Podcasts about pearls

P2Y12 inhibitors are a cornerstone of antiplatelet therapy in cardiovascular disease. These agents block the P2Y12 receptor on platelets, preventing ADP-mediated activation and reducing platelet aggregation. By inhibiting this amplification pathway, they help prevent arterial thrombosis in conditions such as acute coronary syndrome, percutaneous coronary intervention, stroke, and peripheral artery disease. The most commonly used oral agents include clopidogrel, prasugrel, and ticagrelor, each with important pharmacokinetic and clinical differences that influence agent selection. From a pharmacist's perspective, choosing the right P2Y12 inhibitor requires balancing ischemic benefit with bleeding risk. Clopidogrel requires CYP2C19 activation and is subject to drug interactions and genetic variability. Prasugrel provides more potent inhibition but carries a higher bleeding risk and is contraindicated in patients with prior stroke or TIA. Ticagrelor offers reversible inhibition but comes with unique considerations such as dyspnea and drug interactions via CYP3A4. Understanding these nuances allows pharmacists to optimize dual antiplatelet therapy and improve patient outcomes. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

ASOPRS Website: Click Here In Pearls on Complex Orbital Reconstruction, Dr. Nicole Topilow moderates a dynamic roundtable with Drs. Grant, Tao, and Kikkawa exploring pre-operative planning, timing of acute versus delayed repairs, and key surgical landmarks in orbital fracture management. The panel dives into implant selection, fixation strategies, customization and 3D printing, and how their approaches have evolved over time. Challenging cases such as large floor and medial wall defects, delayed enophthalmos, infected implants, and post-operative complications are discussed with practical, experience-driven insights. The episode concludes with expert take-home pearls to guide surgeons in managing complex orbital reconstructions with confidence and precision.

Furf and Monty are back with another Pulm PEEPs Pearls episode. The topic of today’s discussion is an often discussed, but often misunderstood, test; the methacholine challenge. They’ll review when to utilize this test, how it should be performed, and the appropriate interpretation. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points What the Test Measures Methacholine challenge is a direct bronchial provocation test of airway hyperresponsiveness (AHR), a core physiologic feature of asthma. Anyone will bronchoconstrict at high enough concentrations — the test looks for an abnormal threshold. The key endpoint is the PC20: the methacholine concentration causing a 20% fall in FEV1. Abnormal in adults: PC20 ≤ 8–16 mg/mL Test Performance Meta-analyses: pooled sensitivity ~60%, specificity ~90%. Real-world cohorts: sensitivity 55–62%, specificity 56–100% (varies by population, protocol, and threshold used). Not a standalone yes/no test — best used as part of a broader diagnostic pathway. Where It Fits in the Asthma Workup The test belongs in a stepwise approach: Step 1: Spirometry + bronchodilator response Step 2: Add FeNO and/or peak flow variability (if available) Step 3: If the picture is still unclear → methacholine challenge It is most useful for symptomatic patients with normal spirometry and no bronchodilator reversibility. Given its cost, mild risk, and discomfort, it should not be a first-line test — most asthma diagnoses do not require it. Technique and Medication Prep Technique ERS guidelines favor tidal breathing over deep inspiratory maneuvers. Deep breaths can be bronchoprotective and blunt the response, reducing sensitivity — especially in mild or well-controlled asthma. Medication Washout (to Avoid False Negatives) Medication ClassWashout PeriodShort-acting beta-agonists (SABA)≥ 6 hoursLong-acting beta-agonists (LABA)~24 hoursUltra-long-acting beta-agonists~48 hoursShort-acting anticholinergics (e.g., ipratropium)~12 hoursLong-acting muscarinic antagonists (LAMA, e.g., tiotropium)7 days Inhaled corticosteroids, leukotriene blockers, and antihistamines do not significantly affect the test acutely — continue these. Withdrawing ICS also carries its own risk for asthma patients. Practical tip: Spell out exactly what to hold and when — for both the patient and the PFT lab — at the time the test is ordered. Interpreting Results Negative Test (PC20 > 16 mg/mL) Very high negative predictive value in symptomatic adults. Makes current asthma quite unlikely (assuming proper test conduct). This is the test’s greatest strength: it is an excellent rule-out test. Positive Test (PC20 ≤ 8–16 mg/mL) More nuanced — airway hyperresponsiveness is not unique to asthma. Can be positive in: chronic cough, allergic rhinitis, COPD, and even some healthy asymptomatic individuals. A positive result raises probability but must be interpreted alongside the clinical story, variable respiratory symptoms, peak flow variability, FeNO, and ICS response. Safety and Risks Overall, the test is quite safe; significant adverse effects are rare. Temporary breathing discomfort is expected (bronchoconstriction is being induced). Severe bronchospasm is possible: A trained clinician should be available; SABA inhaler/nebulizer must be immediately on hand; a physician should be reachable in the facility. Contraindications / cautions: Avoid if FEV1 < 70% predicted or < 1–1.5 L (baseline obstruction greatly increases risk). Avoid within 3 months of an acute cardiac event (rare risk of cardiac events with unstable cardiac disease). Five Pearls — Quick Recap What it tests: Methacholine challenge is a direct test of AHR with high specificity but variable sensitivity — it belongs inside a diagnostic pathway, not as a standalone asthma test. When to use it: Most useful for symptomatic patients with normal spirometry and no bronchodilator response, after FeNO and peak flow variability have been considered. Technique and meds matter: Use tidal breathing protocol; respect washout intervals — especially the 7-day LAMA washout and 24–48 hour LABA window — to avoid false negatives. Safety: Generally safe, but can induce significant bronchoconstriction. Have a SABA available and avoid the test in patients with FEV1 < 70% predicted. Interpretation: A negative test (PC20 > 16 mg/mL) strongly argues against current asthma. A positive test raises probability but is not specific — interpret alongside the full clinical picture. References and Further Reading Coates AL, Wanger J, Cockcroft DW, Culver BH; Bronchoprovocation Testing Task Force: Kai-Håkon Carlsen; Diamant Z, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, de Jongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017 May 1;49(5):1601526. doi: 10.1183/13993003.01526-2016. PMID: 28461290. Lee, J., & Song, J. U. (2021). Diagnostic comparison of methacholine and mannitol bronchial challenge tests for identifying bronchial hyperresponsiveness in asthma: a systematic review and meta-analysis. Journal of Asthma, 58(7), 883–891. https://doi.org/10.1080/02770903.2020.1739704 Davis BE, Blais CM, Cockcroft DW. Methacholine challenge testing: comparative pharmacology. J Asthma Allergy. 2018 May 14;11:89-99. doi: 10.2147/JAA.S160607. PMID: 29785128; PMCID: PMC5957064.

