Podcasts about Sinclair

Independent investigative journalism, broadcasting, trouble-making and muckraking with Brad Friedman of BradBlog.com

Et vous, saurez-vous démêler le vrai du faux ? Retrouvez tous les jours le meilleur des Grosses Têtes en podcast sur RTL.fr et l'application RTL.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Send us Fan MailToday, we're joined by Dr. Colette Sinclair to explore the powerful connection between our emotions, stress, and overall health. Dr. Sinclair explains why physical wellness alone may not be enough when emotional and mental patterns are left unaddressed. She shares how stress, nervous system dysregulation, and negative thought patterns can affect everything from immunity and hormones to cardiovascular health.She also offers practical tools for shifting your emotional state, including awareness, breathwork, and intentional state training. We had such a wonderful conversation that we ended up talking longer than usual!Make sure to visit Dr. Sinclair's website below and check out her book:Dr. Colette D. Sinclair has practiced for twenty years at the intersection of neuroscience, psychology, and contemplative science. She is the creator of Emotional Posture®, a pioneering methodology for cultivating elevated emotional states that restore nervous system balance, expand consciousness, and build sustainable inner alignment. She is the founder of Integrated Mental Wellness, a collaborative collective offering natural alternatives for mental and physical wellness. Her new book is Emotional Posture: Six Energetic States to Create and Sustain Inner Alignment (Balboa Press/Division of Hay House, 2026). Learn more at Dr. Sinclair | Emotional Posture. Follow on Instagram here Find Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This episode explores why humans are biologically built to move and what happens to the aging process when we don't. Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity. Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age. He also tackles some of the biggest questions in exercise science: Can exercise offset sitting all day? Do we compensate for calories burned during exercise? Why did humans evolve such extraordinary endurance? And could exercising with others provide benefits beyond physical fitness? From our evolutionary past to the molecular machinery inside our cells, this episode reveals why movement is so deeply embedded in human biology – and why staying active may be one of the most powerful ways to keep that biology working as we age. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

This week on Our Sinclair it's we FIRE UP the motorboat, dirt bikes, and jet ski's for RUN THE GAUNTLET! Join Amigo Aaron and THE BRENT as we try to do the impossible on LIVE TV. If you enjoy Our Sinclair content, make sure to hit LIKE

In this episode, Dr Tsen Vei Lim talks to Sinclair Carr and Dr Jürgen Rehm. Sinclair is a PhD candidate at the Harvard T.H. Chan School of Public Health in the US, and Jürgen is a Senior Scientist at the Centre for Addiction and Mental Health in Canada. The interview covers Sinclair and Jürgen's updated review of the relationship between dimensions of alcohol consumption and the burden of disease. How do we determine causality? [01:29]What is Mendelian randomisation? [02:54]How do we use genes to explore causality of alcohol consumption in later life? [04:40]The context behind this study [06:05]The headline findings from the review [09:28]How can we mitigate bias as researchers? [14:18]How Sinclair and Jürgen envisage the findings to effect current alcohol policy [17:20]The barriers to enacting an effective public health policy for alcohol [20:28]Refining the methods for next steps in this review [23:50]About Tsen Vei Lim: Tsen Vei is an academic fellow supported by the Society for the Study of Addiction, currently based at the Department of Psychiatry at the University of Cambridge. His research integrates computational modelling, experimental psychology, and neuroimaging to understand the neuropsychological basis of addictive behaviours. He holds a PhD in Psychiatry from the University of Cambridge (UK) and a BSc in Psychology from the University of Bath (UK). About Sinclair Carr: Sinclair is a PhD candidate in Population Health Sciences – Epidemiology at the Harvard T.H. Chan School of Public Health, US. His research focuses on drawing causal inferences from large observational databases, with two aims: to estimate the effects of pharmacologic and lifestyle interventions, such as alcohol use, on cardiovascular and other health outcomes; and to transport these effect estimates to target populations most relevant for clinical and policy decision-making. He hopes these efforts ultimately help improve the prevention of chronic diseases.About Jürgen Rehm: Jürgen is Senior Scientist in the Institute for Mental Health Policy Research and in the Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health (CAMH). He is Professor and was the Inaugural Chair of Addiction Policy in the Dalla Lana School of Public Health at the University of Toronto, and he also holds other professorships and positions in Canada, Germany and Spain. His work has been awarded with numerous awards and prizes, most importantly, the Jellinek Memorial Award (2003), the European Addiction Research Award (2017) and the (Inaugural) Kettil Bruun Society Award for Advancement of International Research Collaboration (2021). Original article: A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies https://doi.org/10.1111/add.70435The opinions expressed in this podcast reflect the views of the host and interviewees and do not necessarily represent the opinions or official positions of the SSA or Addiction journal.The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information.Music provided by Jack Shakespeare. Hosted on Acast. See acast.com/privacy for more information.

"Anne Severn and the Fieldings" by May Sinclair is a poignant exploration of love and loss set against the backdrop of World War I. The story follows Anne, a motherless girl adopted by the Fielding family, whose lives are irrevocably altered as the war wreaks havoc on the three brothers who love her. Sinclair's nuanced prose delves into the complexities of human relationships, revealing unambiguous sexuality that challenges societal norms and underscores the profound connections between characters. This timeless tale resonates today as it confronts themes of personal sacrifice, the impact of historical events on intimate lives, and the courage to embrace authentic emotions amidst social constraints.

Nate Lindberg and David Miller discuss Cruz Montana vs. Grayson Waller and the debut of Zilla Fatu, Zaria vs. Wren Sinclair, Dion Lennox vs. Saquon Shugars, Lizzy Rain & E.K. Prosper vs. Izzi Dame & Niko Vance, Lucien Price vs. Lexis King, Mason Rook vs. Kam Hendrix, and more.Become a supporter of this podcast: https://www.spreaker.com/podcast/pwtorch-dailycast--3276210/support.

