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In this episode, CardioNerds Dr. Daniel Ambinder, Dr. Giselle Suero Abreu, and Dr. Saahil Jumkhawala discuss thromboembolic disease in cardio-oncology with faculty expert Dr. Joshua Levenson, the Associate Program Director of the cardiology fellowship and an Assistant Professor of Medicine at the University of Pittsburg School of Medicine. Venous (VTE) and arterial thromboembolic (ATE) events are precipitants of morbidity and mortality in patients with cancer. Here, we discuss the pathophysiology of thromboembolism, risk factors and epidemiology for ATE and VTE, the role of risk prediction and patient stratification, and the approach to treatment for and prophylaxis of thromboembolic events with anticoagulation. Show notes were drafted by Dr. Saahil Jumkhawala and episode audio was edited by CardioNerds Intern Dr. Tina Reddy. This episode is supported by a grant from Pfizer Inc. This CardioNerds Cardio-Oncology series is a multi-institutional collaboration made possible by contributions of stellar fellow leads and expert faculty from several programs, led by series co-chairs, Dr. Giselle Suero Abreu, Dr. Dinu Balanescu, and Dr. Teodora Donisan. CardioNerds Cardio-Oncology PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Thromboembolic Disease in Cardio-oncology Patients with cancer are at higher risk of developing both arterial and venous thromboembolic events compared to the general population. Certain cancer subtypes are associated with a relatively higher risk of developing thromboembolic complications. Anticoagulation type and duration should be dependent on patient characteristics and risk factors, with shared decision-making between the patient and their providers. Subgroups of patients may benefit from more aggressive management of their atherosclerotic cardiovascular risk factors while being treated for cancer to reduce the risk of thromboembolic complications. Show notes - Thromboembolic Disease in Cardio-oncology What are the incidence and main manifestations of thromboembolic events (venous and arterial) in patients with active malignancy? Approximately 10% of outpatients with active cancer have venous thromboembolic events, many of which are asymptomatic. Clinically relevant VTEs are predominantly deep venous thrombosis (DVTs) with pain and/or swelling of the involved extremities or pulmonary emboli (PEs) resulting in chest pain and/or shortness of breath. VTE is the number one preventable cause of death for all hospitalized patients, and the ability to prevent and treat these events is crucial, particularly in high-risk populations such as patients with cancer. Are there any high-risk associations with specific cancer subtypes? Patients with metastatic disease and those receiving chemotherapy are more likely to develop arterial or venous thromboembolic events. Patients with acute myelogenous leukemia (AML) and thrombocytopenic patients are at the lowest risk for thromboembolic events. Multiple myeloma patients on medication such as proteasome inhibitors or lenalidomide appear at particular risk. Patients with localized, early-stage cancers such as breast, prostate, and melanoma are also at lower risk. What are the main risk factors to identify patients at a higher risk of developing thrombotic complications? Patients with a sedentary lifestyle, deconditioning, and undergoing active treatment with chemotherapy are at the highest risk of developing DVT or PE. How should we approach choosing the optimal type and duration of anticoagulation for acute pulmonary embolism (PE) in the setting of malignancy? This remains an area of active research. Historically, patients would receive systemic anticoagulation with heparin followed by warfarin.