In this episode, James Thornton returns to discuss "The Girl Who Cried Pearls" (2025). Not only is this an amazing piece of animation, it is also nominated for Best Animated Short at the upcoming Academy Awards. They discuss the previous work of Clyde Henry Productions out of Montreal, the creative process behind the film, and a little about their own views on the Oscars and making art in general.

 In this episode, I share what has helped sustain my long-term relationship over the past four decades.  I was asked to share my secrets with a large group of physicians.  I preparing for that realized that I have no secrets. I have an approach. Since I started approaching my relationship with intention, it has gotten better than ever. Resentment grows from silent expectations. Shifting from expectation to intention makes more room for connection. What would love do now? guides me as a practical filter for tone, attention, listening, and repair. It's especially useful given our mismatched neurotypes and when our nervous systems are depleted. In this episode, I share The cost of silent expectations and resentment The value of replacing expectations with clear intentions "What would love do now?" as a moment-to-moment practice How nervous system depletion turns neutral moments into conflict Why friendship and fun matter Pearls of Wisdom Clear intentions open doors. Resentment keeps them shut. Love becomes steadier when we treat it as a verb Long-term relationships are built through practice. Protecting your health, and your partner's health protects the relationship Friendship sustains intimacy Reflection questions: What silent expectations are you holding? What intention do you want to bring to your relationship: connection, kindness, honesty, peace, love? When you are depleted, what could help you respond instead of react? How could you treat your partner more like a friend this week—lighter, more generous, more on the same team? Ways to work with me https://www.jessiemahoneymd.com/ https://www.jessiemahoneymd.com/retreats https://www.jessiemahoneymd.com/yoga https://www.jessiemahoneymd.com/jessies-blog Nothing shared in the Healing Medicine Podcast is medical advice.

In this Parshas Terumah review, Rabbi Aryeh Wolbe focuses on the practical meaning of the Tabernacle (Mishkan) command: “Make Me a sanctuary and I will dwell in them” (Exodus 25:8)—not “in it,” but “in them” (the people). God doesn't need a house; the Mishkan is for building intimate closeness between Hashem and the Jewish people. The Temple (and today synagogues/study halls) is a place of relationship, security, and nurturing divine connection—not a distant monument.Key lessons & practical applications:The Mishkan's purpose — God wants to reside within us (V'shachanti b'tocham). The Holy of Holies had two cherubim facing each other (God & Israel); when Jews follow Torah, they face; when not, they turn away. The home/temple is for private, intimate time with God.Gratitude for seeing descendants — Sarah, Rivka, and Rachel never saw grandchildren; Leah likely saw Asenat. Today's privilege of seeing grandchildren/great-grandchildren is enormous—grandparents must influence positively without interfering (e.g., no naming veto; parents alone decide).Naming & prophecy — Parents receive prophetic guidance at birth/bris (alleged Midrash). Adding a second name (e.g., after deceased relative) is common. Spontaneous additions (like Rabbi's son Yehuda-Noach at bris) reflect divine inspiration.Jealousy vs. knowledge of Hashem — First commandment (“Anochi Hashem…”) and last (“Lo tachmod”) connect: coveting denies Hashem's perfect plan for you. Compare only to your own potential.Modern miracles & awe — Technology (smartphones, Neuralink) reveals Hashem's wonders—don't let them become routine. Israeli survival despite missiles is ongoing splitting of the sea.The rabbi urges bold Jewish pride (yarmulke/tzitzit/tefillin in public), relentless self-improvement, and living with awe: see daily yesh me'ayin (creation from nothing) and thank Hashem constantly._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 20, 2026, in Houston, Texas.Released as Podcast on February 22, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Terumah, #Mishkan, #Dwell, #JewishPride, #HashemWithin ★ Support this podcast ★

