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On this episode of Diabetes Connections In the news… The FDA approves a new indication and health benefit for Mounjaro, lots of CGM news including an update on Medicare coverage for people who don't use insulin and a new study about using CGM when you don't have diabetes, metformin and aging, statins and type 2, and did you know there was a Dolly Parton diabetes connections? That and much more... Check out all of our events like Moms' Night Out and Club 1921 here. Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  On this episode of Diabetes Connections In the news… The FDA approves a new indication and health benefit for Mounjaro, lots of CGM news including an update on Medicare coverage for people who don't use insulin and a new study about using CGM when you don't have diabetes, metformin and aging, statins and type 2, and did you know there was a Dolly Parton diabetes connections? That and much more.. that's coming up right after this. (AD BREAK) Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bring you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. Welcome to September! Want to let you know about a webinar I'm doing with Abbott later this month. That's Sept 23 at 7pm ET. We'll be talking about ketones, DKA and learn more about their dual CGM/ketone monitor that was just approved – more on that coming up. But please register – the link is in the show notes. So much going on over here – tomorrow night we have our Club 1921 in Charlotte, later this month Moms' Night Out Detroit/Bloomfield and in October we're going to Seattle. Please join us. More at d-c dot com slash events. Okay.. our top story this week: XX Another indication for Mounjaro – the FDA approved it to lower the risk of major adverse cardiovascular (CV) events (MACE), including CV death, non-fatal heart attack, or non-fatal stroke in adults with type 2 diabetes who are at high risk for these events. Mounjaro – the brand name of tirzepatide - is already approved as an adjunct to diet and exercise to improve blood sugar in adults and children 10 years of age and older with type 2 diabetes. The approval was based on results from the largest and longest tirzepatide study to date, enrolling more than 13,000 participants across 30 countries over more than four and a half years. In the trial, Mounjaro demonstrated non-inferiority to Trulicity (dulaglutide), a GLP-1 treatment with established cardiovascular benefit, with an 8% lower rate of cardiovascular death, heart attack or stroke (MACE-3). The estimated hazard ratio for time to first MACE was 0.92 (95.3% CI: 0.83, 1.01) for Mounjaro compared to Trulicity (dulaglutide). https://www.prnewswire.com/news-releases/fda-approves-lillys-mounjaro-tirzepatide-to-reduce-cardiovascular-risk-in-adults-with-type-2-diabetes-302862415.html XX The FDA approves the Libre Duo – the first device designed to continuously monitor both blood sugar levels and ketone levels in people with diabetes. The Libre Duo 10-Day Continuous Dual Glucose Ketone Monitoring System is now approved for those ages 2 and older. Until now, the agency said, people had to monitor ketone levels with separate tests that only provided a single measurement at one point in time. The new system combines blood sugar and ketone tests and monitors them continuously. Readings -- and alerts in case of dangerous trends -- are sent wirelessly to a smartphone app. The FDA previously granted "breakthrough device" status to the system, which is meant to expedite the device's development and review. https://www.upi.com/Top_News/US/2026/08/25/fda-oks-blood-sugar-ketone-monitor/5521787688375/ XX Diabetes tech firms Dexcom and Abbott are watching closely for a Medicare coverage expansion that could significantly broaden access to their glucose sensors. The Centers for Medicare and Medicaid Services is expected to expand Medicare coverage of continuous glucose monitors to people with diabetes who do not take insulin. Currently, coverage is limited to people with Type 1 or Type 2 diabetes who take insulin or have a history of problematic low blood sugar. Dexcom CEO Jake Leach told investors in a late July earnings call that the company expects to hear back from the CMS before the end of the year, with coverage going into effect in mid-2027.     Dexcom presented results of a randomized, controlled trial earlier this summer at the American Diabetes Association's Scientific Sessions that it expects will support the CMS' decision. The 26-week study found that people who used a CGM had a larger hemoglobin A1C reduction than the control group and spent five more hours per day in a normal glucose range than the control group. https://www.medtechdive.com/news/dexcom-abbott-await-medicare-coverage-expansion-for-cgms/828775/ XX A new study suggests continuous glucose monitors (CGMs) may offer benefits for people with type 1 diabetes that go beyond improving blood sugar and reducing hypoglycemia.   Researchers analyzed health records from more than 8,400 adults with type 1 diabetes receiving care through the Veterans Health Administration. Over one to four years of follow-up, people who started using a CGM had a 10% to 16% lower risk of death from any cause compared with those who did not use one.   The association appeared strongest among people over age 65 and those who were not using insulin pumps. Researchers did not find meaningful differences based on A1C, race or ethnicity, or frailty.   Importantly, this was an observational study using medical records, not a randomized clinical trial, so it cannot prove that CGM use directly caused the lower death rate. But the findings suggest CGM may have important long-term health benefits beyond glucose management.https://visualize.jove.com/42319755-continuous-glucose-monitoring-initiation-is-associated-with-reduced-mortality-in-older-onset-type-1-diabetes-patients-a-target-trial-emulation-study-within-the-veterans-health-administration XX We've been talking about people without diabetes using CGMs for a long time.. now a new study weighs in. Research published in JAMA finds that this wellness trend isn't helpful for people without a diabetes diagnosis. They found that the strongest evidence for CGM use is for people who are already living with diabetes, but not for those without the condition who use them for wellness purposes. It's also worth noting, though, that this new study is a narrative review. This means that the researchers drew their conclusions from the findings reported in several other studies. More randomized controlled trials would be necessary to see whether there are any meaningful health benefits of using a CGM if you don't have diabetes.   Dower also warned that constantly monitoring your blood sugar when you don't have diabetes could lead to unintended health anxiety. In some cases, you may even make accidental lifestyle changes that could be harmful. "[Blood sugar] spikes may occur after meals, but if this leads someone to replace healthy food such as fruit with unhealthy food such as something high in fat but low in carbohydrate, the glucose information has done more harm than good," Dower said. https://www.verywellhealth.com/blood-sugar-monitor-for-people-without-diabetes-12058575   XX   Could metformin somehow influence the biological processes that drive aging? A new review found evidence that metformin may affect several key features of aging, including how cells use energy, inflammation, cellular damage and even some changes in gene activity. Animal studies have shown longer lifespans or improvements in markers of biological aging, while some human studies have also found promising results.   But researchers say there's still no proof that metformin actually slows aging or helps healthy people live longer. Most human research has involved people with diabetes or other health conditions, and one large trial found that while metformin helped prevent type 2 diabetes, it did not reduce cancer, cardiovascular disease or deaths.   Researchers say larger clinical trials in people without diabetes are needed to determine whether metformin can truly extend healthy lifespan—or whether its benefits are primarily related to preventing and treating specific diseases. https://www.technologynetworks.com/drug-discovery/news/metformin-may-influence-longevity-through-the-gut-microbiome-and-epigenetic-changes-416035 XX More to come including more research on a spice thought to help diabetes, predictions about the number of people who may be living with type 1 in the years to come around the world, and a connection I didn't know about between diabetes and Dolly Parton.   XX A compound found in turmeric may help protect blood vessels from some of the damage caused by Type 1 diabetes. In rats, curcumin reduced inflammation, improved cellular signaling, and restored vascular health to levels resembling those of nondiabetic animals. The results hint at a possible new way to reduce the long-term cardiovascular risks of diabetes, but human trials are still needed. Curcumin, the natural compound responsible for turmeric's vivid yellow color, is widely studied for its anti-inflammatory and antioxidant properties. https://www.sciencedaily.com/releases/2026/08/260824065543.htm XX New research estimates the number of people living with type 1 diabetes (T1D) worldwide will increase by 29% from 9.4 million in 2025 to 12.1 million in 2049. This will be presented at EASD, the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2 The USA will see an increase of over half a million, going from 1,492,825 to 2,055,235. The authors suggest that the reasons for the predicted high incidence and prevalence in 2049 in countries such as Australia, US, UK are likely to be a combination of genetics, environmental triggers and also high case detection rates (due to the good health care infrastructure here and in other HIC). Unlike previous estimates, the DIAMOND-T1D model takes historical patterns of insulin availability into account and aims to provide global, regional and country-specific estimates of T1D incidence, prevalence and mortality from 1900 to 2050. Although the majority of people with T1D live in high-income countries (HIC) and middle-income countries (MIC), the largest relative increase in the T1D prevalence is expected to occur in LIC as access to insulin, glucose monitoring and survival all improve in those countries. https://www.news-medical.net/news/20260828/Type-1-diabetes-cases-projected-to-increase-worldwide-by-2049.aspx XX Early initiation of statins after a diagnosis of type 2 diabetes was associated with a lower risk of dementia, according to a study published in The Lancet Regional Health – Europe. According to the Lancet Commission, nearly half of dementia cases could theoretically be prevented by eliminating 14 risk factors. "Detecting and treating high levels of low-density lipoprotein cholesterol (LDL-C) from midlife is one such highlighted risk factor," From Danish registers, researchers identified 132,585 statin-naive individuals who developed type 2 diabetes from 2006 through 2019, with follow-up until the end of 2021.   Medical records were searched for diagnoses of all-cause dementia. A clone-censor-weight design was used to analyze dementia incidence in patients with no statin initiation within five years after diagnosis, in those with early statin initiation within one year and in those with late statin initiation between one and five years after diagnosis.   https://medicalxpress.com/news/2026-08-early-statins-diagnosis-diabetes-dementia.html   XX We are heartbroken over the loss of our friend Dolly Parton. Dolly was a beloved icon whose extraordinary generosity, warmth, and compassion touched countless lives, including those of the Children's Diabetes Foundation and the Barbara Davis Center for Diabetes. Her support of The Carousel Ball and Carousel of Hope Ball reflected her deep commitment to helping children and families affected by type 1 diabetes. Beyond her remarkable talent, Dolly will be remembered for the kindness and joy she shared so generously with others. Our hearts are with her family, friends, and all who loved her as we celebrate her extraordinary life and lasting legacy. She will be deeply missed.    

