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THE BETTER BELLY PODCAST - Gut Health Transformation Strategies for a Better Belly, Brain, and Body
298// Low Stomach Acid Explained: A Real Root Cause of Acid Reflux, Candida, Constipation, and SIBO

THE BETTER BELLY PODCAST - Gut Health Transformation Strategies for a Better Belly, Brain, and Body

Play Episode Listen Later Jan 8, 2026 22:43


Are you struggling with acid reflux, bloating, constipation, SIBO, or candida overgrowth?Do you feel like you've tried everything to heal — supplements, protocols, elimination diets, practitioners — and they either didn't help, or the second you stopped doing it, all your symptoms came back?If that's you, there's a very real chance you're dealing with something you may have never heard of before: low stomach acid.Yes, LOW stomach acid.Today's episode is kicking off a series I'm running this January - February called the Real Root Causes series. And I'm starting with low stomach acid on purpose.Because while low stomach acid is something I reference constantly when working with chronic gut issues… here's the plot twist:-- it's still not a REAL root cause.Low stomach acid doesn't just happen. And if you don't understand why it's happening, you'll stay stuck in the cycle of temporary fixes and recurring symptoms.So today, I'm going to break down the REAL root causes to low stomach acid. I'll be covering topics like:Why low stomach acid happensMy favorite at-home low stomach acid testSigns of low stomach acidWhy apple cider vinegar for low stomach acid is not safe until you test this ONE thingThe REAL root causes of low stomach acidHow to test for the root causes of low stomach acidAnd the exact low stomach acid remedies and protocols you'll need to permanently reverse it - so you can finally get rid of your acid reflux, constipation, SIBO, and candida infection, tooIf all you've ever been told to do to help your stomach acid or digestion is drink lemon water, apple cider vinegar, or take HCl supplements, then this episode is for you.TIMESTAMPS:00:00 - Introduction and Podcast Overview00:21 - The Real Root Causes Series01:54 - Understanding Low Stomach Acid03:50 - Symptoms and Misconceptions of Low Stomach Acid07:05 - Root Causes of Low Stomach Acid09:27 - Testing and Protocols for Low Stomach Acid20:17 - Conclusion and Next Episode PreviewEPISODES MENTIONED:233// H. Pylori: Symptoms of H. Pylori, How to Interpret H. Pylori Test Results, and Why H. Pylori Treatments Fail159// Copper Toxicity: A Hidden Cause Behind Constipation & PMS287// How to safely get off PPI's and reverse acid reflux naturallyHEAL YOUR GUT TODAY!Option #1)

The Nutritional Therapy and Wellness Podcast
Ep 080: Rapid Replays - Digestive Hell - A Legacy Lecture from NTA Founder Gray Graham

The Nutritional Therapy and Wellness Podcast

Play Episode Listen Later Jan 4, 2026 62:14


When new people find the Nutritional Therapy and Wellness Podcast, they ask, "Where do I start?" While we'd love for you to go back to the beginning and take them all in, this is for those who need a quick catch-up. We're doing a Rapid Replay Series of condensed episodes, including the most popular episodes according to streams and downloads, and a few of our team's personal favorites.   In this replay episode of The Nutritional Therapy and Wellness Podcast, host Jamie Belz, FNTP, MHC, brings back a historical lecture given by the founder of The Nutritional Therapy Association, Gray Graham. Gray discusses the optimal function of digestion in a way you've never heard it explained. Listen to this, then come back tomorrow to catch the next episode as Gray explains digestive dysfunction.   Optimal digestion is crucial for vitality. It ensures that the body efficiently breaks down food into nutrients, which are then absorbed and utilized for energy, growth, and cellular repair. Proper digestion supports a strong immune system, maintains a healthy gut microbiome, and helps prevent gastrointestinal disorders. Additionally, it plays a significant role in mental health, as the gut is often referred to as the "second brain" due to its impact on mood and cognitive function. Therefore, maintaining optimal digestion is vital for promoting physical and mental health, enhancing quality of life, and preventing chronic diseases. The follow-up to yesterday's explanation of how digestion works when functioning optimally, today's episode continues along the journey of digestion, explaining that if someone is not properly digesting their food, they will not be able to absorb and assimilate the nutrients from the foods they are eating, regardless of how healthful those foods are. Gray walks you through "Digestive Hell" – the myriad of diseases, conditions, and other unpleasantries that arise from a suboptimal digestive system.   Every cell in an organism's tissues, organs, and systems relies on the ability to absorb nutrients from food properly. Factors such as stress, poor eating habits, gallbladder removal, and reduced stomach acid (HCl) levels can hinder digestion. Given the critical role of nutrition in maintaining healthy cells, any disruption in digestion can be harmful in various ways. A dysfunctional digestive system catalyzes a domino effect, impacting the functioning of other bodily systems.   Topics Discussed: – Recap of optimal digestion – Start of digestive dysfunction – "Where's 'Digestive Hell'?" – Distraction, stress, sympathetic state – Pancreatic amylase – Dysbiosis, yeast, pathogens – It's all about acid/pH levels – Macronutrient degradation – Inputs for the production of HCl – Things that cause hypochlorhydria (stress, too much protein, zinc, other nutrient deficiencies, allergies…) – Dr. Jonathan Wright, Heidelberg Test, hypochlorhydria, pH for proper hormone function, and enzymatic action – Pasteur vs. Bechamp / Microorganisms vs. Terraine (Which is to blame?) – H. pylori – Heartburn, acid reflux, GERD, ulcers – Homework/experiment – Incomplete digestion, whole food particles in the small intestine – Gallbladder, bile, fats, cholecystokinin, liver, fat-free or low-fat diet as the cause of gallstones and gallbladder dysfunction, cholecystectomy (gallbladder removal) – Burping up fish oil and delayed-release fish oil – Undigested proteins, microvilli, leaky gut/gut permeability, immune dysfunction – Dr. Natasha Campbell-McBride, healing her autistic child, GAPS Diet – Large intestine/colon, ileocecal valve, dysbiosis, inflammation, diverticulitis, irritable bowel, Crohn's disease, celiac disease/gluten reactivity, hormones/endocrine system, enzymes, heart health, allergies, butyric acid, and foul-smelling feces   ________________________________________ Thanks for listening! If you like what you're hearing, please don't forget to subscribe and give us a five-star rating!

