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Zakalený vzhled piva souvisí s kombinací proteinů z ječmene a polyfenolů z chmele. Když vědci přidali do ležáků extrakt z kvasinek navíc, pivo se nesrazilo. Roli v tom hraje spojení proteinů a kvasinkové RNA.
Impact Video Ministries explains to us how we can know that god is real, and they are mostly length based reasons.Cards:Fact-Checking James Tour's Embarrassing Debate Performance:www.youtube.com/watch?v=YAm2W99Qm0oGod's "Perfect" Word has a LOT of Imperfections…:https://www.youtube.com/watch?v=_TVKrUWbvXQDesigns Need Designers, so EVERYTHING Is Designed!: https://www.youtube.com/watch?v=hPDm77oAXXUOriginal Video: https://tinyurl.com/2cyaq6djSources:Neutrino detector: https://tinyurl.com/hwlcvcqAbiogenesis through gradual evolution of autocatalysis into template-based replication: https://tinyurl.com/2359v3qaIdentifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites: https://tinyurl.com/yyqbrajwLife as a manifestation of the second law of thermodynamics: https://tinyurl.com/29fqxpgsOrganic Synthesis via Irradiation and Warming of Ice Grains in the Solar Nebula: https://tinyurl.com/262ln3vyOrigin and evolution of the genetic code: the universal enigma: https://tinyurl.com/28fp5xu4Spontaneous formation and base pairing of plausible prebiotic nucleotides in water: https://tinyurl.com/2c2n655rSpontaneous network formation among cooperative RNA replicators: https://tinyurl.com/ycwk6s3rThe Genetics of Vitamin C Loss in Vertebrates: https://tinyurl.com/224hum2aWhere did bone come from? An overview of its evolution: https://tinyurl.com/24w9azexThe human cell count and size distribution: https://tinyurl.com/2d2qsq3lWhat is the Most Recent Manuscript Count for the New Testament?: https://tinyurl.com/28kcvamgAll my various links can be found here:http://links.vicedrhino.comThis content is CAN credentialed, which means you can report instances of harassment, abuse, or other harm on their hotline at (617) 249-4255, or on their website at creatoraccountabilitynetwork.orgBecome a supporter of this podcast: https://www.spreaker.com/podcast/viced-rhino-the-podcast--4623273/support.
In this episode of the Epigenetics Podcast, we talked with Mo Motamedi from the Center for Cancer Research at Massachusetts General Hospital about his work on RNA-mediated epigenetic regulation. The Interview starts with Dr. Motamedi sharing his personal journey into the realm of biology, sparked by a familial inclination towards science and a challenge to excel in a field that initially felt daunting. His passion was ignited during a genetics class, as he recognized the quantitative nature of the discipline amidst the evolution of modern techniques like qPCR and high-throughput sequencing. Dr. Motamedi goes on to articulate the importance of understanding the interplay between genetics and broader biological systems, emphasizing that an insightful grasp of evolution is vital for decoding cellular mechanisms. He reflects on his time in a postdoctoral lab under Danish Moazet, investigating RNA interference (RNAi) and its unexpected nuclear roles, contributing significantly to the understanding of how RNAi is involved in gene silencing via chromatin interaction. As his narrative unfolds, Dr. Motamedi provides deep insights into his own lab's work, which focuses on the establishment and maintenance of epigenetic states and their implications in cancer epigenetics. He discusses groundbreaking discoveries related to RNAi and heterochromatin, detailing experiments that unveil how specific proteins contribute to transcriptional and post-transcriptional gene silencing. A pivotal theme emerges: the complex dynamics of genome evolution and chromatin organization can be reshaped under various biological contexts, including the quiescent state of cells under stress. Moreover, the discussion traverses recent publications from Dr. Motamedi's lab, revealing how they identify long non-coding RNAs that function as silencers at centromeres, an essential mechanism that aids in the establishment of heterochromatin independently of RNAi. His findings advocate for the idea that well-structured genome organization can lead to more efficient gene regulation, which can also be crucial in therapeutic contexts for various cancers. References Motamedi, M. R., Hong, E. J., Li, X., Gerber, S., Denison, C., Gygi, S., & Moazed, D. (2008). HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Molecular cell, 32(6), 778–790. https://doi.org/10.1016/j.molcel.2008.10.026 Joh, R. I., Khanduja, J. S., Calvo, I. A., Mistry, M., Palmieri, C. M., Savol, A. J., Ho Sui, S. J., Sadreyev, R. I., Aryee, M. J., & Motamedi, M. (2016). Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs. Molecular cell, 64(6), 1088–1101. https://doi.org/10.1016/j.molcel.2016.11.020 Joh, R. I., Lawrence, M. S., Aryee, M. J., & Motamedi, M. (2021). Gene clustering drives the transcriptional coherence of disparate biological processes in eukaryotes. Systems Biology. https://doi.org/10.1101/2021.04.17.440292 Related Episodes Evolutionary Forces Shaping Mammalian Gene Regulation (Emily Wong) Chromatin Evolution (Arnau Sebé-Pedrós) The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Słuchasz nas regularnie? Zajrzyj na https://patronite.pl/radionaukowe***Ze szkoły mniej więcej pamiętamy obrazek: obszerna komóreczka otoczona błoną, w środku jądro, jakieś mitochondrium, całość pływa wygodnie w cytoplazmie. To oczywiście uproszczone przedstawienie. Podstawowa zmiana jest taka, że w komórkach nic wygodnie nie pływa: elementów jest bardzo dużo i są ciasno upchane. Ma to swoją funkcję. – Dzięki temu różne cząsteczki mogą ze sobą w uporządkowany sposób oddziaływać – wyjaśnia gość odcinka, dr Takao Ishikawa z Wydziału Biologii Uniwersytetu Warszawskiego. – Współczesne badania pokazują, że w komórce jest bardzo, bardzo tłoczno – dodaje. Rozmawiamy o niesamowicie złożonym i dopracowanym ewolucyjnie mechanizmie, jakim jest komórka.W jądrze komórkowym informacja genetyczna zostaje poddana transkrypcji, czyli przepisana na cząsteczki RNA. Nieduży fragment DNA rozwija się, przepisuje do RNA i zwija z powrotem. – Zapis genetyczny w każdej komórce w zasadzie jest taki sam, ale w zależności od tego, w jakiej tkance dana komórka się znajduje, to stopień superskrętów w różnych obszarach materiału genetycznego może być różny, co się przekłada właśnie na to, że różne geny są aktywne w jednej tkance, a inne w drugiej tkance – tłumaczy mój gość. Cząsteczki mRNA wydostają się z jądra komórkowego i trafiają do rybosomów, gdzie stykają się z innym rodzajem RNA: transferowym, tRNA. W rybosomie poszczególne aminokwasy łączą się w łańcuch białkowy, który odzwierciedla informację genetyczną. Komórki bowiem na co dzień są bardzo zajęte produkowaniem białek.W odcinku omawiamy też oczywiście pozostałe elementy komórki, a jest ich sporo. Będzie o błonie komórkowej, mitochondriach, retikulum i aparacie Golgiego. Dowiecie się też, jaka komórka w ludzkim ciele jest największa, a jaka najmniejsza, dlaczego nie do końca da się stworzyć sztuczną komórkę do badań i skąd wiemy, że mitochondria mają pochodzenie bakteryjne. Posłuchajcie, zachwycicie się swoim organizmem!
In today's episode, we had the pleasure of speaking with Stephen Liu, MD, about the use of tepotinib (Tepmetko) in patients with metastatic non–small cell lung cancer (NSCLC) harboring MET exon 14 skipping alterations. Dr Liu is an associate professor of medicine at Georgetown University, as well as the director of Thoracic Oncology and head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center in Washington, DC. In our exclusive interview, Dr Liu discussed key efficacy and safety findings from the phase 2 VISION trial (NCT02864992) that led to the FDA approval of tepotinib for this indication; the comparable response rates seen between tissue and liquid biopsy results, as well as across NSCLC treatment lines; and the importance of early biomarker testing, including RNA sequencing, to identify actionable mutations and optimize treatment.
