Podcasts about clinically

In this episode, Dr. David Jockers breaks down the secret truth about nitric oxide and why it's essential for blood pressure, libido, and memory. You'll learn how this molecule boosts circulation, supports organ health, and protects your brain. Discover simple strategies to optimize nitric oxide naturally.   You'll uncover the key signs of low nitric oxide, from fatigue and poor sleep to aging skin and low libido. Dr. Jockers explains the different forms of nitric oxide and how to maximize the good ones while reducing inflammation caused by the harmful forms.   Learn the most effective ways to boost nitric oxide safely, including nutrient-rich foods, movement, sunlight, and targeted supplementation. You'll understand why some popular supplements may do more harm than good and what really works to enhance energy, circulation, and sexual function.   In This Episode:  00:00 Nitric Oxide Benefits Teaser 00:20 Podcast Welcome and Episode Overview 03:11 Why Nitric Oxide Matters 04:20 What Nitric Oxide Is 05:01 Low Nitric Oxide Symptoms 05:34 Three Types of Nitric Oxide 07:06 Big Health Benefits Explained 09:47 Why Levels Drop With Age 11:01 Nutrition for More Nitric Oxide 12:11 Oxalates and Best Nitrate Foods 13:04 Arginine From Food Basics 15:47 Exercise Stress Sleep and Sunlight 17:24 Supplements Omega 3 and B Vitamins 20:10 Nitric Oxide Supplements What to Avoid 22:43 Better Options Citrulline and NO Powder 23:51 Key Takeaways and Final Sendoff 24:27 Podcast Outro Reviews and Sharing   Transform thin, lifeless hair into fuller, stronger strands with Hydra Lift Volumizing Shampoo by Pureance. Packed with wheat protein to strengthen follicles and betaine from sugar beets to hydrate and soften, it's USDA-certified organic and safe for you and the environment. Try it risk-free today and save 35% with code JOCKERS at Pureance.com   Stress is silently aging your body, but PurAlity Health's KSM-66 Ashwagandha tackles it naturally. Clinically proven to reduce cortisol, improve memory, sleep, metabolism, and blood oxygen, it uses nano-absorption for full effect. For a limited time, enjoy a Buy One, Get One Free offer with a 180-day money-back guarantee at longevityroot.com/drj.   "Healthy nitric oxide levels protect your brain and reduce the risk of Alzheimer's."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Revive your hair! 35% off with code JOCKERS at Pureance.com. Crush stress naturally! BOGO + 180-day guarantee at longevityroot.com/drj.   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

In this episode the guys break down the four biggest fitness traps of 2026 — over-reliance on wearables and tech, the GLP-1 shortcut and muscle loss crisis, chasing longevity fads over basics, and aesthetics over everything. They also get into the alien.gov website reveal (spoiler: not what anyone expected), the black market GLP-1 side hustle spreading through social circles, a new study showing resistance training beats cardio for fat loss head to head, and Doug's 30-day Dose liver enzyme experiment update. Then they coach live callers submitted through mplivecaller.com — Aidan from Kansas on lingering strength and nerve issues after mono, Jamie from Oklahoma on rebuilding her relationship with food and training after anorexia and overtraining, and Caleb from Pennsylvania who shares an inspiring 18-month reverse diet success story before getting help with chronic forearm pain. MAPS Summer Sale — https://mapsfitnessproducts.com Code: SUMMER40 — 40% off everything (programs, bundles, mods & guides) — June 1–14 only SPONSORS Vuori — https://vuoriclothing.com/mindpump 20% off first order — no code needed, automatically applied Dose (liver & cholesterol support) — https://dosedaily.co/MINDPUMP Code: MINDPUMP — 25% off first month subscription. Clinically backed, all-natural liquid supplement. Supports liver enzymes, LDL, HDL and skin health. Fatty15 (C15 essential fatty acid) — https://fatty15.com/MINDPUMP Code: MINDPUMP — additional 15% off the 90-day Starter Kit subscription. C15 has been shown to have 3x more cellular benefits than omega-3. LINKS Submit a live caller question: https://mplivecaller.com  Mind Pump Store: https://mindpumpstore.com  Maps Fitness Products: https://mapsfitnessproducts.com  Instagram: @mindpumpmedia 0:00 - Intro 2:12 - Fitness trap #1: Over-reliance on wearables and tech — when data becomes a stressor 8:21 - Fitness trap #2: GLP-1 and the muscle loss crisis — what nobody is telling you 16:36 - Fitness trap #3: Chasing longevity fads while ignoring the basics 20:56 - Fitness trap #4: Aesthetics over everything — why chasing the look kills the look 33:23 - Vuori — the random guy at the park who wouldn't stop complimenting Sal's joggers 44:57 - Resistance training vs. cardio for fat loss — new head to head study 47:57 - Dose liver supplement — skin benefits and Doug's 30-day cholesterol experiment 55:43 - Alien.gov — the government website reveal nobody saw coming 59:33 - Caller: Aidan (Kansas) — college swimmer, post-mono nerve issues, lost 100lbs on bench 1:13:13 - Caller: Jamie (Oklahoma) — anorexia history, overtraining, inner thigh pain, gets a coach 1:27:24 - Caller: Caleb (Pennsylvania) — 18-month reverse diet success story, now dealing with forearm pain  

AUA Guidelines: Clinically Localized Prostate Cancer Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: James Eastham, MD, FACS To access the full guideline, please use the following link: https://www.auanet.org/guidelines-and-quality/guidelines/clinically-localized-prostate-cancer

The "Busy" Trap in DentistryFor Future Dental Practice Owners, a packed schedule feels like success. Yet, a booked day lacking strategic production leads to clinical burnout. Dr. Andrew Clingan and Caitlin Embree reveal why being merely "busy" destroys dental practice profitability. Moving from clinician to empowered CEO means stopping the cycle of stepping over dollars to pick up pennies. This requires mastering dental practice management through intentional scheduling.Your Scheduling Survival Guide:If your days are chaotic but collections are stagnant, your systems are failing. Allowing patients to cancel restorative work without consequence is why dental practice profitability drops. You cannot achieve sustainable dental practice growth if your team scrambles for supplies instead of prepping same-day treatment. To implement elite dental business strategies, engineer your operations:Implement Block Scheduling: Define daily "rocks" and "boulders" to hit goals before filling gaps.Enforce Front Desk Protocols: Separate doctor time from assistant time to end bottlenecks.Demand Accountability: Stop absorbing no-shows by collecting upfront deposits for major cases.Optimize Back-Office Systems: Standardize inventory so your team can add same-day treatment.Dr. Clingan shares how these systems turned a routine limited exam into a prepaid $17,000 case in ten minutes. This operational mindset lays the foundation for scalable dental business ownership and predictable dental practice profitability. It is vital for the associate to owner transition.Ready to take the next step in your dental practice journey? Visit https://sharedpractices.com to learn more about our Buyer Representation and Coaching services, designed to help dentists buy, grow, and optimize profitable practices. You can also use our Free Look to evaluate dental practice opportunities with real data before making a decision. For daily Dental Moneyball insights, strategy tips, and updates, follow us across our social channels.

The text messages Mackenzie Shirilla sent Dominic Russo were controlling, threatening, and ugly. The TikTok persona was image-obsessed. The arrest behavior was bizarre. Everything about her personality fed a narrative that she was cold enough to plan a murder at seventeen. A judge agreed. But a psychotherapist who has treated both victims and perpetrators of violence for over thirty years reads the same evidence and sees a completely different clinical picture.Shirilla was convicted of four counts of murder for the Strongsville, Ohio crash that killed Dominic Russo and Davion Flanagan. Netflix's The Crash has reignited the debate over whether this was premeditated or something else entirely. But the psychological dimension — the question of what's actually happening inside someone who behaves the way Mackenzie did — barely gets examined.Shavaun Scott, author of The Minds of Mass Killers, brings three decades of clinical experience to the personality profile that convicted Mackenzie Shirilla. The narcissism the public sees as proof of coldness? Clinically, it almost always signals the opposite — someone with no stable sense of self, terrified of abandonment, constructing an identity out of image because there's nothing solid underneath. The ultimatums and threats? Driven by desperation, not calculation. The volatility? Possibly personality disorder, possibly a teenage brain that hasn't finished developing. The distinction between those two things matters enormously — and the trial never explored it.This conversation goes where the documentary and the courtroom didn't — inside the clinical reality of who Mackenzie Shirilla actually is, not who the prosecution needed her to be.Join Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1Instagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/TrueCrimePodThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.#MackenzieShirilla #TheCrash #TheCrashNetflix #DominicRusso #DavionFlanagan #ShavaunScott #HiddenKillers #TrueCrime #Netflix #CriminalPsychology

Sun protection you can eat? Yes, you heard that right. This week, we're joined by Dr. Noreen Galaria as she walks us through the many facets of the polypodium leaf. Listen in as she discusses sun protection, supplement standards, and the very latest research on conventional and traditional treatments. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com. Noreen Galaria, MD FAAD is a board certified Dermatologist with a laser and cosmetic fellowship and has been practicing for over 20 years. After spending time as an academic dermatologist; training residents and doing research and publishing papers she moved into private practice 15 years ago and opened 3 offices outside of the DC area. Her research spans both conventional allopathic medicine and evidence based naturopathic therapies with a focus on integrative dermatologic care. She is also the CEO and Founder of Inner Glow Vitamins (A Dermatologist and Plastic surgeon developed brand of skin nutraceuticals). ¹ Research on polypodium has been published and presented at leading dermatology conferences, including the American Academy of Dermatology (AAD) and the Society for Pediatric Dermatology (SPD). Archives of Dermatological Research (2025) 317:580. https://doi.org/10.1007/s00403-025-04055-8 | Thakker S, Hussain A. J Am Acad Dermatol. 2025;93(3 Suppl):AB320. | Hakim C, et al. Presented at SPD 50th Annual Meeting; July 2025; Seattle, WA.