Let's Talk Wellness Now
Episode 250 -The Great Medical Deception

Let's Talk Wellness Now

Play Episode Listen Later Jan 2, 2026 49:27


Dr. DebWhat if I told you that the stomach acid medication you’re taking for heartburn is actually causing the problem it’s supposed to solve that your doctor learned virtually nothing about nutrition, despite spending 8 years in medical school. That the very system claiming to heal you was deliberately designed over a hundred years ago by an oil tycoon, John D. Rockefeller, to create lifelong customers, not healthy people. Last week a patient spent thousands of dollars on tests and treatments for acid reflux, only to discover she needed more stomach acid, not less. The medication keeping her sick was designed to do exactly that. Today we’re exposing the greatest medical deception in modern history, how a petroleum empire systematically destroyed natural healing wisdom turned medicine into a profit machine. And why the treatments, keeping millions sick were engineered that way from the beginning. This isn’t about conspiracy theories. This is a documented history that explains why you feel so lost about your own body’s needs welcome back to let’s talk wellness. Now the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb. And today we’re diving into how the Rockefeller Medical Empire systematically destroyed natural healing wisdom and replaced it with profit driven systems that keeps you dependent on treatments instead of achieving true health. If you or someone you love has been running to the doctor for every minor ailment, taking acid blockers that seem to make digestive problems worse, or feeling confused about basic body functions that our ancestors understood instinctively. This episode is for you. So, as usual, grab a cup of coffee, tea, or whatever helps you unwind. Settle in and let’s get started on your journey to reclaiming your health sovereignty all right. So here we are talking about the Rockefeller Medical Revolution. Now, what if your symptoms aren’t true diagnosis, but rather the predictable result of a medical system designed over a hundred years ago to create lifelong customers instead of healthy people. Now I learned this when I was in naturopathic school over 20 years ago. And it hasn’t been talked about a lot until recently. Recently. People are exposing the truth about what actually happened in our medical system. And today I want to take you back to the early 19 hundreds to understand how we lost the basic health wisdom that sustained humanity for thousands of years. Yes, I said that thousands of years. This isn’t conspiracy theory. This is documented history. That explains why you feel so lost when it comes to your own body’s needs. You know by the turn of the 20th century. According to meridian health Clinic’s documentation. Rockefeller controlled 90% of all petroleum refineries in America and through ownership of the Standard Oil Corporation. But Rockefeller saw an opportunity that went far beyond oil. He recognized that petrochemicals could be the foundation for a completely new medical system. And here’s what most people don’t know. Natural and herbal medicines were very popular in America during the early 19 hundreds. According to Staywell, Copper’s historical analysis, almost one half of medical colleges and doctors in America were practicing holistic medicine, using extensive knowledge from Europe and native American traditions. People understood that food was medicine, that the body had natural healing mechanisms, and that supporting these mechanisms was the key to health. But there was a problem with the Rockefeller’s business plan. Natural medicines couldn’t be patented. They couldn’t make a lot of money off of them, because they couldn’t hold a patent. Petrochemicals, however, could be patented, could be owned, and could be sold for high profits. So Rockefeller and Andrew Carnegie devised a systematic plan to eliminate natural medicine and replace it with petrochemical based pharmaceuticals and according to E. Richard Brown’s comprehensive academic documentation in Rockefeller, medicine men. Medicine, and capitalism in America. They employed the services of Abraham Flexner, who proceeded to visit and assess every single medical school in us and in Canada. Within a very short time of this development, medical schools all around the us began to collapse or consolidate. The numbers are staggering. By 1910 30 schools had merged, and 21 had closed their doors of the 166 medical colleges operating in 19 0, 4, a hundred 33 had survived by 1910 and a hundred 4 by 1915, 15 years later, only 76 schools of medicine existed in the Us. And they all followed the same curriculum. This wasn’t just about changing medical education. According to Staywell’s copper historical analysis. Rockefeller and Carnegie influenced insurance companies to stop covering holistic treatments. Medical professionals were trained in the new pharmaceutical model and natural solutions became outdated or forgotten. Not only that alternative healthcare practitioners who wanted to stay practicing in alternative medicine were imprisoned for doing so as documented by the potency number 710. The goal was clear, create a system where scientists would study how plants cure disease, identify which chemicals in the plants were effective and then recreate a similar but not identical chemical in the laboratory that would be patented. E. Richard Brown’s documents. The story of how a powerful professional elite gained virtual homogeny in the western theater of healing by effectively taking control of the ethos and practice of Western medicine. The result, according to the healthcare spending data, the United States now spends 17.6% of its Gdp on health care 4.9 trillion dollars in 2023, or 14,570 per person nearly twice as much as the average Oecd country. But it doesn’t focus on cure. But on symptoms, and thus creating recurring clients. This systematic destruction of natural medicine explains why today’s healthcare providers often seem baffled by simple questions about nutrition why they immediately reach for a prescription medication for minor ailments, and why so many people feel disconnected from their own body’s wisdom. We’ve been trained over 4 generations to believe that our bodies are broken, and that symptoms are diseases rather than messages, and that external interventions are always superior to supporting natural healing processes. But here’s what they couldn’t eliminate your body’s innate wisdom. Your digestive system still functions the same way it did a hundred years ago. Your immune system still follows the same patterns. The principles of nutrition, movement and stress management haven’t changed. We’ve just forgotten how to listen and respond. We’re gonna take a small break here and hear from our sponsor. When we come back. We’re gonna talk about the acid reflux deception, and why your cure is making you sicker, so don’t go away all right, welcome back. So I want to give you a perfect example of how Rockefeller medicine has turned natural body wisdom upside down, the treatment of acid, reflux, and heartburn. Every single day in my practice I see patients who’ve been taking acid blocker medications, proton pump inhibitors like prilosec nexium or prevacid for years, not for weeks, years, and sometimes even decades. They come to me because their digestive problems are getting worse, not better. They have bloating and gas and nutrition deficiencies. And we’re seeing many more increased food sensitivities. And here’s what’s happening in the Us. Most people often attribute their digestive problems to too much stomach acid. And they use medications to suppress the stomach acid, but, in fact symptoms of chronic acid, reflux, heartburn, or gerd, can also be caused by too little stomach acid, a condition called hyper. Sorry hypochlorhydria normal stomach acid has a Ph level of one to 2, which is highly acidic. Hydrochloric acid plays an important role in your digestion and your immunity. It helps to break down proteins and absorb essential nutrients, and it helps control viruses and bacteria that might otherwise infect your stomach. But here’s the crucial part that most people don’t understand, and, according to Cleveland clinic, your stomach secretes lower amounts of hydrochloric acid. As you age. Hypochlorhydria is more common in people over the age of 40, and even more common over the age of 65. Webmd states that the stomach acid can produce less acid as a result of aging and being 65 or older is a risk factor for developing hypochlorhydria. We’ve been treating this in my practice for a long time. It’s 1 of the main foundations that we learn as naturopathic practitioners and as naturopathic doctors, and there are times where people need these medications, but they were designed to be used short term not long term in a 2,013 review published in Medical News today, they found that hypochlorhydria is the main change in the stomach acid of older adults. and when you have hypochlorydria, poor digestion from the lack of stomach, acid can create gas bubbles that rise into your esophagus or throat, carrying stomach acid with them. You experience heartburn and assume that you have too much acid. So you take acid blockers which makes the underlying problem worse. Now, here’s something that will shock you. PPI’s protein pump inhibitors were originally studied and approved by the FDA for short-term use only according to research published in us pharmacists, most cases of peptic ulcers resolve in 6 to 8 weeks with PPI therapy, which is what these medications were created for. Originally the American family physician reports that for erosive esophagitis. Omeprazole is indicated for short term 4 to 8 weeks. That’s it. Treatment and healing and done if needed. An additional 4 to 8 weeks of therapy may be considered and the University of Minnesota College of Pharmacy, States. Guidelines recommended a treatment duration of 8 weeks with standard once a day dosing for a PPI for Gerd. The Canadian family physician, published guidelines where a team of healthcare professionals recommended prescribing Ppis in adults who suffer from heartburn and who have completed a minimum treatment of 4 weeks in which symptoms were relieved. Yet people are taking these medications for years, even decades far beyond their intended duration of use and a study published in Pmc. Found that the threshold for defining long-term PPI use varied from 2 weeks to 7 years of PPI use. But the most common definition was greater than one year or 6 months, according to the research in clinical context, use of Ppis for more than 8 weeks could be reasonably defined as long-term use. Now let’s talk about what these acid blocker medications are actually doing to your body when used. Long term. The research on long term PPI use is absolutely alarming. According to the comprehensive review published in pubmed central Pmc. Long-term use of ppis have been associated with serious adverse effects, including kidney disease, cardiovascular disease fractures because you’re not absorbing your nutrients, and you’re being depleted. Infections, including C. Diff pneumonia, micronutrient deficiencies and hypomagnesium a low level of magnesium anemia, vitamin, b, deficiency, hypocalcemia, low calcium, low potassium. and even cancers, including gastric cancer, pancreatic cancer, colorectal cancer. And hepatic cancer and we are seeing all of these cancers on a rise, and we are now linking them back to some of these medications. Mayo clinic proceedings published research showing that recent studies regarding long-term use of PPI medication have noted potential adverse effects, including risks of fracture, pneumonia, C diff, which is a diarrhea. It’s a bacteria, low magnesium, low b 12 chronic kidney disease and even dementia. And a 2024 study published in nature communications, analyzing over 2 million participants from 5 cohorts found that PPI use correlated with increased risk of 15 leading global diseases, such as ischemic heart disease. Diabetes, respiratory infections, chronic kidney disease. And these associations showed dose response relationships and consistency across different PPI types. Now think about this. You take a medication for heartburn that was designed for 4 to 8 weeks of use, and when used long term, it actually increases your risk of life, threatening infections, kidney disease, and dementia. This is the predictable result of suppressing a natural body function that exists for important reasons. Hci plays a key role in many physiological processes. It triggers, intestinal hormones, prepares folate and B 12 for absorption, and it’s essential for absorption of minerals, including calcium, magnesium, potassium, zinc, and iron. And when you block acid production, you create a cascade of nutritional deficiencies and immune system problems that often manifest as seemingly unrelated health issues. So what’s the natural approach? Instead of suppressing stomach acid, we need to support healthy acid production and address the root cause of reflux healthcare. Providers may prescribe hcl supplements like betaine, hydrochloric acid. Bhcl is what it’s called. Sometimes it’s called betaine it’s often combined with enzymes like pepsin or amylase or lipase, and it’s used to treat hydrochloric acid deficiency, hypochlorhydria. These supplements can help your digestion and sometimes help your stomach acid gradually return back to normal levels where you may not need to use them all the time. Simple strategies include consuming protein at the beginning of the meal to stimulate Hcl production, consume fluids separately at least 30 min away from meals, if you can, and address the underlying cause like chronic stress and H. Pylori infections. This is such a sore subject for me. So many people walk around with an H. Pylori infection. It’s a bacterial infection in the stomach that can cause stomach ulcers, causes a lot of stomach pain and burning. and nobody is treating the infection. It’s a bacterial infection. We don’t treat this anymore with antibiotics or antimicrobials. We treat it with Ppis. But, Ppis don’t fix the problem. You have to get rid of the bacteria once the bacteria is gone, the gut lining can heal. Now it is a common bacteria. It can reoccur quite frequently. It’s highly contagious, so you can pick it up from other people, and it may need multiple courses of treatment over a person’s lifetime. But you’re actually treating the problem. You’re getting rid of the bacteria that’s creating the issue instead of suppressing the acid. That’s not fixing the bacteria which then leads to a whole host of other problems that we just talked about. There are natural approaches to increase stomach acid, including addressing zinc deficiency. And since the stomach uses zinc to produce Hcl. Taking probiotics to help support healthy gut bacteria and using digestive bitters before meals can be really helpful. This is exactly what I mean about reclaiming the body’s wisdom. Instead of suppressing natural functions, we support them instead of creating drug dependency, we restore normal physiology. Instead of treating symptoms indefinitely, we address the root cause and help the body heal itself. In many cultures. Bitters is a common thing to use before or after a meal. But yet in the American culture we don’t do that anymore. We’ve not passed on that tradition. So very few people understand how to use bitters, or what bitters are, or why they’re important. And these basic things that can be used in your food and cooking and taking could replace thousands of dollars of medication that you don’t really need. That can create many more problems along the way. Now, why does your doctor know nothing about nutrition. Well, I want to address something that might shock you all. The reason your doctor seems baffled when you ask about nutrition isn’t because they’re not intelligent. It’s because they literally never learned this in medical school statistics on nutritional education in medical schools are staggering and help explain why we have such a health literacy crisis in America. According to recent research published in multiple academic journals, only 27% of Us. Medical schools actually offer students. The recommended 25 h of nutritional training across 4 years of medical school. That means 73% of the medical schools don’t even meet the minimum standards set in 1985. But wait, it gets worse. A 2021 survey of medical schools in the Us. And the Uk. Found that most students receive an average of only 11 h of nutritional training throughout their entire medical program. and another recent study showed that in 2023 a survey of more than a thousand Us. Medical students. About 58% of these respondents said they received no formal nutritional education while in medical school. For 4 years those who did averaged only 3 h. I’m going to say this again because it’s it’s huge 3 h of nutritional education per year. So let me put this in perspective during 4 years of medical school most students spend fewer than 20 h on nutrition that’s completely disproportionate to its health benefits for patients to compare. They’ll spend hundreds of hours learning about pharmaceutical interventions, but virtually no time learning how food affects health and disease. Now, could this be? Why, when we talk about nutrition to lower cholesterol levels or control your diabetes, they blow you off, and they don’t answer you. It’s because they don’t understand. But yet what they’ll say is, people won’t change their diet. That’s why you have to take medication. That’s not true. I will tell you. I work with people every single day who are willing to change their diet. They’re just confused by all the information that’s out there today about nutrition. And what diet is the right diet to follow? Do I do, Paleo? Do I do? Aip? Do I do carnivore? Do I do, Keto? Do I do? Low carb? There’s so many diets out there today? It’s confusing people. So I digress. But let’s go back. So here’s the kicker. The limited time medical students do spend on nutrition office often focuses on nutrients think proteins and carbohydrates rather than training in topics such as motivational interviewing or meal planning, and as one Stanford researcher noted, we physicians often sound like chemists rather than counselors who can speak with patients about diet. Isn’t that true? We can speak super high level up here, but we can’t talk basics about nutrition. And this explains why only 14% of the physicians believe they were adequately trained in nutritional counseling. Once they entered practice and without foundational concepts of nutrition in undergrad work. Graduate medical education unsurprisingly falls short of meeting patients, needs for nutritional guidance in clinical practice, and meanwhile diet, sensitive chronic diseases continue to escalate. Although they are largely preventable and treatable by nutritional therapies and dietary. Lifestyle changes. Now think about this. Diet. Related diseases are the number one cause of death in the Us. The number one cause. Yet many doctors receive little to no nutritional education in medical school, and according to current health statistics from 2017 to march of 2020. Obesity prevalence was 19.7% among us children and adolescents affecting approximately 14.7 million young people. About 352,000 Americans, under the age of 20, have been diagnosed with diabetes. Let me say this again, because these numbers are astounding to me. 352,000 Americans, under the age of 20, have been diagnosed with diabetes with 5,300 youth diagnosed with type, 2 diabetes annually. Yet the very professionals we turn to for health. Guidance were never taught how food affects these conditions and what drug has come to the rescue Glp. One S. Ozempic wegovy. They’re great for weight loss. They’re great for treating diabetes. But why are they here? Well, these numbers are. Why, they’re here. This is staggering to put 352,000 Americans under the age of 20 on a glp, one that they’re going to be on for the rest of their lives at a minimum of $1,200 per month. All we have to do is do the math, you guys, and we can see exactly what’s happening to our country, and who is getting rich, and who is getting the short end of the stick. You’ve become a moneymaker to the pharmaceutical industry because nobody has taught you how to eat properly, how to live, how to have a healthy lifestyle, and how to prevent disease, or how to actually reverse type 2 diabetes, because it’s reversible in many cases, especially young people. And we do none of that. All we do is prescribe medications. Metformin. Glp, one for the rest of your life from 20 years old to 75, or 80, you’re going to be taking medications that are making the pharmaceutical companies more wealth and creating a disease on top of a disease on top of a disease. These deficiencies in nutritional education happen at all levels of medical training, and there’s been little improvement, despite decades of calls for reform. In 1985, the National Academy of Sciences report that they recommended at least 25 h of nutritional education in medical school. But a 2015 study showed only 29% of medical schools met this goal, and a 2023 study suggests the problem has become even worse. Only 7.8% of medical students reported 20 or more hours of nutritional education across all 4 years of medical school. This systemic lack of nutrition, nutritional education has been attributed to several factors a dearth of qualified instructors for nutritional courses, since most physicians do not understand nutrition well enough to teach it competition for curriculum time, with schools focusing on pharmaceutical interventions rather than lifestyle medicine and a lack of external incentives that support schools, teaching nutrition. And ironically, many medical schools are part of universities that have nutrition departments with Phd. Trained professors who could fill this gap by teaching nutrition in medical schools but those classes are often taught by physicians who may not have adequate nutritional training themselves. This explains so much about what I see in my practice. Patients come to me confused and frustrated because their primary care doctors can’t answer basic questions about how food affects their health conditions. And these doctors aren’t incompetent. They simply were never taught this information. And the result is that these physicians graduate, knowing how to prescribe medications for diabetes, but not how dietary changes can prevent or reverse it. They can treat high blood pressure with pharmaceuticals, but they may not know that specific nutritional approaches can be equally or more effective. This isn’t the doctor’s fault. It’s the predictable result of medical education systems that was deliberately designed to focus on patentable treatments rather than natural healing approaches. And remember this traces back to the Rockefeller influence on medical education. You can’t patent an apple or a vegetable. But you can patent a drug now. Why can’t we trust most medical studies? Well this just gets even better. I need to address something that’s crucial for you to understand as you navigate health information. Why so much of the medical research you hear about in the news is biased, and why peer Review isn’t the gold standard of truth you’ve been told it is. The corruption in medical research by pharmaceutical companies is not a conspiracy theory. It’s well documented scientific fact, according to research, published in frontiers, in research, metrics and analytics. When pharmaceutical and other companies sponsor research, there is a bias. A systematic tendency towards results serving their interests. But the bias is not seen in the formal factors routinely associated with low quality science. A Cochrane Review analyzed 75 studies of the association between industry, funding, and trial results, and these authors concluded that trials funded by a drug or device company were more likely to have positive conclusions and statistically significant results, and that this association could not be explained by differences in risk of bias between industry and non-industry funded trials. So think about that. According to the Cochrane collaboration, industry funding itself should be considered a standard risk of bias, a factor in clinical trials. Studies published in science and engineering ethics show that industry supported research is much more likely to yield positive outcomes than research with any other sponsorship. And here’s how the bias gets introduced through choice of compartor agents, multiple publications of positive trials and non-publication of negative trials reinterpreting data submitted to regulatory agencies, discordance between results and conclusions, conflict of interest leading to more positive conclusions, ghostwriting and the use of seating trials. Research, published in the American Journal of Medicine. Found that a result favorable to drug study was reported by all industry, supported studies compared with two-thirds of studies, not industry, supported all industry, supported studies showed favorable results. That’s not science that’s marketing, masquerading as research. And according to research, published in sciencedirect the peer review system which we’re told ensures quality. Science has a major limitation. It has proved to be unable to deal with conflicts of interest, especially in big science contexts where prestigious scientists may have similar biases and conflicts of interest are widely shared among peer reviewers. Even government funded research can have conflicts of interest. Research published in pubmed States that there are significant benefits to authors and investigators in participating in government funded research and to journals in publishing it, which creates potentially biased information that are rarely acknowledged. And, according to research, published in frontiers in research, metrics, and analytics, the pharmaceutical industry has essentially co-opted medical knowledge systems for their particular interests. Using its very substantial resources. Pharmaceutical companies take their own research and smoothly integrate it into medical science. Taking advantage of the legitimacy of medical institutions. And this corruption means that much of what passes for medical science is actually influenced by commercial interests rather than pursuant of truth. Research published in Pmc. Shows that industry funding affects the results of clinical trials in predictable directions, serving the interests of the funders rather than the patients. So where can we get this reliable, unbiased Health information, because this is critically important, because your health decisions should be based on the best available evidence, not marketing disguised as science. And so here are some sources that I recommend for trustworthy health and nutritional information. They’re independent academic sources. According to Harvard Chan School of public health their nutritional, sourced, implicitly states their content is free from industry, influence, or support. The Linus Pauling Institute, Micronutrient Information Center at Oregon State University, which, according to the Glendale Community college Research Guide provides scientifically accurate information about vitamins, minerals, and other dietary factors. This Institute has been around for decades. I’ve used it a lot. I’ve gotten a lot of great information from them. Very, very trustworthy. According to the Glendale Community College of Nutrition Resource guide Tufts, University of Human Nutritional Research Center on aging is one of 6 human nutrition research centers supported by the United States Department of Agriculture, the Usda. Their peer reviewed journals with strong editorial independence though you must still check funding resources. And how do you evaluate this information? Online? Well, according to medlineplus and various health literacy guides when evaluating health information medical schools and large professional or nonprofit organizations are generally reliable sources, but remember, it is tainted by the Rockefeller method. So, for example, the American College of cardiology. Excuse me. Professional organization and the American Heart Institute a nonprofit are both reliable sources. Sorry about that of information on heart health and watch out for ads designed to look like neutral health information. If the site is funded by ads they should be clearly marked as advertisements. Excuse me, I guess I’m talking just a little too much now. So when the fear of medicine becomes deadly. Now, I want to address something critically important that often gets lost in conversations about health, sovereignty, and questioning the medical establishment. And while I’ve spent most of this episode explaining how the Rockefeller medical system has created dependency and suppressed natural healing wisdom. There’s a dangerous pendulum swing happening that I see in my practice. People becoming so fearful of pharmaceutical interventions that they refuse lifesaving treatments when they’re genuinely needed. This is where balance and clinical judgment become absolutely essential. Yes, we need to reclaim our basic health literacy and reduce our dependency on unnecessary medical interventions. But there are serious bacterial infections that require immediate antibiotic treatment, and the consequences of avoiding treatment can be devastating or even fatal. So let me share some examples from research that illustrate when antibiotic fear becomes dangerous. Let’s talk about Lyme disease, and when natural approaches might not be enough. The International Lyme Disease Association ilads has conducted extensive research on chronic lyme disease, and their findings are sobering. Ileds defines chronic lyme disease as a multi-system illness that results from an active and ongoing infection of pathogenic members of the Borrelia Brdorferi complex. And, according to ilads research published in their treatment guidelines, the consequences of untreated persistent lyme infection far outweigh the potential consequences of long-term antibiotic therapy in well-designed trials of antibiotic retreatment in patients with severe fatigue, 64% in the treatment arm obtained clinically significant and sustained benefit from additional antibiotic therapy. Ilas emphasizes that cases of chronic borrelia require individualized treatment plans, and when necessary antibiotic therapy should be extended their research demonstrates that 20 days of prophylactic antibiotic treatment may be highly effective for preventing the onset of lyme disease. After known tick bites and patients with early Lyme disease may be best served by receiving 4 to 6 weeks of antibiotic therapy. Research published in Pmc. Shows that patients with untreated infections may go on to develop chronic, debilitating, multisystem illnesses that is difficult to manage, and numerous studies have documented persistent Borrelia, burgdorferi infection in patients with persistent symptoms of neurological lyme disease following short course. Antibiotic treatment and animal models have demonstrated that short course. Antibiotic therapy may fail to eradicate lyme spirochetes short course is a 1 day. One pill treatment of doxycycline. Or less than 20 days of antibiotics, is considered a short course. It’s not long enough to kill the bacteria. The bacteria’s life cycle is about 21 days, so if you don’t treat the infection long enough, the likelihood of that infection returning is significant. They’ve also done studies in the petri dish, where they show doxycycline being put into a petri dish with active lyme and doxycycline does not kill the infection, it just slows the replication of it. Therefore, using only doxycycline, which is common practice in lyme disease may not completely eradicate that infection for you. So let’s talk about another life threatening emergency. C. Diff clostridia difficile infection, which represents another example where antibiotic treatment is absolutely essential, despite the fact that C diff itself is often triggered by antibiotic use. According to Cleveland clinic C. Diff is estimated to cause almost half a million infections in the United States each year, with 500,000 infections, causing 15,000 deaths each year. Studies reported by Pmc. Found thirty-day Cdi. Mortality rates ranging from 6 to 11% and hospitalized Cdi patients have significantly increased the risk of mortality and complications. Research published in Pmc shows that 16.5% of Cdi patients experience sepsis and that this increases with reoccurrences 27.3% of patients with their 1st reoccurrence experience sepsis. While 33.1% with 2 reoccurrences and 43.2% with 3 or more reoccurrences. Mortality associated with sepsis is very high within hospital 30 days and 12 month mortality rates of 24%, 30% and 58% respectively. According to the Cdc treatment for C diff infection usually involves taking a specific antibiotic, such as vancomycin for at least 10 days, and while this seems counterintuitive, treating an antibiotic associated infection with more antibiotics. It’s often lifesaving. Now let’s talk about preventing devastating complications. Strep throat infections. Provide perhaps the clearest example of when antibiotic treatment prevents serious long-term consequences, and, according to Mayo clinic, if untreated strep throat can cause complications such as kidney inflammation and rheumatic fever. Rheumatic fever can lead to painful and inflamed joints, and a specific type of rash of heart valve damage. We also know that strep can cause pans pandas, which is a systemic infection, often causing problems with severe Ocd. And anxiety and affecting mostly young people. The research is unambiguous. According to the Cleveland clinic. Rheumatic fever is a rare complication of untreated strep, throat, or scarlet fever that most commonly affects children and teens, and in severe cases it can lead to serious health problems that can affect your child’s heart. Joints and organs. And research also shows that the rate of development of rheumatic fever in individuals with untreated strep infections is estimated to be 3%. The incidence of reoccurrence with a subsequent untreated infection is substantially greater. About 50% the rate of development is far lower in individuals who have received antibiotic treatment. And according to the World health organization, rheumatic heart disease results from the inflammation and scarring of the heart valves caused by rheumatic fever, and if rheumatic fever is not treated promptly, rheumatic heart disease may occur, and rheumatic heart disease weakens the valves between the chambers of the heart, and severe rheumatic heart disease can require heart surgery and result in death. The who states that rheumatic heart disease remains the leading cause of maternal cardiac complications during pregnancy. And additionally, according to the National Kidney foundation. After your child has either had throat or skin strep infection, they can develop post strep glomerial nephritis. The Strep bacteria travels to the kidneys and makes the filtering units of the kidneys inflamed, causing the kidneys to be able to unable or less able to fill and filter urine. This can develop one to 2 weeks after an untreated throat infection, or 3 to 4 weeks after an untreated skin infection. We need to find balance. And here’s what I want you to understand. Questioning the medical establishment and developing health literacy doesn’t mean rejecting all medical interventions. It means developing the wisdom to know when they’re necessary and lifesaving versus when they’re unnecessary and potentially harmful. When I see patients with confirmed lyme disease, serious strep infections or life. Threatening conditions like C diff. I don’t hesitate to recommend appropriate therapy but I also work to support their overall health address, root causes, protect and restore their gut microbiome and help them recover their natural resilience. The goal isn’t to avoid all medical interventions. It’s to use them wisely when truly needed, while simultaneously supporting your body’s inherent healing capacity and addressing the lifestyle factors that created the vulnerability. In the 1st place. All of this can be extremely overwhelming, and it can be frightening to understand or learn. But remember, the power that you have is knowledge. The more you learn about what’s actually happening in your health, in understanding nutrition. in learning what your body wants to be fed, and how it feels, and working with practitioners who are holistic in nature, natural, integrative, functional, whatever we want to call that these days. The more you can learn from them, the more control you have over your own health and what I would urge you to do is to teach your children what you’re learning. Teach them how to live a healthy lifestyle, teach them how to keep a clean environment. This is how we take back our own health. So thank you for joining me today on, let’s talk wellness. Now, if this episode resonated with you. Please share it with someone who could benefit from understanding how the Rockefeller medical system has shaped our approach to health, and how to reclaim your body’s wisdom while using medical care appropriately when truly needed. Remember, wellness isn’t just about feeling good. It’s about understanding your body, trusting its wisdom, supporting its natural healing capacity, and knowing when to seek appropriate medical intervention. If you’re ready to explore how functional medicine can help you develop this deeper health knowledge while addressing root causes rather than just managing symptoms. You can get more information from serenityhealthcarecenter.com, or reach out directly to us through our social media channels until next time. I’m Dr. Dab, reminding you that your body is your wisest teacher. Learn to listen, trust the process, use medical care wisely when needed, and take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode.The post Episode 250 -The Great Medical Deception first appeared on Let's Talk Wellness Now.

