Podcasts about neuronal

Most neural network models till date have assumed all neurons to be identical, or at least that all neurons within a population are identical. In reality, no two neurons are completely the same. Is this due to unavoidable "biological noise" that the nervous system has to cope with, or can it be a useful feature included by design? The guest co-wrote the recent paper "How heterogeneity shapes dynamics and computation in the brain" addressing this question.

Creatine and Microbiomes A new 2026 Cell Metabolism study explores a compelling and increasingly central idea in modern biology: the gut/brain/immune/metabolism axis is not just associative, it is mechanistic. Specifically, Dr. Lu and colleagues investigate how the gut microbiota can directly influence depressive behavior by reshaping systemic and neural metabolism. This is another in a long running list of papers describing the amazing work that bacterial commensal microbes do for us. In this case, our minds and moods. "Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression." "The brain, as an energy-intensive organ, relies on precise metabolic regulation to maintain synaptic plasticity, neurotransmitter synthesis, and stress response systems. Accumulating evidence implicates energy metabolism dysregulation as a hallmark of depression. Neuroimaging studies using positron emission tomography (PET) have identified marked glucose hypometabolism in the medial prefrontal cortex (mPFC) of patients with depression. Cerebral mitochondrial dysfunction and ATP imbalance have been mechanistically linked to depression progression. Notably, emerging studies emphasize the bidirectional interplay between peripheral metabolic signals and central energy regulation, which is fundamental to neural metabolism. Clinical observations such as fatigue, appetite dysregulation, and unexplained weight fluctuations in patients with depression further suggest systemic metabolic disturbances spanning peripheral organs and the CNS.." (Lu et. al. 2026) This is next-level medicine. Mental health can no longer be framed as a disorder of genetics, experience, or circumstance alone. This work opens a clearer window, showing how the microbiome participates as an active partner, shaping brain function through the metabolites it helps produce and deliver. Compounds like creatine are no longer just peripheral players. They become signals, fuel, structure, and information, bridging gut and brain, metabolism and behavior.... and more Enjoy, Dr. M

Un estudio del Journal of Sport and Health Science revela que 150 minutos de ejercicio aeróbico semanal transforman la química cerebral. La investigación con 130 adultos demostró que el movimiento moderado reduce el cortisol, evitando que el estrés crónico reduzca regiones vinculadas a la memoria y protegiendo la estructura física. Escuchar audio

Morgens neuronal, abends LLMex

Welcome to the 35th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with first author Dr Laetitia Marcadet and senior author Chantelle F Sephton of the Brain article entitled: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity. We discuss the interest concept of abnormal cellular energy metabolism in amyotrophic lateral sclerosis and, more broadly, across other neurodegenerative and neurological conditions. The authors outline their combined model of neuronal and, more uniquely, astrocytic compartments to identify response to lipid droplet targeting. Check out the full article on the Brain website as part of the Feb 2026 issue: https://doi.org/10.1093/brain/awaf404 This episode was co-hosted, edited and produced by Roberto Bellanti and Andreas Thermisticleous, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.

# TEMA LABORATORIO NEURONAL : Entender y crear inteligencia

Send us Fan MailIs the fundamental purpose of sleep to remove oxidized fats from the brain?Nick & Dr. Amita Sehgal talk about the latest science on why animals sleep. Using fruit flies, her lab shows that waking generates oxidized lipids in neurons that are shuttled to glia and then cleared by macrophage-like cells during sleep. This process protects mitochondria, supports memory, and links sleep to metabolic cleanup rather than just rest.TOPICS DISCUSSED:Drosophila as a model: Fruit flies sleep with immobility, reduced responsiveness, and homeostatic rebound; their genetics reveal conserved mechanisms found in humans.Circadian vs homeostatic sleep: Circadian timing sets when we sleep; homeostatic drive builds need from prolonged wakefulness independent of time of day.Metabolic waste during wake: Neuronal activity oxidizes lipids in mitochondria; these damaged lipids transfer to glial support cells via apolipoproteins.Immune cells clear brain trash: Macrophage-like hemocytes dock at the brain during sleep, phagocytose oxidized lipids, and remove them; blocking this docking reduces sleep and impairs memory.Peroxisomes & oxidative stress: These organelles handle specific fats and rise with wakefulness; disrupting them increases brain oxidation that can be partially rescued by antioxidants like N-acetylcysteine.Sickness sleep differs from normal sleep: Infection-induced sleep redirects energy to immune defense and depletes rather than restores brain energy stores.ABOUT THE GUEST: Amita Sehgal, PhD is the John Herr Musser Professor of Neuroscience at the University of Pennsylvania, an HHMI Investigator, and director of the Chronobiology and Sleep Institute. She uses Drosophila genetics to uncover basic mechanisms of circadian rhythms and sleep.RELATED EPISODE:M&M 257: Sleep, Mitochondrial Metabolism & Oxidative Stress | Gero MiesenbockSupport the showHealth Products by M&M Partners:SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)For all the ways you can support my efforts

La tertulia semanal en la que repasamos las últimas noticias de la actualidad científica. En el episodio de hoy: -¿Por qué alucinan los LLM? (Continuación) (00:00) -Engranajes que no se tocan (25:40) -El mejor mapa de materia oscura hasta la fecha (49:10) -Cortical Labs pone su sistema con neuronas biológicas DishBrain a jugar al Doom (1:11:40) -Señales de los oyentes (1:48:40) Este episodio es continuación de la Cara A. Contertulios: Juan Carlos Gil, Silvana Tapia, Luisa Achaerandio, Gastón Giribet, Francis Villatoro, Héctor Socas Imagen de portada: NASA. Todos los comentarios vertidos durante la tertulia representan únicamente la opinión de quien los hace... y a veces ni eso

La tertulia semanal en la que repasamos las últimas noticias de la actualidad científica. En el episodio de hoy: Cara A: -Evento cientófilo para ver el eclipse del 12 de Agosto (6:00) -El libro de Gastón: Agujeros negros. De la relatividad general a la información cuántica (14:30) -¿Por qué alucinan los LLM? (28:00) Este episodio continúa en la Cara B. Contertulios: Juan Carlos Gil, Silvana Tapia, Luisa Achaerandio, Gastón Giribet, Francis Villatoro, Héctor Socas Imagen de portada: NASA. Todos los comentarios vertidos durante la tertulia representan únicamente la opinión de quien los hace... y a veces ni eso