Have you ever wondered how trolls, bots, and paid influencers are quietly manipulating what you see online and why even smart, skeptical people fall for it? Today, disinformation expert Dr. Darren Linvill pulls back the curtain on the tactics that bad actors are using to try and shape our beliefs.    In this episode, Therese Markow and Dr. Darren Linvill discuss the various forms of digital deception and the strategies used by state actors to manipulate global discourse. Dr. Linvill distinguishes between misinformation, disinformation, and malinformation and gives examples of each, including tactics used by different international organizations from Iran, China, Israel, North Korea, and others. He also discusses the psychological impact that this disinformation has on humanity.     Key Takeaways: Fraud is the oldest form of disinformation, and it's rampant across social media. It's a multi-billion-dollar industry.  The main way that AI is being used right now to disseminate false information, disinformation, whether it's fraud or political disinformation, is the scale at which this content is created.  Sometimes there is not enough information to attribute disinformation accounts to a specific person or group. Sometimes it can be traced either through the content being posted or similar information on other websites.  At the end of the day, people will believe what they want to believe, regardless of whether it is true or has been fact-checked as false.    "At the end of the day, all of us humans are emotional animals. And we are interpreting the world around us, including the information we find on social media, through an emotional lens, especially when it comes to the communities that we're a part of, and our emotional attachments to those communities and our emotional needs that we derive from those communities, that absolutely affects the lens through which we interpret information." —  Dr. Darren Linvill   Episode References:  Clemson University Media Forensics Hub: Spot the Troll - https://spotthetroll.org/    Connect with Dr. Darren Linvill: Professional Bio: https://www.clemson.edu/cbshs/about/profiles/darrenl  Twitter: https://x.com/DarrenLinvill?lang=en   LinkedIn: https://www.linkedin.com/in/darren-linvill-6673655b  Google Scholar: https://scholar.google.com/citations?user=gQl4PlQAAAAJ&hl=en    Connect with Therese: Website:  www.criticallyspeaking.net Bluesky: @CriticallySpeaking.bsky.social Instagram: @criticallyspeakingpodcast Email: theresemarkow@criticallyspeaking.net   Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it. 

Episode 265: Ryan Fuller started questioning online reviews after two terrible stays at highly-rated vacation rentals. Both had 4.9-star ratings. After Ryan posted negative reviews, the people behind each listing independently offered him £200 to change his review to five stars.  "It was disappointing," he said, "that clearly many people took them up on this offer." On the flip side, the experience explained something that had been bothering him for a while: Places with thousands of positive reviews could still turn out to be terrible. So Ryan, founder of Larrocos Labs and a serial entrepreneur, decided to investigate.  He built an AI system that has now analyzed hundreds of thousands of reviews covering roughly 22,000 restaurants. One example of what he found: In a focused analysis of 4,000 restaurants, about 70% showed at least one unusual review pattern. Some had sudden bursts of five-star reviews. He found one case in which roughly 100 reviews had been submitted within a two-minute period. Others featured suspiciously similar language, unusual concentrations of reviews mentioning particular employees, or reviewers whose histories raised questions about their credibility. None of that proves a review is fake. As Ryan explains, the goal is not to establish absolute truth, but to determine how much confidence we should place in what we are seeing. Ryan discusses what this means for consumers, platforms, and anyone relying on AI-generated information. He also explores an alternative: systems that show their work, identify potential sources of distortion, and tell us how confident they are rather than presenting uncertain conclusions as facts. He sums it up well: "I think we're living in a world where understanding what is real or what is true is going to become one of the most difficult problems for humans to deal with." Guest: Ryan Fuller, Founder, Larracos Labs  Host: Rob Markey, Partner, Bain & Company Give us feedback: Customer Confidential Podcast Feedback Send us a note: Contact Rob Timestamped Topics 00:39 – How two 4.9-star vacation rentals led Ryan to question online reviews 03:11 – Why hours spent researching restaurants became a problem worth solving 04:49 – Using AI to automate the process of assessing restaurant reviews 05:26 – Building a database of 22,000 restaurants in six months with 300 lines of code 06:15 – Finding unusual review patterns across 70% of a 4,000-restaurant dataset 07:20 – Identifying sudden clusters of ~100 reviews for one restaurant 08:10 – Treating suspicious review activity as a question of confidence 08:40 – Using repeated staff names and customer incentives as review signals 09:12 – Detecting reviews that describe offers of money for positive ratings 11:05 – Assessing reviewer credibility through history, photos, and detail 12:11 – Building an AI product that checks authenticity and extracts review data 13:01 – Evaluating restaurant experiences across 36 distinct dimensions Notable Quotes 18:00 "I think with AI, it's like rocket fuel, where things can be done at incredible scale and with high degrees of believability in ways that were never true before. I think we're living in a world where understanding what is real or what is true will become one of the most difficult problems for humans to deal with on even just everyday stuff like picking a restaurant." 26:00 "Platforms that start to be more transparent about sources and degree of confidence and potential risks for any information they're providing will become more popular." 28:00 "It's almost just like an arms race. There's no sudden advance in tech or approach that's gonna solve the problem. I'm just pontificating here; I don't have good answers, but I do think this is maybe the problem of our time." 33:00 "The devious thing about AI is that it sounds so credible; we're going through a transitional phase where we're not as well attuned to what the tells are when confidence isn't there." 37:00 "I always try to show the work. One thing we do is we have a letter grade that we assign each restaurant for overall quality. So, it can be an A, a B-plus, whatever. And the very first thing underneath the score, the overall letter, is why it got a B-plus." Additional Resources Read Ryan Fuller's analysis of unusual patterns and manipulation in London restaurant reviews: https://www.linkedin.com/posts/ryantfuller_london-ai-share-7399118135099973633-Iquu/ See Ryan Fuller's restaurant data visualizations and discussion of how platform algorithms shape restaurant visibility: https://www.linkedin.com/posts/ryantfuller_datavisualization-londonlife-urbananalytics-ugcPost-7404913381431844864-cM7l/ Here's the article referenced about how a man created his own top-rated Dulwich restaurant: I Made My Shed the Top Restaurant on TripAdvisor: https://www.vice.com/en/article/i-made-my-shed-the-top-rated-restaurant-on-tripadvisor/

Angela DiFulvio explains a theoretical method for detecting nuclear weapons in low Earth orbit to prevent catastrophes like the 1962 Starfish Prime experiment, which destroyed a third of existing satellites. She describes an "inspector" satellite designed to induce a unique radioactive signature from fissile material using high-energy protons. DiFulvio details technical challenges, such as "pulse shape discrimination," to distinguish weapon-related neutrons from background cosmic radiation in the harsh space environment. She suggests that an international agency like the IAEAmight oversee these inspectors to ensure space remains weapon-free. DiFulvio emphasizes that while tests can occur in classified environments, more research is needed on the survivability of sensing electronics. She warns that a modern orbital nuclear detonation would be catastrophic for global infrastructure, specifically mentioning the vulnerability of massive constellations like Starlink. (8)

AI is changing hiring in ways that go far beyond candidates using ChatGPT to answer interview questions. The harder problem is knowing whether the person on screen is actually who they claim to be, whether their answers are their own, and what happens if someone with malicious intent gets access to company systems.Yagub Rahimov, CEO and founder of Polygraf AI, joins The Tech Trek to discuss the growing trust problem surrounding AI assisted interviews, deepfakes, impersonation, and security. He explains why organizations need more visibility into the hiring process without turning every unusual behavior, accent, or response into a reason for suspicion.What You'll Take Away• AI interview fraud is not simply a recruiting problem. Once someone enters the company, identity and access become security concerns.• Detecting suspicious candidates based on human intuition alone can create false positives. Rahimov argues for using technology to create evidence and visibility.• Small pieces of public information can reveal far more about a company than leaders realize when they are combined through what Rahimov calls mosaic intelligence.• Protecting company information means thinking beyond traditional security controls to what employees, executives, and systems expose publicly.Key Moments02:27 How AI tools can turn legitimate technology into an interview cheating mechanism05:35 Why hiring fraud can become a security and data access problem07:43 Using voice, conversation context, and AI detection to improve visibility during interviews11:43 Why increased AI uncertainty should not lead companies to distrust everyone14:28 What organizations should think about after a candidate actually gets hired19:40 The continuing race between increasingly capable deepfakes and detection technologyOne Line That Stuck“Tech problems have tech solutions.”Follow The Tech Trek for more conversations about AI, engineering, data, product, and how technical teams are adapting.