Rebecca Culshaw Smith's Substack, “The Real AIDS Epidemic,” highlights core criticisms of mainstream HIV/AIDS theory, medical testing, pharmaceutical practices, and challenges to scientific orthodoxy. Based on her popular posts, interviews, and thematic content, these are 20 of the most important ideas advanced on her platform: 1. Questioning the existence of HIV as a unique virus, arguing that classic virological isolation (Koch's postulates) has not been fulfilled. 2. Highlighting the non-specificity and cross-reactivity of HIV antibody tests, leading to potential misdiagnosis. 3. Criticism of “viral load” PCR tests for not detecting whole pathogens but only RNA fragments. 4. Noting the shifting criteria for HIV test positivity over time, calling diagnostic standards into question. 5. Documenting long-term “non-progressors” and “elite controllers” who remain healthy without antiretroviral therapy. 6. Raising awareness of AIDS-defining illnesses in HIV-negative individuals and questioning causality. 7. Arguing that hazard from AIDS medications (e.g., AZT, Truvada, Prep) may outweigh their benefits, especially due to their toxicity and inconsistent trial results. 8. Critique of the marketing and deployment of pre-exposure prophylaxis (Prep), calling it a pharmaceutical “scandal” targeting people not at significant risk. 9.Exploring how COVID-19 public health narratives mirror what she views as deception and fear tactics from the AIDS era. 10. Disputing the epidemiological narrative that AIDS is globally caused by a single infectious agent, and highlighting massive regional/demographic inconsistencies. 11. Exposing groupthink, censorship, and reputational shaming used against scientists questioning the HIV/AIDS paradigm. 12. Emphasizing failures of antiretroviral therapy in preventing disease progression for many patients. 13.. Explaining the statistical and mathematical problems in foundational HIV/AIDS research and the “shaky foundation” of guiding studies. 14. Arguing that AIDS-defining diseases may often reflect toxicity, malnutrition, or existing comorbidities, not a distinct viral syndrome. 15. Linking historical and social factors (such as drug use, pharmaceutical incentives) to the creation and persistence of the HIV/AIDS establishment. 16. Alerting readers to issues of false positive antenatal screening and broader concerns about mass diagnostic testing in medicine. 17. Suggesting that “virus-like particles” in the body are misidentified as pathogens, not proof of HIV's existence. 18. Forecasting that advances in AI and technology may help overturn scientific “consensus” by increasing transparency and debate. 19 Publicly refuting hit pieces and attempts to “cancel” her work as ideological suppression, not science. 20.Advocating for a return to fundamental scientific rigor and genuine skepticism in medical research, especially around virology and public health narratives. These topics synthesize her core objections to HIV/AIDS orthodoxy and frame her Substack as a point of dissent and critique against modern medical paradigms and their social consequences.
Deze week in The Trueman Show: Ewald Stöteler Ewald is al ruim 45 jaar homeopaat en docent, en behoort wereldwijd tot de meest ervaren experts op dit gebied. In dit gesprek deelt hij zijn persoonlijke reis van de oncologie-afdeling in het ziekenhuis naar de diepere wereld van homeopathie. Hij legt uit waarom ziekte volgens hem niet in de materie zit, maar voortkomt uit verstoringen van de levenskracht — en waarom genezing altijd van binnenuit moet komen. In deze podcast: ⚡ Zelfgenezend vermogen “De dokter kan mij niet beter maken. De homeopaat ook niet. Ik kan alleen mezelf beter maken.”
In this episode of Founded & Funded, Madrona Investor Joe Horsman sits down with Jeff Leek and Rob Bradley, co-founders of Synthesize Bio, a foundation model company for biology that's unlocking experiments researchers could never run in the lab. Jeff, chief data officer at the Fred Hutch Cancer Center, and Rob, the McIlwain Family endowed chair in data science, share: •Why a startup the right fit for generative genomics •How generative genomics could reshape research, drug trials, and more •Why RNA is the right starting point for a generative AI model in biology •What this breakthrough means for the future of drug development •Why now is biology's “ChatGPT moment” •What makes Synthesize a true foundation model for biology (not a point solution) Whether you're a founder, biotech innovator, or AI researcher, this is a must-listen conversation about the intersection of AI, biology, and the future of medicine. Transcript:https://www.madrona.com/the-future-of-biology-is-generative-inside-synthesize-bios-rna-ai-model Chapters: (2:00) – Why a Foundation Model for Biology? (5:00) – The Case for RNA (7:00) – Biology's Large Language Model Analogy (9:00) – Solving Impossible Problems (11:00) – Validation & Testing (14:00) – Balancing Big Picture & Specific Biology (15:00) – Why a Company, Not Just a Lab (16:00) – Has Biology Had Its “ChatGPT Moment”? (19:00) – The Data Challenge (23:00) – Real-World Use Cases (26:00) – How Research Will Look in 10 Years (28:00) – Increasing the Odds of Discovery (29:00) – Clinical Trials & Precision Medicine (31:00) – Access & Next Steps
In this Mol Bio Minutes episode, Dr. Will Barnes, a plant biologist turned senior sales training specialist at Thermo Fisher Scientific, reflects on his time at the bench and the molecular lessons learned along the way. Will dives deep into the difficulties of RNA work in plant systems—carbohydrate contamination, genomic DNA carryover, secondary structure—and how these hindered everything from cloning and expression analysis to sequencing and qPCR.Through real-world anecdotes, he explains how high-quality reagents and systems helped him troubleshoot and resolve recurring issues, ultimately saving time and improving data reliability. He advocates for prioritizing upstream steps like RNA integrity and reverse transcription fidelity instead of chasing fixes at the end of the workflow.Listeners will leave with a deeper appreciation for the critical role of sample prep in molecular biology workflows and why investing in better tools pays off in cleaner data, greater confidence, and fewer headaches. Will's experience is a relatable reminder that smarter choices lead to better science.Helpful resource links mentioned in this episode:Learn about molecular cloning workflows and Gateway cloning solutionsExplore a variety of resources on reverse transcriptionTaqMan vs SYBR Chemistry for Real-Time PCRUsing MagMAX kits for automated nucleic acid extractionLearn more about, or order,SuperScript IV VILO Master MixExplore RNA/DNA quantification solutions, including Qubit and Nanodrop instruments----------------------------------------------------------------------------------------------Limited time promotional offer – Be one of the first 75 listeners to spend $500 and get 40% off all eligible reverse transcriptase, plastics, enzymes, and cloning reagents. Visit thermofisher.com/sombpromo for full detailsEnter promo code CAZDUA in the U.S.A.Enter promo code CZ7F19 in Canada Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
Le COVID-19 n'est pas qu'une maladie respiratoire
Wykład dr Grzegorza Łacha w ramach Dnia Odkrywców Kampusu Ochota [22 marca 2025 r.]Bardzo dokładne obliczenia dla atomów i cząsteczek chemicznych, którymi zajmował się wykładowca, uwzględniają efekty wynikające z połączenia mechaniki kwantowej i szczególnej teorii względności. Obliczenia te znalazły zastosowanie w dokładnych pomiarach stałej Boltzmanna i przyczyniły się do zmiany obowiązującej definicji jednostki temperatury — kelwina.dr Grzegorz Łach - absolwent Międzywydziałowych Indywidualnych Studiach Matematyczno-Przyrodniczych na Uniwersytecie Warszawskim. Doktorat uzyskał w Pracowni Chemii Kwantowej Wydziału Chemii UW. Grzegorz Łach pracuje obecnie w Katedrze Optyki Kwantowej i Fizyki Atomowej Wydziału Fizyki UW, gdzie zajmuje się szeroko pojętą fizyką obliczeniową i zastosowaniami w naukach pokrewnych. Wcześniej pracował w Instytucie Maxa Plancka, Uniwersytecie w Heidelbergu, University of Delaware, oraz odbył szereg staży w USA (Princeton, MIT) i Izraelu (Weizmann Institute of Science). Przez trzy lata odpoczywał od fizyki zajmując się bioinformatyką i zastosowaniami fizyki statystycznej w przewidywaniu struktury cząsteczek RNA w Międzynarodowym Instytucie Biologii Molekularnej i Komórkowej.Jeśli chcesz wspierać Wszechnicę w dalszym tworzeniu treści, organizowaniu kolejnych #rozmówWszechnicy, możesz:1. Zostać Patronem Wszechnicy FWW w serwisie https://patronite.pl/wszechnicafwwPrzez portal Patronite możesz wesprzeć tworzenie cyklu #rozmowyWszechnicy nie tylko dobrym słowem, ale i finansowo. Będąc Patronką/Patronem wpłacasz regularne, comiesięczne kwoty na konto Wszechnicy, a my dzięki Twojemu wsparciu możemy dalej rozwijać naszą działalność. W ramach podziękowania mamy dla Was drobne nagrody.2. Możesz wspierać nas, robiąc zakupy za pomocą serwisu Fanimani.pl - https://tiny.pl/wkwpkJeżeli robisz zakupy w internecie, możesz nas bezpłatnie wspierać. Z każdego Twojego zakupu średnio 2,5% jego wartości trafi do Wszechnicy, jeśli zaczniesz korzystać z serwisu FaniMani.pl Ty nic nie dopłacasz!3. Możesz przekazać nam darowiznę na cele statutowe tradycyjnym przelewemDarowizny dla Fundacji Wspomagania Wsi można przekazywać na konto nr:33 1600 1462 1808 7033 4000 0001Fundacja Wspomagania WsiZnajdź nas: https://www.youtube.com/c/WszechnicaFWW/https://www.facebook.com/WszechnicaFWW1/https://anchor.fm/wszechnicaorgpl---historiahttps://anchor.fm/wszechnica-fww-naukahttps://wszechnica.org.pl/#nauka #fizyka #metr #kilogram #sekunda #czas #waga #miara #matematyka #doko
