities(8:29) – Letting go of former selves(10:55) – Effects of quitting alcohol(16:59) – Handling social stigma when not drinking(19:08) – Developing a healthy relationship with boredom(25:59) – Subtraction versus addition in personal growth(28:33) – Balancing self-acceptance and self-improvement(30:55) – Motivation without tying worth to success(33:44) – What deserves a scarcity mindset(36:49) – When suffering gives life meaning(41:40) – Finding a meaningful purpose to pursue(44:24) – Values grounded in personal control(47:13) – Identity tied to work in future societies(52:02) – How status changes when wealth declines(53:48) – Self-help as modern secular religion(59:32) – Will religion make a comeback(1:02:05) – Law of “fuck yes or no” explained(1:04:04) – Key questions to evaluate relationships(1:06:08) – Identifying non-negotiables in partners(1:09:16) – Why attraction feels uncontrollable(1:16:23) – Ending friendships that no longer serve(1:21:00) – Personal growth focus right nowWatch full episodes on: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@seankim⁠⁠⁠⁠⁠⁠⁠Connect on IG: ⁠⁠⁠⁠⁠⁠https://instagram.com/heyseankim

I'm psyched to welcome Andy Hall of The Infamous Stringdusters to Roadcase!!  The Stringdusters are celebrating their 20th year as a band and they've got a new album, 20/20, coming out February 13 to mark this special occasion.Andy talks to me about the evolution of the band — their roots in progressive bluegrass, and how they all came together — and we go deep into that collaborative vibe that makes the Stringdusters so special. The Stringdusters is one of my favorite bands, and I'm delighted to have Andy on the show. You can check out this one by clicking on that link in the bio — and stay tuned for more special coverage of the Dusters coming up next week!  =======================================Episode Chapters:00:00:00 Episode Intro with Host Josh Rosenberg00:04:15 Introducing Andy Hall00:07:21 Post-Tour Recovery and Mental Decompression00:10:22 Curating a Balanced Home Life00:13:20 20th Anniversary Reflections and New Album Insights00:16:06 Song Selection and Creative Process00:19:12 The Dynamics of Band Collaboration00:21:55 Navigating the Music Industry Changes00:24:59 Business Strategies for Success00:27:53 The Energy of Live Performances00:31:11 Evolving Live Show Philosophy00:38:16 The Evolution of Bluegrass Performance00:45:13 Adapting to Different Performance Environments00:48:17 The Journey to Mastering the Dobro01:00:14 From Upstate New York to Bluegrass Stardom01:06:51 The Evolution of Jamming and Collaboration01:08:24 Living the Colorado Lifestyle01:09:45 The Influence of Colorado on Bluegrass01:10:30 Balancing City Life and Nature01:11:49 Skiing Adventures and Local Favorites01:13:38 The Intersection of Music and Skiing01:15:36 Creating Music in Beautiful Settings01:17:03 Exploring Themes of Struggle and Positivity in Music01:23:15 The Impact of AI on Music Creation01:30:32 The Joy of the Artistic Process=======================================For more information on Roadcase:https://linktr.ee/roadcasepod and https://www.roadcasepod.comOr contact Roadcase by email:  info@roadcasepod.comRoadcase theme music:  "Eugene (Instrumental)" by Waltzer

  Guest: Dr. Steven Lytle, Founder of Sparrow House Counseling   If you'd like to watch this podcast, check out the PCA YouTube page.   Dr. Lytle and I will spend two weeks taking a deep dive into how divorce impacts children by examining the research and evidence presented in Elizabeth Marquardt's power book Between Two Worlds: The Inner Lives of Children of Divorce. While this book examines the kid's perspective of how divorce affects their world, as parents we need to understand this - there are conversations that we need to have and decisions we need to make as parents to better equip our children to better wrestle with the realities that they are facing.   Divorce literally changes the structure of childhood - regardless of whether it was a “good” divorce, or “bad” divorce, from the child's perspective, divorce creates two new and different realities that they must now cope with and, in many regards, learn to manage at a very young age.    Dr. Lytle says that as children learn to manage the two new realities, many of them become “cameleons” - meaning that they learn to change to fit into the two different realities. Many times children learn to lie to their parents in an effort to protect one or both from the harmful effects of the other parent. Interesting note from the book, the #1 stress of children of divorce is trying to protect the feelings of their mom.   Dr. Lytle points out that while there is no agenda in this book, the evidence does point to the devastating effects of divorce on children, which should be something that parents consider before ending their marriage.   Dr. Lytle points out that many parents take themselves out of community because of their divorce. When things are difficult, that is the time for parents to lean into a loving and caring community. Children of divorce often struggle with trust issues. Parents should make sure that their children are surrounded by other loving and trustworthy adults - the church is so important for children…and adults…during this difficult time. The book that I studied in a college class that is still powerful, just not written from a Christian perspective is The Unexpected Legacy of Divorce: The 25 Year Landmark Study by Judith Wallerstein.

