Podcasts about MTOR

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from his discussions with Paul Turek and Paula Amato on male and female fertility; Rachel Rubin on menopause and hormone replacement therapy; Brian Kennedy on the biology of aging; Tanuj Nakra and Suzan Obagi on facial aging and skin rejuvenation; and BJ Miller and Bridget Sumser on lessons we can learn from the dying about how to live. Peter highlights the most important insights from each episode and any behavioral changes he's made for himself or his patients as a result of these fascinating discussions. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #358 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Summary of episode topics [1:15]; Episodes on fertility with Paul Turek and Paula Amato: insights on all things male and female fertility [4:45]; How men can optimize fertility [20:15]; How women can optimize fertility [26:00]; Rachel Rubin episode: insights on women's sexual health, menopause, and HRT [31:45]; How women can prepare for menopause: proactive care, evidence-based HRT, and more [41:45]; Brian Kennedy episode: understanding aging, role of inflammation and mTOR, and current limitations of aging clocks and biomarkers [46:30]; Advice from Brian Kennedy on testing longevity interventions [56:45]; Tanuj Nakra/Suzan Obagi episode: causes of facial aging and practical strategies for prevention and treatment [57:30]; Skincare: making sense of the wide range of skin resurfacing treatments [1:06:45]; How to create a realistic, sustainable skincare routine [1:12:30]; The dangers of following unqualified aesthetic advice online and the importance of getting professional medical guidance for cosmetic treatments [1:18:00]; BJ Miller/Bridget Sumser episode: lessons about living from the dying [1:21:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. This week on the Optimal Protein Podcast, I'm thrilled to be joined once again by Dr. Don Layman, one of the world's foremost experts in protein metabolism and amino acid science. In this first part of our two-part conversation, we take a deep dive into the true definition of protein quality, the flaws of current scoring systems, and the metabolic significance of leucine as a primary trigger for muscle protein synthesis. Dr. Layman also introduces the EAA-9 protein quality model, a new way of evaluating protein sources that takes into account the body's exact essential amino acid requirements—moving beyond methods like PDCAAS. Get 20% off on the Tone LUX Crystal Red Light Therapy Mask Ketogenicgirl.com with the code VANESSA We also discuss: Why protein quality should be defined by amino acid content, not nitrogen How leucine “shows up in nature” in exact ratios that muscle recognizes The four key signals muscle responds to: energy, leucine, insulin, and IGF-1 What activates and suppresses mTOR, and why AMPK shuts down MPS in low energy states How protein turnover drives up to 20% of your resting metabolic rate The concept of metabolic prioritization and what happens when your diet lacks adequate EAAs Why the term “protein requirement” is misleading—and why we actually have amino acid requirements Dr. Layman's response to the 100 g of protein study on protein distribution  A preview of what's really happening during fat loss, and how muscle preservation strategies can make or break long-term success This episode is a masterclass in muscle metabolism, protein science, and the tools you need to optimize your nutrition—especially for fat loss and body recomposition.

Healing isn't linear—and comfort is killing your progress. In this episode, we get real about why true metabolic flexibility (mTOR & AMPK), fasting vs. feasting, building muscle, electrolytes/hydration, and strategic protocols all demand seasons of intentional discomfort. We unpack the classic mistake: doing the right thing at the wrong time, wrong dose, or wrong order, and why your SIBO protocol, keto phase, or GI-MAP obsession didn't fix the terrain (liver, gallbladder, adrenals, stomach acid, biofilm, mold) that caused it. We also hit business, marriage, and mindset: new levels, new devils—and how to keep going when flares hit and faith is all you've got. *** Get Your Tickets Now: Use code REVIVAL for $100 discount ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FitMom | UNSTUCK: The Women's Health & Hormone Summit⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ *** Gut & Hormones all messed up? ⁠⁠⁠➡️ Take the quiz⁠⁠⁠ ***

Ein Antibiotikum, das eigentlich ganz andere Zwecke erfüllen sollte, sorgt bei Mäusen plötzlich für ein längeres Leben. Doch wie genau funktioniert das? Und: Was passiert, wenn Menschen sich diesen Stoff einfach selbst verabreichen? In dieser Folge geht es um „mTOR“, Krebs, und die vielleicht unterschätzteste Anti-Aging-Methode: Hunger. 00:38 Maus und Bakterium 03:26 Länger leben ≠ besser leben 05:13 Die Nachteile 09:59 Fasten statt Pharma?

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, and director of the Center for Healthy Longevity at the National University of Singapore. In this episode, Brian shares insights from ongoing human aging studies, including clinical trials of rapamycin and how dosing strategies, timing, and exercise may influence outcomes. He presents two key models of aging—one as a linear accumulation of biological decline and the other as an exponential rise in mortality risk—and explains why traditional models of aging fall short. He also explains why most current aging biomarkers lack clinical utility and describes how his team is working to develop a more actionable biological clock. Additional topics include the potential of compounds like alpha-ketoglutarate, urolithin A, and NAD boosters, along with how lifestyle interventions—such as VO2 max training, strength building, and the use of GLP-1 and SGLT2 drugs—may contribute to longer, healthier lives. We discuss: Brian's journey from the Buck Institute to Singapore, and the global evolution of aging research [2:45]; Rethinking the biology of aging: why models like the hallmarks of aging fall short [9:45]; How inflammation and mTOR signaling may play a central, causal role in aging [14:15]; The biological role of mTOR in aging, and the potential of rapamycin to slow aging and enhance immune resilience [17:30]; Aging as a linear decline in resilience overlaid with non-linear health fluctuations [22:30]; Speculating on the future of longevity: slowing biological aging through noise reduction and reprogramming [33:30]; Evaluating the role of the epigenome in aging, and the limits of methylation clocks [39:00]; Balancing the quest for immortality with the urgent need to improve late-life healthspan [43:00]; Comparing the big 4 chronic diseases: which are the most inevitable and modifiable? [47:15]; Exploring potential benefits of rapamycin: how Brian is testing this and other interventions in humans [51:45]; Testing alpha-ketoglutarate (AKG) for healthspan benefits in aging [1:01:45]; Exploring urolithin A's potential to enhance mitochondrial health, reduce frailty, and slow aging [1:05:30]; The potential of sublingual NAD for longevity, and the combination of NAD and AKG for metabolic and exercise enhancement [1:09:00]; Other interventions that may promote longevity: spermidine, 17

In this episode of The Progress Theory, host Dr Phil Price invites physiologist and researcher Dr Tom Jones from Northumbria University to discuss the intricacies of concurrent training. They delve into the concept of the interference effect—a phenomenon where endurance training can attenuate strength gains—and explore how various training modalities, intensities, and volumes can be manipulated to minimize this effect. Dr Jones shares insights from his varied research experience across different sports, including his work with the Newcastle United Academy and the Swedish Winter Sports Research Center. The conversation touches on the real-world application of concurrent training principles, crucial mistakes to avoid, and the latest scientific understanding of acute molecular signalling. Whether you're a coach, athlete, or fitness enthusiast, this episode offers valuable knowledge on optimising concurrent training for peak performance. Join us for a deep dive into the science of training with Dr Tom Jones on The Progress Theory!In this episode, we discuss:00:00 Introduction03:51 Sports Research Journey Across Nations08:46 "Concurrent Training Challenge in Football"10:49 Concurrent Training: "It Depends" Dilemma13:00 Aerobic Volume Limits Strength Gains16:12 Interference Effect in Concurrent Training19:56 mTOR and AMPK in Concurrent Training25:53 Diet Control and Cycling Research28:23 Aerobic Training's Interference on Strength33:04 Managing Fatigue in Training Sessions35:58 Understanding Technical Training Challenges38:51 Concurrent Training Strategy OverviewTakeaways

