Podcast appearances and mentions of brian mcdonough

Host: Brian P. McDonough, MD, FAAFP Guest: Tara Graff, DO, MS Guest: Surbhi Sidana, MD While BCMA-directed CAR T-cell therapy has changed the treatment landscape for patients with relapsed and refractory (R/R) multiple myeloma, access remains uneven outside academic centers. In this expert-led discussion, Dr. Brian McDonough, Dr. Surbhi Sidana, and Dr. Tara Graff explore real-world barriers to referral and delivery, evolving care models, and the multidisciplinary coordination required to extend CAR T therapy into community practice. Dr. Sidana is an Associate Professor of Medicine, and she leads the Myeloma CAR T and Immunotherapy program at Stanford Medicine. Dr. Graff is the Director of Clinical Research at Mission Cancer + Blood, and she serves on the National CAR T-Cell Advisory Board for Multiple Myeloma.

Host: Brian P. McDonough, MD, FAAFP Guest: Christopher T. Chen, MD What if a simple blood draw could reveal whether a patient is responding to treatment before surgery? That question is at the heart of a study presented at the 2025 ESMO Congress, which investigated neoadjuvant immune checkpoint blockade in mismatch-repair-proficient (MMR-p) colon cancer. In addition to confirming that combination immunotherapy prior to surgery is a safe and feasible approach, the study also found that circulating tumor DNA (ctDNA) levels correlated with both tumor burden and early treatment response. Joining Dr. Brian McDonough to unpack these insights is Dr. Christopher Chen, Assistant Professor in the Division of Oncology in the Department of Medicine at Stanford University School of Medicine.

Host: Brian P. McDonough, MD, FAAFP Guest: Christopher T. Chen, MD What if a simple blood draw could reveal whether a patient is responding to treatment before surgery? That question is at the heart of a study presented at the 2025 ESMO Congress, which investigated neoadjuvant immune checkpoint blockade in mismatch-repair-proficient (MMR-p) colon cancer. In addition to confirming that combination immunotherapy prior to surgery is a safe and feasible approach, the study also found that circulating tumor DNA (ctDNA) levels correlated with both tumor burden and early treatment response. Joining Dr. Brian McDonough to unpack these insights is Dr. Christopher Chen, Assistant Professor in the Division of Oncology in the Department of Medicine at Stanford University School of Medicine.

A one-on-one interview with Main Line Health Chairman and CEO Emeritus

Host: Brian P. McDonough, MD, FAAFP Guest: Matthew Galsky, MD Five years after treatment, the impact of adjuvant nivolumab still holds strong in high-risk muscle invasive urothelial carcinoma. Join Drs. Brian McDonough and Matthew Galsky as they review the CheckMate 274 trial's long-term data, which show sustained disease-free survival and highlight ctDNA's potential as a marker for residual disease. These findings reinforce nivolumab's role in the evolving standard of care and may support more personalized post-surgical strategies. Dr. Galsky is a Professor of Medicine and the Director of Genitourinary Medical Oncology at the Icahn School of Medicine at Mount Sinai in New York.

A look at the intersection of Artificial Intelligence and Healthcare. The Convergence can be found on ReachMD.comDr Brian McDonough is the host of this impactful series

Host: Brian P. McDonough, MD, FAAFP Guest: Phil Ayers, PharmD, BCNSP, FMSHP, FASHP With the potential to reduce infection risk, improve operational efficiency, and enhance safety through standardization, multi-chamber bags are increasingly being used as an alternative to traditional compounded parenteral nutrition. To explore this approach and how it can be implemented in hospital and home care settings, Dr. Brian McDonough speaks with Dr. George Phillip Ayers. He's an Associate Clinical Professor at the University of Mississippi School of Pharmacy as well as the Chief of Clinical Pharmacy Services in the Department of Pharmacy at the Mississippi Baptist Medical Center in Jackson.

Now more than ever physicans and their patients need to communicate. Our individual health and our country's health depends on it.

Host: Brian P. McDonough, MD, FAAFP Guest: Marie Wood, MD Traditional cancer screening has always focused on individual organs, but now, multi-cancer early detection (MCED) tests are changing that paradigm. By analyzing multiple biomarkers through a single blood draw, MCED testing can detect signals from a variety of cancers—many of which currently lack effective screening tools. These multi-biomarker approaches not only outperform single-marker tests, but also demonstrate scientific rigor and clinical utility. Still, challenges remain, including false positives and integration with standard screening protocols. Joining Dr. Brian McDonough to explore the rationale for using a multi-biomarker approach to MCED testing is Dr. Marie Wood, Professor of Medicine at the University of Colorado School of Medicine and Medical Director of the Hereditary Cancer Program at the CU Cancer Center.