This issue will review: 1.     Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial 2.     Impact of Oral Semaglutide on Kidney Outcomes in People with Type 2 Diabetes: Results from the SOUL Randomized Trial 3.     The effect of substituting water for artificially sweetened beverages on glycemic and weight measures in people with type 2 diabetes: The Study of Drinks with Artificial Sweeteners (SODAS), a randomized trial 4.     Effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults: a meta-analysis of randomized trials Trial Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. For more information about each of ADA's science and medical journals, please visit Diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health

Fatburger files for bankruptcy as GLP-1 weight-loss drugs reshape eating habits, while Starbucks experiments with protein coffee to keep up with changing demand. Meanwhile, Amazon announces plans to shut down all Amazon Go and Amazon Fresh stores, signaling a major retail pivot. Lou also breaks down how cold weather impacts strawberry production—making them sweeter—and takes a look at Chick-fil-A’s three new test menu items.See omnystudio.com/listener for privacy information.

Summary In this episode, Justin Townsend and Adam Berkelmans explore the significance of freezing as a method of food preservation. They discuss the historical context of freezing, the science behind how freezing affects food, and practical tips for safe freezing practices. The conversation also covers the different types of freezers, the impact of air exposure on food quality, and best practices for freezing various types of food. The episode concludes with insights on managing freezer inventory effectively. - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Leave a Review of the Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Buy our Wild Fish and Game Spices⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Art of Venison Sausage Making Meat Tracker Magnet⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Chapters 00:00 The Importance of Freezing in Food Preservation 05:30 Understanding the Science of Freezing 08:01 Freezer Safety and Best Practices 10:22 Types of Freezers and Their Impact 13:36 The Effects of Air Exposure and Freezer Burn 15:24 Effective Food Wrapping Techniques 19:05 Freezing Different Types of Food 23:46 Managing Your Freezer Inventory 30:11 Conclusion and Next Steps in Preservation Takeaways Freezing is a common yet often overlooked method of food preservation. Historically, freezing was about stability rather than extreme cold. The introduction of home freezers changed food handling dynamics significantly. Freezing affects food texture due to ice crystal formation. Freezer safety is more about handling than arbitrary timelines. Air exposure leads to freezer burn, which is a form of dehydration. Vacuum sealing is one of the best methods to prevent freezer burn. Different foods require different freezing techniques for optimal preservation. Labeling and organizing your freezer can prevent waste and improve efficiency. Freezing should be treated as a skill to maximize its benefits. Keywords freezing, food preservation, freezer safety, wild food, freezing techniques, food storage, freezer burn, preservation methods, wild pantry, food science Learn more about your ad choices. Visit megaphone.fm/adchoices

Find Allan: https://www.moviemonstersinc.comFind Steven: https://www.patreon.com/cw/kostanskiskryptFind us: vh-us.com 

Principle 6 Ep 5 The little things we do as parents make a huge difference. Today, Leslie shares stories and lessons learned from her dear father. Find Leslie at lesliekkg@gmail.com

In this episode of The Dairy Podcast Show, Dr. Jennifer Spencer and Dr. Juan Piñeiro from Texas A&M AgriLife discuss how highly pathogenic avian influenza may affect dairy cattle reproduction. They explain why disease-related inflammation can reduce conception rates and increase services per conception in cows and heifers. The conversation explores early research findings, data challenges, and the importance of biosecurity in dairy operations. Learn how reproductive performance may lag even after recovery from disease. Listen now on all major podcast platforms!"When cows experience systemic illness, energy is redirected toward immune defense, which reduces the biological resources available for normal reproductive function."Meet the guest: Dr. Jennifer Spencer is an Associate Professor and Extension and Research Dairy Specialist with Texas A&M AgriLife, focusing on dairy reproduction, endocrinology, and herd management strategies. Dr. Juan Piñeiro is an Associate Professor and Extension Dairy Specialist at Texas A&M University with expertise in disease prevention, biosecurity, and applied dairy research. Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:50) Introduction(05:46) Reproduction concerns(09:20) Early findings(11:52) Impact on the heifer(17:05) Inflammation link(25:10) Practical takeaways(31:07) Closing thoughtsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo* Priority IAC* Lallemand* Afimilk* Agri-Comfort* Jones-Hamilton Co.* Evonik* CowManager- Protekta- DietForge- Berg + Schmidt- BoviSync- Natural Biologics- AHV- dsm-firmenich- SmaXtec