Listen & subscribe on Apple, Spotify, YouTube, and other platforms. Welcome everyone to the weekly San Diego Tech News! I'm Neal Bloom from Rising Tide Partners and the Tacos and Tech Podcast. My co-host in this episode is Fred Grier, journalist and author of The Business of San Diego substack. He covers the ins-and-outs of the startup world including breaking news, IPOs, fundraising rounds, and M&A through his newsletter. Before we dive in, we wanted to thank and ask our listeners to help us grow the show, leave a review and share with one other person who should be more plugged in with the SD Tech Scene. Thank you for the support and for helping us build the San Diego Startup Community! 9/19 Broader Defense Tech: Harpoon x Firestorm Mixer Debrief El Segundo Defense Tech Mixer Debrief Firestorms Labs opens 60,000 SFT Facility in Mira Mesa Biotech: Treeline Biosciences emerges from stealth with $200M backed by ARCH Venture. Arnatar Therapeutics focused on precision RNA therapies emerges from stealth. Debut Bio raises and expands to Asia Yatiri - acquired another startup Luna Diabetes raises a Series A Curated Events List – For full list – check The Social Coyote Sept 26 - Defense Tech Gathering Oct 3-5 Startup Weekend Oct 6-10 SD Startup Week
In questa puntata 579 Ilaria e Valeria vi portano in un viaggio che passa dai laboratori di biologia ai prati fioriti, con una sosta con Giuliana nel mondo dell'intelligenza artificiale. Tre storie molto diverse, ma tutte con un punto in comune: la scienza sa ancora sorprenderci.Valeria apre la puntata parlando di come le nostre cellule si difendono dai virus. Il sistema interferonico è come un allarme che si attiva al momento giusto e deve spegnersi quando la minaccia finisce. Ma che succede se un pezzo di questo sistema, la proteina ISG15, non c'è? Stranamente le cellule se la cavano lo stesso, mantenendo un “basso rumore di fondo” che le rende pronte a combattere. Da qui nasce l'idea: se stimoliamo artificialmente alcuni geni che imitano questa condizione, possiamo avere un antivirale universale? I primi esperimenti dicono di sì: dieci geni sembrano capaci di controllare infezioni diverse e ridurre i sintomi del COVID nei criceti. Non male come superpotere molecolare.Giuliana intervista Valeria Zuccoli, data scientist appassionata di computer vision che ha lavorato diversi anni nel settore della videosorveglianza. Insieme parliamo di come l'intelligenza artificiale viene applicata alle telecamere di videosorveglianza: dal ladro che cerca di entrare in casa nostra, alla prevenzione degli infortuni sul lavoro, Valeria ci accompagna in un breve viaggio sugli occhi intelligenti che ci circondano, senza dimenticare qualche notizia curiosa.Infine, Ilaria porta tutti in un prato davanti a un soffione. Sembra un gioco da bambini, ma la fisica nascosta dietro quei semi è da premio scientifico. Dipende tutto da come tira il vento: alcuni semi volano via subito, altri resistono come se fossero incollati. Un trucco evolutivo che assicura la massima diffusione.Tre voci, tre mondi, una sola puntata. Pronti a scoprire come i virus, l'AI e i soffioni si intrecciano? Premete play e lasciatevi sorprendereDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/scientificast-la-scienza-come-non-l-hai-mai-sentita--1762253/support.
Breastmilk is Dynamic Cellular and transcriptional diversity over the course of human lactation This recent 2022 paper in the Proceedings of the National Academy of Sciences by Dr. Nyqiust and colleagues is a site for sore eyes. It offers a remarkable, high-resolution portrait of how the cellular landscape of human breast milk (hBM) shifts over time. The authors capture something both scientifically rich and uniquely human: the dynamic, living composition of milk as it adapts to the changing needs of mother and child. The abstract: "Human breast milk is a dynamic fluid that contains millions of cells, but their identities and phenotypic properties are poorly understood. We generated and analyzed single-cell RNA-sequencing (scRNA-seq) data to characterize the transcriptomes of cells from hBM across lactational time from 3 to 632 d postpartum in 15 donors. We found that the majority of cells in hBM are lactocytes, a specialized epithelial subset, and that cell-type frequencies shift over the course of lactation, yielding greater epithelial diversity at later points. Analysis of lactocytes reveals a continuum of cell states characterized by transcriptional changes in hormone-, growth factor-, and milk production-related pathways. Generalized additive models suggest that one subcluster, LC1 epithelial cells, increases as a function of time postpartum, daycare attendance, and the use of hormonal birth control. We identify several subclusters of macrophages in hBM that are enriched for tolerogenic functions, possibly playing a role in protecting the mammary gland during lactation. Our description of the cellular components of breast milk, their association with maternal–infant dyad metadata, and our quantification of alterations at the gene and pathway levels provide a detailed longitudinal picture of hBM cells across lactational time. This work paves the way for future investigations of how a potential division of cellular labor and differential hormone regulation might be leveraged therapeutically to support healthy lactation and potentially aid in milk production." (Nyquist et. al. 2022) And more information on breastmilk immunology and a recipe. Dr. M
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the fastest-growing etiology of hepatocellular carcinoma (HCC). This work identifies novel gene and lipid associations in human MASLD-driven HCC that may be exploited for therapeutic benefit. Methods: Human HCC tumor (n=8) and adjacent non-tumor samples (n=8) were obtained from the Biospecimen Procurement and Translational Pathology Shared Resource Facility at the University of Kentucky Markey Cancer Center. All patients met cardiometabolic MASLD criteria and were negative for viral hepatitis. Hematoxylin and eosin (H&E) staining was used for pathological determination of tumor and adjacent nontumor tissue. Lipids were extracted using a methyl-tert-butyl ether extraction method and subjected to lipidomics by the West Coast Metabolomics Center. RNA was isolated and used for bulk sequencing. Data were analyzed using paired nonparametric analyses via a Wilcoxon or Mann-Whitney test, as appropriate. Results: Histological analysis by H&E showed significant lipid vacuole accumulation in HCC tumors relative to nontumor tissue. Lipidomic analysis revealed significant increases in long-chain nonesterified monounsaturated fatty acids (MUFAs; C16:1, C18:1, C20:1) and MUFA-enriched phospholipids (PC30:1, PC32:1, PE32:1, and PC36:1) in tumors relative to nontumor tissue. No significant differences were observed in nonesterified polyunsaturated fatty acids (PUFAs; C18:2, C20:4, and C22:6), PUFA-enriched phospholipids (C36:4, C38:4, C38:6, C40:6), or in fatty acid esters of hydroxy fatty acids (FAHFAs; C38:2, C38:4, C38:6). However, both MUFA- (C14:1, C18:1) and PUFA-enriched acylcarnitines (C18:2, C18:3) were collectively reduced in human tumors. Differential analysis of RNA sequencing revealed fatty acid oxidation genes (CPT1A, CPT2, ACADL, ACADM, ACADS, HADHA) were significantly reduced in tumor versus nontumor tissue. Further, genes involved in de novo lipogenesis were largely dysregulated (e.g. no differences in SREBF1 or FASN; increases in ACLY, ACACA, and SCD1; decreases in ACSL1) in tumor versus nontumor tissue. Conclusions: These results suggest human HCC tumors exhibit a reduced capacity to undergo mitochondrial β-oxidation resulting in accumulation of free and esterified MUFAs with concomitant reductions in MUFA-carnitines. Current studies are underway to determine the mechanisms by which impairment of hepatic MUFA catabolism via FAO promotes the development of HCC in mice.
Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. Evan sits down with Walter Isaacson to understand how Doudna’s upbringing in Hilo, Hawaii influenced her trajectory as a gene editing scientist. And how the history of gene editing might have started with understanding DNA, but soon after, it became clear the real secret lay with its underrated sibling molecule, RNA.See omnystudio.com/listener for privacy information.
Im Gespräch mit Moritz erklärt Dr. Peter Köppel, was Nukleotide sind und wie die Bausteine von DNA und RNA unsere ganz alltägliche Gesundheit beeinflussen. Natürlich gibt es auch Tipps, um die Nukleotid-Zufuhr zu verbessern.
Guest: Paola Marignani, PhD, EMBA While smoking remains a key risk factor for lung cancer, up to 25 percent of cases occur in people who have never smoked, leaving significant gaps in our understanding of causation and diagnostics. Dr. Paola Marignani explores emerging discoveries in gene variants unique to never-smokers, uncovered through single-cell RNA sequencing and machine learning. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
TWiV re-issues our 100th episode which featured a discussion of viruses with David Baltimore, an exemplary scientist and Vincent's exemplary mentor, who passed on 6 September 2025. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: David Baltimore Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV David's early papers on poliovirus and mengovirus RNA synthesis Reverse transcriptase found by Baltimore and Temin (pdfs) Nobel Prize in Physiology or Medicine 1975 The David Baltimore asteroid belt Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
Audio roundup of selected biopharma industry content from Scrip over the business week ended September 5, 2025. In this episode: the US MASH market after Wegovy's approval; AstraZeneca and Mineralys in close hypertension race; United Therapeutics' Phase III win in IPF; Corsera aims to predict and prevent cardiovascular disease; and Ionis's RNA-targeted win in severe hypertriglyceridemia. https://insights.citeline.com/scrip/podcasts/scrips-five-must-know-things/quick-listen-scrips-five-must-know-things-RKP4E4CFGFGGXBRVXTI73V27U4/ This episode was produced with the help of AI text-to-voice and voice emulation tools. Playlist: soundcloud.com/citelinesounds/sets/scrips-five-must-know-things
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world. Robert F. Kennedy Jr. faced the Senate Finance Committee in a tense hearing amidst calls for the removal of the health secretary. The committee questioned Kennedy on his recent actions, including the firing of CDC director Susan Monarez. Meanwhile, the FDA's new rare disease pathway received mixed reactions, with some questioning its tangible impacts. AC Immune downsized and refocused its pipeline, while Kennedy proposed adding seven new vaccine advisors to the ACIP. Other news included successful RNA editing in an AATD study, demands for YouTube to remove anti-vaccine videos, and a new framework for rare disease approvals by the FDA. Thank you for tuning in to today's episode of Pharma and Biotech daily.
In this episode of the Epigenetics Podcast, we talked with Arnau Sebé-Pedrós from the Center for Genomic Regulation in Barcelona about his work on chromatin evolution. The Interview starts by examining specific research findings, including his seminal 2018 paper demonstrating whole-organism single-cell transcriptomics to map larval and adult cell types in the model organism Nematostella vectensis. Dr. Sebe-Pedros recounted the challenges and triumphs faced when delving into single-cell studies of non-model organisms, revealing the innovative strategies employed in the lab to overcome these hurdles. Shifting gears, we touched upon his work comparing cell types and molecular pathways in reef-building corals through single-cell RNA sequencing, contributing to our understanding of evolutionary conservation and divergence within the cnidarian lineage. We discussed how this comparative approach not only adds to knowledge about coral biology but also enhances methodological frameworks in ecological studies. In addition, Dr. Sebe-Pedros shared insights into ongoing efforts to reconstruct eukaryotic chromatin evolution using comparative proteomics and genomics analysis, as well as the mechanisms of genomic regulation in various species. His reflections on the sharing of experimental insights across research groups illustrated the collaborative spirit prevalent in the scientific community, particularly regarding endeavors like the Biodiversity Cell Atlas consortium aimed at expanding single-cell efforts across the tree of life. The episode culminated with Dr. Sebe-Pedros's thoughts on the revolutionary impact of functional genomic technologies and the vast potential they hold for answering longstanding questions in evolutionary biology. With an emphasis on epigenetics, he defined this field as encompassing any information not encoded directly in the DNA, especially in its role in establishing cell identity and differentiation. References https://www.biodiversitycellatlas.org Sebé-Pedrós, A., Saudemont, B., Chomsky, E., Plessier, F., Mailhé, M. P., Renno, J., Loe-Mie, Y., Lifshitz, A., Mukamel, Z., Schmutz, S., Novault, S., Steinmetz, P. R. H., Spitz, F., Tanay, A., & Marlow, H. (2018). Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq. Cell, 173(6), 1520–1534.e20. https://doi.org/10.1016/j.cell.2018.05.019 Sebé-Pedrós, A., Chomsky, E., Pang, K., Lara-Astiaso, D., Gaiti, F., Mukamel, Z., Amit, I., Hejnol, A., Degnan, B. M., & Tanay, A. (2018). Early metazoan cell type diversity and the evolution of multicellular gene regulation. Nature ecology & evolution, 2(7), 1176–1188. https://doi.org/10.1038/s41559-018-0575-6 Kim, I.V., Navarrete, C., Grau-Bové, X. et al. Chromatin loops are an ancestral hallmark of the animal regulatory genome. Nature 642, 1097–1105 (2025). https://doi.org/10.1038/s41586-025-08960-w Related Episodes Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes) Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) Transposable Elements in Gene Regulation and Evolution (Marco Trizzino) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
We returned from the Labor Day holiday to a spate of intriguing deals, including two that could surpass $2 billion: Vertex's new pact with Enlaza for autoimmune disease—which the Casgevy maker hopes could ease conditioning for the sickle cell/beta thalassemia gene therapy—and Novartis' agreement with Arrowhead for neurodegenerative diseases such as Parkinson's. But as we look ahead, Thursday's Senate Finance Committee will be the focus this week, as Health and Human Services Secretary Robert F. Kennedy Jr. will answer questions after the ousting of CDC Director Susan Monarez. Her departure is reportedly linked to changes to the regulation of COVID-19 vaccines, for which the FDA last week issued restricted approvals to Moderna, Pfizer/BioNTech and Novavax and rescinded the emergency use authorizations. The next ACIP meeting—where COVID-19 vaccines will be on the agenda—is set for Sept. 18 and 19. In the weight loss arena, Novo Nordisk presented results from a real-world study this weekend at the European Society of Cardiology Congress in Madrid showing that Wegovy cut the risk of heart attack, stroke or death by 57% compared to Eli Lilly's tirzepatide in people with obesity and cardiovascular disease. The company also continues to throw money into the space, last week inking a $550 million deal with Replicate for RNA-based treatments for obesity and diabetes. Meanwhile, Lilly is dropping studies of one oral obesity candidate as another nears a regulatory filing. Finally, the FDA greenlit the first GLP-1 generic for obesity. We also discuss reactions to the FDA's new guidance on radiopharma drug development, four recent approvals for rare diseases, and everything you ever wanted to know about SPACs.