Reckless Training
Year-End Recap: Creatine HCL, Posing on Your Bad Side, Athlete Lifestyle Balance & Coaching Lessons

Reckless Training

Play Episode Listen Later Dec 15, 2025 63:42 Transcription Available


In this episode, we break down what this year truly taught us as athletes and coaches — the lessons that actually moved the needle in bodybuilding, powerlifting, and long-term physique development. We dive into the real truth about creatine HCL vs. creatine monohydrate, why some athletes benefit from switching, and how to use creatine effectively for strength, recovery, and muscle growth. We also get into posing breakthroughs, including the importance of practicing on your “bad side”, building symmetry, and fixing common mistakes we see in bikini and bodybuilding presentations. From there, we talk about the athlete lifestyle — managing real-life schedules, setting boundaries, learning to say no, and protecting your energy so you can actually train, recover, and perform at a high level. And finally, we share the biggest coaching lessons we learned this year, especially around communication. What helps athletes progress? What holds them back? What do we expect as coaches, and what can athletes do to get more out of the coach–athlete relationship? If you're an athlete in bodybuilding, powerlifting, StrongLifting, or simply someone trying to balance training with real life, this episode is packed with practical, experience-based insights to take into next season.

Independent Insights, a Health Mart Podcast
New Prescription Option for Fibromyalgia Treatment

Independent Insights, a Health Mart Podcast

Play Episode Listen Later Dec 15, 2025 45:40 Transcription Available


Patients with fibromyalgia have waited more than a decade for a new therapeutic option, and a recent regulatory approval signals a shift for these patients. This episode reviews the clinical trial data, mechanism of action, dosing considerations, and pharmacist‑relevant monitoring for the newly approved sublingual formulation of cyclobenzaprine HCl. You will gain practical insights to inform patient education, therapy optimization, and interdisciplinary collaboration in fibromyalgia care.HOSTRachel Maynard, PharmDGameChangers Podcast Host and Clinical Editor, CEimpactLead Editor, PyrlsGUESTAmanda (Mandy) Mullins, PharmD, BCPSClinical Pharmacist PractitionerVeterans AffairsPharmacists, REDEEM YOUR CPE HERE!CPE is available to Health Mart franchise members onlyTo learn more about Health Mart, click here: https://join.healthmart.com/CPE INFORMATIONLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe the mechanism of action and key clinical trial outcomes associated with the newly approved prescription medication for fibromyalgia.2. Identify pharmacist responsibilities for dosing, monitoring adverse effects, and patient counseling when supporting the use of this new fibromyalgia therapy.Rachel Maynard and Amanda (Mandy) Mullins have no relevant financial relationships with ineligible companies to disclose. 0.05 CEU/0.5 HrUAN: 0107-0000-25-371-H01-PInitial release date: 12/15/2025Expiration date: 12/15/2026Additional CPE details can be found here.

CEimpact Podcast
New Prescription Option for Fibromyalgia Treatment

CEimpact Podcast

Play Episode Listen Later Dec 15, 2025 45:44 Transcription Available


Patients with fibromyalgia have waited more than a decade for a new therapeutic option, and a recent regulatory approval signals a shift for these patients. This episode reviews the clinical trial data, mechanism of action, dosing considerations, and pharmacist‑relevant monitoring for the newly approved sublingual formulation of cyclobenzaprine HCl. You will gain practical insights to inform patient education, therapy optimization, and interdisciplinary collaboration in fibromyalgia care.HOSTRachel Maynard, PharmDGameChangers Podcast Host and Clinical Editor, CEimpactLead Editor, PyrlsGUESTAmanda (Mandy) Mullins, PharmD, BCPSClinical Pharmacist PractitionerVeterans AffairsPRACTICE RESOURCEPurchase this course to receive the exclusive downloadable practice resource handout to use as a reference guide to the podcastCPE REDEMPTIONThis course is accredited for continuing pharmacy education! Click the link below that applies to you to take the exam and evaluation:If you are already enrolled in this course, click here to redeem your credit. To purchase this episode and claim your CPE credit, click here. CPE INFORMATIONLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe the mechanism of action and key clinical trial outcomes associated with the newly approved prescription medication for fibromyalgia.2. Identify pharmacist responsibilities for dosing, monitoring adverse effects, and patient counseling when supporting the use of this new fibromyalgia therapy.Rachel Maynard and Amanda (Mandy) Mullins have no relevant financial relationships with ineligible companies to disclose.  0.05 CEU/0.5 HrUAN: 0107-0000-25-371-H01-PInitial release date: 12/15/2025Expiration date: 12/15/2026Additional CPE details can be found here.Follow CEimpact on Social Media:LinkedInInstagram

The Synthesis of Wellness
202. Intestinal Hyperpermeability & the Mucosal Barrier | Highlighting the Role of Zinc in Supporting Intestinal Barrier Function

The Synthesis of Wellness

Play Episode Listen Later Dec 5, 2025 12:45


In this encore episode, we highlight key roles that zinc plays in supporting various aspects of mucosal barrier integrity, while detailing the structure of the intestinal mucosal barrier. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium  3. The Mucus Layer  - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper  - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein  7. Factors Affecting Zinc Levels  - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption  - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters  9. Zinc's Role in the Intestinal Barrier  - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology   11. Zinc Carnosine  - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsor: 1. Shop ⁠O-Liv High Phenolic Extra Virgin Olive Oil⁠ and O-Liv's ⁠Olive Oil Supplement⁠. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Fuel for the Sole
120 | Nicotine Trends, Creatine and Caffeine, Ketone-IQ Bottles and More

Fuel for the Sole

Play Episode Listen Later Dec 2, 2025 31:20


This week on Fuel for the Sole, we break down Thomas' latest algorithm—one that's somehow convinced he (and everyone else) should be taking nicotine. We also dig into the trending supplement creatine, answering your top questions, including the best time to take it and the difference between creatine HCL and monohydrate. Plus, we cover the Tokyo Marathon's hydration rules and what runners need to know before race day.Want to be featured on the show? Email us (written or an audio file!) at⁠ fuelforthesolepodcast@gmail.com⁠. This episode is fueled by ASICS and RNWY!Head over to⁠ ASICS.com⁠ and sign up for a OneASICS account. It's completely free and when you sign up you will receive 10% off your first purchase. You also gain access to exclusive colorways on ASICS.com, free standard shipping, special birthday month discounts and more.Try the new Salty Carbs at https://rnwy.life/ and use code FEATHERS15 for 15% off your purchase. Disclaimer: This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

The Low Carb Athlete Podcast
Your Stomach Acid Is the Spark: Fix Fatigue, Bloating, Reflux & Hormone Chaos from the Inside Out

The Low Carb Athlete Podcast

Play Episode Listen Later Nov 30, 2025 35:07


Are you eating all the right foods, taking supplements, and still feeling tired, bloated, or stuck with stubborn weight? You might not have a food problem… you might have a digestion problem. In this episode of The Coach Debbie Potts Show, Debbie takes you deep inside the root cause of many "mystery" symptoms — low stomach acid (HCl) — and explains why this one simple imbalance can create a domino effect across your metabolism, hormones, energy, and brain. You'll learn: ✅ How stomach acid actually works — and why it's the spark plug for your entire digestive system ✅ The connection between low HCl, fatigue, hormone imbalance, thyroid function, and brain fog ✅ The weird clues your body gives you (like brittle nails, reflux, or even body odor) ✅ How HCl "unlocks" essential minerals like iron, zinc, and magnesium — and what happens when it doesn't ✅ Why PPIs and antacids can make things worse long-term ✅ The fascinating nitric oxide connection for gut health, motility, and LES tone ✅ How to safely restore your stomach acid, rebuild digestion, and reignite your metabolism ✅ The step-by-step FutureYou™ Rebuild Plan to move from metabolic chaos to metabolic harmony "Your stomach acid isn't the problem — it's the messenger. When you restore that first spark, everything downstream—your energy, hormones, and metabolism—starts working again." Topics Covered: 00:00 – Intro: Digestion as the missing link 04:30 – What stomach acid really does 08:00 – The mineral vault: how HCl unlocks nutrients 13:00 – Weird signs of low stomach acid 17:00 – PPIs, antacids & rebound reflux 22:00 – Nitric oxide and the vagus nerve 27:00 – The FutureYou™ Rebuild Plan 35:00 – Closing: How to test, not guess Resources Mentioned:

Software Lifecycle Stories
Numbers, Networks, and Nuance with Madhavan Jagannathan

