Podcasts about MTOR

mTOR's a master determinant of lifespan and the engine of aging.

In this special episode of Skin Anarchy, host Dr. Ekta Yadav celebrates a milestone moment—her latest mini review, Inflammation and Aging: The Skin Inflammasome in the Context of Longevity Science, has been published in the Journal of Cellular Immunology. This episode offers listeners a deep but accessible dive into the mechanisms that link chronic inflammation, skin health, and the biology of aging.Dr. Yadav unpacks the concept of “inflammaging,” explaining how low-grade, persistent inflammation accelerates skin aging and predisposes us to a host of conditions—from acne and psoriasis to pigmentation disorders. Central to this is the NLRP3 inflammasome, a cellular sensor that responds to both internal stress and external insults. But the conversation doesn't stop at surface-level inflammation—it zooms out to show how NAD+ depletion, mTOR signaling, sirtuin activity, and cellular senescence all play a role in the skin's aging clock.Listeners will get a taste of the therapeutic landscape too—from the promise of repurposed drugs like metformin and rapamycin to the caution needed around immune modulation. Dr. Yadav also weaves in emerging research on gut-skin interactions and psychoneuroendocrine links, emphasizing the systemic nature of skin health in the context of longevity.If you're curious about the future of aging, biohacking, or the real science behind graceful skin longevity, this episode is a must-listen. Tune in to learn what's next in skin biology—and why inflammation is more than just skin deep.Read the full article HERE.To learn more about Dr. Ekta, visit her social media. Don't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions. Hosted on Acast. See acast.com/privacy for more information.

What if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity. Learn more about Dr. Joan Mannick: https://www.linkedin.com/in/joan-mannick-8089a614/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. This Friday's episode is a detailed solo recap of my interview with world-renowned protein researcher Dr. Stuart Phillips. In this science-packed conversation, we busted some of the most persistent and misleading myths in women's fitness, protein metabolism, and muscle growth. From fears around mTOR and kidney health to the truth about cycle syncing and menopause, this episode is all about clarity, confidence, and facts. If you've ever been confused by conflicting advice online — especially around how women “should” train or eat protein — this one's for you. TOP 12 MYTHS: The RDA for protein, high protein diets &  kidneys or bones, mTOR activation is bad for longevity, building muscle during your luteal phase, timing rules for protein and fasting, do women need less protein than men, muscle loss and menopause, lifting heavy vs moderate to get results and much more! Dr. Phillips brings research-backed clarity to all of these claims — including findings from his lab and collaborations with Dr. Lauren Colenso-Semple. Whether you're in your 30s, 40s, 50s, or beyond, this episode will empower you to focus on what actually works. Free high-protein keto guide: The Keto Reset eBook

In this episode of the Ageless Future, Regan Archibald dives deep into the world of peptides and muscle-building for longevity. He explores key muscle pathways like mTOR and AMPK, explains the importance of balancing growth and recovery, and highlights powerful peptides including CJC-1295, Ipamorelin, IGF-1 LR3, BPC-157, 5-Amino-1MQ, and SS-31. Regan also shares personal goals, advanced stacking strategies, and insights into how peptides like ACE-031 and MOTS-c help prevent sarcopenia and boost VO2 max. Whether you're optimizing for strength, recovery, or long-term vitality, this episode gives you the tools to strategically enhance muscle health at any age. www.agelessfuture.com

Send us a textEpisode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells' sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health.About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer Center at Weill Cornell Medicine. Nikos Koundouros, PhD is a postdoctoral fellow in Blenis' lab.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key  Points:mTOR pathway acts as a cellular “brain,” sensing nutrients like amino acids, glucose, and fats to regulate growth. Its dysregulation can drive cancer.High dietary omega-6 fatty acids, like linoleic acid found in seed oils, can fuel triple-negative breast cancer growth by activating mTOR.FABP5, a lipid chaperone protein, is overexpressed in triple-negative breast cancer, making these tumors more sensitive to omega-6 fats, suggesting its potential as a therapeutic target.Modern diets with high omega-6 to omega-3 ratios disrupt inflammation balance, unlike historical 1:1 ratios, potentially increasing cancer risk.Genetic variations and cancer subtypes highlight the need for tailored dietary recommendations, as blanket nutrition advice may not suit all patients.While omega-6 fats exacerbate existing triple-negative breast cancer, their role in initiating cancer remains unclear, requiring further study.High omega-6 intake may influence other cancers (e.g., prostate, colon) and chronic diseases like obesity, linked to FABP5 and inflammation.Related episode:M&M 200: Dietary Fats & Seed Oils in Inflammation, Colon Cancer & Chronic Disease | Tim Yeatman & GaneSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts

How would you describe “longevity” to your patients? We've got an expert who can help. This week, we're just joined by Dr. Doris Day as she walks us through the concept of longevity. Listen in as she discusses diet, medications, psoriasis, eating schedules, the mTOR pathway, and why it makes sense to spoil your appetite. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com.   Doris Day, MD, is a board-certified dermatologist who specializes in cosmetic dermatology on the Upper East Side in New York City. She is a clinical professor of dermatology at the New York University Medical Center, where she received the Award for Dedication and Excellence in the Teaching of Dermatology. She has also been honored with the American Skin Association Award for Mentorship in Dermatology and the AAD Presidential Citation in recognition of her dedication and leadership in the field of aesthetic dermatology. Most recently, she was named the #3 Top Cosmetic Dermatologist in the U.S. by Newsweek. Dr. Day has received awards for her work in laser research and continues to actively participate in FDA clinical trials and publish in peer-reviewed medical journals. She regularly lectures both nationally and internationally to peers and the public. She is an active member of numerous professional organizations, including the American Society for Dermatologic Surgery and the American Academy of Dermatology, where she has served on the Board of Directors. She also holds a master's degree in medical journalism and has hosted The Dermatology Show on Doctor Radio (SiriusXM 110) for over 15 years. In addition to frequent appearances on national media and podcasts, she is the author of four books—her most recent titled Rebooting the Biome.

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

Les protéines sont des nutriments essentiels au bon fonctionnement de l'organisme. Elles interviennent dans la réparation des tissus, la digestion, le transport de l'oxygène via l'hémoglobine, et participent activement à la défense immunitaire. On les retrouve dans une grande variété d'aliments : produits laitiers, viandes, œufs, poissons, légumineuses, céréales… Pourtant, consommer trop de protéines, notamment via les régimes hyperprotéinés ou les produits enrichis (barres, poudres, yaourts), peut présenter des risques réels pour la santé.C'est ce qu'alerte l'Observatoire de la Prévention de l'Institut de cardiologie de Montréal. Dans un article de 2024, il met en garde contre le surdosage protéique, notamment issu des sources animales, qui pourrait augmenter le risque d'accidents cardiovasculaires (AVC). Cette alerte repose sur une étude américaine récente, menée à la fois sur des humains et des souris, qui s'est intéressée aux effets de la leucine, un acide aminé abondant dans la viande, les œufs et les produits laitiers.Les chercheurs ont observé que la leucine stimule une voie biologique appelée complexe mTOR, qui, en s'activant dans certaines cellules immunitaires (les macrophages), favorise la formation de plaques d'athérosclérose. Ces plaques peuvent obstruer les artères et augmenter significativement le risque d'AVC ou de crise cardiaque. Ainsi, consommer un repas très riche en protéines animales (plus de 25 g en une seule fois) serait un facteur aggravant, notamment chez les personnes à risque cardiovasculaire.En France, l'ANSES (Agence nationale de sécurité sanitaire de l'alimentation) recommande 0,8 g de protéines par kilo de poids corporel et par jour, soit environ 50 à 60 g pour une personne de 70 kg. Or, les données montrent que 85 % de la population dépasse cette dose, et près de 25 % consomment le double. Les chercheurs montréalais conseillent de ne pas excéder 1,4 à 1,5 g/kg/jour, soit 100 g maximum pour un adulte de 70 kg.Il est également essentiel de répartir les apports protéiques au cours de la journée : un excès ponctuel à un seul repas est plus nocif qu'une consommation modérée étalée. Par exemple, un petit-déjeuner avec un peu de fromage, un déjeuner avec une portion de viande, et un dîner végétarien à base de légumineuses permet un équilibre plus sain.En conclusion, si les protéines sont indispensables à la santé, leur excès, surtout d'origine animale, peut nuire aux artères et au cœur. Comme souvent en nutrition, l'équilibre reste la clé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Stephen and Richard delve into various aspects of nutrition, particularly focusing on the mTOR pathway, the transition from vegan to carnivore diets, and the implications of blood glucose levels on health. They discuss the myths surrounding post-workout nutrition, the importance of dietary transitions, and the impact of inflammation on health. The conversation also critiques popular diets, such as the sugar diet, and emphasizes the necessity of protein and fats in a balanced diet. In this conversation, Richard and Stephen discuss various aspects of the Skool community, including available courses, health concerns related to diet, and the importance of understanding the body's hormonal responses to dietary changes. They delve into specific health issues such as T4 to T3 conversion, the role of the pituitary gland, and the impact of dietary choices on cholesterol and calcium levels. The discussion also touches on the benefits of elimination diets and how they can alleviate certain health conditions, as well as tips for improving sleep during recovery from injuries.Chapters00:00 Introduction to the Conversation03:03 Understanding mTOR and Post-Workout Nutrition05:50 Transitioning from Vegan to Carnivore Diets08:50 Blood Glucose Levels and Weight Loss Challenges11:51 The Impact of Diet on Inflammation and Health14:47 The Importance of Transitioning to a Zero Carb Diet20:07 Addressing Migraines and Dietary Triggers24:57 Critique of the Sugar Diet and Bodybuilding Nutrition32:37 Introduction to Skool Community34:03 Courses and Resources Available35:28 Addressing Health Questions and Concerns39:40 Understanding T4 to T3 Conversion42:39 The Role of the Pituitary Gland44:10 Fruits and Vegetables in a Carnivore Diet48:12 Elimination Diets and TMJ Disorders51:16 Kefir and Dietary Adjustments54:41 Cholesterol Production and Dietary Impact58:09 Calcium Sources on a Carnivore Diet59:51 Sleep Issues and Recovery Tips

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human studies.0:00 Intro: Tackling the "Worst Longevity Idea Ever" Essay1:06 Who is Dr. Chris Masterjohn? Expertise Questioned3:20 Debunking Mouse Claims: Cataracts, Testicular Atrophy, Glucose Metabolism12:45 Fact Check: Rapamycin's Impact on Health Span (Benefits Ignored)17:02 mTOR, Fasting Cycles & Flawed Nutrient Signaling Arguments23:26 Debunking Claims: Heart Scarring, Fatty Liver, Shrinking Testicles27:28 Dose Comparisons, Marmoset Data & Keeping Up With Science31:27 Misleading Comparisons: Organ Transplant vs. Off-Label Use33:44 Correcting Claims on Testosterone, Wound Healing & Oral Inflammation36:55 The Real Rapamycin Data, Safety Profile & Final ThoughtsProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

TIME STAMPS:01:23  Yiann Stevens, from London, UK - IG @ yiannstevensc - How does one mature from viewing food as pleasure to viewing it as fuel?07:21 Battling DEPRESSION & ANXIETY by cleaning up your diet and the shikimate pathway!09:51 All about FRUIT and what compounds you need to watch out for in your grocery shopping if you're including carbohydrates in your diet.11:01 Chase, from Vancouver, WA, US - advice on LEAN BULKING on carnivore.17:34 The TRUTH about coffee! How to quit the most addictive substances on earth so that YOU run your life, and not food nor drugs.18:54 Jasmine Weise, from Australia - IG @ pom_ponyo “What's different in carnivore bodybuilding verses what traditional bodybuilding coaches teach? Should there be longer or shorter bulking periods and should they be as aggressive as most bodybuilders bulk and cut today?”25:11 Why CARBS do NOT increase muscle growth any faster for athletes already consuming adequate protein - Richard breaks down mTOR and INSULIN concerning their role in muscle protein synthesis.30:00 Chris Vilela, from Ontario, Canada - IG @ chris_vilela “Can strategically reintroducing specific types of carbs at certain times be used as a tool to support or improve body composition while following a carnivore diet?“31:00 L.I.S.S. #1 - “Carnivore Rick” from NY - IG @ carnivore.rick33:24 L.I.S.S. #2 - Thaddeus Hill - IG @ thaddeushil5638:02 BAD COACH CALLOUT - Intermittent fasting & keto are NOT fad diets!!!43:00 Lisa Moss, from Canada - IG - @ jazzylisaj - “Whats the most important thing for a menopausal woman when it comes to nutrition and fitness is more better or should I be doing less, for fear of stressing my body too much”48:14 https://www.skool.com/low-carb/about All of the information for COACH RICHARD'S SKOOL COMMUNITY!50:00 Stephanie Lewis - IG - @ stefi_liftz “How does one combat grief with nutrition? Has the carnivore diet helped you to cope with tragedies such as the loss of a loved one?”===========================================To custom order your own skull cable attachment, any color you like: https://supersetyourlife.com/products/rope-cable-attachment-extra-longKETOGENIC ATHLETE SUPPLEMENTS:Coach Colt's Supplement Store (US): https://supersetyourlife.com/collections/supplementsCoach Richard's Supplement Store (UK): https://theketopro.com/collections/keto-supplementsLink for KETO BRICKS: https://glnk.io/zvl/coltmiltonSave 10% on CARNIVORE BARS with code COLT10

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Exklusives Coaching und Webinare mit Dr. Bredehorst: https://cellsciencepodcast.de/Dr. Kay Bredehorst über Bryan Johnson und David Sinclair und was wirklich dran ist.mTOR, Sirt Gene und Longevity sindBioverfügbares Kurkuma: https://mitocare.de/products/lipo-curcumin-boosterCode: V60014Achtung: Iss Getreide, Hülsenfrüchte oder Mais niemals roh. Die besten Ernährungstipps für einen gesunden Darm und warum Kurkuma zu 99% nicht aufgenommen wird, erfährst du in diesem Video.Inhaltsverzeichnis:00:00 Intro04:30 Vorteile pflanzlicher Ernährung07:20 SIRT - Zellen die ständig im Betrieb sind, gehen kaputt10:30 Fasten13:00 NMN ist Novel Food (In Deutschland verboten!!)15:00 NAD wird hier genutzt. SIRT arbeitet danach schneller19:00 mTOR POWER (Zucker und Protein)22:30 Gesunde Lebensmittel und sekundäre Pflanzenstoffe29:30 AMPK Gen und Bewegung34:30 RegenerationsphasenMehr Infos zu ….–Mehr von Mr. Broccoli:Homepage: https://www.vegan-athletes.comAbonniere meinen YouTube Kanal: https://www.youtube.com/@mrbroccoliInstagram: https://www.instagram.com/mrbroccoli.official/Telegram (für besonders brisante Themen): https://t.me/mrbroccoli_veganNewsletter: https://www.vegan-athletes.com/newsletter-vegan-athletes/➤➤➤ Meine 10 Favoriten für mehr Gesundheit: https://www.vegan-athletes.com/empfehlungen/

Join Steve and Nick on this week's podcast as they dive into the science of building muscle through smart nutrition! This episode explores the critical role of protein timing, pre- and post-workout meals, and how factors like cortisol, mTOR, and fasting impact muscle growth. From debunking myths about carbs and fats to sharing practical tips for men and women, this episode is packed with expert insights from Nick, a former body sculptor turned naturopath, and Steve's practical science-based wisdom! Whether you're a fitness newbie or a seasoned lifter, tune in to maximize your gains and avoid common pitfalls!   As always, this information is not designed to diagnose, treat, prevent, or cure any condition and is for information purposes only. Please discuss any information in this podcast with your healthcare professional before making any changes to your current lifestyle.  

Some Key Literature Review Studies from Year 14 This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward. 1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease.....Plus a to do list and recipe of the week. Dr. M

BUFFALO, NY — April 3, 2025 — Aging (Aging-US) is pleased to announce a special Call for Papers for a commemorative collection honoring the legacy of Dr. Mikhail (Misha) Blagosklonny, the founding editor of the journal and a pioneer in aging biology. His groundbreaking work shaped fundamental concepts in the field, particularly regarding the role of mTOR in aging and cancer, the use of rapamycin, bypassing senescence during the process of transformation, personalized medicine, and theories on why we age. This special collection will explore key themes central to Dr. Blagosklonny's scientific contributions, with a focus on mechanistic insights, translational approaches, and theoretical perspectives. We invite original research, reviews, and perspective articles covering topics such as: The role of mTOR in aging and age-related diseases Rapamycin and other pharmacological strategies to extend lifespan Senescence bypass and its implications for cancer and regenerative medicine Personalized medicine approaches in aging and longevity research Theoretical models and evolutionary perspectives on aging The special issue will be guest-edited by leading scientist in the field, David Gems, who will oversee the selection of high-quality contributions that reflect the depth and impact of Dr. Blagosklonny's work. We encourage researchers working on these topics to submit their manuscripts and contribute to this tribute to one of the most influential figures in aging research. SUBMISSION DETAILS: Submission Deadline: December 1, 2025 Manuscript Format: Please follow the journal's submission guidelines Peer Review: All submissions will undergo a rigorous peer-review process Submission Link: https://aging.msubmit.net/cgi-bin/main.plex We look forward to your contributions to this special issue and to honoring Dr. Blagosklonny's enduring impact on the field of aging research. To learn more about Aging (Aging-US), please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

This episode is brought to you by Caldera Lab, Fatty 15 and LMNT. Today we explore the fascinating world of fasting with Renee Fitton, MS, RD, a distinguished longevity dietitian. Renee takes us through the science of fasting, emphasizing that you can fast with food, and discusses its surprising benefits for sexual health and even optimizing testosterone levels. She shares her expertise in longevity nutrition, highlighting how understanding biochemical pathways and innovations in healthcare can extend our health span. Listen in as we address common myths about fasting and introduce the fasting-mimicking diet, showcasing how fasting can regulate blood sugar and improve metabolism, while also enhancing brain health, particularly in the context of Alzheimer's. Follow Renee @fittonnutrition Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Benefits of Fasting for Health (06:46) Types of Fasting for Optimal Longevity (18:17) Fasting Myths and Truths (24:30) Caffeine, Plant Compounds, and Fasting (28:55) Reversing Type 2 Diabetes (40:56) Fasting Types and Safety Protocols (47:10) Prolonged Fasting Differences  (01:13:39) Biological Age, mTOR, and Transitioning Out of a Fast (01:24:54) Fasting Mimicking Diet Protocol (01:38:21) Embracing Progress, Not Perfection ----- Episode resources: Get 20% off your first order of premium men's skincare products with code EVERFORWARD at https://www.CalderaLab.com  Get an additional 15% off the C15:0 90-day starter kit with code EVERFORWARD at https://www.Fatty15.com/everforward Get a FREE sample variety pack of the best-tasting electrolytes with zero sugar at https://www.DrinkLMNT.com/everforward  Watch and subscribe on YouTube Fasting and religious purposes Fasting-mimicking and longevity

Dr. Ryan L. Cooley is a board-certified cardiac electrophysiologist with over 20 years of experience treating heart rhythm disorders. After adopting a low-carb lifestyle himself, he reversed his pre-diabetes—an experience that reshaped his approach to patient care. Now, he's a dedicated advocate for low-carb and ketogenic diets, often pairing them with intermittent fasting to help patients take control of their cardiometabolic health. Driven by both science and personal success, Dr. Cooley empowers others to make lasting, life-changing dietary choices. In this episode, Drs. Tro, Brian, and Ryan talk about… (00:00) Intro (02:39) Dr. Ryan's recent experience of being diagnosed with and fighting prostate cancer with natural metabolic therapies (11:34) Dr. Ryan's heart attack experience and what he learned from this experience (16:48) Gene mutations that make people more susceptible to obesity (23:19) Dr. Ryan's revelations about the medical system and nutrition following his heart attack (30:00) Vitamin C and cancer (31:50) Molecular Hydrogen Treatment (35:15) How exercise may have contributed to Dr. Ryan's cardiovascular troubles (37:05) LDL and cardiac events (39:29) Atrial fibrillation and insulin resistance (42:57) Treating atrial fibrillation (48:05) How Dr. Ryan's colleagues have responded to his holistic approach to chronic disease (50:10) Increased AF diagnoses in younger people in recent years (53:39) How Dr. Ryan changed his diet following his cancer diagnosis (57:43) Thermogenic stress (59:13) Stress and metabolic health (01:03:02) Hydrogenated water and why hydrogen is the best antioxidant (01:06:45) Protein and mTOR (01:08:40) All of the supplements Dr. Ryan takes for their cancer fighting benefits and/or their cardiovascular benefits (01:12:24) How Dr. Ryan's near death experiences have changed his outlook on life For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Dr. Ryan L. Cooley: Podcast: https://www.youtube.com/@TheMetabochondriacs Inter Mountain Health: https://doctors.intermountainhealth.org/provider/ryan-l-cooley/2556896 Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Can muscle growth and longevity coexist? Dr. Keith Baar breaks down the science of exercise, diet, and aging—focusing on the mTOR pathway, muscle hypertrophy, and how resistance vs. endurance training impacts long-term health. Learn how personalized health strategies, isometric exercises, and ketogenic diets influence aging and muscle preservation. This episode is packed with actionable insights for anyone serious about optimizing fitness, metabolism, and longevity. Learn more about Dr. Keith Baar: https://health.ucdavis.edu/physiology/faculty/baar.html

In this episode of the Heal Nourish Grow podcast, Dr. Chris Rhodes, a nutrition scientist, discusses his journey into the fields of longevity and fasting. He explains the significance of autophagy and shares his personal experiences with fasting. Dr. Rhodes also introduces Mimio, a product designed to mimic the benefits of fasting at the molecular level, and discusses the clinical studies that support its efficacy. The conversation delves into the science behind Mimeo's ingredients and their roles in promoting healthspan and longevity. Visit Mimio to learn more and get an awesome discount! Takeaways Fasting can activate longevity bio programs within our cells. Autophagy is a crucial process for cellular health and longevity. GLP-1 drugs like Ozembic may positively impact longevity pathways. Mimeo is designed to mimic the benefits of fasting without actual fasting. Clinical studies show Mimeo can improve metabolic health markers. The formulation of Mimeo includes powerful anti-aging molecules. Nicotinamide plays a key role in cellular energy and metabolism. Using Mimeo can enhance the benefits of shorter fasting periods. Maintaining a balance between mTOR activation and fasting pathways is essential for health. https://youtu.be/CidbXEJcj3k Episode transcript Cheryl McColgan (00:00.834)Hey everyone. Welcome to the Heal Nourish Grow Podcast. I don't even know the name of my own podcast. It's loving my words today. But anyway, I'm really excited about today's guest. I'm here with Dr. Chris Rhodes and he is a nutrition scientist. I'll let him better describe himself, but you will have heard his full bio, of course, before this, but I always like to start out, Dr. Rhodes, with just having you kind of share in your own words, what brought you into this space? What made you passionate about working with Mimeo Health and the technology there. Like what led you to this point? Dr. Chris Rhodes (00:32.962)Yeah, great question. Really happy to be here, Cheryl. Thanks for having me on. really got me interested into the longevity space, the healthy aging space, and eventually the fasting space was coming out of college. I got my BS in biochemistry from Leroy LaMaria Mount University, but like a lot of college kids didn't really know what I wanted to do there. So to try and figure that out, took an immunology fellowship at Stanford, just kind of pouring through all the research I could get my hands on going to all these seminars, and eventually came across the longevity research. And I thought that was so fascinating because it was this thing that used to be relegated to myth and legend, right? It was like Ponce de Leon and the Fountain of Youth. And now it's this very active, very rigorous area of scientific research with a ton of funding and a ton of companies and a ton of government and scientific attention on it. And it's one of those things that helps with everything, right? If you can solve aging, then you can pretty much also solve disease because by and large, most young folks don't get disease. really see that aging is something that's an underlying factor in every disease that happens. So if you can tackle these fundamental issues of aging at the cellular level and really slow that process down, then you can not only potentially enhance lifespan but also healthspan at the same time, which I think is what we're all really going for, living our lives as well as possible and as best health as possible for as long long as we can. When you're in the healthy aging and longevity space, eventually you come across fasting because fasting is one of the only ways that we know of to reliably extend lifespan and health span helps to treat, prevent, or delay most major diseases. And the reason why that was so fascinating to me is because it does all of that without actually adding anything into the system, right? So it's not this superfood or this wonder drug that's doing al...

Hva skal vi spise for å oppnå optimal helse? I denne episoden får du innsikt fra legen Kristin Evensen Friis, som har gjennomgått en imponerende helsereise – fra psykiske utfordringer, tretthet og fertilitetsproblemer, til å forstå hvordan kosthold kan påvirke både kropp og helsen. hva virket best på henne? Vegetarmat eller kjøttmat? Et svangeskap med vegetar og det neste med kjøtt? Hva ga best helse?Kristins reise:- Utfordringer: Fra psykiske plager, vektproblemer, tretthet og smerter til hoftedysplasi (som ble diagnostisert etter flere år med smerte). - Operasjon og smertehåndtering: Kristin har vært gjennom operasjoner og smertebehandling, som ga henne et nytt perspektiv på helse og maten hun inntok som på denne tiden var vegetarisk - både som både lege og pasient. - Kroppens og sinnets kobling: Hvordan langvarig smerte kan påvirke psyken, sosiale relasjoner, og livskvalitet.- Fra vegetarianer til animalsk kost: Etter å ha oppdaget mangler i sin kost, endret Kristin kostholdet fra vegetarisk til et mer animalsk basert. - Resultatene var imponerende: - Økt energi - Bedre konsentrasjon - Stabile blodsukkernivå - Mindre cravings og mer kontroll over sulten - Hvorfor vegetarkost ikke fungerte for Kristin: Mangel på essensielle næringsstoffer som animalsk mat gir, som vitamin B12, omega-3, jern og aminosyrer. - Kristin's Kostholdstips: Unngå UP-mat og vegetabilske oljer. - Bruk naturlige fettkilder som smør, talg og olivenolje for bedre helse og stabilt blodsukker. - Aminosyrer er nøkkelen: Hvordan tre viktigste aminosyrene påvirker helsen og hva som skjer i kroppen når vi får nok av dem. - Mat som medisin: Kristin mener mat er det viktigste verktøyet for å oppnå god helse. - Biohacking i praksis: - Anabolsk prosess, hvordan vi kan aktivere MTOR (mekanismen som regulerer vekst og reparasjon) gjennom riktig kosthold og trening. - Hvordan aminosyrer fungerer: De spesifikke aminosyrene du trenger for å optimere muskelbygging, restitusjon og hormonbalanse. - Insulinresistens: Hva skjer i kroppen når insulinresistens oppstår, og hvordan kan vi unngå det med riktig kosthold? - Optimalisering av helsen: Hvordan animalsk mat kan bidra til bedre helse, med konkrete målinger som viser forbedringer i blodverdier og energi. - Barn, kosthold og metabolisme: Hvordan barn naturlig forbrenner fett og hva de trenger for å utvikle seg godt. Hva er viktig for at barn skal utvikle seg riktig både fysisk og mentalt? Hva er viktig for deg og barna dine? - Hva er du villig til å forhandle på når det gjelder helsen din – og helsen til barna dine? Med stadig flere helseutfordringer, er det viktig å reflektere over hva vi putter i kroppen vår. - Fertilitetsproblemer og PCOS: Kristin snakker om hvordan feil kosthold kan føre til hormonelle ubalanser og fertilitetsproblemer som PCOS. -Essensielle næringsstoffer: For å være i toppform trenger kroppen dette: 9 essensielle aminosyrer, 13 vitaminer, 16 mineraler, og de riktige fettsyrene. Animalsk mat er en av de beste kildene til disse næringsstoffene. Kristin er kjent for å utfordre etablerte helsesannheter og har vært en pådriver for å fremme et mer vitenskapelig basert kosthold. Hvordan har hennes budskap blitt mottatt, spesielt i Danmark? Og hvorfor mener hun at det er viktig å tenke annerledes når det kommer til helse? Lytt til episoden og oppdag hvordan du kan optimalisere både kropp og sinn med riktig kosthold og livsstil! Du finner Kristin på insta: @dr.kristinevensenTakk til våre samarbeidspartnere:Osloskinlab.no: rabattkode: bio60gave I marsSkinome.com: BIOHACKINGGIRLS20 i marsBiohacking Weekend: https://kongresspartner.no/no/biohacking-weekend-2025Her kan du forhåndsbestille Biohacking Girls BokBIOHACKING: https://www.ark.no/produkt/boker/hobbyboker-og-fritid/biohacking-9788205611474

Dr.Andy Franklyn-Miller is a world-leading specialist in sport and exercise medicine and the Chief Medical Officer at Nuritas. He is a highly accomplished physician with expertise in physiology, clinical design, and science communication, has a Ph.D. in Biomechanics, and served in the Royal Navy and Royal Marines for 16 years. Dr. Franklyn-Miller has extensive experience in working with high-profile sports teams and elite performers, has published more than 60 peer-reviewed papers, is an editor of the British Journal of Sports Medicine, and has authored a textbook and an IOC Handbook. With his expertise in machine learning, clinical trials, and end-user analysis, he oversees several departments at Nuritas, including software engineering, data curation, data science, proteomics, lab, and regulatory departments. Together, Dr. Franklyn-Miller and I explore the science behind PeptiStrong, a groundbreaking peptide developed by Nuritas, and discuss its clinical applications and research. If you have patients who are concerned with muscle retention as they age, who aren't recovering as quickly as they would like after exercise, or who are on GLP-1 medications and need to retain lean muscle mass, this conversation will be particularly engaging to you. Together, we cover the latest peptides data and studies and what it all means for healthcare practitioners.    I'm your host, Evelyne Lambrecht, thank you for designing a well world with us.   Episode Resources: Dr. Andy Franklyn-Miller - https://www.nuritas.com/team/dr-andy-franklyn-miller/ Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 02:28 Dr. Franklyn-Miller is feeling lit up by his current data analyses. 3:00 The ability to increase health in millions of people drew Dr. Franklyn-Miller to Nuritas. 4:02 What are peptides, and what are their function and benefits related to athletic performance? 7:33 Does PeptiStrong negatively impact those with a G6-PD deficiency? 8:52 Why don't PeptiStrong peptides break down as amino acids? 11:33 Three human clinical studies and their results and mechanisms of action. 14:09 The importance and controversy of the mTOR 1 and 2 pathways. 17:19 Key findings about muscular energy from the second human study. 20:58 Factors that effectively inhibit pathways that lead to sarcopenia. 22:22 The third study examines the impact of PeptiStrong on both men and women. 24:59 The impact of PeptiStrong on reducing inflammation and the effect on TNF-Alpha and on ATP production. 28:12 Prioritizing creatine, HMB, and leucine benefits with peptides in a synergistic way. 30:27 Creating optimal impact of PeptiStrong on various patient outcomes. 33:04 Studies that will address muscle mass at each stage of a woman's life. 38:52 Clinical guidelines for taking peptides to maximize effectiveness. 40:09 Observations from Dr. Franklyn-Miller's personal experience with taking PeptiStrong. 43:36 Optimal designs for future clinical trials and the role of peptides in shaping the future of healthcare. 55:35 Dr. Franklyn-Miller's personal favorite supplements, favorite health practices, and his evolved perspective on what food and medicine are really about.

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.Sponsors:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim (book a call today)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)*Links to everything discussed: https://tim.blog/2025/02/26/dr-keith-baar/Timestamps:[00:00:00] Start [00:07:12] How I discovered Keith's work through a tweet about tennis elbow and rock climbing.[00:07:54] Emil Abrahamsson's hangboard training protocol.[00:09:20] The fundamental principles of strength training and connective tissue adaptation.[00:10:36] mTOR complex 1 and its role in muscle growth.[00:12:06] Engineered ligaments and the discovery of minimal effective doses for tendon adaptation.[00:13:50] The refractory period between optimal tendon loading sessions.[00:16:42] Rapamycin's effects on muscle hypertrophy.[00:18:49] Protocols for tennis elbow rehabilitation.[00:20:28] Why isometrics work better than eccentrics for tendon healing.[00:22:14] Stress shielding and how load distribution affects tendon healing.[00:29:07] The misconception about eccentric loading for tendon injuries and why velocity matters.[00:29:58] Ideal duration for isometric holds (10-30 seconds) based on injury status.[00:33:50] My elbow issues and current rehab approach.[00:36:02] Overcoming vs. yielding isometrics and optimal loading strategies.[00:47:11] Dr. Barr's movement prescription for my tennis elbow.[00:52:18] Loading timing post-surgery and RICE protocol criticism.[00:56:58] Achilles tendon rehabilitation after surgery.[01:00:18] Critique of orthopedic suturing techniques and recommendation for resorbable sutures.[01:04:02] Multiple position isometrics for tennis elbow rehabilitation.[01:07:26] Collagen synthesis, supplementation, and vitamin C timing.[01:12:59] Critique of BPC-157 and other injectable peptides for tendon healing.[01:18:19] Evaluation of orthobiologics' (PRP, prolotherapy, stem cells) effectiveness.[01:21:37] JAK-STAT inhibitor drugs and their effects on tendon growth.[01:25:35] Drugs that increase risk of tendon ruptures (fluoroquinolones, AT-1 receptor drugs).[01:29:33] How estrogen affects tendon stiffness and injury risk in women.[01:32:48] Testosterone's opposite effects on tendon compared to estrogen.[01:35:31] Protein intake recommendations and timing.[01:40:11] Ketogenic diet effects on mitochondrial biogenesis and longevity.[01:41:57] Comparison of ketogenic diet, low protein diet, and rapamycin for longevity.[01:47:19] Inflammation's role in adaptation and when to reduce it.[01:51:17] Timing of ice baths relative to training for optimal recovery.[01:52:33] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

TIME STAMPS:00:43 Inspiration behind the 2nd annual ULTIMATE MEN'S HEALTH RETREAT *details & signup info* https?//umhr.co.uk03:14 WIM HOFF, DORIAN YATES, RICHARD SMITH & other legendary keynote speakers!09:18 The A.L.P.H.A. (anabolic leverage protein and hormone activation) diet; summary of Al Reeve's cyclical keto diet for lean bulking!13:35 How C8 Medium Chain Triglycerides stimulates endogenous ketone production and why ketogenic performance is increased as a result.14:31 The difference between C8, C10, & C12 - everything fat-adapted athletes need to know about fatty acid metabolism to optimize ketosis! 16:06 Supplemental vs. natural MCT sources, and how Richard invented the world's most concentrated C8 powder (99.9% purity!)18:45 Exogenous ketones & OMAD; important timing tips to make sure you don't store fat faster than you burn it off!!!22:05 MONOCARBOXYLATE TRANSPORTERS (MCTs - not to be confused with medium chain triglycerides!) are a family of proton-linked membrane transporters that facilitate the transport of monocarboxylate molecules such as lactate, pyruvate, and ketones across biological membranes. Richard teaches their critical role for fat adapted athletes in an effort to increase their performance and muscle mass starting with an increase in cell mitochondria!30:30 Maximizing HGH & MTOR. - The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. 33:33 ZINC can be blocked by as much as 100% if it is eaten with PHYTIC ACID (mainly whole grains, beans, nuts, seeds, and many vegetables)/35:45 FACT - broccoli damages your DNA!!! **PER RICH, STAY TUNED FOR MORE ON THIS NEXT WEEK**39:02 The truth about GENETICS and EPIGENETICS in bodybuilding (EPIGENETICS  is defined as the study of Heritable traits or stable changes in cell function that happen without changes to the DNA sequence).47:05 L.I.S.S. BAD COACH CALLOUT (Calories-in-Calories-Out) & Podcast Review - thanks Rusty! @ rustybbqlamb49:04 Dr. Rick Buchikos, from San Francisco / IG rickbuchikos / nutritiontechnician.net / Dr. Rick is a Functional Medicine Doctor and Human Nutritionist raising awareness of the corruption in the medical system! LEAN BULKING questions around MACROS, GUT SENSITIVITY and other complications!53:03 Protein supplementation on the lion diet - friendly debate!01:01:21 ZINC and TAURINE for digestion as a possible improvement over BILE SEQUESTRANTS and other non-natural digestion aids.01:04:04 C8, MCT & Exogenous Ketones - how to mix them and get the best results with what you have access to.01:08:09 PEPPERMINT OIL and other hacks to make your ketone drinks tastier and more practical within your lifestyle! Tips on public speaking, music, and other performance situations besides sports where electrolytes are helpful and how to use them.01:13:52 All of the DETAILS AND SIGNUP INFO for the retreat! ( again see website https?//umhr.co.uk )01:15:20 Morgan McCarthy - Midwest Family Broadcasting - thanks and thoughts from Rich on how to use your Keto Pro ketones!

In this episode, I sit down with Dr. Adam Bataineh, a top expert in preventative healthcare and longevity. If you've ever wondered whether aging is really inevitable or if there's a way to slow it down (or even reverse it), this is the episode for you.We're talking cutting-edge science, biohacking tricks, and real-world strategies to help you live longer, healthier, and stronger. Dr. Adam breaks down everything from why aging is the root cause of most diseases to how to track your biological age like a pro.So, grab your coffee, matcha, or protein shake, and let's dive in.What You'll Learn in This EpisodeAging and disease – Why aging is behind diseases like cancer, heart disease, and metabolic issuesMuscle vs. longevity – Should you build more muscle or focus on calorie restriction? (Spoiler: balance is key)VO2 max and lifespan – The one fitness metric that predicts how long and well you'll liveBiohacking and longevity drugs – Rapamycin, Ozempic, and other tools that could change the gameWhy one-size-fits-all health advice doesn't work – How personalized medicine is the futureBig Takeaways from the EpisodeAging is not set in stone. Science is proving that we can slow it down or even reverse it with the right strategies.Muscle is a longevity cheat code. It's not just about looking strong; muscle mass helps regulate blood sugar and metabolic health.VO2 max is king. Want to know your true health status? Start tracking your cardio fitness level.Timing is everything. Sleep in a cool, dark room, get sunlight early in the day, and avoid late-night meals for better health.Supplements and drugs can help, but lifestyle is key. Tools like rapamycin, GLP-1 agonists, and omega-3s are promising, but they're not magic.5 Things You Can Do Today to Improve Your Health and LongevityTrack your biomarkers. Get regular blood tests, check your VO2 max, and monitor your health like a biohacker.Move more, sit less. Strength training and cardio are the best anti-aging formulas.Align with your circadian rhythm. Get morning sunlight, avoid blue light at night, and optimize your sleep.Be mindful of mTOR and calories. Fasting, eating protein at the right times, and avoiding overeating can boost longevity.Dial in your supplements. If you're lacking key nutrients, consider omega-3s, magnesium, or creatine to support your health.

Summer Series: Most of us want to live longer, healthier years. Research is indicating that our longevity is no more just about the genetic cards we are dealt, but actually we have more controllable elements at our finger tips than ever before. Host Amelia Phillips and Dr Norman Swan, a multi-award winning producer, broadcaster and Physician journalist, discuss the latest longevity and anti-aging research. They also discuss the latest on supplements and therapies such as Metformin, NAD, NMN, resveratrol, mTOR and rapamycin. They discuss simple lifestyle changes to diet, exercise, and education that can dramatically improve longevity, plus the anti-aging skin treatments, and BAG (brain age gap) therapies, to protect our brain from the effect of ageing. So You Want To Live Younger Longer Dr Norman's New Book, now available. Badie Winkle: Instagram granny - Amelia wants to have her energy at 94! David Sinclair Lifespan Podcast: Deep dive into longevity medicines. About the guest: Dr Norman Swan, a multi-award winning producer, broadcaster and Physician journalist. He hosts two popular podcasts; The Health Report and Coronacast, which won a walkley award last year. He is one of Australia’s most trusted doctors appearing regularly in the media to help disseminate the large amount of confusing health research. About the host: Amelia Phillips is an exercise, nutrition, parenting and business expert with a career spanning 26 years in health. She's a registered exercise scientist, nutritionist and researcher (with a masters of human nutrition). She is the co-founder of health tech company 12WBT which grew from start-up. After a successful exit, she now consults to health companies, presents and appears in the media. Amelia had four kids in five years and is dedicated to empowering women to build a life after kids on the foundation of health (mental and physical), love and purpose. If you have a question for Amelia, reach out via Insta @_amelia_phillips, email ap@ameliaphillips.com.au or text an audio question to: 0417458772 Find out more at www.ameliaphillips.com.au CREDITSHost: Amelia Phillips Guest: Dr Norman SwanAudio Producer: Darren RothMusic: Matt Nicholich Production Partner: Nova Entertainment Pty Ltd Healthy Her acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present and extend that respect to all Aboriginal and Torres Strait Islander cultures. See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

EP. 190: What if the key to not dying early—or at least living vibrantly—boils down to one thing? Metabolic health. In this episode, I sit down with Dr. Ben Bikman, one of the world's leading experts on insulin resistance & metabolic health. Dr. Bikman is a professor at Brigham Young University and the author of Why We Get Sick, a groundbreaking book that exposes how modern lifestyles are fueling diabetes, obesity, and heart disease. We break down: Why insulin resistance is the root cause of so many chronic conditions The real impact of GLP-1s on metabolism and fat cells The latest cutting-edge research on muscle and GLP1 from Dr. Bikman's lab at BYU What you can do today to take back control of your metabolic health How Insulin Resistance Fuels Chronic Disease—and What to Do About It The Surprising Role of Fat Cells in Metabolism and Hormone Balance Why ‘Eat Less, Move More' Fails Most People—and What Works Instead GLP-1s and Satiety: The Science Behind Appetite and Metabolic Control Cutting-Edge Metabolic Health Research from BYU That Could Change Everything Simple, Science-Backed Strategies to Boost Testosterone Naturally If you care about your hormones, metabolism, and long-term vitality, this episode is a must-listen. Join my FREE 21-Day Strength & Resilience Challenge to get started: www.drtyna.com/strengthandresilience Sponsored By: Timeline Timeline is offering 10% off your order of Mitopure. Go to timeline.com/drtyna.  Puori Go to Puori.com/drtyna and use code DRTYNA to get 20% off Purity Woods Go to puritywoods.com/DRTYNA or enter DRTYNA at checkout for 27% off Sundays Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. BIOptimizers For an exclusive offer go to bioptimizers.com/drtyna and use promo code DRTYNA On This Episode We Cover:  00:00:00 - Introduction 00:01:57 - Teaching at BYU 00:03:32 - Dr. Ben's books 00:05:42 - Defining insulin resistance 00:10:14 - Insulin resistance and chronic disease 00:17:50 - Viruses and fat cells 00:19:56 - Fast vs. slow insulin resistance 00:26:21 - Overfilled fat cells 00:28:24 - Issues with the “Eat less & exercise more” approach 00:31:27 - Genes and metabolic health 00:32:12 - Satiety & GLP-1 response 00:37:25 - Appetite control vs. suppression 00:39:22 - GLP-1 dosing 00:42:33 - Hormones and metabolism 00:48:13 - Estrogen replacement therapy and testing 00:51:57 - AMPK, mTOR, and supplementation 00:57:57 - Metformin study 00:59:46 - Easiest ways to increase testosterone Further Listening: 10 Health Trends We Are Ditching in 2025 | Solo Kick Off 2025 with Strength, Resilience & Purpose | Quick & Dirty The Surprising Health Connections Between You and Your Dog | Quick & Dirty Check Out Dr. Ben: Instagram Website Books Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Dirige y presenta Juan Carlos Baruque Hernández Sumario del programa DANIEL GARCÍA C Con Daniel nos meteremos, una vez más, en camisas de once varas hablando de las nuevas medidas dictatoriales impuestas desde el ámbito político y que atacan, cómo no, a las libertades individuales del ciudadano de andar por casa. ALBA LOBERA Alba nos hablará de esa falta de capacidad que tienen algunas personas para no perdonarse así mismas por los errores cometidos. JOSÉ CARBONERAS José Carboneras nos explicará que son y que pueden hacer para nuestra saludo las toda poderosas proteínas mtor. Nuestra Web: https://mundoinsolitoradio.es Contacta: +34 687 39 80 12 - Solo WhatsApp mundoinsolitoradio@hotmail.com Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Balancing AMPK and mTOR for Optimal Aging and Performance Episode Summary: In this episode, we dive into the fascinating world of cellular pathways—AMPK and mTOR—and how they influence mitochondrial function, muscle protein synthesis, and the aging process. Discover how to strategically balance these pathways to optimize metabolic health, overcome anabolic resistance, and support muscle maintenance as we age. Learn actionable tips for nutrition, exercise, fasting, and recovery to enhance your body's performance and longevity. What You'll Learn in These Episodes: The role of AMPK in fat oxidation, autophagy, and mitochondrial health. Why mTOR is crucial for muscle protein synthesis and recovery. How to cycle between AMPK and mTOR activation daily and weekly. Nutrition strategies for protein timing, carbohydrate fueling, and fat balance. Recovery practices like fasting, heat exposure, and cold therapy to optimize cellular health. Supplement recommendations to support both pathways. Key Takeaways: AMPK-focused mornings: Fasted low-intensity exercise and nutrient-dense meals for fat oxidation and autophagy. mTOR-focused midday: Strength training and leucine-rich protein for muscle growth and recovery. Weekly cycling: Alternate between AMPK and mTOR-dominant days to maintain balance. Optimize aging by addressing anabolic resistance with protein-rich meals and targeted recovery practices. Resources Mentioned: Supplements: Berberine, resveratrol, leucine-rich protein, EAAs, and creatine. Recovery tools: Cold plunges, sauna, and intermittent fasting. Nutrition insights: High-quality protein sources, carb timing, and omega-3 fats. Who This Episode Is For: This episode is perfect for anyone looking to optimize their body composition, improve mitochondrial function, and thrive as they age—whether you're an athlete, health enthusiast, or just looking to stay strong and resilient. Connect With Us: Website: www.debbiepotts.net Social Media:  Coach Debbie Potts Don't forget to subscribe, leave a review, and share this episode with someone who's passionate about living their best life!

This week, I'm joined by the father of biohacking, Dave Asprey. The pioneer behind the global movement that has transformed the way people optimise their health and performance. With decades of experience in biohacking, Dave has authored multiple bestsellers and founded companies that have redefined wellness, longevity, and cognitive enhancement.In this episode, Dave shares his personal journey to optimised health, revealing how he lost 100 pounds, overcame chronic health issues, and built a lifestyle that enhances both mental and physical performance. We explore the fundamentals of biohacking, from AI-driven strength training to the science of caffeine optimisation and the critical role of heart rate variability in achieving peak performance. Dave also breaks down popular wellness trends, tackling topics like the impact of hormonal health, the truth about supplements, and the evolving landscape of modern nutrition. Whether it's uncovering the potential of mouth taping for better sleep, exploring the latest in light therapy for hair health, or navigating the micro-plastic crisis, Dave offers practical insights to help listeners take control of their biology.00:00 Biohacking fundamentals02:17 Where weightlifting meets longevity science04:00 Dave's personal path to optimised health05:32 Smart training and recovery techniques08:04 How AI is transforming strength training14:19 The deeper science of caffeine optimisation19:20 Understanding HRV's role in peak performance24:55 Unlocking better cognitive function28:42 The complex dance of mTOR, muscle, and ketosis36:39 Importance of hormonal health through blood work41:48 Which supplements aren't worth your money?43:07 The truth about sponsor influence in the health industry44:08 Challenging common vegan nutrition myths47:33 Traditional diets vs modern eating habits51:10 Fresh insights on carbs and nitric oxide53:09 Why mouth taping could transform your sleep55:20 Essential wisdom on salt and hydration1:01:48 Breaking down the Ozempic controversy1:07:38 Understanding our microplastic crisis1:09:57 Practical tips for plastic-free living and beating jet lag1:19:19 Myths about sparkling water and hair health1:27:24 The science behind light therapy for hair1:30:08 Taking on the biggest aging challenges1:35:01 Key takeaways from Dave's latest book1:40:00 Building better habits through HRV» Escape the 9-5 & build your dream life - https://www.digitalplaybook.net/» Transform your physique - https://www.thrstapp.com/» My clothing brand, THRST - https://thrstofficial.com» Custom Bioniq supplements: https://www.bioniq.com/mikethurston   • 40% off your first month of Bioniq GO   • 20% off your first month of Bioniq PRO » Join ​⁠@Whoop and get your first month for free - https://join.whoop.com/mikethurston» Follow Dave«Instagram: https://www.instagram.com/dave.asprey/?hl=enX: https://x.com/daveasprey?lang=enWebsite: https://daveasprey.com/

Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the AMPK pathway acts as a guardian of energy preservation in the cell, especially under conditions of low nutrient availability, while mTOR is pivotal for muscle protein synthesis and energy expenditure. They also touch upon the impact of gut microbiome shifts on insulin sensitivity and how products like berberine and metformin can influence these pathways, sometimes to the detriment of muscle mass gain. Metformin and Gut Microbiome Positive impacts of metformin on gut microbiome GI disturbances related to insulin mimetics Role of AMPK signaling in energy preservation and muscle protein synthesis Benefits of products like berberine, banaba leaf extract, and alpha lipoic acid Hormonal support and muscle mass considerations   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by  @marekhealth : Performance. Longevity. Optimization.

What, you may ask, is TSC. When I first met our guest, Kari Luther Rosbeck, I had the same question. TSC stands for tuberous sclerosis complex. As soon as Kari defined the term for me it struck a nerve close to home for me. My great nephew actually has tuberous sclerosis complex and was first diagnosed with this rare disease when he was but a child. My conversation with Kari was far reaching and quite educational for me as I suspect it will be for you.   TSC affects some fifty-thousands persons in this country and about 1 million around the world. The TSC alliance, founded in 1974, has worked to promote support, research and the dissemination of information about this rare disease.   Kari has been the CEO for many years. She began with the organization in 2001. While her main interest growing up was in being an actress as she says, “living in New York City means that you work while developing an acting career”. In Kari's case, she found another interest which was fundraising and being involved in the nonprofit world.   My conversation with Kari is quite enjoyable and, as I said, quite educational. I am sure you will find much invaluable information in this episode. At the end of our time together Kari will tell us all how we can become involved and help the TCS Alliance. I hope you will find ways to support this effort as what the organization does goes far beyond what you might think.       About the Guest:   Kari Luther Rosbeck, President and CEO, TSC Alliance Kari has made it her life mission to use her 35 years of nonprofit and volunteer management experience to help create a future where everyone with TSC has what they need to live their fullest lives.  She has served as President and CEO since November 2007 and previously held progressive leadership positions with the organization since 2001. Kari is responsible for the overall management and administration of the organization including strategic planning, implementation of organizational strategies and evaluation of results to ensure the TSC Alliance meets its mission. During her tenure, the TSC Alliance established a comprehensive research platform fostering collaboration with industry and academia to move treatments for TSC forward in a more expedited way. Because of her leadership, the organization has taken an active role in educating the TSC community about clinical trials to diminish the time for recruitment, including pivotal trials that have led to three FDA-approved drugs specifically for TSC. In 2019, the organization launched a Research Business Plan with the goal to change the course of TSC for those living with it today and for generations to come paired with an aggressive fundraising campaign leading to more than $16 million raised. Since joining the TSC Alliance, the organization has grown from a $2.1 million annual operating budget to $10 million in 2022 and is heralded with top ratings by watchdog organizations. Kari graduated with a BA degree in Theatre from the State University of New York at Albany and upon graduation founded a theatre company with fellow graduates in New York, NY.  After the loss of her first child, Noell, to sudden infant death, she dedicated her career to helping other families. Kari is the proud mother of Trent, Bradey, Wynter and Rhys and grateful to her husband Chris for his unending support. When not working, she enjoys traveling, playing golf and being an avid Minnesota Vikings fan. Read Kari's Profile in Success.   Ways to connect with Kari:   Facebook: https://www.facebook.com/tscalliance; @krosbeck Instagram: https://www.instagram.com/tscalliance; @karirosbeck LinkedIn: https://www.linkedin.com/company/697362/admin/; @kari-luther-rosbeck-ba24805/ X: https://twitter.com/tscalliance; @KariRosbeck Threads: https://www.threads.net/@tscalliance Website: www.tscalliance.org     About the Host:   Michael Hingson is a New York Times best-selling author, international lecturer, and Chief Vision Officer for accessiBe. Michael, blind since birth, survived the 9/11 attacks with the help of his guide dog Roselle. This story is the subject of his best-selling book, Thunder Dog.   Michael gives over 100 presentations around the world each year speaking to influential groups such as Exxon Mobile, AT&T, Federal Express, Scripps College, Rutgers University, Children's Hospital, and the American Red Cross just to name a few. He is Ambassador for the National Braille Literacy Campaign for the National Federation of the Blind and also serves as Ambassador for the American Humane Association's 2012 Hero Dog Awards.   https://michaelhingson.com https://www.facebook.com/michael.hingson.author.speaker/ https://twitter.com/mhingson https://www.youtube.com/user/mhingson https://www.linkedin.com/in/michaelhingson/   accessiBe Links https://accessibe.com/ https://www.youtube.com/c/accessiBe https://www.linkedin.com/company/accessibe/mycompany/   https://www.facebook.com/accessibe/       Thanks for listening!   Thanks so much for listening to our podcast! If you enjoyed this episode and think that others could benefit from listening, please share it using the social media buttons on this page. Do you have some feedback or questions about this episode? Leave a comment in the section below!   Subscribe to the podcast   If you would like to get automatic updates of new podcast episodes, you can subscribe to the podcast on Apple Podcasts or Stitcher. You can subscribe in your favorite podcast app. You can also support our podcast through our tip jar https://tips.pinecast.com/jar/unstoppable-mindset .   Leave us an Apple Podcasts review   Ratings and reviews from our listeners are extremely valuable to us and greatly appreciated. They help our podcast rank higher on Apple Podcasts, which exposes our show to more awesome listeners like you. If you have a minute, please leave an honest review on Apple Podcasts.       Transcription Notes:   Michael Hingson ** 00:00 Access Cast and accessiBe Initiative presents Unstoppable Mindset. The podcast where inclusion, diversity and the unexpected meet. Hi, I'm Michael Hingson, Chief Vision Officer for accessiBe and the author of the number one New York Times bestselling book, Thunder dog, the story of a blind man, his guide dog and the triumph of trust. Thanks for joining me on my podcast as we explore our own blinding fears of inclusion unacceptance and our resistance to change. We will discover the idea that no matter the situation, or the people we encounter, our own fears, and prejudices often are our strongest barriers to moving forward. The unstoppable mindset podcast is sponsored by accessiBe, that's a c c e s s i capital B e. Visit www.accessibe.com to learn how you can make your website accessible for persons with disabilities. And to help make the internet fully inclusive by the year 2025. Glad you dropped by we're happy to meet you and to have you here with us. . Well, welcome once again to another episode of unstoppable mindset where inclusion, diversity and the unexpected meet, and I bet we get to do a bunch of all of that today. Our guest is Kari Luther rosbeck, and Kari and I met through Sheldon Lewis from accessibe. Sheldon is great at finding folks for us to get to chat with. And when I started learning about Kari, one of the things that I kept reading was a term TSC, and I didn't know what TSC was. So when Kari and I first met, I asked her about TSC, and she said it stands for tubular sclerosis complex, which immediately struck a nerve with me, because I have a great nephew who has tubular sclerosis. And as it turns out, his parents have actually and had actually attended an event where Kari was and then just this past March or April or whenever, and you can correct me, Kari, but they went to another event, and my other niece and nephew, Tracy and Charlie, attended, as I just told, Kari, I'm very jealous they didn't let me come along, but that's okay. I stayed home and slept. But anyway, Kari, I want to welcome you to unstoppable mindset. It's really great that you're here, and I want to thank you for taking the time to be with us. It   Kari Luther Rosbeck ** 02:42 is such an honor. Michael and I love talking with your family, and it was so wonderful to have them with us at comedy for a cure this year. Well, it   Michael Hingson ** 02:53 it was really fun to hear about the event from them, and I'm glad that that they all enjoyed it. And of course, Nick is is a person who deserves all the attention and help all of us can give. He's had tubular sclerosis, been diagnosed with it for quite a while, and is actually, I think, beating some odds, because some people said, Oh, he's not going to last very long, and he's continuing to do well. And just don't ever get him into a conversation about sports and the Dodgers, because he's a Dodger fan, okay,   03:24 as he should be. By the conversation.   Michael Hingson ** 03:28 Well, he is a Dodger fan as he should be. I just want to point that out, yes, yes, for those of us here. Well, Nick, Nick probably   Kari Luther Rosbeck ** 03:36 was, well, when Nick was diagnosed, we had a very different prognosis for TSC back then.   Michael Hingson ** 03:45 Well, yeah, I know, and it's like everything with medicine, we're making a lot of advances. We're learning a lot, and of course, we're paying a lot of attention to these different kinds of issues. I mean, even blindness, we're paying a lot of attention to blindness, and we're slowly getting people it's a very slow process, but we're slowly getting people to recognize blindness isn't the problem. It's our attitudes about blindness that are the problems. And I think that's true with most things, and I think that if people really thought about Nick and and felt, well, he can't do much because of they would recognize he can do a whole lot more than they think he can, 100% which is really important. Well, let's start a little bit about you. And why don't you tell us about the early Kari growing up and all that and how we got where we are, well, thank   Kari Luther Rosbeck ** 04:43 you for the opportunity to do that. My middle name is Lacher. That's also my maiden name. My dad and mom were in education, primarily. My dad also dabbled in some politics. We moved around. Quite a bit when I was a child, I think before seventh grade, or before I was 18, we knew 13 times so that really, you know, you become adaptable because you have to be and inclusive, because you have to be because you're in all of these new environments. From the time I was six years old, I wanted to be an actress. I wrote my own plays, I organized a neighborhood, I think, when I was seven, and we performed a play I wrote. And that's what my degree is in, in theater. And Michael, as you probably know, when I was 27 I had my first child, Noel, who unfortunately passed away from sudden infant death, and it completely changed the rest of my life. From that point forward, I really wanted to do something that impacted families, so they never had to experience the type of grief that I went through at a very somewhat young age. And then from from that point, I took all of the skills that I'd been using in the work life, not theater, because I lived in New York, and you have to work to live, so you could do theater before my then husband and I moved to Minneapolis, but I had always done fundraising. I had always done administration, so I just kind of naturally took in all of those skills, community and grassroots building. I went to work for the American Refugee Committee in Minneapolis, and then from there, worked at international service agencies, which is a workplace giving umbrella organization representing all of the premier international organizations. And my job there, as a regional director was to go into workplaces and give two or three minute presentations and convince people to give to international causes. My favorite was I was pregnant. I had a pregnancy kit, what they would give people in developing the developing world, where you would have a razor blade, a string, a plastic sheet, and that's how they delivered babies. And that was a really effective presentation, as you can imagine. I got to the TSC Alliance because my boss at international service agencies became the CEO of the TSC Alliance in early 2000s and he brought me over to start our volunteer outreach program, build our grassroots movement, and from there, I definitely got involved in fundraising. The admin side was interim CEO, and then CEO,   Michael Hingson ** 07:55 well, gee, so so many questions. Why did you guys move so many times?   Kari Luther Rosbeck ** 08:01 Well, my dad got his PhD and became dean of students at Arkadelphia State University, or Henderson State University in Arkadelphia, rather. And he did great, but he loved politics, and he had the opportunity to become the executive director of the Republican Party of Arkansas when it wasn't cool to be a Republican in Arkansas, and that really was his passion. And from there, he became a he led a congressional campaign for a candidate in Littleton, Colorado, and when that candidate didn't win, he realized that he really needed to have a more stable life for his family. So we moved to Knoxville, Illinois, and he became a vice president at a community college, and from that point forward, that was his his career. We moved to upstate New York. I'm leaving out a few moves just to make it simple. We moved to upstate New York my freshman year in college, where he became a President of Community College there, and then ultimately, he ended back in his hometown, in Mattoon, Charleston, Illinois, where he led the local community college until he retired, and the Student Union at Lakeland College is actually named after my   Michael Hingson ** 09:30 father. Wow. So is he still with us today? He is not.   Kari Luther Rosbeck ** 09:34 He passed away from idiopathic pulmonary fibrosis in 2017   Michael Hingson ** 09:38 Well, that's no fun. How about your mom? She is, she   Kari Luther Rosbeck ** 09:43 still lives in that soon. Yep, she is the matriarch of our family. That's for sure.   Michael Hingson ** 09:50 A lot of moves. Needless to say, I wonder what your father would say about politics today, it started to be different in 2016 and. 2017 but I wonder what he would think about politics in general. Today, I   Kari Luther Rosbeck ** 10:04 am not sure. I have wondered that question a lot. The one thing my dad was always great at, though, was the ability to see balanced viewpoints, and it's something I always loved and respected about my father, and   Michael Hingson ** 10:19 I think that's important. I think people really need to do more of that. And we just, we're not, we're not seeing that, which is really scary. We're not seeing it on so many levels, not just politics. But, you know, we don't get into politics much on unstoppable mindset, because, as I love to tell people, if we do that, I'm an equal opportunity abuser anyway, and and I, and I'm with Mark Twain. Congress is that grand old benevolent asylum for the helpless. So you know?   Kari Luther Rosbeck ** 10:48 Well, I will say this. My dad taught me how to be an advocate from a very young age. Yeah, what it means to not be afraid to use your voice. That's the best thing we can get out of politics, that using your voice for the greater good is one of the most important things that you can do. The   Michael Hingson ** 11:10 thing that I think people are forgetting today is they love to use their voice, but they don't love to use their ears. Yes, which is another thing, but I I hear what you're saying. I joined the National Federation of the Blind, which is the largest blindest consumer organization in the country, and I joined in 1972 when I was a senior in college, and learn from experts about being an advocate. And I think it's really important that we have advocacy. And the value of really good advocates is that they are able to look at all sides of an issue and really make intelligent decisions and also recognize when it's time to maybe change as things evolve in terms of views. And we just don't see any of that today. People say I'm an advocate. Yeah, well, without thinking about it, and without really looking at the options, and without looking at stands, it's just amazing how people, as I said, use their voices, but not their ears today. I agree. Yeah, it's, it's, it's a tough world, and it's, it's a challenge. I read an article about a year ago in the New York Times all about how we're losing the art of real conversation, which is why this podcast is so much fun, because we do get to converse.   Kari Luther Rosbeck ** 12:36 That's right, I I'm so excited to be with you today.   Michael Hingson ** 12:40 Well, so you got into nonprofit, in a sense, pretty early, and you've certainly been involved at reasonable levels for now, 23 years after September 11, I worked at Guide Dogs for the Blind for six and a half years, as well as being a public speaker. But loved working in the nonprofit sector, although I had a lot of fun with some of the nonprofit people, because what I would constantly advocate, if you will, is that development in the nonprofit world is really just no different than sales. Instead of selling and making a profit, in a sense, you're selling to secure donations, but it's still sales. And people would say, Oh no, it's totally different, because nonprofit is just totally different than what you do if you're working with a company and selling for a company. And I'm going, I'm not sure it's that different.   Kari Luther Rosbeck ** 13:40 Well, what I think is that you're selling hope and right? It's all about relationships. But unlike widgets, we have a lot of different programs that have created such progress, hope and support for the tuberous sclerosis complex community. And I really enjoy talking about what those programs help make possible for people like your great nephew, Nick well   Michael Hingson ** 14:12 and and it's important to do that. I The only thing I would say on selling widgets, as opposed to hope, is if you talk to Steve Jobs or Bill Gates, they would say that widgets very well could also be a mechanism to to move toward hope and dreams. And so again, I think it's just, it's it's all using the same techniques, but different things. I tell people now that as a keynote speaker, I think it's a whole lot more fun to sell life and hope and dreams than it is to sell computer hardware.   Kari Luther Rosbeck ** 14:54 But you're right about computer hardware, and for instance, wearables that are. Really making a difference in some of the breakthroughs that we see today. So under percent correct.   Michael Hingson ** 15:05 Well, tell us a little bit about the whole tubular sclerosis complex Alliance, the TSC Alliance, and you got started in it. And what was it like, if you will, back in the day, and it's not a great term, I'm telling you, I I'd love to to have fun with that, but what it used to be like, and what it is now, and what's happening, sure.   Kari Luther Rosbeck ** 15:27 So when I started June 18, 2001 nearly 23 years ago, the organization had about seven employees. Today, we have 23 we in those days, we knew what the genes were in TSC, and soon after I came to work, we discovered how the TSC genes impact the underlying genetic pathway. That was awesome, because that led to some key clinical trials and ultimately an approved drug. What I say about the early days is we were we did a beautiful job of holding people's hands, offering them support, but there were no medications that really directly impacted TSC that were FDA approved,   Michael Hingson ** 16:21 maybe it would help if we actually define what TSC is. Yes, of   Kari Luther Rosbeck ** 16:25 course, let's start with that. Tuberous sclerosis complex is a rare genetic disorder that causes tumors to grow throughout the body, the brain, heart, kidney, liver, lungs. It is the leading genetic cause of epilepsy and one of the leading causes of autism. Epilepsy impacts about 85% of people with TSC autism, about 50% one in 6000 life first will have TSC. TSC impacts about 50,000 Americans and a million people worldwide, and it's variable. No two people are exactly the same, not even identical twins. So people can have mild cognitive impact. They might have moderate or severe. People can have mild cognitive impact, but at some point in their life, perhaps needing a lung transplant. TSC is progressive. So for women of childbearing age, lymph angiolio, myomatosis, or Lam can impact the lungs. We can see kidney growth of tumors in the kidneys that can impact quality of life. So it's variable, and some of our adults live independently. Others require more complex care. It's usually diagnosed in childhood and in infancy, either in utero, where you can see two or more heart tumors in a regular ultrasound. Sometimes you're diagnosed after birth, when a baby begins having seizures. Some people aren't diagnosed till they're teenagers with the appearance of angiofibromas or skin tumors on their face. And occasionally, people are diagnosed when they're adults. They have kids of their own, their children are diagnosed with TSC, and then they are subsequently diagnosed with TSC. So it runs the gamut.   Michael Hingson ** 18:31 So it is something that very much is or can be genetic. It is genetic.   Kari Luther Rosbeck ** 18:38 Yes, it's caused by mutations in one of two genes, TSC one or TSC two, on the ninth or 16th chromosome that controls cell growth and proliferation, which is why you see the appearance of non malignant tumors. And that is what impacts all the organ systems. Yeah,   Michael Hingson ** 19:00 and it is not a fun thing, needless to say, to be around or to have, and it's not something that we have control over. Nick, I know does live with his parents. I don't know whether Nick will ever be able to live independently. He does have seizures and sometimes, and it's not predictable, although he's doing a little bit better job of controlling them with medication, but he'll probably always live with someone. But what a wonderful person to have around. Yes,   Kari Luther Rosbeck ** 19:35 he is definitely enjoyable. And that's, I mean, that's the thing about TSC. We have we have independent adults. We have kids, we have semi dependent adults. We have dependent adults. The one thing about our community and our organization is this is a home for everybody.   Michael Hingson ** 19:58 So when did the. See Alliance actually first begin   Kari Luther Rosbeck ** 20:01 1974 so it started with four moms around a kitchen table in Southern California, and two of those four moms are still in touch with the TSC Alliance. I talked to two of our Founding Moms quite frequently. They are very inspirational. They had this tremendous foresight to think about what the community needed or what they would need in the future. So our organization, the TSC Alliance, we actually have a new vision statement as of this year. So our vision statement is the TSC Alliance wants to create a future where everyone affected by TSC can live their fullest lives, and our mission statement is to improve quality of life for everyone affected by tuberous sclerosis complex by catalyzing new treatments, driving research toward a cure and expanding access to lifelong support. What so some of the ways that that we do this, as you know, is to fund and drive research, to empower and support our community, to raise awareness of TSC, because we want to provide the tools and resources and support for those living with TSC, both individuals and caregivers. We want to make sure that as an organization, we are pushing research forward by a research platform that we've helped create through the years, and we want to make sure that people are diagnosed early and receive appropriate care. So it's really important to us to raise awareness in the general public, but also among the professional community.   Michael Hingson ** 21:52 So this is the 50th anniversary of the TSC Alliance. Yes, it is. And I would dare say, based on what you're talking about, there's a lot to celebrate.   Kari Luther Rosbeck ** 22:04 We have so much to celebrate. Michael, there's been so many accomplishments over the years, from the creation of our professional advisory board early on that provided guidance to the organization to today, we have three FDA approved drugs specifically to treat TSC as an organization in 2006 we started the very first natural history database anywhere in the world that still exists today, with over 2700 participants, and that allows us to really understand how TSC progresses through a lifetime, and then we, as an organization, in partnership with a group of our TSC clinics, helped with the first preventative clinical trial for epilepsy in the United States, and that was really to look at Babies with TSC to treat them before the first seizure, to see if we can prevent or delay epilepsy.   Michael Hingson ** 23:07 So So tell me a little bit about the the three different drugs that are available. What? What do they do? Without getting too technical, how do they work, and so on, because, obviously, the tumors are there. And so what do the drugs do to address all of that   Kari Luther Rosbeck ** 23:24 great question, the first approved drug for TSC everolimus is an mTOR inhibitor, mammalian target of rapamycin. So if you remember I talked about the two TSC genes working as a complex to control the genetic underlying genetic pathway. Well, that underlying genetic pathway is mTOR, and there happened to be a class of drugs that was developed to help with organ transplant and anti rejection. Ever roll. This is a synthetic of rapamycin that was found on rap a rap the islands, rap immune island. So what that particular drug has been approved for, and how it works in TSC is to shrink certain types of brain tumors to shrink tumors in the kidneys, and it's also used as adaptive therapy for seizures associated with TSD. So what we know is it is extremely effective, but if you go off the medication, the tumors will grow back. So it's not a cure, but it's moving in the right direction, right second drug that was approved is the first FDA cannabinoid drug, Epidiolex, and that treats seizures associated with TSC. The third approved drug is a topical rapamy. So it treats those skin tumors on the face. I   Michael Hingson ** 25:04 don't know. It's really interesting. Medical science comes up with all these terms that are tongue twisters. How do they do that? You're 100% correct. Oh, it's a fun world. What's on the horizon, what kinds of things are coming that will kind of either enhance what they do or other sorts of medications? Yeah,   Kari Luther Rosbeck ** 25:28 thanks for asking that. So I think for us, in 2019 we put together a really aggressive research, research business plan, and our goal with this was to ultimately the vision change the course of TSC, and so we have a research platform that really helps accelerate drug development. So we fund research grants or young investigators to keep them interested in the field and to generate new ideas. We have a pre clinical consortium where we work with a contract research organization. We've licensed different mouse models that can try drugs for both epilepsy and tumor growth and behaviors, and so that is really built a pipeline of new potential therapies for TSC we also have this clinical research consortium that we work with. We have 74 TSC clinics across the country, of which 17 are centers of excellence, and we're working with our TSC clinics and centers of excellence to when drugs come out of the pre clinical or when companies come to us and they want to institute clinical trials, we will work with them to be in touch with our clinics, to educate our community about what clinical trials are out there, so they know what questions to ask or how to appropriately weigh risk benefit, so that's a really important part of our platform. We also, I mentioned earlier, a natural history database to help us understand how TSC progresses through a lifetime, but also a bio sample repository, so we'll understand why TSC is so different person to person. So with all of those tools working together, what we want to do is ultimately determine how to predict an individual's risk for the many manifestations of TSC so if we knew who was at risk, say, for epilepsy, and we could intervene to delay or prevent epilepsy. Could we do the same with kidney tumors? So that's what I mean about predicting and prevention. We would like to develop biomarkers to help accelerate outcome measures and clinical trials. We would love to have an intervention early on. Remember, I said that we helped start the first preventative clinical trial for epilepsy. You need an intervention to get on the newborn screening panel. If we could be on the newborn screening panel and identify babies early, that is the greatest way to change the course of the disease. Of course, we obviously want to test more compounds in our pre clinical consortium to make sure that we are building that pipeline for new and better drugs in the future, and we definitely want to develop patient reported outcomes. So how does this disease impact quality of life for individuals and families living with it, so that we'll know in the future, if there are different potential treatments, does it impact or improve their quality of life? And the FDA looks at patient reported outcomes quite seriously, so we want to build that for future clinical trials and clinical studies. Finally, one of the biggest unmet needs in TSC is what we call TSC associated neuropsychiatric disorders, or taint This is an umbrella term for brain dysfunction that includes everything from sleep problems to depression, anxiety, aggressive behavior, executive functioning, how people learn. So it is definitely an umbrella term, and almost everybody is impacted by tanned in some way that are living with TSC. So we want to better understand who might be at risk for which parts of tan so that we can intervene and improve quality of life.   Michael Hingson ** 29:55 Something that comes to mind we hear people talking. Think a fair amount today about gene therapy and how all of that might work to cure various diseases and so on. Is there room for that in Tse, since especially it's caused by two specific genes?   Kari Luther Rosbeck ** 30:14 Great question. We actually are working with some gene therapy companies in our pre clinical consortium looking to see if we can intervene that way.   Michael Hingson ** 30:26 It's a few years off, yeah, I can imagine, but it would be an interest if, if it truly can be done, since you're clearly able to tell that there are specific genes that are that are causing this. It's an interesting concept, given the state of science today, to think about whether that could lead to, even if it's not immediate, but later, cures for TSC and other such things, and   Kari Luther Rosbeck ** 30:57 we might start with organ specific gene therapy. For instance, if we had gene therapy early on in the brain, again, thinking about preventing seizures from ever developing, if we were able to implement gene therapy in the kidneys so or lungs so women never develop lamb, that would be a huge breakthrough. Yeah. So thinking about how that might work and how that could impact our community is tremendous,   Michael Hingson ** 31:28 I would think so. And I would think if they are able to do some work in that regard, it would be very revolutionary. And obviously, the more we learn about gene therapy overall, the more it will help with what medical science can do for TSC as well. That's right. So what does the Alliance do for families and individuals? What kinds of specific things do you all do?   Kari Luther Rosbeck ** 31:57 Yeah, we have   32:00 developed 14   Kari Luther Rosbeck ** 32:01 community regions across the country where we work with our volunteers. So they'll in their regions, host community educational meetings, walks, where they bring the community together, which is hugely important offer peer to peer support. So that is on a regional level. On our team, we have support navigators, so people that are available to take calls, emails, texts to really help when people either receive a new diagnosis, will spend a lot of time making sure they get to the right clinics, resources, support systems, or when a new manifestation arises, or if people are having some access to medication or access to care issues, we have a TSC navigator so that is a proactive online tool that people can log into and that will really take them through the journey in a way they want to gain information. So it's really written in in small bites, so that if people want more information, they can dive deeper. That's hugely important for individuals impacted. We have regular webinars, regional conferences, and every four years we hold a World Conference. Well, we will bring in experts from all over the world to cover the many manifestations of TSC so people are informed to make the best decisions for them and their families. They'll also talk about new clinical trials or new research on the horizon, or they're talk about social service tools that are really important for living or guardianship or financial planning, so those things that aren't just medical, but really impact people's lives.   Michael Hingson ** 33:57 So today, what, what do you think? Or how would you describe, sort of the social attitude toward TSC and people with TSC, or is it, is it more manifested in Well, this guy has seizures and so on, so TSC doesn't directly tend to be the thing that society views.   Kari Luther Rosbeck ** 34:22 That's a great question. And because TSC is so variable, I'm going to say to you, it's different person to person. One of the things we did a few years ago was create these little business cards that described what TSC was. So if somebody's out at a restaurant, they might hand it to their waiter or waitress to say, We want you to know that our for instance, our child has TSC and so you understand what you might see as you wait on us. For example, I still think that for those that are more severely in. Acted. I talked about tanned and some folks with more severe behaviors. You know, our society, it's attitude, right? You talked about that in your presentation of diversity to inclusion, we need to be much more understanding when a family is trying to handle a seizure or or behaviors and not pass judgment on that family, let the family handle that situation. So I would just say it's individual to individual, but one of the most amazing experiences, as is at our world conferences, where everybody can just be. And everybody understands that TSC is variable. And you might have a child over here with a seizure dog. You might have an adult group in one corner talking and dancing, but everybody comes together, yeah,   Michael Hingson ** 35:58 yeah. And that's really important to do, and that's you raise a really good point. Obviously, dogs are learning to be better at seizure detection. And I was going to ask about that, because I assume that that certainly can play into helping people who have seizures, who have TSC.   Kari Luther Rosbeck ** 36:18 That is absolutely correct earlier. You asked about what it was like early on, we didn't have a lot of seizure dogs at our early conferences. That's something that really has been happening after, say, 2010 we've definitely seen a lot more seizure dogs be trained and really be helpful to families.   Michael Hingson ** 36:39 Yeah, well, and we have come so far in terms of training dogs to be able to detect seizures and detect so many things. One of my favorite stories, and it's not a seizure detection as such, but one of my favorite stories, is about a Portuguese water dog who was a show dog, but he or she, rather, was also trained to do cancer detection. And the owner, who was very competitive in doing show dog type things, as well as had started a company or a facility to deal with cancer detection, took his dog to the show, to a dog show. And every time the dog got near this one judge, it just laid down. It would not perform, it would not work. And so needless to say, this national champion didn't do very well at that show. And the guy couldn't figure out why. And he got home, and he suddenly realized, oh my gosh, I had taught the dog to lay down whenever it detected cancer, because you don't want to do something dramatic, right? And so he called the woman who was the judge, and he said, Do you have cancer? And she says, No, I don't have anything like that. Then he said, Well, you might go check that out, because and he told her, this was like a Monday when he called her, and Friday she called him back, and she said, I took your advice. And it turns out I have early stage breast cancer. We caught it in time, and it's all because of your dog.   Kari Luther Rosbeck ** 38:04 Oh my gosh, Michael, what an amazing story   Michael Hingson ** 38:10 it is. You know, we we really underestimate our dogs. I know that the first diabetic dog was a dog who who kind of learned it on his own. His person had occasional insulin reactions, and the dog became agitated. And finally, the guy realized, oh my gosh, this dog knows what I'm going to have an insulin reaction. And that led to dogs for diabetics, which is another, of course, sort of same thing that the dogs really can learn to do so many things today.   Kari Luther Rosbeck ** 38:44 Yes, yes, they can.   Michael Hingson ** 38:48 So there's always room for dogs. So we talked, I think, in sort of terms, about your the the whole research platform that you all have developed tell us more about the research platform and what it is and where it's going.   Kari Luther Rosbeck ** 39:06 Well, I definitely talked about all of the tools within our research platform. I think we're certainly taking a deeper dive into all of the tools that that we've developed, when we think about, for instance, our bio sample repository, one of the things we're doing right now is whole genome sequencing. Why? Because we're hoping with whole genome sequencing, we'll understand if there are modifier genes. Are there other things at work that makes some people more severe than other others, and then ultimately, what we'd love to learn is what medications might work best on each individual or personalized medicine, so often in TSC with seizure medications, people end up on a cocktail. We would rather avoid that, right? Wouldn't it be nice to get the medication right the first time? That's really what we are hoping for with our clinical research consortium. Right now, we're doing a couple of quality improvement studies, so one of them is around suit up or sudden, unexpected death from epilepsy, and really understanding the conversations that happen between a physician and a patient or a caregiver, and why aren't those conversations happening in TSC or when are they happening? Because we want to create change so that parents know the risks, or individuals understand the risks, and can they change their behavior to mitigate some of those risks? The other thing that we are doing is we started a reproductive perinatal Health Initiative. This came out of our 2002 world conference because we heard from a bunch of adults that this was a gap for TSC. So TSC is variable. We have some independent adults that may want to start a family someday, but we have no no consensus guide guidance, to guide them in making those decisions. So we put together a group of experts in maternal fetal health, pulmonary nephrology, imaging genetics, to come together to first talk about what are risk stratifications, both for women that are may experiences complications in pregnancy. What are those? What's a risk stratification for each individual? Also, how do we handle perinatal health? How do we care for fetuses of women with TSC, or fetuses where they have been diagnosed with TSC, and what are those recommendations and steps? So that's a real focus for us at our organization, really filling the gaps where those exist. So that's a couple of the things that that I would mention.   Michael Hingson ** 42:16 An interesting question that comes to mind, do you see prejudices or misconceptions that cause difficulties within medical science. And I ask that because I know from a blindness standpoint, so often, when a person goes into an ophthalmologist because they're having eye problems, they go in and the doctor will say, eventually after diagnosis, well, you have retinitis pigmentosa, you're going to go blind. There's nothing I can do, and literally, just walk out of the room without ever dealing with the fact that this person can still be a very normal person. Do you see any of that kind of stuff in the world of TSC so   Kari Luther Rosbeck ** 42:56 early on, less today, but we still hear about it when people are handed the diagnosis of TSC, they it could be very cold. Physicians would say, your child will never walk, they'll never talk, they'll never live a normal life. That's horrible, like you're taking away that hope. And that may not be the case for each individual with TSC, I think some of our families, when their infants begin to have a devastating type of seizure called infantile spasms that can look just like a head nod, sometimes they are misconstrued for indigestion or startle reflex, and They try to get care for their baby, they're told that they're just being paranoid and crazy. It's nothing, but the it's up to the parents right to continue to advocate, because they know something is not right and that that is the right course of action. And then for adults, I think sometimes our adults living with TSC really struggle with adequate care. We've done a really good job of pediatric care specifically for TSC, but as a country, we could do a lot more for those with developmental disabilities, including TSC and providing adequate transition from adult care, these are the places that I see prejudice or roadblocks put up for our families.   Michael Hingson ** 44:33 How do you teach or what do you do to teach parents and adults, especially about being stronger advocates.   Kari Luther Rosbeck ** 44:43 Well, first of all, we tell them to trust their instincts and trust their voice and to not give up if you're hitting a roadblock. One place call us. Maybe there are other other clinical care that we can provide for you. Yeah. If you're having an issue at work, it's really important that you get the right support to advocate for yourself, but to never, ever give up, ever give up.   Michael Hingson ** 45:11 Yeah, that's really, of course, the important part, because ultimately, and I think it's true for most all of us, we know ourselves better than anyone else. And as parents, we know our children better than anyone else, and certainly should never give up and work very hard to be strong advocates to support what their needs are and support them to grow and advance.   Kari Luther Rosbeck ** 45:36 That's exactly correct,   Michael Hingson ** 45:41 and it needs to happen a whole lot more, because all too often, I can imagine hearing people say, well, it's nothing, it's just your it's your imagination. Well, no, it's not, you know, but we see way too much of that kind of thing happening in the world. So it's great that that you're able to do so much. What about in the in the professional world, or in just dealing with people and their lives? What? What kind of things are you able to do to, let's say, help support somebody who wants to go out and get a job?   Kari Luther Rosbeck ** 46:21 Sure? We point them to local resources that might be an expert in that. We also have navigation guides that might help them, that are a supplemental resource to our TSC navigator. We have adult topic calls and adult open forums so that they might also get guidance and advice from their peers that have walked that journey. So those are some of the resources that we will help people who want to get a job   Michael Hingson ** 46:55 do Centers for Independent Living help.   Kari Luther Rosbeck ** 47:00 Are you familiar with those? No, I'm not familiar. Sorry, I'm not familiar. So the   Michael Hingson ** 47:04 CIL system is a system of independent living centers. It really started, I don't know, but I think in Berkeley, it's centers that teach and advocate for the whole concept of being able to live independently, and deals a lot with physical disabilities, and I'm not sure how much the developmental disability world interacts in the CIL it may be a lot more of a physical thing than anything else.   Kari Luther Rosbeck ** 47:32 Well, always great to have new resources that we can share with our community. It's worth   Michael Hingson ** 47:38 exploring Absolutely, because it could very well lead to something that would be helpful, not sure, but it's always worth exploring. The arc is   Kari Luther Rosbeck ** 47:47 another organization I was gonna ask about that frequently. Yes, we've, we've had a partnership with the arc in the past. Many of our community regions obviously work with local arc chapters. It is a partnership that we truly value, and they have a ton of resources that are available for individuals, seeking jobs, seeking Independent Living, seeking so or housing for families. So we don't need to replicate what somebody is already doing. Well, we will partner with that organization,   Michael Hingson ** 48:25 and that makes sense. There's no sense in replicating. It's all about collaborating, which makes a lot more sense to do. Anyway,   Kari Luther Rosbeck ** 48:33 exactly we agree.   Michael Hingson ** 48:36 Well, so what are so, what are your your sort of long term goals from here? Oh,   Kari Luther Rosbeck ** 48:45 long term goals from here? Well, we want to continue to improve quality of life for everyone. We want to make sure that there is adequate transition between childhood and adult in terms of medical care, independent living, or housing or schooling, or whatever that transition may employ, we really want to make sure that we continue the pipeline of new treatments. We want to drive towards a cure. We want to support and empower every family living with TSC. One of the things that we've really been able to do because of advocacy, is to grow the TSC research program at the Department of Defense. So this is a congressionally directed medical research program. There's been an appropriation for TSC since fiscal year, 2002 and cumulatively, 221 million has been appropriated for TSC research. We want to continue to grow that. But on a state level, we've also had some success in growing state funding for. TST clinics in particular states, and for TSC research at those institutes. So over 5.7 5 million have been advocated, have been appropriated from the states of Maryland and Missouri and Michigan and Alabama. So very excited about continuing to grow that that program, as I mentioned, I think getting on the newborn screening panel would be a game changer for TSC, complete game changer. And we want to continue to grow our advocates and grow those that are available as leaders in their communities to offer support to others.   Michael Hingson ** 50:39 So the funding comes through the Department of Defense. Why is that?   Kari Luther Rosbeck ** 50:44 It is a program that is high risk, high reward. You have to have some military relevance. So so for TSC, obviously, our connection to epilepsy and our mass models that are used for developing epilepsy medications, those mass models can also be used to look at traumatic brain injury. So that's a connection. It's high risk, high reward. So understanding the underlying biology of TSC and finding that genetic pathway that I mentioned was one of the hallmark achievements early on of this program. So it's, it's, it is so amazing. The early gene therapy work for TSC started at the TSC research program at the Department of Defense.   Michael Hingson ** 51:33 And I gather you're probably getting a lot of really good support from DOD. So   Kari Luther Rosbeck ** 51:38 it doesn't come to the TSC Alliance, we advocate to make that funding available to researchers around the country. So we think of that as part of our mission for driving research. But we don't see a dime of that. Those dollars, they all go through Fort Detrick and through the Department of the Army, right? The other cool thing, though, Michael is we nominate consumer reviewers, so people that help advocate for these funds also sometimes get a seat at the table to say what research would be meaningful for their lives as a consumer. And that is a really cool, unique thing that happens.   Michael Hingson ** 52:21 Yeah, well, and I was asking about support, I was thinking more of their they're perfectly willing and pleased to be a part of this, and are really open to helping and really contributing to the research, because I would think it would help all the way around 100%   Kari Luther Rosbeck ** 52:40 and the one thing is the TSC Alliance, the DOD and NIH. We all work together so that we're not duplicative. But we have, there was a research strategic plan that was developed out of a workshop at NIH that we all follow as kind of our guiding principle. We all do different things, and we all complement each other. So out of that NIH plan, for instance, a bio sample repository and preclinical consortium was recommended, and recommended that the TSC alliance is the patient advocacy group, be the one that started that and continues to make sure that those resources continue. That's just an example. Obviously, DOD does high risk, high reward. And NIH, you know, the prevent trial that I mentioned, the first preventative trial for epilepsy in United States, was funded by the National Institute of Neurological Disorders and Stroke. We helped educate the community so that people would want to participate.   Michael Hingson ** 53:46 Well, it's, I think, important and relevant to ask, how can people get involved? What can the rest of us all do?   Kari Luther Rosbeck ** 53:54 Oh my gosh, I'm so glad you asked. Well, please go to TSC alliance.org, learn more about the organization. Become a volunteer. Help us. Help us with our walks, help us with our conferences. You can certainly get involved. If you're an individual with TSC and you want to get connected through social media, you can go to Facebook, Instagram, LinkedIn, YouTube, even Tiktok at the SC Alliance, we have very active discussion groups Michael that offer peer to peer support. 24/7 especially on Facebook, it is a private group, and those group of individuals and families have been so supportive for anyone walking this journey, you can call us at 1-800-225-6872, if you need support, you can ask for a support navigator. If you're interested in helping us with fundraising or making a donation, you can ask for our development department. If you want to volunteer, ask for. Community programs, we want all takers, and we're always also happy to talk with any organization, any nonprofit, that's wanting to pull together their programs, seek advice or work as a partner,   Michael Hingson ** 55:15 and what's the phone number? Again? 1-800-225-6872,   Michael Hingson ** 55:24 and the website is TSC   Kari Luther Rosbeck ** 55:26 alliance.org,   Michael Hingson ** 55:29 cool. Well, I've asked lots of questions. Have I left anything out? Any other things that you think we ought to cover? I   Kari Luther Rosbeck ** 55:37 think you did a great job. I would just say if anybody wants to join us at our 50th Anniversary Gala, we'd love to have you. TSD alliance.org, backslash 50 Gala. We will be celebrating october 25 at ciprianis in New York City, and we'd love to have you with us. Ooh, that sounds like it'd be fun. I know you gotta get your family to bring you this time. Well, yeah,   Michael Hingson ** 56:07 if they're going to come, they should, should take me. I'm trying to think, I don't know whether I'll be anywhere near there at the time, but my schedule changes all the time, so it's sort of like everything else you never know. But I will keep that in mind, because it would be fun to come and get to meet you in person. I would love that. Well, I want to thank you for being here with us. This has been, needless to say, very educational and very enjoyable. And of course, as you know, I have the personal stake of a great nephew, but just being able to talk about it, to hear the progress that's being made as, I think, really crucial and really important to be able to let people be aware of and I hope that people who do hear this will get involved, will at least learn more about it. Have you written any books or anything? I have   Kari Luther Rosbeck ** 56:57 not written any books. Oh, we got to get you to work. That's right, you're an inspiration.   Michael Hingson ** 57:04 Well, something to work on. You should? You should write a book about it all. That'd be a new project. It's not that you don't have enough to do, though. That's   Kari Luther Rosbeck ** 57:13 right. Michael, I'm too busy taking care of our community right now, but when I retire, that might be something I think about. Well, there   Michael Hingson ** 57:21 you go. Well, I want to thank you again for being here. This has been, I will say, enjoyable, but it's been most educational. I've learned a lot, and I appreciate your time, and I hope that, as I said, everyone else has as well. So I want to thank you for being here, and anytime in the future you want to come back and talk some more about what's going on and tell us about other new, revolutionary changes and so on. You are always welcome.   Kari Luther Rosbeck ** 57:46 Thank you. Michael, I'd love to come back. Well, thank   Michael Hingson ** 57:50 you again, and let's do it anytime you'd like, Okay, you got it.   **Michael Hingson ** 58:01 You have been listening to the Unstoppable Mindset podcast. Thanks for dropping by. I hope that you'll join us again next week, and in future weeks for upcoming episodes. To subscribe to our podcast and to learn about upcoming episodes, please visit www dot Michael hingson.com slash podcast. Michael Hingson is spelled m i c h a e l h i n g s o n. While you're on the site., please use the form there to recommend people who we ought to interview in upcoming editions of the show. And also, we ask you and urge you to invite your friends to join us in the future. If you know of any one or any organization needing a speaker for an event, please email me at speaker at Michael hingson.com. I appreciate it very much. To learn more about the concept of blinded by fear, please visit www dot Michael hingson.com forward slash blinded by fear and while you're there, feel free to pick up a copy of my free eBook entitled blinded by fear. The unstoppable mindset podcast is provided by access cast an initiative of accessiBe and is sponsored by accessiBe. Please visit www.accessibe.com . AccessiBe is spelled a c c e s s i b e. There you can learn all about how you can make your website inclusive for all persons with disabilities and how you can help make the internet fully inclusive by 2025. Thanks again for Listening. Please come back and visit us again next week.

Clair shares her journey from a struggling student to a scientist specializing in longevity and the carnivore diet. She discusses her academic background, her research on Alzheimer's disease, and the importance of autophagy and mTOR in longevity. Clair also reflects on her transition from veganism to a carnivore diet, highlighting the significant improvements in her mental health and overall well-being. The discussion touches on the role of AI in biotech, the development of therapies for age-related diseases, and the impact of diet on female hormones. Clair emphasizes the importance of community and spirituality in enhancing mitochondrial health and concludes with a call to action for more people to adopt the carnivore lifestyle. Chapters 00:00 Introduction to Claire's Journey 03:09 Exploring Alzheimer's Disease and Environmental Triggers 06:05 Understanding Autophagy and mTOR0 9:12 Transition from Veganism to Carnivore Diet 11:57 The Impact of Diet on Mental Health 15:03 The Role of AI in Longevity Research 18:11 Developing Therapies for Alzheimer's Disease 21:10 Female Hormones and the Carnivore Diet 24:04 Rejuvenation Technologies in Longevity 26:49 Community, Spirituality, and Mitochondrial Health 29:46 Conclusion and Future Directions

What changes do aging Females need to make to stimulate MPS? As women age and transition into perimenopause and postmenopause, several physiological changes, including declining estrogen levels, impact muscle health and the effectiveness of dietary protein in stimulating muscle protein synthesis (MPS). Here's an explanation based on insights from experts like Dr. Donald Layman and others: Why 30 Grams of Protein May Not Be Enough Declining Estrogen Impacts Muscle Metabolism: Estrogen plays a crucial role in maintaining muscle health by promoting MPS and reducing muscle breakdown. Lower estrogen levels during peri- and postmenopause reduce the body's sensitivity to dietary protein, making it harder to maintain and build muscle. Anabolic Resistance: With age, muscles become less responsive to protein intake, a phenomenon called anabolic resistance. This resistance means that older adults, particularly women with lower estrogen levels, require more dietary protein to achieve the same MPS stimulation as younger individuals. Leucine Threshold in Aging: Leucine, an essential amino acid, is the key trigger for activating the mTOR pathway and initiating MPS. While the leucine threshold for younger individuals may be around 2.5 grams per meal (found in ~30 grams of high-quality protein), this threshold increases in older adults. For peri- and postmenopausal women, it may rise to 3–4 grams of leucine per meal. Protein Needs for MPS: To meet this higher leucine threshold, peri- and postmenopausal women may require 40–50 grams of high-quality protein per meal, depending on the protein source. Animal-based proteins like whey, eggs, and lean meats are rich in leucine and more effective at stimulating MPS compared to plant-based proteins. Practical Adjustments for Aging Women Increase Protein Intake Per Meal: Shift from the general recommendation of 30 grams of protein per meal to 40–50 grams to ensure sufficient leucine and overcome anabolic resistance. Choose Leucine-Rich Foods: Incorporate foods like whey protein (1 scoop contains ~2.5–3 grams leucine), chicken breast, fish, eggs, or lean beef. Spread Protein Intake Across Meals: Aim for even protein distribution throughout the day rather than consuming most protein in one meal to maximize MPS stimulation multiple times. Combine Resistance Training: Resistance training synergistically enhances MPS, counteracting age-related muscle loss and increasing the effectiveness of dietary protein. Supplement if Necessary: Consider leucine or essential amino acid (EAA) supplements to meet the required threshold, especially in meals that may fall short of the necessary leucine content. Key Takeaway Peri- and postmenopausal women need to adjust their protein intake to counteract anabolic resistance and the loss of estrogen's supportive effects on muscle health. Consuming 40–50 grams of high-quality protein per meal with a leucine content of at least 3–4 grams is essential to optimize MPS, maintain muscle mass, and support healthy aging. Read more  https://debbiepotts.net/tips-to-improve-muscle-health-as-we-age/ https://debbiepotts.net/what-is-mps-and-why-does-it-matter-for-the-aging-athlete/    

In this episode of the Get Lean, Eat Clean podcast, I delve into the critical pathways of mTOR and AMPK, explaining their roles in muscle growth, energy management, and overall health.I emphasize the importance of balancing these pathways for optimal performance and provide practical tips for integrating them into fitness routines.The discussion highlights how understanding these molecular pathways can empower individuals to achieve their health and wellness goals effectively.Click the link below to get started!https://calendly.com/bdgryn/15minIf you love the Get Lean Eat Clean Podcast, we'd love for you to subscribe, rate, and give a review on Apple Podcasts and Spotify! Until next time!Links:Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssVFifth (5th) Element Mineral Rich Living Sea Blend:This is the World's most pure, best tasting and broadest spectrum unrefined, solar dehydrated, hand harvested Sea Salt!This artisan salt is exactly suited for hydrating the body's cells from head to toe. Just melt a small amount into the water you drink and enjoy a great tasting elixir that supplies your body the minerals it is craving.This supports a very healthy cardiovascular system that improves daily the longer you consume it in your water.https://tracking.activationproducts.com/JRD6SLRT/2H6QR9N/Upgraded Formulas hair mineral test (Coupon Code: GETLEAN10) :https://www.upgradedformulas.com/pages/kit?rfsn=6677062.f87541&utm_source=refersion&utm_medium=affiliate&utm_campaign=6677062.f87541X3Bar: Variable Resistance Technology allows for a full body workout inonly 10 minutes! Use discount code "Save50" for $50 off your purchase!https://www.anrdoezrs.net/click-100286468-13650338| Listen to the Get Lean Eat Clean Podcast |►Apple Podcasts | https://podcasts.apple.com/us/podcast/get-lean-eat-clean/id1540391210►Spotify | https://open.spotify.com/show/0QmJzYZsdV6tUNbDxaPJjS| Connect with Brian |►Website | https://www.briangryn.com►Instagram | https://www.instagram.com/bdgryn►Facebook | https://www.facebook.com/getleanandeatclean►Twitter | https://twitter.com/grynnerwinner

Subscribe to our channel: https://www.youtube.com/@optispan In this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of personalized medicine in aging research, emphasizing the need for careful interpretation of scientific data. 00:00:00 - Should Matt be skeptical of the 40% life extension figure for caloric restriction? 00:06:43 - Can calorie restriction be combined with other interventions like Rapamycin or Senolytics? 00:11:30 - Does metformin or berberine have significant effects on longevity? 00:14:51 - Is pea protein powder a good dietary choice for a complete protein? 00:17:33 - What are the best ways to increase VO2 max? 00:20:12 - Longevity Fads? 00:22:45 - How does cold exposure affect inflammation? 00:26:05 - How does NAD+ supplementation compare to NMN for longevity? 00:29:11 - What role does sleep quality play in overall lifespan? 00:32:00 - Can mindfulness or meditation improve biomarkers related to aging? 00:35:22 - Is there evidence that probiotics can extend lifespan? 00:38:45 - How does alcohol consumption affect aging and longevity? 00:41:10 - What are the best supplements for improving cognitive health with age? 00:45:00 - Are there specific dietary patterns proven to slow biological aging? 00:48:25 - How effective is Rapamycin when started later in life? 00:52:10 - Can exercise offset the negative effects of a poor diet? 00:55:34 - Is there a link between gut health and lifespan? 00:58:20 - What are the biggest misconceptions about anti-aging interventions? 01:06:33 - Do you track fiber intake? 01:07:45 - What's the common misconception about mTOR? 01:09:33 - Are there ongoing studies comparing rapamycin to other mTOR inhibitors in terms of safety and effect? 01:11:48 - Favorite band? 01:11:52 - How can a non-scientifically trained person tell good science from bad? Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/

In this fascinating episode of Grow or Die, I sit down with Dr. Chris Rhodes, a PhD researcher specializing in fasting, metabolic health, and groundbreaking supplement science. We explore the untapped power of fasting and its profound effects on metabolic health, gut health, and cognitive performance. Dr. Rhodes shares key insights from his clinical research and personal experiences with multi-day fasting, breaking down the differences between intermittent fasting and extended fasting for true metabolic reset. We also introduce Mimeo, a revolutionary product designed to mimic the metabolic benefits of fasting without the need to abstain from food. This conversation offers a deep dive into fasting science, gut microbiome health, and how supplements like Mimeo can support optimal health.    Timestamps: - [00:00:00] - Justin introduces the episode, previews the topics, and welcomes Dr. Chris Rhodes. - [00:02:06] - Background on Dr. Rhodes' academic career and experience with fasting research. - [00:03:06] - Discussion on fasting for gut health, gut motility, and microbiome reset. - [00:05:18] - Dr. Rhodes explains why fasting for more than 24-36 hours is required for microbiome reset. - [00:08:09] - Dr. Rhodes shares his personal journey and what sparked his passion for fasting research. - [00:11:30] - Dr. Rhodes breaks down how fasting influences metabolic health, chronic inflammation, and energy prioritization. - [00:16:48] - ntroduction to PAOEA and spermine, two critical compounds related to longevity and health. - [00:19:28] - Discussion on mTOR's role in longevity, anti-aging, and muscle protein synthesis. - [00:22:32] - Justin and Dr. Rhodes discuss lean body mass, longevity, and maintaining health as one ages. - [00:29:22] - Identifying symptoms of chronic low energy, mental fatigue, and the role of fasting and supplements. - [00:34:32] - Dr. Rhodes shares insights on the pain relief benefits of palmitoylethanolamide (PEA) and its sourcing challenges. - [00:40:47] - The complexities of fasting for women, differences in hormonal response, and the challenges posed by diet culture. - [00:45:38] - Discussion on the reliability of nutritional science and how conflicting studies create confusion. - [00:53:09] - Dr. Rhodes reflects on his personal experience with a 60-hour fast and the empowerment it provided. - [01:01:13] - Justin wraps up the conversation and Dr. Rhodes shares how listeners can support Mimeo and follow him on social media.   Links & Resources: Follow Dr. Chris Rhodes On TikTok: @thatnutritiondr Check Out Mimio: https://mimiohealth.com/products/mimio-biomimetic-cell-care Follow Me On Instagram: @jmihaly_ Follow "Grow or Die" On Instagram: @growordiepodcast Work With Me: https://www.togethermorefit.com/founder Join Substack For More Exclusive Content: https://justinmihaly.substack.com/ Sign Up For The Together More Elite Mentorship: https://togethermorefit.com/elitepurchase

The molecule mTOR could be the key to living a vibrant and long life. Dive into an eye-opening conversation about mTOR with an expert who has reversed chronic disease and dedicated his life to helping others do the same. This signaling molecule could be the game-changer you've been looking for regarding healthy aging and longevity. In this episode, Dr. Robert Lufkin, a physician and medical school professor at UCLA and USC, dives deep into the role of mTOR in aging, chronic diseases, and longevity. He sheds light on the significance of mTOR as a metabolic switch that can impact cell growth, repair, and various other health outcomes. Listen now and learn how to live longer and healthier today! For show notes, visit https://fivejourneys.com/podcasts/longevity-and-mtor-what-the-science-says/  Follow us on Instagram at https://www.instagram.com/feelfreakingamazing/  Related Episodes Live Longer & Reverse Aging, with Dr. Kara Fitzgerald Unlocking Longevity: Transform Your Health with a Fasting Mimicking Diet, with Dr. Joseph Antoun Try Keto for Optimal Health, with Robert & Crystal Sikes Leverage Ketosis and Fasting to Reverse Disease, with Ben Azadi Reverse Pre-Diabetes with a Fasting-Mimicking Diet, with Dr. Joseph Antoun Age Into Your Best Self, with Dr. Deanna Minich

Alan Fredendall // #FitnessAthleteFriday // www.ptonice.com  In today's episode of the PT on ICE Daily Show, Fitness Athlete division leader Alan Fredendall the metabolic pathway mTOR, the role of the amino acid leucine in activating this pathway, and how to provide practical advice to patients & athletes to better understand how the amount, source, and timing of protein consumption can facilitate accelerate healing & performance. Take a listen to the episode or check out the full show notes on our blog at www.ptonice.com/blog If you're looking to learn from our Fitness Athlete division, check out our live physical therapy courses or our online physical therapy courses. Check out our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab.

In this solosode, you’ll get to explore some of the most powerful tools and strategies for optimizing your body and mind. First, we’ll dive deep into the benefits of plant-based protein for building muscle. If you’re wondering whether plants can pack the same punch as animal-based sources, you’re in for some surprising insights. You’ll also get to explore minimalist training techniques—perfect for maintaining strength and muscle with less time and effort, so you can stay fit without spending hours in the gym. This episode is packed with actionable tips and insights designed to help you live a truly boundless life. Get ready to upgrade your health, performance, and mindset. Let’s dive in! 05:17 - Rebranding to The Boundless Life Podcast, reflections on a 17-year podcasting journey, and insights into a $25,000 blood filtration protocol in Tijuana.11:19 - The concept of solvitur ambulando ("solved by walking"), how walking improves learning, focus, neurogenesis, and boosts memory, mood, and cognitive performance.15:06 - Benefits of physical movement while learning, the Aristotelian peripatetic school approach, and using a manual treadmill for walking while working.27:13 - A study on maintaining 95% of fitness gains by training once every two weeks, combining strength and cardio in one session, and tips for efficient workouts.32:27 - Sauna use for muscle growth, recovery, and bone density via heat shock proteins, growth hormone, and mTOR activation, with evidence-based benefits from high-heat sessions.36:41 - Advantages of "weekend warrior" workouts, plant-based vs. animal-based proteins for athletic performance, and the role of leucine in boosting muscle protein synthesis on plant-based diets.44:06 - Effective melatonin use for sleep and jet lag, issues with over-the-counter dosing inaccuracies, and selecting reliable supplement brands. Full show notes: BenGreenfieldLife.com/482 Episode Sponsors: Joovv: Get an exclusive discount on your first order of my favorite in-home light therapy devices. Just go to Joovv.com/ben and apply code BEN. ZBiotics Pre-Alcohol Probiotic: Order with the confidence of a 100% money-back guarantee and 15% off your first order at zbiotics.com/BEN15 when you use code BEN15. Beekeeper's Naturals: Beekeeper’s Naturals is offering you an exclusive offer—go to beekeepersnaturals.com/BEN or enter code BEN to get 20% off your order. C60 Power: Visit shopc60.com/ben-greenfield and use coupon code GREENFIELD15 for 15% off your first order—start taking back control over your cellular health today! LVLUP Health: Head over to lvluphealth.com/BGL for a special discount on their game-changing range of products.See omnystudio.com/listener for privacy information.

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit? Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity. They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter. What you'll learn: • Why metabolic flexibility matters more than strict diet rules • The science behind long-term ketosis and insulin's broader role in health • How common “health foods” could be doing more harm than good • The importance of nutrient-dense animal-based foods for gut and immune health • How to achieve optimal balance between fat types, mTOR, and longevity markers Resources: 2025 Biohacking Conference – https://biohackingconference.com/2025 Shop Paul Saladino's Products – https://heartandsoil.co Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/ Paul Saladino's Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow Danger Coffee – https://dangercoffee.com Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ Dave Asprey's Website – https://daveasprey.com Dave Asprey's Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey's Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave. Timestamps: • 00:00 Intro • 00:40 Paul Saladino's Evolution in Diet • 01:21 Challenges of a Strict Carnivore Diet • 03:36 Reintroducing Carbohydrates • 05:32 Debunking Common Diet Myths • 13:49 The Problem with Calorie Restriction • 18:30 The Importance of Food Quality • 24:08 The Veganism Debate • 34:15 The Benefits of Organ Meats • 37:27 Foot Surgery and Bone Density • 39:23 Mineral Deficiency and Plant-Based Diets • 40:00 The Truth About Seed Oils • 41:10 Historical Studies on Seed Oils • 47:26 Mechanisms and Effects of Seed Oils • 52:33 Nicotine and Neuroprotection • 54:12 Oleic Acid and Longevity • 01:01:44 The Benefits of Animal Fats• 01:02:32 Odd Chain Fatty Acids and Health • 01:11:07 Cheese and Dairy Considerations • 01:13:11 The Impact of Cheese on Health • 01:14:03 Protein Intake and Longevity • 01:14:54 Understanding mTOR and Its Effects • 01:17:35 Ideal Body Fat and Metabolic Health • 01:24:38 The Role of Omega Fatty Acids • 01:32:46 ApoB, Insulin Sensitivity, and Longevity • 01:43:09 Final Thoughts and Product Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Rapamycin appears to be a universal anti-aging drug, extending the lifespan of all animals tested to date; it's the only known drug to do so.

Inhibiting mTOR, the “master determinant of lifespan,” is considered the best validated aging regulator.

While I've discussed longevity and aging in multiple episodes on this platform, I thought it was time for a deep dive and explain some of the nuanced details about aging and lifespan. We'll cover the primary theory of aging, the hallmarks of aging, the physiological process of AMPK and mTOR and their relationship, and much more! Topics include:   - Simplifying the Science of Aging - What We'll Cover Today - Primary Theory of Aging - The 9 Hallmarks of Aging - Stem Cell Therapy - Explaining DNA Further - Remember CD's? - 2 Pathways to Aging - Are Sacrifices and Tradeoffs Necessary? - AMPK and mTOR Relationship - Measuring Aging - Longevity Supplements ----------  My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization  www.metabolismschool.com ----------  Subscribe to My Youtube Channel:  https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1 ----------     [Free] Metabolism School 101: The Video Series http://www.metabolismschool.com/metabolism-101     ----------     Grab a Copy of My New Book - Metabolism Made Simple     ----------   Stay Connected:     Instagram: @sammillerscience     Youtube: SamMillerScience     Facebook: The Nutrition Coaching Collaborative Community     TikTok: @sammillerscience       ---------- “This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at team@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

“Nutrition cannot be underestimated – it is the medicine we take everyday,” says Robert Lufkin, M.D.  Robert Lufkin, physician, medical school professor, and New York Times bestselling author, joins us to discuss everything from lifestyle modifications to reversing chronic diseases and how to reimagine the current healthcare system, plus:  - The obesity lie (~2:02) - The calorie model (~3:10) - The impact of ultra-processed foods (~6:47) - 3 nutritional guidelines (~11:53) - Reversing chronic diseases (~15:40) - The importance of nutrition (~22:13) - Pharmaceutical use with lifestyle modifications (~26:18) - Rapamycin and mTOR (~28:15) - When to start making changes (~35:54) - The future of longevity (~38:20) - The importance of mindset (~40:55) - Final message of hope (~41:40) Referenced in the episode:  - Connect with Robert Lufkin online (https://www.robertlufkinmd.com/) - Follow him on X, Instagram, and LinkedIn (@robertlufkinmd)  - Pick up his book, Lies I Taught In Medical School  - Read the first chapter of his book (https://www.robertlufkinmd.com/lies/) - Research on rapamycin for longevity (doi: 10.1007/s11357-020-00274-1)  - Visit shop.mindbodygreen.com/coffee20 to get 20% off your first order.  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

We're thrilled to have Anthony Castor on the show. We'll be discussing a groundbreaking compound, SLU-PP 332, which uniquely targets estrogen-related receptors to enhance energy metabolism, aid fat loss, and improve mitochondrial health. Anthony will explain the fascinating concept of mitochondrial biogenesis and how SLU-PP 332 mimics the benefits of exercise by activating nuclear receptors and promoting metabolic efficiency. Hear about his personal experience with this potent compound, the protocols he followed, and the impressive outcomes he observed in energy, mental clarity, and health biomarkers. We'll also delve into the science behind cellular mechanisms, such as the activation of AMPK and its impact on energy states, fat burning, and muscle protein synthesis. Plus, we'll highlight the importance of foundational health practices and the latest on our collaboration in developing research compounds to enhance health and performance. Stay tuned as we explore the exciting potentials of SLU-PP 332 and invite you to join our community for more insights and support. Let's get started on this journey towards resilience and optimal health! This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by @marekhealth : Performance. Longevity. Optimization.

In this episode, Dr. Jockers joins Dr. Michael Karlfeldt to explore how metabolic flexibility can reduce cancer risk and support healing. They discuss the importance of helping your body switch between burning glucose and fat for better health.   You'll hear how fasting and time-restricted eating trigger autophagy, allowing the body to repair damaged cells. Lowering insulin levels plays a key role in activating this deep healing process.   Dr. Jockers and Dr. Karlfeldt also explain how reducing insulin and growth signals like mTOR helps prevent uncontrolled cell growth. By using nutrition and fasting, they reveal how to create a healing environment that weakens cancer cells.   In This Episode:    00:00 Understanding Metabolic Inflexibility 01:25 Unclogging Your Lymphatic System 02:53 Interview Introduction with Dr. Michael Karlfeldt  04:49 The Metabolic Theory of Cancer 09:04 The Role of Fasting and Diet in Cancer Prevention 16:07 The Importance of Insulin and Eating Windows 29:55 Hydration and Mineral Balance 30:38 Adjusting Meal Frequency and Timing 31:20 Fasting Strategies for Weight Loss 31:54 Fasting and Cancer Treatment 33:17 Press Pulse Strategy for Cancer 34:23 Oxidative Therapies in Cancer Treatment 47:33 Diet Principles for Metabolic Health 50:16 Protein Intake and Muscle Synthesis 54:52 Water Filtration and Hydration Tips 58:36 Conclusion and Final Thoughts     Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!     Discover the power of Lion's Mane mushroom, now more bioavailable than ever with Purality Health's nano-absorption technology. Boost your memory, speed up your thinking, and elevate your mood effectively.   Don't miss the limited-time offer of buy one, get one free. Check it out with a six-month satisfaction guarantee at Lion's Mane Complex. Visit https://lionsmanecomplex.com/drj     “Cancer cells thrive on glucose; starve them by becoming metabolically flexible." - Dr. Michael Karlfeldt     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio     Resources: GetLymphHelp.com/jockers Visit https://lionsmanecomplex.com/drj   Connect with Dr. Karlfeldt: Website - https://www.thekarlfeldtcenter.com/   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/