Remixed- Path to KOLs: The New Chemist Podcast's Global Journey in Science, Pharma, and Education: Interview with Mohan Uttarwar, CEO & Co-Founder of 1Cell.Ai---In this episode we provide and educational episode remix made with software assistance ( for educational purposes only) , we sit down with Mohan Uttarwar, CEO & Co-Founder of 1Cell.Ai, to explore how AI-driven single-cell analytics are revolutionizing precision oncology. Discover how the OncoIncytes platform merges ctDNA, live CTCs, single-cell RNA and proteomics for a real-time, multimodal tumor profile—and learn how these insights are sharpening patient selection, accelerating ADC trials, and delivering earlier, more accurate measures of therapeutic response. Mohan also shares his playbook for building a capital-efficient biotech across Silicon Valley and India, the emerging trends set to reshape drug development, and practical advice for chemists, data scientists, and founders looking to break into the field. Tune in this August for a deep dive into the future of cancer research and drug discovery.--Please note: The views of this podcast represent those of my guest(s) and I, and do not constitute professional or medical advice or consultation. Please see a medical professional or healthcare professional for advice, suggestions and consultations. We disclaim any loss in any way.Music citation: Open source
Send us a textIn this episode of the Life Science Success Podcast my guest is Mark Stead, Head of Business Development at Atomic AI, a pioneering biotech company using artificial intelligence and structural biology to develop innovative RNA-targeted therapeutics. Mark brings over 12 years of experience in biotechnology, with a proven track record of negotiating high-value partnerships and driving strategic collaborations in drug discovery.00:00 Introduction to the Life Science Success Podcast00:30 Meet Mark Stead: Journey into Life Sciences03:26 Career Insights: From Amgen to Atomic AI11:20 Innovations at Atomic AI: Leveraging AI and Structural Biology19:37 The Future of AI in Drug Discovery31:03 Leadership and Personal Insights39:38 Conclusion and Farewell
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. CDC Director Monarez was fired after less than a month due to internal unrest over new COVID-19 vaccine policies. Novo Nordisk is investing over $500 million in RNA obesity treatments. The FDA has approved updated COVID-19 shots from Pfizer, Moderna, and Novavax with restrictions, causing concern among some groups. Prothena's Alzheimer's drug, PRX012, has shown high rates of brain swelling in Phase I testing. Novo Nordisk is collaborating with other companies on cardiometabolic treatments. The pharma industry is facing challenges and changes, with layoffs and restructurings occurring at various companies. Massachusetts has seen a decline in R&D and biomanufacturing jobs in 2024. Various webinars and events are being held to discuss topics such as pharma manufacturing and data accessibility. Job opportunities in the pharmaceutical industry include positions in business analysis, quality engineering, and project engineering.
The potential breakthrough in RNA vaccine technology has been increasingly discussed on social media. This episode looks at one promising study and its early, early results so far. UF GBM study: https://doi.org/10.1016/j.cell.2024.04.003 RNA Treatment Vaccine Review: https://doi.org/10.1002/ctm2.1384
On today's episode of The Ultimate Assist, John Stockton and Ken Ruettgers sit down with Dr. Brian Hooker, scientist, autism dad, and chief scientific officer at Children's Health Defense, for one of the most explosive interviews yet.Dr. Hooker recounts his son's devastating vaccine injury, his whistleblower role in exposing the CDC's suppression of autism data, and the 16-year nightmare his family endured in vaccine court—only to be denied justice. He unpacks conflicts of interest in vaccine research, the dangers of mercury and aluminum still in shots, and how studies are manipulated to hide the truth. From shedding and genetic susceptibility to Tylenol's hidden role in vaccine injury, Hooker explains what mainstream science refuses to discuss.He also reveals the inside story of testifying alongside Senator Ron Johnson, how Robert F. Kennedy Jr. is shaking up the health establishment, and why new self-amplifying RNA vaccines could be the biggest threat yet.
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.AbbVie has acquired Gilgamesh Pharmaceuticals for $1.2 billion, focusing on neurology and depression treatments. This move follows AbbVie's previous failure with Emraclidine in schizophrenia treatment. The biotech industry's IPO stalemate appears to be ending, with Lb Pharma planning an IPO to fund a phase III-ready schizophrenia asset. The FDA has pulled Valneva's chikungunya shot from the market due to safety concerns, and several obesity drugs have failed to make it to market. Meanwhile, Arnatar is working on advancing RNA therapies beyond silencing.In other news, the disappointment of oral obesity therapies is discussed, with Novo emerging as a leader in the field. Trials for Eli Lilly's Orforglipron and Viking Therapeutics' VK2735 were underwhelming, leading to increased interest in weight loss pills in low- and middle-income countries. Capricor Therapeutics plans to fight FDA rejection of its DMD cardiomyopathy treatment, while a study in JAMA contradicts claims of corruption in vaccine advisory committees. Updates on cancer, cell and gene therapy are also provided.Stay tuned for more updates and feel free to suggest topics for future coverage.
New Discovery Shakes Life's Origins: Proof of Intelligent Design? This eye-opening conversation uncovers the complexities of life's origin, scrutinizing the RNA world hypothesis against molecular biology's harsh realities. Experts Dr. Brian Miller and Dr. Casey Luskin join Lenny to discuss DNA-protein interdependence, polymerization challenges in water, and why self-organization doesn't explain life's emergence. With probabilistic hurdles in focus, they emphasize the need for a paradigm shift in scientific research to better address these fundamental questions.
Joe Untamed tackles two urgent battles shaping America's future: the rise of radical Islamist influence and the war over truth in public health. Robert Spencer, renowned scholar and director of Jihad Watch, joins us to break down the growing presence of Islamist ideology in U.S. communities—from mass gatherings in Michigan to city councils now dominated by Muslim politicians. What does this mean for American law, culture, and national security? Spencer peels the onion back on the elites enabling this transformation and warns what's at stake if we continue down this path unchecked. Then, Dr. Robert Malone—the original inventor of mRNA vaccine technology—returns to reveal how entrenched bureaucrats and Big Pharma allies are weaponizing science against the American people. With new developments inside HHS and RFK Jr.'s sweeping reforms, Malone exposes the deep state's retaliation, the dangers of indemnifying industries like RNA pesticides, and the long-term health consequences hidden from public view. From vaccine schedules to regulatory corruption, his insights strike at the heart of America's medical and political crises. Together, Spencer and Malone highlight the same underlying truth: powerful elites, whether in religion, government, or corporate boardrooms, are eroding American freedom from within. This is not just about foreign threats or public health—it's about the survival of liberty itself. Tonight's show is a wake-up call, offering clarity, urgency, and solutions for anyone ready to stand against the forces trying to reshape America in their image.
Jordan Sather and Nate Prince return with another hard-hitting episode of MAHA News, diving into the week's biggest health and freedom stories. They kick things off with the Pete and Bobby Challenge, where Pete Hegseth and RFK Jr. put their strength to the test in a push-up and pull-up competition that has everyone talking. From there, the hosts shift into the serious implications of glyphosate spraying in Canada and the broader dangers of genetically engineered crops, highlighting how hidden RNA tinkering in food could impact human genetics and health. The discussion then takes aim at the American Academy of Pediatrics, which is under fire for its push to remove vaccine exemptions and its continued cozy ties with big pharma giants like Pfizer, Merck, and Moderna. RFK Jr.'s sharp rebuke of the AAP sparks debate about liability, childhood vaccine schedules, and health freedom. With side conversations on raw milk legalization, natural detox strategies, and the cultural psyop of green lawns, this episode weaves humor, practicality, and blunt truth into an engaging exploration of health sovereignty.
Matters Microbial #104: Antibiotic “Tolerance” and Biofilms August 21, 2025 Today, Dr. Boo Shan Tseng, Associate Professor at the University of Nevada Las Vegas School of Life Sciences, joins the #QualityQuorum to discuss bacterial biofilms and antibiotic tolerance. Host: Mark O. Martin Guest: Boo Shan Tseng Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A video overview of biofilms. A comprehensive review article on biofilms. An article describing the impact biofilms have on disease. An article describing the impact of biofilms on implanted medical devices. A link to the Center for Biofilm Engineering at Montana State University that has MANY links of interest. An overview of biofilm development. An overview of confocal laser microscopy. Studying biofilms in flow cells. An article about the role proteins play in biofilm formation, which intersects with the Tseng group's research. The technique of single cell RNA seq. The technique of mRNA-FISH. An article about porins in bacteria, and how that can relate to antibiotic resistance. An article by Dr. Tseng and coworkers on the eDNA and biofilms discussed today. A lovely video of Dr. Tseng talking about the research she and her colleagues carry out in the laboratory. Dr. Tseng's biography from the American Society for Microbiology. Dr. Tseng's laboratory group website with wonderful links and images. Dr. Tseng's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
Hi friends! We're taking a much-needed August pause—we'll have new episodes for you in September. In the meanwhile, enjoy this pick from our archives! _____ [originally aired February 8, 2024] Where do memories live in the brain? If you've ever taken a neuroscience class, you probably learned that they're stored in our synapses, in the connections between our neurons. The basic idea is that, whenever we have an experience, the neurons involved fire together in time, and the synaptic connections between them get stronger. In this way, our memories for those experiences become minutely etched into our brains. This is what might be called the synaptic view of memory—it's the story you'll find in textbooks, and it's often treated as settled fact. But some reject this account entirely. The real storehouses of memory, they argue, lie elsewhere. My guest today is Dr. Sam Gershman. Sam is Professor of Psychology at Harvard University, and the director of the Computational Cognitive Neuroscience Lab there. In a recent paper, he marshals a wide-ranging critique of the synaptic view. He makes a compelling case that synapses can't be the whole story—that we also have to look inside the neurons themselves. Here, Sam and I first discuss the synaptic view and the evidence that seems to support it. We then talk about some of the problems with this classic picture. We consider, for example, cases where memories survive the radical destruction of synapses; and, more provocatively, cases where memories are formed in single-celled organisms that lack synapses altogether. We talk about the dissenting view, long lurking in the margins, that intracellular molecules like RNA could be the real storage sites of memory. Finally, we talk about Sam's new account—a synthesis that posits a role for both synapses and molecules. Along the way we touch on planaria and paramecia; spike-timing dependent plasticity; the patient H.M.; metamorphosis, hibernation, and memory transfer; the pioneering work of Beatrice Gelber; unfairly maligned ideas; and much, much more. Before we get to it, one important announcement: Applications are now open for the 2024 Diverse Intelligences Summer Institute (or DISI)! The event will be held in beautiful, seaside St Andrews, Scotland, from June 30 to July 20. If you like this show—if you like the conversations we have and the questions we ask—it's a safe bet that you'd like DISI. You can find more info at disi.org—that's disi.org. Review of applications will begin on Mar 1, so don't delay. Alright friends, on to my conversation about the biological basis of memory with Dr. Sam Gershman. Enjoy! Notes and links 4:00 - A general audience article on planarian memory transfer experiments and the scientist who conducted them, James V. McConnell. 8:00 - For more on Dr. Gershman's research and general approach, see his recent book and the publications on his lab website. 9:30 - A brief video explaining long-term potentiation. An overview of “Hebbian Learning.” The phrase “neurons that fire together wire together” was, contrary to widespread misattribution, coined by Dr. Carla Shatz here. 12:30 - The webpage of Dr. Jeremy Gunawardena, Associate Professor of Systems Biology at Harvard University. A recent paper from Dr. Gunawardena's lab on the avoidance behaviors exhibited by the single-celled organism Stentor (which vindicates some disputed, century-old findings). 14:00 - A recent paper by C. R. Gallistel describing some of his views on the biological basis of memory. 19:00 - The term “engram” refers to the physical trace of a memory. See recent reviews about the so-called search for the engram here, here, and here. 20:00 - An article on the importance of H.M. in neuroscience. 28:00 - A review about the phenomenon of spike-timing dependent plasticity. 33:00 - An article, co-authored by former guest Dr. Michael Levin, on the evidence for memory persistence despite radical remodeling of brain structures. See our episode with Dr. Levin here. 35:00 - A study reporting the persistence of memories in decapitated planarians. A popular article about these findings. 36:30 - An article reviewing one chapter in the memory transfer history. Another article reviewing evidence for “vertical” memory transfer (between generations). 39:00 - For more recent demonstrations of memory transfer, see here and here. 40:00 - A paper by Dr. Gershman, Dr. Gunawardena, and colleagues reconsidering the evidence for learning in single cells and describing the contributions of Dr. Beatrice Gelber. A general audience article about Gelber following the publication of the paper by Dr. Gershman and colleagues. 45:00 – A recent article arguing for the need to understand computation in single-celled organisms to understand how computation evolved more generally. 46:30 – Another study of classical conditioning in paramecia, led by Dr. Todd Hennessey. 49:00 – For more on plant signaling, see our recent episode with Dr. Paco Calvo and Dr. Natalie Lawrence. 56:00 – A recent article on “serial reversal learning” and its neuroscientific basis. 1:07:00 – A 2010 paper demonstrating a role for methylation in memory. Recommendations The Behavior of the Lower Organisms, by Herbert Spencer Jennings Memory and the Computational Brain, by C. R. Gallistel and Adam Philip King Wetware, by Dennis Bray Many Minds is a project of the Diverse Intelligences Summer Institute, which is made possible by a generous grant from the John Templeton Foundation to Indiana University. The show is hosted and produced by Kensy Cooperrider, with help from Assistant Producer Urte Laukaityte and with creative support from DISI Directors Erica Cartmill and Jacob Foster. Our artwork is by Ben Oldroyd. Our transcripts are created by Sarah Dopierala. Subscribe to Many Minds on Apple, Stitcher, Spotify, Pocket Casts, Google Play, or wherever you listen to podcasts. You can also now subscribe to the Many Minds newsletter here! We welcome your comments, questions, and suggestions. Feel free to email us at: manymindspodcast@gmail.com. For updates about the show, visit our website or follow us on Twitter (@ManyMindsPod) or Bluesky (@manymindspod.bsky.social).