Ben Azadi joins Peak Human for a powerful, wide-ranging conversation on what it really takes to reclaim your metabolic health in a world of processed food, misinformation, and identity confusion. As the founder of Keto Kamp and bestselling author of Metabolic Freedom, Ben breaks down the biological and psychological barriers to health—from insulin resistance and the dangers of constant snacking to the mindset shifts required to become someone who actually lives in alignment with vitality and longevity. Host Brian Sanders and Ben dive deep into topics like fasting, hormone signaling, body recomposition, and the power of intention. This episode is as practical as it is inspiring, offering a blend of science, ancestral wisdom, and self-mastery.     Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 01:15 – Meet Ben Azadi: Real food, metabolic freedom, and seed oil awareness 03:10 – The Seed Oil Allergy Card: How to navigate restaurants safely 06:00 – Metabolic Flexibility 101: From sugar burner to fat burner 08:45 – Insulin Resistance is the Root: Why fasting insulin matters more than blood sugar 11:15 – Real vs. Processed Carbs: Potatoes vs. potato chips 13:00 – The Snacking Epidemic: 17 to 23 eating events a day 14:45 – Grazing = Aging: How frequent eating ages you faster 17:30 – mTOR vs. Autophagy: Bodybuilding, aging, and metabolic balance 20:00 – The Hayflick Limit: Cellular aging explained 21:45 – Longevity Mode vs. Growth Mode: Living in cycles 31:15 – Don't Be a Keto Zealot: Even Keto Kamp flexes 36:30 – Nutrient Density Always Wins: Why sugar fasting is not sustainable 40:15 – Metabolic Inflexibility on Both Ends: Fat burners can get stuck too 41:00 – The Diet Culture Trap: Why most diets fail 43:30 – The Subconscious Self-Image: Why your beliefs keep sabotaging you 47:45 – Sticky Note Protocol: The 30-day mental reprogramming 56:30 – Real Food & Movement = Real Results 57:30 – Third World vs. First World: Why simple food wins 58:30 – Final Takeaways: Real food, movement, and mindset still winno     REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

BUFFALO, NY — July 8, 2025 — As populations worldwide continue to age, understanding the mechanisms and manifestations of cognitive aging is increasingly urgent for science, medicine, and society. Age-related cognitive decline ranges from mild memory lapses to the onset of dementia, and is shaped by a complex interplay of molecular, cellular, systemic, and social determinants. In this special collection, Aging (Aging-US) seeks to bring together cutting-edge research that spans the cellular and molecular underpinnings of cognitive aging with insights into the psychosocial, behavioral, and environmental factors that modulate its course. By integrating basic biology with translational and societal dimensions, this collection aims to foster a holistic understanding of how and why cognitive function changes with age—and what can be done to preserve it. We welcome original research articles, reviews, and perspectives across model systems and human studies, particularly those that promote interdisciplinary insights and translational potential. POTENTIAL TOPICS Molecular and Cellular Mechanisms -Senescence, inflammation, and neurodegeneration in cognitive decline -Mitochondrial dysfunction and oxidative stress in aging neurons -Neurovascular aging and blood-brain barrier integrity -Single-cell and spatial transcriptomics of the aging brain -mTOR, autophagy, and proteostasis in age-related cognitive impairment -The role of glial cells (microglia, astrocytes) in brain aging Genetics and Biomarkers -Genetic risk factors and epigenetic modifications associated with cognitive aging -Biomarkers of cognitive resilience and vulnerability -Neuroimaging and fluid-based biomarkers in aging populations Interventions and Lifestyle Factors -Cognitive benefits of caloric restriction, exercise, or senolytic therapies -Preclinical and clinical trials targeting aging pathways to prevent cognitive decline -Impact of sleep, nutrition, and metabolic health on cognition in older adults -Use of cognitive strategies and compensatory techniques to maintain or enhance function in aging Environmental and Social Contexts -Impact of social isolation, education, and socioeconomic status on cognitive trajectories -Lifelong cognitive reserve and its determinants -Cross-cultural and demographic studies on aging and cognition -Digital health tools for monitoring or enhancing cognitive function in the elderly SUBMISSION DETAILS: -Submission Deadline: March 31, 2026 -Manuscript Format: Please follow the journal's submission guidelines -Peer Review: All submissions will undergo a rigorous peer-review process -Submission Link: https://aging.msubmit.net/cgi-bin/main.plex To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Arny Ferrando shares groundbreaking research on essential amino acids, muscle protein synthesis, and emerging cognitive benefits of targeted amino acid supplementation.• Essential amino acids (EAAs) produce greater anabolic response than whole proteins due to requiring no digestion and producing higher blood concentrations• Free-form EAAs need only 15 grams for maximal response compared to 40 grams of whey protein• Taking EAAs one hour before exercise provides optimal muscle protein synthesis due to increased blood flow during workouts• Physiological aging matters more than chronological age when determining nutritional interventions• New research shows EAAs may enhance cognitive function by modulating dopamine/serotonin balance• EAA supplementation helps mitigate muscle loss during bed rest or recovery from injury• The mTOR pathway's connection to cancer is often misinterpreted and shouldn't discourage proper protein intake• Testosterone replacement therapy should be based on symptoms rather than numbers alone• Higher protein turnover is energetically expensive, potentially helping with weight managementTry combining essential amino acids, protein, and creatine supplementation for optimal results, especially when recovering from injury or dealing with age-related muscle loss.

O Mauricio Medeiros é criador da técnica de execução MTOR e referência em musculação e saúde da mulher. No episódio de hoje do Kiwicast, ele conta como faturou R$ 8 milhões de reais ajudando a transformar a vida de profissionais de educação física com seu conhecimento.O que você vai aprender:- Como manter uma comunidade engajada- Estratégias que ele usou para se destacar no mercado- A criação do método MTOR- Diferenças entre treino para mulheres e homens- Estratégias de vendas do produto dele- Como as aulas gratuitas funcionam no funil de vendas - Pontos essenciais que um personal trainer precisa saberE muito mais!Quer aprender com quem vive isso na prática? Dá o play e deixe nos comentários qual foi o seu maior insight desse bate-papo.Nosso Instagram é @Kiwify

Try MacroFactor for free with code WITSANDWEIGHTS to see exactly how these walking breaks impact your daily calorie burn and support your muscle-building or fat loss goals or go to witsandweights.com/blog/macrofactor--Can you immediately increase muscle building by 47%?It's 3 PM on a Tuesday, and you've been glued to your desk since 8 AM. Your back is stiff, your energy is crashing, and you can feel that familiar tightness setting in from hours of sitting.But here's what you don't realize: that prolonged sitting isn't just making you uncomfortable. It's actively blocking your muscle protein synthesis, sabotaging your ability to build muscle from the food you eat.A groundbreaking 2022 study revealed a shocking truth: prolonged sitting can reduce your muscle protein synthesis by nearly 50%, effectively blocking your body's ability to build muscle from the protein you eat. This happens through multiple pathways we'll discuss, and there's a stupidly simple solution that can have the opposite effect and boost muscle building by 47%!Main Takeaways:Prolonged sitting creates "anabolic resistance" that can reduce muscle protein synthesis by up to 50%A simple walking hack can completely reverse this effect and boost muscle building by 47%The biological mechanisms: improved blood flow, enhanced amino acid delivery, reactivated mTOR signaling, and better insulin sensitivityCompound benefits beyond muscle building include stable energy, better blood sugar control, improved recoveryStudy Mentioned:Study by Moore et al. (2022) published in The Journal of PhysiologyTimestamps:0:01 - The hidden cost of prolonged sitting4:05 - Why sitting blocks muscle gains8:08 - How 2-minute breaks reverse the damage11:16 - Practical tips to implement TODAY14:15 - Compound effects beyond muscle buildingSupport the show

In this insightful episode, Dr. Jill Carnahan sits down with Dr. Amy Proal as they delve into the emerging connections between Bartonella infections and Long Covid, revealing new research that may reshape our understanding of chronic illness. Discover how the MTOR pathway plays a pivotal role in pathogen survival and mitochondrial health, and how drugs like rapamycin could be game-changers in managing these infections. We also explore Mast Cell Activation Syndrome (MCAS) and its links to unresolved infections, offering hope for treatment beyond medication. Key Discussions ①  Bartonella and Long Covid:

Seizures, sleepless nights, and mysterious white patches on his skin marked the beginning of Daniel's journey with Tuberous Sclerosis Complex (TSC). Diagnosed at age 6, Daniel faced a childhood filled with MRIs, EEGs, and specialist visits, often requiring cross-country travel for coordinated care. In this moving episode of On Rare, David Rintell, Head of Patient Advocacy at BridgeBio, and Mandy Rohrig, Senior Director of Patient Advocacy at BridgeBio Gene Therapy, speak with Daniel, a 31-year-old living in Seattle, about growing up with TSC, the emotional toll of visible symptoms, and the stigma he faced from peers. He reflects on the cognitive and mood impacts of TSC, including OCD and outbursts, and how he often kept to himself to feel more accepted. Today, Daniel is an active advocate in the TSC community, emphasizing the importance of connection, representation, and finding support among those with shared experiences. As he puts it, “You have to find your people.” Che-Wei Chang, Principal Scientist at BridgeBio, presents a medical overview of Tuberous Sclerosis Complex (TSC), a rare genetic disorder marked by seizures and benign tumors throughout the body. TSC results from a spontaneous mutation in a single copy of the TSC1 or TSC2 gene, which normally inhibit mTOR, an enzyme that regulates cell growth. Loss of this inhibition leads to mTOR hyperactivation, leading to abnormal cell proliferation and tumors in the brain, kidneys, skin, and other organs. Diagnosis typically involves identifying tubers in the brain along with tumors in other organs and is confirmed through genetic testing. Treatments include mTOR inhibitors, which are effective against many TSC-related tumors, and anti-seizure medications, although drug resistance is common.

