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Im Gespräch mit Moritz erklärt Dr. Peter Köppel, was Nukleotide sind und wie die Bausteine von DNA und RNA unsere ganz alltägliche Gesundheit beeinflussen. Natürlich gibt es auch Tipps, um die Nukleotid-Zufuhr zu verbessern.
TWiV re-issues our 100th episode which featured a discussion of viruses with David Baltimore, an exemplary scientist and Vincent's exemplary mentor, who passed on 6 September 2025. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: David Baltimore Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV David's early papers on poliovirus and mengovirus RNA synthesis Reverse transcriptase found by Baltimore and Temin (pdfs) Nobel Prize in Physiology or Medicine 1975 The David Baltimore asteroid belt Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
Audio roundup of selected biopharma industry content from Scrip over the business week ended September 5, 2025. In this episode: the US MASH market after Wegovy's approval; AstraZeneca and Mineralys in close hypertension race; United Therapeutics' Phase III win in IPF; Corsera aims to predict and prevent cardiovascular disease; and Ionis's RNA-targeted win in severe hypertriglyceridemia. https://insights.citeline.com/scrip/podcasts/scrips-five-must-know-things/quick-listen-scrips-five-must-know-things-RKP4E4CFGFGGXBRVXTI73V27U4/ This episode was produced with the help of AI text-to-voice and voice emulation tools. Playlist: soundcloud.com/citelinesounds/sets/scrips-five-must-know-things
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. Robert F. Kennedy Jr. faced the Senate Finance Committee in a tense hearing amidst calls for the removal of the health secretary. The committee questioned Kennedy on his recent actions, including the firing of CDC director Susan Monarez. Meanwhile, the FDA's new rare disease pathway received mixed reactions, with some questioning its tangible impacts. AC Immune downsized and refocused its pipeline, while Kennedy proposed adding seven new vaccine advisors to the ACIP. Other news included successful RNA editing in an AATD study, demands for YouTube to remove anti-vaccine videos, and a new framework for rare disease approvals by the FDA. Thank you for tuning in to today's episode of Pharma and Biotech daily.
In this episode of the Epigenetics Podcast, we talked with Arnau Sebé-Pedrós from the Center for Genomic Regulation in Barcelona about his work on chromatin evolution. The Interview starts by examining specific research findings, including his seminal 2018 paper demonstrating whole-organism single-cell transcriptomics to map larval and adult cell types in the model organism Nematostella vectensis. Dr. Sebe-Pedros recounted the challenges and triumphs faced when delving into single-cell studies of non-model organisms, revealing the innovative strategies employed in the lab to overcome these hurdles. Shifting gears, we touched upon his work comparing cell types and molecular pathways in reef-building corals through single-cell RNA sequencing, contributing to our understanding of evolutionary conservation and divergence within the cnidarian lineage. We discussed how this comparative approach not only adds to knowledge about coral biology but also enhances methodological frameworks in ecological studies. In addition, Dr. Sebe-Pedros shared insights into ongoing efforts to reconstruct eukaryotic chromatin evolution using comparative proteomics and genomics analysis, as well as the mechanisms of genomic regulation in various species. His reflections on the sharing of experimental insights across research groups illustrated the collaborative spirit prevalent in the scientific community, particularly regarding endeavors like the Biodiversity Cell Atlas consortium aimed at expanding single-cell efforts across the tree of life. The episode culminated with Dr. Sebe-Pedros's thoughts on the revolutionary impact of functional genomic technologies and the vast potential they hold for answering longstanding questions in evolutionary biology. With an emphasis on epigenetics, he defined this field as encompassing any information not encoded directly in the DNA, especially in its role in establishing cell identity and differentiation. References https://www.biodiversitycellatlas.org Sebé-Pedrós, A., Saudemont, B., Chomsky, E., Plessier, F., Mailhé, M. P., Renno, J., Loe-Mie, Y., Lifshitz, A., Mukamel, Z., Schmutz, S., Novault, S., Steinmetz, P. R. H., Spitz, F., Tanay, A., & Marlow, H. (2018). Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq. Cell, 173(6), 1520–1534.e20. https://doi.org/10.1016/j.cell.2018.05.019 Sebé-Pedrós, A., Chomsky, E., Pang, K., Lara-Astiaso, D., Gaiti, F., Mukamel, Z., Amit, I., Hejnol, A., Degnan, B. M., & Tanay, A. (2018). Early metazoan cell type diversity and the evolution of multicellular gene regulation. Nature ecology & evolution, 2(7), 1176–1188. https://doi.org/10.1038/s41559-018-0575-6 Kim, I.V., Navarrete, C., Grau-Bové, X. et al. Chromatin loops are an ancestral hallmark of the animal regulatory genome. Nature 642, 1097–1105 (2025). https://doi.org/10.1038/s41586-025-08960-w Related Episodes Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes) Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) Transposable Elements in Gene Regulation and Evolution (Marco Trizzino) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Cobertura do Fala Carlão para o Canal do Boi, direto da GreenLight Biosciences.Na entrevista, Areadne Zorzetto, Diretora de Marketing e Vendas da empresa, destacou o trabalho da GreenLight Biosciences, que tem o RNA como base de suas soluções, representando a nova fronteira no controle de pragas do agro.Ela explicou que os produtos são altamente específicos, desenvolvidos para combater pragas de forma direcionada, com eficácia comprovada e pegada ecológica sustentável, preservando o meio ambiente e atendendo às exigências de uma agricultura cada vez mais responsável.Entre as novidades, Areadne apresentou o Fortivance, ingrediente ativo recém-lançado no Brasil pela GreenLight, que potencializa a ação de inseticidas, garantindo mais eficiência no controle de pragas e ampliando os resultados no campo.Um bate-papo que mostra como a ciência e a inovação estão transformando o futuro do agro, com soluções modernas, eficazes e sustentáveis.