Software Lifecycle Stories

Play Episode Listen Later Nov 28, 2025 37:46


Gayatri Kalyanaraman is in conversation with Madhavan Jagannathan (Maddy) , Instrument and Control Engineer by training, software technologist by experience, and financial explorer at heart. With over two decades of experience across HCL, Adobe, EMC, Dell, and VMware, Maddy brings together deep tech, systems thinking, and a passion for financial markets. Gayatri introduces Maddy, highlighting 17 years of friendship and his rare mix of humor, humility, and insight across hardware, software, and finance.02:00 – The Physics of Curiosity Maddy recalls his fascination with science, choosing physics for his undergraduate degree, and his early ambition to pursue research at IITs before pragmatically opting for instrumentation at Madras Institute of Technology.05:00 – The Unplanned Leap into Software A “lucky break” leads him into HCL Technologies, where a chance campus interview launches his career in software — landing him in the prestigious Cisco division during the early internet boom.08:00 – Early Memories of the Software World Maddy reflects on working at the intersection of hardware and network management — when internet access was rationed, innovation was exploding, and curiosity was rewarded.10:00 – Settling into the Tech Ecosystem He discusses how he initially longed for the process industry, only to realize that the software world offered greater opportunities, intellectual challenge, and balance — ultimately leading teams early in his career.13:00 – From HCL to Adobe: Finding the Power of Software Maddy shares how joining Adobe in Noida, during its early transition to SaaS, transformed his understanding of software's reach and power. “That one year at Adobe changed my view of what software could do.”16:00 – The EMC and Dell Era: Process Meets Innovation He moves from startups to EMC, where he embraces Six Sigma, process excellence, and later joins Dell, leading teams focused on data center innovation. “Dell was about process discipline and fast engineering — a perfect blend of structure and innovation.”20:00 – Clarifying ‘Process': From Chemistry to Systems Thinking Maddy reflects on how his training in process control and systems modeling shaped his understanding of software and organizational design.23:00 – Discovering Financial Markets His long-standing curiosity about stock markets takes root. From reading stock pages in newspapers to managing his first ESOPs, Maddy begins to explore investing and financial systems deeply. “It started with curiosity — how a single number next to a company name could tell a story.”26:00 – The Birth of a Trader Inspired by his MBA classes and a growing interest in quantitative methods, Maddy takes professional trading courses — blending math, technology, and market behavior. “Trading is where math, technology, and psychology collide.”29:00 – Lessons from the Trading Floor He shares insights from independent trading during COVID, emphasizing discipline, emotional control, and the realization that he's better suited for his own portfolio than managing others' money.32:00 – The Intersection of Tech and Finance Maddy discusses how his tech background enhances his understanding of market microstructures, algorithmic trading, and the growing influence of AI and quantum computing in finance.35:00 – The Philosophy of Continuous Exploration For Maddy, trading and technology are both lifelong explorations. “Markets teach you more than finance — they teach you patience, humility, and the ability to think statistically about your own life.”38:00 – Reflections on Career and Curiosity Gayatri and Maddy reflect on his multi-layered career: from a hardware engineer and software innovator to a financial thinker who continues to connect systems, people, and ideas. Key Themes:Evolving from hardware and instrumentation to deep software systemsThe interplay between process thinking and product innovationLifelong learning and curiosity as a career compassApplying software and systems logic to financial marketsEmotional intelligence and discipline in trading Memorable Quotes:“Trading is where math, technology, and psychology collide.”“That one year at Adobe changed my view of what software could do.”“Markets teach you more than finance — they teach you patience, humility, and the ability to think statistically about your own life.”“I didn't plan my career — I followed my curiosity, and that made all the difference.”https://www.linkedin.com/in/madhavan-jagannathan-559bb51/Madhavan “Maddy” Jagannadhan is a seasoned technologist and financial explorer whose career spans hardware engineering, software system leadership and independent investing. With early roots in instrumentation and network hardware, Maddy went on to lead development teams at industry names like HCL Technologies, Adobe Inc., EMC Corporation and Dell Technologies—designing software-driven systems and complex processes. Today, Maddy blends his systems thinking, curiosity and trading insight into mentoring, personal investing and bridging tech and financial markets. Madhavan has an engineering degree in Instrumentation and Control from MIT (Anna University) and an MBA degree from Great Lakes Institute of Management.

Metabolic Momma Secret's with Dylan Conrad
Berberine Mistakes For Insulin Resistance | Who Should & Shouldn't Take It

Metabolic Momma Secret's with Dylan Conrad

Play Episode Listen Later Nov 28, 2025 6:03


Berberine is one of the most popular supplements for improving insulin sensitivity and supporting fat loss — but many people are using it incorrectly, stacking it unnecessarily, or taking it when they don't actually need it.   In this episode, I break down:   • What insulin resistance really is and how it affects fat storage • How berberine works like nature's metformin to support blood sugar control • The correct berberine dosage and timing for best results • Berberine phytosome vs HCl (and why bioavailability matters) • The most common berberine mistakes I see with women • When berberine is helpful — and when it's unnecessary • How GLP-1 medications and HRT already increase insulin sensitivity • Why stacking berberine with GLP-1 or HRT can create diminishing returns • How supplement overlap slows progress and wastes money • The 4 supplement category framework (metabolic, foundational, hormonal, gut)   You'll also learn how sleep, walking, strength training, cortisol balance, and an anti-inflammatory diet naturally improve insulin sensitivity — and why personalized supplement plans always outperform generic advice.   This episode is for you if you're: ✔ Struggling with insulin resistance ✔ Using berberine for fat loss ✔ On GLP-1 medications ✔ On hormone replacement therapy ✔ Taking a large supplement stack ✔ Feeling unsure about supplement overlap  

The Synthesis of Wellness
200. Intestinal Mycobiome | Small Intestinal Fungal Overgrowth, Biofilms, and Intestinal Barrier Integrity

The Synthesis of Wellness

Play Episode Listen Later Nov 21, 2025 14:10


In this encore episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, impaired motility, diminished commensal bacterial populations, and weakened mucosal immunity.Topics: 1. Introduction- Focus on the gut mucosal barrier.- Emphasis on Small Intestinal Fungal Overgrowth (SIFO) and biofilms.2. Intestinal Barrier Anatomy- The mucosa: epithelium, lamina propria, and a thin band of smooth muscle.- The epithelial layer.- Covered by protective mucus composed of mucin glycoproteins secreted by goblet cells.- In the small intestine: less dense mucus.3. Epithelial Integrity- Tight junctions.- Paracellular barrier preventing uncontrolled antigen passage.4. Lamina Propria5. Overview of Small Intestinal Fungal Overgrowth (SIFO)- SIFO involves fungal overgrowth in the small intestine, commonly Candida species.- Small intestines: Low microbial density due to motility, gastric acid, bile acids, immune surveillance, and more.- Contributing factors: hypochlorhydria, impaired motility, reduced digestive enzymes, diminished competitive flora, lowered immunity, and more.6. Candida Pathogenicity- Candida exhibits phenotypic plasticity: yeast and hyphal forms.- Biofilm formation.7. Biofilm Formation- Biofilms are structured communities of microbes within a self-produced extracellular matrix.- Resistance to antimicrobials and immune defenses.- Can develop on intestinal mucosa and in various other regions.8. SIFO and SIBO Overlap- Root causes and overlap between SIFO and Small Intestinal Bacterial Overgrowth (SIBO).- Common symptoms.9. Gastric Acid in More Detail- Stomach epithelium includes mucous, parietal, chief, and enteroendocrine cells- Parietal cells secrete hydrochloric acid.- HCl denatures proteins and aids in inhibiting pathogens.- Hypochlorhydria: possible causes. 10. Downstream Effects of Low Acid11. Gut Motility in More Detail- Motility involves rhythmic smooth muscle contractions.- Enteric nervous system (ENS): myenteric and submucosal plexuses.- Dysautonomia and motility.12. SIFO Contributing Factors13. Candida Regulation- Candida in unicellular yeast form under homeostatic regulation.- Controlled by microbial competition, host defenses, antifungal peptides, and more.14. Role of Mucus and sIgA- Mucosal immunity and Candida populations.- Low sIgA levels.15. Conclusion- Mucosal barrier structure.- SIFO and Candida.- Biofilm formation, microbial persistence, and mucosal disruption.- SIFO and SIBO.- Multifactorial nature of fungal dysbiosis, types of biofilms, and small intestinal overgrowth.Thank you to our episode sponsor: 1. Shop O-Liv High Phenolic Extra Virgin Olive Oil and O-Liv's Olive Oil Supplement. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!Get Chloe's Book: "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok: @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Treating Blood Cancers
Hairy Cell Leukemia: Strategies for Improved Patient Outcomes

Treating Blood Cancers

Play Episode Listen Later Nov 20, 2025 40:10


Paul J. Hampel, MD, Mayo Clinic, Rochester, MN Recorded on November 4, 2025 Paul J. Hampel, MD Assistant Professor of Medicine Division of Hematology, Department of Medicine Mayo Clinic Rochester, MN In this episode, Dr. Paul Hampel from Mayo Clinic Rochester takes a comprehensive look at hairy cell leukemia (HCL). He reviews the current diagnostic work-up, including immunophenotypic and molecular testing, and highlights key clinical features that distinguish HCL from related disorders. Dr. Hampel also discusses approved frontline therapies and evidence-based approaches for relapsed or refractory disease, with attention to infection risk and supportive care. The conversation explores emerging agents, novel combinations, and clinical trials shaping the next wave of HCL management. Join us for this expert discussion, offering practical insights to enhance care and outcomes for patients with HCL.

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine
993 - 3-Step Protocol to Dissolve Gallstones Naturally

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine

Play Episode Listen Later Nov 17, 2025 27:52


Did you know your gut bacteria directly impact gallbladder function? Learn how your microbiome affects bile production, evidence-based supplements to support digestive health, and essential care tips after gallbladder removal. ✅Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/

Co-Movement Gym Podcast
Creatine: Performance, Recovery, Bone Health & Brain Power

Co-Movement Gym Podcast

Play Episode Listen Later Nov 10, 2025 42:18


Creatine has been in the spotlight for decades—but the newest research reaches far beyond the weight room. In this episode, Andrew covers: what creatine is, why it's so safe, how it fuels performance via ATP, and fresh findings on recovery, muscle growth, bone and fall risk, cognition and mood, sleep deprivation, and more. We also tackle who should consider supplementing, the best form (monohydrate vs HCl), and simple, effective dosing.The Co-Movement Gym Podcast is supported by Native Path Supplements and Lombardi Chiropractic.

Exam Room Nutrition: Nutrition Education for Health Professionals
133 | Creatine Isn't Just for Athletes: The Evidence for Brain, Bone, and Muscle Health

Exam Room Nutrition: Nutrition Education for Health Professionals

Play Episode Listen Later Nov 5, 2025 33:37


Creatine isn't just for athletes. In this episode, Dr. Scott Forbes joins Colleen Sloan, PA-C, RDN, to unpack the latest research on creatine safety, dosing, timing, and real-world use. Plus who should (and shouldn't) take it. This one supplement can support muscle, bone, and brain health and has over 600 clinical trials backing its safety. Too good to be true? Nope. That's creatine.Dr. Forbes shares the latest research, safety data, and practical recommendations for using creatine across the lifespan. You'll walk away knowing exactly what to recommend, how to dose it, and how to talk to your patients about it.In this episode, we cover:What creatine actually is and how it works in the bodyDietary vs. supplemental sources and why it's tough to get enough from food aloneMonohydrate vs. HCl vs. gummies: which forms are the bestCreatine + coffee: is combining them effective? Ideal timing, dosing, and how long it takes to see resultsClinical populations who may benefit mostWhat to do if creatinine is elevated on labsCommon myths about bloating, bulkiness, and safety in women and teensWhich brands to trust and how to spot third-party tested supplementsResources:Creapure Creatine supplementsConnect with Dr ForbesEpisode 72: Popular Diets and Supplement Science: Build Muscle, Lose Fat, and Stay FitAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week. Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer.

DekNet
Synology mientras tanto

DekNet

Play Episode Listen Later Oct 26, 2025 17:05


TECNOLOGIA y LIBERTAD--------------------------COMET: https://pplx.ai/dekkartwitter.com/D3kkaR Bitcoin BTC: dekkar$paystring.crypthttps://t.me/+0W_fPQXXOFAyNzE8

Proven Health Alternatives
Beyond the Gym: Creatine for Brain, Longevity and More

Proven Health Alternatives

Play Episode Listen Later Oct 24, 2025 34:10


In this episode, I sit down with Mark Faulkner to unpack the science behind creatine's two main forms: monohydrate and HCl. Mark reveals why creatine HCl stands out for its superior absorption and efficiency while clearing up common misconceptions that have limited its reputation to the gym. We explore how creatine fuels more than muscle growth. From immune support and cognitive enhancement to hormonal balance and cellular energy production, this conversation highlights its essential role in both performance and long-term health. Tune in to discover how creatine can become a cornerstone of your wellness strategy—one that helps both men and women move, think, and age better. Key Takeaways: Creatine hydrochloride offers improved solubility and absorption, requiring significantly smaller doses than creatine monohydrate to achieve similar effects. Beyond muscle building, creatine plays a crucial role in various bodily functions, including immune support, brain energy, and hormonal balance. Women, due to lower average muscle mass, may benefit significantly from creatine supplementation, particularly during hormonal transitions. Optimal dosing and timing for creatine can depend on individual goals; it can be effective when taken before exercise to boost energy and endurance. Creatine HCl's molecular efficiency supports cognitive function and overall health, making it not just an athlete's supplement but a vital nutritional aid for everyone. More About Mark Faulkner:   Mark Faulkner is the Founder and President of Vireo Systems and the inventor behind CON-CRĒT®, the #1 absorbed and most widely licensed creatine. With a passion for using science to help people live healthier, more active lives, Mark has founded multiple research-driven companies and holds nine patents. He began his career co-founding a forensic toxicology lab that developed the NFL's steroid testing program and worked with Olympic and NCAA athletes. In 2002, his mission to create safe, effective alternatives to steroids led to groundbreaking research on creatine hydrochloride (HCl), resulting in the creation of CON-CRĒT®—a superior, clinically backed form of creatine without the side effects of traditional products. Today, through Vireo Systems and its Promera Health division, Mark continues to advance innovation in nutraceuticals and biochemistry, delivering premium products for both people and pets. Website Instagram Connect with me! Website Instagram Facebook YouTube

Software Lifecycle Stories
Adapting to Innovation with George Mundassery

Software Lifecycle Stories

Play Episode Listen Later Oct 10, 2025 56:05


In this episode, Shiv is in conversation with George Mundassery, former SVP and Global head, AI and Automation with Tech Mahindra.George shares his extensive journey in the IT industry, starting from his early days with Tatas in power systems to his role in automation and AI implementation. George recounts his experiences working with various technologies, including mainframes, real-time systems, Fortran 77, C, and C++, and later transitioning to commercial applications and enterprise solutions with Tuxedo and WebLogic. He also discusses the challenges and successes in delivering large-scale applications, the importance of data management, and the critical role of customer engagement and team collaboration. Additionally, George offers valuable advice for aspiring IT professionals and those navigating mid-career challenges, emphasizing continuous learning, teamwork, and adapting to change.00:00 Introduction and Greetings00:10 Curiosity About Architects00:29 George's Origin Story01:12 Early Career in Power Systems02:44 Transition to Commercial Applications03:38 Exciting Journey with Middleware05:23 Experience with HCL and Startups07:13 Setting Up Automation and AI Units10:51 Challenges in Data Management15:49 Role as a CTO and Technology Adoption18:43 Importance of Non-Functional Aspects22:29 Handling Technical Risks in Projects28:05 Building a Strong Team from Scratch30:17 Balancing Technology, Customers, and Overheads33:22 Challenges and Successes in Automation and AI37:56 The Impact of Generative AI on Software Engineering46:29 Advice for IT Professionals at Different Career Stages53:17 Staying Grounded in a Fast-Paced Industry56:50 Conclusion and Final Thoughtshttps://www.linkedin.com/in/george-mundassery-2117533/George Mundassery is a seasoned IT leader with 40 years of global service delivery experience, recognized for his pioneering contributions in Intelligent automation and AI. He has served as Global Head of Automation and AI and held senior roles at major firms like Tech Mahindra representing the face of AI and automation initiatives. Throughout his career, he had been focused on building high-performing teams and establishing competencies to deliver value and outcome to global customers through Business and IT transformation programs.  George is acknowledged as a respected thought leader and member in leading organizations and think tanks, having shaped robust AI and Automation ecosystems and mentored cross-functional international teams.