Host: Brian P. McDonough, MD, FAAFP Guest: Mylynda Massart, MD, PhD Given its ability to identify universal cancer signals across multiple tumor types, multi-cancer early detection (MCED) testing is emerging as a promising tool to complement traditional, single-cancer screening methods. Joining Dr. Brian McDonough to share practical strategies for introducing MCED testing into clinical workflows and enhancing patient engagement is Dr. Mylynda Massart. Not only is she an Associate Professor at the University of Pittsburgh School of Medicine, but she's also the Founder and Medical Director of the Primary Care Precision Medicine Clinic and Associate Director of Clinical Services for the Institute for Precision Medicine at the University of Pittsburgh Medical Center.

In this powerful and wide-ranging conversation, Patti Brennan sits down with Dr. Brian McDonough—family physician, media voice of medicine in Philadelphia, and deeply curious podcaster—to explore the surprising parallels between financial planning and healthcare. Together, they unpack what it means to thrive in retirement, why strength, balance, and flexibility matter just as much as savings and investments, and how the systems around us—whether in medicine or money—often miss the human element.  You'll hear stories from the front lines of both hospital rooms and boardrooms: how one resident saved a life by trusting their instincts, why patients feel most seen by the nurses, and what Patti's own father did after retiring from IBM to follow his daughter's Olympic dreams. Whether you're 35 or 65, this episode is packed with real-life advice, emotional insight, and reminders that retirement isn't just about numbers—it's about purpose, health, and the relationships that sustain us.

Host: Brian P. McDonough, MD, FAAFP Guest: Hugh S. Taylor, MD Endometriosis care is often delayed due to diagnostic and treatment access challenges—but early recognition and proactive strategies can change that. In this expert-led discussion, Dr. Brian McDonough sits down with Dr. Hugh Taylor to explore how we can clinically diagnose endometriosis without relying on surgery, streamline prior authorizations, and guide patients toward affordable treatment options while empowering patients through advocacy and education. Dr. Taylor is the Anita O'Keeffe Young Professor and Chair of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine.

Host: Brian P. McDonough, MD, FAAFP Guest: Hugh S. Taylor, MD Endometriosis care is often delayed due to diagnostic and treatment access challenges—but early recognition and proactive strategies can change that. In this expert-led discussion, Dr. Brian McDonough sits down with Dr. Hugh Taylor to explore how we can clinically diagnose endometriosis without relying on surgery, streamline prior authorizations, and guide patients toward affordable treatment options while empowering patients through advocacy and education. Dr. Taylor is the Anita O'Keeffe Young Professor and Chair of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine.

When it comes to your health, you should be in control. Trust science and time tested facts and be wary of conspiracy theories. Most important--build a relationship with your physician. Question everything. Remember, your quality of life, and ultimately, your life is dependent on your actions.

A conversation with Lieutenant General Mark Hertling

All you need to know about clickbait in 60 seconds

The Kennedys' New York is a new book which takes readers behind the walls of the apartments and homes where Jackie Kennedy and her children lived. It also explores the lives of JFK Jr. and his mother as adults.

Major study looks at first two years of the pandemic and determines if more deaths were prevented in states that shut down, encouraged masking and vaccines.

Ray Hennessey discusses his new book: "Beyond Sorry: How to Own Up, make Good, and Move Forward After a Crisis". This podcast is a must for anyone who has been damaged by social media or wants to avoid problems. There is also great advice for anyone starting a company.

The 2000 Convention was held in Philadelphia from July 31-August 3.At the time I was medical reporter at the Fox affiliate in Philadelphia and (since we were the local Fox affiliate) we were given a prime position, incredible access and a key role in feeding video/content to the network. There was no reason for me to be at the convention, and I was anticipating an easy week. Early in the convention, former President Gerald R. Ford had a major health issue that led to his hospitalization. I spent the week at The First Union Center (now Wells Fargo Center). This was a time before significant social media and a time before cable networks realized they could get ratings with talking heads.It was the only time I was ever involved covering any aspect of politics. However, I remember the rhetoric was tough and the stakes were high, but there seemed to be a discourse where people could voice opinions and others could voice theirs without vitriol. On the eve of the 2024 political convention season our nation is hurting and a former President came inches from losing his life. Call me naive, but I am hoping our politicians can cut down on the rhetoric and the talking heads in both cable and social media can stop trying to get ratings, followers and cash from stoking the flames of hatred. A quarter of a century ago I had a front row seat---things weren't perfect (democracy is imperfect) but it was civil.

Host: Brian P. McDonough, MD, FAAFP Guest: Betsy O'Donnell, MD Guest: Tomasz Beer, MD, FACP Should a patient get a positive multi-cancer early detection (MCED) test result, there are two diagnostic resolution pathways proposed for localizing and confirming that result. Joining Dr. Brian McDonough to break down those two pathways and how we can optimize our approach to diagnostic resolution are Drs. Betsy O'Donnell and Tom Beer. Dr. O'Donnell is the Director of Early Detection and Prevention of Malignant Conditions at the Dana-Farber Cancer Institute, and Dr. Beer is the Chief Medical Officer for Multi-Cancer Early Detection at Exact Sciences Corporation.