Vincent (Vinney) Tolman died in 2003 in a Dairy Queen bathroom after taking an accidental overdose of a supplement. Clinically dead, he was bagged and transported to a medical examiner. A rookie medic broke protocol and resuscitated him. What makes his case compelling: while clinically dead, Vinney had verifiable experiences that challenge our understanding of consciousness  and what happens when we die.   While his body lay dead in a bathroom, Vinney's consciousness watched from outside his body. He observed paramedics attempting resuscitation, watched his body being bagged, saw the ambulance, and witnessed specific medical procedures including defibrillation shocks. He watched his arm being strapped down in the ICU. When he reconnected with his body, he could verify details he had no way of knowing while unconscious. He also had some remarkable and transformational experiences in a non physical dimension. Including some people and beings he met there, which later provided shocking evidence that something very real was going on.   Vinney's case included observable elements that corroborate his account. He describes what he saw while dead, what was verifiable, and what this suggests about consciousness continuing after brain death. This is a documented case of someone who experienced verifiable events while clinically dead, providing evidence that consciousness may exist independently of brain function. Guest: Vinney Tolman https://livinggodslight.org/ Buy my Books HERE ⁠⁠⁠⁠Newsletter ⁠⁠⁠| Buy me a coffee Join a Science and Spirituality Salon  More at: https://www.wtfjusthappened.net/ IANDS CONFERENCE International Association for Near Death Studies August 27th - 30th Seattle, Washington Join Us Forever Family FoundationLove Knows No Death Summer Grief Transformation Retreat 2026July 24 @ 4:00 pm - July 26 @ 5:30 pm Chester, Connecticut Join us!

If you've been told you have "unexplained infertility" — Dr. Stephanie Gray says it's not unexplained. It's undiscovered. She spent 10 years uncovering 6 hidden variables that finally helped her conceive. Today she's sharing all of it, plus the faith that carried her through.  Dr. Stephanie Gray spent a decade navigating infertility while running her own hormone clinic. In this powerful conversation, she pulls back the curtain on the six hidden variables conventional medicine missed — and how functional medicine, faith, and following her own intuition finally led to her two sons.What You'll Hear:Why "unexplained infertility" is actually undiscovered infertilityThe 6 hidden variables Dr. Gray uncovered in her own fertility journey: structural issues (endometriosis, infections), toxins, stress, trauma, gut dysfunction, and blood flow disordersWhat the 100-day window is — and why it changes everything about egg and sperm qualityWhy AMH levels are not a death sentence (and how Dr. Gray has watched them change)The faith piece: how to pursue medicine AND trust God at the same timeDr. Stephanie reads the fertility prayer from her book — have tissues ready Dr. Stephanie Gray, DNP — Founder of Integrative Health and Hormone Clinic and Your Longevity Blueprint Nutraceuticals. Triple board-certified, functional medicine trained, and the author of The Fertility Blueprint.Resources Mentioned:

Julia T. Woodward, Ph.D. is a Professor in the Departments of Psychiatry & Behavioral Sciences and Obstetrics & Gynecology in the Duke University Health System. She has directed the Patient Support Program at the Duke Fertility Center for over 20 years. Clinically, she specializes in working with patients facing infertility, pregnancy loss, third-party reproduction, fertility preservation, and perinatal mood disorders. She trains Clinical Psychology PhD students, Predoctoral Interns, and Postdoctoral Fellows as well as REI Fellows and OBGYN residents in the psychosocial aspects of reproductive medicine. She has held multiple committee leadership positions in the Mental Health Professional Group of the American Society for Reproductive Medicine, is the current Chair of the Scientific Development Committee and previously served on the Executive Council for the Society for Assisted Reproductive Technology (SART). She serves as an Associate Editor for Human Reproduction. She publishes regularly and lectures internationally on the psychosocial aspects of reproductive medicine, integration of mental health services into fertility care teams, and later-life parenting. CONNECT WITH DVORA ENTIN: Website: https://www.dvoraentin.com/ Instagram: https://www.instagram.com/dvoraentin YouTube: https://www.youtube.com/@misconceptionspodcast  

In this episode of The Lead, host Melissa Middeldorp, MPH, PhD, FHRS is joined by Jenelle Dziano, PhD candidate, Clinical Exercise Physiologist and Adrian D. Elliott, PhD for a discussion of the recent journal article, Exercise Capacity and Quality-of-Life Improvements after Catheter Ablation in Patients with Clinically Asymptomatic Persistent Atrial Fibrillation. Together, they explore the study findings and discuss the impact of catheter ablation on exercise capacity and quality of life in patients with clinically asymptomatic persistent atrial fibrillation. Learning Objectives Review the key findings from the journal article examining exercise capacity and quality-of-life outcomes after catheter ablation in patients with clinically asymptomatic persistent atrial fibrillation. Discuss the potential clinical implications of catheter ablation for patients who may not report traditional atrial fibrillation symptoms. Explore the role of exercise capacity and quality-of-life measures in evaluating treatment outcomes for persistent atrial fibrillation. Podcast Contributors: Host: Melissa Middeldorp, MPH, PhD, FHRS Guests: Jenelle Dziano, PhD candidate, Clinical Exercise Physiologist and Adrian D. Elliott, PhD Host and Contributor Disclosure(s): M. Middeldorp: Nothing to disclose J. Dziano: Nothing to disclose A. Elliiott: Nothing to disclose

In this episode, Dr. Jockers breaks down allulose, the natural sugar alternative that has minimal impact on blood sugar and insulin. You'll learn why it's a keto-friendly option that supports fat burning and can replace sugar in recipes without digestive issues. We explore how allulose promotes liver health, improves cholesterol, and aids in metabolizing fat around your organs. You'll also hear how it interacts with beneficial gut bacteria to create postbiotics that strengthen your intestinal lining. Discover practical tips for using allulose in everyday cooking and baking, including adjusting temperatures and times for optimal results. By the end, you'll understand why this sweetener is gaining attention among functional health experts and how it can fit into your lifestyle.     In This Episode:  00:00 Allulose Absorption Basics 01:32 Sugar Problems Sweetener Alternatives 03:19 What Is Allulose 04:15 Baking With Allulose Tips 05:01 Digestion Tolerance Explained 06:17 Blood Sugar Insulin Benefits 09:05 Liver And Gut Health Perks 11:16 How To Use And Buy Allulose 13:28 Choosing Sweeteners Avoid Processed 14:44 Final Baking Reminders Wrap Up 15:42 Podcast Closing And Reviews   If you want to burn belly fat…boost your energy levels…balance blood sugar…or relieve swelling in your legs or feet… Then you need to check out PureHealth Research immediately.   This company makes some amazing health-boosting supplements that are manufactured right here in America. They only use natural, non-GMO ingredients that are backed by the latest science and proven to work.   And right now, you can save 35% on all of their products with this special subscriber-only offer. Just use your exclusive coupon code JOCKERS at checkout.   Upgrade your hair routine effortlessly with the iRestore Elite, an at-home device using 300 lasers and 200 LEDs to stimulate hair regrowth. Clinically proven to help restore fuller, healthier hair, it works while you relax, watch TV, or journal. Pair it with the Revive+ Max Growth kit or Biotin Gummies for extra support. Right now, get an exclusive discount with code DRJOCKERS at iRestore.com and start your hair transformation today!   "Allulose has about 90% fewer calories and very little impact on your blood sugar, making it keto-friendly and safe for diabetics."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit https://www.purehealthresearch.com/ - Use code DRJOCKERS for 35% Use code DRJOCKERS at https://irestore.com/ to claim your discount today!     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.

What happens when you experience MS symptoms, but don't yet have a diagnosis? In this episode of Living Well with MS, we hear from Maureen Haith, who first experienced neurological symptoms in 2002 but wasn't diagnosed with multiple sclerosis until 2019. Along the way, she was told she had clinically isolated syndrome (CIS) – a term many people are unfamiliar with, but which can be an early stage of MS. Maureen shares her experience of recognising early symptoms, navigating uncertainty, and deciding when and how to tell others about her condition. She also reflects on how discovering the Overcoming MS programme influenced her lifestyle, from diet and exercise to building community through local support groups. This is a thoughtful and reassuring conversation for anyone facing MS diagnosis uncertainty, exploring practical ways to take control and make sustainable lifestyle changes over time. Watch this episode on YouTube. Keep reading for the topics, timestamps, and our guest's bio.   02:02 First MS symptoms: fatigue, tingling and early warning signs 03:49 New symptoms appear: changes in walking and sensation 04:55 What is clinically isolated syndrome (CIS) and why it matters 07:38 Deciding when and how to share an MS diagnosis 11:37 MS risk and family: understanding genetics and environment 14:23 Discovering Overcoming MS and making lifestyle changes 16:35 Finding support: building connection through local MS circles 20:19 Following the MS diet while travelling and eating out 26:03 Managing weight on a whole food plant-based diet 29:29 Coping with brain fog: practical tools that help 31:33 Advice for newly diagnosed: start small and build gradually Read all of the Overcoming MS books Find plant-based restaurants on the Happy Cow website Check out the Chef Cards for eating in a restaurant New to Overcoming MS? Learn why lifestyle matters in MS - begin your journey at our 'Get started' page Connect with others following Overcoming MS on the Live Well Hub Visit the Overcoming MS website Follow us on social media: Facebook Instagram YouTube Pinterest Don't miss out: Subscribe to this podcast and never miss an episode. Listen to our archive of Living Well with MS here. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. Support us: If you enjoy this podcast and want to help us continue creating future podcasts, please leave a donation here. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. If you like Living Well with MS, please leave a 5-star review.