Series Title: Raising Godly Children in a Godless CultureSermon Title: The Effects of Godly DisciplineLearn more about us at livingstonescma.org.

Sometimes, the best stories are embellished but grounded in a little bit of truth… Join as we peel back the myth that poults drown when they look up at rainfall.   Resources:    Boone, W. W., et al. (2025). Effects of temperature and precipitation on wild turkey brood survival in the southeastern United States. Wildlife Society Bulletin, 49, e70003.   Healy, W. M., & Nenno, E. S. (1985). Effect of weather on wild turkey poult survival. Wildlife Society Bulletin, 1985, 91-101.   Roberts, S. D., & Porter, W. F. (1998). Influence of temperature and precipitation on survival of wild turkey poults. The Journal of wildlife management, 1499-1505.    Wiley, J. W., & Wunderle Jr, J. M. (1993). The effects of hurricanes on birds, with special reference to Caribbean islands. Bird Conservation International, 3(4), 319-349.   Our lab is primarily funded by donations. If you would like to help support our work, please donate here: http://UFgive.to/UFGameLab   We've launched our second online wild turkey course  ! Enroll in  Wild Turkey Manager: Biology, History & Habitat to learn about the principal biology, mating, behavior, food selection, human dimensions, hunter interactions, and historical context of wild turkeys. This course is accredited by the Society of American Foresters as a Category 2 course worth 7 Continuing Forestry Education credits. Enroll now: https://tinyurl.com/WildTurkeyManagerBio   Be sure to check out our first comprehensive online wild turkey course featuring experts across multiple institutions that specialize in habitat management and population management for wild turkeys. Earn up to 20.5 CFE hours! Enroll Now!    Dr. Marcus Lashley @DrDisturbance, Publications Dr. Will Gulsby @dr_will_gulsby, Publications Turkeys for Tomorrow @turkeysfortomorrow  UF Game Lab @ufgamelab, YouTube   Want to help wild turkey conservation? Please take our quick survey to take part in our research!   Do you have a topic you'd like us to cover? Leave us a review or send us an email at wildturkeyscience@gmail.com!   Watch these podcasts on YouTube   Please help us by taking our (quick) listener survey - Thank you!    Check out the DrDisturbance YouTube channel! DrDisturbance YouTube   Want to help support the podcast? Our friends at Grounded Brand have an option to donate directly to Wild Turkey Science at checkout. Thank you in advance for your support!   Leave a podcast rating for a chance to win free gear!   This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.    Music by Artlist.io Produced & edited by Charlotte Nowak  

“Say you've calculated your price and it comes out at £120,121.  Most would round it down to £120,000.  That's completely wrong.”  That's what Robert Cialdini told me on the latest episode of Nudge.  He also explained why the Prime energy drink first succeeded and then flopped.  How Disney kept us hooked on classic movies.  And how he applies the authority bias to sell his own products.  ---  Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults See Agent Spark in action at ⁠gwi.com/spark⁠ Read Cialdini's bestseller Influence: https://amzn.to/4prHb7Y Read the new and expanded Influence: https://amzn.to/43TY0jI Read Pre-Suasion: https://amzn.to/48hA6Qr  Read Yes! (Containing 60 Psyc-Marketing Tips): https://amzn.to/48ddNNf  Join 10,226 readers of my newsletter: https://www.nudgepodcast.com/mailing-list  Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/  --- Today's sources:  Cialdini, R. B. (2021). Influence: The psychology of persuasion (New & expanded ed.). Harper Business. Dunn, E. W., & Norton, M. I. (2013). Happy money: The science of happier spending. Simon & Schuster. Nelissen, R. M. A., & Meijers, M. H. C. (2011). Social benefits of luxury brands as costly signals of wealth and status. Evolution and Human Behavior, 32(5), 343–355. West, S. G. (1975). Increasing the attractiveness of college cafeteria food: A reactance theory perspective. Journal of Applied Psychology, 60(5), 656–658. Wilson, P. R. (1968). Perceptual distortion of height as a function of ascribed academic status. Journal of Social Psychology, 74(1), 97–102. Worchel, S., Lee, J., & Adewole, A. (1975). Effects of scarcity on value perception: The cookie-jar study. Journal of Personality and Social Psychology, 31(5), 791–799.