We returned from the Labor Day holiday to a spate of intriguing deals, including two that could surpass $2 billion: Vertex's new pact with Enlaza for autoimmune disease—which the Casgevy maker hopes could ease conditioning for the sickle cell/beta thalassemia gene therapy—and Novartis' agreement with Arrowhead for neurodegenerative diseases such as Parkinson's. But as we look ahead, Thursday's Senate Finance Committee will be the focus this week, as Health and Human Services Secretary Robert F. Kennedy Jr. will answer questions after the ousting of CDC Director Susan Monarez. Her departure is reportedly linked to changes to the regulation of COVID-19 vaccines, for which the FDA last week issued restricted approvals to Moderna, Pfizer/BioNTech and Novavax and rescinded the emergency use authorizations. The next ACIP meeting—where COVID-19 vaccines will be on the agenda—is set for Sept. 18 and 19. In the weight loss arena, Novo Nordisk presented results from a real-world study this weekend at the European Society of Cardiology Congress in Madrid showing that Wegovy cut the risk of heart attack, stroke or death by 57% compared to Eli Lilly's tirzepatide in people with obesity and cardiovascular disease. The company also continues to throw money into the space, last week inking a $550 million deal with Replicate for RNA-based treatments for obesity and diabetes. Meanwhile, Lilly is dropping studies of one oral obesity candidate as another nears a regulatory filing. Finally, the FDA greenlit the first GLP-1 generic for obesity. We also discuss reactions to the FDA's new guidance on radiopharma drug development, four recent approvals for rare diseases, and everything you ever wanted to know about SPACs.
Nessa cobertura do Fala Carlão para o Canal do Boi, Giuvan Lenz, Diretor de Desenvolvimento de Produtos da GreenLight Biosciences, contou sua trajetória profissional e destacou o trabalho da empresa, reconhecida como líder global no desenvolvimento de produtos à base de RNA.Ele explicou como essa tecnologia inovadora promete trazer soluções estratégicas para os desafios do campo, com destaque para produtos que em breve chegarão ao mercado. Entre eles, estão alternativas pensadas para a realidade tropical do Brasil, com uso simples e eficaz, voltadas a fortalecer a produção agrícola com sustentabilidade e eficiência.Com pesquisa de ponta e inovação aplicada, a GreenLight reforça seu compromisso de levar ao produtor soluções que unem ciência, praticidade e impacto positivo para o futuro do agronegócio.
What if your cows could tell you exactly what they need to thrive? That's the groundbreaking promise of epigenetics, where the frontier of dairy science meets practical farm management. In this fascinating deep dive, Ian Garner, Head of R&D at Antler Bio, reveals how gene expression technology is revolutionizing dairy farming by unlocking hidden potential beyond traditional genetics. While genetics provides the blueprint, epigenetics determines whether those genetic instructions are actually followed—and this can be influenced by everything from nutrition to environment.Through real-world examples, we discover how farms across Europe are seeing remarkable results by giving their cows a voice through RNA sequencing. One Finnish farm doubled milk production after implementing targeted changes, while most see a 7:1 return on investment within months. The beauty lies in the simplicity: sometimes it's as straightforward as adjusting vitamin supplementation or improving water trough placement based on what the cows' gene expression patterns reveal they truly need.We explore how this technology works practically on farm, from blood sampling to data analysis, and how the recommendations integrate with existing farm management systems. Beyond just boosting production, we discuss the potential for early disease detection, improved fertility, and enhanced animal welfare through preventative intervention based on expression patterns.For forward-thinking farmers looking to maximize performance and profitability, this episode offers a compelling glimpse into dairy farming's future—where understanding the language of gene expression might be the key to unlocking your herd's full potential. Ready to hear what your cows are trying to tell you?Send us a textFor more information about our podcast visit www.chewinthecud.com/podcast or follow us on Instagram @chewinthecudpodcast. ChewintheCud Ltd is also on Facebook & LinkedIn. You can email us directly at podcast@chewinthecud.com
Já imaginou usar RNA mensageiro para rejuvenescer a pele?Um estudo recente publicado na Nature Biomedical Engineering mostrou que vesículas extracelulares carregadas com RNA m podem estimular a produção de colágeno e reduzir rugas de forma duradoura!Então Vem Cienciar conosco!* Este episódio é uma parceria com o blog científico "Cientistas descobriram que". Visite o link e leia mais sobre a descoberta:https://cientistasdescobriramque.com/2025/04/02/a-evolucao-da-terapia-com-rna-mensageiro-tecnologia-avancada-para-o-rejuvenescimento-da-pele/#more-5822
Remixed- Path to KOLs: The New Chemist Podcast's Global Journey in Science, Pharma, and Education: Interview with Mohan Uttarwar, CEO & Co-Founder of 1Cell.Ai---In this episode we provide and educational episode remix made with software assistance ( for educational purposes only) , we sit down with Mohan Uttarwar, CEO & Co-Founder of 1Cell.Ai, to explore how AI-driven single-cell analytics are revolutionizing precision oncology. Discover how the OncoIncytes platform merges ctDNA, live CTCs, single-cell RNA and proteomics for a real-time, multimodal tumor profile—and learn how these insights are sharpening patient selection, accelerating ADC trials, and delivering earlier, more accurate measures of therapeutic response. Mohan also shares his playbook for building a capital-efficient biotech across Silicon Valley and India, the emerging trends set to reshape drug development, and practical advice for chemists, data scientists, and founders looking to break into the field. Tune in this August for a deep dive into the future of cancer research and drug discovery.--Please note: The views of this podcast represent those of my guest(s) and I, and do not constitute professional or medical advice or consultation. Please see a medical professional or healthcare professional for advice, suggestions and consultations. We disclaim any loss in any way.Music citation: Open source
Send us a textIn this episode of the Life Science Success Podcast my guest is Mark Stead, Head of Business Development at Atomic AI, a pioneering biotech company using artificial intelligence and structural biology to develop innovative RNA-targeted therapeutics. Mark brings over 12 years of experience in biotechnology, with a proven track record of negotiating high-value partnerships and driving strategic collaborations in drug discovery.00:00 Introduction to the Life Science Success Podcast00:30 Meet Mark Stead: Journey into Life Sciences03:26 Career Insights: From Amgen to Atomic AI11:20 Innovations at Atomic AI: Leveraging AI and Structural Biology19:37 The Future of AI in Drug Discovery31:03 Leadership and Personal Insights39:38 Conclusion and Farewell
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. CDC Director Monarez was fired after less than a month due to internal unrest over new COVID-19 vaccine policies. Novo Nordisk is investing over $500 million in RNA obesity treatments. The FDA has approved updated COVID-19 shots from Pfizer, Moderna, and Novavax with restrictions, causing concern among some groups. Prothena's Alzheimer's drug, PRX012, has shown high rates of brain swelling in Phase I testing. Novo Nordisk is collaborating with other companies on cardiometabolic treatments. The pharma industry is facing challenges and changes, with layoffs and restructurings occurring at various companies. Massachusetts has seen a decline in R&D and biomanufacturing jobs in 2024. Various webinars and events are being held to discuss topics such as pharma manufacturing and data accessibility. Job opportunities in the pharmaceutical industry include positions in business analysis, quality engineering, and project engineering.