The time is now! This week we're discussing how to create your own individual curriculum, an endeavor I happen to have extensive experience with. We will be breaking this series into parts as I want to readjust some understanding, reframe some concepts, and give insight into best practices to maintain longevity. Please have your notebooks out and your listening ears on or just relax tbh (we value personal choice in the communal Schauer) because this refresher will be heavy.  Don't worry, next week will be on creative execution! Make sure to like, subscribe, rate me 5 stars, and follow along, you may learn something new.  Please follow Elizabeth! —> https://www.tiktok.com/@xparmesanprincessx  Resources: Visual Thinking: The Hidden Gifts of People Who Think In Pictures, Patterns, and Abstractions - Temple Grandin  The Data Detective: Ten Easy Rules to Make Sense of Statistics - Tim Harford  This Is What It Sounds Like - Susan Rogers and Ogi Ogas Decisionscape: How Thinking Like an Artist Can Improve Our Decision-Making - Elspeth Kirkman Connections Over Compliance: Rewiring Our Perceptions of Discipline - Lori L. Desautels, PhD Below this is the online powerpoint Slideshow for “Applied Educational Neuroscience/Brain, Adversity and Resiliency https://static1.squarespace.com/static/5ceee1ee9cd4360001a1cfca/t/5d8e307c5a5a131029422a4d/1569599618600/Desautels+PowerPoint.pdf Struggling to Find a Hobby That Sticks? Try a “Personal Curriculum” https://theeverygirl.com/personal-curriculum-tiktok-trend/ How to Start Researching as a Hobby https://substack.com/home/post/p-168506463  How to Be The Type of Person Who Loves Reading and Learning https://substack.com/home/post/p-179871707 How Words Shape Consciousness: New Research Reveals The Deep Link Between Language and Awareness https://thedebrief.org/how-words-shape-consciousness-new-research-reveals-the-deep-link-between-language-and-awareness/  No brain, no gain: Neuronal activity enhances benefits of exercise https://penntoday.upenn.edu/news/no-brain-no-gain-neuronal-activity-enhances-benefits-exercise No Child Left Behind: What Worked, What Didn't https://www.nhpr.org/education/2015-10-27/no-child-left-behind-what-worked-what-didnt  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send a textIn this episode, we're honoured to be re-joined by Professor Amanda Ellison who disced all things about the brain and headaches on episode 92, Splitting: The Inside Story on Headaches Professor Ellison has published more than 80 peer-reviewed papers, earning close to 3,000 citations, with research spanning visual neuroscience, sensorimotor systems, and neuronal disruption in conditions such as migraine and headache disorders. Her work provides valuable insight into how the brain functions—and malfunctions—following injury or dysfunction.Alongside her academic research, Professor Ellison is a passionate science communicator and the author of Getting Your Head Around the Brain and Splitting: The Inside Story on Headaches, two widely respected books that translate complex neuroscience into accessible, real-world understanding.02:00 - The Love for Action Potentials04:20 – What is Neuron and Why are the Special?07:30 – It Does Not Like the Text Book11:00 – What is an Action Potential and What is the Physiology Behind it?24:30 –How Neurons Communicate 29:35 - The Story of Camillo Golgi and Santiago Ramón Cajal 34:35 – Chemical Signals of Action Potentials 43:50 – Mitochondria, ATP and Sodium Potassium Pumps47:00 – Conceptualizing it All54:10 – Fatigue, ATP and mTBI59:00 – Calcium's Role01:08:54 – Favourite Thing About Professor Ellison's WorkGoogle Scholar: https://scholar.google.com/citations?user=-z_DSs4AAAAJ&hl=enSplitting: Inside Story on Headaches (https://www.amazon.com.au/Splitting-Inside-Headaches-Amanda-Ellison/dp/1472971396) Getting Your Head Around The Brain: https://www.amazon.com.au/Getting-your-head-around-brain-ebook/dp/B09HZ9FVSR?ref_=ast_author_dp Subscribe, review and share for new episodes which will drop weekly Social media:Twitter: @first concussionFacebook: Headfirst: A concussion podcastInstagram: Headfirst_ Concussion  Email: headfirstconcussion@gmail.com

Neuronal activity induced by the psychedelic drug strengthens inputs from sensory brain areas and weakens cortico-cortical recurrent loops.

Guest: Dr. Thomas Vierbuchen is Assistant Professor of Developmental Biology at Memorial Sloan Kettering Cancer Center. In this episode, he talks about using PSCs to model neurodevelopmental processes. He also discusses his direct reprogramming work and his lab’s recent study on OTX2 in gastrulation. (42:02) Featured Products and Resources: Submit your abstract for ISSCR 2026! Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling. The Stem Cell Science Round Up Restoring Function After Spinal Cord Injury: In a non-human primate model of spinal injury, researchers grafted ESC-derived spinal cord neural stem cells and improved forelimb function. (2:00) Improving HSC Expansion: Inhibiting ferroptosis augments the expansion of HSCs ex vivo. (11:40) Cardiomyocytes and Macrophage Reprogramming: Injury-induced Clusterin+ cardiomyocytes promote neonatal heart regeneration by reprogramming macrophages. (21:27) Bone Marrow Organoids: A 3D in vitro bone marrow model captures phenotypic, structural, and functional features of human endosteal bone marrow niches. (33:03) Image courtesy of Dr. Thomas Vierbuchen Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer's disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

In the second episode of this three-part series, we delve into the science behind Refractory Chronic Cough (RCC), focusing on the role of neuronal hypersensitivity and how the cough reflex becomes dysregulated.1 Join leading experts as they explain the neurobiology of RCC, discuss the latest research, and share practical insights for identifying RCC in clinical practice.