In this Parshas Terumah review, Rabbi Aryeh Wolbe focuses on the practical meaning of the Tabernacle (Mishkan) command: “Make Me a sanctuary and I will dwell in them” (Exodus 25:8)—not “in it,” but “in them” (the people). God doesn't need a house; the Mishkan is for building intimate closeness between Hashem and the Jewish people. The Temple (and today synagogues/study halls) is a place of relationship, security, and nurturing divine connection—not a distant monument.Key lessons & practical applications:The Mishkan's purpose — God wants to reside within us (V'shachanti b'tocham). The Holy of Holies had two cherubim facing each other (God & Israel); when Jews follow Torah, they face; when not, they turn away. The home/temple is for private, intimate time with God.Gratitude for seeing descendants — Sarah, Rivka, and Rachel never saw grandchildren; Leah likely saw Asenat. Today's privilege of seeing grandchildren/great-grandchildren is enormous—grandparents must influence positively without interfering (e.g., no naming veto; parents alone decide).Naming & prophecy — Parents receive prophetic guidance at birth/bris (alleged Midrash). Adding a second name (e.g., after deceased relative) is common. Spontaneous additions (like Rabbi's son Yehuda-Noach at bris) reflect divine inspiration.Jealousy vs. knowledge of Hashem — First commandment (“Anochi Hashem…”) and last (“Lo tachmod”) connect: coveting denies Hashem's perfect plan for you. Compare only to your own potential.Modern miracles & awe — Technology (smartphones, Neuralink) reveals Hashem's wonders—don't let them become routine. Israeli survival despite missiles is ongoing splitting of the sea.The rabbi urges bold Jewish pride (yarmulke/tzitzit/tefillin in public), relentless self-improvement, and living with awe: see daily yesh me'ayin (creation from nothing) and thank Hashem constantly._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 20, 2026, in Houston, Texas.Released as Podcast on February 22, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Terumah, #Mishkan, #Dwell, #JewishPride, #HashemWithin ★ Support this podcast ★

Episode 79 - Clinical Research Pearls and Pitfalls by AABIP

February 8, 2026 - Sunday PM Service   Welcome to Cumberland Trace Church of Christ. In this episode we focus on the theme of prayer during a singing night, and a short sermon based on Luke 11:1-4 and other passages. Announcements open the episode — information about attendance cards, Pearls and Pizza Pastries review sessions, CYC meetings and fees, and a request for preachers to help at Becton Church of Christ. The service includes congregational singing (including "Sweet Hour of Prayer"), scripture readings, and a message on learning to pray like Jesus. The preacher outlines three practical marks of Jesus's prayer life that listeners are encouraged to develop in their own walk: praying faithfully (making prayer a regular, disciplined practice), praying frankly (being honest in asking for God's will while submitting to God's will), and praying fervently (pouring out passionate, earnest prayer). Passages referenced include Mark 1:35, Luke 11:1-4, Matthew 26:39, Luke 22:44, Hebrews 5:7, Psalm 63, Daniel 6:10, and other scriptures that illustrate prayer in the Bible. Listeners can expect personal application and encouragement to deepen their prayer life, reminders about responding to the gospel (and the role of Jesus in our access to God), and an invitation to seek baptism or prayer support if needed. The episode closes with communal prayer and worship, plus pastoral offers to help anyone who wants to respond to the gospel or receive prayer.   Duration 49:53

Christian Zyp interviews co-creator Chris Lavis about the stop-motion animated film THE GIRL WHO CRIED PEARLS with Maciek Szczerbowski. It is nominated for the BEST ANIMATED SHORT FILM at the 98th Academy Awards ceremony. Watch the short film on Crave in Canada or on the National Film Board website or NFB YouTube channel.TRHE GIRL WHO CRIED PEARLS... In Montreal, at the dawn of the 20th century, a poor boy falls in love with a girl whose sorrow turns into pearls. He sells them to a ruthless pawnbroker, who hungers for more. Tempted by greed, the boy must choose between love and fortune. The choice could damn his soul.From the Oscar-nominated team of Chris Lavis and Maciek Szczerbowski (MADAME TUTLI-PUTLI), this meticulously crafted film is a testament to the magic of stop-motion animation. With handmade puppets, mesmerizing narration by Colm Feore and a haunting score by Patrick Watson, THE GIRL WHO CRIED PEARLS is a timeless parable of desire, deception and the price of innocence.NFB WEBSITE: www.nfb.ca/film/the-girl-who-cried-pearls/FULL FILM: www.youtube.com/watch?v=zanj0zDKfR8INSTAGRAM: @clydehenryproductions

This is an episode of The Specialist, your weekly dose of wonder. In The Specialist, explore the significance and journey of an extraordinary work through the eyes of those that know it best. On today's episode, Frank Everett, Sotheby's Vice Chairman, Jewelry Americas, discusses the string of faux pearls that belonged to the legendary Jacqueline Kennedy Onassis. Estimated at $500-$700, it was the power of provenance that drove them to sell for over $200,000. Frank is largely self-taugh and moved through the major jewelry houses before joining Sotheby's, where his knowledge of the design and history of great period jewels has led him to oversee record-breaking sales. He has his own popular video series - Frank's Files - and a cult following. Further details about the episode subject Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send a textGrief touches every consulting room. In this episode we gently unpick how to support people after loss, using the RCGP framework “A Compassionate Bereavement Response”. Practical language you can use tomorrow, how to recognise prolonged grief disorder (including in children) and when to refer. The overlap with PTSD, and realistic ways we can look after ourselves as clinicians.Then we change gear for an update on NICE's 2024 guideline covering bacterial meningitis and meningococcal disease: the red flag combination that demands 999, when prehospital antibiotics are (and aren't) advised, the easy to miss early signs, and robust safety netting. Press play for compassionate care, sharper suspicions, and help to make the right clinical decisions when under pressure. Useful linksGriefGood Grief Festival (free events, YouTube Channel and curated resources)RCGP framework “A Compassionate Bereavement Response”Bacterial meningitis and meningococcal diseaseMeningitis Now We are currently looking for 4 new clinicians to join the Red Whale team to help us create and curate our educational content. For more information, on the Join Us section of our website. https://www.redwhale.co.uk/join-usSend us your feedback podcast@redwhale.co.uk or send a voice message Sign up to receive Pearls here. Pearls are available for 3 months from publish date. After this, you can get access them plus 100s more articles when you buy a one-day online course from Red Whale OR sign up to Red Whale Unlimited. Find out more here. Follow us: Facebook, Instagram, LinkedInDisclaimer: We make every effort to ensure the information in this podcast is accurate and correct at the date of publication, but it is of necessity of a brief and general nature, and this should not replace your own good clinical judgement, or be regarded as a substitute for taking professional advice in appropriate circumstances. In particular, check drug doses, side-effects and interactions with the British National Formulary. Save insofar as any such liability cannot be excluded at law, we do not accept any liability for loss of any type caused by reliance on the information in this podcast.