Bikini Bites with Kyra Williams Fitness
How I Got Back on Track After Traveling (and How You Can Too)

Bikini Bites with Kyra Williams Fitness

Play Episode Listen Later Oct 2, 2025 19:52


Discover how to get back on track after travel with simple steps to reduce bloating, boost energy, and support digestion so you feel your best fast. Discover how to get back on track after travel with simple steps to reduce bloating, boost energy, and support digestion so you feel your best fast. HCL capsules - https://amzn.to/472vVIK Enzymes - https://amzn.to/42VsGjS Histamine supporting herbs - https://amzn.to/42X79r0 Histamine lotion - https://amzn.to/3Wg2flj

Sky House Herbs
Hair Loss & Thinning Solutions: Best Herbs & Practices For Hair Growth

Sky House Herbs

Play Episode Listen Later Sep 29, 2025 20:31


Hi friends, it's Ashley Marie Elenbaas. In this video, I open up about my own personal experiences with hair loss and thinning and share the natural solutions that have helped me along the way. Hair struggles can feel overwhelming, but there are many holistic approaches that support regrowth and long-term scalp health.We'll talk about some of the most common causes of hair loss, including stress, hormonal shifts, low iron, and nutritional deficiencies. I'll also share how daily practices like weekly scalp treatments, herbal teas, oils, and proper nutrition can make a big difference in supporting healthy, strong hair.

JJ Virgin Lifestyle Show
The Ultimate Creatine Guide for Women Over 40

JJ Virgin Lifestyle Show

Play Episode Listen Later Sep 21, 2025 28:08


Download my Ultimate Creatine Guide for Women before listening so you can read along and get the most out of the episode. You know that feeling when you discover something that completely changes your perspective on health? That's exactly what happened to me with creatine. For years, I avoided this supplement because of outdated misconceptions, but the research on creatine benefits for women over 40 has blown me away. Here's the reality: we actually need creatine MORE than men do, yet most of us are walking around severely deficient. We have less muscle mass to store creatine, we're not eating nearly enough animal protein to get adequate amounts from our diet, and we're dealing with unique stressors like hormonal fluctuations and sleep deprivation that drain our energy reserves even faster. When I finally tried the right form of creatine - and yes, the form matters tremendously - it was like flipping an energy switch I didn't even know existed. No more afternoon coffee crashes, better workouts, sharper mental focus, and for the first time in my life, I could travel internationally without jet lag. What you'll learn: Why women over 40 are walking around creatine-deficient - and how this impacts everything from your energy levels to your brain function The shocking difference between creatine monohydrate and creatine HCL - one causes bloating and GI issues in 76% of women, the other doesn't How to calculate your optimal creatine dosage based on your stress levels, workout intensity, and life demands (hint: it's way less than you think) The brain-boosting benefits beyond muscle building - from reducing depression when combined with SSRIs to helping with sleep deprivation and cognitive decline Why adding taurine and magnesium creates an amplification effect that makes your workouts more powerful and recovery faster Real-world success stories from women who've transformed their energy, athletic performance, and overall vitality The simple math that proves most women aren't getting enough creatine from diet alone - you'd need to eat a pound of raw meat daily Love the Podcast? Here's what to do: Make My Day & Share Your Thoughts! Subscribe to the podcast & leave me a review Text a screenshot to 813-565-2627 Expect a personal reply because your voice is so important to me. Join 55,000+ followers who make this podcast thrive. Want to listen to the show completely ad-free?  Go to subscribetojj.com Enjoy the VIP experience for just $4.99/month or $49.99/year (save 17%!) Click “TRY FREE” and start your ad-free journey today! Full show notes (including all links mentioned): https://jjvirgin.com/creatine40plus Learn more about your ad choices. Visit megaphone.fm/adchoices

The Synthesis of Wellness
198. Small Intestinal Bacterial Overgrowth & Hypochlorhydria | Low Stomach Acid, Intestinal Microbiome Dysbiosis, & a Brief Conversation on the Oral Microbiome

The Synthesis of Wellness

Play Episode Listen Later Sep 19, 2025 14:59


In this encore episode, we detail hypochlorhydria while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on possible influences of the oral microbiome and oral dysbiosis.Topics: 1. Introduction- Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth.- Discussion of intestinal microbiome and oral microbiome. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible symptoms of hypochlorhydria.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium.- H. pylori infection, autoimmunity, aging. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis- Oral and environmental microbes.- Altered gastric pH, bile, digestive enzymes, and more.- The oral cavity as the gateway to the GI tract.- Oral microbial species.- Oral hygiene and oral microbiome health. 10. Conclusion- Root-cause approach.Thank you to our episode sponsor: 1. ⁠⁠⁠⁠⁠⁠⁠⁠OmneDiem®'s⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠Histamine Digest®⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠Histamine Digest® PureMAX⁠⁠⁠⁠⁠⁠⁠⁠ : Use code STXAL9VI for 15% off.2. ⁠⁠⁠⁠⁠⁠⁠⁠Histamine Digest® Histamine Complete⁠⁠⁠⁠⁠⁠⁠⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Staying Connected
Rethinking Supplier Support - Effective Strategies for the Enterprise

Staying Connected

Play Episode Listen Later Sep 18, 2025 7:09


Against the backdrop of the ongoing struggle with the Verizon outsourcing to HCL, enterprise customers are being forced to rethink their supplier support models and partners.  In this 7-minute podcast, Theresa Knutson and Brent Knight from TC2 join Tony Mangino to discuss what customers can actually do to manage, escalate, and potentially fix support issues with their strategic network suppliers. If you would like to learn more about our experience in this space, please visit our Strategic Sourcing and Technology Consulting & Strategy Development Services webpages.

Over 40 Fitness Hacks
587: Mark Faulkner - Creatine Without the Bloat: Con-Cret's Founder on HCL vs. Monohydrate

Over 40 Fitness Hacks

Play Episode Listen Later Sep 17, 2025 28:54


Creatine Without the Bloat: Con-Cret's Founder on HCL vs. MonohydrateClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Mark Faulkner - Con-Cret SupplementsSocial Media: @concret_creatinewww.Con-Cret.comBrad opened by sharing your personal experience with creatine monohydrate — its benefits for strength and endurance, but also the downside of bloating and water retention that kept you from using it consistently. Mark clarified that “HCL” vs. “hcl” is just a marketing capitalization difference and explained that creatine hydrochloride (HCL) can offer the same benefits with fewer side effects due to its superior bioavailability.Mark shared his science-heavy background (physics, biochemistry, toxicology) and his experience co-founding a forensic toxicology lab. His team built the NFL's steroid testing program, which sparked his interest in safe, legal performance enhancers. After selling the lab, he partnered with sports medicine researchers to find steroid alternatives that could help athletes recover and maintain strength safely. This search led to creatine HCL, which showed strong results for strength, endurance, and recovery without the typical side effects of monohydrate.Bioavailability & Efficiency: Creatine HCL is more easily absorbed due to its chemical structure and compatibility with stomach acid (HCL), allowing smaller doses to deliver more creatine to muscle, brain, and immune cells.Side Effects: Princeton research shows over 50% of men and 75% of women experience bloating and GI distress with monohydrate, which is largely avoided with HCL.Performance Benefits: Faster recovery, increased training capacity, and leaner muscle gains compared to monohydrate.Mark emphasized that creatine supports all cells — not just muscles:Brain health & cognition: Supports energy for thinking and memory.Immune system: T-cells upregulate creatine receptors before attacking pathogens or abnormal cells (e.g., cancer), so adequate creatine helps them “win the fight.”Disease prevention & longevity: The CDC is investigating low creatine levels as a factor in rising chronic disease rates.Mark provided a three-tier approach:Daily Health: 750 mg per day for most people.Exercise / Biohacking: 750 mg per 100 lbs of body weight 30–60 minutes pre-workout (double up on very strenuous days).Medical/Disease States: Higher doses (up to 4–6 g daily) split into multiple servings.He also noted that creatine should be taken daily with no need to cycle off, and extra doses can help with fatigue, poor sleep, or jet lag.Mark stressed that over 90% of creatine is made in China, and quality can vary dramatically. Con-Cret is the only U.S.-made creatine, manufactured in an NSF-certified facility in Nebraska, ensuring purity and safety for athletes who undergo drug testing. Con-Cret holds multiple patents for its creatine HCL technology, further setting it apart.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

Staying Connected
Verizon's HCL Gamble

Staying Connected

Play Episode Listen Later Sep 9, 2025 9:04


It's been over two years now since Verizon and HCL announced their strategic partnership, which included Verizon retaining its sales function, solutioning, and customer acquisitions, and HCL taking over post-sale implementations and ongoing customer support.  In this 9-minute podcast, Theresa Knutson and Brent Knight from TC2 join Tony Mangino to discuss how the strategic partnership is impacting enterprise customers and if Verizon's HCL gamble is paying off. If you would like to learn more about our experience in this space, please visit our Strategic Sourcing and Technology Consulting & Strategy Development Services webpages. Follow us on LinkedIn: LB3 & TC2  

The Synthesis of Wellness
196. The Stomach, Gastric Acid, & Vitamin B12 | With a Brief Conversation on H. pylori

The Synthesis of Wellness

Play Episode Listen Later Sep 5, 2025 15:22


In this encore episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori  2. H. pylori Overview- Gram-negative bacterium, can colonize the stomach lining- Many individuals remain asymptomatic- Symptoms - Can contribute to gastritis and peptic ulcers- Produces urease, hydrolyzes urea into ammonia (NH₃) andcarbon dioxide (CO₂)- Ammonia neutralizes stomach acid locally, protective microenvironment- H. pylori damages the mucosal barrier and contributes to persistence- Possesses additional virulence factors 3. Gastric Anatomy  -  Stomach is divided into the cardia, fundus, body, and pylorus- The gastric mucosa - The epithelial lining; mucous cells, parietal cells, chief cells, and more 4. Mucous Cells and Mucosal Protection  - Line the gastric pits and secrete thick, viscous mucus- Mucus composed of water, mucin glycoproteins, and other low-molecular-weight molecules- Traps bicarbonate ions (HCO₃⁻)- Shields the stomach lining 5. Parietal Cells  - Located in the gastric glands, predominantly in the fundus and body- Secrete hydrochloric acid (HCl)- Secrete intrinsic factor (IF) 6. Vitamin B12 Overview - Cobalamin: DNA synthesis, red blood cell formation, neurological function, methylation, and more- Methylcobalamin and 5-deoxyadenosylcobalamin- Non-active forms include hydroxocobalamin and synthetic cyanocobalamin   7. Vitamin B12 Absorption Pathway  - B12 is released from proteins by HCl and pepsin- Binds first to haptocorrin- In the small intestine, pancreatic enzymes degrade haptocorrin- B12 binds intrinsic factor - Absorption in the ileum - Impairment  8. Chief Cells  - Located in the gastric glands- Secrete pepsinogen, activated by acid into pepsin- Also secrete gastric lipase 9. Hydrochloric Acid (HCl) - Secreted by parietal cells- Denatures dietary proteins and activates pepsinogen- Acts as a defense mechanism by aiding in sterilizing ingested food 10. Relevance of H. pylori - Produces urease that breaks down urea into NH₃ and CO₂- Ammonia neutralizes acid locally, forming a protective “bubble”- Enhances mucosal damage and microbial persistence 11. B12 Absorption  - Multiple factors and root causes can impair absorption- H. pylori 12. Hypochlorhydria  - Symptoms- Absorption: vitamin B12, iron, calcium, magnesium, more- Small Intestinal Bacterial Overgrowth (SIBO)  13. Conclusion- Multi-factorial, root cause approachThank you to our episode sponsor: 1. ⁠⁠⁠⁠⁠⁠OmneDiem®'s⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Histamine Digest®⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠Histamine Digest® PureMAX⁠⁠⁠⁠⁠⁠ : Use code STXAL9VI for 15% off.2. ⁠⁠⁠⁠⁠⁠Histamine Digest® Histamine Complete⁠⁠⁠⁠⁠⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Software Lifecycle Stories
Blending Roles, Breaking Ceilings with Shikha Munjal

Software Lifecycle Stories

Play Episode Listen Later Aug 29, 2025 42:52


In this episode of Software People Stories, Gayatri Kalyanaraman speaks with Shikha Munjal, Associate Director Fidelity International, about her dynamic journey across technology, finance, people management and community building.Shikha Munjal's story begins in a small town in Haryana, where she pursued computer science engineering—a choice influenced by her father's vision rather than her own. What started as a decision made for her soon turned into a lifelong passion for technology and problem-solving.She began her career with Accenture in Bangalore, diving straight into the corporate world just two days after finishing her final exams. Although trained in one technology, she was placed on projects with Informatica and data technologies, which opened a new career-long interest in data management and reporting tools.From there, Shikha moved to Headstrong (later acquired by Genpact), working primarily with Morgan Stanley's account, and even spent nearly a year onsite in Tokyo. That global experience left a lasting impression on her work ethic—she admired the Japanese culture of discipline, continuous learning, and deep focus.Her journey next took her to JP Morgan in Mumbai, where she strengthened her expertise in financial services and data-driven systems. But personal circumstances brought her back to the Delhi NCR region, where she eventually joined Fidelity International, her professional home for over a decade.At Fidelity, Shikha grew into senior leadership, taking on roles that blended technology, business analysis, and product management. She emphasized not just building solutions, but delivering real business outcomes—aligning technology with the fast-paced demands of the financial services industry.Along the way, she invested in continuous learning—pursuing certifications in Informatica, IBM, product management, financial analysis, and cloud/data platforms like Snowflake. She transitioned from being a technologist to a business leader and product owner, always guided by her growth mindset.Beyond her corporate role, Shikha has been an active advocate for diversity and inclusion, serving as a chapter lead at AnitaB.org North India. She blends her professional identity with her personal roles as a mother, wife, daughter, and sister, often saying that her strength comes from integrating all these parts of her life.Today, as Associate Director at Fidelity International, Shikha is shaping data strategies, product roadmaps, and inclusive leadership practices—all while staying curious, resilient, and adaptable in an era of rapid technological and business change.Quotable Moments from Shikha Munjal's Episode“The whole is greater than the sum of its parts – I've learned to blend my roles as a mother, daughter, professional, and leader.”“Comfort and growth do not coexist. The moment I feel my work is not challenging me, I know it's time to evolve.”“What keeps me going is not climbing the career ladder, but continuously adding to my profile and learning something new.”“If you enjoy the process of learning, the outcomes will follow naturally.”“In technology, every four to eight years your skills get challenged – you need to continuously upskill to stay relevant.”“I always believed that being connected to the business side meant being connected to the real world – solving real problems, not just writing code.”“We need to embrace uncertainty rather than rush to solve it. Sometimes dwelling on the ambiguity gives deeper insights.”“Data today is like a marketplace—you should be able to shop for it within an organization, but with the right entitlements and governance.”Shikha Munjal is Associate Director at Fidelity International with over 20 years of experience in technology and financial services. She has held roles at Accenture, HCL, Morgan Stanley, JP Morgan, and now Fidelity. A strong advocate for diversity and inclusion, she has led the North India chapter of AnitaB.org. Shikha is passionate about data, product management, and continuous learning, and believes in shaping her career with curiosity and resilience.Shikha can be reached at https://www.linkedin.com/in/shikha-munjal-19370113a/