John Karageorge, head of S&P's activist defense surveillance group, discussed how corporations can identify activist accumulations before they become public. 

João Moura built a fraud detection platform operating in 188 countries not by making fraud prevention safer, but by turning it into a growth lever. This conversation gets into how organized crime runs modern fraud, why siloed data guarantees you'll lose, and how connecting institutions across borders changes everything.What you'll learnWhy 70% of fraud today is backed by organized crime networks, and what that means for your detection strategy (02:46)How mule accounts operate as layered networks across institutions and why catching one account misses the point (32:20)What false declines actually cost you in revenue, customer trust, and operational overhead (09:03)How fraud detection becomes a growth enabler when it lets acquirers onboard merchants same-day with confidence (20:19)Why connecting data across institutions creates a network effect that makes every client's fraud model stronger (28:40)What the third generation of AI-powered fraud detection looks like and why it's fundamentally different from siloed models (14:45)How agentic AI introduces a new authorization problem that nobody in payments has solved yet (37:15)What João learned about distribution, decisiveness, and sunk cost fallacies after spinning Fraudio out of a bank (46:20)TIMESTAMPS1:35 João's background: 20 years in AI before it was cool2:46 How organized crime powers modern fraud7:55 The real cost of false declines on revenue and customers14:45 Three generations of AI fraud detection explained16:34 How generative AI acts as a force multiplier for fraud teams20:19 Detecting fraudulent merchants before chargebacks arrive25:13 How much fraud Fraudio actually stops: the numbers28:40 The Philippines rule that becomes available to 188 countries32:20 Why mule accounts are really mule networks37:15 Agentic AI and the unresolved authorization problem43:30 The lazy insight that became Fraudio46:20 What João learned: distribution, decisiveness, and sunk cost fallacies

Siyabonga Motha, standing in for Aubrey Masango, speaks to Brad Latilla-Campbell, Country Manager at Crimson Education, on why universities across the world are dropping AI detection tools. They also touch on the future of higher education that now incorporates artificial intelligence and how that will work in industry. You’re listening to The Aubrey Masango Show with Aubrey Masango, where real conversations meet expert insights – from politics to life, personal finance, and more. Thanks for listening. Listen live on 702 weekdays from 8 pm to midnight, or on CapeTalk from 8 pm to 9 pm (South African time) https://buff.ly/gk3y0Kj For more from the show and catch-up podcasts, visit Primedia+ here https://buff.ly/gk3y0Kj Subscribe to the 702 Daily and Weekly Newsletters https://buff.ly/v5mfetc Keep the conversation going online: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/capetalkza/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

Sponsor Link:NordVPN - Safeguard your online activity with our exclusive offer for Space Nuts listeners. Visit www.nordvpn.com/spacenuts for details.From SpaceX Nuclear Experiments to Galactic DiscoveriesJoin host Andrew Dunkley and astronomer Fred Watson as they explore some of the most fascinating topics in space science, from innovative nuclear power tests in space to the expanding boundaries of our galaxy. Whether you're an astrophotography enthusiast or a space policy advocate, this episode delivers insights that broaden your cosmic perspective.In this episode:SpaceX's recent CubeSat launch featuring a tritium-based nuclear power source for space applicationsThe potential and safety considerations of nuclear energy in space missionsThe possibility of nuclear weapons detection in space using neutron sensors and passive radiation monitoringThe intriguing hypothesis of dark matter stars and their potential signaturesThe mystery surrounding Earth's dust origins—cosmic spherules and their unknown sourcesNew research indicating our galaxy's spiral arms are about 10% longer than previous estimates, based on light echoes from gamma ray burstsThe rise of smart telescopes and their role in making astrophotography more accessible for amateursTimestamps:(00:00) Introduction and overview of today's headlines(02:00) SpaceX's CubeSat with tritium power source—what's happening?(04:33) Nuclear power in space: Safety and future applications(11:03) Detecting nuclear weapons in space: Challenges and innovations(22:45) Earth's dust origins: Micro-meteorites and cosmic spherules explainedResources & Links:SpaceX's CubeSat nitrogen launch storyBeta-voltaic nuclear power technologyNASA's Chandra X-ray ObservatoryUniverse Today article on Milky Way mappingJames Webb Space Telescope and dark matter researchScience Advances publication on Earth's micrometeoritesConnect with Fred Watson:LinkedInTwitterEnjoying the show? Support us on Patreon and leave a review on your favorite podcast platform.Thanks for tuning in and keep looking up!Become a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.

Join us tonight with detectorist Andy Hughes to discussing his amazing gold torc over 3000 years old find among other amazing things he has found.Sponsored by Metal Detecting NewsBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-big-detecting-show--3690873/support.

What happens behind the scenes to ensure new therapies are safe for patients? In this episode of Moving Medicine Forward, we are joined by John Kane, Vice President of Pharmacovigilance and Safety Services at CTI, to explore the critical role of drug safety throughout the clinical development process. John shares how safety teams collect and evaluate adverse event data, navigate complex global regulations, and help protect patients from clinical trials through post-market surveillance. He also discusses the growing impact of AI in pharmacovigilance, the continued growth of North Carolina's Research Triangle, and the rewarding career opportunities available in clinical research. 01:13 – Finding a Career in Clinical Research John shares how he transitioned from nursing into the clinical research industry.  02:14 – CTI's Growth in Raleigh Why North Carolina's Research Triangle continues to attract biotech companies and research talent. 04:55 – Understanding Pharmacovigilance What pharmacovigilance is and how safety teams collect, evaluate, and report adverse events throughout a drug's lifecycle. 07:33 – Protecting Patients Through Drug Development How CTI safety teams monitor risks, identify safety signals, and communicate important findings to regulators and investigators. 09:55 – Navigating Global Regulations The growing complexity of global safety reporting requirements and regulatory compliance. 11:51 – The Role of AI in Drug Safety How AI may improve data processing, signal detection, and scientific literature review. 13:53 – A COVID-19 Success Story John reflects on supporting a large COVID-19 trial and managing high volumes of safety data. 14:38 – Collaboration at CTI Why teamwork and collaboration are key to successful clinical trials and patient impact.  15:32 – Advice for Future Research Professionals Career opportunities in clinical research and how CTI helps new professionals enter the field.

Discoveries on Mars, the Hubble Tension, and Dark Photons - Space Nuts EpisodeJoin Andrew Dunkley and Professor Fred Watson as they explore the latest developments in space science—from evidence of complex organic molecules found by the Perseverance rover on Mars that may hint at past life, to the ongoing mystery of the Hubble tension that challenges our understanding of the universe's expansion. Plus, a deep dive into the elusive concept of dark photons and their potential role in explaining dark matter.Key Topics:The significance of complex carbon molecules detected in Martian rocks by Perseverance and their implications for extraterrestrial lifeThe challenges and prospects of returning samples from Mars and the influence of upcoming Chinese missionsUnderstanding the Hubble tension: different measurements of the universe's expansion rate and what they could mean for new physicsThe role of gravitational wave observations in refining the Hubble constant and resolving cosmological discrepanciesAn introduction to dark photons: what they are and their potential connection to dark matter and dark energyThe nature of cosmic redshift, light travel time, and how we look back in cosmic historyThe possibility of the universe expanding into higher dimensions or higher-dimensional multiversesThe shape and boundaries of the universe: flat, spherical, or saddle-shaped?Resources & Links:Science Advances Paper on Martian Organic MoleculesNASA Perseverance RoverCosmological Parameters and Hubble TensionLarge Hadron Collider Official SiteDark Photons and Dark Matter — University of CaliforniaBiteStop Streaming ServiceConnect with Fred Watson:Professor Fred Watson - LinkedInProfessor Fred Watson - TwitterNote:Stay tuned for future episodes where we continue exploring mysteries of the cosmos, and don't forget to visit our website to send questions or feedback!Become a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.

What do you do when you've built the technology first and the first customer who tries it tells you it's not working at all?Prashant Warrier is the first PhD and the first scientist on Unstarted. A steel-town kid from Bhilai who went from IIT Delhi to a PhD in AI, he came back to India because of a stolen passport — and built Qure.ai, whose AI reads chest X-rays for TB and lung cancer across the world.In this episode, Avnish and Prashant attempt to answer: 1. How do you identify a unique problem is it about passion or market cap?2. How do you know the technology is actually working? 3. How can founders assess whether they're early, late, or correctly timed for a market? 4. Will frontier AI kill vertical businesses or is there domain-specific stuff left to build? 5. Why build a cutting-edge AI company from Mumbai?This episode is in partnership with TEAM — Tech Entrepreneurs Association of Mumbai.Chapters 00:00 Introduction1:41 Steel town to IIT to a PhD in AI3:20 SAP, and the stolen passport that sent him home6:32 Freedom over the US visa rat race8:17 The 2012 breakthrough that started the company11:43 A research lab with no business plan13:33 "A solution looking for a problem"16:52 The reality check & the real bottleneck19:20 TB screening: 4 weeks to 30 seconds21:43 Detecting lung cancer early with AI24:23 Moats, ChatGPT & the future of AI in healthcare32:04 Why Mumbai, and advice to founders

Join Dave and Donner and this week's guest, YouTuber - Chrissy Detects. Learn all about her recent gold and rally visits.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-big-detecting-show--3690873/support.