Dr. Sarah McKay, a brilliant neuroscientist, takes us on a thrilling adventure into the intricate dance between hormones and the female brain during menopause. She shares her personal quest to unravel how those mischievous hormonal shifts tweak women's brains from 40 onwards, revealing the fascinating secrets of neuronal 'pruning and tuning.' Dr. McKay also shines a spotlight on the superstars estrogen, dopamine, and serotonin, and uncovers how our social circles and daily choices play a massive role in brain health. With sparkling discussions on metabolic health and the wider ripple effect of menopause, this episode is a must-listen for any woman eager to keep her brain sparkling and sharp! To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep311 Dr. Sarah McKay is a neuroscientist and science communicator who makes brain science practical and accessible for better health, wellbeing, and performance. She holds an MSc and PhD from Oxford and spent five years researching spinal cord injury before founding Think Brain, her science education company. Sarah's appeared on ABC's Catalyst, The Mel Robbins Podcast, SBS Insight, and has been featured in The Wall Street Journal, The Guardian, and Australian Women's Weekly. She's the author of The Women's Brain Book, Baby Brain, and Brain Health for Dummies, all exploring how understanding the brain can help us live and feel better. Check out our fasting membership at https://esetacademy.drmindypelz.com. Please note our medical disclaimer.

El aprendizaje, la memoria, nuestro sentido del yo, residen en la compleja red de conexiones de las neuronas y el diálogo continuo que mantienen con otras células cerebrales. Entender esos mecanismos no solo es fundamental para conocer el software cerebral… También para comprender que es lo que falla en enfermedades neurológicas como el Alzheimer. Ese el objetivo de Manuel Valero, director del Laboratorio de Computación Neuronal en el Instituto de Investigación Hospital del Mar, a quien hemos entrevistado en el programa. Las aguas termales transportan y depositan minerales, interactúan con las rocas a través de procesos químicos y sirven como indicadores de la actividad geológica subyacente. Ese hidrotermalismo no es exclusivo de la Tierra. También se produce en otros cuerpos celestes y, como nos ha contado Jesús Martínez Frías, también se ha detectado en las muestras del asteroide Bennu traídas a la Tierra por la misión de la NASA Osiris-Rex. Con Jesús Puerta hemos analizado una de las cuestiones que intrigan a los científicos: Por qué en el universo domina la materia si el Big Bang se formó una cantidad similar de antimateria. Y la respuesta está en la simetría de algunas partículas elementales. José Manuel Torralba nos ha hablado del sistema robótico de Inteligencia Artificial A-Lab que produce y analiza materiales sin intervención humana. Este sistema está en comunicación con otro que es capaz de predecir la existencia de cientos de miles de materiales estables, lo que dará al A-Lab un montón de candidatos a los que aspirar en el futuro. María González Dionis nos ha contado el hallazgo de nuevos fósiles de pies y manos del “Hombre cascanueces” (Paranthropus boisei) que revelan que sus manos podían agarrar objetos y manejar herramientas como los humanos primitivos y trepar a los árboles como los gorilas.Escuchar audio

El aprendizaje, la memoria, nuestro sentido del yo, residen en la compleja red de conexiones de las neuronas y el diálogo continuo que mantienen con otras células cerebrales. Entender esos mecanismos no solo es fundamental para conocer el software cerebral… También para comprender que es lo que falla en enfermedades neurológicas como el Alzheimer. Ese el objetivo de Manuel Valero, director del Laboratorio de Computación Neuronal en el Instituto de Investigación Hospital del Mar, a quien hemos entrevistado en el programa. Las aguas termales transportan y depositan minerales, interactúan con las rocas a través de procesos químicos y sirven como indicadores de la actividad geológica subyacente. Ese hidrotermalismo no es exclusivo de la Tierra. También se produce en otros cuerpos celestes y, como nos ha contado Jesús Martínez Frías, también se ha detectado en las muestras del asteroide Bennu traídas a la Tierra por la misión de la NASA Osiris-Rex. Con Jesús Puerta hemos analizado una de las cuestiones que intrigan a los científicos: Por qué en el universo domina la materia si el Big Bang se formó una cantidad similar de antimateria. Y la respuesta está en la simetría de algunas partículas elementales. José Manuel Torralba nos ha hablado del sistema robótico de Inteligencia Artificial A-Lab que produce y analiza materiales sin intervención humana. Este sistema está en comunicación con otro que es capaz de predecir la existencia de cientos de miles de materiales estables, lo que dará al A-Lab un montón de candidatos a los que aspirar en el futuro. María González Dionis nos ha contado el hallazgo de nuevos fósiles de pies y manos del “Hombre cascanueces” (Paranthropus boisei) que revelan que sus manos podían agarrar objetos y manejar herramientas como los humanos primitivos y trepar a los árboles como los gorilas.Escuchar audio

"Im Alter von 0 bis 2 Jahren sollte Bildschirmzeit komplett vermieden werden. Hier sehen wir nachweislich eine Veränderung zum Beispiel in der Entwicklung der Sprache." – Smartphones, Tablets, YouTube, Games, Netflix & Co. – Kinder wachsen heute in einer Dauerverfügbarkeit von Reizen auf. Gleichzeitig steigen Konzentrationsprobleme, Schlafstörungen, motorische Defizite und emotionale Dysbalancen. Doch was passiert biologisch, wenn ein Kind regelmäßig auf einen Screen schaut? Kinder mit Smartphones – ein Thema, das sofort Emotionen weckt. Was macht regelmäßige Bildschirmnutzung im Kinder- und Jugendalter mit Körper, Gehirn und Psyche? Und wie viel ist zu viel? Podcast-Host Felix Moese und Gesundheitswissenschaftler Matthias Baum sind selbst Eltern kleiner Kinder. Die beiden tauchen tief ein in die Welt digitaler Reize und erklären die physiologischen, neurologischen und evolutionsbiologischen Zusammenhänge – jenseits von moralischer Panik, dafür wissenschaftlich fundiert und verständlich. Sie zeigen, wie Bildschirmzeit das kindliche Gehirn beeinflusst, warum das Belohnungssystem überstimuliert wird – und was das für Konzentration, Motivation und emotionale Entwicklung bedeutet. Besonders in den ersten Lebensjahren reagiert das Gehirn sensibel auf Reize – digitale Überforderung kann die neuronale Verschaltung langfristig verändern. Ein weiterer Schwerpunkt: der Zusammenhang zwischen Licht, Melatonin und Schlaf – und warum abendliches Scrollen nicht nur Kinder künstlich wach hält. Außerdem sprechen Felix und Matthias über die psychologischen Folgen von Social Media: den Vergleich mit anderen, den ständigen Dopamin-Kick – und warum das Risiko für ADHS-ähnliche Symptome steigt (übrigens auch bei Erwachsenen). Wie immer bleibt es nicht bei der Analyse: Felix und Matthias geben Orientierung für den Alltag. Sie zeigen konkrete Wege, wie Eltern ihre Kinder begleiten können, um digitale Kompetenz zu fördern statt Verbote auszusprechen. Mit praktischen Tipps – vom Co-Viewing bis zu klaren Offline-Zeiten. Am Ende steht die Erkenntnis: Digitale Medien sind weder gut noch böse. Entscheidend ist, wie bewusst wir sie nutzen – und ob Kinder noch genug Raum haben für das, wofür ihr Gehirn evolutionär vorgesehen ist: Bewegung, Begegnung und Erlebnisse in der realen Welt. HEALTH NERDS – Mensch, einfach erklärt. Ein ALL EARS ON YOU Original Podcast.