In this episode, we explore several important non-statin cholesterol-lowering therapies, focusing on their mechanisms, clinical uses, and practical considerations for patient care. We start with bile acid sequestrants, also known as resins, including cholestyramine, colestipol, and colesevelam. These medications lower LDL cholesterol by binding bile acids in the gut, prompting the liver to use more cholesterol to make new bile acids. They are effective for LDL reduction but may cause gastrointestinal side effects and have drug interaction considerations. Next, we cover niacin (vitamin B3), which can lower LDL and triglycerides while raising HDL cholesterol. While niacin was historically widely used, its role has declined due to flushing, gastrointestinal symptoms, and potential liver toxicity. Omega-3 fatty acids, including icosapent ethyl (EPA), primarily lower triglycerides and are used in patients with severe hypertriglyceridemia to reduce the risk of pancreatitis. Icosapent ethyl is a purified EPA formulation with evidence of cardiovascular benefit in select high-risk patients. Finally, we discuss bempedoic acid, a newer oral agent that inhibits ATP-citrate lyase in the liver. Because it is activated only in the liver, bempedoic acid may be useful for patients with statin-associated muscle symptoms. Common adverse effects include elevated uric acid and mild increases in liver enzymes. This episode highlights how these non-statin agents can be strategically used alone or in combination with other therapies to help patients reach their lipid goals and reduce cardiovascular risk. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Today we are rehashing Younger Season 4, Episode 6: "A Close Shave." Join us as we discuss the "Pearls of Wisdom" launch party, Liza reconnecting with Jay, Diana realizing she just might love Richard and so much more!

00:00 Start3:44:12 What does the Bible say about being transgender?15:46 Is it okay to get tattoo's in the age of grace?23:19 At what age should we teach kids about good and evil?36:20 Is the Roman Catholic church the true church?45:03 Do you recommend the Walk to Emmaus?45:37 Help with a husband that spends too much time on his phone?51:50 Do believers need to keep the commandments to eat of the tree of life?57:24 What would you do differently if you could live your life over?1:00:16 Are believers still judged on their actions?1:05:22 Advice for a young man wanting to get married1:20:43 Papau New Guinea update

Pastor Levi and Lisa talk about the story of the good Samaritan, told by Jesus after a lawyer asked Jesus "Who is my neighbor?," from Luke 10:25-37, including: Jesus flips the question, it' a heart issue and a call to individual action, and Jesus is our Good Samaritan. This is an episode of Pearls & Swine on the Evangel Houghton Podcast from Evangel Community Church, Houghton, Michigan, February 17, 2026.

On the latest Pickaxe and Roll, Ryan Blackburn breaks down what happened over NBA All-Star weekend and how Team USA vs Team World raised some questions about Nikola Jokic, Jamal Murray, and the Denver Nuggets. He also discusses the Social Contract for the All-Star event and what obligations players actually have to the competition. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Upside Down Kingdom | Parables of the Hidden Treasure and Precious Pearls by Napoleon Church of the Nazarene

In this episode of the Pearls of Wisdom Jewelry Podcast, we're joined by Sebastian "SEBAS" Velasquez, Brand Manager of INOX Men's Jewelry, for a high-energy, insight-packed conversation on how men's jewelry can thrive at retail when story, training, and lifestyle align. INOX has built a reputation as the brand for "men who don't like jewelry," delivering bold designs, approachable price points, and immersive storytelling that resonates with a traditionally overlooked customer. From their iconic Man Cave displays to their industrial aesthetic and bro-friendly brand voice, INOX has redefined how men engage with jewelry in-store. Sebastian dives into one of the industry's biggest challenges: the breakdown of enthusiasm between trade shows, store owners, and frontline sales staff. To solve this, INOX is making a major investment in retailer success with the launch of School of Hard INOX, a comprehensive video training series created in partnership with Jewelry Sales Academy. These short, engaging modules go beyond specs and materials, teaching sales teams how to communicate stories, emotion, and identity—because stories sell, and facts just tell. The episode also highlights INOX's expanded 2026 support program, including ready-to-use social media campaigns, event-driven marketing assets, and teaser tools that help retailers build hype before new collections even arrive. Listeners will hear about upcoming product drops, including dozens of new styles, and how INOX aligns with meaningful causes like Movember to connect authentically with today's consumer. If you're a retailer looking to energize your men's jewelry category—or a brand seeking inspiration for full-circle support—this conversation delivers real-world insight, humor, and actionable takeaways. Tune in, get inspired, and discover why INOX continues to stand out in the jewelry industry. Don't miss this episode!   Sponsored By:  INOX Men's Jewelry  - https://www.inox-us.com/ - https://www.instagram.com/inoxjewelry/?hl=en  - https://www.facebook.com/inoxmensjewelry/   