Sometimes, the best stories are embellished but grounded in a little bit of truth… Join as we peel back the myth that poults drown when they look up at rainfall.   Resources:    Boone, W. W., et al. (2025). Effects of temperature and precipitation on wild turkey brood survival in the southeastern United States. Wildlife Society Bulletin, 49, e70003.   Healy, W. M., & Nenno, E. S. (1985). Effect of weather on wild turkey poult survival. Wildlife Society Bulletin, 1985, 91-101.   Roberts, S. D., & Porter, W. F. (1998). Influence of temperature and precipitation on survival of wild turkey poults. The Journal of wildlife management, 1499-1505.    Wiley, J. W., & Wunderle Jr, J. M. (1993). The effects of hurricanes on birds, with special reference to Caribbean islands. Bird Conservation International, 3(4), 319-349.   Our lab is primarily funded by donations. If you would like to help support our work, please donate here: http://UFgive.to/UFGameLab   We've launched our second online wild turkey course  ! Enroll in  Wild Turkey Manager: Biology, History & Habitat to learn about the principal biology, mating, behavior, food selection, human dimensions, hunter interactions, and historical context of wild turkeys. This course is accredited by the Society of American Foresters as a Category 2 course worth 7 Continuing Forestry Education credits. Enroll now: https://tinyurl.com/WildTurkeyManagerBio   Be sure to check out our first comprehensive online wild turkey course featuring experts across multiple institutions that specialize in habitat management and population management for wild turkeys. Earn up to 20.5 CFE hours! Enroll Now!    Dr. Marcus Lashley @DrDisturbance, Publications Dr. Will Gulsby @dr_will_gulsby, Publications Turkeys for Tomorrow @turkeysfortomorrow  UF Game Lab @ufgamelab, YouTube   Want to help wild turkey conservation? Please take our quick survey to take part in our research!   Do you have a topic you'd like us to cover? Leave us a review or send us an email at wildturkeyscience@gmail.com!   Watch these podcasts on YouTube   Please help us by taking our (quick) listener survey - Thank you!    Check out the DrDisturbance YouTube channel! DrDisturbance YouTube   Want to help support the podcast? Our friends at Grounded Brand have an option to donate directly to Wild Turkey Science at checkout. Thank you in advance for your support!   Leave a podcast rating for a chance to win free gear!   This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org.    Music by Artlist.io Produced & edited by Charlotte Nowak  

In this episode of the Flex Diet Podcast, I sit down with Dr. Cas Fuchs from Maastricht University to dive into the science behind cold water immersion. We discuss its impact on muscle recovery, protein synthesis, and overall performance. Dr. Fuchs shares his latest research findings, debunking common myths and providing actionable insights for athletes and fitness enthusiasts.Plus, we touch on the effects of different carbohydrates on glycogen resynthesis and liver function. Whether you're a gym-goer or a seasoned athlete, this episode is packed with valuable information to optimize your training and recovery strategies.Sponsors:Fitness Insider Newsletter: https://miketnelson.com/Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:02:15 Starting the Discussion with Dr. Fuchs03:05 Research on Cold Water Immersion04:39 Mechanisms and Effects of Cooling on Muscle Recovery12:08 Long-Term Effects of Cold Water Immersion24:01 Comparing Cooling and Heating Protocols32:35 Placebo Effects and Practical Applications37:57 Debunking Cold Water Immersion for Fat Loss41:01 Exploring the Effects of Cold Water Immersion on Endurance41:50 The Role of Temperature in Muscle Physiology42:40 Practical Applications of Cold Water Immersion44:43 The Myth of Cooling Devices for Performance Enhancement48:37 Pre-Exercise Cold Water Immersion: Benefits and Drawbacks50:58 Glycogen Resynthesis and Carbohydrate Types01:02:50 Recent Research on Breakfast and Liver Glycogen01:06:13 Upcoming Studies and Bodybuilder Research01:09:10 Cold Water Immersion Tips for Gym Goers01:10:40 Conclusion and Contact Information Flex Diet Podcast Episodes You May Enjoy:Episode 202: Cold water immersion and the body's regulation systems: An interview with Dr. Dwayne JacksonYouTube: https://youtu.be/3UfPcOJdmIA?si=Vu4FT12Z5gd4JXkxEpisode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil BattersonYouTube: https://youtu.be/PPZyO1nxSPA?si=7BjCBIQBbs7srclyConnect with Cas:Instagram: https://www.instagram.com/casfuchsLinkedIn: https://www.linkedin.com/in/casfuchsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