In this podcast, Alessandro Simonati discusses his paper 'Age at onset and gene variants predict lifespan and disease duration in childhood neuronal ceroid lipofuscinoses'.   The paper is available here: https://doi.org/10.1111/dmcn.16416   Follow DMCN on Podbean for more:  https://dmcn.podbean.com/ ___ Watch DMCN Podcasts on YouTube: https://bit.ly/2ONCYiC __ DMCN Journal: Developmental Medicine & Child Neurology (DMCN) has defined the field of paediatric neurology and childhood-onset neurodisability for over 60 years. DMCN disseminates the latest clinical research results globally to enhance the care and improve the lives of disabled children and their families.   DMCN Journal - https://onlinelibrary.wiley.com/journal/14698749 ___ Find us on Twitter! @mackeithpress - https://twitter.com/mackeithpress

La neurocientífica Liset Menéndez de la Prida investiga en el Instituto Cajal cómo nuestro cerebro es capaz de recordar el camino a casa, encontrar la salida de una habitación u organizar los recuerdos a lo largo del tiempo. Pere Estupinyà y Javier Sampedro charlan con ella en esta interesantísima conversación sobre el estudio de la actividad neuronal y la construcción mental del tiempo.

Moderator: James Rathmell, M.D. Participants: Shiqian Shen, M.D. and Cyrus David Mintz, M.D., Ph.D. Articles Discussed: Hippocampal Neural Dynamics and Postoperative Delirium-Like Behavior in Aged Mice Neural Network Dynamics of Postoperative Delirium: is it all About Neurons Striking the Right Balance? Transcript

In this episode of the Epigenetics Podcast, we talked with Erica Korb from the University of Pennsylvania about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. Dr. Korb discusses the focus of her lab, which centers on epigenetic mechanisms impacting gene regulation in neurons. Her research primarily examines histone biology and its connection to neurodevelopmental disorders, including autism spectrum disorder and intellectual disabilities. Dr. Korb expounds on the collaborative environment at UPenn's Epigenetics Institute, emphasizing how the rich diversity of research topics fosters innovative ideas and projects within the community. Reflecting on her earlier work from her postdoctoral studies, Dr. Korb discusses her first significant findings regarding the protein BRD4. This work demonstrated BRD4's role in mediating transcriptional regulation crucial for learning and memory processes. She explains how disrupting this protein's function in neurons hindered critical gene activations required for memory formation in mice. This foundational understanding opened avenues for exploring the broader implications of chromatin regulation in various neurodevelopmental conditions. Transitioning into her current research endeavors, Dr. Korb reveals how she aims to expand her focus beyond Fragile X syndrome. With her lab now investigating multiple chromatin regulators implicated in various forms of autism spectrum disorders, she describes a recent project where RNA sequencing exposed substantial overlaps in gene expression changes associated with five distinct chromatin modifiers, each contributing uniquely to neuronal function while collectively demonstrating sensitivity to chromatin disruptions. A significant portion of the discussion centers around Dr. Korb's unexpected exploration into how COVID-19 intersects with chromatin biology through a phenomenon known as histone mimicry. Leveraging bioinformatic tools during the pandemic, her lab discovered that certain viral proteins mimic histone sequences, which may lead to altered transcriptional outputs in host cells. This coincidental finding illustrates both the creative adaptability needed in scientific research and the importance of collaborative efforts across disciplines to uncover new insights. The conversation also delves into Dr. Korb's recent work regarding the histone variant H2BE, initiated by one of her graduate students. She explains how prior research only recognized H2BE's expression in the olfactory system, yet her lab has demonstrated its significant role in regulating synaptic genes and memory formation throughout broader neuronal contexts. Notably, they identified a single amino acid change that influences H2BE's function in chromatin accessibility and gene transcription, emphasizing its potential evolutionary conservation across species. In terms of H2BE's role, Dr. Korb elucidates that its activity is integral in response to extracellular stimuli, particularly within the context of neuronal activation. Intriguingly, they found that H2BE expression decreases in reaction to long-term neuronal stimulation, suggesting a complex mechanism of homeostatic plasticity crucial for regulating neuronal activity levels. This research not only advances understanding of chromatin dynamics but also holds implications for neuronal health and disease mechanisms.   References Feierman, E. R., Louzon, S., Prescott, N. A., Biaco, T., Gao, Q., Qiu, Q., Choi, K., Palozola, K. C., Voss, A. J., Mehta, S. D., Quaye, C. N., Lynch, K. T., Fuccillo, M. V., Wu, H., David, Y., & Korb, E. (2024). Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Molecular cell, 84(15), 2822–2837.e11. https://doi.org/10.1016/j.molcel.2024.06.025 Korb, E., Herre, M., Zucker-Scharff, I., Gresack, J., Allis, C. D., & Darnell, R. B. (2017). Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell, 170(6), 1209–1223.e20. https://doi.org/10.1016/j.cell.2017.07.033 Kee, J., Thudium, S., Renner, D. M., Glastad, K., Palozola, K., Zhang, Z., Li, Y., Lan, Y., Cesare, J., Poleshko, A., Kiseleva, A. A., Truitt, R., Cardenas-Diaz, F. L., Zhang, X., Xie, X., Kotton, D. N., Alysandratos, K. D., Epstein, J. A., Shi, P. Y., Yang, W., … Korb, E. (2022). SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature, 610(7931), 381–388. https://doi.org/10.1038/s41586-022-05282-z Feierman, E. R., Paranjapye, A., Su, S., Qiu, Q., Wu, H., & Korb, E. (2024). Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling. bioRxiv : the preprint server for biology, 2024.11.01.620920. https://doi.org/10.1101/2024.11.01.620920   Related Episodes Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats) The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

No sabemos qué está pasando pero tampoco queríamos saltearnos esta fecha tan especial.

