Podcasts about lesche

In this episode of the Epigenetics Podcast, we talked with Tomohisa Toda from the Max-Planck-Zentrum für Physik und Medizin about his work on the long-term maintenance of neuronal identity, with a focus on epigenetic and RNA-based mechanisms in brain stability and aging. Dr. Toda describes how brain circuits are stabilized over time, why critical periods are temporally restricted, and how epigenetic regulation may help maintain established neural identity. This led him to postdoctoral work on neural stem cells and long-term maintenance. We cover his work on nuclear pore and nuclear lamina proteins, including NUP153 and Lamin B1. He explains that NUP153 is enriched in neural stem cells and appears to act as a platform for recruiting factors that help maintain the stem cell epigenome. For Lamin B1, we discuss its decline during aging, how its loss can lead to stem cell exhaustion, reduced adult neurogenesis, and age-related mood dysregulation in the hippocampus. We also discuss LINE-1 RNA, where we learn that reducing LINE-1 promotes neural progenitor differentiation. He explains that this effect is linked to the RNA sequence itself rather than retrotransposition, based on rescue experiments. Finally, we talk about his finding that a subset of postnatally born brain cells contains nuclear RNAs that remain detectable for up to two years. He describes their nuclear enrichment, possible association with heterochromatin, and ongoing work to understand their sequence features, modifications, and biological function. References Bedrosian, T. A., Houtman, J., Eguiguren, J. S., Ghassemzadeh, S., Rund, N., Novaresi, N. M., Hu, L., Parylak, S. L., Denli, A. M., Randolph-Moore, L., Namba, T., Gage, F. H., & Toda, T. (2021). Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. The EMBO journal, 40(3), e105819. https://doi.org/10.15252/embj.2020105819 Zocher, S., McCloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche, M., Rund, N., Gage, F. H., Hetzer, M. W., & Toda, T. (2024). Lifelong persistence of nuclear RNAs in the mouse brain. Science (New York, N.Y.), 384(6691), 53–59. https://doi.org/10.1126/science.adf3481 Zhilina, D., Bolaños Castro, L. A., Eguiguren, J. S., Zocher, S., Karasinsky, A., Widmer, D., Espinós, A., Borrell, V., Brand, M., Miura, K., Zierau, O., Yun, M. H., & Toda, T. (2026). Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain. Developmental dynamics : an official publication of the American Association of Anatomists, 255(2), 187–208. https://doi.org/10.1002/dvdy.70023 Related Episodes Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel) Single Cell Epigenomics in Neuronal Development (Tim Petros) The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Dr. Johanna Hanink, a professor of Classics at Brown University, joins Lexie for a podcast centric episode, in which we dive into the origins and inspirations that led to the creation of her podcast Lesche. Our conversation covers the inspirations she took from other podcasts like Byzantium and Friends, the challenges of balancing academic rigor with creating accessible content, to her approach to preparing for interviews. It also highlights the importance of fostering a hype culture within academia and future plans for the podcast. So tuck in your togas and hop aboard Trireme Transit for this week's exciting odyssey! Don't forget to follow us on Twitter, Facebook & Instagram or visit our website www.theozymandiasproject.com! Originally recorded April 8, 2025.Learn more about Dr. Hanink: https://www.johannahanink.com/Check out Lesche podcast: https://www.leschepodcast.com/2388571 Follow Lesche on Instagram: https://www.instagram.com/leschepodcast/Support us on Patreon: https://www.patreon.com/TheOzymandiasProject Custom music by Brent Arehart of Arehart Sounds and edited by Dan Maday. Want a transcript of the episode? Email us at theozymandiasprojectpodcast@gmail.com and we can provide one. Hosted on Acast. See acast.com/privacy for more information.

1/22/24 Special Guest: George and Pam Lesche of Predator ToolsWebsite: www.Predatortools.comTreasure Vortex took over All Metal Mode Podcast Jan. 2022.Co-hosts are Gypsy Jewels:Website- https://gypsydigs.com/tiktok- https://vm.tiktok.com/TTPdrSw2aL/Youtube- https://youtube.com/c/ZeroDiscriminationInstagram- https://instagram.com/gypsies_jewels?utm_medium=copy_linkAnd Amanda Digger DegazTiktok- https://vm.tiktok.com/TTPdrSc6cx/Youtube- https://youtube.com/c/ADiggerDeGazInstagram- https://www.instagram.com/invites/contact/?i=op1wgcfzm9mc&utm_content=40kz54Treasure Vortex Facebook group- https://www.facebook.com/groups/treasurevortex/?ref=shareTheme Music by Porks and BeansIan Loch- Guitar, Bass, Train WhistleRon Gallant- Vocals, Drums, WashboardJon Hernandez- Banjo, Mouth harp

Germany is one of the European countries with higher healthcare expenditures. 11% of GDP goes to healthcare compared to the 9.6% European average. Patients can be covered under public health insurance, or if they earn more than 5000 euros monthly, they choose from private health insurance providers. Health insurance is mandatory but competitive as there are around 100 health insurance companies on the market.  When Jens Spahn became the health minister In March 2018 Germany quickly became the European northern star of accelerated healthcare digitization. How did they do it? You will hear from three speakers - Henrik Matthies, managing director of the health innovation hub of the German Ministry of Health, Maren Lesche - Head of Incubation at Vision Health Pioneers a pre-seed incubator ‘Vision Health Pioneers’ based in Berlin and dr. Maike Henningsen - medical doctor, who specialized in OBGYN, oncology, endocrinology and reproductive medicine and who partially still works in the clinical practice but is also involved in Vision Health Pioneers as Head of Medical Business Strategy and involved in several other innovation projects.  

Join Dennis Wynne and myself as we talk with the Lesche's from Predator tools

Join Dennis Wynne and myself as we talk with the Lesche's from Predator tools

Listen for your chance to win a Predator Tool shovel.On this show we talk with Steve Fenner, our XP Team USA field rep from Virginia about some of his great finds in an area enriched with American history. We also talk with our dealer of the month of January George and Pam Lesche with Predator Tools. We also announce our give away contest for a Super Relic Pro Model 81 shovel by Predator Tools. So listen to find out how to win. http://xpdeus-usa.com/https://www.predatortools.com/https://www.facebook.com/groups/xpdteamusa/?ref=bookmarks

We discuss Predator tools with the Lesches

We discuss Predator tools with the Lesches

Join me as I talk to George and Pam Lesche about Predator Tools

Join me as I talk to George and Pam Lesche about Predator Tools

Join us as we talk to George and Pam Lesche from Predator tools

Join us as we talk to George and Pam Lesche from Predator tools

You have probably seen his tools in 90% of the metal detecting videos on YouTube. And he will be on the air with me for a great discussion on his tools and stories of which I hear he has many.

You have probably seen his tools in 90% of the metal detecting videos on YouTube. And he will be on the air with me for a great discussion on his tools and stories of which I hear he has many.