The Synthesis of Wellness
193. The Intestinal Mucosal Barrier & Hyperpermeability | Highlighting the Role of Zinc in Supporting Intestinal Barrier Function

The Synthesis of Wellness

Play Episode Listen Later Aug 15, 2025 15:06


In this episode, we detail the structure and function of the intestinal mucosal barrier, highlighting key roles that zinc plays in supporting various aspects of mucosal barrier integrity. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium  3. The Mucus Layer  - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper  - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein  7. Factors Affecting Zinc Levels  - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption  - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters  9. Zinc's Role in the Intestinal Barrier  - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology   11. Zinc Carnosine  - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsors: 1. ⁠⁠⁠⁠OmneDiem®'s⁠⁠⁠⁠ ⁠⁠⁠⁠Histamine Digest®⁠⁠⁠⁠ and ⁠⁠⁠⁠Histamine Digest® PureMAX⁠⁠⁠⁠ : Use code STXAL9VI for 15% off.2. ⁠⁠⁠⁠Histamine Digest® Histamine Complete⁠⁠⁠⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.3. Codex Labs: Explore Codex Labs' collections for acne, eczema, and more. Shop the BIA Collection HereThanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Third Man Walking
Third Man Walking No. 118: The Right to Be Patient

Third Man Walking

Play Episode Listen Later Aug 6, 2025 35:34


Your correspondent plays a $5/$5/$10 session in which he wonders what to do facing a string bet, then navigates a long card-dead stretch. He also muses about the possibility of playing on stream. FORUM DISCUSSION: CLICK HERE 0:15 $5/$5/$10 session (with digressions)1:26 Limit hold-em vs. no-limit hold-em4:07 Weird string-bet spot: AJo (no clubs) on A95xccJxTccc10:19 KsQx on JT2sssAxKx13:00 Struggling with how to maximize winnings against tighter recreational players13:45 AxQd on 765dddQx8x16:17 JTss on T54dxd5x6x20:31 KK on J74rJhh9x22:12 KK (again) on T77ddxAxJddd26:11 9c9x on T53cxcQss5ccc28:15 The HCL controversy/challenge and thoughts on playing on stream33:49 KK on 443xcchttp://twitter.com/thirdwalkinghttp://crushlivepoker.com

The Synthesis of Wellness
190. IMO, SIBO Subtypes | Interactions Among Intestinal Methanogen Overgrowth (IMO), Hydrogen Sulfide-Dominant Small Intestinal Bacterial Overgrowth, and Hydrogen-Dominant SIBO

The Synthesis of Wellness

Play Episode Listen Later Aug 1, 2025 15:00


In this encore episode, we detail overlap among intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO  - Discussion of overlap  2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea  - Methane and intestinal transit- Bloating, abdominal discomfort, constipation  - Associated with irritable bowel syndrome with constipation (IBS-C)   3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms  - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating  - Different forms of SIBO can coexist  6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea    7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor  - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions  - Gastric acid, digestion and antimicrobial defense   9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release   10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation   11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract  - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption   12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions  - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility  - Intestinal motility and ENS function in microbial homeostasis  - Hydrogen sulfide as a gasotransmitterGet Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Healing Horses with Elisha
79: Glucosamine as a Joint Supplement for Horses: Too Good to be True?

Healing Horses with Elisha

Play Episode Listen Later Jul 29, 2025 22:16


We are exploring glucosamine today.About a decade ago, glucosamine was marketed and sold as a joint supplement for horses. It is still available for joint support in dogs and humans, but seldom as a supplement for horses. In this episode, I discuss my experience with glucosamine, sharing its origin and clarifying some of the holistic principles it breaks.Nutrients vs. NutraceuticalsNutrients are the vitamins, minerals, and essential fatty acids that are essential for life and must come from food. Glucosamine is a nutraceutical, a non-essential compound found naturally in cartilage that can help manage joint inflammation. It is not a dietary requirement, and it does not address deficiencies.Doubt Around GlucosamineGlucosamine was once widely used in equine joint supplements, often combined with MSM or chondroitin. However, many horse owners and practitioners saw no real benefits. Its popularity was due to marketing and general concerns about joint health and mobility in horses.Inflammation Supplements alone cannot cure joint inflammation. Often, underlying factors (stress, poor diet, and excessive sugar) play a role. If those issues go unaddressed, even the best supplements will be inneffective.Insulin-Resistant HorsesGlucosamine is an amino sugar that contains a glucose molecule, which raises red flags for insulin-resistant horses or those with a sluggish, congested liver. Those horses are already prone to inflammation and joint pain, and adding glucosamine may further burden their liver's ability to metabolize.Long-Term SupplementationLong-term use of glucosamine without addressing nutrient deficiencies may do more harm than good. The liver metabolizes everything that enters the body, so long-term supplementation could overburden it, especially if the supplement is unnecessary or of low quality.Source MattersMost glucosamine gets sourced from shellfish, which violates holistic principles for horses, as they are strict herbivores. Using animal-based ingredients for horses is not considered species-appropriate and should always be avoided unless the supplement is truly effective.Glucosamine Forms and Sulfur SensitivityGlucosamine comes in different forms- either glucosamine sulfate or glucosamine HCl. As the sulfate version can cause sensitivities, like hives or respiratory issues, glucosamine HCl may be a safer option for horses with sulfur sensitivity.Evaluating Supplement EffectivenessTo assess whether a supplement is truly helping, always consider whether mobility is improving and inflammation is decreasing. If you cannot see or measure any benefit, reconsider its use. Addressing nutrient deficiencies will likely lead to more effective and lasting results.Study Limitations Scientific studies on glucosamine are inconclusive and often based on other species (like rats, mice, or humans), so they may not reflect the realities of insulin-resistant or metabolically compromised horses. Ultimately, the individual history and response of the horse should guide your decisions.Final ConsiderationsAlthough glucosamine is not inherently harmful, its long-term use should be questioned, especially for horses with insulin resistance. Glucosamine is not an essential nutrient, and it may place unnecessary strain on the body. Always prioritize foundational nutrition before turning to nutraceuticals.Links and resources:Connect with Elisha Edwards on her website Join my

JJ Virgin Lifestyle Show
5 Bone Health Secrets Your DEXA Scan Won't Reveal

JJ Virgin Lifestyle Show

Play Episode Listen Later Jul 27, 2025 25:26


I'm about to share something that completely changed how I think about bone health – and it might shock you, too. For years, I've been getting DEXA scans and feeling confident about my bone health because my scores looked great. Then I discovered a revolutionary new test called REMS (radiofrequency echographic multi-spectrometry), and guess what? Despite my "perfect" DEXA results, I actually have mild osteopenia. This was my wake-up call, and it's why I'm passionate about sharing the complete truth about bone health supplements women over 40 need to know. Here's what no one tells you: traditional DEXA scans only measure bone mineral density – how much bone you have – but they miss the crucial piece of bone quality. You could have normal bone density but still have fragile bones if your bone architecture, turnover rates, and collagen integrity aren't optimal. That's why I'm diving deep into the cutting-edge strategies that go far beyond calcium supplements, including specific exercises that load your spine and hips, the power of creatine for postmenopausal women, and why a simple weighted vest might be one of the best investments you'll ever make for your future self. What you'll learn: Why waiting until 65 for your first bone density test is setting you up for failure (and when you should really start testing) The game-changing difference between bone mineral density and bone quality – and why you need both for truly strong bones How REMS testing provides a radiation-free, real-time assessment that's revolutionizing personalized aging care The specific exercises that create the bone-building stress your skeleton craves, including the magic of weighted vest walking Why bone health supplements women over 40 should include creatine HCL and how it works synergistically with resistance training The hidden risk factors stealing your bone strength (hint: it's not just menopause) My complete protocol for women 40+ to build and maintain strong bones from the inside out How to overcome anabolic resistance as you age and why protein timing matters more than you think Love the Podcast? Here's what to do: Make My Day & Share Your Thoughts! Subscribe to the podcast & leave me a review Text a screenshot to 813-565-2627 Expect a personal reply because your voice is so important to me. Join 55,000+ followers who make this podcast thrive. Want to listen to the show completely ad-free?  Go to subscribetojj.com Enjoy the VIP experience for just $4.99/month or $49.99/year (save 17%!) Click “TRY FREE” and start your ad-free journey today! Full show notes (including all links mentioned): https://jjvirgin.com/bonehealth Learn more about your ad choices. Visit megaphone.fm/adchoices

Save My Thyroid
Still Struggling After a Graves or Hashimoto's Diagnosis? Watch This (SMT Audit)

Save My Thyroid

Play Episode Listen Later Jul 22, 2025 31:55


Her antibodies were high, her gut was off and surgery was on the table. So she started asking what was really driving her symptoms.Alexandria was told she had the antibodies for both Graves' and Hashimoto's in 2017 and initially followed conventional advice, including methimazole. But after facing the possibility of thyroid removal, she explores deeper root causes. This health audit traces the progress she's made with dietary changes, gut support, and lifestyle shifts and the imminent questions as she prepares for a future pregnancy. We discuss why her antibody levels dropped, where she's still seeing symptoms, and what steps might help her move forward without fully relying on medication.Managing your thyroid but curious about alternative support options? Listen to this episode!Episode Timeline: 00:00 – Episode Overview01:44 – Podcast Intro02:16 – Meet Alexa and her Diagnosis 03:00 – Seeking Alternatives to Thyroid Removal04:42 – Impact of gluten-free and AIP diets06:00 – Goiter changes with diet06:44 – Dairy and food tradeoffs07:14 – Antibody testing history08:03 – Gut support: HCl, Rifaximin, colostrum09:18 – SIBO diagnosis and food sensitivities10:42 – Gluten, permeability, and testing limitations11:33 – Lifelong gut issues and acid blocker use13:23 – Apple cider vinegar and digestive strategies15:19 – Pregnancy while on medication16:00 – Detox planning before conception18:32 – Stool test, travel, and GI infections19:19 – SIBO, food poisoning, and motility damage22:16 – AIP next steps and testing decisions23:52 – Podcast Outro24:13 – Final Thoughts and RecommendationsFree resources for your thyroid healthGet your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.comHigh-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' s Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid?Click Here  to access hundreds of free articles and blog posts.Click Here for Dr. Eric's YouTube channelClick Here to join Dr. Eric's Graves' disease and Hashimoto's groupClick Here to take the Thyroid Saving Score Quiz Do You Want Help Saving Your Thyroid? Click Here to access hundreds of free articles and blog posts. Click Here for Dr. Eric's YouTube channel Click Here to join Dr. Eric's Graves' disease and Hashimoto's group Click Here to take the Thyroid Saving Score Quiz Click Here to get all of Dr. Eric's published booksClick Here to work with Dr. Eric

The Synthesis of Wellness
188. The Stomach | Symptoms of H. pylori & Hypochlorhydria, and a Conversation on the Effects of Low Stomach Acid on Micronutrient Absorption

The Synthesis of Wellness

Play Episode Listen Later Jul 18, 2025 14:47


In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in conditions such as small intestinal bacterial overgrowth (SIBO).Topics:1. Hypochlorhydria - Low stomach acid.- Aging, autoimmune gastritis, chronic PPI use, H. pylori infection.2. H. pylori - Common gram-negative bacterium that colonizes the stomach lining.- Symptoms.- Produces urease.- Ammonia neutralizes acid, creating a protective microenvironment.- Additional virulence factors and ability to form biofilms contribute to persistence.3. Gastric Anatomy & Layers- The stomach: hollow, muscular organ for mechanical and chemical digestion.- Regions: Cardia, fundus, body, and pylorus.- Layers: Mucosa, Submucosa, Muscularis externa, Serosa4. Mucosal Layer - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.- Gastric pits lead to gastric glands, which contain specialized secretory cells.5. Specialized Gastric Cells- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.- Intrinsic factor and vitamin B12 absorption.6. Vitamin B12 Absorption- Essential for DNA synthesis, RBC formation, neurological function.- Released from food proteins by gastric acid and pepsin.- Impaired absorption.7. Role of Gastric Acid in Broader Micronutrient Absorption- Absorption of minerals.- Soluble, ionized state.- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.8. Protective Role of Gastric Acid- Acts as a line of defense against ingested pathogens.- Maintains low microbial diversity in the stomach.- Low HCl and SIBO (Small Intestinal Bacterial Overgrowth).9. Symptoms of Low Stomach Acid- Bloating, early satiety, excessive belching.- Undigested food in stool, chronic constipation.- May reflect impaired enzymatic activation and digestive insufficiency.10. Conclusion- Multifactorial causes and downstream effects.- Optimal range of stomach acid: neither high nor low.Thank you to our episode sponsor: 1. ⁠OmneDiem®'s⁠ ⁠Histamine Digest®⁠ and ⁠Histamine Digest® PureMAX⁠ 2. ⁠Histamine Digest® Histamine Complete⁠ with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

The Synthesis of Wellness
187. Intestinal Mycobiome | Small Intestinal Fungal Overgrowth, Biofilm Formation & Microbial Persistence, and Intestinal Barrier Integrity