The potential breakthrough in RNA vaccine technology has been increasingly discussed on social media. This episode looks at one promising study and its early, early results so far. UF GBM study: https://doi.org/10.1016/j.cell.2024.04.003 RNA Treatment Vaccine Review: https://doi.org/10.1002/ctm2.1384
On today's episode of The Ultimate Assist, John Stockton and Ken Ruettgers sit down with Dr. Brian Hooker, scientist, autism dad, and chief scientific officer at Children's Health Defense, for one of the most explosive interviews yet.Dr. Hooker recounts his son's devastating vaccine injury, his whistleblower role in exposing the CDC's suppression of autism data, and the 16-year nightmare his family endured in vaccine court—only to be denied justice. He unpacks conflicts of interest in vaccine research, the dangers of mercury and aluminum still in shots, and how studies are manipulated to hide the truth. From shedding and genetic susceptibility to Tylenol's hidden role in vaccine injury, Hooker explains what mainstream science refuses to discuss.He also reveals the inside story of testifying alongside Senator Ron Johnson, how Robert F. Kennedy Jr. is shaking up the health establishment, and why new self-amplifying RNA vaccines could be the biggest threat yet.
BUFFALO, NY — August 27, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 24, 2025, titled “RNA-binding protein AUF1 suppresses cellular senescence and glycolysis by targeting PDP2 and PGAM1 mRNAs.” In this study, Hyejin Mun, Chang Hoon Shin, Mercy Kim, Jeong Ho Chang, and Je-Hyun Yoon from the University of Oklahoma and Kyungpook National University investigated how changes in cellular metabolism contribute to aging. Their findings offer potential targets for therapies aimed at slowing or reducing the effects of aging. As cells age, they often lose their ability to divide and begin releasing harmful signals that damage nearby tissues. This process, called cellular senescence, is linked to many age-related diseases. A key feature of senescent cells is their altered metabolism, where they use more glucose and oxygen, even when oxygen levels are low. This leads to the production of inflammatory substances and fatty acids, which can accelerate tissue damage. The study examined how these metabolic changes are controlled at the molecular level. Researchers found that AUF1, a protein that binds to RNA, normally helps prevent aging by breaking down two enzymes involved in glucose metabolism: PGAM1 and PDP2. When AUF1 is missing or inactive, these enzymes build up. This causes the cell to produce more energy and inflammatory molecules, which are common features of senescent cells. “Our high throughput profiling of mRNAs and proteins from Human Diploid Fibroblasts (HDFs) revealed that the expression of pyruvate metabolic enzymes is inhibited by the anti-senescent RNA-binding protein (RBP) AUF1 (AU-binding Factor 1).” The team also identified another protein, MST1, which becomes active during cellular stress and aging. MST1 modifies AUF1 in a way that stops it from doing its protective job. As a result, PGAM1 and PDP2 accumulate, leading to faster aging of the cell. Experiments using human fibroblast cells and mouse models confirmed that higher levels of these enzymes are linked to stronger signs of cellular aging. These findings improve our understanding of how metabolism affects the aging process. They highlight the MST1-AUF1-PDP2/PGAM1 pathway as a key factor in the metabolic shift seen in aging cells. Since these enzymes and proteins are already known to be involved in other diseases, existing or future therapies might be used to block this pathway and reduce the effects of aging. This study offers a new direction for senotherapy—a field focused on treating or removing aging cells. By adjusting glucose metabolism through AUF1 and its targets, scientists believe it may be possible to slow aging or limit its effects on tissue function. More research is needed, but these insights could lead to new strategies for managing age-related diseases and promoting healthier aging. DOI - https://doi.org/10.18632/aging.206286 Corresponding authors - Jeong Ho Chang - jhcbio@knu.ac.kr, and Je-Hyun Yoon - jehyun-yoon@ouhsc.edu Video short - https://www.youtube.com/watch?v=Gbu6USUSkgg Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206286 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, AUF1, MST1, senescence, glycolysis To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.AbbVie has acquired Gilgamesh Pharmaceuticals for $1.2 billion, focusing on neurology and depression treatments. This move follows AbbVie's previous failure with Emraclidine in schizophrenia treatment. The biotech industry's IPO stalemate appears to be ending, with Lb Pharma planning an IPO to fund a phase III-ready schizophrenia asset. The FDA has pulled Valneva's chikungunya shot from the market due to safety concerns, and several obesity drugs have failed to make it to market. Meanwhile, Arnatar is working on advancing RNA therapies beyond silencing.In other news, the disappointment of oral obesity therapies is discussed, with Novo emerging as a leader in the field. Trials for Eli Lilly's Orforglipron and Viking Therapeutics' VK2735 were underwhelming, leading to increased interest in weight loss pills in low- and middle-income countries. Capricor Therapeutics plans to fight FDA rejection of its DMD cardiomyopathy treatment, while a study in JAMA contradicts claims of corruption in vaccine advisory committees. Updates on cancer, cell and gene therapy are also provided.Stay tuned for more updates and feel free to suggest topics for future coverage.
New Discovery Shakes Life's Origins: Proof of Intelligent Design? This eye-opening conversation uncovers the complexities of life's origin, scrutinizing the RNA world hypothesis against molecular biology's harsh realities. Experts Dr. Brian Miller and Dr. Casey Luskin join Lenny to discuss DNA-protein interdependence, polymerization challenges in water, and why self-organization doesn't explain life's emergence. With probabilistic hurdles in focus, they emphasize the need for a paradigm shift in scientific research to better address these fundamental questions.