This episode is built around a ransomware response checklist — a three-part Reddit series by a security specialist who goes by snorkel42, breaking down exactly how to prevent, contain, and recover from a ransomware attack.This is an encore episode, and it's back not just because a lot of people downloaded it originally, but because so many of you listened all the way through — some of you more than once. That kind of engagement told us this one was worth bringing back.Curtis Preston and Prasanna Malaiyandi dig into snorkel42's series, which breaks the whole problem into three parts: how to stop ransomware from getting in, how to slow it down if it does, and what to actually do once you've been hit. Curtis and Prasanna go section by section — covering phishing and dropper prevention, application whitelisting, blocking lateral movement between servers, locking down RDP and SSH, honeypot files for catching intruders in the act, and building a real incident response plan before you ever need one.They also get into the messier parts most people don't talk about — what it's actually like to negotiate for a decryption key, why getting your data back isn't the end of the story, and why a ransomware attack is nothing like a normal disaster recovery scenario. Along the way, Curtis makes the case that most organizations already have the gaps this attacker needs — and that fixing them now is a lot cheaper than fixing them after the fact.Whether you're building your first incident response plan or just want to stress-test the one you've already got, this episode gives you a practical, section-by-section framework to work from.Chapter Markers:00:00 – Encore intro & episode setup00:01:37 – Show intro and banter00:06:21 – Preventing the breach: phishing, droppers, and whitelisting00:14:46 – Blocking lateral movement, RDP/SSH lockdown00:20:28 – Detecting exfiltration and honeypot files00:24:19 – What to do once you've been hit00:25:58 – Building your incident response plan00:30:43 – Decryption, ransom payments, and why it's not over yet

SpaceTime Series 29 Episode 85 Detecting nuclear weapons in space New modelling says small cube-sat sized spacecraft not much bigger than a fridge could be used to detect the presence of nuclear weapons on satellites in space. NASA's rescue mission to save the Swift space telescope reaches orbit NASA's Swift re-boost rescue mission is finally on its way to intercept the gamma ray space telescope and try to save it from its fiery fate. Stopping astronauts from wanting to kill each other on long space trips It can be tough enough getting on with family members at home or the people you have to work with – but imagine what it will be like if you're stuck with a small group of people on a multi-year mission to Mars. The Science Report A new study indicates that people who speak more than one language seem to have younger brains. Warnings that two thirds of Australian adults and a quarter of kids are now overweight or obese. Half of all fatal electric scooter accidents in Sweden are caused by drunk riders. Great news for chocolate lovers with 4 new species discovered. Skeptics guide to the case of the missing peacock.   Our Guests This Week: Professor Chris Kirkland from Curtin University NASA planetary geologist Cynthia Phillips Professor Dorothy Carter from Michigan State University   And our regular guests: Alex Zaharov-Reutt from techadvice.life Tim Mendham from Australian Skeptics  

Join Dave and Adrian with Terry Read to discuss the BIG Dig metal detecting rally over the 21st - 23rd August this yearBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-big-detecting-show--3690873/support.

What changes for you as a developer when the device moves from your pocket to your face? The battery shrinks by an order of magnitude, the thermal budget is whatever won't make your nose uncomfortable, and your mental model of "one process, one device" goes out the window. Rey and Dmitrii talk us through their custom power monitors, how they've extended Perfetto to give a coherent trace across a multi-device system, why robotic arms make surprisingly good QA engineers, and what it takes to catch the kind of regression that quietly costs you thirty minutes of call time. All of this and more is discussed in this episode. Got feedback? Send it to us on Threads (https://threads.net/@metatechpod), Instagram (https://instagram.com/metatechpod) and don't forget to follow our host Pascal (https://mastodon.social/@passy, https://threads.net/@passy_). Fancy working with us? Check out https://www.metacareers.com/. Links Migrating Data Ingestion Systems at Meta Scale: https://engineering.fb.com/2026/05/12/data-infrastructure/migrating-data-ingestion-systems-at-meta-scale/  Timestamps Intro 0:05 Introduction and Setup 1:51 Battery Life Optimization in AI Glasses 1:57 Challenges in Testing and CI Architecture 5:37 Detecting and Managing Power Regression 8:27 Developer Tools and Best Practices 13:04 Advanced Monitoring and Synchronization Techniques 16:53 Advanced Power Monitoring in Wearables 21:26 Real-World Examples of Performance Optimization 23:53 Battery Life Improvements Through Engineering 25:21 Engineering Culture and Performance Mindset 27:49 Continuous Testing and Profiling Strategies 29:36 Balancing Profiling Overhead and Accuracy 32:15 Simulating Real-World Scenarios in Testing 34:27 Best Practices for Efficient Wearable Code 37:21 Outro 40:26  

Join us LIVE as we celebrate this incredible milestone with one of our biggest shows yet. Prizes to be won include:-Nokta Legend 2 Metal Detector-Metal detecting accessories-Merchandise-Plus lots more!We'll also be chatting about:-The latest metal detecting news-Amazing finds from around the UK-Special guests-Live chat with detectorists from around the world-Plenty of laughs along the way as usualLearn more at www.bigdetectingshow.comOr via our app www.bigdetect.comSponsored by Metal Detecting NewsBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-big-detecting-show--3690873/support.

The 40 Most Rage-Inducing Problems in Tech, ZFS vs Cep, Detecting and removing dangerous secrets on dev workstations before Shai-Hulud does and more... NOTES This episode of BSDNow is brought to you by Tarsnap and the BSDNow Patreon Headlines The 40 Most Rage-Inducing Problems in Tech ZFS vs Ceph: Do You Actually Need Ceph? News Roundup Detecting and removing dangerous secrets on dev workstations before Shai-Hulud does FreeBSD sh for MacOS syslogd(8) privileged and non-privileged parts now separate binaries Getting Victoria Logs running on FreeBSD Tarsnap This weeks episode of BSDNow was sponsored by our friends at Tarsnap, the only secure online backup you can trust your data to. Even paranoids need backups. Feedback/Questions Send questions, comments, show ideas/topics, or stories you want mentioned on the show to feedback@bsdnow.tv Join us and other BSD Fans in our BSD Now Telegram channel

Could a blood test finally provide answers for millions living with chronic fatigue syndrome (CFS/ME)? In this episode, Alexandre Akoulitchev and Dmitry Pshezhetskiy reveal a groundbreaking approach using epigenetic biomarkers to detect biological signatures associated with this complex, hard-to-diagnose condition. Their work leverages cutting-edge molecular medicine and translational research to provide earlier, more objective detection of CFS/ME—offering hope for patients who have long struggled with uncertainty and delayed diagnoses. In this conversation, we explore: ·       How a blood-based biomarker test may identify chronic fatigue syndrome more reliably. ·       The role of epigenetics in understanding invisible, multi-system illnesses. ·       The four core symptoms of CFS/ME and why conventional diagnostics often fail. ·       How inflammation and immune signals contribute to fatigue and disease progression. Alexandre Akoulitchev, cofounder of Oxford BioDynamics and creator of the EpiSwitch biomarker platform, and Dmitry Pshezhetskiy, Professorial Research Fellow at Norwich Medical School, bring decades of expertise in molecular biology, genome regulation, and translational research to this discussion. Learn more about Alexandre Akoulitchev here and Dmitry Pshezhetskiy here. Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

We've had endless conversations about aliens and first contact--but what if a conversation with other intelligences is beyond our scope? Dr. Daniel Whiteson, particle physicist at CERN's Large Hadron Collider and professor at UC Irvine, joins us to explore less conventional thoughts on first contact. We look at the challenges of communicating with extraterrestrial intelligences, potential difficulties of communicating via non-terrestrial mathematics and physics, and the possibility that extraterrestrials might actually be terrestrial... but existing as denizens of the dark energy universe. One might be sitting in your lap right now! Join us for the far-ranging discussion. Headlines: Boeing's Troubled Starliner Spacecraft Faces Further Setbacks and Delays NASA Perseverance Rover Finds Promising Clues of Ancient Life on Mars NASA Space Telescope Faces Fiery Descent, Mission Planned to Save It Main Topic: Dark Matter, Particle Physics, and the Search for Extraterrestrial Intelligence UC Irvine's Dr. Daniel Whiteson Discusses Path into Space Science and Particle Physics Exploring Nontraditional Signals for Alien Communication Beyond Radio Waves The Mystery of Ultra-High Energy Particles and Speculation on Artificial Cosmic Rays Challenges of Detecting, Interpreting, and Interacting with Alien Intelligence Implications of Dark Matter for Hidden Civilizations and Parallel Existence Complexities in Communicating with Truly Alien Life and Human-Centric Scientific Assumptions Hosts: Rod Pyle and Tariq Malik Guest: Daniel Whiteson Download or subscribe to This Week in Space at https://twit.tv/shows/this-week-in-space. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit

We've had endless conversations about aliens and first contact--but what if a conversation with other intelligences is beyond our scope? Dr. Daniel Whiteson, particle physicist at CERN's Large Hadron Collider and professor at UC Irvine, joins us to explore less conventional thoughts on first contact. We look at the challenges of communicating with extraterrestrial intelligences, potential difficulties of communicating via non-terrestrial mathematics and physics, and the possibility that extraterrestrials might actually be terrestrial... but existing as denizens of the dark energy universe. One might be sitting in your lap right now! Join us for the far-ranging discussion. Headlines: Boeing's Troubled Starliner Spacecraft Faces Further Setbacks and Delays NASA Perseverance Rover Finds Promising Clues of Ancient Life on Mars NASA Space Telescope Faces Fiery Descent, Mission Planned to Save It Main Topic: Dark Matter, Particle Physics, and the Search for Extraterrestrial Intelligence UC Irvine's Dr. Daniel Whiteson Discusses Path into Space Science and Particle Physics Exploring Nontraditional Signals for Alien Communication Beyond Radio Waves The Mystery of Ultra-High Energy Particles and Speculation on Artificial Cosmic Rays Challenges of Detecting, Interpreting, and Interacting with Alien Intelligence Implications of Dark Matter for Hidden Civilizations and Parallel Existence Complexities in Communicating with Truly Alien Life and Human-Centric Scientific Assumptions Hosts: Rod Pyle and Tariq Malik Guest: Daniel Whiteson Download or subscribe to This Week in Space at https://twit.tv/shows/this-week-in-space. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit

We've had endless conversations about aliens and first contact--but what if a conversation with other intelligences is beyond our scope? Dr. Daniel Whiteson, particle physicist at CERN's Large Hadron Collider and professor at UC Irvine, joins us to explore less conventional thoughts on first contact. We look at the challenges of communicating with extraterrestrial intelligences, potential difficulties of communicating via non-terrestrial mathematics and physics, and the possibility that extraterrestrials might actually be terrestrial... but existing as denizens of the dark energy universe. One might be sitting in your lap right now! Join us for the far-ranging discussion. Headlines: Boeing's Troubled Starliner Spacecraft Faces Further Setbacks and Delays NASA Perseverance Rover Finds Promising Clues of Ancient Life on Mars NASA Space Telescope Faces Fiery Descent, Mission Planned to Save It Main Topic: Dark Matter, Particle Physics, and the Search for Extraterrestrial Intelligence UC Irvine's Dr. Daniel Whiteson Discusses Path into Space Science and Particle Physics Exploring Nontraditional Signals for Alien Communication Beyond Radio Waves The Mystery of Ultra-High Energy Particles and Speculation on Artificial Cosmic Rays Challenges of Detecting, Interpreting, and Interacting with Alien Intelligence Implications of Dark Matter for Hidden Civilizations and Parallel Existence Complexities in Communicating with Truly Alien Life and Human-Centric Scientific Assumptions Hosts: Rod Pyle and Tariq Malik Guest: Daniel Whiteson Download or subscribe to This Week in Space at https://twit.tv/shows/this-week-in-space. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit

We've had endless conversations about aliens and first contact--but what if a conversation with other intelligences is beyond our scope? Dr. Daniel Whiteson, particle physicist at CERN's Large Hadron Collider and professor at UC Irvine, joins us to explore less conventional thoughts on first contact. We look at the challenges of communicating with extraterrestrial intelligences, potential difficulties of communicating via non-terrestrial mathematics and physics, and the possibility that extraterrestrials might actually be terrestrial... but existing as denizens of the dark energy universe. One might be sitting in your lap right now! Join us for the far-ranging discussion. Headlines: Boeing's Troubled Starliner Spacecraft Faces Further Setbacks and Delays NASA Perseverance Rover Finds Promising Clues of Ancient Life on Mars NASA Space Telescope Faces Fiery Descent, Mission Planned to Save It Main Topic: Dark Matter, Particle Physics, and the Search for Extraterrestrial Intelligence UC Irvine's Dr. Daniel Whiteson Discusses Path into Space Science and Particle Physics Exploring Nontraditional Signals for Alien Communication Beyond Radio Waves The Mystery of Ultra-High Energy Particles and Speculation on Artificial Cosmic Rays Challenges of Detecting, Interpreting, and Interacting with Alien Intelligence Implications of Dark Matter for Hidden Civilizations and Parallel Existence Complexities in Communicating with Truly Alien Life and Human-Centric Scientific Assumptions Hosts: Rod Pyle and Tariq Malik Guest: Daniel Whiteson Download or subscribe to This Week in Space at https://twit.tv/shows/this-week-in-space. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit

Know the red flags of human traffickingWith the 2026 FIFA World Cup in the news, public safety agencies, anti-trafficking task forces, advocacy organizations, and media outlets are raising concerns about the potential for increased human trafficking activity surrounding a major international sporting event. Human trafficking remains a persistent danger in communities around the world, and is often closer to home than you'd think. In this episode, we sit down with Amanda Elkanick Oder of the Texas Advocacy Project to explore how banks and credit unions can help detect human trafficking and even support survivors as they rebuild their financial lives.Listen in to learn what key words and phrases frontline staff should be trained to investigate further, what challenges survivors of human trafficking face after leaving abusive situations, and how new payment rails are impacting the way human traffickers operate. Amanda also shares what training Texas Advocacy Project can offer financial institutions looking to shore up their communities against trafficking and how transaction data can also be an indicator of a financially abusive situation.About the guest:Amanda Elkanick Oder is the Chief Advocacy and Education Officer at Texas Advocacy Project, a statewide nonprofit law firm providing free legal and social services to survivors of domestic violence, sexual assault, stalking, and human trafficking. A nationally recognized leader in the movement to end abuse, Amanda brings over 20 years of experience in program development, public policy, and systems advocacy. She leads statewide training initiatives, advances legislative strategies, and builds enduring cross-sector partnerships to expand access to justice. Amanda regularly presents at national and statewide conferences and serves on multiple task forces focused on legal reform, systems advocacy, coordinated community response to violence, and maternal health equity.Helpful links:Texas Advocacy Project training and outreach resourcesThe FIFA World Cup and human trafficking: Know the red flagsHuman trafficking awareness webinar: Detecting, reporting, and partnering for survivors Human trafficking: Closer to home than you think  

Are you putting too much trust in your health and fitness tech? In this 5-Minute Check In, we ask: Can your smartwatch really detect AFib and is your ring accurately monitoring sleep? We're diving deep into the scientific data to reveal what these devices actually promise vs. what they actually deliver. Get the insights in just a few minutes.Guests: Dr. Thomas McGinn, SEVP and Chief Physician Executive Officer; Dr. Ankita Sagar, System VP Clinical Transformation and Well-Being; Dr. Phil Chang, Chief Medical and Quality Officer; and Brooke Burgess, System Director Clinical CommunicationsStudies: https://www.jacc.org/doi/10.1016/j.jacadv.2025.102133https://pubmed.ncbi.nlm.nih.gov/41230431/  

Join Dave and Adrian and possibly Donner chatting with Marcus from Regton Metal detectors on the new XP ICON and ICONX metal detectorsLearn more at www.bigdetectingshow.com or find us on YouTube, Facebook, Twitter, Instagram or TikTokSponsored by Metal Detecting NewsBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-big-detecting-show--3690873/support.