"The biggest thing I experienced in hell, more than the fire, more than the pain, more than the sights that I saw, was the pain of regret." Pastor Dominic MorrowWhat happens when the person you built yourself to be is the exact person standing between you and eternity?Pastor Dominic Morrow grew up in Chicago between two worlds. Half African-American and half Afro-Cuban, raised between Christianity and Santeria. By his teens he was deep in gang life, selling drugs, and surrounded by people who feared him. He thought religion was for the weak.Then in June 2009, he was shot twice in the stomach. Clinically dead for 3 minutes and 47 seconds. In that time, he went somewhere.In this episode of the Earth Xperience Podcast, Pastor Dani sits with Dominic for a conversation that does not stay on the surface. He walks through leaving his body, falling faster than the speed of thought into a living darkness, arriving at the gates of hell, and what the Lord showed him before sending him back. He breaks down what demons actually are, how Santeria disguises darkness as light, and why regret is the greatest pain a soul can carry.This is also a story of rebuilding. After coming back, Dominic moved through Islam and Hebrew Israelite teachings before fully anchoring his faith in Yeshua. He founded the Narrow Path Society and Blessed to Be Chosen ministry and authored three books including 3 Minutes and 47 Seconds in Hell.Topics: near death experience, NDE, hell testimony, afterlife, spiritual warfare, gang life, Chicago, Santeria, Yeshua, Jesus Christ, redemption, regret, eternity, second chances, life after death, deliverance, out of body experience, faith.Questions to sit with:What will you regret most at the end of your life, and what are you doing about it now?What beliefs did you inherit from your family or culture that you have never fully examined?What would it feel like to see your entire life with total clarity in one instant?Where in your relationships do you see fear holding people together instead of love?Find Dominic Morrow:youtube.com/@DominicMorrowIncblessedtobechosen.comBooks on Amazon: The Toughest Enemy in Life is You, Passport to Eternity, 3 Minutes and 47 Seconds in HellSupport the nonprofit: Cash App at NarrowPathSociety

Episode 223: Oncogenic Viruses Introduction Mehr: Hi everyone, welcome back to the Rio Bravo qweek podcast. Back by popular demand is Me, Mehr Boparai a third-year medical student at COMP-NW. Here with me is Jeremy Pan from COMP who is also a third-year medical student. How are you doing Jeremy? Jeremy: I'm doing great Mehr.Thanks for the kind intro; we had a fun time this morning doing street medicine and had some practice giving Toradol injections and wound dressings. So excited to be back for another podcast episode this afternoon! Mehr: This week, we are moving away from bacteria and antibiotics and diving deeper into cancer-causing viruses. Jeremy: Yes, and if you are interested at all in public health, this is one of those areas where medicine overlaps with public health in a really tangible way. I think one of the most underappreciated aspects of this topic is that we have vaccines that can prevent many of these cancers. If you told someone 50 years ago we'd be vaccinating against cancer, they probably wouldn't believe you! It's amazing to see how far medicine has come. How viruses cause cancer: Jeremy: Before jumping into specific viruses, I always think having a mechanism-based framework makes everything stick better. Mehr: Right, because they don't all cause cancer the same way. Medicine can never be easy huh? Jeremy: Yea…this career really is just a lifetime of discovery. So just to start, in broad terms, we can think of three main buckets of how viruses can cause cancer: Direct oncogenesis where viral proteins interfere with tumor suppressors like P53 and Rb. We will go over their specific mechanisms a little later in the discussion. Mehr:  Chronic inflammation where viruses cause repeated injury through production of reactive oxygen species. They also increase the chance of mutation through repeated DNA replication, leading to cancer.  Jeremy: Immune evasion or suppression leads to decreased tumor surveillance. What this means essentially is that our immune system is constantly removing abnormal cells before they become cancerous. This is completed by CD8 T cells and natural killer, or NK, cells. CD8 T cells recognize abnormal peptides presented on Major Histocompatibility Complex, or MHC, class I molecules and induce apoptosis in those cells. Mehr: And NK cells step in when cells decide to stop expressing MHC I, which abnormal cells like to hide to avoid being caught. So just to reiterate, there are two layers to dissect here: if a cell looks suspicious with an abnormal MHC, CD8 T-cells kill them. If the abnormal cell decides to hide its MHC, then the NK cell will kill it instead. Jeremy: So, for the final big picture, we can think of oncogenic viruses as either disabling tumor suppression, causing chronic damage over time through inflammation, and weakening the immune system's ability to catch cancer in time before it develops. HPV Mehr: Let's start with one of the most common viruses afflicting our population – Human Papilloma Virus otherwise known as HPV.  Jeremy: Right, this notorious virus is probably the most clinically impactful oncogenic virus. The key players HPV utilizes are proteins E6 and E7. Mehr: Right! E6 binds to and inhibits p53, which normally acts to induce cell cycle arrest, and E7 inhibits Rb, which normally acts as a tumor suppressor gene that inhibits the G1 to S phase transition in a normal cell cycle. Jeremy: So essentially, we are losing both apoptosis and losing cell cycle control at the same time. What is interesting about HPV is that persistent infection, not just exposure to the virus, is what drives cancer risk.  Mehr: Exactly, most HPV infections clear on their own, but the ones that persist are the problem. Clinically, many end up being asymptomatic. However, for high-risk infections, we can see genital warts that can itch, feel tender, or cause abnormal vaginal bleeding and discharge. Patients are sometimes not able to have a vaginal delivery because of the warts that are present along their genital tract. We can also see warts on the hands and fingers or plantar surface of our feet. Jeremy: Another interesting point is that we are also seeing a shift where there are more cases of oropharyngeal cancers in younger, non-smoking patients. This is why if we see an abnormal neck lymph node or persistent sore throat after swallowing in a young patient, HPV should definitely be on the differential.  Mehr: Screening is very important as well! We typically discover high-risk HPV infections through routine Pap smears and other HPV specific tests through DNA PCR and RNA tests. We also encourage vaccination for effective prevention of both genital warts and high-risk HPV-related cancers. There was also a study in Scotland where there were zero cases of HPV in adults who received the vaccine between 12-13 years of age! Which is crazy!  EBV HBV & HCV Mehr: Now let's shift to viruses that affect the liver, Hepatitis B virus and Hepatitis C virus. Jeremy: Both are strongly associated with hepatocellular carcinoma, but they actually get there in slightlydifferent ways. Mehr: Right. Hepatitis B is a DNA virus that can integrate directly into the host genome, which can disrupttumor suppressor genes and promote oncogenesis. Jeremy: Whereas Hepatitis C is an RNA virus, so it doesn't integrate into the host genome. Instead, it causes chronic inflammation Over time, that leads to repeated cycles of hepatocyte injury and regeneration, along withoxidative stress from reactive oxygen species, which increases the risk of DNA mutations. Mehr: One really important clinical pearl is that Hep B can actually cause hepatocellular carcinoma evenwithout cirrhosis. Whereas with Hep C, the pathway is usually chronic inflammation → fibrosis → cirrhosis → dysplasia→ cancer.  Jeremy: So, screening becomes really important for both of these viruses. For high-risk patients—like those with chronic hepatitis or cirrhosis—we typically dosurveillance with liver ultrasound every 6 months, sometimes with alpha-fetoprotein levels to see if it is elevated. Mehr: From a prevention standpoint, the Hep B vaccine is a huge win. It significantly reduces the risk ofhepatocellular carcinoma. For Hep C, we don't have a vaccine, but direct-acting antivirals can actually cure the infection andreduce long-term cancer risk, which is why we screen between ages 18-79  nowadays. Global Hep B and C account for 65% of all HCC cases! So, it makes sense that primary care itself is increasing the treatment of Hep C cases as well since it is easier to prescribe and that you want to be treated ASAP.  Jeremy: Yea, the ability to treat Hep C is so beneficial to population health. Now let's say you have a patient who develops hepatocellular carcinoma, options can include surgicalresection, liver transplantation, local therapies, or systemic treatments depending on stage.  Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!  __________________________________ References: Barry H. C. (2024). Scottish Screening: No Cases of Invasive Cervical Cancer in Women Who Received at Least One Dose of Bivalent HPV Vaccine at 12 or 13 Years of Age. American family physician, 110(2), 201–202. https://pubmed.ncbi.nlm.nih.gov/39172683/ Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!

Welcome to Mind the Kids, the ACAMH podcast where research meets real-world practice in child and adolescent mental health. In this episode, 'Anxiety, does the apple fall far from the tree?', Dr. Jane Gilmour and Professor Umar Toseeb explore whether anxiety runs in families, what the latest research says about clinically anxious parents and children's anxiety disorders, and how genetic, environmental, and family factors may shape risk. Joining them is Dr Sigrid Elfström, lead author of a population-based study published in the Journal of Child Psychology and Psychiatry. The conversation also looks at why diagnosis is not destiny, why prevention matters, and how to communicate risk without parent blaming.They discuss whether anxiety can be transmitted through family processes, what the findings mean in practice, and how clinicians and parents can think about risk without assuming it is deterministic.This episode covers: Children's anxiety disorders. Clinically anxious parents. Parent-child mental health. Genetic and environmental influences. Family processes and prevention. Evidence-based child mental health research.Read the paper 'A detailed investigation of anxiety disorders in children of clinically anxious parents: a population-based study' - https://doi.org/10.1111/jcpp.70085Sigrid Elfström, Susanne Wicks, Christina Dalman, Johan ÅhlénFirst published: 04 December 2025 Get a free CPD/CME certificate for listening to this podcast by registering for a FREE ACAMH Learn account at https://bit.ly/4fF4BBWVisit https://www.acamh.orgFacebook and LinkedIn search / ACAMHInstagram https://www.instagram.com/assoc.camhBluesky https://bsky.app/profile/acamh.bsky.socialX https://x.com/acamh

This is the AHRMM Subject Matter Expert Podcast hosted by Justin Poulin. Tune in every month as we speak with Industry Experts to highlight success stories and solutions from the field that advance the healthcare supply chain. And now, Justin Poulin with this month's Expert… Guest: Ginger Sharp, VP & Chief Supply Chain Officer at Legacy Health Topic: Best Practices for Setting the Table Around Services Sourcing Outline: - Services Sourcing - Overview * Why is it important to continuously engage your internal stakeholders? * Clinically integrated supply is fairly well-established, but generally focused on supplies * How services comes into focus with value analysis * What about non-clinical services? - Best practices for engaging those internal stakeholders around services sourcing * Developing Metrics * Setting cadence for evaluating performance * Establishing Supplier Requirements * Ownership - As you have done this in your own organization, how have department leaders responded to your engagement efforts?

This episode is sponsored by Siphox and Calocurb. Siphox Health - Get your convenient test kit from Siphox Health at https://siphoxhealth.com/flipping50 for 20% off at this link. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Resources Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. Why does menopause gut health become a central player in midlife? How does it impact everything from aging and hormones to brain, bone, and immune health? In this episode, our guest shares the science behind the gut microbiome during perimenopause and menopause, why symptoms like bloating and food sensitivities increase, and what women can do to take back control of their menopause gut health. My Guest: Cynthia Thurlow is a globally recognized expert in nutrition & intermittent fasting, highly sought after speaker, and the CEO and founder of Everyday Wellness Project. She's been a nurse practitioner for 20+ years, is a 2x TEDx speaker: her 2nd talk on intermittent fasting has been viewed over 7 million times. She has been featured on ABC, FOX5, KTLA, CW and in Medium and Entrepreneur. Cynthia was recently listed in Yahoo Finance as one of the “21 founders changing the way we do business.” She's also the host of Everyday Wellness Podcast, which was listed as “20 podcasts that will help you grow in 2020”  by Entrepreneur magazine, and in Business Insider “21 podcasts to expand your mind in 2021.” Questions We Answer in This Episode: [00:04:50] What prompted you to write this book about gut health in menopause? [00:08:50] Why was writing this book so much harder than your first? [00:13:10] How does gut health actually impact the way we age? [00:16:50] What's happening in the gut during menopause that causes symptoms? [00:22:10] How important is stool testing versus just guessing with diet and supplements? [00:25:50] Is constipation normal in midlife, and what's really causing it? [00:28:20] How does intermittent fasting impact gut health and should women still do it? If this episode made you flip your workout routine — share it!

This episode is sponsored by Siphox and Calocurb. Siphox Health - Get your convenient test kit from Siphox Health at https://siphoxhealth.com/flipping50 for 20% off at this link. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Connect with Flipping 50: Facebook Group - Flipping50 Insiders Instagram - @Flipping50TV YouTube - @Flipping50TV More Episodes - Flipping 50 The Stronger Way Other Episodes You Might Like: Previous Episode - Motivation to Move for Longevity: One Doctor's Message Next Episode - The Menopause Gut: Hidden Reasons Symptoms Happen Exercise Won't Fix More Like This - Your Follow-Up Questions on Heavy vs Light Lifting After 50 — Answered With Science Resources: Join Flipping 50 Menopause Fitness Specialist® to become a coach! Know how to design workouts that honor and accommodate the physiology of menopause, physiology of exercise and honor injuries, endocrine status … all within your scope of practice, and attract lucrative clients while becoming an authority. Be a GLP-1 Fitness Specialist with continuing education on GLP-1 medications so your client lose fat without losing muscle, strength, or metabolic health. Build more relevance, more authority, and more opportunity with two of the fastest-growing areas in fitness. Use the Smart Scale in Debra's Favorite Things! Tracking body composition is more important than scale weight. Muscle loss on the shot might be the hidden reason your results aren't what you expected. If you're in midlife and considering—or already using—the shot, this episode breaks down what's really happening to your muscle, metabolism, and strength. We're unpacking the science behind weight loss versus fat loss, and why the scale isn't telling the full story. More importantly, you'll learn what you can do right now to protect your muscle and stay strong through menopause and beyond. Muscle loss on the shot isn't just a possibility—it's a risk you can absolutely control with the right strategy. If this episode made you flip your workout routine — share it!

From Discovery to Delivery: Charting Progress in Gynecologic Oncology, hosted by Ursula A. Matulonis, MD, brings expert insights into the most recent breakthroughs, evolving standards, and emerging therapies across gynecologic cancers. Dr Matulonis is chief of the Division of Gynecologic Oncology and the Brock-Wilcon Family Chair at the Dana-Farber Cancer Institute, as well as a professor of medicine at Harvard Medical School, both in Boston, Massachusetts. In this episode, Dr Matulonis was joined by Elizabeth H. Stover, MD, PhD, a physician at Dana-Farber Cancer Institute and an assistant professor of medicine at Harvard Medical School. Together, they explored the biology and therapeutic relevance of the RAS/MAP kinase pathway in gynecologic cancers. Dr Stover began by explaining that the RAS/MAP kinase pathway is a well-established oncogenic signaling cascade that regulates cancer cell proliferation, survival, and invasion. Advances in drug development are now making it possible to target multiple points along this pathway, including RAS itself, once considered “undruggable.”Drs Matulonis and Stover emphasized that RAS/MAP kinase pathway alterations are relatively common across gynecologic malignancies, occurring in at least 20% of cases overall. Certain disease subtypes have particularly high prevalence, including low-grade serous ovarian cancer, mucinous ovarian cancer, and subsets of endometrial and cervical cancers. Clinically, activation of this pathway is generally associated with more aggressive disease and reduced sensitivity to conventional chemotherapy, although nuances exist. The conversation also explored emerging therapeutic strategies targeting this pathway. Early developmental success with MEK inhibitors—such as trametinib (Mekinist), selumetinib (Koselugo), and binimetinib (Mektovi)—has translated to meaningful clinical benefit, particularly in low-grade serous ovarian cancer. More recently, combination approaches have shown promise, including the dual RAF/MEK inhibitor avutometinib paired with the FAK inhibitor defactinib (Avmapki Fakzynja Co-pack). This combination addresses adaptive resistance mechanisms and has generated improved response rates and disease control, leading to its May 2025 FDA approval in this setting.Looking ahead, Dr Stover highlighted the development of direct RAS inhibitors as one of the most exciting advances in oncology. Dr Stover concluded by outlining key areas of ongoing research, including understanding differential sensitivity across tumor subtypes, identifying mechanisms of resistance, and optimizing combination strategies. 

Inspire, Empower & Educate with Amber Lee (@amberleematchmaker) where they share their biggest lessons learned and words of wisdom from being clinically dead to building a thriving business!   Find out more about them at Website: https://selectdatesociety.com/ LinkedIn: https://www.linkedin.com/in/amber-lee-matchmaker/ Join the FREE Facebook group for The Michael Brian Show at https://www.facebook.com/groups/themichaelbrianshow   Follow Mike on Facebook Instagram & X

This episode is sponsored by Calocurb and Flipping 50 Menopause Fitness Specialist. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Flipping 50 Menopause Fitness Specialist.- Become a health & fitness coach who finally speaks midlife women's language. Learn how to design workouts that balance hormones that actually get results for women in menopause. Other Episodes You Might Like: Previous Episode - What Male Partners Don't Know About Menopause (and need to) More Like This - Finding Exercise Motivation After Menopause Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Join Flipping 50 Menopause Fitness Specialist® to become a coach! Flipping 50 Women's Retreats are each designed to challenge and stretch you. We challenge your fitness, your thoughts about aging, and menopause. We educate about hormones through exercise, nutrition and sleep choices.  We always try to find motivation to move. Truth is if we don't fix this issue, we're not going to fix sarcopenia, obesity, and osteoporosis or Alzheimer's.  This conversation dives into the science of motivation, the difference between exercise vs. daily movement, and why healthy longevity (healthspan) matters more than simply living longer. You'll also hear how to build sustainable habits, avoid burnout, and find movement you actually enjoy—because consistency is the real goal. Movement—not just exercise—is the most powerful “medicine” for longevity. Despite decades of evidence, most people still struggle to stay active—not because they lack knowledge, but because they lack motivation to move. My Guest: Jordan D. Metzl, MD is an internationally recognized sports medicine physician, researcher, bestselling author, and fitness instructor who practices at Hospital for Special Surgery in New York City, the world's premier orthopedic hospital.  Dr. Metzl is a 40-time marathoner and 15-time Ironman finisher. He created the Ironstrength Workout, a functional fitness program for improved performance and injury prevention that has been performed by more than 1 million people. An elite athlete himself, he practices what he preaches.  Questions We Answer in This Episode: You've recently written a new book. You're published in AARP, so let's start with your interest in getting the world to move Why did you write PUSH and how does it reflect the different parts of your career? Why did you choose the title PUSH and why is this concept connected to healthy longevity? Why aren't people comfortable pushing themselves? Can we extend our lifespan? What does science tell us about longevity? Is the financial investment in “longevity” worth the spend? Who is the intended audience for PUSH? If this episode made you flip your workout routine — share it!