️ Zona 2 y mitocondrias: LA VERDAD INCÓMODA que NO TE CUENTAN en los podcasts ¿De verdad entrenar en Zona 2 “crea mitocondrias”? ¿O estamos simplificando en exceso lo que pasa en tu cuerpo? En este episodio rompemos mitos y explicamos lo que realmente dice la fisiología del ejercicio: ✔️ Qué es la Zona 2 (y qué NO es) ✔️ Por qué hablar de ella sin entender el umbral aeróbico, VO₂ y lactato es un error ✔️ Qué papel juegan PGC-1α, AMPK, CaMK, mTOR y ROS ✔️ Cómo influyen la intensidad y el volumen en tus adaptaciones mitocondriales ✔️ Y por qué muchos divulgadores huyen del debate científico Si te interesa entrenar mejor, entender tu cuerpo y dejar de seguir modas mal explicadas, este vídeo es para ti. Ciencia real. Sin humo. Sin dogmas. Déjame en comentarios: ¿Qué otros mitos sobre el entrenamiento te gustaría que desmontáramos?

In this episode, Dr. Jockers and Dr. William Hsu dive into how nourished fasting can reduce insulin resistance, activate autophagy, and slow aging. They discuss how the fasting mimicking diet triggers cellular repair while still providing nourishment.   Learn how nutrient-sensing pathways like mTOR and IGF-1 influence metabolic health and why modern eating habits may accelerate aging. Dr. Hsu explains how short-term fasting can promote healing by tapping into the body's natural survival mechanisms.   Discover how to apply nourished fasting in your life with the ProLon protocol and why a few cycles a year can significantly improve your healthspan.   In This Episode: 00:00 Introduction to the Fast Mimicking Diet 02:49 Interview with Dr. William Hsu: Metabolic Health and Fasting 04:48 The Science Behind Fasting and Cellular Healing 06:49 The Evolutionary Perspective on Fasting 09:22 Understanding Nutrient Sensing Pathways 14:33 The Nobel Prize-Winning Research on Autophagy 17:44 The Concept of Fasting Mimicking Diet 21:25 Exploring the Benefits of Fasting Mimicking Diet 22:01 The Science Behind Fasting and Systemic Health 23:22 The Role of Lifestyle Medicine 24:16 Understanding Digestive Health and Stomach Acid 26:10 Hormetic Stress and Health Benefits 27:16 Clinical Research on Fasting Mimicking Diet 31:32 Practical Application of Fasting Mimicking Diet 32:43 Personalized Programs for Health Conditions 35:22 The Future of Lifestyle Medicine 40:54 Final Thoughts and Call to Action     Still cooking with seed oils? That could be fueling inflammation. I've switched to Paleovalley's 100% grass-fed beef tallow—it's rich in CLA, packed with flavor, and stable at high heat. It's one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order. Heartburn doesn't mean you have too much stomach acid—it usually means you don't have enough. That's why I recommend Just Thrive's Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you're supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.       "Autophagy is your body's self-cleaning cycle—and most people never turn it on." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio     Resources: Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS       Connect with Dr. William Hsu:  Website: https://l-nutra.com/portfolio/william-hsu-md/ Prolon 5 Day Fasting Mimicking Diet: https://prolonlife.com/       Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/     If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/  

In this episode, we delve into the fascinating world of C15, a newly recognized essential fatty acid, and its implications for longevity and health. Our guest, a leading expert in the field, Dr. Stephanie Venn-Watson shares her insights into the discovery and significance of C15, drawing connections between human health and findings from dolphin studies. Website - https://fatty15.com/JILLCARNAHAN  Key Discussions: ① The Discovery of C15:

Welcome back to the Longevity Podcast! I'm so excited for today's episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you've ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you. Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   What we discuss: Meet Chris Rhodes and his biomimetic research journey ... 00:05:18 Unlocking fasting benefits without prolonged fasting ... 00:09:10 Supplements vs. pharmaceuticals for longevity ... 00:10:53 Fasting protocols, timing, and metabolic switching ... 00:15:23 Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34 Ketones, brain energy, and cognitive adaptation ... 00:22:48 How fasting activates longevity and repair pathways ... 00:26:23 Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04 Mimio research: discovering and testing fasting metabolites ... 00:33:35 The four main fasting mimetic molecules explained ... 00:42:04 Practical benefits: who should use fasting mimetics & safety ... 00:59:00 Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37   Our Amazing Sponsors: Qualia NAD+ - This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. Check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. Bio-Shield by Young Goose - A broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.     More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

BUFFALO, NY — June 10, 2025 — The Ride for Roswell, one of the USA's largest cycling events supporting cancer research, returns to Buffalo on Saturday, June 28, 2025. Hosted annually by Roswell Park Comprehensive Cancer Center, this community-wide event brings together riders, volunteers, and supporters to raise funds for cancer research, celebrate survivors, and honor those lost to the disease. Among the returning participants is the Open Access Team, led by team captain Sergei Kurenov. This year, the team is once again proudly sponsored by Impact Journals, the publisher of open access journals Oncotarget, Aging, Genes & Cancer, and Oncoscience. “For the last 10 years, I have continuously participated in the Ride for Roswell in honor of those who have bravely fought cancer,” said Kurenov. “This journey is deeply personal for me. My father battled cancer, and some of my closest friends have fought through prostate and lung cancer with incredible strength.” This year, the Open Access Team rides in honor of Dr. Mikhail (Misha) Blagosklonny, a visionary scientist who dedicated his career to advancing cancer and aging research. As the founding Editor-in-Chief of Oncotarget, Aging, and Oncoscience, Dr. Blagosklonny was a pioneer of open-access publishing. His groundbreaking work on mTOR signaling and rapamycin transformed our understanding of cancer biology and healthy lifespan extension. The 2025 Ride for Roswell features nine route options, ranging from 4 to 100 miles, all beginning at the University at Buffalo North Campus. Riders from across the USA and beyond are invited to participate and make a meaningful impact in the fight against cancer. This ride is more than just a journey on two wheels—it's a commitment to building a future where no one has to fear a cancer diagnosis. There is still time to support the Open Open Access Team in the 2025 Ride for Roswell. Whether by donating, joining the team, or sharing their story, every action brings us closer to better treatments, deeper understanding, and, ultimately, a cure. Visit the Open Access Team page - https://give.roswellpark.org/site/TR/SpecialEvents/General?team_id=23320&pg=team&fr_id=2020 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — June 10, 2025 — The Ride for Roswell, one of the USA's largest cycling events supporting cancer research, returns to Buffalo on Saturday, June 28, 2025. Hosted annually by Roswell Park Comprehensive Cancer Center, this community-wide event brings together riders, volunteers, and supporters to raise funds for cancer research, celebrate survivors, and honor those lost to the disease. Among the returning participants is the Open Access Team, led by team captain Sergei Kurenov. This year, the team is once again proudly sponsored by Impact Journals, the publisher of open access journals Aging, Oncotarget, Genes & Cancer, and Oncoscience. “For the last 10 years, I have continuously participated in the Ride for Roswell in honor of those who have bravely fought cancer,” said Kurenov. “This journey is deeply personal for me. My father battled cancer, and some of my closest friends have fought through prostate and lung cancer with incredible strength.” This year, the Open Access Team rides in honor of Dr. Mikhail (Misha) Blagosklonny, a visionary scientist who dedicated his career to advancing cancer and aging research. As the founding Editor-in-Chief of Aging, Oncotarget and Oncoscience, Dr. Blagosklonny was a pioneer of open-access publishing. His groundbreaking work on mTOR signaling and rapamycin transformed our understanding of cancer biology and healthy lifespan extension. The 2025 Ride for Roswell features nine route options, ranging from 4 to 100 miles, all beginning at the University at Buffalo North Campus. Riders from across the USA and beyond are invited to participate and make a meaningful impact in the fight against cancer. This ride is more than just a journey on two wheels—it's a commitment to building a future where no one has to fear a cancer diagnosis. There is still time to support the Open Access Team in the 2025 Ride for Roswell. Whether by donating, joining the team, or sharing their story, every action brings us closer to better treatments, deeper understanding, and, ultimately, a cure. Visit the Open Access Team page - https://give.roswellpark.org/site/TR/SpecialEvents/General?team_id=23320&pg=team&fr_id=2020 To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Can we really reverse biological age?  In this groundbreaking episode, I sit down with Greg Macpherson, biotechnologist, pharmacist, and founder of SRW Laboratories, to explore the cutting-edge science behind reversing biological ageing — backed by real human clinical trial data. We discuss SRW's latest clinical study, which demonstrated measurable reductions in biological age markers through targeted supplementation. Greg unpacks how biological age is assessed using epigenetic markers like DNA methylation, and how SRW's formulations are designed to influence key aging pathways including: sirtuins, NAD+ production, AMPK, and mTOR modulation. What you'll learn from the episode:  What biological age really means  How SRW's trial measured age reversal using TruDiagnostic epigenetic clocks  Key molecules and compounds driving the effect  The importance of cellular senescence, mitochondrial function, and genomic stability  What's next in the field of longevity biotechnology Whether you're a health professional, biohacker, or longevity enthusiast, this episode is packed with science-forward insights and actionable takeaways. Shop SRW supplements here: SRW Supplement Range  Follow Greg Macpherson: Linkedin/Greg Nacpherson SRW  Explore epigenetic testing: Trudiagnostic - TruAge COMPLETE Greg Macpherson: Throughout my career, I have been driven by a desire to help people achieve their potential by overcoming health challenges. As a biotechnologist, futurist, author, and pharmacologist, I have pursued this goal by founding one of the first online pharmacies in New Zealand and creating the country's first Government licensed robotic dispensing facility. My current focus is on understanding cellular aging and developing new formulations to support healthy aging and improve human health. For the past 10 years, I have been researching cellular aging and consulting with global experts in the field. All of this research and experience has led me to establish SRW, an organization that aims to translate scientific advancements into practical solutions for everyday people to live longer, healthier lives.  

mTOR's a master determinant of lifespan and the engine of aging.

In this special episode of Skin Anarchy, host Dr. Ekta Yadav celebrates a milestone moment—her latest mini review, Inflammation and Aging: The Skin Inflammasome in the Context of Longevity Science, has been published in the Journal of Cellular Immunology. This episode offers listeners a deep but accessible dive into the mechanisms that link chronic inflammation, skin health, and the biology of aging.Dr. Yadav unpacks the concept of “inflammaging,” explaining how low-grade, persistent inflammation accelerates skin aging and predisposes us to a host of conditions—from acne and psoriasis to pigmentation disorders. Central to this is the NLRP3 inflammasome, a cellular sensor that responds to both internal stress and external insults. But the conversation doesn't stop at surface-level inflammation—it zooms out to show how NAD+ depletion, mTOR signaling, sirtuin activity, and cellular senescence all play a role in the skin's aging clock.Listeners will get a taste of the therapeutic landscape too—from the promise of repurposed drugs like metformin and rapamycin to the caution needed around immune modulation. Dr. Yadav also weaves in emerging research on gut-skin interactions and psychoneuroendocrine links, emphasizing the systemic nature of skin health in the context of longevity.If you're curious about the future of aging, biohacking, or the real science behind graceful skin longevity, this episode is a must-listen. Tune in to learn what's next in skin biology—and why inflammation is more than just skin deep.Read the full article HERE.To learn more about Dr. Ekta, visit her social media. Don't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions. Hosted on Acast. See acast.com/privacy for more information.

What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity. Learn more about Dr. Joan Mannick: https://www.linkedin.com/in/joan-mannick-8089a614/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

In this episode, we explore the impact of tech use and blue light on circadian biology, exploring how melanopsin and chromophores regulate physiology, mood, and cell functioning. The discussion highlights the leptin-melanocortin pathway, its role in placental physiology, and how ultra-weak biophotons from placental mitochondrial DNA influence fetal development, emphasizing the critical interplay of light and dark cycles in health.We further examine fetal brain development, focusing on mitochondria, neurogenesis, and the effects of UV light and nitric oxide on the thalamus and sensory integration. The episode connects BH4, tryptophan, and melanin deficits to Autism, discussing how environmental light and electromagnetic fields disrupt biological energy, contributing to neurodevelopmental problems and the Autistic phenotype.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:17 leptin-melanocortin pathway, biophotons, mitochondria, POMC, nitric oxide, BH4, fetal, placental physiology, fertility, ultra-weak biophotons, maternal blood, quantum biology, melanin, UV08:00 endocannabinoid, UV light, 380 nanometer, melanopsin, photo switch, brain development, leptin, mTOR, mitochondria, thalamus, sensory integration center, neurogenesis, fetal thalamus12:00 nitric oxide, autism, BH4, fetal ATP production, tryptophan, cellular redox, BPA, fluoride, deuterium absorption, electromagnetic fields, semiconduction, brain growth, biological energy16:03 Chroma Lights for Humans, use "autism" for 10% discount20:04 leptin-melanocortin pathway, leptin, adipose tissue, melanopsin, hypothalamus, POMC, placental physiology, ultra-weak biophotons, melanin, semiconductor, antioxidant, maternal physiology, brain volume24:23 biophotons, living cells, mitochondrial activity, cellular communication, electromagnetic waves, UV light wavelengths, energy, mitochondria, reactive oxygen species, TCA cycle, placental efficiency, thalamic timing28:29 mitochondrial DNA, retrograde signaling, gene expression, environmental cues, autism, heteroplasmy, biophoton coherence, calcium release, acetyl coenzyme A, fetal thalamus, neurogenesis, environmental light32:29 leptin-melanocortin pathway, neurodevelopmental problems, biophotons, somnathogenesis, circadian abnormalities, melanin, neural semiconduction, hyper excitability, hyper connectivity, salience network, attention, autistic phenotype36:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. This Friday's episode is a detailed solo recap of my interview with world-renowned protein researcher Dr. Stuart Phillips. In this science-packed conversation, we busted some of the most persistent and misleading myths in women's fitness, protein metabolism, and muscle growth. From fears around mTOR and kidney health to the truth about cycle syncing and menopause, this episode is all about clarity, confidence, and facts. If you've ever been confused by conflicting advice online — especially around how women “should” train or eat protein — this one's for you. TOP 12 MYTHS: The RDA for protein, high protein diets &  kidneys or bones, mTOR activation is bad for longevity, building muscle during your luteal phase, timing rules for protein and fasting, do women need less protein than men, muscle loss and menopause, lifting heavy vs moderate to get results and much more! Dr. Phillips brings research-backed clarity to all of these claims — including findings from his lab and collaborations with Dr. Lauren Colenso-Semple. Whether you're in your 30s, 40s, 50s, or beyond, this episode will empower you to focus on what actually works. Free high-protein keto guide: The Keto Reset eBook

In this episode of the Ageless Future, Regan Archibald dives deep into the world of peptides and muscle-building for longevity. He explores key muscle pathways like mTOR and AMPK, explains the importance of balancing growth and recovery, and highlights powerful peptides including CJC-1295, Ipamorelin, IGF-1 LR3, BPC-157, 5-Amino-1MQ, and SS-31. Regan also shares personal goals, advanced stacking strategies, and insights into how peptides like ACE-031 and MOTS-c help prevent sarcopenia and boost VO2 max. Whether you're optimizing for strength, recovery, or long-term vitality, this episode gives you the tools to strategically enhance muscle health at any age. www.agelessfuture.com

Send us a textEpisode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells' sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health.About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer Center at Weill Cornell Medicine. Nikos Koundouros, PhD is a postdoctoral fellow in Blenis' lab.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key  Points:mTOR pathway acts as a cellular “brain,” sensing nutrients like amino acids, glucose, and fats to regulate growth. Its dysregulation can drive cancer.High dietary omega-6 fatty acids, like linoleic acid found in seed oils, can fuel triple-negative breast cancer growth by activating mTOR.FABP5, a lipid chaperone protein, is overexpressed in triple-negative breast cancer, making these tumors more sensitive to omega-6 fats, suggesting its potential as a therapeutic target.Modern diets with high omega-6 to omega-3 ratios disrupt inflammation balance, unlike historical 1:1 ratios, potentially increasing cancer risk.Genetic variations and cancer subtypes highlight the need for tailored dietary recommendations, as blanket nutrition advice may not suit all patients.While omega-6 fats exacerbate existing triple-negative breast cancer, their role in initiating cancer remains unclear, requiring further study.High omega-6 intake may influence other cancers (e.g., prostate, colon) and chronic diseases like obesity, linked to FABP5 and inflammation.Related episode:M&M 200: Dietary Fats & Seed Oils in Inflammation, Colon Cancer & Chronic Disease | Tim Yeatman & GaneSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

How would you describe “longevity” to your patients? We've got an expert who can help. This week, we're just joined by Dr. Doris Day as she walks us through the concept of longevity. Listen in as she discusses diet, medications, psoriasis, eating schedules, the mTOR pathway, and why it makes sense to spoil your appetite. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com.   Doris Day, MD, is a board-certified dermatologist who specializes in cosmetic dermatology on the Upper East Side in New York City. She is a clinical professor of dermatology at the New York University Medical Center, where she received the Award for Dedication and Excellence in the Teaching of Dermatology. She has also been honored with the American Skin Association Award for Mentorship in Dermatology and the AAD Presidential Citation in recognition of her dedication and leadership in the field of aesthetic dermatology. Most recently, she was named the #3 Top Cosmetic Dermatologist in the U.S. by Newsweek. Dr. Day has received awards for her work in laser research and continues to actively participate in FDA clinical trials and publish in peer-reviewed medical journals. She regularly lectures both nationally and internationally to peers and the public. She is an active member of numerous professional organizations, including the American Society for Dermatologic Surgery and the American Academy of Dermatology, where she has served on the Board of Directors. She also holds a master's degree in medical journalism and has hosted The Dermatology Show on Doctor Radio (SiriusXM 110) for over 15 years. In addition to frequent appearances on national media and podcasts, she is the author of four books—her most recent titled Rebooting the Biome.

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

Les protéines sont des nutriments essentiels au bon fonctionnement de l'organisme. Elles interviennent dans la réparation des tissus, la digestion, le transport de l'oxygène via l'hémoglobine, et participent activement à la défense immunitaire. On les retrouve dans une grande variété d'aliments : produits laitiers, viandes, œufs, poissons, légumineuses, céréales… Pourtant, consommer trop de protéines, notamment via les régimes hyperprotéinés ou les produits enrichis (barres, poudres, yaourts), peut présenter des risques réels pour la santé.C'est ce qu'alerte l'Observatoire de la Prévention de l'Institut de cardiologie de Montréal. Dans un article de 2024, il met en garde contre le surdosage protéique, notamment issu des sources animales, qui pourrait augmenter le risque d'accidents cardiovasculaires (AVC). Cette alerte repose sur une étude américaine récente, menée à la fois sur des humains et des souris, qui s'est intéressée aux effets de la leucine, un acide aminé abondant dans la viande, les œufs et les produits laitiers.Les chercheurs ont observé que la leucine stimule une voie biologique appelée complexe mTOR, qui, en s'activant dans certaines cellules immunitaires (les macrophages), favorise la formation de plaques d'athérosclérose. Ces plaques peuvent obstruer les artères et augmenter significativement le risque d'AVC ou de crise cardiaque. Ainsi, consommer un repas très riche en protéines animales (plus de 25 g en une seule fois) serait un facteur aggravant, notamment chez les personnes à risque cardiovasculaire.En France, l'ANSES (Agence nationale de sécurité sanitaire de l'alimentation) recommande 0,8 g de protéines par kilo de poids corporel et par jour, soit environ 50 à 60 g pour une personne de 70 kg. Or, les données montrent que 85 % de la population dépasse cette dose, et près de 25 % consomment le double. Les chercheurs montréalais conseillent de ne pas excéder 1,4 à 1,5 g/kg/jour, soit 100 g maximum pour un adulte de 70 kg.Il est également essentiel de répartir les apports protéiques au cours de la journée : un excès ponctuel à un seul repas est plus nocif qu'une consommation modérée étalée. Par exemple, un petit-déjeuner avec un peu de fromage, un déjeuner avec une portion de viande, et un dîner végétarien à base de légumineuses permet un équilibre plus sain.En conclusion, si les protéines sont indispensables à la santé, leur excès, surtout d'origine animale, peut nuire aux artères et au cœur. Comme souvent en nutrition, l'équilibre reste la clé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Stephen and Richard delve into various aspects of nutrition, particularly focusing on the mTOR pathway, the transition from vegan to carnivore diets, and the implications of blood glucose levels on health. They discuss the myths surrounding post-workout nutrition, the importance of dietary transitions, and the impact of inflammation on health. The conversation also critiques popular diets, such as the sugar diet, and emphasizes the necessity of protein and fats in a balanced diet. In this conversation, Richard and Stephen discuss various aspects of the Skool community, including available courses, health concerns related to diet, and the importance of understanding the body's hormonal responses to dietary changes. They delve into specific health issues such as T4 to T3 conversion, the role of the pituitary gland, and the impact of dietary choices on cholesterol and calcium levels. The discussion also touches on the benefits of elimination diets and how they can alleviate certain health conditions, as well as tips for improving sleep during recovery from injuries.Chapters00:00 Introduction to the Conversation03:03 Understanding mTOR and Post-Workout Nutrition05:50 Transitioning from Vegan to Carnivore Diets08:50 Blood Glucose Levels and Weight Loss Challenges11:51 The Impact of Diet on Inflammation and Health14:47 The Importance of Transitioning to a Zero Carb Diet20:07 Addressing Migraines and Dietary Triggers24:57 Critique of the Sugar Diet and Bodybuilding Nutrition32:37 Introduction to Skool Community34:03 Courses and Resources Available35:28 Addressing Health Questions and Concerns39:40 Understanding T4 to T3 Conversion42:39 The Role of the Pituitary Gland44:10 Fruits and Vegetables in a Carnivore Diet48:12 Elimination Diets and TMJ Disorders51:16 Kefir and Dietary Adjustments54:41 Cholesterol Production and Dietary Impact58:09 Calcium Sources on a Carnivore Diet59:51 Sleep Issues and Recovery Tips

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human studies.0:00 Intro: Tackling the "Worst Longevity Idea Ever" Essay1:06 Who is Dr. Chris Masterjohn? Expertise Questioned3:20 Debunking Mouse Claims: Cataracts, Testicular Atrophy, Glucose Metabolism12:45 Fact Check: Rapamycin's Impact on Health Span (Benefits Ignored)17:02 mTOR, Fasting Cycles & Flawed Nutrient Signaling Arguments23:26 Debunking Claims: Heart Scarring, Fatty Liver, Shrinking Testicles27:28 Dose Comparisons, Marmoset Data & Keeping Up With Science31:27 Misleading Comparisons: Organ Transplant vs. Off-Label Use33:44 Correcting Claims on Testosterone, Wound Healing & Oral Inflammation36:55 The Real Rapamycin Data, Safety Profile & Final ThoughtsProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

TIME STAMPS:01:23  Yiann Stevens, from London, UK - IG @ yiannstevensc - How does one mature from viewing food as pleasure to viewing it as fuel?07:21 Battling DEPRESSION & ANXIETY by cleaning up your diet and the shikimate pathway!09:51 All about FRUIT and what compounds you need to watch out for in your grocery shopping if you're including carbohydrates in your diet.11:01 Chase, from Vancouver, WA, US - advice on LEAN BULKING on carnivore.17:34 The TRUTH about coffee! How to quit the most addictive substances on earth so that YOU run your life, and not food nor drugs.18:54 Jasmine Weise, from Australia - IG @ pom_ponyo “What's different in carnivore bodybuilding verses what traditional bodybuilding coaches teach? Should there be longer or shorter bulking periods and should they be as aggressive as most bodybuilders bulk and cut today?”25:11 Why CARBS do NOT increase muscle growth any faster for athletes already consuming adequate protein - Richard breaks down mTOR and INSULIN concerning their role in muscle protein synthesis.30:00 Chris Vilela, from Ontario, Canada - IG @ chris_vilela “Can strategically reintroducing specific types of carbs at certain times be used as a tool to support or improve body composition while following a carnivore diet?“31:00 L.I.S.S. #1 - “Carnivore Rick” from NY - IG @ carnivore.rick33:24 L.I.S.S. #2 - Thaddeus Hill - IG @ thaddeushil5638:02 BAD COACH CALLOUT - Intermittent fasting & keto are NOT fad diets!!!43:00 Lisa Moss, from Canada - IG - @ jazzylisaj - “Whats the most important thing for a menopausal woman when it comes to nutrition and fitness is more better or should I be doing less, for fear of stressing my body too much”48:14 https://www.skool.com/low-carb/about All of the information for COACH RICHARD'S SKOOL COMMUNITY!50:00 Stephanie Lewis - IG - @ stefi_liftz “How does one combat grief with nutrition? Has the carnivore diet helped you to cope with tragedies such as the loss of a loved one?”===========================================To custom order your own skull cable attachment, any color you like: https://supersetyourlife.com/products/rope-cable-attachment-extra-longKETOGENIC ATHLETE SUPPLEMENTS:Coach Colt's Supplement Store (US): https://supersetyourlife.com/collections/supplementsCoach Richard's Supplement Store (UK): https://theketopro.com/collections/keto-supplementsLink for KETO BRICKS: https://glnk.io/zvl/coltmiltonSave 10% on CARNIVORE BARS with code COLT10

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Join Steve and Nick on this week's podcast as they dive into the science of building muscle through smart nutrition! This episode explores the critical role of protein timing, pre- and post-workout meals, and how factors like cortisol, mTOR, and fasting impact muscle growth. From debunking myths about carbs and fats to sharing practical tips for men and women, this episode is packed with expert insights from Nick, a former body sculptor turned naturopath, and Steve's practical science-based wisdom! Whether you're a fitness newbie or a seasoned lifter, tune in to maximize your gains and avoid common pitfalls!   As always, this information is not designed to diagnose, treat, prevent, or cure any condition and is for information purposes only. Please discuss any information in this podcast with your healthcare professional before making any changes to your current lifestyle.  

Some Key Literature Review Studies from Year 14 This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward. 1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease.....Plus a to do list and recipe of the week. Dr. M

This episode is brought to you by Caldera Lab, Fatty 15 and LMNT. Today we explore the fascinating world of fasting with Renee Fitton, MS, RD, a distinguished longevity dietitian. Renee takes us through the science of fasting, emphasizing that you can fast with food, and discusses its surprising benefits for sexual health and even optimizing testosterone levels. She shares her expertise in longevity nutrition, highlighting how understanding biochemical pathways and innovations in healthcare can extend our health span. Listen in as we address common myths about fasting and introduce the fasting-mimicking diet, showcasing how fasting can regulate blood sugar and improve metabolism, while also enhancing brain health, particularly in the context of Alzheimer's. Follow Renee @fittonnutrition Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Benefits of Fasting for Health (06:46) Types of Fasting for Optimal Longevity (18:17) Fasting Myths and Truths (24:30) Caffeine, Plant Compounds, and Fasting (28:55) Reversing Type 2 Diabetes (40:56) Fasting Types and Safety Protocols (47:10) Prolonged Fasting Differences  (01:13:39) Biological Age, mTOR, and Transitioning Out of a Fast (01:24:54) Fasting Mimicking Diet Protocol (01:38:21) Embracing Progress, Not Perfection ----- Episode resources: Get 20% off your first order of premium men's skincare products with code EVERFORWARD at https://www.CalderaLab.com  Get an additional 15% off the C15:0 90-day starter kit with code EVERFORWARD at https://www.Fatty15.com/everforward Get a FREE sample variety pack of the best-tasting electrolytes with zero sugar at https://www.DrinkLMNT.com/everforward  Watch and subscribe on YouTube Fasting and religious purposes Fasting-mimicking and longevity

Dr. Ryan L. Cooley is a board-certified cardiac electrophysiologist with over 20 years of experience treating heart rhythm disorders. After adopting a low-carb lifestyle himself, he reversed his pre-diabetes—an experience that reshaped his approach to patient care. Now, he's a dedicated advocate for low-carb and ketogenic diets, often pairing them with intermittent fasting to help patients take control of their cardiometabolic health. Driven by both science and personal success, Dr. Cooley empowers others to make lasting, life-changing dietary choices. In this episode, Drs. Tro, Brian, and Ryan talk about… (00:00) Intro (02:39) Dr. Ryan's recent experience of being diagnosed with and fighting prostate cancer with natural metabolic therapies (11:34) Dr. Ryan's heart attack experience and what he learned from this experience (16:48) Gene mutations that make people more susceptible to obesity (23:19) Dr. Ryan's revelations about the medical system and nutrition following his heart attack (30:00) Vitamin C and cancer (31:50) Molecular Hydrogen Treatment (35:15) How exercise may have contributed to Dr. Ryan's cardiovascular troubles (37:05) LDL and cardiac events (39:29) Atrial fibrillation and insulin resistance (42:57) Treating atrial fibrillation (48:05) How Dr. Ryan's colleagues have responded to his holistic approach to chronic disease (50:10) Increased AF diagnoses in younger people in recent years (53:39) How Dr. Ryan changed his diet following his cancer diagnosis (57:43) Thermogenic stress (59:13) Stress and metabolic health (01:03:02) Hydrogenated water and why hydrogen is the best antioxidant (01:06:45) Protein and mTOR (01:08:40) All of the supplements Dr. Ryan takes for their cancer fighting benefits and/or their cardiovascular benefits (01:12:24) How Dr. Ryan's near death experiences have changed his outlook on life For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Dr. Ryan L. Cooley: Podcast: https://www.youtube.com/@TheMetabochondriacs Inter Mountain Health: https://doctors.intermountainhealth.org/provider/ryan-l-cooley/2556896 Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights for anyone serious about optimizing fitness, metabolism, and longevity. Learn more about Dr. Keith Baar: https://health.ucdavis.edu/physiology/faculty/baar.html

In this episode of the Heal Nourish Grow podcast, Dr. Chris Rhodes, a nutrition scientist, discusses his journey into the fields of longevity and fasting. He explains the significance of autophagy and shares his personal experiences with fasting. Dr. Rhodes also introduces Mimio, a product designed to mimic the benefits of fasting at the molecular level, and discusses the clinical studies that support its efficacy. The conversation delves into the science behind Mimeo's ingredients and their roles in promoting healthspan and longevity. Visit Mimio to learn more and get an awesome discount! Takeaways Fasting can activate longevity bio programs within our cells. Autophagy is a crucial process for cellular health and longevity. GLP-1 drugs like Ozembic may positively impact longevity pathways. Mimeo is designed to mimic the benefits of fasting without actual fasting. Clinical studies show Mimeo can improve metabolic health markers. The formulation of Mimeo includes powerful anti-aging molecules. Nicotinamide plays a key role in cellular energy and metabolism. Using Mimeo can enhance the benefits of shorter fasting periods. Maintaining a balance between mTOR activation and fasting pathways is essential for health. https://youtu.be/CidbXEJcj3k Episode transcript Cheryl McColgan (00:00.834)Hey everyone. Welcome to the Heal Nourish Grow Podcast. I don't even know the name of my own podcast. It's loving my words today. But anyway, I'm really excited about today's guest. I'm here with Dr. Chris Rhodes and he is a nutrition scientist. I'll let him better describe himself, but you will have heard his full bio, of course, before this, but I always like to start out, Dr. Rhodes, with just having you kind of share in your own words, what brought you into this space? What made you passionate about working with Mimeo Health and the technology there. Like what led you to this point? Dr. Chris Rhodes (00:32.962)Yeah, great question. Really happy to be here, Cheryl. Thanks for having me on. really got me interested into the longevity space, the healthy aging space, and eventually the fasting space was coming out of college. I got my BS in biochemistry from Leroy LaMaria Mount University, but like a lot of college kids didn't really know what I wanted to do there. So to try and figure that out, took an immunology fellowship at Stanford, just kind of pouring through all the research I could get my hands on going to all these seminars, and eventually came across the longevity research. And I thought that was so fascinating because it was this thing that used to be relegated to myth and legend, right? It was like Ponce de Leon and the Fountain of Youth. And now it's this very active, very rigorous area of scientific research with a ton of funding and a ton of companies and a ton of government and scientific attention on it. And it's one of those things that helps with everything, right? If you can solve aging, then you can pretty much also solve disease because by and large, most young folks don't get disease. really see that aging is something that's an underlying factor in every disease that happens. So if you can tackle these fundamental issues of aging at the cellular level and really slow that process down, then you can not only potentially enhance lifespan but also healthspan at the same time, which I think is what we're all really going for, living our lives as well as possible and as best health as possible for as long long as we can. When you're in the healthy aging and longevity space, eventually you come across fasting because fasting is one of the only ways that we know of to reliably extend lifespan and health span helps to treat, prevent, or delay most major diseases. And the reason why that was so fascinating to me is because it does all of that without actually adding anything into the system, right? So it's not this superfood or this wonder drug that's doing al...

Dr.Andy Franklyn-Miller is a world-leading specialist in sport and exercise medicine and the Chief Medical Officer at Nuritas. He is a highly accomplished physician with expertise in physiology, clinical design, and science communication, has a Ph.D. in Biomechanics, and served in the Royal Navy and Royal Marines for 16 years. Dr. Franklyn-Miller has extensive experience in working with high-profile sports teams and elite performers, has published more than 60 peer-reviewed papers, is an editor of the British Journal of Sports Medicine, and has authored a textbook and an IOC Handbook. With his expertise in machine learning, clinical trials, and end-user analysis, he oversees several departments at Nuritas, including software engineering, data curation, data science, proteomics, lab, and regulatory departments. Together, Dr. Franklyn-Miller and I explore the science behind PeptiStrong, a groundbreaking peptide developed by Nuritas, and discuss its clinical applications and research. If you have patients who are concerned with muscle retention as they age, who aren't recovering as quickly as they would like after exercise, or who are on GLP-1 medications and need to retain lean muscle mass, this conversation will be particularly engaging to you. Together, we cover the latest peptides data and studies and what it all means for healthcare practitioners.    I'm your host, Evelyne Lambrecht, thank you for designing a well world with us.   Episode Resources: Dr. Andy Franklyn-Miller - https://www.nuritas.com/team/dr-andy-franklyn-miller/ Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 02:28 Dr. Franklyn-Miller is feeling lit up by his current data analyses. 3:00 The ability to increase health in millions of people drew Dr. Franklyn-Miller to Nuritas. 4:02 What are peptides, and what are their function and benefits related to athletic performance? 7:33 Does PeptiStrong negatively impact those with a G6-PD deficiency? 8:52 Why don't PeptiStrong peptides break down as amino acids? 11:33 Three human clinical studies and their results and mechanisms of action. 14:09 The importance and controversy of the mTOR 1 and 2 pathways. 17:19 Key findings about muscular energy from the second human study. 20:58 Factors that effectively inhibit pathways that lead to sarcopenia. 22:22 The third study examines the impact of PeptiStrong on both men and women. 24:59 The impact of PeptiStrong on reducing inflammation and the effect on TNF-Alpha and on ATP production. 28:12 Prioritizing creatine, HMB, and leucine benefits with peptides in a synergistic way. 30:27 Creating optimal impact of PeptiStrong on various patient outcomes. 33:04 Studies that will address muscle mass at each stage of a woman's life. 38:52 Clinical guidelines for taking peptides to maximize effectiveness. 40:09 Observations from Dr. Franklyn-Miller's personal experience with taking PeptiStrong. 43:36 Optimal designs for future clinical trials and the role of peptides in shaping the future of healthcare. 55:35 Dr. Franklyn-Miller's personal favorite supplements, favorite health practices, and his evolved perspective on what food and medicine are really about.

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.Sponsors:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim (book a call today)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)*Links to everything discussed: https://tim.blog/2025/02/26/dr-keith-baar/Timestamps:[00:00:00] Start [00:07:12] How I discovered Keith's work through a tweet about tennis elbow and rock climbing.[00:07:54] Emil Abrahamsson's hangboard training protocol.[00:09:20] The fundamental principles of strength training and connective tissue adaptation.[00:10:36] mTOR complex 1 and its role in muscle growth.[00:12:06] Engineered ligaments and the discovery of minimal effective doses for tendon adaptation.[00:13:50] The refractory period between optimal tendon loading sessions.[00:16:42] Rapamycin's effects on muscle hypertrophy.[00:18:49] Protocols for tennis elbow rehabilitation.[00:20:28] Why isometrics work better than eccentrics for tendon healing.[00:22:14] Stress shielding and how load distribution affects tendon healing.[00:29:07] The misconception about eccentric loading for tendon injuries and why velocity matters.[00:29:58] Ideal duration for isometric holds (10-30 seconds) based on injury status.[00:33:50] My elbow issues and current rehab approach.[00:36:02] Overcoming vs. yielding isometrics and optimal loading strategies.[00:47:11] Dr. Barr's movement prescription for my tennis elbow.[00:52:18] Loading timing post-surgery and RICE protocol criticism.[00:56:58] Achilles tendon rehabilitation after surgery.[01:00:18] Critique of orthopedic suturing techniques and recommendation for resorbable sutures.[01:04:02] Multiple position isometrics for tennis elbow rehabilitation.[01:07:26] Collagen synthesis, supplementation, and vitamin C timing.[01:12:59] Critique of BPC-157 and other injectable peptides for tendon healing.[01:18:19] Evaluation of orthobiologics' (PRP, prolotherapy, stem cells) effectiveness.[01:21:37] JAK-STAT inhibitor drugs and their effects on tendon growth.[01:25:35] Drugs that increase risk of tendon ruptures (fluoroquinolones, AT-1 receptor drugs).[01:29:33] How estrogen affects tendon stiffness and injury risk in women.[01:32:48] Testosterone's opposite effects on tendon compared to estrogen.[01:35:31] Protein intake recommendations and timing.[01:40:11] Ketogenic diet effects on mitochondrial biogenesis and longevity.[01:41:57] Comparison of ketogenic diet, low protein diet, and rapamycin for longevity.[01:47:19] Inflammation's role in adaptation and when to reduce it.[01:51:17] Timing of ice baths relative to training for optimal recovery.[01:52:33] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

EP. 190: What if the key to not dying early—or at least living vibrantly—boils down to one thing? Metabolic health. In this episode, I sit down with Dr. Ben Bikman, one of the world's leading experts on insulin resistance & metabolic health. Dr. Bikman is a professor at Brigham Young University and the author of Why We Get Sick, a groundbreaking book that exposes how modern lifestyles are fueling diabetes, obesity, and heart disease. We break down: Why insulin resistance is the root cause of so many chronic conditions The real impact of GLP-1s on metabolism and fat cells The latest cutting-edge research on muscle and GLP1 from Dr. Bikman's lab at BYU What you can do today to take back control of your metabolic health How Insulin Resistance Fuels Chronic Disease—and What to Do About It The Surprising Role of Fat Cells in Metabolism and Hormone Balance Why ‘Eat Less, Move More' Fails Most People—and What Works Instead GLP-1s and Satiety: The Science Behind Appetite and Metabolic Control Cutting-Edge Metabolic Health Research from BYU That Could Change Everything Simple, Science-Backed Strategies to Boost Testosterone Naturally If you care about your hormones, metabolism, and long-term vitality, this episode is a must-listen. Join my FREE 21-Day Strength & Resilience Challenge to get started: www.drtyna.com/strengthandresilience Sponsored By: Timeline Timeline is offering 10% off your order of Mitopure. Go to timeline.com/drtyna.  Puori Go to Puori.com/drtyna and use code DRTYNA to get 20% off Purity Woods Go to puritywoods.com/DRTYNA or enter DRTYNA at checkout for 27% off Sundays Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. BIOptimizers For an exclusive offer go to bioptimizers.com/drtyna and use promo code DRTYNA On This Episode We Cover:  00:00:00 - Introduction 00:01:57 - Teaching at BYU 00:03:32 - Dr. Ben's books 00:05:42 - Defining insulin resistance 00:10:14 - Insulin resistance and chronic disease 00:17:50 - Viruses and fat cells 00:19:56 - Fast vs. slow insulin resistance 00:26:21 - Overfilled fat cells 00:28:24 - Issues with the “Eat less & exercise more” approach 00:31:27 - Genes and metabolic health 00:32:12 - Satiety & GLP-1 response 00:37:25 - Appetite control vs. suppression 00:39:22 - GLP-1 dosing 00:42:33 - Hormones and metabolism 00:48:13 - Estrogen replacement therapy and testing 00:51:57 - AMPK, mTOR, and supplementation 00:57:57 - Metformin study 00:59:46 - Easiest ways to increase testosterone Further Listening: 10 Health Trends We Are Ditching in 2025 | Solo Kick Off 2025 with Strength, Resilience & Purpose | Quick & Dirty The Surprising Health Connections Between You and Your Dog | Quick & Dirty Check Out Dr. Ben: Instagram Website Books Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