Today, in Acts chapter nine, the Lord has appeared to Saul. In an abrupt change of events Saul is no longer the persecutor of Christians but now proclaiming that Jesus is the Son of God. It is a huge change of direction for Saul's life. The change was dramatic. And as Saul continued to grow in the Lord, his preaching became more powerful. To support this ministry financially, visit: https://www.oneplace.com/donate/621/29?v=20251111

In this solo episode, I would like to introduce the theme for January on The Transform Your Mind Podcast. I know we are almost at the end of the month, but I wanted to explain why I grouped these women together. Each of these interviews highlights the effects of childhood trauma in our adult lives.  And what's been so powerful about these conversations is how trauma shows up—not only in pain—but in pleasure, intimacy, and identity.Pamela Madsen: Pamela Madsen is a noted sex therapist specializing in somatic healing. She is renowned for creating safe spaces for women to explore their pleasure and reclaim their sexual identities through transformative retreats and therapeutic work.Andrea Lee: Andrea Lee is a courageous survivor of childhood trauma. Her journey through years of therapy and healing has empowered her to help others through volunteering at a rape crisis center, providing support and guidance to women facing similar experiences of abuse.Vanessa Bennett: Vanessa Bennett challenges traditional beliefs about motherhood. Her work focuses on dismantling the "motherhood myth," urging mothers to balance identity and personal joy without succumbing to generational sacrifices of self-worth.So, when we look at these three conversations together, a pattern emerges:How we learned to experience pleasureHow we learned to disconnect from our bodiesHow we learned to abandon ourselves for othersResources:Listen to Pamela Madsen's episode: Transform Your Mind Podcast YouTubeMore episodes and stories on Spotify: Transform Your Mind Podcast SpotifyTune into this episode for inspiring tales of transformation and healing from those who have reshaped their lives beyond childhood trauma. Experience these powerful narratives on YouTube or Spotify and stay connected for more thought-provoking episodes of "Transform Your Mind to Transform Your Life." See this video on The Transform Your Mind YouTube Channel https://www.youtube.com/@MyhelpsUs/videosTo see a transcripts of this audio as well as links to all the advertisers on the show page https://myhelps.us/Follow Transform Your Mind on Instagram https://www.instagram.com/myrnamyoung/Follow Transform Your mind on Facebookhttps://www.facebook.com/profile.php?id=100063738390977Please leave a rating and review on iTunes https://podcasts.apple.com/us/podcast/transform-your-mind/id1144973094 https://podcast.feedspot.com/personal_development_podcasts/

A Dane County village plans to reverse its decision to remove fluoride from its water. That's after one of the policy's advocates lost his seat in a recall election. we'll hear from our politics team on a busy week at the state Capitol. And, in his first year back in office, President Trump has shaken up America's education system. His push to end diversity initiatives has won praise from many conservatives in Wisconsin.

In this episode, my guest is Alex Tarnava, published researcher and inventor of Hydrogen Water Tablets. We talk about hydrogen as a lifestyle intervention, how long it takes to see results, whether it can help with weight loss, and what improvements older adults might experience. Alex explains the different sources of hydrogen, the effects of hydrogen inhalation, common issues with devices, and how to use hydrogen safely in daily life.