Folks, NXT was a mess last night, and I always give you the truth, believe me. Let's get into it.We opened with what was supposed to be Shawn Spears & Lizzy Rain versus The Culling — Izzi Dame and Niko Vance. Spears made this match himself in the warehouse last week because he's still mad about getting kicked out of The Culling, and then he doesn't even show up! Since only Dame and Nico are left in that group, frankly, I think Spears dodged a bullet. Rain got dragged into it because she happened to be standing nearby when the match was made — proving once again that warehouse is the most dangerous place in wrestling to just be standing around. EK Prosper replaced Spears, the mixed tag rules made almost no sense with nobody to properly tag, and Prosper ended up winning with a shining wizard and a beautiful moonsault — a match he was never even supposed to be in. Fun action, total disaster getting there.Before that, Kali Armstrong literally ripped the mic out of Prosper's hands demanding a Women's Title shot. Kelani Jordan said she was next in line, Kendal Grey limped out from Medical carrying a contract, gave Jordan a shot at Heatwave, and then Armstrong punched Grey in the head and she and Jordan beat down poor Wren Sinclair. A total mess, folks.Dion Lennox beat Saquon Shugars lame after his goons put Shugars through the table. Zaria retained the Women's North American Title over Sinclair, but the finish got hijacked by Lennox and Shugars brawling down the ramp — why interrupt THAT match, folks? Mason Rook lost AGAIN, this time to Kam Hendrix via exposed turnbuckle. I'm getting genuinely frustrated with how they're treating Rook.Lucien Price beat Lexis King clean with a nasty one-armed powerbomb — I'm assuming a Speed Title shot is coming.And the main event — Cruz Montana vs. Grayson Waller for the NXT Title #1 Contendership — was actually GOOD, folks. Curb stomp, top rope elbow, a beautiful Spin the Block from Montana. And then ZILLA FATU showed up out of nowhere, Samoan Dropped Cruz, leveled Waller, the ref threw the whole thing out, and Fatu splashed BOTH of them from the top rope. Statement made, folks.Overall, a meh NXT — messy, disorganized, but not without some good wrestling buried in there.LIKE, SUBSCRIBE, and tell me — is Zilla Fatu your next NXT Champion?Visit our website ➡️➡️➡️ https://www.majesticproduction.com/Watch our full podcast here ➡️➡️➡️ anchor.fm/majestic-production

Greg Sinclair did not take a straight line into private lending. He went from teaching school in Ontario and the UK, to selling beer on the night shift at a local brewery, to building out the sales and marketing function for the Peterborough Petes in the OHL, to joining Magenta Capital when Covid shut down the sports world. He is now COO of one of the longest-standing MICs in Canada, a company founded out of a basement in 1994 that now manages $470 million in residential mortgages across Ontario.Ryan and Neal sit down with Greg to talk through what has kept Magenta disciplined for 32 years, why they built a $470 million book with zero commercial, zero construction, and never leaving Ontario, and what drove the decision to finally enter the GTA a year and a half ago. They also get into Greg's read on where the Canadian real estate market sits right now, why condos are likely still a couple of years from recovery, what AI actually looks like inside a private lender's operations, and why tightening bank regulation keeps sending better and better borrowers into the alt space.Plus career advice for anyone trying to break into the mortgage world, and some honest Leafs talk to close it out.Show Chapters:2:07 Meet Greg Sinclair, COO at Magenta Capital 2:47 From Teacher to Brewery to OHL Analytics 7:21 Landing the Peterborough Petes Job 10:25 How Covid Led Greg to Magenta Capital 11:09 32 Years and $470M: How Magenta Got Here 13:36 The Decision to Enter the GTA 16:57 $470M AUM on 1,000 Residential Loans 17:19 Magenta's Products and Lending Parameters 22:38 Looking Three Years Ahead: What Magenta Is Building 24:29 Market Outlook: Near the Bottom or In It? 26:20 Atlantic vs Ontario: Two Very Different Stories 30:39 AI as an Accelerant, Not a Replacement 33:40 Why Alt Lenders Keep Taking Market Share 36:16 The Biggest Risk for MICs Right Now 38:44 Career Advice for Mortgage ProfessionalsResources:Keystone Capital GroupCPLP Instagram: @cplpodcastKeystone Instagram: @keycapgroupFind Neal On:Instagram: @neal.andreinoLinkedIn: Neal AndreinoFind Ryan on:LinkedIn: Ryan MacNeilE-mail: ryan@keycap.caENROL IN THE CPL NEWSLETTER:http://eepurl.com/FIKgpXhSbH

What separates great leaders from everyone else isn't talent. It's how they perform when the pressure is on. In this episode of It's Lonely at the Top, Nancy MacKay sits down with performance psychologist Dr. Dana Sinclair, Founder of Human Performance International, to explore the mindset and emotional mastery required to lead at the highest level. Dr. Sinclair has spent her career helping CEOs, executives, surgeons, elite athletes, Olympic champions, and professional teams across the NHL, NBA, NFL, MLB, MLS, PGA, and Olympic sports perform under pressure. Together, they discuss confidence, managing emotions, overcoming self-doubt, building resilient teams, and why emotional mastery may be the greatest competitive advantage a leader can develop. Whether you're leading an organization, building a high performing team, or navigating your own leadership journey, this episode offers practical insights you can apply immediately.  Order Nancy's New Book: Drawing on two decades of experience with more than five thousand leaders, Nancy reveals how to prioritize health, strengthen relationships, reclaim time, and develop resilience. Order ‘It's Lonely at the Top: CEO Strategies for Inspiring Yourself and Your Team' today: https://bit.ly/3OcBTQH  Are you feeling lonely at the top?  Leadership can be rewarding, but it can also be isolating. Our CEO Performance Diagnostic™ is designed to help CEOs, Executives, and Business Owners identify hidden constraints affecting their decision-making, leadership effectiveness, time allocation, innovation, and growth. Take our CEO Performance Diagnostic™ quiz: https://mackayceoforums.com/ceo-leadership-diagnostic/   Join a MacKay CEO Forums⁠⁠⁠⁠⁠ Peer Group:  MacKay CEO Forums⁠⁠⁠⁠ brings results-oriented CEOs, Executives, and Business Leaders together to solve their toughest problems and maximize opportunity through peer learning and support. Learn more: https://mackayceoforums.com/members/ 

In this episode of Luvbites by Dr. Tara Podcast, Alicia Sinclair (sex educator) joins Dr. Tara to deep dive into all things sex toys. Alicia brings some of her favorite toys for him, her, and couples, and they break them down one by one. They cover how each toy works, who it's best for, and how to choose the right toys to add more pleasure and fun to your sex life. #drtara #sexeducation #relationshipadviceMeet the Le Wand Mini Micro Wand—a compact, travel-friendly massager that delivers powerful pleasure wherever you go. Use code DRTARA at checkout!Shop here:https://www.lewandmassager.com/le-wand-mini-micro-wand-rechargeable-pocket-size-massager.html?&92_294 Connect with Dr. Tara:https://luvbites.squarespace.com/Connect with our guest:@aliciasinclair