The Synthesis of Wellness

Play Episode Listen Later Jul 11, 2025 14:52


In this episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, reduced pancreatic enzyme and bile output, impaired motility, diminished commensal bacterial populations, and weakened mucosal immunity.Topics: 1. Introduction- Focus on the gut mucosal barrier.- Emphasis on Small Intestinal Fungal Overgrowth (SIFO) and biofilms.2. Intestinal Barrier Anatomy- The mucosa: epithelium, lamina propria, and a thin band of smooth muscle.- The epithelial layer.- Covered by protective mucus composed of mucin glycoproteins secreted by goblet cells.- In the small intestine: less dense mucus.3. Epithelial Integrity- Tight junctions.- Paracellular barrier preventing uncontrolled antigen passage.4. Lamina Propria5. Overview of Small Intestinal Fungal Overgrowth (SIFO)- SIFO involves fungal overgrowth in the small intestine, commonly Candida species.- Small intestines: Low microbial density due to motility, gastric acid, bile acids, immune surveillance, and more.- Contributing factors: hypochlorhydria, impaired motility, reduced digestive enzymes, diminished competitive flora, lowered immunity, and more.6. Candida Pathogenicity- Candida exhibits phenotypic plasticity: yeast and hyphal forms.- Biofilm formation.7. Biofilm Formation- Biofilms are structured communities of microbes within a self-produced extracellular matrix.- Resistance to antimicrobials and immune defenses.- Can develop on intestinal mucosa and in various other regions.8. SIFO and SIBO Overlap- Root causes and overlap between SIFO and Small Intestinal Bacterial Overgrowth (SIBO).- Common symptoms.9. Gastric Acid in More Detail- Stomach epithelium includes mucous, parietal, chief, and enteroendocrine cells- Parietal cells secrete hydrochloric acid.- HCl denatures proteins and aids in inhibiting pathogens.- Hypochlorhydria: possible causes. 10. Downstream Effects of Low Acid11. Gut Motility in More Detail- Motility involves rhythmic smooth muscle contractions.- Enteric nervous system (ENS): myenteric and submucosal plexuses.- Dysautonomia and motility.12. SIFO Contributing Factors13. Candida Regulation- Candida generally remains in unicellular yeast form under homeostatic regulation.- Controlled by microbial competition, host defenses, antifungal peptides, and more.14. Role of Mucus and sIgA- Mucosal immunity (including sIgA) aids in regulating Candida populations.- Low sIgA levels (due to stress, immune suppression, dysbiosis,…) weaken defense 15. Conclusion- Mucosal barrier structure.- SIFO and Candida.- Biofilm formation, microbial persistence, and mucosal disruption.- SIFO and SIBO.- Multifactorial nature of fungal dysbiosis, types of biofilms, and small intestinal overgrowth.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

The Human Upgrade with Dave Asprey
Why I Add Creatine to My Coffee Every Morning (And You Should Too) : 1298

The Human Upgrade with Dave Asprey

Play Episode Listen Later Jul 3, 2025 30:41


Creatine isn't just for bodybuilders. It's one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization. You'll learn how to harness creatine for everything from mental performance and mood regulation to faster recovery and better metabolism. Dave covers creatine dosage and timing, how to use creatine loading versus maintenance protocols, and how to enhance creatine absorption by mixing it with hot water or pairing it with glucose and protein to leverage insulin-sensitive pathways. He also shares next-level stacking strategies by combining creatine with caffeine (including Danger Coffee), beta-alanine, nitrates, and electrolytes to maximize both mental and physical results. Whether you're using creatine for brain energy, sprint power, cold therapy performance, or cognitive resilience, this episode delivers practical tools you won't hear anywhere else. If you're following a carnivore diet, in ketosis, experimenting with fasting, or just want to feel sharper and more energized, creatine fits right in. Dave also explores cutting-edge options like GAA creatine, creatine HCL, and intranasal delivery systems, along with key nutrient pairings like TMG and folinic acid to support methylation and avoid side effects. Plus, he explains why vegetarians and vegans may need creatine the most. This is your complete guide to creatine brain benefits, mitochondrial support, memory enhancement, and smarter not harder living. You'll Learn: • How creatine supports neuroplasticity, brain energy, and cognitive function • Why mitochondrial health is the key to memory, mood, and mental performance • The real science behind creatine dosage, absorption, and stacking strategies • How creatine fits into ketosis, fasting, and a carnivore lifestyle • Why vegans and vegetarians may suffer from creatine deficiency • How to combine creatine with caffeine, nitrates, and nootropics for peak performance • Ways to biohack your metabolism, muscle growth, and mental clarity • The link between creatine, sleep optimization, and reduced brain fog • How creatine protects against oxidative stress and supports longevity • What you need to know about GAA creatine, methylation support, and delivery mechanisms Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Calroy | Head to https://calroy.com/dave for an exclusive discount. - BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Resources: • Danger Coffee: https://dangercoffee.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:14 Creatine for Overall Health and Longevity • 06:10 Addressing Common Myths About Creatine • 08:55 How to Use Creatine Effectively • 19:58 Special Use Cases and Recommendations • 24:58 Choosing the Right Creatine • 28:41 Conclusion and Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Two by Two
GCCs vs Indian IT companies

Two by Two

Play Episode Listen Later Jul 3, 2025 79:26


Microsoft, Amazon, Google, GS, JP Morgan Chase, Deloitte, Walmart, Bosch, Adobe, Target, Salesforce, AstraZeneca.What's common to these dozen organisations? Other than the fact that they are, well, large, well-respected and innovative?They all operate their own development and innovation centres in India. Often sprawling campuses and offices across multiple cities, filled with Indian engineers, project managers, product experts, designers, HR, finance and, well, virtually every function that's required to run a business.They're called GCCs. Global Capability Centres.There are over 1,000 global organisations that collectively operate over 1,700 GCCs across India. They employ over 2 million professionals. They generate over $40 billion in annual value, set to surpass $100 billion in another five years.So, what's the problem?Well, most GCCs are technically doing work that could have been outsourced to Indian outsourcers like Infosys, TCS, Wipro, HCL, etc. In fact, GCCs are so successful a strategy that they're growing much faster than Indian outsourcers.And as if taking away potential revenue from Indian outsourcers weren't enough, GCCs are now also taking away talent. That's right. They're hiring experienced and talented professionals using higher salaries, better brands and the promise of better work.It appears to be a zero-sum game. A pie that isn't growing.Both our guests for today's episode are experts on GCCs, and they had a lot to say about the same. Our first guest is Narayana Ramamurthy, whom you'll hear us address as ‘Naru' throughout the discussion. Naru is the founder and CEO of Workfutr, a company which enables US and European organisations to harness India's offshore capability in technology, operations, and transformation. And our second guest is Karthik Padmanabhan, who is the managing partner for GCCs at Zinnow, a global management and consulting firm founded in 2002 that partners and advises global enterprises, outsourcers, PE firms around AI, automation, outsourcing and well, GCCs.Welcome to episode 49 of Two by Two.-Additional reading:ANSR's Ahuja duo on why “everybody, from Victoria's Secret to Google, will do pretty much the same thing in India” - https://the-ken.com/story/ansrs-ahuja-duo-on-why-everybody-from-victorias-secret-to-google-will-do-pretty-much-the-same-thing-in-india/GCCs could pose a potential threat to Indian IT - https://analyticsindiamag.com/gcc/gccs-could-pose-a-potential-threat-to-indian-it/-This episode of Two by Two was produced by Hari Krishna. Rajiv CN, our resident sound engineer, mixed and mastered this episode.If you liked this episode of Two by Two, please share it with your friends and family who would be interested in listening to the episode. And if you have more thoughts on the discussion, we'd love to hear your arguments as well. You can write to us at twobytwo@the-ken.com.

JJ Virgin Lifestyle Show
The Ultimate Creatine Guide for Midlife Energy and Focus

JJ Virgin Lifestyle Show

Play Episode Listen Later Jun 22, 2025 18:36


I'm breaking down everything you need to know about creatine - the game-changing supplement that's not just for bodybuilders anymore. As women over 40, we're dealing with changing metabolism, declining muscle mass, and energy dips that can make us feel like we're fighting an uphill battle. But here's what I've discovered: creatine isn't just about gym performance. It's your cellular battery booster that can sharpen your brain when you're sleep-deprived, help you recover faster from workouts, and even ease jet lag struggles. I'm sharing why I wish I'd started taking it decades ago, the crucial difference between creatine HCL and monohydrate (hint: one causes bloating, the other doesn't), and exactly how to dose it for maximum benefits without the side effects. Plus, I'm revealing my personal protocol for high-stress days, travel, and those nights when sleep just doesn't happen - because let's be real, life after 40 throws us curveballs and we need our energy to keep up.   What you'll learn: Why creatine is crucial for women over 40 and how it functions as your cellular battery booster The significant difference between creatine HCL and monohydrate forms and why absorption rates matter Proper dosing protocols for foundational use, intense workouts, and high-stress situations How creatine benefits brain function, focus, and mood - especially during sleep deprivation What to expect when starting creatine and how to monitor your progress with body composition Why creatine can help with jet lag, time zone adjustments, and travel recovery The connection between creatine and muscle definition, plus why slight weight gain is actually beneficial How to use creatine strategically for better workout performance and faster recovery Love the Podcast? Here's what to do: Make My Day & Share Your Thoughts! Subscribe to the podcast & leave me a review Text a screenshot to 813-565-2627 Expect a personal reply because your voice is so important to me. Join 55,000+ followers who make this podcast thrive. Want to listen to the show completely ad-free?  Go to subscribetojj.com Enjoy the VIP experience for just $4.99/month or $49.99/year (save 17%!) Click “TRY FREE” and start your ad-free journey today! Full show notes (including all links mentioned): https://jjvirgin.com/ultimatecreatineguide Learn more about your ad choices. Visit megaphone.fm/adchoices

The Synthesis of Wellness
184. Hypochlorhydria & Small Intestinal Bacterial Overgrowth | Low Stomach Acid, Microbial Dysbiosis, & a Brief Conversation on the Oral Microbiome

The Synthesis of Wellness

Play Episode Listen Later Jun 20, 2025 12:54


In this encore episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis.Topics: 1. Introduction- Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth.- Discussion of intestinal microbiome and oral microbiome. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible symptoms of hypochlorhydria.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium.- H. pylori infection, autoimmunity, aging. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis- Oral and environmental microbes.- Altered gastric pH, bile, digestive enzymes, and more.- The oral cavity as the gateway to the GI tract.- Oral microbial species.- Oral hygiene and oral microbiome health. 10. Conclusion- Root-cause approach.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

I Don't Care with Kevin Stevenson
Healthcare Operations Improve with AI That Unites Data, Automation, and Ethics

I Don't Care with Kevin Stevenson

Play Episode Listen Later Jun 18, 2025 30:38


Generative AI has captured the public imagination, but its most transformative use cases may lie far from flashy consumer tools. In healthcare operations, where complexity, inefficiency, and fragmentation remain persistent challenges, AI is now driving measurable improvements. Research suggests AI-enabled healthcare systems could cut administrative costs by up to $360 billion in the U.S. alone.So, how can health systems move beyond experimentation and adopt AI in ways that deliver real operational value?In this episode of I Don't Care, host Kevin Stevenson welcomes Quentin Fisher, founder of Aidan Systems, for a grounded and insightful conversation on AI's practical impact on healthcare operations. Fisher explains how AI-driven analytics, process automation, and predictive models are helping community health centers and midsized systems simplify workflows, reduce reporting burdens, and make more informed decisions.Key Takeaways from the Episode:Evolution of Healthcare AI – Healthcare AI's evolution has moved from rule-based systems to predictive models powered by organizational data and cloud computing.Strategic AI Adoption in Health Systems – Aidan's “AI Fit Assessment” helps health systems identify low-risk, high-value AI use cases to improve productivity and care delivery.Responsible and Ethical AI Use: Ethical AI deployment depends on the use case, data governance, and constant retraining to prevent model degradation and bias.Quentin Fisher is a seasoned technology leader and founder of AIDAN Systems, where he leverages AI and machine learning to streamline business operations and reduce inefficiencies, particularly in healthcare and manufacturing. With over two decades of experience, including senior roles at HCL and CSC, he has led global analytics initiatives across industries such as aerospace, automotive, and public sector, focusing on strategy, solution development, and partner enablement. His core expertise includes generative AI, global strategy, data science, and delivering enterprise AI platforms that prioritize real-world business outcomes.

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine
970 - Gut Health Tips From 7 Leading Experts (IBS, SIBO, Candida & Leaky Gut)

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine

Play Episode Listen Later Jun 9, 2025 47:00


In today's episode, 7 leading gut health experts share their most powerful and surprising treatment approaches to some of the most stubborn gut conditions - IBS, c.diff, SIBO, candida and leaky gut. All of them agree on one thing - antibiotics aren't the only solution to healing your gut. Watch now!   Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

Optimal Health For Busy Entrepreneurs
273. Chris Burres on the Hidden Nobel Prize-winning Molecule That Helps Your Cells Recover and Healthy Aging

Optimal Health For Busy Entrepreneurs

Play Episode Listen Later May 16, 2025 74:02


Chris Burres is a scientist, entrepreneur, and co-founder of MyVitalC, best known for bringing ESS60—a purified form of Carbon 60—to the health and wellness world. In this episode, Chris shares how this NASA-researched and Nobel Prize-winning longevity molecule is making waves in the worlds of biohacking, recovery, and cellular health.We dive into the science behind ESS60, how it supports your cells in managing oxidative stress, and what it means for energy, sleep, inflammation, and healthy aging. Chris also opens up about his surprising path to entrepreneurship, the value gleaned from improv comedy, and why optimizing your health is as much about consistency as innovation.This episode is a must-listen if you're interested in cutting-edge wellness, performance, and the truth about supplements.What You'll Learn in This Episode:What ESS60 is and how it differs from regular C60Why NASA and scientists were originally interested in this moleculeHow it works at the mitochondrial level to buffer oxidative stressReal-world benefits users report, from sleep to energy to inflammation supportChris's entrepreneurial journey and improv backgroundThe critical importance of protein as you age— Episode Chapter Big Ideas (timing may not be exact) —00:00 – Introduction00:53 – How Chris Burres got into improv and what it taught him about life & communication07:08 – What is ESS60 and how did Chris discover it?14:00 – The difference between C60 and ESS60 (and the supplement industry's quality problem)20:36 – Antioxidant mechanism explained: The BOSS Theory28:24 – Can ESS60 help with inflammation and oxidative stress?34:45 – The FDA, claims, and why language matters in supplements37:49 – Alcohol, hangovers, and “party recovery”39:27 – What it was like writing a book with a 2x NYT #1 bestselling author43:16 – Chris's current biohacking experiments: peptides, HCL, MOTC49:20 – Ultra-endurance athletes using MyVitalC to recover55:02 – Chris's views on diet, protein, and aging58:42 – Longevity, muscle retention, and avoiding the “standard American diet”1:02:57 – What success really means to Chris1:10:25 – Where to find Chris Burres and his special offer— Key Quotes from Chris Burres — "Success is boring. It's doing the same small things over and over until they add up to something great.”"I never thought a molecule used in batteries and tires would end up helping people sleep better and live longer.”"Your only job in improv—and in life—is to make the other person look brilliant."— Connect With Chris Burres —Website (and Get $15 off): https://www.myvitalc.com/ehl/Live Longer and Better book: https://www.amazon.com/Live-Longer-Better-Journey-Achievable/dp/B0CFCPVVH3Live Longer and Better (signed book copy & part of proceeds go to Operation Underground Railroad): http://www.livelongerandbetterbook.com/ Podcast (Live Beyond The Norms): http://www.livebeyondthenorms.com/ Instagram: http://instagram.com/myvitalc YouTube: https://www.youtube.com/@MyVitalC/videos — Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/Ready to take your health, leadership, and performance to the next level? Book a complimentary private executive health diagnostic call with Julian Hayes II. Link below. https://calendly.com/julian-exechealth/chemistryWebsite — https://www.executivehealth.io/***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner.