 Hello, and welcome to the Reloading Podcast here on the Firearms Radio Network.   Tonight the gang is talking with Jeff Siewert from Bulletology LLC.  Jeff's history in reloading and Ballistics What is Bulletology LLC? What resources do you offer for people to read/watch? Is there one thing you've learned on your journey that just blew your primers right out of their pockets? Where is a good starting point for someone looking to go from being just a reloader, to a “handloader”?   Cartridge case Design of the case Quality of the case Case inspection Case preparation Sizing of the case  Priming Case rim Thickness Priming systems Primers Primer seating depth Powder Selection Difference in powders Charge weights (accuracy) Why some powders are more accurate Bullet Different types What are more accurate What makes a bullet accurate Seating of the bullet Crimping or not Taper crimping Pressures How is a handloader to test for pressure Primer condition Case head expansion Bolt swipe/extractor swipe Effects on accuracy   Cartridge corner:    Suicide hotline 988 or 800-273-8255 https://walkthetalkamerica.org/ For Active Military or veterans, www.militaryonesource.com   Reviews:   Reloading Podcast Merch link   Please remember to use the affiliate links for Amazon and Brownells from the Webpage  it really does help the show and the network. Also visit https://huntshootoffroad.com/shop/ and use code RLP10 to save 10%on your Brass Goblin gear.   Patreons  New Patreons:  Current Patreons: Aaron R, AJ, Alexander R, Anthony B, Mr. Anonymoose, bt213456, Bill N, Brian M, Carl K, Chris S, KC3FHH, Ryan J, D MAC, David S, Drew, Eric S, Fatelvis111 Gerrid M, Jack B, Jason R, Jim M, Joel L, John C, Kalroy, Jason R. Joseph B, Brewer Bill, Larry C, Lonnie K, Mark H, Mark K, Vic T., Matthew T, David D, michael sp, Mike St, Mitchell N, Nick M, Nick R, N7FFL, Paul N, Peter D, Richard C, Riley S, Robert F, Russ H, Socal Reloader RP, T-Rex, Tony S, Winfred C RLP pledge link   Thank you for listening.   How to get in contact with us: Google Voice # 608-467-0308 Reloading Podcast website. Reloading Podcast Facebook Reloading Podcast on Instagram Reloading Podcast on MeWe Reloading Podcast on Discord The Reloading Room  Buckeye Targets  

In this episode, Sathiya discusses the importance of optimizing the brain to achieve freedom from pornography addiction. He explains the detrimental effects of pornography on the brain, including desensitization, sensitization, hypofrontality, and reduced stress response. Sathiya emphasizes the power of neuroscience principles, such as the idea that neurons that fire together wire together, and provides practical strategies for breaking the cycle of addiction. He also highlights the significance of optimizing sleep to enhance brain health and decision-making capabilities. Know more about Sathiya's work: Join DEEP CLEAN SIGNATURE PROGRAM Join Deep Clean Inner Circle - The Brotherhood You Neeed (+ get coached by Sathiya) For Less Than $2/day Submit Your Questions (Anonymously) To Be Answered On The Podcast Get A Free Copy of The Last Relapse, Your Blueprint For Recovery Watch Sathiya on Youtube For More Content Like This Chapters: (00:00) Understanding the Brain's Role in Habits (02:48) The Effects of Pornography on the Brain (04:35) Rewiring the Brain: Breaking Associations (07:57) Disrupting Circuits: Taking Action for Change (10:22) Optimizing Sleep for Brain Health

Plus, we smell how we smell, stop trying to hide it

The Trump administration has made changes to how the federal government approaches diversity, equity, and inclusion programs, using executive actions, funding rules, and legal challenges that are reshaping how colleges operate. In response, campuses across the country are reassessing these programs — some ending them, others renaming offices or pausing services as they navigate new legal and funding realities. Professor Anthony Hernandez shares what he learned from a listening tour across New Mexico, California, Texas, and Wisconsin, where he spoke with students and educators experiencing these shifts firsthand. He explains what's at stake for Hispanic-Serving Institutions and why these issues matter for college access, upward mobility, and the broader civic landscape.  For more on this topic: Read Hernandez's op-ed in USA Today: Trump education cuts quietly declare that opportunity should be rationed on race  Check out his op-ed in the Chicago Tribune: America cannot compete globally if it undermines its own people Read his op-ed in The Fulcrum: Tennessee's Attack on Federal Support for Hispanic-Serving Colleges Hurts Us All  