¡¡NUEVO PODCAST!!Dr. Eduardo Calixto…. “Autismo, TDAH y dislexia: origen neuronal”Luis Ignacio Santibáñez  y  Alexis Santibáñez…   “Papá e Hijo, el Podcast”Rodolfo Cadena Labrada… “Julio, el mes  de Frida”Armando Alberto León “El Salsariachi…  “Clásicos de Siempre”                                                                                                                       (Prince Royce y Enrique Guzmán)  

Astrocytes serve as crucial mediators of neuromodulatory processes previously attributed to direct communication between neurons, four new studies show.

www.mundofuturo.vip No podemos predecir el futuro pero sí podemos explorarlo. Jorge Alor, Mario Valle y Jaime Limón analizan las tendencias de tecnología e innovación que cambiarán al mundo en los próximos 10 años más de lo que ha cambiado en los últimos 100. /// Jorge Alor | @elpadrino Mario Valle | @bilbeny Jaime Limón | @mrlemon /// Learn more about your ad choices. Visit megaphone.fm/adchoices

En un mundo donde la velocidad del cambio supera nuestra capacidad de adaptación, entender cómo funciona el cerebro humano se ha convertido en una ventaja competitiva real para las empresas. El neuromanagement —o gestión basada en principios de neurociencia— no es una moda pasajera, sino una nueva forma de liderar desde el conocimiento científico del comportamiento humano. Esta disciplina propone algo tan disruptivo como lógico: alinear el funcionamiento del cerebro con la gestión empresarial para tomar mejores decisiones, liderar con más consciencia y crear organizaciones más resilientes.

¡¡ NUEVO PODCAST ‼ -Dr. Eduardo Calixto… “Ejercitarnos para mejorar la Conexión Neuronal”-Dr. Nathan Mansbach… “Yoga de la Risa: Día Mundial de la Risa (domingo 4 de mayo)”-Dra. Nelly Cecilia Capetillo Ventura. “Día Internacional contra el Bullying” (Acoso Escolar)-José Luis Cuevas (El Pintor)... Pelea del “Canelo” Álvarez contra el cubano William Scull-Héctor Ortiz… “Tributo a Jim Morrison y The Doors”    

A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.

Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

-Dr. Eduardo Calixto… La plasticidad neuronal que genera la proteína: BDNF.-Dr. Jorge Antonio Torres Martínez…Insuficiencia Venosa Crónica y Microangiopatia Diabética… ¿Qué relación guardan ambas enfermedades?- Gaby Pérez Islas… El duelo por los desaparecidos.-María Filippini. Actriz, cantante y bailarina… Reconocimiento a su trayectoria en el Teatro Silvia Pinal // Obra: La Chica del Bikini Azul.  

X y Elon Musk son noticia con el lanzamiento de Grok 3, un modelo de IA integrado en la red social que permite, entre otras cosas, monitorizar tendencias y la escucha social a través del seguimiento de la red. OpenAI lanza su nuevo modelo 4,5, un modelo que aventuramos puede ser clave en el desarrollo de algunas tecnologías emergentes... y Meta compite con Neuralink con una tecnología no invasiva que permite leer los pensamientos.

X y Elon Musk son noticia con el lanzamiento de Grok 3, un modelo de IA integrado en la red social que permite, entre otras cosas, monitorizar tendencias y la escucha social a través del seguimiento de la red. OpenAI lanza su nuevo modelo 4,5, un modelo que aventuramos puede ser clave en el desarrollo de algunas tecnologías emergentes... y Meta compite con Neuralink con una tecnología no invasiva que permite leer los pensamientos.

In this episode, we explore the alarming development of lab-grown human brain tissue that is being harnessed to operate machinery, play video games, and potentially more. Researchers are pushing the boundaries of biotechnology by cultivating miniature, functional clusters of neurons capable of interfacing with external devices. We also delve into Orchestrated Objective Reduction (Orch-OR), a theory of consciousness proposing that self-awareness arises from quantum-level processes within neuronal microtubules. Together, these cutting-edge topics raise profound questions about the nature of intelligence, the ethics of creating and using living brain matter, and the very foundations of conscious experience.

Neuronal and non-neuronal cells throughout the brain also express genes—particularly those related to neuronal structure and immune function—differently in aged mice, according to a new atlas.