What do you want to be known for?  One thing we want to be known for is this podcast. 300 episodes in, we are committed to offering fresh perspectives and value as healing medicine for our listeners as well as conversations that help to heal the culture of medicine. When we ask the question, "What do we want to be known for?" it becomes a decision-making filter, a boundary-setting tool, and a compass for alignment—helping us lead with love and live closer to our true selves. In this episode, we explore: How "default identities" form in medicine (often unintentionally) The cost of being known for something that no longer, or never fit How to use the question "what I want to be known for" as a values-based filter Pearls of Wisdom Default identities form through repetition, people-pleasing, and conditioning—not always conscious choice. Naming what you don't want to be known for helps refine what matters. Values like authenticity, compassion, and love support intentional leadership. There's no urgency for a perfect answer—clarity can emerge slowly. Reflection Questions What are you currently known for? Did you choose this, or did it just happen? Where does your current identity feel true? Where does it feel heavy or misaligned? What's one small step you can take toward being known for what really matters to you? Resources & Next Steps Read Jessie's blog on this same topic: https://www.jessiemahoneymd.com/jessies-blog/what-do-you-want-to-be-known-for-1?rq=known%20for I fyou want to work on this question, reach out 1:1 coaching or join Jessie for a mindful coaching retreat at Nicasio Creek Farm in 2026. Join Jessie and Ni-Cheng for Connect in Nature at Green Gulch Farm and Zen Center (the only retreat we offer together and an opportunity to bring friends, partners, and colleagues of all genders and professions. Speaking/Workshops: Dr. Mahoney: www.jessiemahoneymd.com/speaking Dr. Liang: www.awakenbreath.org Disclaimer Nothing shared in the Healing Medicine Podcast is medical advice.

Hypertension is one of the most common conditions nurses manage, yet small details can make a big difference in patient outcomes. In this episode, we break down essential hypertension pearls every nurse should know. Whether you're preparing for exams or caring for patients at the bedside, this episode delivers concise, high-yield strategies to help you manage hypertension with confidence and clarity. Your support helps me provide more free resources like this! Consider supporting and getting more amazing pharmacology content! Head on over to meded101.com/nurse

In this Parshas Mishpatim review, Rabbi Aryeh Wolbe explores the practical, common-sense laws (mishpatim) that follow the Ten Commandments—laws that “make sense” (e.g., damages, theft, honesty, fair treatment)—and contrasts them with chukim (statutes with no apparent reason, like the red heifer). He emphasizes that all mitzvot must be fulfilled because they are God's command—not only because we understand them.Key lessons:Mishpatim vs. Chukim — Mishpatim (rational laws) are intuitive (e.g., don't steal, don't murder); chukim defy human logic (King Solomon couldn't understand the red heifer). Yet both are binding—do them because “God said so,” not just because they “feel good.”No compromise in halacha — Halacha never splits the difference (e.g., no “30-foot sukkah” between 20 and 40 feet). Mezuzah on a slant is the only compromise: vertical (one opinion) + horizontal (other) = slant, reminding us that peace in the home requires compromise.Fulfill mitzvot beyond understanding — Even meaningful mitzvot (e.g., Hanukkah candles for history/light) must be done because commanded—not just for emotion or meaning. When the “feeling” fades, the command remains.Parenting parallel — Children must sometimes obey “because I said so” (no explanation)—builds discipline. Same with mitzvot: intellect (chukim) overrides emotion when needed.Mezuzah as reminder — On a slant to symbolize compromise for shalom bayit (peace in the home). Every glance at a mezuzah reminds: do mitzvot for God's sake, even when logic/emotion fails.The rabbi urges: don't rationalize away mitzvot when the reason doesn't resonate—fulfill them with joy and commitment because they are divine commands. Live intentionally: intellect + heart + command = true avodah._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 13, 2026, in Houston, Texas.Released as Podcast on February 13, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Mishpatim ★ Support this podcast ★

In this Parshas Mishpatim review, Rabbi Aryeh Wolbe explores the practical, common-sense laws (mishpatim) that follow the Ten Commandments—laws that “make sense” (e.g., damages, theft, honesty, fair treatment)—and contrasts them with chukim (statutes with no apparent reason, like the red heifer). He emphasizes that all mitzvot must be fulfilled because they are God's command—not only because we understand them.Key lessons:Mishpatim vs. Chukim — Mishpatim (rational laws) are intuitive (e.g., don't steal, don't murder); chukim defy human logic (King Solomon couldn't understand the red heifer). Yet both are binding—do them because “God said so,” not just because they “feel good.”No compromise in halacha — Halacha never splits the difference (e.g., no “30-foot sukkah” between 20 and 40 feet). Mezuzah on a slant is the only compromise: vertical (one opinion) + horizontal (other) = slant, reminding us that peace in the home requires compromise.Fulfill mitzvot beyond understanding — Even meaningful mitzvot (e.g., Hanukkah candles for history/light) must be done because commanded—not just for emotion or meaning. When the “feeling” fades, the command remains.Parenting parallel — Children must sometimes obey “because I said so” (no explanation)—builds discipline. Same with mitzvot: intellect (chukim) overrides emotion when needed.Mezuzah as reminder — On a slant to symbolize compromise for shalom bayit (peace in the home). Every glance at a mezuzah reminds: do mitzvot for God's sake, even when logic/emotion fails.The rabbi urges: don't rationalize away mitzvot when the reason doesn't resonate—fulfill them with joy and commitment because they are divine commands. Live intentionally: intellect + heart + command = true avodah._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 13, 2026, in Houston, Texas.Released as Podcast on February 13, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Mishpatim ★ Support this podcast ★