PokerNews Podcast
Poker Cheat DQ'ed from Tournament, Tom Dwan Update & Hawk Tuah Girl Returns

PokerNews Podcast

Play Episode Listen Later May 8, 2025 46:30


In the 890th episode of the PokerNews Podcast, Chad Holloway, Mike Holtz, and Kyna England talk about admitted poker cheat Ali Imsirovic being DQ'ed mid-tournament from an event in Florida. Was it the right thing to do? It was a highly debated development, and the crew dove headfirst into the drama by discussing a poker black list, what bestbet Jacksonville could've done differently, and if poker pariahs could even be welcomed back to the game. They then give an update on Tom Dwan, whose recent social media posts really concerned the poker community, and then Connor Richards headed to PokerGO Studio to chat with the controversial Haliey “Hawk Tuah Girl” Welch and others at the Celebrity Poker Tour (CPT) Game Night VI. From there, it's highlights from the Hustler Casino Live (HCL) Million Dollar Game III, such as old-school player Erick Lindgren satelliting his way in, Texas Mike's wild ride, and an interview with Steve! Oh, and we'd be remiss if we didn't talk about that epic hand between Alan Keating and Peter.  Mike then talks about making a final table at the Venetian and playing with Batman at a recent Charity Series of Poker (CSOP) event, Brad Gafford and John Juanda both won tournaments, and poker media veteran Paul Oresteen talks about his new Substack, which you can subscribe to here. Finally, PokerStars North America has introduced a dozen new "Throwables" and the PokerNews Podcast crew not only shares their favorites, but they also offer fans of the show an opportunity to win some just by either listening to or watching the podcast. The podcast is sponsored by the #1 free-to-play WSOP app. Remember to use the bonus code "POKERNEWS" if you download and play for an extra 1,000,000 in chips! A new PokerNews Podcast will drop weekly every Thursday at 8a PT / 11a ET / 4p UK time. Remember to subscribe to our YouTube channel so you do not miss an episode! Time Stamps *Time | Topic* 00:21 | Welcome Kyna England & Mike Holtz 01:01 | Admitted poker cheat Ali Imisorvic DQ'ed from poker tournament 02:47 | Second time this has happened 03:28 | Should poker have a black list? 09:11 | Is there a gray area when it comes to cheating in poker? 14:01 | Is Ali Imsirovic being made an example of? 15:56 | Update on Tom Dwan 19:10 | Haliey “Hawk Tuah Girl” Welch plays Celebrity Poker Tour event 20:38 | Highlights from CPT Game Night VI 22:31 | Sponsor: WSOP Free-to-Play App 23:00 | Hustler Casino Live (HCL) Million Dollar Game III 23:15 | Erick Lindgren wins satellite into MDG 25:40 | Texas Mike's up-and-down ride 27:00 | Steve & Tom Goldstein 27:21 | Interview w/ Steve at HCL 29:57 | Alan Keating & Peter battle it out 30:33 | Peter picks off Keating's bluff 32:27 | Alan Keating big winner with $1.9 million 33:41 | Biggest winners from all three Million Dollar Games 34:08 | Sponsor – WPT Global 34:40 | Mike makes final table at Venetian 36:15 | Mike & Batman play CSOP event supporting Critical Care Comics 37:20 | Matt Savage wins CSOP title 37:34 | George Wolfe wins RunGood Jacksonville Main Event for $92,817 37:45 | Brad Gafford Wins MSPT Season 16 Sycuan Main Event 39:20 | Graham Keith takes down PokerNews Championship at Malta Poker Festival 39:40 | John Juanda Wins Second Tournament of 2025 at APT Taipei 41:11 | New Substacks on the Block – Paul Oresteen 42:26 | PokerStars introduces new Throwables 43:57 | Win a PokerStars Throwable by listening to the PokerNews Podcast

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine
965 - Top 7 Supplements To Boost Your Digestion & Gut Health

Dr. Ruscio Radio: Health, Nutrition and Functional Medicine

Play Episode Listen Later May 5, 2025 40:58


Your digestion and gut health can benefit tremendously from using these 7 supplements! In this compilation, I'll go over the best and most appropriate use of each supplement, recommend protocols and breakdown each one's health benefits. Listen now!  Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

Realfoodology
Fix Your Digestion: Solutions for Bloating, Gas, + Gut Health | BIOptimizers

Realfoodology

Play Episode Listen Later Apr 29, 2025 65:52


246: If you're dealing with gas, bloating, heartburn, constipation, or diarrhea, you're going to want to hear this conversation. I'm joined by Wade Lightheart, co-founder of BiOptimizers, to dive into real, actionable strategies you can start using today to optimize your digestion and feel better fast. We break down how digestive challenges can impact not just your gut, but also your brain function and overall quality of life through the gut-brain connection. I also share my own story of struggling with severe heartburn in college—and how addressing digestion can make a huge difference beyond just symptom relief. Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Topics Discussed:  How can I naturally improve digestion and reduce symptoms like gas, bloating, and heartburn? What role do digestive enzymes and supplements play in gut health? How are digestion issues connected to brain fog and cognitive problems? What are the best ways to heal an inflamed gut and support overall digestive function? How do you choose high-quality digestive health supplements that actually work? Timestamps:  00:00:00 - Introduction  00:03:57 - The science of digestion  00:09:34 - Supplementation and chronic illness  00:12:14 - Animal studies  00:15:31 - Current research  00:17:56 - Surge in digestive issues  00:21:36 - Dosing enzymes  00:26:43 - Digesting protein & amino acids  00:30:14 - Improving digestion 00:32:08 - HCL production & immune strength  00:35:28 - High protein diet  00:37:55 - Healing an inflamed gut  00:43:23 - Product integrity  00:47:40 - Lifestyle change recommendations  00:50:30 - Find the diet that works for you  00:53:35 - Food allergies  00:56:41 - Advice for those struggling with gut problems 01:00:17 - Leaky gut  01:03:32 - How to find BIOptimizers  Sponsored By:  Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Check Out Courtney:  LEAVE US A VOICE MESSAGE Check Out My new FREE Grocery Guide! @realfoodology www.realfoodology.com My Immune Supplement by 2x4 Air Dr Air Purifier AquaTru Water Filter EWG Tap Water Database Produced By: Drake Peterson

Vitality Radio Podcast with Jared St. Clair
#521: Herbal Allies for Detox and Digestion with Jamie Cotter

Vitality Radio Podcast with Jared St. Clair

Play Episode Listen Later Mar 29, 2025 72:22


There are so many methods (and reasons) for detoxifying the body, but herbal tinctures are as tried and true a method as there is. On this episode of Vitality Radio, Jared invites everyone's favorite, Jamie Cotter from WishGarden Herbs, back to the show to share just how nature has provided us with the tools to support our body's natural ability to detoxify. You'll learn how to use tonic herbs for periodic detoxes as well as daily support of the liver and lymphatic system. Jared and Jamie also discuss the age old use of bitters for digestion and chlorophyll for detoxification and oxygenation - liquid sunshine!Products:Wishgarden Herbal RemediesAdditional Information:#420: Fast Relief From Seasonal Allergies Using Some Kick-Ass Herbs with Jamie Cotter#473: Supporting Your Immune System Using Some Kick-Ass Herbs with Jamie Cotter#492: Herbal Remedies for Stress, Sleep, Focus, and Mood with Jamie CotterVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Couch Talk w/ Dr. Anna Cabeca
The Gut-Hormone Link You Need to Know with Steven Wright

Couch Talk w/ Dr. Anna Cabeca

Play Episode Listen Later Mar 28, 2025 48:55


Sometimes, feeling “off” isn't just about stress or aging—it could be your gut trying to tell you something. Your digestion plays a bigger role than you might think, influencing everything from your energy and hormones to your mood and even your sex life. Steven Wright, Functional Medicine Expert and Founder of The Healthy Gut Company, is back to share why gut health is the key to feeling like yourself again. We get into the hidden culprits behind bloating, brain fog, and even intimacy struggles—because, yes, your gut impacts that too! Turns out, simple changes can make a big difference. Steven breaks down how digestive enzymes can transform your digestion, why butyrate is a game-changer for gut healing, and what all of this has to do with hormone balance. We even tackle a topic most people avoid—how gut health can impact erectile function and what men can do about it. If you've been dealing with stubborn symptoms and wondering what's really going on, you won't want to miss this one. Taking care of your gut is one of the best ways to support your body, and it doesn't have to be complicated. And if menopause symptoms have been throwing you for a loop, I've got you—check out my Magic Menopause Program and let's get you back to feeling amazing!   Key Timestamps: [00:00:00] Introduction. [00:04:02] Gut health journey and solutions. [00:08:21] Beyond the everything's toxic paradigm. [00:12:01] Enzyme production and digestion. [00:15:00] Digestive health and food variety. [00:19:42] Intimacy and digestive health. [00:22:02] Enzyme dosage and sensitivity. [00:24:11] Digestive enzymes and aging. [00:27:39] Importance of butyrate for health. [00:32:08] Butyrate and gut health. [00:34:02] Tributyrate vs. Sodium Butyrate. [00:40:20] Erectile dysfunction and gut health. [00:45:49] Estrogen and gut health connection. [00:47:53] Importance of gut health.   Memorable Quotes: "It's not the foods that are wrong, the foods are not the enemy, it's the fact that your body is not capable of digesting these normal everyday foods and we should be looking upstream to what's going on with the body instead of blaming the foods." [00:12:05] – Steven Wright "If it doesn't work, most of the time you have a gut issue that you need to address along with the BHRT. And if you do those things together, everything you're wanting from your program will start to come together." [00:46:08] – Steven Wright   Links Mentioned:  Magic Menopause Program: https://order.magicmenopause.com/ Healthy Gut (Code: DrAnna for 15% off): https://healthygut.com/dranna Holozyme: https://healthygut.com/drannaholo Tri-X: https://healthygut.com/drannatrix HCL: https://healthygut.com/drannahcl HoloImmune: https://healthygut.com/drannaimmune Mag-HP: https://healthygut.com/drannamaghp Beserene Bundle: https://healthygut.com/drannaserene HistaHarmony: https://healthygut.com/drannahh   Connect with Steven Wright: Website: https://healthygut.com/ Instagram: https://www.instagram.com/healthygutco/   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

The Cabral Concept
3334: Weak Immune System, Methylene Blue & Petroleum, White Lines on Nails, Infant Stool, Topical Steroid Withdrawal (HouseCall)

The Cabral Concept

Play Episode Listen Later Mar 23, 2025 17:39


Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Lara: Hi, dr. Cabral! Hope you & your family are doing well.. I've heard from a trusted source that people who never get sick actually have a bad immune system response.. that it means their immune system doesn't recognise a threat (virus for example) & that's why they never get sick.. but that doesn't make sense to me, wouldn't that just mean that the viruses would then just stay in your body if your immune system wouldn't try to fight them? And they would wreak havoc on it? I don't know if my way of thinking is correct but would love to hear your input on this.. thanks for all you do, you're absolutely amazing!                                                                                                                                                                             Anonymous: Hello, I am wondering in methylene blue. I found one of your podcasts where you mention it in a positive manner but now I am hearing about it being derived from petroleum?! So is it a synthetic petroleum-derived chemical? Or is it a great bio hacking tool? I don't believe it can be both, but I know too little about it. Would love a whole show on it from your perspective, if possible, because it's supposed to have so many benefits, but how if it's made this way? Thanks     Sarah: Hello!! Curious about the white lines on my nails. I've had them on and off throughout my life. I heard it could be about nutrient deficiencies. I've done the HTMA and completed a protocol to balance my minerals, I eat a clean whole food diet, I take HCL with my meals to help digestion. I also get a lot of random bruises on my legs, unsure if this is related. I've done the 7 day detox, CBO and heavy metals protocol, I take the DNS also zinc and omegas, aswell as l glutamine, creatine, collagen, vit D and some adaptogens. I dry brush, gua sha, rebound, sauna, exercise, lots of walking etc. Anything to be concerned about with the white lines on nails/bruising on the legs? Thanks so much for all you do      Linda: Hey Dr Cabrel,I am writing about my granddaughter. She is almost 6 months old, breech cesarean birth baby, fully breast feed. My daughter is very health conscience, gluten free dairy free for years for her own health, lives as toxic free as possible. My question is the baby started to have some blood in her stool around 2 months which the Dr said is a reaction to what my daughter eats. She has limited so many things and eats the same thing every day. They think eggs/chicken are a big trigger as well as oats. Where do we go to find help. The Drs really dont have much to say for guidance and she is getting to an age to start with solids. Thanks!                                                                                            Slava: Hello, To Stephan Cabral: Have you ever dealt with a patient that was going through TSW (topical steroid withdrawal) symptoms? Currently on day 16 for the CBO protocol, have done the big 5 lab tests in 2023. Used corticosteroids since 2020. Any help is appreciated. Thanks!     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3334 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

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Medical Medium Podcast
084 Parasite Confusion: Do You Have Parasites?

Medical Medium Podcast

Play Episode Listen Later Feb 6, 2025 35:06


Even though parasites are not the cause of chronic mystery illness, they are becoming the new, trendy belief system and health-spin of the day. There are even professionals in the health industry toting how all of people's problems are caused by parasites, meanwhile the same people, just a few years ago, like so many others, weren't even aware of the basics when it came to pathogens and toxins. The truth is, parasites do not give people long-term chronic illness, but viruses and bacteria do. There is another confusion around parasites and it's worms—worms are worms and not parasites, viruses or bacteria. People can live with most worms for a lifetime and feel good, while a twenty- or twenty-five-year-old could be bedridden with fatigue, brain fog and body pain and no worms are even present. Foodborne illnesses are parasites, and parasites either kill or be killed—there is no in-between. In this intense episode, learn the causes of chronic illness and the differences between parasites and stealth pathogens… In this episode… • Learn about the parasitical scam going on out there, what it is and how it's misleading people. • Discover the litany of trendy biohack movements that come-and-go, leaving behind not only a great big hole in the health world, but people who are sick, exhausted and answerless. • Uncover what parasites are and just how many and where you come into contact with them every single day. • Learn how your HCL kills off parasites left and right, what can cause weakened HCL and how weakened HCL can impact your health. • Discover what a powerful, lasting parasitical infection can do to the body. • Uncover the kill-or-be-killed mantra that parasites live by. • Learn about how it's you win or the parasite wins, but you can't live long-term with a parasite. • Discover how most parasites are harmless because our HCL kills them off fast. • Uncover what people are really living with that's impacting their health daily, and it's not parasites. • Discover how Medical Medium broke barriers when it came to the reasons behind chronic illness and ways to actually heal. • Uncover tools & resources you can use to better your health. • Learn how the parasitical protocols have changed as of late and where their information is coming from. All this and more, tune in and don't miss out on this important episode. You can revisit this episode anytime you need it. For more information visit www.medicalmedium.com