In today's episode, we dive into the critical role of phospholipids in maintaining brain health, examining how these molecules contribute to neuronal communication, synaptic plasticity, and cognitive resilience. We'll explore the biochemical structure and function of key phospholipids like phosphatidylserine and phosphatidylcholine within neuronal membranes, where they play indispensable roles. We discuss associations and impacts of environmental toxins, aging, and neurodegenerative conditions. Finally, we discuss dietary tools to support phospholipid levels and promote cognitive health. Topics: 1. Introduction to Phospholipids and Cognitive Health 2. Brain Cell Structure and Composition - Neurons, glial cells. 3. Detailed Anatomy of Neurons - Soma contains organelles, dendrites receive signals, axon sends impulses. - Myelin sheath insulates axon, speeding signal transmission. - Myelin is rich in phospholipids. 4. Roles of Glial Cells in Brain Health - Astrocytes, oligodendrocytes, and microglia support neurons. - Glial cells regulate the brain's environment, form myelin, and provide immune defense. - Phospholipid-rich membranes are essential for glial function. 5. Biochemistry: Phospholipids - Phospholipids have a glycerol backbone, fatty acid tails, and a phosphate group. - Hydrophilic and hydrophobic parts form bilayers. - Key phospholipids: PC, PE, PS, PI 6. Phospholipid Bilayer's Role in Neuronal Communication - Ion channels, receptors, and transporters in the bilayer enable cell functions. - Ion channels allow ions to flow, creating signals for neuron communication. - Receptors detect neurotransmitters, initiating responses. 7. Neuronal Activation and Electrochemical Gradients - Resting neurons have ion concentration differences inside and outside the cell. - Ion channel activity during activation creates an action potential. - The phospholipid membrane enables controlled ion flow for signal transmission. 8. Neurotransmitter Release - Action potential at axon terminal triggers calcium entry. - Calcium causes vesicles to release neurotransmitters. - Released neurotransmitters bind to receptors, continuing the signal. 9. Diversity of Phospholipids in Neuronal Membranes - Different phospholipids (PC, PE, PS, PI) are essential for membrane integrity. 10. Summary: Phospholipids in Brain Function and Cognitive Health - Phospholipids support neuronal communication, synaptic plasticity, and cognitive resilience. - Synaptic plasticity - essential for learning and memory. 11. Phospholipid Disruption and Cognitive Decline - Oxidative stress, aging, and inflammation disrupt phospholipid composition. - Lipid peroxidation damages membranes, affecting neuron signaling. - Phospholipid damage contributes to cognitive decline. 12. Importance of Phospholipids in Aging and Brain Health - Lipid levels decrease with age, impacting brain function. 13. Environmental Toxins and the Brain - Heavy metals like mercury cause oxidative damage to phospholipids. - Damaged phospholipids and impaired neuron function. 14. Consequences of Suboptimal Phospholipids - Cognitive symptoms. - Low levels seen in neurodegenerative conditions. 15. Tools for Supporting Phospholipid Levels - Foods with PS and PC, such as fatty fish and eggs. - Phospholipid supplements. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Dr. Joscha Bach discusses advanced AI, consciousness, and cognitive modeling. He presents consciousness as a virtual property emerging from self-organizing software patterns, challenging panpsychism and materialism. Bach introduces "Cyberanima," reinterpreting animism through information processing, viewing spirits as self-organizing software agents. He addresses limitations of current large language models and advocates for smaller, more efficient AI models capable of reasoning from first principles. Bach describes his work with Liquid AI on novel neural network architectures for improved expressiveness and efficiency. The interview covers AI's societal implications, including regulation challenges and impact on innovation. Bach argues for balancing oversight with technological progress, warning against overly restrictive regulations. Throughout, Bach frames consciousness, intelligence, and agency as emergent properties of complex information processing systems, proposing a computational framework for cognitive phenomena and reality. SPONSOR MESSAGE: DO YOU WANT WORK ON ARC with the MindsAI team (current ARC winners)? MLST is sponsored by Tufa Labs: Focus: ARC, LLMs, test-time-compute, active inference, system2 reasoning, and more. Future plans: Expanding to complex environments like Warcraft 2 and Starcraft 2. Interested? Apply for an ML research position: benjamin@tufa.ai TOC [00:00:00] 1.1 Consciousness and Intelligence in AI Development [00:07:44] 1.2 Agency, Intelligence, and Their Relationship to Physical Reality [00:13:36] 1.3 Virtual Patterns and Causal Structures in Consciousness [00:25:49] 1.4 Reinterpreting Concepts of God and Animism in Information Processing Terms [00:32:50] 1.5 Animism and Evolution as Competition Between Software Agents 2. Self-Organizing Systems and Cognitive Models in AI [00:37:59] 2.1 Consciousness as self-organizing software [00:45:49] 2.2 Critique of panpsychism and alternative views on consciousness [00:50:48] 2.3 Emergence of consciousness in complex systems [00:52:50] 2.4 Neuronal motivation and the origins of consciousness [00:56:47] 2.5 Coherence and Self-Organization in AI Systems 3. Advanced AI Architectures and Cognitive Processes [00:57:50] 3.1 Second-Order Software and Complex Mental Processes [01:01:05] 3.2 Collective Agency and Shared Values in AI [01:05:40] 3.3 Limitations of Current AI Agents and LLMs [01:06:40] 3.4 Liquid AI and Novel Neural Network Architectures [01:10:06] 3.5 AI Model Efficiency and Future Directions [01:19:00] 3.6 LLM Limitations and Internal State Representation 4. AI Regulation and Societal Impact [01:31:23] 4.1 AI Regulation and Societal Impact [01:49:50] 4.2 Open-Source AI and Industry Challenges Refs in shownotes and MP3 metadata Shownotes: https://www.dropbox.com/scl/fi/g28dosz19bzcfs5imrvbu/JoschaInterview.pdf?rlkey=s3y18jy192ktz6ogd7qtvry3d&st=10z7q7w9&dl=0

En Ivoox puedes encontrar sólo algunos de los audios de Mindalia. Para escuchar las 4 grabaciones diarias que publicamos entra en https://www.mindaliatelevision.com. Si deseas ver el vídeo perteneciente a este audio, pincha aquí: https://www.youtube.com/watch?v=E82ZKNv6rv0&t=2s En este encuentro hablaremos sobre los Estados de Ánimo que encontramos en la sociedad en estos tiempos intensos y cuál es la respuesta emocional y mental a todo lo que se está planteando para la Humanidad. También hablaremos de la parte biológica y los procedimientos que pueden ser de ayuda para apoyar a las personas a recuperar su centro. Alana Messineo Asesora en Bienestar Integral y Creación de Realidad. Formadora de Terapeutas en Desprogramación Neuronal. Elena Perea Nutricionista Ortomolecular. Especialista en tratamiento de candidiasis crónica, problemas digestivos e intestinales, hipotiroidismo y problemas hormonales a través de cambios en la dieta y suplementación natural. https://www.nutricionholistica.es/qui... / elenapereanutricionista https://www.elportaldealana.com https://t.me/+B1BUGT-hyoAxZTE0 Infórmate de todo el programa en: https://www.mindalia.com/television/ **CON PREGUNTAS AL FINAL DE LA CONFERENCIA PARA RESOLVER TUS DUDAS *** Si te parece interesante.... ¡COMPÁRTELO!! :-) ------------INFORMACIÓN SOBRE MINDALIA----------DPM Mindalia.com es una ONG internacional sin ánimo de lucro. Nuestra misión es la difusión universal de contenidos para la mejora de la consciencia espiritual, mental y física. -Apóyanos con tu donación en este enlace: https://streamelements.com/mindaliapl... -Colabora con el mundo suscribiéndote a este canal, dejándonos un comentario de energía positiva en nuestros vídeos y compartiéndolos. De esta forma, este conocimiento llegará a mucha más gente. - Sitio web: https://www.mindalia.com - Facebook: / mindalia.ayuda - Instagram: / mindalia_com - Twitch: / mindaliacom - Vaughn: https://vaughn.live/mindalia - Odysee: https://odysee.com/@Mindalia.com *Mindalia.com no se hace responsable de las opiniones vertidas en este vídeo, ni necesariamente participa de ellas. *Mindalia.com no se responsabiliza de la fiabilidad de las informaciones de este vídeo, cualquiera sea su origen. *Este vídeo es exclusivamente informativo.