Joe Untamed tackles two urgent battles shaping America's future: the rise of radical Islamist influence and the war over truth in public health. Robert Spencer, renowned scholar and director of Jihad Watch, joins us to break down the growing presence of Islamist ideology in U.S. communities—from mass gatherings in Michigan to city councils now dominated by Muslim politicians. What does this mean for American law, culture, and national security? Spencer peels the onion back on the elites enabling this transformation and warns what's at stake if we continue down this path unchecked. Then, Dr. Robert Malone—the original inventor of mRNA vaccine technology—returns to reveal how entrenched bureaucrats and Big Pharma allies are weaponizing science against the American people. With new developments inside HHS and RFK Jr.'s sweeping reforms, Malone exposes the deep state's retaliation, the dangers of indemnifying industries like RNA pesticides, and the long-term health consequences hidden from public view. From vaccine schedules to regulatory corruption, his insights strike at the heart of America's medical and political crises. Together, Spencer and Malone highlight the same underlying truth: powerful elites, whether in religion, government, or corporate boardrooms, are eroding American freedom from within. This is not just about foreign threats or public health—it's about the survival of liberty itself. Tonight's show is a wake-up call, offering clarity, urgency, and solutions for anyone ready to stand against the forces trying to reshape America in their image.
Jordan Sather and Nate Prince return with another hard-hitting episode of MAHA News, diving into the week's biggest health and freedom stories. They kick things off with the Pete and Bobby Challenge, where Pete Hegseth and RFK Jr. put their strength to the test in a push-up and pull-up competition that has everyone talking. From there, the hosts shift into the serious implications of glyphosate spraying in Canada and the broader dangers of genetically engineered crops, highlighting how hidden RNA tinkering in food could impact human genetics and health. The discussion then takes aim at the American Academy of Pediatrics, which is under fire for its push to remove vaccine exemptions and its continued cozy ties with big pharma giants like Pfizer, Merck, and Moderna. RFK Jr.'s sharp rebuke of the AAP sparks debate about liability, childhood vaccine schedules, and health freedom. With side conversations on raw milk legalization, natural detox strategies, and the cultural psyop of green lawns, this episode weaves humor, practicality, and blunt truth into an engaging exploration of health sovereignty.
Matters Microbial #104: Antibiotic “Tolerance” and Biofilms August 21, 2025 Today, Dr. Boo Shan Tseng, Associate Professor at the University of Nevada Las Vegas School of Life Sciences, joins the #QualityQuorum to discuss bacterial biofilms and antibiotic tolerance. Host: Mark O. Martin Guest: Boo Shan Tseng Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A video overview of biofilms. A comprehensive review article on biofilms. An article describing the impact biofilms have on disease. An article describing the impact of biofilms on implanted medical devices. A link to the Center for Biofilm Engineering at Montana State University that has MANY links of interest. An overview of biofilm development. An overview of confocal laser microscopy. Studying biofilms in flow cells. An article about the role proteins play in biofilm formation, which intersects with the Tseng group's research. The technique of single cell RNA seq. The technique of mRNA-FISH. An article about porins in bacteria, and how that can relate to antibiotic resistance. An article by Dr. Tseng and coworkers on the eDNA and biofilms discussed today. A lovely video of Dr. Tseng talking about the research she and her colleagues carry out in the laboratory. Dr. Tseng's biography from the American Society for Microbiology. Dr. Tseng's laboratory group website with wonderful links and images. Dr. Tseng's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
Hi friends! We're taking a much-needed August pause—we'll have new episodes for you in September. In the meanwhile, enjoy this pick from our archives! _____ [originally aired February 8, 2024] Where do memories live in the brain? If you've ever taken a neuroscience class, you probably learned that they're stored in our synapses, in the connections between our neurons. The basic idea is that, whenever we have an experience, the neurons involved fire together in time, and the synaptic connections between them get stronger. In this way, our memories for those experiences become minutely etched into our brains. This is what might be called the synaptic view of memory—it's the story you'll find in textbooks, and it's often treated as settled fact. But some reject this account entirely. The real storehouses of memory, they argue, lie elsewhere. My guest today is Dr. Sam Gershman. Sam is Professor of Psychology at Harvard University, and the director of the Computational Cognitive Neuroscience Lab there. In a recent paper, he marshals a wide-ranging critique of the synaptic view. He makes a compelling case that synapses can't be the whole story—that we also have to look inside the neurons themselves. Here, Sam and I first discuss the synaptic view and the evidence that seems to support it. We then talk about some of the problems with this classic picture. We consider, for example, cases where memories survive the radical destruction of synapses; and, more provocatively, cases where memories are formed in single-celled organisms that lack synapses altogether. We talk about the dissenting view, long lurking in the margins, that intracellular molecules like RNA could be the real storage sites of memory. Finally, we talk about Sam's new account—a synthesis that posits a role for both synapses and molecules. Along the way we touch on planaria and paramecia; spike-timing dependent plasticity; the patient H.M.; metamorphosis, hibernation, and memory transfer; the pioneering work of Beatrice Gelber; unfairly maligned ideas; and much, much more. Before we get to it, one important announcement: Applications are now open for the 2024 Diverse Intelligences Summer Institute (or DISI)! The event will be held in beautiful, seaside St Andrews, Scotland, from June 30 to July 20. If you like this show—if you like the conversations we have and the questions we ask—it's a safe bet that you'd like DISI. You can find more info at disi.org—that's disi.org. Review of applications will begin on Mar 1, so don't delay. Alright friends, on to my conversation about the biological basis of memory with Dr. Sam Gershman. Enjoy! Notes and links 4:00 - A general audience article on planarian memory transfer experiments and the scientist who conducted them, James V. McConnell. 8:00 - For more on Dr. Gershman's research and general approach, see his recent book and the publications on his lab website. 9:30 - A brief video explaining long-term potentiation. An overview of “Hebbian Learning.” The phrase “neurons that fire together wire together” was, contrary to widespread misattribution, coined by Dr. Carla Shatz here. 12:30 - The webpage of Dr. Jeremy Gunawardena, Associate Professor of Systems Biology at Harvard University. A recent paper from Dr. Gunawardena's lab on the avoidance behaviors exhibited by the single-celled organism Stentor (which vindicates some disputed, century-old findings). 14:00 - A recent paper by C. R. Gallistel describing some of his views on the biological basis of memory. 19:00 - The term “engram” refers to the physical trace of a memory. See recent reviews about the so-called search for the engram here, here, and here. 20:00 - An article on the importance of H.M. in neuroscience. 28:00 - A review about the phenomenon of spike-timing dependent plasticity. 33:00 - An article, co-authored by former guest Dr. Michael Levin, on the evidence for memory persistence despite radical remodeling of brain structures. See our episode with Dr. Levin here. 35:00 - A study reporting the persistence of memories in decapitated planarians. A popular article about these findings. 36:30 - An article reviewing one chapter in the memory transfer history. Another article reviewing evidence for “vertical” memory transfer (between generations). 39:00 - For more recent demonstrations of memory transfer, see here and here. 40:00 - A paper by Dr. Gershman, Dr. Gunawardena, and colleagues reconsidering the evidence for learning in single cells and describing the contributions of Dr. Beatrice Gelber. A general audience article about Gelber following the publication of the paper by Dr. Gershman and colleagues. 45:00 – A recent article arguing for the need to understand computation in single-celled organisms to understand how computation evolved more generally. 46:30 – Another study of classical conditioning in paramecia, led by Dr. Todd Hennessey. 49:00 – For more on plant signaling, see our recent episode with Dr. Paco Calvo and Dr. Natalie Lawrence. 56:00 – A recent article on “serial reversal learning” and its neuroscientific basis. 1:07:00 – A 2010 paper demonstrating a role for methylation in memory. Recommendations The Behavior of the Lower Organisms, by Herbert Spencer Jennings Memory and the Computational Brain, by C. R. Gallistel and Adam Philip King Wetware, by Dennis Bray Many Minds is a project of the Diverse Intelligences Summer Institute, which is made possible by a generous grant from the John Templeton Foundation to Indiana University. The show is hosted and produced by Kensy Cooperrider, with help from Assistant Producer Urte Laukaityte and with creative support from DISI Directors Erica Cartmill and Jacob Foster. Our artwork is by Ben Oldroyd. Our transcripts are created by Sarah Dopierala. Subscribe to Many Minds on Apple, Stitcher, Spotify, Pocket Casts, Google Play, or wherever you listen to podcasts. You can also now subscribe to the Many Minds newsletter here! We welcome your comments, questions, and suggestions. Feel free to email us at: manymindspodcast@gmail.com. For updates about the show, visit our website or follow us on Twitter (@ManyMindsPod) or Bluesky (@manymindspod.bsky.social).
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/popular-culture
Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.## Viking Therapeutics' oral obesity pill, VK2735, achieved over 12% weight loss in a clinical trial, causing their stock to plummet due to safety concerns. The pending approval of oral Wegovy has also brought attention to high-dose peptides.## Meanwhile, leaked information reveals a proposed overhaul of vaccine strategies and access to novel therapies. The FDA rejected PTC Therapeutics' drug for Friedreich's ataxia, and Novo Nordisk reassured investors of their capacity to supply oral semaglutide. Fedegari now offers customized solutions for the pharmaceutical industry, and Vantai is in talks with Halda for a potential proteomics partnership. ## Other news includes conflicts of interest in vaccine committees declining, RegenxBio facing a delay in their gene therapy approval, and Genentech ending a partnership with Adaptive Biotechnologies. Kriya raises $313 million for gene therapy, Merck KGaA invests in RNA-targeting technology, and Novo Nordisk receives approval for Wegovy.
In this Mol Bio Minutes mini-episode, Thermo Fisher Scientific's Agnė Žiupkaitė takes listeners on a journey through the evolving world of RNA assay development—focusing specifically on 1-Step RT-qPCR. She outlines the critical considerations for assay developers, including enzyme speed, robustness, and the growing demand for customizable reagents that meet both technical and regulatory needs.Highlighting Thermo Fisher's SuperScript reverse transcriptase family—particularly the Lyo-ready SuperScript III Flash RT—Agnė explains how innovations in enzyme design have broken past bottlenecks in assay workflow, enabling reverse transcription in under a minute. She also explores the power of customization, from labeling and fill formats to enzyme formulation changes and glycerol-free options that support microfluidic platforms and lyophilization.Agnė offers practical insight into how raw material suppliers can serve as collaborative partners, not just vendors. She emphasizes the importance of commercial rights, scalability, and regulatory readiness when sourcing components for commercial assay kits. Whether you're an OEM kit developer or a scientist building the next molecular breakthrough, this episode is packed with actionable insights to improve efficiency, reliability, and speed.Helpful resource links mentioned in this episode:Learn more about raw materials for molecular diagnosticsOrder Lyo-ready SuperScript III Flash TranscriptaseVisit this page to expand your knowledge of reverse transcription Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. Novo Nordisk's drug Wegovy has received approval for label expansion, potentially boosting its market performance. Tonix has also secured approval for a new fibromyalgia medication. Additionally, Novo has teamed up with GoodRx to provide lower prices for its drugs. Merck KGaA has made a significant investment of $2 billion in RNA-targeting technology through a collaboration with Skyhawk Therapeutics. On the sterilization front, Fedegari now offers tailored solutions for the pharmaceutical sector. In other updates, Pfizer's sickle cell therapy did not succeed in Phase III trials, while gene therapy company Kriya has raised an impressive $313 million. Kennedy has shown support for mRNA vaccines in cancer treatment. Bausch Health has closed a facility, Precigen has received FDA approval for an immunotherapy drug, and Eli Lilly has partnered with Superluminal in the obesity pipeline. Stay tuned for more industry news and developments.