Send us Fan MailPaper Discussed in this Episode:Spatial omics and AI for clinically actionable cancer biomarkers. Reitsam NG. PLoS Med 2026; 23(4): e1005049.Episode Summary: In this deep dive, we explore how artificial intelligence and spatial omics are fundamentally rewriting the rules of cancer diagnostics. We break down a 2026 editorial that challenges a deceptively simple question driving modern oncology: Is a tumor "positive" or "negative" for a biomarker? As targeted cancer therapies evolve, this binary thinking is failing us. We discuss why mapping where and how much of a therapeutic target exists is crucial, and how AI is stepping in to solve the reproducibility issues human pathologists face when making borderline diagnostic calls.In This Episode, We Cover:• The Illusion of "Positive" vs. "Negative": Why the basic premise of modern cancer therapies—like antibody-drug conjugates (ADCs)—often falls apart in reality when we ignore the spatial heterogeneity of a tumor.• The Power of Computational Pathology: How AI is transforming subjective, qualitative estimates into continuous, reproducible data, scaling the quantification of complex biomarkers like PD-L1 and TROP2.• "Virtual" Proteomics: The fascinating concept of using AI models to infer high-dimensional spatial information and immune maps directly from standard, routine H&E stained slides.• The HER2 Bottleneck: A real-world look at the breast cancer drug T-DXd, which now demands pathologists distinguish between "HER2-low" and "HER2-ultralow". While human agreement drops below 70% at these fuzzy decision boundaries, AI steps up with a staggering ~97% sensitivity.• Three Shifts for the Future: Why clinical trials and routines must adopt continuous measures (like percentage of expressing cells), demand longitudinal repeat testing at disease progression, and utilize adaptive trial platforms.• Bridging the Gap to Reality: The massive hurdles preventing widespread adoption—such as equipment costs exceeding $250,000 and massive data storage needs. We discuss why a hybrid workflow that bolsters routine pathology with deployable AI is the best path forward to prevent widening global health disparities.Key Takeaway: The future of precision oncology isn't just about finding new drug targets; it's about fundamentally changing how we measure them. By moving away from rigid binary thresholds and using AI to map the continuous, spatial reality of tumors, we can unlock the true potential of targeted therapies. However, achieving this diagnostic ecosystem requires overcoming significant financial and systemic hurdles—such as updating reimbursement pathways and proficiency testing—to ensure these life-saving insights are accessible across all healthcare settings.Support the showGet the "Digital Pathology 101" FREE E-book and join us!

What is testosterone? A hormone ‘anabolic steroid' produced by the testes and ovaries It's important for energy, libido, muscle mass, and bone health It's becoming more common – being marketed on social media as “anti-ageing” or performance-enhancing When is testosterone use appropriate? It's intended for replacement therapy, not body enhancement Clinically confirmed low testosterone in males, gender-affirming therapy, low libido around female menopause Consistent symptoms (fatigue, low libido, reduced muscle mass) and repeated low blood levels It should be prescribed and monitored by a doctor Where does misuse occur? Anti-ageing and wellness Promoted for tiredness, weight gain, low energy It's often labelled “Low T” or “male menopause” Normal ageing is medicalised – most men don't meet treatment criteria Bodybuilding and athletic performance Used at high doses to increase muscle and strength Often involves “stacking” multiple anabolic steroids Banned by organisations such as the World Anti-Doping Agency Supplements and online products Marketed as “testosterone boosters” or “Super T” Often unregulated, lack evidence, and may contain harmful substances What are the risks of misuse? Excessive dosing can heighten the risk of heart disease and strokes (via thickened blood), and cause breast enlargement and hair loss in men In women, it can result in a deepened voice and excess hair growth (which may be irreversible) Mood changes, including anxiety It can mask underlying conditions such as depression or thyroid disease Key points Testosterone has a clear medical role. Its benefits are often overstated, while misuse carries significant risk. LISTEN ABOVE See omnystudio.com/listener for privacy information.

This episode is sponsored by Timeline, Siphox and Calocurb. Timeline - Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $99, with the exact same science and formula. And my listeners can still get 20% off when you go to https://timeline.com/FLIPPING50SHOW  Siphox Health - Get your convenient test kit from Siphox Health at https://siphoxhealth.com/flipping50 for 20% off at this link. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting. Get 10% off when you use this link https://www.flippingfifty.com/calocurb Other Episodes You Might Like: Previous Episode - Stop the Confusion: Turn Midlife Muscle Strength Into Personal Power Next Episode - Motivation to Move for Longevity: One Doctor's Message  More Like This - Love Relationships and The Health & Hormone Connection Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb There is a massive gap in understanding menopause from a male partner's perspective—and why it's causing unnecessary confusion, conflict, and disconnection in relationships. Where to start? What they don't know about menopause might kill them? Or us?  In this episode I am joined by the author of the recently published book by a male, for males, but also valuable to women about navigating menopause with partners.  Instead of focusing only on biology, this conversation dives into what really matters:

If you've struggled with overeating, it's not just about discipline. It's about biology, environment, and hormones.   And for the first time, we have tools that directly address those systems.   Here's a strict, evidence-based breakdown of the negative side effects of GLP medications from: 1. Peer-reviewed clinical trials (PubMed / NEJM / meta-analyses) 2. What is (and is not) documented from Dr. Amin Hedayat   Follow us on IG @preplifepodcast @glamgirlbikini @amyehinger @leemarie183   Watch on YouTube: Glam Girl Bikini   Join the team: https://www.glamgirlbikini.com/get-started/    1st Phorm Supplements we use: https://1stphorm.com/?a_aid=glamgirlbikini 

This episode is sponsored by Siphox and Calocurb. Siphox Health - Get your convenient test kit from Siphox Health at https://siphoxhealth.com/flipping50 for 20% off at this link. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Other Episodes You Might Like: Previous Episode - The Bible for Exercise Guidelines Update: Here's What It Means Next Episode - What Male Partners Don't Know About Menopause (and need to) More Like This: What 40+ Studies Reveal About Rep-Range for Muscle, Strength, and Bone After 50 Why Muscle Growth Feels Harder in Menopause (and What Actually Works) Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Let's redefine what strength truly means—taking midlife muscle strength and turning it into personal power.  From breaking outdated beliefs about lifting and “bulk,” to understanding how muscle becomes your lifelong independence insurance, this conversation reframes strength as both physical power and personal transformation. We answer questions like human behaviour, creating change, defining success on your own terms and so much more.  If you're suffering from decision-making fatigue, information filtering, or feeling a little isolated, frustrated or confused this is your episode. We're turning midlife muscle strength into personal power! My Guest: Cori Lefkowith is the founder of Redefining Strength and the author of The STRONG System, a practical framework designed to help women build sustainable strength, nutrition, and lifestyle habits that support real life. With over a decade of coaching experience, Cori helps women, especially in midlife, break free from burnout, diet culture, and all-or-nothing health thinking by shifting the focus from intensity and willpower to consistency and systems. Her programs and educational content have been featured in outlets including Women's Health, SELF, Nike, Prevention, MSN, Well+Good, MindBodyGreen, LIVESTRONG, and The Guardian. Questions We Answer in This Episode: Why are women still afraid of getting bulky from lifting weights? Can strength training be about more than just weight loss? Why are we stuck in a survival mindset instead of thriving? How do women handle pressure to be everything to everyone? How do you know what fitness advice is actually right for you? Why is asking ‘why' so important in changing habits? Why is muscle so critical for independence and longevity in midlife? If this episode made you flip your workout routine — share it!

For The Other Side NDE Videos Visit ️ youtube.com/@TheOtherSideNDEYT Purchase our book on Amazon The Other Side: Stories From the Afterlife https://a.co/d/23Bbbsa For years, Bob Proctor had an eerie feeling that something life-changing was coming. Then during a routine meeting, a sudden rupture in his aorta left him bleeding internally and rushed into emergency surgery. In that moment between life and death, he says he found himself leaving a warm, familiar place where everything made sense—before being pulled back into his body and a second chance at life. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This episode is sponsored by Cozy Earth and Calocurb. Cozy Earth - Discover how care in every detail transforms simple routines into moments of true comfort and ease. Head to cozyearth.com and use my code Flipping50 for up to 20% off. Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Connect with Flipping 50: Facebook Group - Flipping50 Insiders Instagram - @Flipping50TV YouTube - @Flipping50TV More Episodes - Flipping 50 The Stronger Way Other Episodes You Might Like: Previous Episode - Natural Appetite Control Without or After the Shot - What is Calocurb? Next Episode - Stop the Confusion: Turn Midlife Muscle Strength Into Personal Power More Like This - Your Follow-Up Questions on Heavy vs Light Lifting After 50 — Answered With Science Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. What does the latest exercise guidelines update really mean for you? Good news… it just got simpler! The new guidelines show what midlife women need most—less complexity, more consistency, and real results for metabolic health. And the biggest shift? Resistance training is no longer optional—but it doesn't have to be complicated to work. In this episode, you'll learn exactly what the exercise guidelines update means for your workouts. If this episode made you flip your workout routine — share it!