Medita, piensa y encuentra la salida de esa cárcel, del sueño….

In this episode, we explore the intricacies of neuronal communication, delving into how neurons transmit signals through synaptic connections using neurotransmitters like glutamate and GABA. We also examine the effects of neurotoxins, such as heavy metals and environmental pollutants, on these critical synaptic pathways, leading to cognitive and neurological impairments. Lastly, we discuss neuroprotective strategies to mitigate neurotoxin exposure and promote optimal brain health. Topics: 1. Overview of Brain Cell Anatomy - Types of brain cells: neurons and glial cells. - Structure of neurons: - Soma (cell body): contains nucleus and organelles. - Dendrites: receive signals from other neurons. - Axon: transmits electrical impulses away from the soma. - Synaptic terminals: form synapses with target cells. 2. Neuronal Communication - Synapse structure: - Presynaptic terminal. - Synaptic cleft. - Postsynaptic membrane. - Neurotransmitters: - Role in neuronal communication. - Excitatory neurotransmitters (e.g., glutamate). - Inhibitory neurotransmitters (e.g., GABA). 3. Summary of Neuronal Communication - Recap of excitatory and inhibitory neurotransmitters. - Importance of maintaining proper neuronal communication. 4. Neurotoxins and Their Effects - Types of neurotoxins: - Heavy metals (e.g., lead, mercury, arsenic, cadmium, aluminum). - Chemical neurotoxins (e.g., organophosphates, solvents). - Biological toxins (e.g., mycotoxins). - Environmental pollutants (e.g., PCBs, dioxins). - Mechanisms of neurotoxin damage: - Disruption of neurotransmitter release. - Impairment of receptor function. - Interference with ion channel operation. 5. Example: Mercury's Impact on Cognitive Function - Pathway of mercury exposure and accumulation in the brain. - Disruption of calcium homeostasis and synaptic transmission. - Resulting cognitive impairments. 6. Strategies to Reduce Neurotoxin Exposure - Nutrition: - Opting for organic produce. - Washing produce properly. - Avoiding MSG and aspartame. - Limiting aluminum exposure (baking powder). - Evaluating cookware. - Avoiding farmed salmon. - Water and air quality: - Using water filtration to remove fluoride. - Choosing fluoride-free toothpaste. - Improving air quality and mold remediation. - Using air-purifying plants (e.g., aloe vera, English ivy). - Reducing exposure to places with highly-concentrated neurotoxic chemicals (e.g., nail salons). Thank you to our episode sponsor: ⁠⁠⁠Tremetes, LLC⁠ Use code CHLOE15 to get 15% off ⁠Tremetes' Turkey Tail⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Glioma synapses recruit mechanisms of adaptive plasticity (Nature) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

All of us have the power and choice to re-architect the structure of our brain to be healthier, happier and of greater service. Discussed in this fascinating interview episode with award winning author & TED Talk speaker, Shauna Shapiro, are the differences between meditation and mindfulness, empathy and compassion, and how to leverage all of these concepts into our day-to-day lives. To embody practices, we have to understand them and science helps us with this. You will learn in this episode: How what you practice grows Why your attention is your greatest currency  How the understanding of neuroplasticity in science has changed everything How mindfulness and meditative practices positively impact every sector of your life The difference between meditation and mindfulness (because they are different!) How these practices make you a better citizen and family member Why compassion is more advantageous than empathy  Why compassion for yourself is crucial  SHOW NOTES: The art of attention is discussed. Your attention is your greatest currency. Your attention implicates every arena of your life: the quality of your  Neuroplasticity is the capacity at any age to reconfigure our brain and its thought patterns. How to rewire your mind: Neuroplasticity & spirituality   All of us have the power and choice to re-architect the structure of our brain to be healthier, happier to be of greater service. What we practice grows stronger both for the good and for the bad.  Neuronal pruning concepts are detailed such as pruning neural pathways. Every time you go on new pathway it prunes automatically prunes the old pathway  Difference between meditation and mindfulness is broken down. They are distinct and separate things that support each other. Meditation is the practice and exercise so we can grow mindfulness. It's going to the gym, so we can grow our mindfulness which is a state, a way of being and a way of paying attention. Attention is your most valuable resource. Ask yourself, can I be present? On average a Harvard study shows, our minds wander 47% of the time! So most of us are missing pretty much half our lives. Meditation is part of practice so we can grow our mindfulness in moment-to-moment life. This model of mindfulness is detailed with clear steps to use.  Many people feel they can't meditate.  The many benefits of meditation are discussed. So many of us don't feel worthy of taking time to care for ourselves. These practices are self-love practices.People who practice mindfulness and meditation are better citizens of the world. The myth that meditation and mindfulness practices are selfish is debunked with science.They make people more generous and more compassionate. There is data to prove this. The science is very compelling.  The convergence and confluence of the feelings of compassion and empathy are broken down. To embody practices, we have to understand them and science helps us with this. The ways that empathy and compassion work in our brain are discussed and then how to leverage these feelings in impactful ways are detailed. The Tibetan definition of compassion is considered incomplete if it does not include ourselves. Furthermore, a compassionate act that is not healthy for you, is not even considered compassion. ✨HUGE ANNOUNCEMENT!:  The doors for the Modern Mystic Membership are now open! Monthly Mystic Members get access to a library of over 100 tantric yoga, meditation & breathwork classes as well as short “Mystic Hack” videos which have topics including astrology, tarot cards, developing psychic abilities, grounding/protecting/growing your energy and more! Sampling of FREE videos on the elegant Mystic Membership platform:  modernmystic.love ✨I offer profound psychic medium readings modernmystic.love ✨I offer one-on-one  Soul Psyche Mapping Astrology Readings. Book via (*This includes a copy of your birth chart and an audio recording of the session) modernmystic.love ✨Give it a 5 star, 1 line review on Apple Music (takes literally 2 min either from an iPhone or via the Apple Music store on all other devices) or on Spotify. This is HUGE as it helps get it heard more which supports the podcast. ✨Join conscious conversation & community in the Modern Mystic Podcast Private F-book Group: https://www.facebook.com/groups/959629444823656/ ✨Get inspiring insights on IG: @modernmysticlove @mystickilkenny