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
Get Your SUPER-SUPPLIMENTS HERE: https://vni.life/wam Use Code WAM15 & Save 15%! Life changing formulas you can't find anywhere else! DITCH YOUR DOCTOR! https://www.livelongerformula.com/wam Get a natural health practitioner and work with Christian Yordanov! Mention WAM and get a FREE masterclass! You will ALSO get a FREE metabolic function assessment! GET YOUR APRICOT SEEDS at the life-saving Richardson Nutritional Center HERE: https://rncstore.com/r?id=bg8qc1 Use code JOSH to save money! GET YOUR WAV WATCH HERE: https://buy.wavwatch.com/WAM Use Code WAM to save $100 and purchase amazing healing frequency technology! Josh Sigurdson reports on the push for the new Plandemic 2.0 as Bill Gates releases GMO mosquitoes and by "coincidence" we see a historic mosquito caused dengue outbreak hit the news. We are seeing a lot of fear mongering surrounding mosquito caused illnesses right now including Chikungungya Virus which lead to cities bringing in Covid style lockdowns in China as we recently reported. With drones fogging the skies, the previously banned Chikungungya vaccines are back on the table with restrictions lifted. It also so happens that the government has a program where they can secretly inject people by releasing mosquitoes called "flying syringes" which can "vaccinate" people utilizing their saliva. There has also been a push to release vaccine dental floss as well as spray the food supply with mRNA by Moderna. To top it all off, the largest pandemic exercise ever is scheduled for this autumn, called Exercise Pegasus. With Bird Flu propaganda and continued pushes to fast track self amplifying RNA technology, it's pretty obvious this mosquito normalization campaign could end in another pandemic hoax leading to further poisoning of the masses. Be mentally and physically vigilant in the face of it! Stay tuned for more from WAM! HELP SUPPORT US AS WE DOCUMENT HISTORY HERE: https://gogetfunding.com/help-keep-wam-alive/# GET NON-MRNA FREEZE DRIED MEAT HERE: https://wambeef.com/ Use code WAMBEEF to save 20%! GET HEIRLOOM SEEDS & NON GMO SURVIVAL FOOD HERE: https://heavensharvest.com/ USE Code WAM to save 5% plus free shipping! Get local, healthy, pasture raised meat delivered to your door here: https://wildpastures.com/promos/save-20-for-life/bonus15?oid=6&affid=321 USE THE LINK & get 20% off for life and $15 off your first box! BUY GOLD HERE: https://firstnationalbullion.com/schedule-consult/ PayPal: ancientwonderstelevision@gmail.com FIND OUR CoinTree page here: https://cointr.ee/joshsigurdson PURCHASE MERECHANDISE HERE: https://world-alternative-media.creator-spring.com/ JOIN US on SubscribeStar here: https://www.subscribestar.com/world-alternative-media For subscriber only content! Pledge here! Just a dollar a month can help us alive! https://www.patreon.com/user?u=2652072&ty=h&u=2652072 BITCOIN ADDRESS: 18d1WEnYYhBRgZVbeyLr6UfiJhrQygcgNU World Alternative Media 2025
The United States Department of Health and Human Services recently announced that it would cancel nearly USD 500 million of funding for mRNA vaccine projects. The reason, Health Secretary Robert F. Kennedy Jr. said, was safety and efficacy concerns.mRNA or messenger RNA vaccines hit the news during the Covid-19 pandemic when the world was desperately trying to create vaccines in order to save lives. mRNA vaccines for Covid were developed rapidly, given to thousands of people and are believed to have saved numerous lives.Like all vaccines that we have today, rare cases of adverse effects are possible – but the benefits, say experts far outweigh the risks.How are mRNA vaccines different from the others we have? How effective and safe are they? Can they help with other diseases as well? And what does the cut in funding mean for vaccine development and research worldwide? Guest: Dr Anurag Agrawal, Dean, BioSciences and Health Research, Trivedi School of Biosciences at Ashoka University Host: Zubeda Hamid Edited by Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices
BUFFALO, NY – August 15, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 13, 2025, titled “Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.” In this study, first authors Valeriy Domenyuk and Kasey Benson, along with corresponding author David Spetzler from Caris Life Sciences in Irving, Texas, introduce MI Cancer Seek, an FDA-approved test designed to deliver comprehensive tumor profiling. MI Cancer Seek demonstrated strong concordance with other FDA-approved companion diagnostics and serves as a powerful tool to guide treatment decisions in both adult and pediatric cancer patients. Cancer remains one of the most complex and diverse diseases to treat. With many targeted therapies currently FDA-approved, selecting the right one for a specific patient requires detailed genetic insights. MI Cancer Seek addresses this need by analyzing both DNA and RNA from a single tumor sample. The tool identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers. One of the most significant strengths of MI Cancer Seek is its ability to deliver accurate and reliable results from minimal tissue input (50 ng). Even when analyzing formalin-fixed paraffin-embedded samples, which are widely used but often degraded, the test maintained high levels of accuracy. It successfully detected important genetic alterations such as PIK3CA, EGFR, BRAF, and KRAS/NRAS mutations and measured tumor mutational burden (TMB) and microsatellite instability (MSI), both of which are key indicators for immunotherapy response. In clinical comparisons, the test achieved over 97% agreement with other FDA-approved diagnostic tools, confirming its reliability in detecting critical biomarkers. Notably, it showed near-perfect accuracy in identifying MSI status in colorectal and endometrial cancers. The researchers also demonstrated that the test maintains precision across different lab conditions and varying DNA input levels, confirming its robustness for routine clinical use. Beyond its role as a companion diagnostic, MI Cancer Seek incorporates additional features developed under its predecessor, MI Tumor Seek Hybrid. These include detection of homologous recombination deficiency, structural variants, and cancer-related viruses. It also includes advanced tools such as the Genomic Probability Score for identifying the tissue of origin in cancers of unknown primary, as well as a gene signature to guide first-line chemotherapy in colorectal cancer. “One limitation to be considered is the low PPA for ERBB2 CNA detection.” By offering deeper genetic insights from a single, small sample, MI Cancer Seek has the potential to streamline diagnostics, reduce testing costs, and connect patients to effective therapies more quickly. As precision medicine continues to expand, this assay stands out as a comprehensive and efficient solution for meeting the evolving needs of modern oncology. DOI - https://doi.org/10.18632/oncotarget.28761 Correspondence to - David Spetzler - dspetzler@carisls.com Video short - https://www.youtube.com/watch?v=D4hd2FxCYY8 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/postsDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAEmail: info.fromthespectrum@gmail.com
HHS Director Robert F. Kennedy, Jr declared on Friday, August 8, 2024 the CDC and HHS will suspend the use of mRNA vaccines for COVID-19 treatment, and restrict its use in future vaccines due to components that trun RNA into DNA, making the vaccines highly ineffective as well as potentially dangerous.In this short clip. Mr. Kennedy outlines his reasonings and what the Deaprtment and health researchers have discovered thus far since the implementation of mRNAwas introduced four years ago as a therapy for treating coronavirus.
Send us a textIn this episode of the Life Science Success Podcast my guest is John Schmitt, a military veteran, entrepreneur, and Co-Founder & CEO of iXpressGenes who is leveraging innovative RNA biomarker technologies to revolutionize trauma screening in healthcare. With over 20 years of leadership experience in the U.S. Army and a Master's degree in Microbiology and Immunology, John is dedicated to developing data-driven solutions for early detection and prevention of trauma-related diseases.00:00 Introduction and Podcast Overview01:02 Welcoming the Guest: John Schmitt02:00 John Schmitt's Journey to Biotechnology05:58 Military Experience and Leadership Insights13:09 Founding iXpressGenes: The Origin Story17:31 Mission and Objectives of iXpressGenes23:08 Challenges and Innovations in Biomarker Technologies27:42 Personal Leadership and Inspirations35:00 Conclusion and Podcast Wrap-Up
On todays show AI models, quantum computing, mental health, smartphones, cryptocurrency, Tesla, regenerative braking, oil reserves, wind energy, military applications, open source, electric vehicles, hologram technology, parenting, cybersecurity., Energy transition, nuclear power, fusion, hydrocarbons, solar energy, wind energy, material science, AI, tariffs, manufacturing, redistricting, RNA vaccines, youth violence, Trump, China. Have Fun
In this episode of the Epigenetics Podcast, we talked with Erica Korb from the University of Pennsylvania about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. Dr. Korb discusses the focus of her lab, which centers on epigenetic mechanisms impacting gene regulation in neurons. Her research primarily examines histone biology and its connection to neurodevelopmental disorders, including autism spectrum disorder and intellectual disabilities. Dr. Korb expounds on the collaborative environment at UPenn's Epigenetics Institute, emphasizing how the rich diversity of research topics fosters innovative ideas and projects within the community. Reflecting on her earlier work from her postdoctoral studies, Dr. Korb discusses her first significant findings regarding the protein BRD4. This work demonstrated BRD4's role in mediating transcriptional regulation crucial for learning and memory processes. She explains how disrupting this protein's function in neurons hindered critical gene activations required for memory formation in mice. This foundational understanding opened avenues for exploring the broader implications of chromatin regulation in various neurodevelopmental conditions. Transitioning into her current research endeavors, Dr. Korb reveals how she aims to expand her focus beyond Fragile X syndrome. With her lab now investigating multiple chromatin regulators implicated in various forms of autism spectrum disorders, she describes a recent project where RNA sequencing exposed substantial overlaps in gene expression changes associated with five distinct chromatin modifiers, each contributing uniquely to neuronal function while collectively demonstrating sensitivity to chromatin disruptions. A significant portion of the discussion centers around Dr. Korb's unexpected exploration into how COVID-19 intersects with chromatin biology through a phenomenon known as histone mimicry. Leveraging bioinformatic tools during the pandemic, her lab discovered that certain viral proteins mimic histone sequences, which may lead to altered transcriptional outputs in host cells. This coincidental finding illustrates both the creative adaptability needed in scientific research and the importance of collaborative efforts across disciplines to uncover new insights. The conversation also delves into Dr. Korb's recent work regarding the histone variant H2BE, initiated by one of her graduate students. She explains how prior research only recognized H2BE's expression in the olfactory system, yet her lab has demonstrated its significant role in regulating synaptic genes and memory formation throughout broader neuronal contexts. Notably, they identified a single amino acid change that influences H2BE's function in chromatin accessibility and gene transcription, emphasizing its potential evolutionary conservation across species. In terms of H2BE's role, Dr. Korb elucidates that its activity is integral in response to extracellular stimuli, particularly within the context of neuronal activation. Intriguingly, they found that H2BE expression decreases in reaction to long-term neuronal stimulation, suggesting a complex mechanism of homeostatic plasticity crucial for regulating neuronal activity levels. This research not only advances understanding of chromatin dynamics but also holds implications for neuronal health and disease mechanisms. References Feierman, E. R., Louzon, S., Prescott, N. A., Biaco, T., Gao, Q., Qiu, Q., Choi, K., Palozola, K. C., Voss, A. J., Mehta, S. D., Quaye, C. N., Lynch, K. T., Fuccillo, M. V., Wu, H., David, Y., & Korb, E. (2024). Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Molecular cell, 84(15), 2822–2837.e11. https://doi.org/10.1016/j.molcel.2024.06.025 Korb, E., Herre, M., Zucker-Scharff, I., Gresack, J., Allis, C. D., & Darnell, R. B. (2017). Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell, 170(6), 1209–1223.e20. https://doi.org/10.1016/j.cell.2017.07.033 Kee, J., Thudium, S., Renner, D. M., Glastad, K., Palozola, K., Zhang, Z., Li, Y., Lan, Y., Cesare, J., Poleshko, A., Kiseleva, A. A., Truitt, R., Cardenas-Diaz, F. L., Zhang, X., Xie, X., Kotton, D. N., Alysandratos, K. D., Epstein, J. A., Shi, P. Y., Yang, W., … Korb, E. (2022). SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature, 610(7931), 381–388. https://doi.org/10.1038/s41586-022-05282-z Feierman, E. R., Paranjapye, A., Su, S., Qiu, Q., Wu, H., & Korb, E. (2024). Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling. bioRxiv : the preprint server for biology, 2024.11.01.620920. https://doi.org/10.1101/2024.11.01.620920 Related Episodes Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats) The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
RFK Jr. Halts $500 Million In mRNA Vaccine Funding, Says Technology Prolonged COVID-19 By Encouraging New Mutations