In this episode, host Frank La Vigne and his co-host Candace Gillhoolley sit down with Hillary Ogbodo, CTO of Almond Inc. and a passionate quantum researcher based in Nigeria. The conversation journeys from the challenges of fintech and credit systems in Africa, through Hillary's personal fascination with quantum teleportation, to the future of quantum encryption and security. They dive deep into quantum key distribution (QKD), real-world deployment hurdles, the fast-moving international race in quantum technology, and why the next five years could see QKD go from academic pilot to critical infrastructure. Whether you're a quantum novice or an aficionado, this episode unpacks the global implications of quantum security and what it means for industries from finance to defense—plus, some unexpected stories about cryptography, satellites, and the power of curiosity.LinksHilary on LinkedIn - https://www.linkedin.com/in/hillary-ogbodo-6352391b0/Watch on YouTube - https://www.youtube.com/watch?v=frJ9wtou-hsTime Stamps00:00 Fixing credit in Nigeria05:47 Explaining quantum data encryption09:01 Detecting eavesdroppers with error rates11:54 Discussing global quantum computing advancements15:34 Quantum computing secrecy16:41 Discussing QKD vs PQC algorithms21:56 Getting into cryptography after 200224:31 Getting into quantum computing27:26 Quantum teleportation research in China30:35 Rural broadband accessibility issues34:43 Wells Fargo tests quantum security39:32 Quantum key distribution advancements40:29 Discussing quantum resilient algorithms44:04 Discussing encryption with engineers

In this episode of The Egg Whisperer Show, I'm joined by Trudy McKanna, Senior Field Medical Director at GRAIL, to talk about a groundbreaking new test called Galleri®. This multi-cancer early detection test can identify signals of more than 50 different types of cancer through a simple blood draw, often before symptoms appear. For anyone focused on protecting their long-term health, identifying possible cancers early, and for those who have done treatment and may be concerned about future cancer risk, this technology could be life-changing. We talk about how the Galleri® test works, the science behind it, and what this means for cancer treatment and detection. Trudy also shares why early detection is so critical, how accurate the test is, and what healthcare providers and patients need to know about accessing this innovation. Read the full show notes on Dr. Aimee's site (with a transcript). In this episode, we cover: - What GRAIL's Galleri® test is and how it works - How early cancer detection offers more time and options for care, plus how it may help patients avoid chemo - Why the test could revolutionize preventative care and cancer treatment plans - What fertility specialists and patients should know about using Galleri® after Clomid usage - How GRAIL is working to expand access and education around early detection Find GRAIL's Galleri® test here: https://www.galleri.com/ Do you have questions about IVF? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, July 13, 2026, at 4 pm PST, where I'll explain IVF and Egg Freezing, and answer your questions live on Zoom. Other ways to connect with me: Visit my YouTube channel for more fertility tipsSubscribe to the newsletter to get updatesJoin Egg Whisperer SchoolRequest a Consultation with Dr. Aimee Dr. Aimee Eyvazzadeh is one of America's most well-known fertility doctors. Her success rate at baby-making gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

On today's show, we learn that healthcare providers say preventative care for women can lead to early treatment of breast cancer. Plus, we hear that this weekend's Juneteenth celebration in Fayetteville is the 30th consecutive year for the northwest Arkansas observation of the holiday. Plus, we offer a conversation about public libraries and public television in Arkansas.

Dr. Dan Ackerman and Dr. Reza Bavarsad Shahripour discuss the diagnostic performance of 4 major modalities: TCD, TTE, TEE, and cardiac CT in patients with embolic stroke of undetermined source.  Sho citation:  Read the related article in Neurology® Clinical Practice.     

Dr. Dan Ackerman talks with Dr. Reza Bavarsad Shahripour about the diagnostic performance of 4 major modalities: TCD, TTE, TEE, and cardiac CT in patients with embolic stroke of undetermined source.  Read the related article in Neurology® Clinical Practice.  Disclosures can be found at Neurology.org. 

As enterprises expand across multiple cloud environments, on-premise data centers, and dynamic AI workloads, traditional perimeter defenses and siloed cloud-native tools are no longer enough to secure the modern network. In this episode, Ashish sits down with Murali Rathinasamy, Senior Director of Product at Cisco, to break down the next evolution of network security: the Hybrid Mesh Firewall. Murali explains why relying solely on cloud-native firewalls can create visibility gaps, and how unified policy orchestration allows security teams to manage enforcement points seamlessly. He shares a real-world case study of how Multicloud Defense is used to eliminate manual route table configurations and achieve zero-downtime, blue-green upgrades. The conversation also tackles micro-segmentation. Murali breaks down why segmentation initiatives usually stall in "analysis paralysis" and provides a practical, agentless roadmap to reduce your attack surface "one bite at a time". Guest Socials -⁠⁠ ⁠⁠⁠Murali's LinkedinPodcast Twitter - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@CloudSecPod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠If you want to watch videos of this LIVE STREAMED episode and past episodes - Check out our other Cloud Security Social Channels:-⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Cloud Security Podcast- Youtube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Cloud Security Newsletter ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠If you are interested in AI Security, you can check out our sister podcast -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AI Security Podcast⁠Questions(00:00) Introduction(01:40) Murali Rathinasamy's Background and Role at Cisco(02:30) What is a Hybrid Mesh Firewall?(04:30) Bridging the Skills Gap: NetSec vs. CNAPP/CSPM(06:45) Case Study: Royal College of Surgeons in Ireland (RCSI)(09:40) The Limits of Cloud-Native Firewalls in a Multicloud World(13:30) Securing AI Workloads and Managing the Agent Blast Radius(15:40) Why You Need Unified Policy Orchestration Across Firewall Vendors(17:40) Why Micro-segmentation Fails: Overcoming Analysis Paralysis(24:45) How to Implement Micro-segmentation "One Bite at a Time"(31:30) Detecting and Blocking Prompt Injections with Cisco AI Defense(33:30) Where Does the Hybrid Mesh Firewall Fit in the Tech Stack?

Recognizing that osteoarthritis (OA) isn't just a disease of “old dogs” is transforming how veterinary professionals care for their canine patients. Yet, in the fast pace of clinical practice, performing a full orthopedic exam on every patient isn't always feasible. This episode of the VetFolio Voice podcast offers practical strategies to help you screen patients and identify those who would benefit most from a more thorough orthopedic evaluation. Learn how to communicate with clients on detecting early-onset OA, when to escalate to diagnostics, and how to tailor multimodal, long-term management strategies using a combination of NSAIDs, surgery and newer options—because every dog deserves to move comfortably at every stage of life.

Rebecca Hinds, author of "Your Best Meeting Ever" and Head of the Work AI Institute at Glean, breaks down the surprising findings from the new Work AI Index 2026 report surveying 6,000 workers. While 87% now use AI and report saving 13 hours per week, only 13% say their organization is performing significantly better—a paradox explained by two new concepts: "botsitting" (the hidden labor of making AI useful) and "botshitting" (delivering AI-generated work you can't defend). They discuss practical solutions including better-integrated AI systems, smarter AI detection policies, and aligning work to meaningful missions. LINKS: Rebecca Hinds Personal Website Glean Work AI Institute Your Best Meeting Ever Book Glean Enterprise AI Platform Stanford Future of Work Glean Enterprise Graph Pangram Labs AI Detection OpenAI ChatGPT Product Page Anthropic Claude Product Page Google Gemini Product Page Microsoft 365 Copilot Page Glean AI Transformation 100 Rebecca Hinds LinkedIn Profile Sponsor: Claude: Claude by Anthropic is an AI collaborator that understands your workflow and helps you tackle research, writing, coding, and organization with deep context. Get started with Claude and explore Claude Pro at https://claude.ai/tcr CHAPTERS: (00:00) About the Episode (03:22) Grounding AI adoption (06:46) Methodology and Glean (12:25) Productivity paradox emerges (Part 1) (20:31) Sponsor: Claude (22:22) Productivity paradox emerges (Part 2) (25:36) Bot sitting burden (34:00) Hidden time savings (39:56) Meaning versus automation (47:14) Enterprise graph potential (53:13) Detecting bot slop (01:00:32) Retention and incentives (01:07:54) Transformation and mission (01:20:06) AI teammate model (01:26:01) Future organizational design (01:32:31) Research and meetings (01:41:43) Episode Outro (01:45:07) Outro PRODUCED BY: https://aipodcast.ing

Maria chats with author Stacy Wilder whose books Liz Adams Mystery Series features Duke, a lie-detecting Lab! Stacy also donates a portion of the proceeds to wildlife conservation and the homeless--both people and pets. Check out her website for books, info, recipes (!) and more! storystacy.comSee omnystudio.com/listener for privacy information.

How do quantitative investors adapt when markets, technology and macro regimes are constantly changing? In this conversation, Alan Dunne sits down with George Patterson, CIO of PGIM Quant Solutions, to explore the evolution of systematic investing from the 1990s to today's AI driven landscape. They discuss regime detection, inflation risk, portfolio construction, machine learning, private markets, volatility overlays and the growing role of language models in investment research. George also shares insights from decades in quant investing, including lessons from Covid, the importance of model discipline and why communication skills matter as much as technical expertise.-----50 YEARS OF TREND FOLLOWING BOOK AND BEHIND-THE-SCENES VIDEO FOR ACCREDITED INVESTORS - CLICK HERE-----Follow Niels on Twitter, LinkedIn, YouTube or via the TTU website.IT's TRUE ? – most CIO's read 50+ books each year – get your FREE copy of the Ultimate Guide to the Best Investment Books ever written here.And you can get a free copy of my latest book “Ten Reasons to Add Trend Following to Your Portfolio” here.Learn more about the Trend Barometer here.Send your questions to info@toptradersunplugged.comAnd please share this episode with a like-minded friend and leave an honest Rating & Review on iTunes or Spotify so more people can discover the podcast.Follow Alan on Twitter.Follow George on LinkedIn.Episode TimeStamps: 00:00 - Introduction to George Patterson and his journey from physics to quantitative investing03:12 - Why multidisciplinary teams matter in modern quant investing04:13 - Inside PGIM Quant Solutions and the evolution of multi asset investing06:03 - How markets and macro investing have changed since the 1990s09:12 - The future of the 60/40 portfolio and institutional portfolio construction12:11 - Private markets, liquidity challenges and institutional investor concerns13:25 - Inflation, commodities and building modern inflation hedges19:33 - Detecting macro regimes using quantitative models23:26 - The hardest part of systematic investing: trusting the process27:00 - Covid, model failures and managing regime shifts in real time30:07 - Portfolio protection, options strategies and volatility overlays32:01 - How AI and large language models are transforming quantitative research40:02 - Fiscal risks, inflation concerns and the changing rate environment44:26 - Simplicity versus complexity in quantitative model design48:05 - Why markets evolve faster today and how models must adapt51:08 - Retail investors, meme stocks and market distortions53:33 - Emerging markets and where long term opportunities may exist55:08 - The future of quant investing and the limits of AI hype57:10 - George Patterson's career advice for aspiring quantsCopyright © 2025 – CMC AG – All Rights Reserved----PLUS: Whenever you're ready... here are 3 ways I can help you in your investment Journey:1. eBooks that cover key topics that you need to know about In my eBooks, I put together some key discoveries and things I have learnt during the more than 3 decades I have worked in the Trend Following industry, which I hope you will find useful. Click Here2. Daily Trend Barometer and Market Score One of the things I'm really proud of, is the fact that I have managed to published the Trend Barometer and Market Score each day for more than a decade...as these tools are really good at describing the environment for trend following managers as well as giving insights into the general positioning of a trend following strategy! Click Here3. Other Resources that can help youAnd if you are hungry for more useful resources from the trend following world...check out some precious resources that I have found over the years to be really valuable. Click HerePrivacy PolicyDisclaimer