Today, I am blessed to have here with me Dr Chris Palmer. He received his medical degree from Washington University School of Medicine and did his internship and psychiatry residency at McLean Hospital, Massachusetts General Hospital, and Harvard Medical School. Dr. Palmer leads McLean Hospital's Department of Postgraduate and Continuing Education. In this role, he has developed hundreds of educational conferences, workshops, Grand Rounds, and other professional educational activities, most of them under the aegis of Harvard Medical School. His leadership has transformed the department from a small, subsidized department of the hospital into a flourishing educational program that is now leading mental health education for professionals nationwide. He has held numerous leadership positions in the continuing education field beyond McLean Hospital's program, including serving on leadership, advisory, and strategic planning committees of Harvard Medical School, Partners Healthcare, the Massachusetts Medical Society, and the Accreditation Council for Continuing Medical Education (ACCME). In this episode, Dr. Palmer will delve into various topics including nicotine's effects on mitochondrial function, the cell danger response and its relationship with mitochondria, the impact of stressors on mitochondrial responses, variations in mitochondrial responses among different tissues and cell types, and the concept of energy allocation and optimization within the body's systems. Tune in as we chat about the relationship of Ketogenic Diet and overall health. Join my 90 day heavy metals detox program (6 spots left) http://www.ketokampdetox.com  Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [03:22] The Transformative Power of the Ketogenic Diet in Mental Health Long-term adherence to a ketogenic diet can lead to significant health improvements. The ketogenic diet has shown potential in improving mental health conditions such as schizophrenia and bipolar disorder. Weight loss goals can serve as a powerful motivator for individuals with mental health challenges to embark on dietary changes. The ketogenic diet has the potential to reduce symptoms such as hallucinations, delusions, and paranoia in certain individuals. The success of the ketogenic diet in mental health has sparked scientific research and clinical trials, positioning it as a promising approach in the field of neuroscience. [13:08] Mitochondria: Its Intricate Role in Mental Health Mitochondria, often known as the powerhouse of the cell, have far-reaching functions beyond energy production. Mitochondria play critical roles in the functioning of cells, including tasks relevant to mental health. High mitochondrial concentration is observed at synapses, the communication points between neurons. Mitochondria actively contribute to neurotransmitter release and the restoration of ion gradients at synapses. Disruption of mitochondrial function at synapses can impair neurotransmitter release and impact mental health. [21:16] Mitochondrial Dysfunction and Dietary Impact on Health Mitochondrial dysfunction, characterized by oxidative stress, can lead to cell death. The standard American diet high in processed carbs and seed oils may contribute to mitochondrial dysfunction. Adopting a low-carb, high-fat ketogenic diet or practicing fasting can stimulate mitochondrial adaptation and improvement. Fasting and ketogenic diet trigger autophagy, a process that removes defective proteins and promotes cellular renewal. Mitochondrial biogenesis occurs during fasting or a ketogenic diet, leading to an increase in healthy mitochondria and potentially benefiting both metabolic and mental health. [29:20] Mitochondrial Dysfunction and Neuronal Vulnerability Malfunctioning mitochondria struggle to process fuel sources, leading to insufficient ATP production and cellular dysfunction. Glycolysis becomes the alternative energy pathway in cells with dysfunctional mitochondria, resulting in lactic acid buildup and further impairments. Excessive reactive oxygen species exacerbate the cellular struggles, leading to apoptosis in most cells but posing challenges in neurons. Neurons lack programmed cell death (apoptosis) and rely on protective mechanisms, making them highly vulnerable to oxidative stress. Neuronal death and shrinkage can contribute to neurodegenerative disorders like Alzheimer's and Parkinson's disease. [50:14] Nicotine's Effects on Mitochondria and the Cell Danger Response Nicotine, as a stimulant, can enhance mitochondrial function in low doses, potentially improving mood, cognition, and memory. Pure nicotine can be beneficial if used appropriately and in moderation, but excessive use or underlying health issues can lead to harm. Mitochondria play a role in the cell danger response, where they adjust energy production based on perceived threats, such as infections or stressors. Mitochondrial responses to stressors vary among different tissues and cell types, with some increasing energy production and others reducing it. The body constantly reallocates energy resources to optimize overall function, guided by complex coordination between cells, mitochondria, and the nervous system. AND MUCH MORE! Resources from this episode:  Website: https://www.chrispalmermd.com/  Get Dr Palmer's brand new book Brain Energy here: https://amzn.to/3ppQQCH Free Newsletter: https://brainenergy.com/  Follow Dr Palmer Facebook: https://www.facebook.com/ChrisPalmerMD/  Twitter: https://twitter.com/ChrisPalmerMD/  YouTube: https://www.youtube.com/@chrispalmermd4244  Instagram: https://www.instagram.com/chrispalmermd/  Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Join my 90 day heavy metals detox program (6 spots left) http://www.ketokampdetox.com  FREE DETOX TRAINING: https://www.ketokamp.com/Detox-Masterclass Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.