Send a textFiona and Nik break down the latest evidence on menopause, HRT and cognition so you can feel confident when patients ask, “Should I be worried?”Plus: in our second Pearl in this episode,  practical tips for behaviour change that actually sticks, including how to spot those golden moments and use the STOP IT model to turn advice into action.Tune in for clear answers and real‑world support for primary care.Perfect for anyone in primary care who wants to feel informed, confident and ready for the inevitable “I saw this in the news...” conversation.Useful LinksBritish Menopause Society: Menopause linked to loss of grey matter in the brain, poorer mental health and sleep disturbance We are currently looking for 4 new clinicians to join the Red Whale team to help us create and curate our educational content. For more information, on the Join Us section of our website. https://www.redwhale.co.uk/join-usSend us your feedback podcast@redwhale.co.uk or send a voice message Sign up to receive Pearls here. Pearls are available for 3 months from publish date. After this, you can get access them plus 100s more articles when you buy a one-day online course from Red Whale OR sign up to Red Whale Unlimited. Find out more here. Follow us: Facebook, Instagram, LinkedInDisclaimer: We make every effort to ensure the information in this podcast is accurate and correct at the date of publication, but it is of necessity of a brief and general nature, and this should not replace your own good clinical judgement, or be regarded as a substitute for taking professional advice in appropriate circumstances. In particular, check drug doses, side-effects and interactions with the British National Formulary. Save insofar as any such liability cannot be excluded at law, we do not accept any liability for loss of any type caused by reliance on the information in this podcast.

Event Objectives:Identify preventative strategiesReview common causes of overuse injuries in pediatric sportsClaim CME Credit Here

In this pharmacology podcast episode, we focus on two key non-statin cholesterol-lowering therapies: ezetimibe and PCSK9 inhibitors (Click here to listen to the statin podcast episode). These agents play a role in lipid management, particularly for patients who are unable to reach LDL cholesterol goals with statins alone or who have statin intolerance. Ezetimibe works by inhibiting the absorption of dietary and biliary cholesterol at the brush border of the small intestine. By reducing the amount of cholesterol delivered to the liver, ezetimibe lowers circulating LDL cholesterol by approximately 15 to 25 percent. It is taken orally once daily and is commonly used as add-on therapy to statins in patients with established atherosclerotic cardiovascular disease or high baseline LDL levels. Ezetimibe is generally well tolerated, with a favorable safety profile and minimal systemic exposure, making it an attractive option in older adults and patients with multiple comorbidities. PCSK9 inhibitors, including alirocumab and evolocumab, offer a much more potent LDL-lowering effect. These monoclonal antibodies work by blocking PCSK9, a protein that promotes degradation of LDL receptors in the liver. By preserving LDL receptors, PCSK9 inhibitors enhance clearance of LDL cholesterol from the bloodstream, often reducing LDL levels by 50 to 60 percent. They are administered via subcutaneous injection every two to four weeks and are most commonly used in patients with familial hypercholesterolemia, established cardiovascular disease, or persistently elevated LDL despite maximally tolerated statin and ezetimibe therapy. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Today's Case A 63-year-old male is brought in by ambulance to the emergency room for new onset weakness and confusion. His last known well time was 1 hour before presentation. He was having dinner with his family when suddenly he developed weakness and confusion, and the family called 911. He has a past medical history of type 1 diabetes, hypertension, and a strong family history of cerebral infarctions. He has not had any recent head trauma, major bleeding, strokes, or blood thinners. Today's Reader Ryan O'Connell is a junior biology major at Loyola Marymount University. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. More from Dr. Raj ⁠⁠⁠⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Dr. Raj on Twitter⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Dr. Raj on Instagram⁠⁠⁠⁠⁠⁠ Want more board review content? ⁠⁠⁠⁠⁠⁠USMLE Step 1 Ad-Free Bundle⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Crush Step 1⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Step 2 Secrets⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Beyond the Pearls⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Beyond the Pearls Premium⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠USMLE Step 3 Review⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠MedPrepTGo Step 1 Questions⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠MedPrepTGo Step 2 Questions⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Mike, Debi, Nathan and Ashley Pearl answer questions sent in from viewers:Nathan Pearl - Romans: https://youtu.be/MdJuH7m8lRs?si=JXmCRXozvmrBK7_DTimestamps00:00 Start01:18 Did God create some people for hell?12:20 What do you think of Trump's 'Board of Peace?'14:43 Can single women speak in church?30:25 Is it sinful to allow children to play Minecraft?43:49 What is the difference between the Holy Spirit and the Holy Ghost?47:31 Do departed souls wander the Earth?50:21 Is it wrong to work on Sunday?56:48 Should preachers say 'amen' in their own sermons?1:00:42 What video games does Mike play?

Pastor Levi and Lisa talk about the Sodomites and Lot, from Gen. 19:1-14, including Lot wanted influence without holiness (Genesis 19:1), Lot's urgency shows he knew what Sodom was (Genesis 19:2–3), and a hardened culture doesn't tolerate sin—it demands it (Genesis 19:4–9). This is an episode of Pearls & Swine on the Evangel Houghton Podcast from Evangel Community Church, Houghton, Michigan, February 10, 2026.