This episode is sponsored by Timeline and Calocurb. Timeline - Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $99, with the exact same science and formula. And my listeners can still get 20% off when you go to https://timeline.com/FLIPPING50SHOW  Calocurb - Feel full faster with Calocurb! Clinically proven, natural hunger control – prescription free, affordable, and fast acting.Get 10% off when you use this link https://www.flippingfifty.com/calocurb Other Episodes You Might Like: Previous Episode - Navigating Unexpected Health Challenges in Midlife Next Episode - The Bible for Exercise Guidelines Update: Here's What It Means More Like This - GLP-1 Medications for Weight Loss: A 42-Year Fitness Professional's Honest Take Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. The food noise is real.  If you're looking for natural appetite control without the shot, tapering off the shot, or otherwise this episode is for you. If you simply want a better understanding of appetite, craving control, and calming urges to do things you know don't serve you, stay with me.  This episode dives into natural appetite control with clinical research, and real-world application—especially for women navigating midlife, menopause, and weight management. My Guest: Sarah Kennedy is the Founder and CEO of Calocurb Ltd. Calocurb, a revolutionary weight management product, was commercialized after 15 years and $30 million of New Zealand Government backed science. The company currently sells in five international markets and continues to grow rapidly through channels and geographies. Prior to joining Fonterra in 2011 she had more than 20 years' experience in dietary and animal nutrition. Questions We Answer in This Episode: [00:05:47] How was Calocurb developed and where did the idea originate? [00:12:18] How should someone use Calocurb during stressful or high-trigger times like holidays? [00:14:22] What can women expect when coming off GLP-1 medications and can appetite hormones be restored? [00:18:41] Should women try a natural alternative like Calocurb before using GLP-1 medications? [00:20:47] What are the side effects of Calocurb compared to GLP-1 medications? [00:22:47] Do you need a prescription for Calocurb and what is it made of [00:26:16] What is the difference between hunger and cravings and why does it matter?

Host Lamont Gates interviews near-death experiencer Patrick McCollum, who describes dying for about seven and a half minutes after a 1965 motorcycle crash at age 15 and entering darkness, a growing point of light, and a tunnel with subtle sounds before hearing a voice ask “are you ready.” He recounts grasping a hand through a rainbow-like “bubble” portal, feeling profound peace, hearing the voice identify as God, experiencing a rapid life review, and then seeing God as a luminous woman who warned that returning would bring pain and asked him to serve. After being revived in the street and later writing The Sacred Path, McCollum says the experience reshaped his beliefs into an interfaith spirituality, removed his fear of death, and fueled decades of activism, including peacemaking, women's spirituality work, and a current effort to unite indigenous leaders to protect the Amazon, featured in the documentary The Man Who Saves the World.

1. Help us understand the claim of CIBC being the third generation. 2. What is the tone in which you want to address this question? 3. What are things David Powlison did to help you in addressing topics like this? 4. What are the distinctives you are seeing within CIBC? 5. What are your concerns with CIBC and how are you evaluating their approach? 6. What is the difference of epistomology in CIBC counseling? 7. What should the next generation of biblical counselors look like? Click here to sign up for one of our CDT's!

Selecting the right healthcare team is critical on our journey's to motherhood especially after loss or infertility diagnosis. In today's episode, Dr. Eboni January a physician, author, and maternal health expert shares her journey dedicated to helping women reclaim power over their bodies and their stories. We discuss the maternal health crisis and why its critical that Black women chose healthcare providers who listen to you, support you, and make you feel seen clinically and holistically.  Dr. Eboni's mission is to educate, empower, and equip women to navigate every stage of their reproductive and maternal journey with confidence and care. We discuss the importance of listening to women, to centering their voices, and to make sure they feel seen and supported... not just clinically, but holistically. In her book, Empowered Motherhood, Dr. Eboni discusses her personal journey being a resource for other women navigating theirs motherhood journey. The book is about taking back ownership of your body, your health, and your story. Become a Sisters in Loss Birth Bereavement, and Postpartum Doula Here Book Recommendations and Links Below You can shop my Amazon Store or  ​Bookshop.org for the Book Recommendations You can follow Sisters in Loss on Social Join our Black Moms in Loss Online Weekly Grief Support Group Join the Sisters in Loss Online Community Sisters in Loss TV Youtube Channel Sisters in Loss Instagram Sisters in Loss Facebook  

A recent False Claims Act case is raising an important question for CDI professionals: what if the diagnosis is clinically valid, but the process behind it is challenged? During the next live edition of the popular Talk Ten Tuesdays podcast, Dr. Robert Oubre, director of CDI and UM at St. Tammany Health System, will report on a motion for summary judgement on a case (Smith vs Mercy Health) on how malnutrition documentation and electronic medical record (EMR) workflows came under scrutiny. Dr. Oubre will also discuss the role of AHIMA guidance and the importance of compliance oversight. This is a must listen for CDI, coding, and compliance leaders.The popular Internet broadcast will also feature these additional instantly recognizable panelists, who will report more news during their segments:·      POV: Penny Jefferson, Manager of Coding & Clinical Documentation Integrity Services for the University of Davis Medical Center, will share her point of view during the broadcast.·      CDI Report: Cheryl Ericson will provide an update on clinical documentation integrity (CDI).·      The Coding Report: Christine Geiger will report on the latest coding news.·      News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk.

During his NDE, David experienced leaving his body and going to a heavenly place. "It was like walking from one room to another."In this powerful episode, David Cooke shares a life-altering near-death experience (NDE) he had at just seven years old after falling 75 feet into a canyon.Clinically lifeless and placed in a coma for eight days, David recounts vivid out-of-body experiences, including watching doctors work on him, floating above the hospital, and entering what he describes as a heavenly realm.From his NDE, he describes overwhelming peace, weightlessness, and unconditional love—feelings far beyond anything experienced in the physical world. At a gate guarded by an angelic figure, David was told it was not his time and that he still had a purpose on Earth.Despite wanting to stay, he returned to his body—regaining consciousness against overwhelming medical odds.Now decades later, David reflects on how his NDE shaped his faith, eliminated his fear of death, and gave him a deep sense of purpose and peace about what lies beyond this life.Video Version of This EpisodeRoundTripDeath.comDonate to this podcast: https://www.roundtripdeath.com/support/eric@roundtripdeath.com

This week Clint speaks with Dr. Shawn McNeil & Dr. Donard.  In this conversation they explore the latest research and clinical practices in psychiatry, focusing on schizophrenia, genetic testing, early detection, and the impact of AI on mental health.    Dr. Shawn McNeil hosts an Apple podcast, "Addiction Medicine: Beyond the Abstract" Addiction Medicine: Beyond the Abstract - Podcast - Apple Podcasts. A quarterly, interactive addiction journal club was discussed, paired with presentation Dr. McNeil discusses on his podcast. https://podcasts.apple.com/us/podcast/addiction-medicine-beyond-the-abstract/id1806152019   Biography Dr. Shawn McNeil is a physician and researcher at LSU Health Shreveport. He is a Clinical Assistant Professor in the Department of Psychiatry and Behavioral Medicine and serves as Program Director of the Psychiatry Residency Program and Director of Neuroinformatics Research. He is a diplomate of the American Board of Psychiatry & Neurology and is board-certified in General Psychiatry and Child & Adolescent Psychiatry. He completed his Psychiatry residency at LSU Health Shreveport and is a recipient of the Resident Recognition Award from the American Psychiatric Association (APA). He also completed his fellowship in Child & Adolescent Psychiatry at LSU Health, serving as chief resident of the program.   Clinically, Dr. McNeil practices at Louisiana Behavioral Health where he serves as Chief Medical Officer. He also supervises residents at the Ochsner LSU Health Ambulatory Care Center. His primary research is clinical in nature. He is Principal Investigator on a clinical trial (Apathy in Schizophrenia, Intra-Cellular Therapies, Inc.) at the LSU Health Psychiatry Research Clinic which is investigating the use of Lumateperone on motivation in patients with psychotic disorders. He previously worked on the Blüm Autism Study (sponsored by Curemark) and the Tapestry Autism Study (sponsored by Axial Therapeutics). He is also the Director of Clinical Research for the Louisiana Addiction Research Center.   Dr. McNeil serves as President of the Louisiana Psychiatric Medical Association (LPMA). He is on the editorial board of the Journal of Addiction Medicine (JAM) and is host of their podcast "Addiction Medicine: Beyond the Abstract". He is a 2018 recipient of the ASAM's Ruth Fox Memorial Endowment Scholarship. He has also served on the editorial board of the APA's American Journal of Psychiatry Resident's Journal and he has been recognized as a Fellow of the APA.   Dr. McNeil was previously a staff physician at the Overton Brooks VA Medical Center and treated veterans in the Post-Traumatic Stress Disorder Clinic. He continues to proudly serve as a Deputy Coroner of Caddo Parish, Louisiana.     Donard Dwyer, PhD Professor of Psychiatry and Behavioral Medicine   Biography Donard Dwyer received his BS degree in Psychology from Tulane University, a Master's degree in education (MEd) from the University of Rochester and his PhD from the University of Alabama at Birmingham (UAB). In addition, to holding positions as a Research Scientist at the Max-Planck Society laboratories in Würzburg, Germany and Director of Immunology at a Cambridge biotechnology company, Dr. Dwyer has spent 32 years in academic research at UAB and LSU Health Shreveport. He is currently professor of Psychiatry and Pharmacology, Toxicology and Neuroscience at LSU Health Shreveport. In addition, he is Vice-Chair for Research in the Department of Psychiatry.   His research interests range broadly from the evolution of protein ligand-receptor interactions, the electronic properties of amino acids and regulation of glucose transport in neurons to behavioral genetics of motivation and movement in C. elegans and the genetic basis for schizophrenia and neuropsychiatric disorders. He is currently focused on the role of insulin signaling pathways in regulation of motivation in “suicidal” worms and characterization of the genetic architecture of schizophrenia with mathematical approaches. Finally, his laboratory is searching for drugs that produce neuroenhancement in cultured neurons as potential treatments for an array of neuropsychiatric conditions.     Medical Trial: https://www.lsuhs.edu/departments/school-of-medicine/psychiatry-and-behavioral-medicine/research   Chapters 00:00 Introduction to the Podcast and Guests 02:27 Overview of Schizophrenia and Motivation Challenges 04:23 The New Drug Adalumid Teparone and Its Potential 07:50 Understanding Schizophrenia: Causes and Risk Factors 12:04 Genetics of Schizophrenia: Myths and Realities 16:20 Enrolling Patients in Clinical Trials 20:49 Genetic Testing and Personalized Medicine in Psychiatry 25:54 Early Signs of Psychosis in Children 30:50 Supporting Families and Community Resources 40:04 The Role of AI in Future Psychiatry 52:17 AI and the Risks of Artificial Relationships 56:35 Conclusion: Hope and the Future of Mental Health Care

Contact us and share your opinionBoost your triage skills with our dynamic 5-session live webinar course, tailored for primary care clinicians. Led by Dr. Gandalf and Dr. Ed Pooley, this comprehensive training covers all facets of remote patient triage—digital, on-call, and more. Gain practical knowledge, exclusive tips, and direct access to our experts through open Q&A sessions. Elevate your ability to manage primary care challenges effec Join Dr Mike as he shares how to get started and fly using EMIS to make your life easier with this clinical systembit.ly/EMIScourse

Lexi Johnson built her platform long before she ever stepped onto a start line. What started as at-home workouts during COVID turned into a massive online and in-person community. Now she's taking that base into competition, with clear strengths and a lot of room to grow. Then there's ErgShoot, a new format trying to carve out its own lane. It blends ergs with precision shooting, backed by real tech and early traction inside CrossFit events. The goal isn't just to be part of the space, but to build something entirely new. Josh van Zeeland is in the middle of a reset. After injury, the focus has shifted from rushing back to building something more durable. He talks through the rehab process, what he's learned from racing at a high level, and how quickly things changed once he broke into the elite side of HYROX. Lexi Johnson – Topics From dental hygienist to fitness entrepreneur during COVID The "Dungem" and building a massive audience through authenticity Personal mission: father's health transformation driving her purpose Community-first growth: events, clients, and real-world engagement HYROX journey: strong stations, Pro transition, and improving running ErgShoot – Topics Origin story: CrossFit gym experiment to new sport concept Biathlon inspiration: combining ergs with precision shooting Early growth: Concept2 support and CrossFit event integrations Sport mechanics: cardio plus accuracy under fatigue Long-term vision: global expansion, affiliates, and standalone events Josh van Zeeland – Topics Rehab mindset shift: slowing down, patience, and long-term performance From rugby and ACL injury to HYROX and endurance racing Rapid progression: Open debut to Pro racing and Worlds performance Race evolution: pacing, sub-60 barrier, and breakthrough results Injury recovery: hamstring surgery and rebuilding the full athlete Today's episode is brought to you by Xendurance. Clinically proven supplements to improve endurance, energy, and lean body mass Guest Links:  Lexi Johnson | Erg Shoot | Josh Van Zeeland Listen on Apple or Spotify Support us through The Cup Of Coffee Follow Hybrid Fitness Media on IG    

In this episode, we are going to take a closer look at Vancomycin, one of the most widely used antibiotics in the hospital setting and a medication that pharmacists frequently monitor. Vancomycin is a glycopeptide antibiotic primarily used to treat serious gram-positive infections, including those caused by Methicillin-resistant Staphylococcus aureus (MRSA). Its mechanism of action involves inhibiting bacterial cell wall synthesis by binding to the D-alanine–D-alanine portion of peptidoglycan precursors, which ultimately prevents the bacteria from forming a stable cell wall. Clinically, vancomycin is commonly used for infections such as bacteremia, endocarditis, osteomyelitis, and severe skin and soft tissue infections when resistant gram-positive organisms are suspected. One of the most important aspects of vancomycin therapy is therapeutic drug monitoring, as maintaining appropriate exposure is critical for both efficacy and safety. Current practice often focuses on achieving target AUC-to-MIC ratios rather than relying solely on trough levels. Pharmacists also play an important role in adjusting doses based on renal function and monitoring for adverse effects. Two key safety concerns with vancomycin are nephrotoxicity and vancomycin infusion-related reactions such as “red man syndrome,” which is characterized by flushing, rash, and hypotension if the medication is infused too rapidly. Throughout this episode, we will review the pharmacology, monitoring parameters, and clinical pearls that healthcare professionals should understand when managing patients receiving vancomycin therapy. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

For The Other Side NDE Videos Visit ️ youtube.com/@TheOtherSideNDEYT Purchase our book on Amazon The Other Side: Stories From the Afterlife https://a.co/d/23Bbbsa Anna Stone spent her life grounded in science, dismissing spiritual ideas as impossible—until a sudden medical crisis caused her to lose nearly half her blood volume and briefly flatline. During that time, she watched doctors work on her body from above and was mysteriously transported to see her children in different locations. She then entered a strange yellow-white space where she perceived herself as a vast awareness and encountered another version of herself who delivered a simple message. Check Out More Of Anna's NDE Near Death Experience:  www.astonetarot.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Seasons of Marriage- Part TwoA Discussion on the Fluctuating Seasons of Marital Intimacy,and How to Best Support our Marriages Spiritually, Emotionally, and Clinically.Join Pamela Klein, LCSW to delve into the Clinical Aspect. 

Stupid News 3-4-2026 6am …How is that guy not clinically insane? …He got 4 years in Prison for stealing Pokémon Cards …Supermarket AI Bot makes customers feel uneasy

Show notes: (0:00) Intro (1:39) Why Alzheimer's is often overdiagnosed (3:25) The breakthrough discovery (8:39) 40-factor checklist (11:47) The impact of social engagement (15:52) The Five Pillars of Brain Health (18:53) What is brain training? (24:39) The best exercise for brain health (27:39) The "silent killer" of the brain (36:14) Mediterranean diet and brain inflammation (41:20) Reducing amyloid plaques (44:40) Most powerful brain foods (48:19) How to become a "Brain Super Ager." (51:44) Outro Who is Dr. Majid Fotuhi?   Dr. Majid Fotuhi is a neurologist, neuroscientist, and professor with over 35 years of experience specializing in brain health, memory, neuroplasticity, and Alzheimer's prevention. He earned his PhD in neuroscience from Johns Hopkins University, completed medical training at Harvard Medical School, and finished his neurology residency at Johns Hopkins, where he now serves as an adjunct professor.   His research has been widely published and cited internationally. Dr. Fotuhi developed a 12-week program that has helped thousands of patients with memory loss, brain fog, concussion, mild cognitive impairment, and early Alzheimer's disease. His work has been featured by major media outlets, including CNN, NBC News, Today, ABC News, The New York Times, The Washington Post, and The Times. Connect with Dr. Majid Website: https://drfotuhi.com/ LinkedIn: https://www.linkedin.com/company/neurogrow-brain-fitness-center/ IG: https://www.instagram.com/dr_fotuhi/ Pre-order the book: https://drfotuhi.com/pre-order/   Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram

New Mikvah.org Podcast! - Seasons of Marriage A Discussion on the Fluctuating Seasons of Marital Intimacy,and How to Best Support our Marriages Spiritually, Emotionally, and Clinically.Join Mrs. Sarah Rayzel Wagner who is a Mikvah.org Certified Kallah Teacher and Educator to delve into the Torah and Hashkafa Perspective. 