In today's special episode recorded LIVE at ClioCon I spoke with Kevin Buckley of the Torrey Pines Law Group. Kevin is an accomplished international patent attorney & executive. He founded Torrey Pines Law Group in 2013 to help his clients bring lifesaving, enduring, and commercially valuable technologies to market after previously working in Big Law. He recently earned the Clio Reisman Award for Best Growth Story for his work and the work of his law firm during the Covid 19 pandemic. Kevin is a graduate of US San Diego where he studied Biochemistry and the University of Pittsburg School of Law. In our conversation we discuss the importance of finding what you are good at, what patent attorneys do (and how that has changed through his career), the importance of connecting business/law/science especially in today's historical moment, and why they best skill to learn is how to constantly learn from the smart people around you. This episode is sponsored, edited, and engineered by LawPods, a professional podcast production company for busy attorneys. *** Want to Support the Podcast in 2 minutes or less? Leave a Review (this helps the algorithm connect me to new listeners) Subscribe on iTunes or Spotify Purchase How I Lawyer Merchandise Share on LinkedIn or Twitter
In this episode, Ian speaks with Dr. Theresa Koleck from University of Pittsburg School of Nursing about her expertise in omics and biomedical informatics. Dr. Koleck recently published a fascinating first-author paper in Nursing Research focused on the use of natural language processing (NLP) in the study of five deliberately selected symptoms. This project was a methodologically-focused feasibility pilot of the use of NLP and the NimbleMiner R-Studio Shiny package, created by one of her nurse scientist colleagues at Columbia University (Dr. Max Topaz). Additionally, they discuss Dr. Koleck's broader interests in symptoms and symptom burden.
Jabeen Adawi has dedicated her legal career to serving victims of gender-based violence and underserved communities. From litigation to non-profit work to clinical teaching, she navigated changes in her legal career in the midst of navigating the challenges of young motherhood. In this episode, Jabeen shares the lessons that have helped her thrive at home and in her career, ultimately leading to a leadership position as the Director of the Family Law Clinic at the University of Pittsburg School of Law. Connect with Jabeen Adawi at:Jabeen Adawi | School of Law | University of PittsburghFamily Law Clinic | School of Law | University of PittsburghLinkedIn: Jabeen AdawiMom Life and Law is a podcast for lawyer moms who are expected to mother as if they have no job and lawyer as if they have no children. In the face of these expectations, I give you strategies to help you thrive. Each week, invest some time to reframe your mindset, own your power, and set yourself up for success. You deserve it.Connect and Follow Mom Life and Law at:www.momlifeandlaw.comFacebook: @momlifeandlawInstagram: @momlifeandlawTwitter: @momlifeandlawLinkedIn: Mom Life and Law
In this episode, I am speaking with Vincent Johnson, Director of Diversity and Inclusive Excellence at Pittsburg School of Law. We talk about some of the VISIONS tools, and how he has incorporated those tools to create change across students, faculty, and staff. He shares the importance of D.E.I. work with First-Year students and the ways he has seen the positive impacts of the work.
Host: Brian P. McDonough, MD, FAAFP Dr. Brian McDonough speaks with Dr. Philip E. Empey, PharmD, PhD, Assistant Professor of Pharmacy and Therapeutics at the University of Pittsburg School of Pharmacy. Their discussion centers on advancements in genetic testing to detect variances in response to anticoagulation therapies for patients undergoing vascular procedures such as stent placements.
Host: Matt Birnholz, MD Dr. Matt Birnholz welcomes Dr. Clifton Callaway, Professor and Executive Vice Chairman of the Department of Emergency Medicine at the University of Pittsburg School of Medicine. Dr. Callaway received ACEP's Outstanding Contribution to Research Award for his more than two decades of research dedicated to improving brain resuscitation after cardiac arrest. He joins Dr. Birnholz to discuss a research-guided evolution in resuscitation protocols based on improved physiological understandings of secondary brain injuries, comas, and recoveries.
Host: Matt Birnholz, MD Dr. Matt Birnholz welcomes Dr. Clifton Callaway, Professor and Executive Vice Chairman of the Department of Emergency Medicine at the University of Pittsburg School of Medicine. Dr. Callaway received ACEP's Outstanding Contribution to Research Award for his more than two decades of research dedicated to improving brain resuscitation after cardiac arrest. He joins Dr. Birnholz to discuss a research-guided evolution in resuscitation protocols based on improved physiological understandings of secondary brain injuries, comas, and recoveries.
In this KosmosOnline podcast, Jeanne Hoffman talks with Joseph Packer about World of Warcraft and spontaneous order. Mr. Packer is a PhD student at the University of Pittsburg School of communication and is the author of the paper “Dethroning the author, when fiction and reality collide in MMORPG‟s.”