A conversation about living through a "fun filter." What does it looks like to let joy, ease, and alignment guide our decisions instead of obligation, striving, or outdated beliefs? A special co-released episode with Dr. Melissa Parsons, fellow retired pediatrician, coach, and kindred spirit.  Together, we reflect on our own transitions out of pediatrics, how we've redefined success, and the freedom that comes when we allow ourselves to change, grow, and choose what lights us up. We also share honest moments about parenting adult children, reimagining purpose, and how sometimes the most meaningful transformations begin when we stop pushing and start listening. If you've been wondering what gets to be "enough," this episode offers a gentler compass. In this episode, we explore: What a "fun filter" is (and what it isn't) Redefining success after leaving a long-held identity Why we don't have to earn rest, joy, or white space How change can be a sign of being fully alive Letting alignment and impact coexist Pearls of Wisdom Choosing what's fun is not frivolous and can be freeing. You don't have to earn rest, white space, or joy. Change doesn't make you flighty because it means you're alive. Fun and impact can coexist. "Enough" isn't a milestone; it's a mindset. Reflection Questions: What currently feels fun, easy, or light in your life? Where might you be holding onto old definitions of "success" or "productivity"? What might open up if you trusted fun as a valid reason to say yes—or no? Resources & Links: Enjoy these Mindful Yoga Classes about Fun Playfulness + Connection + Flow = Fun Mindful Yoga with Jessie Mahoney Breathe in Fun, Lightness, and Love. Exhale Stress and Anxiety. Mindful Yoga to Explore Ease. Coaching: www.jessiemahoneymd.com/coaching Retreats: www.jessiemahoneymd.com/retreats Speaking/Workshops: www.jessiemahoneymd.com/speaking Dr. Melissa Parsons: melissaparsonscoaching.com Listen to Melissa's podcast, Your Favorite You: www.melissaparsonscoaching.com/podcast Melissa Parsons, MD, is a board-certified pediatrician, who practiced in Columbus, Ohio for 22 years, retiring in 2021. She became interested in coaching in 2017, recognizing that she liked her life, but she did not love it, and could not figure out why. Coaching helped her create a life she never dreamed possible. Melissa started her business, Melissa Parsons Coaching, in May 2020, and she has not looked back since, except to help other amazing women learn to love themselves and their lives, too! Melissa hosts a popular podcast called Your Favorite You,. She runs a group coaching program by the same name for small groups of women looking to become their favorite versions of themselves, often by treating themselves as they would a best friend.  Disclaimer: Nothing shared on the Healing Medicine Podcast is medical advice.  

This week’s Pulm PEEPs Pearls episode is all about spontaneous breathing trials (SBTs). SBTs are a standard part of the daily practice in the intensive care unit, but the exact methods vary across ICUs and institutions. Listen in to hear about the most common methods of SBTs, the physiology of each method, and what the evidence says. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points What an SBT is really testing An SBT is a stress test for post-extubation work of breathing, not just a ventilator check. The goal is to balance sensitivity and specificity: Too hard → unnecessary failures and delayed extubation Too easy → false positives and higher risk of reintubation Common SBT modalities and how they compare T-piece No inspiratory support and no PEEP Highest work of breathing Most “physiologic” but often too strict Pressure support (PS) + PEEP (e.g., 5/5 or 8/5) Offsets ETT resistance and provides modest assistance Easier to pass than T-piece CPAP (0/5) No inspiratory help, but provides PEEP to counter ETT resistance Sits between PS and T-piece in difficulty Evidence favors pressure-supported SBTs for most patients Large meta-analysis (~6,000 patients, >40 RCTs): Pressure-supported SBTs increase successful extubation (~7% absolute benefit) No increase in reintubation rates Trials (e.g., FAST trial): Patients pass SBTs earlier Leads to earlier extubation and fewer ventilator-associated risks Bottom line: A 30-minute PS 5/5 SBT is evidence-based and appropriate for most stable ICU patients When a T-piece still makes sense T-piece SBTs are useful when: Cost of reintubation is high Difficult airway Prior failed extubation Pretest probability of success is low Prolonged or difficult weaning Tracheostomy vs extubation decisions Need to mimic physiology without positive pressure In LV dysfunction or pulmonary edema even small amounts PEEP may significantly improve physiology Some centers use a hybrid approach: PS SBT → short confirmatory T-piece before extubation CPAP as a middle ground Rationale: Allows full patient effort while compensating for ETT resistance Evidence: Fewer and smaller trials Possible modest improvement in extubation success No clear mortality or LOS benefit Reasonable option based on patient physiology, institutional protocols, and clinician comfort No single “perfect” SBT mode Across PS, T-piece, CPAP, and newer methods (e.g., high-flow via ETT) there are no consistent differences in mortality or length of stay What matters most: Daily protocolized screening Thoughtful bedside clinical judgment Matching SBT difficulty to patient-specific risk Institutional variation is normal—and acceptable Examples: PS 10/5 in postoperative surgical ICU patients PS 5/0 as an intermediate difficulty option Key question clinicians should ask: What does passing or failing this specific SBT tell me about this patient's likelihood of post-extubation success? Take-home pearls SBTs are stress tests of post-extubation physiology. PS 5/5 for 30 minutes is a strong default for most ICU patients. T-piece trials are valuable when false positives are costly or physiology demands it. CPAP is reasonable but supported by less robust data. Consistency, daily screening, and judgment matter more than the exact mode. References and Further Reading Burns KEA, Khan J, Phoophiboon V, Trivedi V, Gomez-Builes JC, Giammarioli B, Lewis K, Chaudhuri D, Desai K, Friedrich JO. Spontaneous Breathing Trial Techniques for Extubating Adults and Children Who Are Critically Ill: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2024 Feb 5;7(2):e2356794. doi: 10.1001/jamanetworkopen.2023.56794. PMID: 38393729; PMCID: PMC10891471. Burns KEA, Sadeghirad B, Ghadimi M, Khan J, Phoophiboon V, Trivedi V, Gomez Builes C, Giammarioli B, Lewis K, Chaudhuri D, Desai K, Friedrich JO. Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. Crit Care. 2024 Jun 8;28(1):194. doi: 10.1186/s13054-024-04958-4. PMID: 38849936; PMCID: PMC11162018. Subirà C, Hernández G, Vázquez A, Rodríguez-García R, González-Castro A, García C, Rubio O, Ventura L, López A, de la Torre MC, Keough E, Arauzo V, Hermosa C, Sánchez C, Tizón A, Tenza E, Laborda C, Cabañes S, Lacueva V, Del Mar Fernández M, Arnau A, Fernández R. Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA. 2019 Jun 11;321(22):2175-2182. doi: 10.1001/jama.2019.7234. Erratum in: JAMA. 2019 Aug 20;322(7):696. doi: 10.1001/jama.2019.11119. PMID: 31184740; PMCID: PMC6563557. Burns KEA, Wong J, Rizvi L, Lafreniere-Roula M, Thorpe K, Devlin JW, Cook DJ, Seely A, Dodek PM, Tanios M, Piraino T, Gouskos A, Kiedrowski KC, Kay P, Mitchell S, Merner GW, Mayette M, D’Aragon F, Lamontagne F, Rochwerg B, Turgeon A, Sia YT, Charbonney E, Aslanian P, Criner GJ, Hyzy RC, Beitler JR, Kassis EB, Kutsogiannis DJ, Meade MO, Liebler J, Iyer-Kumar S, Tsang J, Cirone R, Shanholtz C, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA. 2024 Dec 3;332(21):1808-1821. doi: 10.1001/jama.2024.20631. PMID: 39382222; PMCID: PMC11581551. Mahul M, Jung B, Galia F, Molinari N, de Jong A, Coisel Y, Vaschetto R, Matecki S, Chanques G, Brochard L, Jaber S. Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients. Crit Care. 2016 Oct 27;20(1):346. doi: 10.1186/s13054-016-1457-4. PMID: 27784322; PMCID: PMC5081985. Yi LJ, Tian X, Chen M, Lei JM, Xiao N, Jiménez-Herrera MF. Comparative Efficacy and Safety of Four Different Spontaneous Breathing Trials for Weaning From Mechanical Ventilation: A Systematic Review and Network Meta-Analysis. Front Med (Lausanne). 2021 Nov 22;8:731196. doi: 10.3389/fmed.2021.731196. PMID: 34881255; PMCID: PMC8647911.​