Dupes are everywhere in skin care right now, but similar ingredients do not always mean similar performance. In this episode of ASCP Esty Talk, Maggie and Ella break down the real differences between drugstore dupes and professional products and what that means for results, safety, and trust in the treatment room. ASCP Esty Talk with hosts Ella Cressman and Maggie Staszcuk   Produced by Associated Skin Care Professionals (ASCP) for licensed estheticians, ASCP Esty Talk is a weekly podcast, hosted by licensed estheticians, Ella Cressman, ASCP Skin Deep Magazine contributor, and Maggie Staszcuk, ASCP Program Director. We see your passion, innovation, and hard work and are here to support you by providing a platform for networking, advocacy, camaraderie, and education. We aim to inspire you to ask the right questions, find your motivation, and give you the courage to have the professional skin care career you desire.  About Ella Cressman:  Ella Cressman is a licensed esthetician, certified organic formulator, business owner, ingredient junkie, and esthetic cheerleader! As an educator, she enjoys empowering other estheticians and industry professionals to understand skin care from an ingredient standpoint rather than a product-specific view.  In addition to running a skin care practice, Cressman founded a comprehensive consulting group, the HHP Collective, and has consulted for several successful skin care brands.    Connect with Ella Cressman:  Website: www.hhpcollective.com  LinkedIn: linkedin.com/in/ella-cressman-62aa46a    About Maggie Staszcuk:  Maggie Staszcuk serves as the Program Director for ASCP and is the cohost of ASCP Esty Talk podcast. With over 18 years' experience in the esthetics industry, her diverse background includes roles in spa management, spa and med-spa services, and esthetics education. Since becoming a licensed esthetician in 2006, she carries a range of certifications in basic and advanced esthetics. Maggie is dedicated to equipping estheticians with the knowledge and resources they need to thrive in their careers.   Connect with Maggie Staszcuk:  P: 800.789.0411 EXT 1636  E: MStaszcuk@ascpskincare.com    About our Sponsors:   Comfort Zone – The Italian, multi-awarded science-led, longevity-focused skincare trusted by professionals worldwide. Founded by Dr Bollati, a pharmacist, and powered by over 60 in-house chemists and skin care experts. Clinically tested formulations blend clinical precision, regenerative botanicals, and biotechnology research to transform skin with intention. Part of The Davines Group, certified B Corp since 2016.  Website: https://us.comfortzoneskin.com/ Instagram: https://www.instagram.com/comfortzoneskin_official/   Massage Envy is a national franchisor and does not independently own or operate any of the Massage Envy franchised locations nationwide. The Massage Envy franchise network, through its franchise locations, is the leading provider of massage services. Founded in 2002, Massage Envy now has approximately 1,100 franchise locations in 49 states that have together delivered more than 200 million massages and skin care services. Website: www.massageenvy.com/careers/career-areas/esthetician  Facebook: @MassageEnvyCareers LinkedIn: @MassageEnvy   TiZO Mineral Sunscreens set the standard for aesthetic elegance with tinted and non-tinted formulas for use on virtually all skin types and tones. Our name reflects our commitment: TIZO = Titanium dioxide + Zinc Oxides. All TiZO products are reef-friendly and 100% free of chemical sunscreens, dyes, fragrances, gluten, phthalates, and parabens.  TiZO Photoceutical Skincare is the perfect partner to our sunscreens in the fight against photoaging. These silky, elegant products address tone, texture and hydration while helping to prevent further damage. From our flagship TiZO3 Primer/Sunscreen SPF 40 to our gentle Ultra Zinc formulations to our NEW Advanced Vitamin C+E Serum with Bakuchiol, TIZO has the ideal selection of products to Protect, Repair, and Revitalize skin.  Website: https://tizoskin.com/  Facebook: @tizoskin  Pinterest: @tizoskin  Instagram: @tizoskin  YouTube: @tizoskin      About Associated Skin Care Professionals (ASCP):    Associated Skin Care Professionals (ASCP) is the nation's largest association for skin care professionals and your ONLY all-inclusive source for professional liability insurance, education, community, and career support. For estheticians at every stage of the journey, ASCP is your essential partner. Get in touch with us today if you have any questions or would like to join and become an ASCP member.  Connect with ASCP:  Website: www.ascpskincare.com  Email: getconnected@ascpskincare.com  Phone: 800-789-0411  Facebook: facebook.com/ASCPskincare  Instagram: @ascpskincare   

Full article: Associations of Ultrasound-Derived Fat Fraction and MRI PDFF Measurements:  A Prospective Study in Pediatric Patients with Suspected MASLD Do UDFF measurements have a role in children with MASLD? Selima Siala, MD, discusses the AJR article by Kim et al. that explores associations of UDFF measurements obtained under different breathing conditions with PDFF measurements in children with suspected MASLD.

In this episode, Joseph Carr, Vice President of Supply Chain at Akron Children's, discusses how his team is shifting supply chain decision-making back to a clinically integrated, strategic model. He shares lessons from driving standardization, freeing up clinician time for patient care, and balancing innovation, automation, and workforce well-being while supporting the mission of pediatric care.

(00:00) — Curiosity in the halls of Mass General: Her mom's triple‑negative breast cancer and remission shape an early interest in medicine.(02:54) — Choosing a major without a premed major: From biochemistry to discovering neuroscience and why UMass ultimately fit.(06:04) — Double majoring without burning out: Overlap with prereqs, honest advising on dual degrees, and following interests.(09:13) — Make advising work for you: Meeting early, becoming a peer advisor, and hearing hard feedback you don't want to hear.(12:56) — Rethinking gap years: Fears about money give way to growth, responsibility, and better prep for med school.(17:23) — What went wrong on the first MCAT: Cramming, no plan, and taking it during senior year.(19:33) — The retake that worked: Six months, 3 hours a day, weekly full-lengths, and using AAMC practice tests.(22:52) — Lining up letters after graduation: Staying in touch with advisors and professors, and using undergrad resources.(25:34) — Clinical path: EMT to pediatric ER clinical assistant: Building skills during COVID, behavioral health work, and a role that cemented medicine.(32:05) — The application surprise: Not prewriting secondaries—and why she won't skip that again.(33:43) — First interview jitters and prep: Early invites, mock interviews, and centering fit.(35:52) — Eight interview invites: Why authenticity and geography beat obsessing over stats.(40:33) — Toughest interview prompt: Answering “Tell me about yourself” and a bartender curveball.(44:10) — The first acceptance: A full-circle moment at work and calling mom.(45:40) — Final advice to premeds: Keep an open mind—and be kind to yourself.Today's guest traces a clear, practical path from childhood curiosity in the halls of Mass General—while her mom underwent treatment and later entered remission—to a medical school seat built on consistency, flexibility, and honest self-reflection. She shares how starting at UMass in biochemistry, discovering neuroscience, and building an early relationship with her premed advisor shaped smarter decisions—like delaying the MCAT and embracing gap years she once feared.We dive into the first MCAT attempt that fell flat (no schedule, cramming during senior year, few practice tests) and the 15‑point turnaround that followed: six months post‑graduation, three hours a day, AAMC full‑lengths every Thursday, and a real study plan. She details lining up letters before leaving campus, keeping in touch after graduation, and why not prewriting secondaries became her biggest application headache.Clinically, she moved from EMT certification and campus EMS to behavioral health sitting and a clinical assistant role in a pediatric ER—experiences that cemented her desire to practice. Finally, we cover interviews (including a surprise bartender question), eight invites, the first acceptance at work, and her closing advice: keep an open mind—and be kind to yourself.What You'll Learn:- How to build a productive relationship with your premed advisor- A realistic MCAT retake plan: pacing, practice tests, and scheduling- Why gap years and nonclinical jobs can strengthen your application- Finding schools by fit and mission instead of fixating on stats- Timing letters and prewriting secondaries to avoid bottlenecks

Are near-death experiences proof of an afterlife — or just the brain's final fireworks? Michael Regilio goes into the light to find out on Skeptical Sunday!Welcome to Skeptical Sunday, a special edition of The Jordan Harbinger Show where Jordan and a guest break down a topic that you may have never thought about, open things up, and debunk common misconceptions. This time around, we're joined by skeptic, comedian, and podcaster Michael Regilio!Full show notes and resources can be found here: jordanharbinger.com/1263On This Week's Skeptical Sunday:Near-death experiences are real experiences — but that doesn't make them supernatural. NDEs happen to ordinary people during medical crises, and while skeptics question the metaphysical claims, no one disputes the profound personal impact. These aren't grifts or delusions — they're genuine neurological events that often leave people calmer, kinder, and less afraid of death.The "tunnel of light" isn't universal — it's cultural. Western NDEs feature tunnels and beings of light, but Buddhist and Hindu experiencers often describe rivers, bridges, or ancestors. This cultural filtering suggests NDEs are brain-based events shaped by personal beliefs — not visits to a one-size-fits-all afterlife waiting room."Clinically dead" doesn't mean the brain has completely shut down. Proponents argue NDEs prove consciousness survives death because brains were "flatlining" — but neuroscientists note that minimal brain activity can still occur undetected, and memories may be reconstructed after the fact as the brain "reboots."Dying might actually be a psychedelic experience. When the brain faces extreme stress, it releases a cocktail of DMT, endorphins, and dopamine while electrical hyperexcitation fires neurons en masse — creating vivid, dreamlike experiences that may explain the transcendent feelings people report.You don't need a near-death experience to live like you've had one. People who've had NDEs often return less materialistic, more focused on love, and at peace with mortality. The takeaway? You can adopt that perspective right now — prioritize connection over accumulation, presence over panic — without the terrifying trip to death's door.Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!Connect with Michael Regilio at Twitter, Instagram, Threads, Bluesky, and YouTube, and check out War Bar, his new comedy special!And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors: Northwest Registered Agent: Get more at northwestregisteredagent.com/jordanNutrafol: $10 off 1st month: nutrafol.com, code JORDANShopify: 3 months @ $1/month (select plans): shopify.com/jordanApretude: Learn more: Apretude.com or call 1-888-240-0340Homes.com: Find your home: homes.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.