CardioNerds (Dr. Billy-Joe Mullinax, Dr. Dinu Balanescu, and Dr. Jane Ehret) discuss risk stratification in acute pulmonary embolism with Dr. Stavros Konstantinides, Chair of the 2019 ESC Pulmonary Embolism Guidelines. Using a real-world case, this episode explores how modern PE care has moved beyond “massive” and “submassive” labels toward a dynamic, physiology-based approach. The discussion highlights the limitations of static risk scores, the importance of right ventricular dysfunction and biomarkers, and why normotension does not imply stability. Special emphasis is placed on intermediate-high risk PE, early identification of impending hemodynamic collapse, and the role of lactate, serial reassessment, and PERT teams in guiding escalation of care. Audio editing by CardioNerds intern, Joshua Khorsandi.The 2026 American multi-society PE guidelines were published after this episode was recorded. Dr. Dinu Balanescu and Dr. Billy-Joe Mullinax are Co-chairs for the CardioNerds PE Series, developed in collaboration with the PERT Consortium.   Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Pulmonary Embolism PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Stable blood pressure does not mean low risk in PEHypotension is a late finding. Patients may have severe RV failure, hypoxia, and tissue hypoperfusion while remaining normotensive — a key concept behind “normotensive shock.” Risk stratification in PE must be dynamic, not staticLegacy scores like PESI and Bova provide a snapshot and predict 30-day mortality, but they do not capture short-term trajectory or impending hemodynamic collapse. Intermediate-high risk PE is a dangerous and heterogeneous groupPatients with RV dysfunction, positive biomarkers, tachycardia, hypoxemia, and elevated lactate may have in-hospital mortality approaching 15%, rivaling STEMI. Lactate is a critical but underutilized marker in PEElevated lactate reflects tissue hypoxia and early circulatory failure and may identify patients at risk for collapse before blood pressure declines. PERT enables physiology-driven, patient-centered PE carePERT teams operationalize continuous reassessment, integrate imaging, labs, and clinical trajectory, and allow timely escalation — shifting PE management from rigid categories to real-time decision-making. Notes Drafted by Dr. Jane Ehret. 1. What is the contemporary framework for risk stratification in acute pulmonary embolism? Modern PE risk stratification prioritizes hemodynamics and right ventricular (RV) function rather than clot burden. The 2019 ESC Guidelines classify PE into high risk, intermediate risk (low vs high), and low risk, based on: Hemodynamic status, RV dysfunction on imaging, and Cardiac biomarkers. This framework emphasizes early mortality risk but requires clinical context to guide escalation decisions. 2. Why is normotension insufficient to define “stability” in PE? Blood pressure is a late marker of circulatory failure in PE. Patients can maintain normal BP through Tachycardia, Increased sympathetic tone, and RV compensation. Many patients with preserved BP may already have shock physiology, including hypoxemia, elevated lactate, and RV failure — sometimes referred to as “normotensive shock.” 3. How should intermediate-risk PE be conceptualized clinically? Intermediate-risk PE is heterogeneous, ranging from patients who do well on anticoagulation to those who deteriorate rapidly. Intermediate-high risk PE is defined by RV dysfunction on imaging and positive cardiac biomarkers. Clinical features such as tachycardia, increasing oxygen requirement, and elevated lactate identify patients at highest risk within this group. 4. What are the strengths and limitations of commonly used PE risk scores? Legacy scores are useful for initial risk categorization but are static and limited in predicting short-term deterioration. Most scores were developed to predict mortality or complications at fixed time points rather than dynamic clinical trajectory. 5. What are the commonly used risk scores and clinical tools in PE, and what is each designed to predict? ESC Risk Stratification Algorithm: Identifies high-risk PE by hemodynamics. Uses PESI or sPESI in normotensive patients to distinguish low-risk from non–low-risk PE. Uses RV dysfunction and biomarkers to differentiate intermediate-low from intermediate-high risk. Forms the basis of many institutional PE pathways. PESI and sPESI: Validated to predict 30-day mortality. Widely used to identify low-risk patients appropriate for outpatient management. Heavily influenced by age and comorbidities. Bova Score: Predicts 30-day PE-related complications in normotensive patients. Composite PE Shock Score (CPES): Predicts normotensive shock in hemodynamically stable PE patients. Pulmonary Embolism Progression (PEP) Score: Predicts progression from intermediate-risk to high-risk PE within 72 hours of diagnosis. PE Short-term Clinical Outcomes Risk Estimation (PE-SCORE): Predicts clinical deterioration or death within 5 days of PE diagnosis. Hestia Criteria: Identifies low-risk PE patients safe for outpatient treatment. Wells' Criteria and Revised Geneva Score: Determine pretest probability for diagnostic triage. PERC Score: Rules out PE in very low-risk patients. 6. What is the role of biomarkers in PE risk stratification? Troponin and natriuretic peptides reflect RV myocardial injury and strain. Current guidelines treat biomarkers as binary (positive vs negative), despite risk being continuous. Biomarkers are most helpful for: Initial risk classification. They are less useful for: Short-interval monitoring and Detecting rapid clinical deterioration. 7. Why is lactate an important physiologic marker in PE? Lactate reflects global tissue hypoxia and impaired perfusion. Elevated lactate may identify patients with: Early circulatory failure and Increased risk of imminent hemodynamic collapse. Lactate is not currently included in ESC risk algorithms but may add important prognostic information in intermediate-risk patients. 8. How does trajectory influence decision-making in PE management? Risk stratification should be viewed as a dynamic process, not a one-time label. Worsening clinical trajectory may include: Rising heart rate, Increasing oxygen needs, Rising lactate, and Progressive RV dysfunction. Serial reassessment is essential for timely escalation of care. 9. What role do Pulmonary Embolism Response Teams (PERT) play in risk stratification? PERT facilitates: Multidisciplinary decision-making and Integration of imaging, biomarkers, and clinical physiology. PERT is most valuable for: Intermediate-risk and high-risk PE and Patients with complex comorbidities or uncertain trajectory. PERT enables a shift from category-based to physiology-driven PE care. References 1. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019;54(3):1901647. Published 2019 Oct 9. doi:10.1183/13993003.01647-2019 2. Leidi A, Bex S, Righini M, Berner A, Grosgurin O, Marti C. Risk Stratification in Patients with Acute Pulmonary Embolism: Current Evidence and Perspectives. J Clin Med. 2022;11(9):2533. Published 2022 Apr 30. doi:10.3390/jcm11092533 3. Choi WH, Kwon SU, Jwa YJ, et al. The pulmonary embolism severity index in predicting the prognosis of patients with pulmonary embolism. Korean J Intern Med. 2009;24(2):123-127. doi:10.3904/kjim.2009.24.2.123 4. Jiménez D, Aujesky D, Moores L, et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010;170(15):1383-1389. doi:10.1001/archinternmed.2010.199 5. Chen X, Shao X, Zhang Y, et al. Assessment of the Bova score for risk stratification of acute normotensive pulmonary embolism: A systematic review and meta-analysis. Thromb Res. 2020;193:99-106. doi:10.1016/j.thromres.2020.05.047 6. Zhang RS, Yuriditsky E, Zhang P, et al. Composite Pulmonary Embolism Shock Score and Risk of Adverse Outcomes in Patients With Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(8):e014088. doi:10.1161/CIRCINTERVENTIONS.124.014088 7. Zhang RS, Alam U, Sharp ASP, et al. Validating the Composite Pulmonary Embolism Shock Score for Predicting Normotensive Shock in Intermediate-Risk Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(2):e013399. doi:10.1161/CIRCINTERVENTIONS.123.013399 8. Ehret J, Wakefield D, Badlam J, Antkowiak M, Erdreich B. Development of the Pulmonary Embolism Progression (PEP) score for predicting short-term clinical deterioration in intermediate-risk pulmonary embolism: a single-center retrospective study. J Thromb Thrombolysis. 2025;58(2):243-253. doi:10.1007/s11239-024-03051-5 9. Weekes AJ, Raper JD, Lupez K, et al. Development and validation of a prognostic tool: Pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE). PLoS One. 2021;16(11):e0260036. Published 2021 Nov 18. doi:10.1371/journal.pone.0260036 10. Zondag W, Hiddinga BI, Crobach MJ, et al. Hestia criteria can discriminate high- from low-risk patients with pulmonary embolism. Eur Respir J. 2013;41(3):588-592. doi:10.1183/09031936.00030412 11. Wells PS, Anderson DR, Rodger M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med. 2001;135(2):98-107. doi:10.7326/0003-4819-135-2-200107170-00010 12. Wolf SJ, McCubbin TR, Feldhaus KM, Faragher JP, Adcock DM. Prospective validation of Wells Criteria in the evaluation of patients with suspected pulmonary embolism. Ann Emerg Med. 2004;44(5):503-510. doi:10.1016/j.annemergmed.2004.04.002 13. Le Gal G, Righini M, Roy PM, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144(3):165-171. doi:10.7326/0003-4819-144-3-200602070-00004 14. Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost. 2004;2(8):1247-1255. doi:10.1111/j.1538-7836.2004.00790.x 15. Kline JA, Courtney DM, Kabrhel C, et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008;6(5):772-780. doi:10.1111/j.1538-7836.2008.02944.x