Timestamps: 0:00 Windows; a trick of Mephistopheles 0:07 Windows 11 bug prevents Shut Down 1:23 Data centers get 70% of RAM in 2026 2:38 Google appeals old monopoly ruling 4:55 QUICK BITS INTRO 5:06 Spotify price hike 5:43 Musk plans to beat Intel, AMD 6:26 xAI datacenter's sketchy power 7:04 Healing spray! 7:42 TikTok microdrama app NEWS SOURCES: https://lmg.gg/77HAl Learn more about your ad choices. Visit megaphone.fm/adchoices

My Love in you causes the breakthrough.For the full written message and corresponding Scriptures, head to CurlyNikki.com.This is moment-to-moment witnessing. I share as they come.This is no longer just GoOD mornings.This is the Eternal Dawn.COMPLETION.I love you

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you'll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption determines addiction risk, and how nicotine affects learning, memory, motivation, and mood. The conversation also covers sleep optimization, mitochondrial signaling, tolerance, cycling strategies, and why modern regulation often slows innovation in functional medicine, anti aging science, and human performance.You'll Learn: • Why nicotine itself is not the same as smoking or vaping • How delivery speed changes addiction risk and brain response • How nicotine supports learning, focus, and neuroplasticity • Why acetylcholine matters for memory and brain optimization • How to think about dosing, cycling, and tolerance safely • How nicotine stacks with caffeine, nootropics, and Danger Coffee • The relationship between nicotine, sleep architecture, and REM • Why harm reduction matters for longevity and mitochondrial health • How nicotine fits into a Smarter Not Harder biohacking strategy Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -Lucy! Get a 20% discount by using code ‘Dave' at https://lucy.co/# Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine podcast, nicotine nootropic, oral nicotine benefits, nicotine brain optimization, nicotine acetylcholine dopamine, nicotine learning memory, nicotine addiction risk, nicotine pouches vs smoking, LUCY nicotine, david renteln lucy, david renteln nicotine, lucy nicotine pouches, harm reduction nicotine, nicotine biohacking, nicotine human performance, nicotine longevity, nicotine neuroplasticity, nicotine sleep optimization, nicotine tolerance cycling, caffeine nicotine stack, danger coffee nicotine, dave asprey nicotine, dave asprey lucy, nootropics nicotine, functional medicine nicotine Resources: • HeartMath | Go to https://www.heartmath.com/dave to save 15% off. • LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:10 – Origin Story 2:20 – Product Forms & Usage 3:52 – Effects & Mechanisms 9:21 – Dosing & Addiction 15:33 – Memory & Cognitive Benefits 18:57 – Personality & Stacking 21:41 – Quitting Smoking 24:39 – Government Regulation 32:00 – Addiction Philosophy 35:30 – Behavior Change & Routines 39:08 – Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, my guest is Dr. Wendy Suzuki, PhD, a professor of neural science and psychology at New York University. We discuss simple, daily habits to improve focus, memory and overall cognitive performance. Dr. Suzuki explains how exercise directly enhances brain function—both the immediate benefits of a single workout and long-term support for cognitive health. We also discuss how meditation, verbal affirmations, sleep and other behavioral practices positively influence mood and stress regulation. Episode show notes: https://go.hubermanlab.com/7gTmlIR Join the Huberman Lab Neural Network Newsletter: https://www.hubermanlab.com/newsletter Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Wendy Suzuki (00:00:21) What Makes Moments Memorable? (00:02:24) Memory & Hippocampus, Imagination (00:05:35) Sponsor: BetterHelp (00:06:37) One-Trial Learning, Fear (00:08:10) Exercise Effects on Focus, Attention & Memory (00:12:31) Brain-Derived Neurotrophic Factor (BDNF) & Exercise (00:15:10) Sponsor: AG1 (00:16:55) Tools: Cardiovascular Exercise; 10-Minute Walk & Mood (00:18:43) How Exercise Increases BDNF (00:20:47) Adults, Neuron Growth, Hippocampus (00:22:51) Exercise Effects on Memory, Tool: Morning Exercise (00:26:08) Exercise & Long-term Effects on Cognition, Older Adults (00:27:56) Minimum Exercise For Cognitive Benefits (Adults, 30s-50s) (00:32:03) Sponsor: Eight Sleep (00:33:22) Increase Exercise For Greater Cognitive Benefits (00:35:30) Affirmations, Exercise, Mood, IntenSati (00:37:37) Meditation & Benefits, Tool: Brief Meditation (00:39:32) Tools to Improve Attention Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices