Podcasts about keima

BUFFALO, NY- June 17, 2024 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, “Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration.” Mitophagy is a selective form of autophagy which permits the removal of dysfunctional or excess mitochondria. This occurs as an adaptative response to physiological stressors, such as hypoxia, nutrient deprivation, or DNA damage. Mitophagy is promoted by specific mitochondrial outer membrane receptors, among which are BNIP3 and BNIP3L. The role of mitophagy in cancer is being widely studied, and more specifically in the maintenance of cancer stem cell (CSC) properties, such as self-renewal. Given that CSCs are responsible for treatment failure and metastatic capacity, targeting mitophagy could be an interesting approach for CSC elimination. In this new study, researchers Marta Mauro-Lizcano, Federica Sotgia, and Michael P. Lisanti from the University of Salford describe a new model system to enrich sub-populations of cancer cells with high basal levels of mitophagy, based on the functional transcriptional activity of BNIP3 and BNIP3L. “Briefly, we employed a BNIP3(L)-promoter-eGFP-reporter system to isolate cancer cells with high BNIP3/BNIP3L transcriptional activity by flow cytometry (FACS).” The model was validated by using complementary lysosomal and mitophagy-specific probes, as well as the mitochondrially-targeted red fluorescent protein (RFP), namely mt-Keima. High BNIP3/BNIP3L transcriptional activity was accompanied by increases in i) BNIP3/BNIP3L protein levels, ii) lysosomal mass, and iii) basal mitophagy activity. Furthermore, cancer cells with increased BNIP3/BNIP3L transcriptional activity exhibited CSC features, such as greater mammosphere-forming ability and high CD44 levels. “To further explore the model, we also analysed other stemness characteristics in MCF7 and MDA-MB-231 breast cancer cell lines, directly demonstrating that BNIP3(L)-high cells were more metabolically active, proliferative, migratory, and drug-resistant, with elevated anti-oxidant capacity. Therefore, high levels of basal mitophagy appear to enhance CSC features.” DOI - https://doi.org/10.18632/aging.205939 Corresponding authors - Federica Sotgia - fsotgia@gmail.com, and Michael P. Lisanti - michaelp.lisanti@gmail.com Video short - https://www.youtube.com/watch?v=n872jCkc-q8 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205939 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer's disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Behold oh divine ones the sickest of pickup artist tricks based solely on video game logic. That idea seems offensive on its face, but what if I was to tell you it's surprisingly charming and wholesome. That is the balance the guys try to reach when tackling the romance harem comedy known as The World Only God Knows. How can a show with such an unlikeable main character make us smile, well for starters the cutest little demon sister that makes us all scream ONII-CHAN! Why does Keima look like Austin Powers? Why does hell use incels for their important soul capturing work? Is bread filled with Soba noodles any good? We try to find out all this and more as we look to find the perfect ending ::pushes up glasses:: Follow us on Twitter @weeb_noob Follow us on Instagram @wanwapodcast --- Support this podcast: https://anchor.fm/wanwapodcast/support

Keima Sinclair shares her testimony from her new book Tested, Tried, But I Survived

Keima Sinclair and Kimberly Moses discuss their new book, "All Things Relationships"

In this week’s episode PrimaDiva talks about her producing class’ crowdfunding campaign for a feature film called Stay With Me, focusing on a young woman suffering from borderline personality disorder. We discuss the importance of mental health advocacy, and different anime that deal with Otakus and the depression protagonists like Subaru in re:Zero and Keima in The World Only God Knows have to overcome.

Iris Barcia is an innovative technologist and experienced telecommunications professional, we are delighted to welcome her this week. Iris explains how technological curiosity and innovation drove her career, and set her on the road to becoming a leading telecommunications professional. Iris entertains us with her start-up journey and her creative role at Keima. 

Keima Katsuragi is a hardcore gamer of dating sims whose world is turned inside out after he accidentally accepts a contract from a demon. Elsie enlists Keima to help her capture loose souls hiding within the emptiness of girls' hearts, requiring Keima to apply the romancing skills he's developed in the 2D world in real life. Quite a bit of disagreement over this review, see where we land! Go find us on social media! We want to hear from you! Follow the official account on Twitter (@sequencepod). You can also find us on; Vince (@vincekenny), Kym (@kymcattys) and Ben(@benstonick) Or! Drop us an email address with transformationsequence@gmail.com You can listen to Transformation sequence on Stitcher, too! http://www.stitcher.com/podcast/transformation-sequence

Durch ein Missverständnis hat sich der smarte Otaku und Dating-Game-Gott Keima dazu verpflichtet, für Teufelin Elsea die Herzen unschuldiger Mädchen zu erobern. Denn dieser sind Fluchtgeister aus der Hölle entwischt, die sich nun in Mädchenherzen verstecken. Nur, wenn sich die Mädchen in Keima verlieben, öffnen sich ihre Herzen und der Geist kann gefangen werden. Keima bleibt keine andere Wahl, als den Casanova zu mimen … Diese Comedy-Slapstick-Reihe voller genialer Fälle und Eroberungstaktiken, die auch im echten Leben funktionieren von Tamiki Wakaki ist mit denen des Hit-Autors Ken Akamatsu vergleichbar.

Programa número 18 de Mal Vivir, emitido el 21 de abril de 2014, programa donde hablamos del final del manga de Kami Nomi zo Shiru Sekai, el extraño y apresurado final que se le dio, la ausencia de esperanzas en el futuro y opiniones sobre la chica elegida por Keima, también desvariamos sobre temas diversos. Desvariamos sobre: - Cómo hacer arroz y su uso en ollas arroceras - Contrabando en nuestras respectivas ciudades - Cómo los locutores y la banda presumen sus bienes. - Juegos de la infancia, como los trompos y los tazos. - Remembranza de algunos programas anteriores - Estrenamos el Mercado Negro de Mal Vivir (el cuál nunca más volveríamos a usar xD) - Y otros temas menores más, como qué le pasó a S4E.

2do programa de Mal Vivir, programa donde hablamos de manga y demás, continuando con el tema de la semana pasada seguimos con las conquistas de Keima, esta vez solo las que han ocurrido dentro del manga (tristemente no fueron animadas y no hay probabilidad de que ocurra), con lo que pasamos desde la conquista de Tsukiyo Kujyo hasta la "conquista" de Akari Kurakawa

On today's show: Keima comes home (The World God Only Knows 264), the Sins struggle (Nanatsu no Taizai 71), the spotlight is misplaced (Kuroko no Basket 254), and absurdity proves greatness (Gintama 485).