In this fascinating episode of Grow or Die, I sit down with Dr. Chris Rhodes, a PhD researcher specializing in fasting, metabolic health, and groundbreaking supplement science. We explore the untapped power of fasting and its profound effects on metabolic health, gut health, and cognitive performance. Dr. Rhodes shares key insights from his clinical research and personal experiences with multi-day fasting, breaking down the differences between intermittent fasting and extended fasting for true metabolic reset. We also introduce Mimeo, a revolutionary product designed to mimic the metabolic benefits of fasting without the need to abstain from food. This conversation offers a deep dive into fasting science, gut microbiome health, and how supplements like Mimeo can support optimal health.    Timestamps: - [00:00:00] - Justin introduces the episode, previews the topics, and welcomes Dr. Chris Rhodes. - [00:02:06] - Background on Dr. Rhodes' academic career and experience with fasting research. - [00:03:06] - Discussion on fasting for gut health, gut motility, and microbiome reset. - [00:05:18] - Dr. Rhodes explains why fasting for more than 24-36 hours is required for microbiome reset. - [00:08:09] - Dr. Rhodes shares his personal journey and what sparked his passion for fasting research. - [00:11:30] - Dr. Rhodes breaks down how fasting influences metabolic health, chronic inflammation, and energy prioritization. - [00:16:48] - ntroduction to PAOEA and spermine, two critical compounds related to longevity and health. - [00:19:28] - Discussion on mTOR's role in longevity, anti-aging, and muscle protein synthesis. - [00:22:32] - Justin and Dr. Rhodes discuss lean body mass, longevity, and maintaining health as one ages. - [00:29:22] - Identifying symptoms of chronic low energy, mental fatigue, and the role of fasting and supplements. - [00:34:32] - Dr. Rhodes shares insights on the pain relief benefits of palmitoylethanolamide (PEA) and its sourcing challenges. - [00:40:47] - The complexities of fasting for women, differences in hormonal response, and the challenges posed by diet culture. - [00:45:38] - Discussion on the reliability of nutritional science and how conflicting studies create confusion. - [00:53:09] - Dr. Rhodes reflects on his personal experience with a 60-hour fast and the empowerment it provided. - [01:01:13] - Justin wraps up the conversation and Dr. Rhodes shares how listeners can support Mimeo and follow him on social media.   Links & Resources: Follow Dr. Chris Rhodes On TikTok: @thatnutritiondr Check Out Mimio: https://mimiohealth.com/products/mimio-biomimetic-cell-care Follow Me On Instagram: @jmihaly_ Follow "Grow or Die" On Instagram: @growordiepodcast Work With Me: https://www.togethermorefit.com/founder Join Substack For More Exclusive Content: https://justinmihaly.substack.com/ Sign Up For The Together More Elite Mentorship: https://togethermorefit.com/elitepurchase

In this solosode, you’ll get to explore some of the most powerful tools and strategies for optimizing your body and mind. First, we’ll dive deep into the benefits of plant-based protein for building muscle. If you’re wondering whether plants can pack the same punch as animal-based sources, you’re in for some surprising insights. You’ll also get to explore minimalist training techniques—perfect for maintaining strength and muscle with less time and effort, so you can stay fit without spending hours in the gym. This episode is packed with actionable tips and insights designed to help you live a truly boundless life. Get ready to upgrade your health, performance, and mindset. Let’s dive in! 05:17 - Rebranding to The Boundless Life Podcast, reflections on a 17-year podcasting journey, and insights into a $25,000 blood filtration protocol in Tijuana.11:19 - The concept of solvitur ambulando ("solved by walking"), how walking improves learning, focus, neurogenesis, and boosts memory, mood, and cognitive performance.15:06 - Benefits of physical movement while learning, the Aristotelian peripatetic school approach, and using a manual treadmill for walking while working.27:13 - A study on maintaining 95% of fitness gains by training once every two weeks, combining strength and cardio in one session, and tips for efficient workouts.32:27 - Sauna use for muscle growth, recovery, and bone density via heat shock proteins, growth hormone, and mTOR activation, with evidence-based benefits from high-heat sessions.36:41 - Advantages of "weekend warrior" workouts, plant-based vs. animal-based proteins for athletic performance, and the role of leucine in boosting muscle protein synthesis on plant-based diets.44:06 - Effective melatonin use for sleep and jet lag, issues with over-the-counter dosing inaccuracies, and selecting reliable supplement brands. Full show notes: BenGreenfieldLife.com/482 Episode Sponsors: Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go to Joovv.com/ben and apply code BEN. ZBiotics Pre-Alcohol Probiotic: Order with the confidence of a 100% money-back guarantee and 15% off your first order at zbiotics.com/BEN15 when you use code BEN15. Beekeeper's Naturals: Beekeeper’s Naturals is offering you an exclusive offer—go to beekeepersnaturals.com/BEN or enter code BEN to get 20% off your order. C60 Power: Visit shopc60.com/ben-greenfield and use coupon code GREENFIELD15 for 15% off your first order—start taking back control over your cellular health today! LVLUP Health: Head over to lvluphealth.com/BGL for a special discount on their game-changing range of products.See omnystudio.com/listener for privacy information.

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit? Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity. They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter. What you'll learn: • Why metabolic flexibility matters more than strict diet rules • The science behind long-term ketosis and insulin's broader role in health • How common “health foods” could be doing more harm than good • The importance of nutrient-dense animal-based foods for gut and immune health • How to achieve optimal balance between fat types, mTOR, and longevity markers Resources: 2025 Biohacking Conference – https://biohackingconference.com/2025 Shop Paul Saladino's Products – https://heartandsoil.co Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/ Paul Saladino's Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow Danger Coffee – https://dangercoffee.com Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ Dave Asprey's Website – https://daveasprey.com Dave Asprey's Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey's Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave. Timestamps: • 00:00 Intro • 00:40 Paul Saladino's Evolution in Diet • 01:21 Challenges of a Strict Carnivore Diet • 03:36 Reintroducing Carbohydrates • 05:32 Debunking Common Diet Myths • 13:49 The Problem with Calorie Restriction • 18:30 The Importance of Food Quality • 24:08 The Veganism Debate • 34:15 The Benefits of Organ Meats • 37:27 Foot Surgery and Bone Density • 39:23 Mineral Deficiency and Plant-Based Diets • 40:00 The Truth About Seed Oils • 41:10 Historical Studies on Seed Oils • 47:26 Mechanisms and Effects of Seed Oils • 52:33 Nicotine and Neuroprotection • 54:12 Oleic Acid and Longevity • 01:01:44 The Benefits of Animal Fats• 01:02:32 Odd Chain Fatty Acids and Health • 01:11:07 Cheese and Dairy Considerations • 01:13:11 The Impact of Cheese on Health • 01:14:03 Protein Intake and Longevity • 01:14:54 Understanding mTOR and Its Effects • 01:17:35 Ideal Body Fat and Metabolic Health • 01:24:38 The Role of Omega Fatty Acids • 01:32:46 ApoB, Insulin Sensitivity, and Longevity • 01:43:09 Final Thoughts and Product Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.