A look at The Persian Wars through the lens of author Dan Lyons

A look at The Inn at Perry Cabin and St Michaels Maryland

Host: Brian P. McDonough, MD, FAAFP Guest: Nima Nabavizadeh, MD Guest: Tomasz Beer, MD, FACP While multi-cancer early detection (MCED) testing has the potential to significantly impact the way we approach cancer screening, it's important to be aware of the risks associated with it, like overdiagnosis. That's why Drs. Nima Nabavizadeh and Tom Beer join Dr. Brian McDonough to discuss the advantages and drawbacks of MCED testing and how we can mitigate the risk of overdiagnosis. Dr. Nabavizadeh is an Associate Professor in the Department of Radiation Medicine in the School of Medicine at OHSU in Portland, Oregon, and Dr. Beer is the Chief Medical Officer for Multi-Cancer Early Detection at Exact Sciences Corporation.

40 % of Medical Practices lost a physician last year due to burnout. Why?

Host: Brian P. McDonough, MD, FAAFP Guest: Frank Diehl, PhD A poster presented at the 2024 American Association for Cancer Research Annual Meeting showcased findings from the ASCEND 2 study, which examined the performance of a multi-cancer early detection (MCED) test design that included methylation and protein biomarkers. The study found that this test design achieved overall sensitivity of 50.9 percent for all cancers at a high specificity of 98.5 percent. Dive further into these results and what they might mean for early cancer detection with Dr. Brian McDonough and Dr. Frank Diehl, Senior Vice President of Multi Cancer Early Detection at Exact Sciences Corporation.

Special Guest: Dr Gerard Criner

76ers center Joel Embiid just scored 50 points despite having Bell's Palsy. What is Bell's palsy, anyway.

Important look at Focal Therapy for Prostate Cancer

Dublin has alot to offer, but this tour reveals some unexpected surprises. Join Daniel Mulhall, recently retired Irish Ambassador to the United States on this virtual tour.

European Historian Richard Overy joins The Dr Brian McDonough Show with groundbreaking new comments about Joseph Stalin. A critical interview for today's troubled times.

Why is 2024 a Leap Year? The little known health risk.

Dr. Claudia Kawas' research has earned the neurologist the highest honor granted by the Alzheimer's Association. In our conversation she shares fascinating information about an Alzheimer's cure and the newest villain in our battle against dementia--It is called LATE.

So you want to live longer? This fascinating interview with Dr Claudia Kawas might have the answers.

There is a new strain of Covid-19 that has taken over in the United States. How do we know this and what does it mean to you?

Almost a quarter of people break their New Years Resolutions in one week! A look at the numbers and advice for success

Legendary Broadcaster Jim Gardner shares his thoughts on the future of local news, cable and the advent of cord cutting. He shares deeply personal insight about his most important story.

Broadcast legend Angelo Cataldi has written a new book called "Loud". He only saw two championships in over 130 Philadelphia sports seasons he covered, but his greatest championship might be his own. We talk about his battle with depression and his hope to help others.

The incredible story of the Indian 841 Motorcycle which has been fully restored and on display at a DuPont mansion

The Story of Sheldon Anderson

Prevention is the key to good health. But for many peopel who live in poverty it is a struggle to pay for even the basic necessities. In today's episode, a look at hygiene poverty and overcoming the stigma of health challenges.

Dr David Ansell joins Dr Brian McDonough and suggests a better way for patient care

Dr Len Gomella talks about detecting prostate cancer in time to treat it effectively.

A new Harvard Business Review report looks at worplace burnout. The information may shock you. Bottom line: changes need to be made.

How do you know if the advice you are getting on the internet is correct? Some tips to help.

The CDC is changing its recommendations regarding measuring covid in communities We could be closer to getting out of the woods.

What do the metrics tell us? Why did some parts of the country do better than others?Without a doubt, modern medicine and science made a big difference. But there was something far more important that doesn't cost anything and has nothing to do with money or power.Dr. Joseph Dieleman from The University of Washington in Seattle is with The Department of Health Metrics.The answer is in the video.

A look at the true history of St Patrick and how St Patrick's Day is celebrated worldwide

Doctor Brian McDonough, clinical professor of family medicine at Temple University, joins Maggie and Perloff to talk more about the incredible & miraculous progress Damar Hamlin has made in his recovery from the cardiac arrest he suffered on Monday night in the Bills-Bengals game.

Doctor Brian McDonough, clinical professor of family medicine at Temple University, joins Maggie and Perloff to talk more about the medical side of Damar Hamlin's cardiac arrest and possible range of outcomes moving forward.