Stijn Schmitz welcomes Peter Carlin to the show. Peter Carlin is Commodity Broker, Trader, and Author. The discussion opens with the extreme volatility in global energy markets, where the Strait of Hormuz and Red Sea disruptions are creating severe logistical bottlenecks. Carlin explains that the real crisis is not crude oil supply per se, but a mismatch between the sour crude grades needed by Western refineries and the sweet crude that is more readily available. The US Strategic Petroleum Reserve is being heavily drawn down, particularly its sour component, to feed refineries and supply Europe, while refinery utilization rates in America are running unsustainably high, threatening system integrity. He notes that the situation is fluid and that any return to normal is unlikely; the geopolitical landscape has fundamentally shifted, with the US military presence in the Gulf diminished and Iran successfully exporting oil to China, settling in renminbi via alternative payment systems. The conversation shifts to gold and currencies. Carlin observes that gold's recent price action is linked to the apparent disappearance of a distressed seller in the Gulf, now that loadings have resumed. He sees the yen's weakness as a key barometer for gold, arguing that intervention cannot save the Japanese currency, and a sovereign debt crisis there would trigger contagion, driving investors toward gold and equities. He advises against chasing strength and recommends buying gold on weakness, cautioning that the public tends to do the opposite. Silver, while volatile, remains a leveraged play on fear but requires extreme caution due to professional traders dominating the market. Finally, Carlin shares the story behind his book, “A Pocketbook of Gold,” co-authored with the legendary Jim Sinclair, who famously called the 1970s gold bull market and the 2011 peak. The book, now available as a PDF, distills Sinclair's trading wisdom and serves as a survival manual for monetary turmoil. Carlin emphasizes the importance of disciplined, patient trading over speculative home runs, a lesson drawn from decades of market experience. Timestamps: 00:00:00 – Introduction 00:01:10 – Gulf Conflict and Hormuz 00:03:42 – Oil Logistics and Shipping 00:09:27 – Shale & Refining & SPR 00:14:07 – Economic Picture & Supply 00:19:20 – Geopolitical Shifts in Gulf 00:24:14 – Gold Devaluation Strategy 00:27:10 – Trading Crude Oil Markets 00:30:20 – Chinese Payment Systems 00:35:15 – Yen Intervention and Debt 00:43:40 – Debasement & Markets 00:51:12 – Silver Thesis 00:54:30 – Pocketbook of Gold Guest Links: Book: https://www.apocketbookofgold.com/ Peter D. Carlin has spent the past 20 years as a commodity broker and trader, having worked for such firms as ICAP, NatSource Tullett and Eurobrokers. He has also worked as a consultant for several multinationals in the field of energy risk management. As a journalist, Mr. Carlin has written for the Financial Times and Bloomberg and has published articles for Jane's Defence, Money Week and numerous other journals. He regularly appears on the BBC, CNN, and NBC as a commentator.

STRANGE UK - English Cryptids & Legends - Steve Stockton & Paul Sinclair of Truth Proof - Steve welcomes Paul Sinclair, veteran paranormal researcher, author and documentary filmmaker, who discusses strange goings-on in the U.K. Find Paul on his YouTube channel Truth Proof https://www.youtube.com/@paulsinclairtruth-proof , and on the web at https://www.truthproof.uk/Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.        __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and longevity scientist – details how to exercise for a longer, healthier life. Drawing on the latest research, Dr. Sinclair explains why exercising for longevity isn't the same as training for peak athletic performance – including how much exercise you really need, which types matter most as you age, and whether more exercise is always better. He also breaks down the key fitness metrics for longevity – including VO2 max, grip strength, resting heart rate, and heart rate variability (HRV) – and why cardiorespiratory fitness may predict mortality more strongly than smoking, diabetes, or hypertension. Lastly, Dr. Sinclair tackles some of the most common questions about exercise science: What's the best time of day to work out? Should you drink coffee beforehand? Should men and women train differently? How should exercise change as you age? Whether you're just getting started or already exercise regularly, this episode offers a practical, evidence-based guide on what to do to stay healthier for longer.     __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

Independent investigative journalism, broadcasting, trouble-making and muckraking with Brad Friedman of BradBlog.com

The inaugral Dayton Champions Baseball League All Star Game is now available on demand at no charge!

July 25, 2026-- Sandra interviews Alexandra Sinclair about her Farmstand 382 in Gilmer County. Farmstands have become a growing trend in North Georgia. She also created an interactive map of nearly 20 farmstands around Gilmer County.See omnystudio.com/listener for privacy information.

The Dadley Boyz preview tonight's NXT and discuss...NXT Underground Women's Championship match!Tag titles on the line!Wren Sinclair vs. Zaria!Jaida Parker and Thea Hail team up!Grayson Waller's PIPEBOMB FALLOUT?!ENJOY!Follow us on Twitter:@AdamWilbourn@MSidgwick@MichaelHamflett@WhatCultureWWEFor more awesome content, check out: whatculture.com/wwe Hosted on Acast. See acast.com/privacy for more information.

Welcome to Our Sinclair, a show were two big fat hairy guys look at Garfield's Big Fat Hairy Deal for the ZX Spectrum! I HATE Mondays, but I LOVE Garfield, and we'll be talking about his ZX Spectrum debut game. If you enjoy Our Sinclair content, make sure to hit LIKE

Auckland's Watercare is taking a mixed approach to funding a $15.2 billion capital investment. This includes $4.3 billion for renewals, upgrades to prevent wastewater spills, and lifting the daily flow of drinking water from Waikato River to $300 million by 2033. Watercare CEO Jamie Sinclair says separating from Auckland Council means the utility will need to explore new funding streams to get this through. "We've got to go find our own debt funding, which we've been pretty successful at, I'd have to say, over the last year or so." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Garfield is a cat after my own heart! He's lazy, he's hungry, and he's a smart aleck! I don't think there are two men on earth more suitable to review this game than Amigo Aaron and the Brent!

David and Rachel discuss the second of two electric vehicle designs that did not exactly go to plan. Script by Stephen.