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science
For a long time, scientists have wondered how life has emerged from inanimate chemistry, and whether Earth is the only place where it exists. Charles Darwin speculated about life on Earth beginning in a warm little pond. Some of his contemporaries believed that life existed on Mars. It once seemed inevitable that the truth would be known by now. It is not. For more than a century, the origins and extent of life have remained shrouded in mystery. But, as Mario Livio and Jack Szostak reveal in Is Earth Exceptional?: The Quest for Cosmic Life (Basic Books, 2024), the veil is finally lifting. The authors describe how life's building blocks--from RNA to amino acids and cells--could have emerged from the chaos of Earth's early existence. They then apply the knowledge gathered from cutting-edge research across the sciences to the search for life in the cosmos: both life as we know it and life as we don't. Why and where life exists are two of the biggest unsolved problems in science. Is Earth Exceptional? is the ultimate exploration of the question of whether life is a freak accident or a chemical imperative. Learn more about your ad choices. Visit megaphone.fm/adchoices
Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.## Viking Therapeutics' oral obesity pill, VK2735, achieved over 12% weight loss in a clinical trial, causing their stock to plummet due to safety concerns. The pending approval of oral Wegovy has also brought attention to high-dose peptides.## Meanwhile, leaked information reveals a proposed overhaul of vaccine strategies and access to novel therapies. The FDA rejected PTC Therapeutics' drug for Friedreich's ataxia, and Novo Nordisk reassured investors of their capacity to supply oral semaglutide. Fedegari now offers customized solutions for the pharmaceutical industry, and Vantai is in talks with Halda for a potential proteomics partnership. ## Other news includes conflicts of interest in vaccine committees declining, RegenxBio facing a delay in their gene therapy approval, and Genentech ending a partnership with Adaptive Biotechnologies. Kriya raises $313 million for gene therapy, Merck KGaA invests in RNA-targeting technology, and Novo Nordisk receives approval for Wegovy.
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
BUFFALO, NY – August 15, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 13, 2025, titled “Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.” In this study, first authors Valeriy Domenyuk and Kasey Benson, along with corresponding author David Spetzler from Caris Life Sciences in Irving, Texas, introduce MI Cancer Seek, an FDA-approved test designed to deliver comprehensive tumor profiling. MI Cancer Seek demonstrated strong concordance with other FDA-approved companion diagnostics and serves as a powerful tool to guide treatment decisions in both adult and pediatric cancer patients. Cancer remains one of the most complex and diverse diseases to treat. With many targeted therapies currently FDA-approved, selecting the right one for a specific patient requires detailed genetic insights. MI Cancer Seek addresses this need by analyzing both DNA and RNA from a single tumor sample. The tool identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers. One of the most significant strengths of MI Cancer Seek is its ability to deliver accurate and reliable results from minimal tissue input (50 ng). Even when analyzing formalin-fixed paraffin-embedded samples, which are widely used but often degraded, the test maintained high levels of accuracy. It successfully detected important genetic alterations such as PIK3CA, EGFR, BRAF, and KRAS/NRAS mutations and measured tumor mutational burden (TMB) and microsatellite instability (MSI), both of which are key indicators for immunotherapy response. In clinical comparisons, the test achieved over 97% agreement with other FDA-approved diagnostic tools, confirming its reliability in detecting critical biomarkers. Notably, it showed near-perfect accuracy in identifying MSI status in colorectal and endometrial cancers. The researchers also demonstrated that the test maintains precision across different lab conditions and varying DNA input levels, confirming its robustness for routine clinical use. Beyond its role as a companion diagnostic, MI Cancer Seek incorporates additional features developed under its predecessor, MI Tumor Seek Hybrid. These include detection of homologous recombination deficiency, structural variants, and cancer-related viruses. It also includes advanced tools such as the Genomic Probability Score for identifying the tissue of origin in cancers of unknown primary, as well as a gene signature to guide first-line chemotherapy in colorectal cancer. “One limitation to be considered is the low PPA for ERBB2 CNA detection.” By offering deeper genetic insights from a single, small sample, MI Cancer Seek has the potential to streamline diagnostics, reduce testing costs, and connect patients to effective therapies more quickly. As precision medicine continues to expand, this assay stands out as a comprehensive and efficient solution for meeting the evolving needs of modern oncology. DOI - https://doi.org/10.18632/oncotarget.28761 Correspondence to - David Spetzler - dspetzler@carisls.com Video short - https://www.youtube.com/watch?v=D4hd2FxCYY8 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/postsDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAEmail: info.fromthespectrum@gmail.com
HHS Director Robert F. Kennedy, Jr declared on Friday, August 8, 2024 the CDC and HHS will suspend the use of mRNA vaccines for COVID-19 treatment, and restrict its use in future vaccines due to components that trun RNA into DNA, making the vaccines highly ineffective as well as potentially dangerous.In this short clip. Mr. Kennedy outlines his reasonings and what the Deaprtment and health researchers have discovered thus far since the implementation of mRNAwas introduced four years ago as a therapy for treating coronavirus.
Send us a textIn this episode of the Life Science Success Podcast my guest is John Schmitt, a military veteran, entrepreneur, and Co-Founder & CEO of iXpressGenes who is leveraging innovative RNA biomarker technologies to revolutionize trauma screening in healthcare. With over 20 years of leadership experience in the U.S. Army and a Master's degree in Microbiology and Immunology, John is dedicated to developing data-driven solutions for early detection and prevention of trauma-related diseases.00:00 Introduction and Podcast Overview01:02 Welcoming the Guest: John Schmitt02:00 John Schmitt's Journey to Biotechnology05:58 Military Experience and Leadership Insights13:09 Founding iXpressGenes: The Origin Story17:31 Mission and Objectives of iXpressGenes23:08 Challenges and Innovations in Biomarker Technologies27:42 Personal Leadership and Inspirations35:00 Conclusion and Podcast Wrap-Up
In this episode of the Epigenetics Podcast, we talked with Erica Korb from the University of Pennsylvania about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. Dr. Korb discusses the focus of her lab, which centers on epigenetic mechanisms impacting gene regulation in neurons. Her research primarily examines histone biology and its connection to neurodevelopmental disorders, including autism spectrum disorder and intellectual disabilities. Dr. Korb expounds on the collaborative environment at UPenn's Epigenetics Institute, emphasizing how the rich diversity of research topics fosters innovative ideas and projects within the community. Reflecting on her earlier work from her postdoctoral studies, Dr. Korb discusses her first significant findings regarding the protein BRD4. This work demonstrated BRD4's role in mediating transcriptional regulation crucial for learning and memory processes. She explains how disrupting this protein's function in neurons hindered critical gene activations required for memory formation in mice. This foundational understanding opened avenues for exploring the broader implications of chromatin regulation in various neurodevelopmental conditions. Transitioning into her current research endeavors, Dr. Korb reveals how she aims to expand her focus beyond Fragile X syndrome. With her lab now investigating multiple chromatin regulators implicated in various forms of autism spectrum disorders, she describes a recent project where RNA sequencing exposed substantial overlaps in gene expression changes associated with five distinct chromatin modifiers, each contributing uniquely to neuronal function while collectively demonstrating sensitivity to chromatin disruptions. A significant portion of the discussion centers around Dr. Korb's unexpected exploration into how COVID-19 intersects with chromatin biology through a phenomenon known as histone mimicry. Leveraging bioinformatic tools during the pandemic, her lab discovered that certain viral proteins mimic histone sequences, which may lead to altered transcriptional outputs in host cells. This coincidental finding illustrates both the creative adaptability needed in scientific research and the importance of collaborative efforts across disciplines to uncover new insights. The conversation also delves into Dr. Korb's recent work regarding the histone variant H2BE, initiated by one of her graduate students. She explains how prior research only recognized H2BE's expression in the olfactory system, yet her lab has demonstrated its significant role in regulating synaptic genes and memory formation throughout broader neuronal contexts. Notably, they identified a single amino acid change that influences H2BE's function in chromatin accessibility and gene transcription, emphasizing its potential evolutionary conservation across species. In terms of H2BE's role, Dr. Korb elucidates that its activity is integral in response to extracellular stimuli, particularly within the context of neuronal activation. Intriguingly, they found that H2BE expression decreases in reaction to long-term neuronal stimulation, suggesting a complex mechanism of homeostatic plasticity crucial for regulating neuronal activity levels. This research not only advances understanding of chromatin dynamics but also holds implications for neuronal health and disease mechanisms. References Feierman, E. R., Louzon, S., Prescott, N. A., Biaco, T., Gao, Q., Qiu, Q., Choi, K., Palozola, K. C., Voss, A. J., Mehta, S. D., Quaye, C. N., Lynch, K. T., Fuccillo, M. V., Wu, H., David, Y., & Korb, E. (2024). Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Molecular cell, 84(15), 2822–2837.e11. https://doi.org/10.1016/j.molcel.2024.06.025 Korb, E., Herre, M., Zucker-Scharff, I., Gresack, J., Allis, C. D., & Darnell, R. B. (2017). Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell, 170(6), 1209–1223.e20. https://doi.org/10.1016/j.cell.2017.07.033 Kee, J., Thudium, S., Renner, D. M., Glastad, K., Palozola, K., Zhang, Z., Li, Y., Lan, Y., Cesare, J., Poleshko, A., Kiseleva, A. A., Truitt, R., Cardenas-Diaz, F. L., Zhang, X., Xie, X., Kotton, D. N., Alysandratos, K. D., Epstein, J. A., Shi, P. Y., Yang, W., … Korb, E. (2022). SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature, 610(7931), 381–388. https://doi.org/10.1038/s41586-022-05282-z Feierman, E. R., Paranjapye, A., Su, S., Qiu, Q., Wu, H., & Korb, E. (2024). Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling. bioRxiv : the preprint server for biology, 2024.11.01.620920. https://doi.org/10.1101/2024.11.01.620920 Related Episodes Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats) The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
RFK Jr. Halts $500 Million In mRNA Vaccine Funding, Says Technology Prolonged COVID-19 By Encouraging New Mutations
Congressman Ralph Norman, who is now a candidate for governor of South Carolina, shares his motivations for transitioning from Congress to the gubernatorial race and discusses his vision for the state, including infrastructure improvements, term limits, and combating corruption. Congressman Norman also reflects on the successes of Florida under Governor Ron DeSantis and the need for South Carolina to adopt similar strategies. Dr. Peter McCullough, chief scientific officer at The Wellness Company, discusses the potential links between COVID-19 vaccines and the increase in rapid cancer cases. We explore the implications of messenger RNA technology, the influence of pharmaceutical advertising on medical reporting, and the emerging role of Ivermectin in cancer research. Aaron Withe, CEO of the Freedom Foundation, reveals the troubling trends stemming from the significant influence of teachers unions on American culture and politics. Kasim Khan takes a closer look at the dire situation of his father, former Pakistani Prime Minister Imran Khan, who has been imprisoned under disturbing conditions. Khan shares the harrowing details of his father's incarceration, the struggle for human rights, and the international efforts to secure his release. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
01:00:36 – Danish Study Reversal: Autism Link ConfirmedA Danish vaccine safety study is quietly corrected to reveal a correlation between aluminum and autism—but the researchers refuse media interviews, triggering accusations of deception. 01:13:42 – Gulf Jab Syndrome and COVID InjuriesThe show draws chilling comparisons between unexplained Gulf War illnesses and post-COVID vaccine injuries—calling both the results of reckless, untraceable experimentation. 01:19:36 – Religious Exemptions Under AttackPediatric elites urge the removal of all non-medical vaccine exemptions. The host argues that this represents a merging of medicine and state tyranny. 01:21:08 – The Blasphemy of “Redeemed” Fetal CellsReligious leaders are condemned for claiming vaccines developed with aborted fetal cells are morally acceptable. The host calls this a spiritual betrayal. 01:26:20 – RNA-Sprayed Food: Next Bioengineering ThreatA Moderna spin-off develops RNA pesticides that replicate in crops. The host warns this could embed genetic manipulation directly into the food supply. 02:27:34 – Cops Blame Social Media, Not AttackersThe Cincinnati police chief says social media made the mob beating "look worse than it was." The show mocks this excuse and blasts bystanders for doing nothing while a man was brutally attacked. 02:37:21 – Diversity Doesn't Stop TyrannyCincinnati's first female police chief faces lawsuits for discriminating against white men. The host mocks DEI hires as superficial fixes that don't change the abusive nature of policing. 02:44:26 – UK Internet Crackdown Triggers VPN SurgeBritish citizens scramble for VPNs as the government rolls out harsh age-verification laws. The segment warns that it's less about child safety and more about censorship and digital control. 02:50:10 – Online Safety Act Instantly Used for CensorshipJust hours after going live, the UK law is used to suppress anti-immigration protests. The host says this proves the law was never about safety—just silencing dissent. 02:54:51 – Eric Peters Returns“My first guest as I come back… is Eric Peters… somebody I really respect, who really gets it.” 03:03:02 – Destroy Trust in Institutions“I'm here to destroy trust in institutions. That's my life mission…”Peters declares that blind faith in government institutions must be dismantled—not restored. 03:20:08 – Masculinity, Compliance & Modern MenDiscussion on emasculation, symbolic submission, and how modern clothing and behavior reflect cultural decline. Jordan Peterson is referenced. 03:47:28 – Hidden Worldview in Media“Very subtle philosophy… if you just accept it without looking critically…”Hollywood and media messaging are described as covert tools of cultural transformation. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
01:00:36 – Danish Study Reversal: Autism Link ConfirmedA Danish vaccine safety study is quietly corrected to reveal a correlation between aluminum and autism—but the researchers refuse media interviews, triggering accusations of deception. 01:13:42 – Gulf Jab Syndrome and COVID InjuriesThe show draws chilling comparisons between unexplained Gulf War illnesses and post-COVID vaccine injuries—calling both the results of reckless, untraceable experimentation. 01:19:36 – Religious Exemptions Under AttackPediatric elites urge the removal of all non-medical vaccine exemptions. The host argues that this represents a merging of medicine and state tyranny. 01:21:08 – The Blasphemy of “Redeemed” Fetal CellsReligious leaders are condemned for claiming vaccines developed with aborted fetal cells are morally acceptable. The host calls this a spiritual betrayal. 01:26:20 – RNA-Sprayed Food: Next Bioengineering ThreatA Moderna spin-off develops RNA pesticides that replicate in crops. The host warns this could embed genetic manipulation directly into the food supply. 02:27:34 – Cops Blame Social Media, Not AttackersThe Cincinnati police chief says social media made the mob beating "look worse than it was." The show mocks this excuse and blasts bystanders for doing nothing while a man was brutally attacked. 02:37:21 – Diversity Doesn't Stop TyrannyCincinnati's first female police chief faces lawsuits for discriminating against white men. The host mocks DEI hires as superficial fixes that don't change the abusive nature of policing. 02:44:26 – UK Internet Crackdown Triggers VPN SurgeBritish citizens scramble for VPNs as the government rolls out harsh age-verification laws. The segment warns that it's less about child safety and more about censorship and digital control. 02:50:10 – Online Safety Act Instantly Used for CensorshipJust hours after going live, the UK law is used to suppress anti-immigration protests. The host says this proves the law was never about safety—just silencing dissent. 02:54:51 – Eric Peters Returns“My first guest as I come back… is Eric Peters… somebody I really respect, who really gets it.” 03:03:02 – Destroy Trust in Institutions“I'm here to destroy trust in institutions. That's my life mission…”Peters declares that blind faith in government institutions must be dismantled—not restored. 03:20:08 – Masculinity, Compliance & Modern MenDiscussion on emasculation, symbolic submission, and how modern clothing and behavior reflect cultural decline. Jordan Peterson is referenced. 03:47:28 – Hidden Worldview in Media“Very subtle philosophy… if you just accept it without looking critically…”Hollywood and media messaging are described as covert tools of cultural transformation. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
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