Congressman Ralph Norman, who is now a candidate for governor of South Carolina, shares his motivations for transitioning from Congress to the gubernatorial race and discusses his vision for the state, including infrastructure improvements, term limits, and combating corruption. Congressman Norman also reflects on the successes of Florida under Governor Ron DeSantis and the need for South Carolina to adopt similar strategies. Dr. Peter McCullough, chief scientific officer at The Wellness Company, discusses the potential links between COVID-19 vaccines and the increase in rapid cancer cases. We explore the implications of messenger RNA technology, the influence of pharmaceutical advertising on medical reporting, and the emerging role of Ivermectin in cancer research. Aaron Withe, CEO of the Freedom Foundation, reveals the troubling trends stemming from the significant influence of teachers unions on American culture and politics. Kasim Khan takes a closer look at the dire situation of his father, former Pakistani Prime Minister Imran Khan, who has been imprisoned under disturbing conditions. Khan shares the harrowing details of his father's incarceration, the struggle for human rights, and the international efforts to secure his release. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
01:00:36 – Danish Study Reversal: Autism Link ConfirmedA Danish vaccine safety study is quietly corrected to reveal a correlation between aluminum and autism—but the researchers refuse media interviews, triggering accusations of deception. 01:13:42 – Gulf Jab Syndrome and COVID InjuriesThe show draws chilling comparisons between unexplained Gulf War illnesses and post-COVID vaccine injuries—calling both the results of reckless, untraceable experimentation. 01:19:36 – Religious Exemptions Under AttackPediatric elites urge the removal of all non-medical vaccine exemptions. The host argues that this represents a merging of medicine and state tyranny. 01:21:08 – The Blasphemy of “Redeemed” Fetal CellsReligious leaders are condemned for claiming vaccines developed with aborted fetal cells are morally acceptable. The host calls this a spiritual betrayal. 01:26:20 – RNA-Sprayed Food: Next Bioengineering ThreatA Moderna spin-off develops RNA pesticides that replicate in crops. The host warns this could embed genetic manipulation directly into the food supply. 02:27:34 – Cops Blame Social Media, Not AttackersThe Cincinnati police chief says social media made the mob beating "look worse than it was." The show mocks this excuse and blasts bystanders for doing nothing while a man was brutally attacked. 02:37:21 – Diversity Doesn't Stop TyrannyCincinnati's first female police chief faces lawsuits for discriminating against white men. The host mocks DEI hires as superficial fixes that don't change the abusive nature of policing. 02:44:26 – UK Internet Crackdown Triggers VPN SurgeBritish citizens scramble for VPNs as the government rolls out harsh age-verification laws. The segment warns that it's less about child safety and more about censorship and digital control. 02:50:10 – Online Safety Act Instantly Used for CensorshipJust hours after going live, the UK law is used to suppress anti-immigration protests. The host says this proves the law was never about safety—just silencing dissent. 02:54:51 – Eric Peters Returns“My first guest as I come back… is Eric Peters… somebody I really respect, who really gets it.” 03:03:02 – Destroy Trust in Institutions“I'm here to destroy trust in institutions. That's my life mission…”Peters declares that blind faith in government institutions must be dismantled—not restored. 03:20:08 – Masculinity, Compliance & Modern MenDiscussion on emasculation, symbolic submission, and how modern clothing and behavior reflect cultural decline. Jordan Peterson is referenced. 03:47:28 – Hidden Worldview in Media“Very subtle philosophy… if you just accept it without looking critically…”Hollywood and media messaging are described as covert tools of cultural transformation. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
01:00:36 – Danish Study Reversal: Autism Link ConfirmedA Danish vaccine safety study is quietly corrected to reveal a correlation between aluminum and autism—but the researchers refuse media interviews, triggering accusations of deception. 01:13:42 – Gulf Jab Syndrome and COVID InjuriesThe show draws chilling comparisons between unexplained Gulf War illnesses and post-COVID vaccine injuries—calling both the results of reckless, untraceable experimentation. 01:19:36 – Religious Exemptions Under AttackPediatric elites urge the removal of all non-medical vaccine exemptions. The host argues that this represents a merging of medicine and state tyranny. 01:21:08 – The Blasphemy of “Redeemed” Fetal CellsReligious leaders are condemned for claiming vaccines developed with aborted fetal cells are morally acceptable. The host calls this a spiritual betrayal. 01:26:20 – RNA-Sprayed Food: Next Bioengineering ThreatA Moderna spin-off develops RNA pesticides that replicate in crops. The host warns this could embed genetic manipulation directly into the food supply. 02:27:34 – Cops Blame Social Media, Not AttackersThe Cincinnati police chief says social media made the mob beating "look worse than it was." The show mocks this excuse and blasts bystanders for doing nothing while a man was brutally attacked. 02:37:21 – Diversity Doesn't Stop TyrannyCincinnati's first female police chief faces lawsuits for discriminating against white men. The host mocks DEI hires as superficial fixes that don't change the abusive nature of policing. 02:44:26 – UK Internet Crackdown Triggers VPN SurgeBritish citizens scramble for VPNs as the government rolls out harsh age-verification laws. The segment warns that it's less about child safety and more about censorship and digital control. 02:50:10 – Online Safety Act Instantly Used for CensorshipJust hours after going live, the UK law is used to suppress anti-immigration protests. The host says this proves the law was never about safety—just silencing dissent. 02:54:51 – Eric Peters Returns“My first guest as I come back… is Eric Peters… somebody I really respect, who really gets it.” 03:03:02 – Destroy Trust in Institutions“I'm here to destroy trust in institutions. That's my life mission…”Peters declares that blind faith in government institutions must be dismantled—not restored. 03:20:08 – Masculinity, Compliance & Modern MenDiscussion on emasculation, symbolic submission, and how modern clothing and behavior reflect cultural decline. Jordan Peterson is referenced. 03:47:28 – Hidden Worldview in Media“Very subtle philosophy… if you just accept it without looking critically…”Hollywood and media messaging are described as covert tools of cultural transformation. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
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