What if finding more peace, resilience, and purpose doesn't require changing your entire life, but simply use a small daily practice that strengthen your spirit, especially in life's most difficult moments? Tune in for an inspiring discussion with Allen L. Sinclair on his new book Spiritual Strength for Everyday Life: Simple Practices to Transform Stress, Strengthen Your Mind, and Restore Inner Balance.Moments with Marianne Radio Show airs in the Southern California area on KMET1490AM & 98.1 FM, an ABC Talk News Radio Affiliate!  https://www.kmet1490am.comAllen L. Sinclair writes reflective nonfiction for people seeking steadiness in an unsettled world.After decades of service as a retired U.S. Army Officer, Registered Nurse, volunteer EMT and firefighter, and farmer, Allen's work is shaped by lived experience with stress, caregiving, uncertainty, and resilience. His writing does not offer quick fixes or rigid systems. Instead, it invites readers into small, grounding practices that support spiritual strength, emotional presence, and meaningful connection. Throughout this book and future books, Allen explores themes of faith, healing, service, and the quiet disciplines that help people endure and grow throughout life. His approach honors reflection over urgency, gentleness over striving, and return over perfection. When not writing, Allen continues to serve his community, care for nature, and live a life shaped by simplicity, care, and commitment to others. His work is an invitation to slow down, reconnect, and rediscover the strength that is already present.http://www.allenlsinclair.comOrder on Amazon: https://a.co/d/0jkR2OqXDiscover inspiring conversations with today's leading authors, celebrities, thought leaders, and change makers. To learn more about the Moments with Marianne Radio Show, explore guest interview opportunities, connect with Marianne, and follow her on social media, visit https://www.mariannepestana.comExplore the Moments with Marianne Book Club and find your next great read: https://www.mariannepestana.com/book-club/Listen to the Moments with Marianne Radio Show on KMET 1490AM & 98.1FM, an ABC News Radio Affiliate, weekdays at 8:06 AM PT / 11:06 AM ET and Sundays at 10:06 AM PT / 1:06 PM ET. Learn more at: https://www.kmet1490am.com/moments-with-marianne

Fredericks Goldman Jones - Juste après Tibz - On n'est pas bien là Dynamite Shakers - Cinéma Daniel Balavoine - Mon fils ma bataille BB Brunes - Éclair éclair Jenn Ayache - About Us Charlotte Cardin - Tant pis pour elle Gérald de Palmas - Il faut qu'on s'batte Tryo - La traversée Matmatah - Emma Sinsémilia - Tout le bonheur du monde Louise Attaque - J't'emmène au vent Clara Luciani - Amour toujours Serge Gainsbourg - No Comment Jean-Louis Aubert - Commun accord Indochine - Les nouveaux soleils David Hallyday - Tu ne m'as pas laissé le temps Yoa & Marine - Princesse Chaos Gamine - Voilà les anges Benjamin Biolay - Écran total Helena - Tout a changé (Rien n'a changé) Calogero - En apesanteur Louane - Conduire Jérémy Frérot - Frérot Dolly - Je n'veux pas rester sage Hervé - Monde meilleur Corson - Raise Me Up (Je respire encore) Renaud - Dès que le vent soufflera Deluxe Feat. M - Baby That's You Zazie - Peu importe Sinclair - Si c'est bon Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Title: Free IndeedSpeaker: Pastor Rob SinclairDate: 19th July 2026Location: Ballarat, Australia Summary:What does it really mean to be free? This episode traces one thread through the whole Bible: the difference between captivity and freedom, and how that freedom only ever comes from God's Spirit. It starts with Samson, tied up and surrounded by enemies who think they've finally beaten him, until the Spirit of the Lord comes on him and the ropes fall away like burnt string. But Samson's story is also a warning. Despite knowing exactly how God had set him free before, he kept walking back into danger with Delilah until he lost everything, including his sight and his freedom. From there the episode moves through Jesus in the synagogue at Nazareth declaring he's come to set captives free, through the cross where Jesus stayed bound by choice so we wouldn't have to be, and into Paul's letters about what it means to be truly free in Christ. It's a practical look at the kinds of captivity we don't always notice in our own lives, whether that's addiction, pride, or just the daily grind, and how real freedom is found. Key Points: Samson's strength came entirely from God's Spirit, not from his own power, and the same Spirit is what breaks any kind of captivity in our lives Being aware of a problem doesn't guarantee we'll avoid it. Samson had every warning he needed and still walked back into the same trap three times True freedom in Christ isn't the absence of a master. It's trading captivity to sin for a life spent serving God and others out of love Reference Scriptures: Judges 15:9-19 Judges 16:4-21 Luke 4:14-21 Matthew 27:1-2 Ephesians 3:1, 4:1-9 Psalm 68:18-19 John 8:31-36 Romans 5:21-6:23 Galatians 5:13-16 Listen to the entire Podcast Revival library by visiting https://podcastrevival.com The Revival Fellowship is a Bible-directed, Spirit-filled Church and we welcome visitors to our meetings at any of our locations worldwide. To find your nearest venue visit https://therevivalfellowship.com © 2026 The Revival Fellowship. All Rights Reserved.See omnystudio.com/listener for privacy information.

Crowley HS Football revitalized and it's roots may lie in a realtionship between it's new Head Coach and our favorite ole' ball coach

STRANGE UK - England's Cryptids & Legends - Steve Stockton & Paul Sinclair from Truth Proof -  Steve welcomes Paul Sinclair, veteran paranormal researcher, author and documentary filmmaker, who discusses strange goings-on in the U.K. Find Paul on his YouTube channel Truth Proof https://www.youtube.com/@paulsinclairtruth-proof , and on the web at https://www.truthproof.uk/Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Producer Josh updates us on how they're beating the heat in Tokyo, a stolen Sinclair dinosaur, and what ever happened to the monoliths in Utah?

Here comes the heat again. Not bad today with a high around 80°…but reaching the upper 80's tomorrow and into the 90's by Sunday & Monday. Uffdah. Today is Jean's last day on the show for awhile as she & the family are headed to Boston & Cape Cod for a summer vacation. Speaking of Summer…a bunch of people like to into Halloween-mode the day after the 4th of July. And if you're one of them, we talked about some horror movies that are set during the Summer months that you might want to watch. In the news this morning, Powerball is now available in the US and the UK, a recall on toaster ovens, a bear got stuck on a utility pole, Vance Boelter is sentenced, a verdict in the Shiloh Hendrix case, and the latest on the deadly officer-involved shooting in Madison. In sports, the Brewers start a 3-game series with the Rockies tonight, the Dodgers visited the White House yesterday to celebrate their World Series win last season, Fernando Mendoza signs his rookie contract with the Raiders, the Ravens already released Diego Pavia, and Patrick Kane is coming back to Chicago! We let you know what's on TV & streaming this weekend and what's new in theaters. Plus, some new music you may want to pick up. Also talked about a new series being produced by Peyton Manning called "NASCAR: Americana" Earlier this week, we had a story about USPS worker in #Florida who was picking up random animals while delivering mail and bringing them back to her house…and now a bunch of those animals are being reunited with their rightful owners. Also, a teenager with some serious lasso skills just recently saved a person who was drowning in the Yellowstone River. And speaking of helping people…who better than Spider Man to come to someone's rescue??? We had a new "Karen of the Day" who really doesn't like people using his driveway to turn around in. Elsewhere in sports, the Cubs aren't seeking any punishment for the fan involved in that viral slapping incident last weekend, the Norweigan Football Federation is lodging a formal complaint with FIFA in regards to President Trump's World Cup involvement, and a fan who jumped into a fountain in Kansas City to grab a home run ball gets an assist from the player who hit the dinger. Doc joined us just after 8am for today's Racing Report thanks to County Materials in Holmen & Eau Claire. And in today's edition of "Bad News with Happy Music", we had stories about a Sinclair gas station dinosaur that was recently stolen & moved to a more scenic location, a #FloridaMan who received over a kilo of cocaine in the mail, a woman in Tennessee who got arrested after she exposed herself during a traffic stop, a fight between a swimmer & a kite surfer that almost turned deadly, a search of a funeral home found a bucket filled with organs, a dead body was discovered in a donation box, and a former doctor in Washington state who hired a hitman to get his ex-wife addicted to heroin.See omnystudio.com/listener for privacy information.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                                __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life. Dr. Sinclair shares an exclusive update on ER-100, including his team's successful restoration of vision in non-human primates and the launch of the world's first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy. Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain. Whether you're interested in longevity, brain health, or protecting your eyesight, this episode provides an evidence-based look at the biology of vision and the future of regenerative medicine.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

Keiko Fujimori em comício de campanha, Peru, 2026. Foto: Renato Pajuelo/EFE. O que a vitória de Keiko Fujimori no Peru e a de Abelardo de la Espriella na Colômbia têm em comum com mais de duzentos anos de política externa americana para a região? Para Carolina Silva Pedroso, professora adjunta na Unifesp e pesquisadora vinculada ao Instituto Nacional de Ciência e Tecnologia para Estudos sobre os Estados Unidos (INCT-INEU), a resposta está na ideia da América Latina como “quintal dos Estados Unidos”. Neste episódio, produzido em parceria com o Observatório da Extrema-Direita, David Magalhães e Guilherme Casarões recebem Carolina para discutir a nova onda da direita radical na região, os mitos que cercam a Venezuela chavista, entre eles a suposta fraude sistemática nas urnas eletrônicas, e a forma como o apoio explícito de Washington tem funcionado como variável interveniente no fortalecimento dessas lideranças. No bloco de notícias, David percorre seis frentes do avanço da ultradireita global, da disputa entre Jordan Bardella e Marine Le Pen pela candidatura do Rassemblement National na França à defesa do gás russo feita por Alice Weidel, da AfD alemã, passando pela viagem transnacional da senadora australiana Pauline Hanson ao Reino Unido, pelo mainstreaming dos Democratas Suecos, pelo fracasso de um projeto de perda de nacionalidade em Portugal e pela relação entre futebol e o passado ustacha na Croácia. E ainda tem, no último bloco, dica cultural com a minissérie O Complô Contra a América, de David Simon. Aperte o play! Quer apoiar o Chutando a Escada? Acesse chutandoaescada.com.br/apoio Mande um café usando nossa chave PIX: perguntas@chutandoaescada.com.br Comentários, críticas, sugestões? Escreva pra gente em perguntas@chutandoaescada.com.br Participaram deste episódio: David Magalhães (UFU/OED), Guilherme Casarões (FIU/OED) e Carolina Silva Pedroso (Unifesp/INCT-INEU). Inserção musical no final: “The Day They Died”, de Sarah Hester Ross. Capa do episódio: Keiko Fujimori em comício de campanha, Peru, 2026. Foto: Renato Pajuelo/EFE. Escute também no Spotify, no YouTube ou Apple Podcasts. Citados no episódio ROTH, Philip. The Plot Against America. Boston: Houghton Mifflin, 2004. SIMON, David (criador). The Plot Against America [O Complô Contra a América]. HBO, 2020. Minissérie. LEWIS, Sinclair. It Can’t Happen Here [Isso Não Pode Acontecer Aqui]. Nova York: Doubleday, Doran & Company, 1935. Capítulos: 00:00 — Introdução 04:00 — A direita radical na Venezuela e a diáspora de Miami 14:00 — O “espantalho perfeito”: mitos, narcoestado e urnas eletrônicas 26:00 — O quintal dos Estados Unidos e a política de Trump para a América Latina 36:00 — Peru: a quarta tentativa de Keiko Fujimori 45:00 — Colômbia: o Uribismo 2.0 de Abelardo de la Espriella 54:00 — Boletim OED: França, Alemanha, Reino Unido, Suécia, Portugal e Croácia 1:11:00 — Dica cultural: O Complot Contra a América The post A nova onda da direita radical na América Latina appeared first on Chutando a Escada.

Lauren Livak Gilbert is the Executive Director of the Digital Shelf Institute, a community of more than 11,000 brands and retailers navigating eCommerce and the digital shelf. She leads research, education, and industry collaboration on emerging commerce trends. Lauren specializes in agentic commerce, product content, citations, measurement, and helping brands turn complex digital shifts into practical strategies that drive customer acquisition and growth. Max Sinclair is the Founder and CEO of Azoma (formerly Ecomtent), an agentic commerce platform helping brands improve visibility and performance across AI-powered shopping. He leads company strategy, growth, and enterprise partnerships while advising brands on product discovery, content, and conversion across ChatGPT, Amazon Rufus, Walmart Sparky, and Google Gemini. Max also co-hosts The New Frontier: The Agentic Commerce & Answer Engine Optimization podcast. In this episode… Agentic commerce is becoming a priority for brands, but many teams are still defining how it fits into their eCommerce strategies. Rather than replacing the digital shelf, it expands how AI systems discover, evaluate, and recommend products. How can brands turn this shift into measurable growth? Digital shelf strategist Lauren Livak Gilbert and agentic commerce entrepreneur Max Sinclair answer by organizing the challenge around five C's: completeness, context, citations, correctness, and customer acquisition. Their framework shows brands how to strengthen product data, answer detailed shopper questions, build trust through credible sources, and correct inaccurate information across AI platforms. Lauren recommends treating agentic commerce as an extension of existing digital shelf work while developing a deeper understanding of shopper needs. Max emphasizes monitoring the entire category, identifying the sources AI tools rely on, and connecting visibility efforts to conversion and incremental revenue. Together, their guidance offers a practical way to prepare internal teams, prioritize investments, and measure meaningful business impact. In this episode of The Digital Deep Dive, Aaron Conant talks with Lauren Livak Gilbert, Executive Director of the Digital Shelf Institute, and Max Sinclair, Founder and CEO of Azoma, about decoding agentic commerce through the five C's. Lauren and Max show how brands can improve data completeness, add richer context, strengthen citations, ensure correctness, and drive customer acquisition. They also discuss AI shopping behavior, brand accuracy, and practical measurement.

David and Rachel discuss the first of two electric vehicle designs that did not exactly go to plan. Script by Stephen.

The $1.66 billion mega-pipe solution to some of Auckland's water woes was officially opened today. Watercare's Central Interceptor tunnel runs for 16.2km from Point Erin in Herne Bay to the Māngere Wastewater Treatment Plant. "What it does is it creates, basically, a new backbone for our wastewater system, and will over time really reduce those overflows that are occurring into our harbours," Watercare CEO Jamie Sinclair told Heather du Plessis-Allan. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Former Honolulu police sergeant Darren Cachola is asking taxpayers to fund his legal defense as he faces a civil rights class-action lawsuit stemming from DUI arrests made without evidence. Plus, Kauai Police Department leaders faced tough questions from the north shore community over their handling of the multi-day manhunt for murder suspect William “Billy” Sinclair. Meanwhile, Honolulu may soon become home to giant pandas.See omnystudio.com/listener for privacy information.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                               __________________________________________ In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D.  – Professor of Genetics at Harvard Medical School and a pioneer in longevity research – explores how to fast effectively for health and longevity. Drawing on decades of research and the latest scientific evidence, Dr. Sinclair explains how to approach fasting effectively, what happens inside your body at the 12-, 24-, and 48+-hour marks, how to overcome common plateaus, and the key considerations for women, men, and people at different stages of life.  Whether you're new to fasting or looking to refine your approach, this episode provides a practical, evidence-based guide to using fasting to support metabolism, cellular repair, and healthy longevity.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

STRANGE Britain - England's Cryptid Legends - Steve Stockton & Paul Sinclair of Truth ProofBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.

Get the 200+ Page Optimal Living Daily Workbook (PDF) — Free. Want to turn today's episode into an actionable plan? Join the Optimal Living Weekly newsletter and I'll send you our 200-page digital workbook immediately. It's packed with the best takeaways from the show, formatted for easy reading and implementation at home. Get your free PDF workbook here: ⁠https://oldpodcast.eo.page/join⁠ Discover all of the podcasts in our network, search for specific episodes and learn more at:⁠ OLDPodcast.com⁠. Episode 3067: Seth Sinclair explores how your natural approach to conflict shapes the way you negotiate and why becoming aware of those tendencies can lead to better outcomes. By learning when to shift between competing and accommodating styles, you can avoid unnecessary stalemates, protect important relationships, and negotiate with greater confidence and intention. Read along with the original article(s) here: https://michaelmehlberg.com/blog/2016/10/24/how-to-win-more-negotiations-by-changing-your-conflict-style Quotes to ponder: "A negotiation is a type of conflict, a situation where your concerns and interests are not aligning with those of another person, and you are actively seeking a solution." "Understanding your tendencies in responding to conflict, and how you may need to adjust them, will give you an advantage as you work through a negotiation." "There is nothing inherently right or wrong about either of these modes. They both have benefits and costs depending on the situation." Episode references: Harvard Program on Negotiation: https://www.pon.harvard.edu/ Thomas-Kilmann Conflict Mode Instrument (TKI): https://kilmanndiagnostics.com/overview-thomas-kilmann-conflict-mode-instrument-tki/ Getting to Yes: Negotiating Agreement Without Giving In: https://www.amazon.com/Getting-Yes-Negotiating-Agreement-Without/dp/0143118757 Learn more about your ad choices. Visit megaphone.fm/adchoices

El doble de Luis Miguel Sí se terminó el show de Angélica ValeEmiliano Aguilar demandará a managerMariana Garza habla de serie Timbiriche Ninel no le paga al maquillistaBoda de Taylos Swift y Travis KelceAna Carla Sinclair se protege de Gabriel Soto 

In this episode, Jon and Adam are joined by instructor and 3D motion capture expert Jon Sinclair for a deep dive into what the best players actually do — and what everyday golfers should not blindly copy. Sinclair explains why many so-called fundamentals, like grip, stance, and posture, are not universal, and how great players often succeed by building around their own “superpowers.” The conversation explores how golfers create consistency through better thought processes, why trying to fix every bad shot can make things worse, and how swing changes need to evolve into playable skills on the course. They also get into wedge technique, short-game launch conditions, shaft consistency, and why better data should simplify your golf game rather than make it more confusing. Visit Jon's website to learn more about his services here: https://www.sinclairgolf.com/ Thanks to our show sponsors, For Wellness, LMNT, Ethos, and Pestie Golfers who care about their game should care about taking care of their bodies too. The Good Stuff from For Wellness is a small scoop that can be added to coffee, smoothies, or protein shakes, with ingredients like collagen for joint support, L-theanine for focus, MCTs for energy, cinnamon for antioxidants, and Himalayan salt for minerals and electrolytes. Sweet Spot listeners can get the best price on a 90-day subscription and welcome kit at ⁠⁠⁠⁠⁠⁠forwellness.com/sweetspot⁠⁠⁠⁠⁠⁠ with promo code SWEETSPOT for an extra 10% off. • As the weather gets warmer, staying properly hydrated on the golf course becomes even more important. LMNT's new Lemonade Iced Tea flavor combines electrolytes, magnesium, and potassium with no sugar or questionable sports drink ingredients, plus caffeine from black tea extract for a steadier energy boost. Because the caffeine comes from tea, it's naturally paired with L-theanine and polyphenols, which can feel smoother than the spike-and-crash effect of many energy drinks. For golfers looking for hydration and a little back-nine energy, this is a great option to try. With any purchase you're going to get a free sample pack. To claim your special offer visit ⁠⁠drinklmnt.com/sweetspot⁠ • Protect your family's financial future with life insurance through ⁠⁠⁠Ethos⁠⁠⁠. Ethos makes the process simple and 100% online—you can get a quote in seconds and apply in as little as 10 minutes, with coverage options up to $3 million and some policies starting around $30 per month. There's no medical exam required—just answer a few health questions online to get started. Learn more and get your free quote at ⁠⁠⁠https://ethos.com/SWEETSPOT • Pestie makes pest control simple by giving you a DIY kit with the pro-grade treatment, sprayer, mixing bag, gloves, and instructions you can complete in less than 10 minutes. Each plan is customized to your location, season, bugs, and climate, so you can protect your home year-round without waiting around for contractors, dealing with service windows, or signing expensive contracts. Fix your bug problem before it gets worse — go to ⁠https://pestie.com/SWEETSPOTS⁠ for 10% off your order. Learn more about your ad choices. Visit megaphone.fm/adchoices

A Note from James:I've been obsessed with anti-aging and longevity science for a long time. I've had many longevity researchers on the podcast, but this episode feels different because something we've been discussing for years has now moved into human trials.David Sinclair first came on the show in 2019, when his book Lifespan was published. He's a professor of genetics at Harvard Medical School, and that first conversation changed how I lived. I started experimenting with intermittent fasting, paid much more attention to sleep, and began researching many of the supplements and lifestyle changes he discussed.But the most important idea David talked about wasn't a supplement. It was the possibility of reversing cellular age using Yamanaka factors—genes that can reset the instructions cells use to function. At the time, nobody knew whether this could be done safely without causing cancer or making cells lose their identities.Now, a therapy based on three of those factors has entered its first human clinical trial. The initial target is age-related damage to the optic nerve, including open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy. The trial is designed primarily to evaluate safety, but researchers will also measure visual function.David explains how this technology worked in mice and nonhuman primates, why the eye was chosen as the first organ, and how the same approach might eventually be applied to the liver, lungs, joints, skin, and brain.We also cover the practical questions people always ask him: NMN, NAD, metformin, berberine, testosterone, growth hormone, diet, fasting, sleep, exercise, and what David himself has started—or stopped—taking.This is still experimental science. Nobody yet knows whether the animal results will translate into meaningful benefits for humans. But for the first time, researchers are beginning to test that question directly.About Lifespan: Dr. David Sinclair founded Lifespan to deliver clear, science-backed health insights that help people live longer, more vibrant lives.He's now building the world's largest community dedicated to extending human longevity well beyond today's limits. Join early access at lifespan.com. New episodes of Lifespan with Dr. David Sinclair -- the #1 health and wellness podcast in its first season -- are now available on YouTube, Spotify, Apple Podcasts, and Lifespan.com.Episode Description:For years, longevity researchers have looked for ways to slow the biological processes associated with aging. Dr. David Sinclair and his collaborators are now testing a more ambitious possibility: whether damaged human cells can be restored to a younger, more functional state.The experimental therapy, ER-100, uses controlled expression of three transcription factors—OCT4, SOX2, and KLF4, collectively known as OSK. These are three of the four Yamanaka factors originally used to transform adult cells into pluripotent stem cells.Turning on all four factors can erase too much of a cell's identity and has produced tumors and fatal outcomes in animal experiments. Sinclair's team found that removing one factor, c-MYC, allowed cells to regain younger patterns of gene expression without completely returning to a stem-cell state.In preclinical studies, OSK restored youthful epigenetic patterns, promoted optic-nerve regeneration, and reversed vision loss in mouse models. Life Biosciences, a company Sinclair co-founded, has now moved the technology into a first-in-human Phase 1 trial involving people with open-angle glaucoma or non-arteritic anterior ischemic optic neuropathy.David explains how the therapy is delivered directly into the eye and activated using doxycycline, allowing clinicians to control when and for how long the genes are expressed. He also describes the development path that could follow if the treatment proves safe, including therapies targeting the liver and other organs, as well as future medicines that may reproduce similar effects without gene delivery.The conversation then turns to interventions available today. David distinguishes between promising research and claims that have moved ahead of the evidence, discussing NMN, injected NAD, growth hormone, testosterone, taurine, nattokinase, metformin, berberine, and nootropics.Throughout the episode, he emphasizes that no supplement has been shown to reproduce the effects researchers are attempting to achieve through partial epigenetic reprogramming—and that many of the most dramatic claims circulating online remain unsupported.Editorial Note:ER-100 is an investigational therapy. Authorization to begin a clinical trial does not mean the treatment has been proven safe or effective, nor has it been approved for clinical use.The Phase 1 study is primarily evaluating safety and tolerability, with additional measurements of visual function. Results from mice and nonhuman primates do not establish that the therapy will restore vision or reverse biological aging in people.The discussion of supplements, prescription medications, hormones, and lifestyle practices reflects the speakers' personal views and interpretation of the research. It should not be treated as individualized medical advice. Prescription drugs, hormones, supplements, and experimental longevity treatments should be discussed with an appropriately qualified healthcare professional.What You'll Learn:How partial epigenetic reprogramming differs from completely resetting a cell into a stem cell.Why researchers selected three Yamanaka factors—OCT4, SOX2, and KLF4—instead of using all four.What ER-100 is designed to do and why the first human trial focuses on the optic nerve.How doxycycline acts as an external switch controlling when the therapeutic genes are expressed.What Phase 1 researchers will measure and what would need to happen before ER-100 could become an approved treatment.Why the eye provides a useful starting point for testing cellular rejuvenation.What animal studies suggest about restoring vision, memory, liver function, joints, and skin.Why delivering rejuvenation therapies throughout the body is more difficult than treating one localized organ.The difference between oral NMN supplementation and intravenous or subcutaneous NAD.What current research does—and does not—show about growth hormone, testosterone, taurine, metformin, and berberine.Why muscle, exercise, sleep, diet, glucose regulation, and inflammation remain important even if rejuvenation therapies eventually succeed.How Sinclair's laboratory is searching for pills and small molecules that could mimic epigenetic reprogramming without gene therapy.Timestamped Chapters:[04:53] The First Human Trial Begins David discusses ER-100, FDA authorization, and the treatment of open-angle glaucoma and ischemic optic neuropathy.[06:52] What Are the Yamanaka Factors?How reprogramming genes can reset cellular instructions—and why using all four factors can be dangerous.[08:56] Reversing Vision Loss and Memory Problems in AnimalsDavid describes studies involving the eyes, brain, skin, kidneys, liver, and age-related cognitive decline.[10:09] Why Four Factors Can Cause CancerThe difference between restoring youthful function and erasing a cell's identity completely.[10:54] The Three-Gene BreakthroughHow Sinclair's student Yuancheng Lu persisted through years of failure and identified the OSK combination.[12:03] Pulsing the Genes vs. Leaving Them ActivatedEarlier four-factor experiments required intermittent activation, while OSK showed a different safety profile in animal eyes.[13:36] The Doxycycline Safety SwitchHow clinicians may use an antibiotic to activate and deactivate the therapy after it has been delivered.[14:51] Treating the Cause Instead of the SymptomsDavid argues that restoring younger tissue function could allow the body to repair damage associated with age-related disease.[16:02] Why the Trial Starts With the EyeLocalized delivery reduces systemic exposure and makes visual changes easier to observe and measure.[16:50] Can the Therapy Reach the Brain and the Rest of the Body?The challenges of distributing gene-based treatments evenly across organs and through the blood-brain barrier.[18:25] What the Phase 1 Trial Will MeasureSafety, tolerability, visual function, and the possibility of an accelerated development path.[20:36] Expanding Beyond GlaucomaWhy each organ may require a different delivery vehicle—and how the liver could become another early target.[21:38] How Shinya Yamanaka Found the Original Four FactorsThe trial-and-error process that turned adult cells into induced pluripotent stem cells.[22:38] How ER-100 Is DeliveredDavid explains the OSK genes, the AAV delivery system, doxycycline activation, and why manufacturing is expensive.[25:21] When Could the Treatment Become Available?David gives his most optimistic development timeline and discusses parallel programs targeting other organs.[27:31] NMN, NAD, Sirtuins, and the Information Theory of AgingHow declining NAD levels may affect cellular defenses and the regulation of gene expression.[31:34] Oral NMN vs. Injected NADWhy David believes oral supplementation currently has more rigorous evidence than NAD injections.[32:20] Longevity Misinformation OnlineDavid explains why he is restarting his show and warns against confident recommendations unsupported by research.[32:41] Growth Hormone and LifespanWhy growth hormone may improve certain functions but has not been shown to slow aging or extend human life.[34:05] Testosterone, Muscle Mass, and Healthy AgingPotential benefits for maintaining muscle—and why testosterone alone should not be considered a longevity treatment.[36:01] Taurine, Nattokinase, and Changing Your MindWhy David stopped taking taurine regularly and what prompted his interest in nattokinase.[37:30] David's Current Diet and His 86-Year-Old FatherLower meat and cheese consumption, little alcohol, exercise, supplements, and tracking inflammation through biomarkers.[39:33] James's Longevity RoutineLimited processed sugar, intermittent fasting, reduced meat and alcohol, and prioritizing eight hours of sleep.[40:07] Why Sleep Cleans the BrainThe relationship between sleep, waste removal, protein accumulation, cognition, and dementia risk.[40:33] Metformin as a Possible Longevity DrugWhy a medication developed for type 2 diabetes remains central to aging research.[41:41] Berberine and Mitochondrial FunctionWhat clinical studies suggest about glucose regulation and why David sometimes alternates berberine with metformin.[43:10] Modafinil, Adderall, and NootropicsPossible short-term benefits for focus weighed against uncertainty about long-term consequences.[43:43] What Comes After the Eye Trial?Potential applications involving the liver, lungs, kidneys, joints, brain, and other age-related conditions.[45:14] Can Rejuvenation Make Skin Look Younger?David describes unpublished work involving human skin, wound healing, and orally delivered compounds in mice.[46:17] Beyond Gene Therapy: A Rejuvenation PillHow AI and chemical screening may help reproduce the effects of early embryonic reprogramming more cheaply and simply.[47:31] When Could Chemical Reprogramming Reach Humans?David discusses the preclinical safety work and the uncertainty surrounding future human studies.[48:11] The Lifespan Community and FoundationDavid introduces his new show, longevity community, and support for scientific research.Additional Resources:ER-100 Phase 1 Trial — ClinicalTrials.govOfficial registration for the first-in-human study evaluating ER-100 in open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy.Life Biosciences: FDA Clearance for ER-100The company's January 2026 announcement that the FDA cleared its Investigational New Drug application.Life Biosciences: First Participant DosedThe June 2026 announcement marking the start of dosing in the Phase 1 trial.“Reprogramming to Recover Youthful Epigenetic Information and Restore Vision” — NatureThe 2020 mouse study reporting that OSK expression restored youthful epigenetic patterns, promoted nerve regeneration, and reversed vision loss.The Sinclair Lab at Harvard Medical SchoolResearch, publications, laboratory members, and information about David's work on the biology of aging.Lifespan: Why We Age—and Why We Don't Have ToDavid Sinclair and Matthew LaPlante's 2019 book about the biology of aging and emerging longevity research.LifespanDavid's longevity show, research magazine, community, and information about the Lifespan Foundation.NMN Human-Trial Review — PubMedA review of the safety evidence and proposed effects of nicotinamide mononucleotide in human clinical studies.NMN and Physical Performance — PubMedA systematic review examining randomized trials of NMN and physical-performance measurements.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Michael Hamflett and Michael Sidgwick review NXT and discuss...Great American Bash FALLOUT!Naraku blinds Tony D'Angelo AGAIN!Kendal Grey and Wren Sinclair celebrate with cake!Lizzy Rain ROCKS OUT!Another New Arrival! Hosted on Acast. See acast.com/privacy for more information.

Ecoutez Le Cave' réveil avec Philippe Caverivière du 30 juin 2026.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                               __________________________________________ In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging. Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk. Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

From ultrasound photos to graduation pictures, many parents share their children's lives online. For some families, these posts help maintain connections with friends and relatives or build supportive parenting communities. But what does it mean for children to grow up with a digital footprint that begins, in some cases, before they are even born? Keneisha Sinclair-McBride, PhD, discusses the psychology of "sharenting," the privacy and safety risks of sharing in the age of AI, and how families can balance connection and community with children's need for autonomy and control over their own stories. Learn more about your ad choices. Visit megaphone.fm/adchoices

Um computador com as palavras certas...

Ending televising, Sinclair's flights, a dream social club, ‘Sam!', cheap booze, and summer freedom. Join the Iron Filings Society: https://www.patreon.com/topflighttimemachine and on Apple Podcast Subscriptions. Get a 7-day full access free trial and pay for 10 months up front for the price of 12 if you like a bargain. Hosted on Acast. See acast.com/privacy for more information.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                               __________________________________________ In this first episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and pioneer in longevity research - returns and explores one of the most consequential questions in science: How can aging be slowed or reversed? Drawing on more than 25 years of research at the forefront of aging biology, Dr. Sinclair explains why humanity has entered a revolutionary period. Advances in science and technology have converged and transformed aging into a promising target for intervention. This episode is a sweeping introduction to the science, breakthroughs, and emerging technologies that are fundamentally reshaping how we think about aging, disease, and the future of human health.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

In the 1980s and early 1990s, a terrifying series of murders occurred connected to the so-called "Coin Shop Killer," believed to be longtime suspect Charles Thurman Sinclair. Multiple coin shop owners across several states were targeted using a chillingly consistent method: a friendly, knowledgeable customer would gain trust before returning to rob and murder the shop owners. Join Mike and Morf as they discuss the "Coin Shop Killer." An interstate investigation linked the crimes at a time when cooperation between agencies was far less common than today. But there are still many unanswered questions involving these cases. Although a lot of evidence was found against Sinclair, he never made it to trail, and he took his secrets with him when he died.   You can help support the show through Patreon. We'd love to connect with listeners on social media. We are available on the following platforms: Facebook - Facebook Discussion group - Instagram - Threads - X Formerly Twitter - Blue Sky - Twitch - Tik Tok  Criminology is an Emash Digital production hosted by Mike Ferguson and Mike Morford.