Retired Secret Service Brad Beeler goes behind the badge to reveal what it truly takes to protect the most powerful person on Earth, and what 25 years of high-stakes federal service teaches you about human nature, sacrifice, and the truth!!

Patricio Gallardo discusses the mysteries of dark matter and dark energy. He details future efforts to calibrate telescopes for detecting the "Axion" particle to understand the composition of the missing universe. (8/16)1920 SC

Up to 200 million people worldwide may be living with undiagnosed mild cognitive impairment – many unaware that early intervention could change their trajectory. In this episode, host Alex Maiersperger is joined by Marc Jones, CEO of Altoida, and Dr. Mona Flores of Altoida's Clinical Advisory Board to explore how AI and digital biomarkers are reshaping early detection of cognitive decline. Digital biomarkers register how the brain processes information, translating how brain networks function through the way we move, speak and remember. Altoida's platform tracks motor skills, speech complexity and memory recall, mapping them to data points to identify where brain function diverges from that of a healthy population. They also discuss how AI acts as a force multiplier, giving clinicians tools to spot trends, make informed decisions and spend more time with patients.

This episode provides practical advice on advanced SEO, AI engine optimization (AEO), answer engine optimization, technical website optimization, schema, and retention strategies for anyone looking to improve digital marketing visibility in the age of AI. Learn how to harness evolving platforms, implement the latest best practices, and create resilient, audience-focused web ecosystems.In this insightful episode, Favour Obasi-ike, MBA, MS dives deep into the evolution of SEO—comparing the foundations of "old" Search Engine Optimization with the demands and opportunities of "new" Search Everywhere Optimization.Listeners will uncover essential strategies for optimizing content across today's rapidly shifting digital environments, including website best practices, AI integrations, and the importance of technical SEO fundamentals.Favour explains how staying updated and proactive is vital, as algorithm changes and the rise of AI platforms like ChatGPT, Gemini, and others are reshaping the discovery and ranking of digital content. Favour also takes questions from the community, responding with real-world examples and tactical advice.Whether you're a business owner, marketer, content creator, or SEO professional, this episode offers actionable guidance for adapting to future-focused SEO. Listeners will learn why website speed, schema markup, secure protocols, and precise keyword versus prompt usage matter more than ever.Favour also discusses why attention and retention are the new KPIs, plus the growing importance of authority, expertise, and trust—in both human and AI-powered search.Who Is This For?Digital marketersBusiness owners and entrepreneursSEO professionalsContent creators and website managersAnyone seeking to future-proof their digital presenceReady to Rank? Book Your SEO & Web Dev Services Today

Danger of Libredtail https://isc.sans.edu/diary/Danger%20of%20Libredtail%20%5BGuest%20Diary%5D/32936 FreeBSD dhclient vulnerability https://www.freebsd.org/security/advisories/FreeBSD-SA-26:12.dhclient.asc Linux Copy-Fail Vulnerability CVE-2026-31431 https://copy.fail Bryan Nice Research Paper https://www.linkedin.com/in/bryannice/ https://www.sans.edu/cyber-research/detecting-ai-pickling

Warning, you'll hear a lie in this episode.  You won't be told it's a lie.  And 29% of those who listen probably won't spot the lie. But if you listen till the end, you'll learn the proven tips to spot lies like these.  Today on Nudge, Professor Richard Wiseman explains:  1) How to spot a liar  2) What makes someone lucky  3) If we're really separated by six connections  4) And why enlarged pupils made men buy books --- Richard's book Quirkology: https://amzn.to/4shYOJ6  Richard's book 59 Seconds: https://amzn.to/3Pf9pWI  Richard's SubStack: https://richardwiseman.substack.com/  Join 11,934 readers of the Nudge Newsletter: https://www.nudgepodcast.com/mailing-list Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/ --- Today's sources:  DePaulo, B. M., & Morris, W. L. (2004). Discerning lies from truths: Behavioural cues to deception and the indirect pathway of intuition. In P. A. Granhag & L. A. Strömwall (Eds.), The detection of deception in forensic contexts (pp. 15–40). Cambridge University Press. The Global Deception Research Team. (2006). A world of lies. Journal of Cross-Cultural Psychology, 37(1), 60–74. Milgram, S. (1967). The small-world problem. Psychology Today, 1, 61–67. Stewart, J. E., II. (1980). Defendant's attractiveness as a factor in the outcome of criminal trials: An observational study. Journal of Applied Social Psychology, 10(4), 348–361. Vrij, A. (2000). Detecting lies and deceit: The psychology of lying and the implications for professional practice. John Wiley & Sons. Wiseman, R. (1995). The Megalab truth test. Nature, 373, 391. Wiseman, R. (2003, June 4). It really is a small world that we live in. The Daily Telegraph, p. 16.

Many common heart tests detect damage after it occurs rather than predicting future risk. In this episode of The Natural Heart Doctor Show Podcast, Dr. Jack Wolfson explains why traditional cardiac testing falls short and shares advanced testing strategies—including oxidative stress measurement—to better assess heart attack and stroke risk.Assess your risk with an at-home urine test and expert review at ⁠heartattackrisktest.com⁠ to ensure it is not your turn to suffer from a heart attack.- - - - -About the Host:Dr. Jack Wolfson, DO, FACC, is a board-certified cardiologist and founder of Natural Heart Doctor. After more than two decades practicing cardiology, he shifted his focus toward prevention-centered heart care aimed at identifying risk before cardiac events occur.Through education and lifestyle-focused strategies, his work emphasizes nutrition, sleep, movement, environmental health, and proactive assessment designed to support long-term cardiovascular wellness.- - - - -Social Handles:Website: https://drjackwolfson.com/Website: https://naturalheartdoctor.com/LinkedIn: https://www.linkedin.com/in/drjackwolfsonReady to move past the confusion and fear of typical heart health approaches? Visit ⁠⁠naturalheartdoctor.com/discovery⁠⁠ to schedule your free discovery call and start your journey toward a 100-year heart with real, evidence-based answers.- - - - -PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.comhttps://drtalks.com/podcast-service/

For 50 years, the healthcare industry has been trying (and failing) to harness the power of artificial intelligence. It may finally be ready for prime time. What will this mean for human doctors — and the rest of us? (Part four of “The Freakonomics Radio Guide to Getting Better.”) SOURCES:Bob Wachter, professor, chair of the department of medicine at the University of California, San Francisco.Pierre Elias, cardiologist, assistant professor of biomedical informatics at Columbia University, medical director for artificial intelligence at NewYork-Presbyterian Hospital. RESOURCES:A Giant Leap: How AI Is Transforming Healthcare and What That Means for Our Future, by Bob Wachter (2026)."Epic Systems (MyChart)," by Acquired (2025)."Detecting structural heart disease from electrocardiograms using AI," by Pierre Elias and Timothy Poterucha (Nature, 2025)."What Are the Risks of Sharing Medical Records With ChatGPT?" by Maggie Astor (New York Times, 2025)."Will Generative Artificial Intelligence Deliver on Its Promise in Health Care?" by Bob Wachter and Erik Brynjolfsson (JAMA, 2023).The Digital Doctor: Hope, Hype, and Harm at the Dawn of Medicine's Computer Age, by Bob Wachter (2015). EXTRAS:"The Doctor Won't See You Now," by Freakonomics Radio (2025)."How to Stop Worrying and Love the Robot Apocalypse (Update)," by Freakonomics Radio (2024). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.