In today's episode of the Atheist Experience, Justin and Godless Engineer explore the blood-soaked roots of the Bible, challenge the validity of biblical inerrancy, and play a game of "Infallible" to highlight scriptural contradictions! From the ethical horrors of Esther to the "Jesus mode" of logic, the hosts invite believers to defend a deity whose morality seems stuck in a loop of violence and non-consensual interactions.Eric in CA asks about the hosts' deconversion journeys. Justin shares how he continued living his life, even performing weddings, while John describes creating an online persona to avoid family conflict. Is isolation the only way to find peace?C.J. in MA faces believers using "Pearls before Swine" rhetoric. The hosts suggest using 1 Peter 3:15 and Hebrews 6 to flip the script. By putting pressure on the believer, can you expose their fear of debate?Ben from Canada struggles with identity thirty years after losing faith. Justin explains that secularism allows you to choose your own destiny and value. Can realizing that worth is chosen help a person finally find peace?Ben in CT seeks advice for debating his Catholic brother. The hosts suggest the brother's persistence indicates internal doubt. Can using "Mary was raped" and Old Testament facts force him to confront his creed?Sands in AZ argues teaching religion in school exposes kids to diverse views. John warns that nationalists would abuse this to prioritize dogma. Can exposing scriptural contradictions serve as a vaccine against indoctrination?Thank you for joining us this week! We will see you next time!Become a supporter of this podcast: https://www.spreaker.com/podcast/the-atheist-experience--3254896/support.

Ben and Nathan react to Harvard considering A+ grades in response to grade inflation. They discuss how grading practices have changed and what could meaningfully change the system. Also in this episode- Demon students share their January LSAT results- How to choose between a regional school and a top-ranked school- A listener asks about attending a non-ABA accredited law schoolNew York Times Articles by Mark ArsenaultStudy with our Free Plan⁠⁠Download our iOS app⁠Watch Episode 545 on YouTubeCheck out all of our “What's the Deal With” segmentsGet caught up with our ⁠Word of the Week⁠⁠ library0:00 Harvard Adding A+ Grading10:50 January Score Release0:00 Attending a Regional School27:50 Improving Accuracy 42:50 Test D Question — Vor59:24 Pearls v. Turds1:06:20 140s Jail1:14:28 Non-ABA Law School1:24:00 Too Late to Apply?1:31:13 Thank You Email1:36:36 Word of the Week — chiaroscuro

It's Sunday, and as you know, that's when Rich turns his attention to spiritual and personal growth topics, and today he's going to stick to personal growth. He recently ran across a list of advice from a gentleman named Kevn Kelly, who was one of founders of Wired magazine, and who was called "the Most Interesting Man in the World" by podcaster Tim Ferriss. Take a listen, I'm sure you'll find a few things in here--or a few dozen--that will be worth your while.

Peloton reduces its workforce yet again, sparking industry buzz and member reactions.Tunde's Magic Mike ride stirs up some unexpected emotions among the guys.Peloton meets with UK members to address concerns over recent schedule changes.Highlights from the Peloton Instructor Summits—what's happening behind the scenes.Peloton extends special pricing to Canada, with even more people now eligible.Strength+ App officially launches in Canada, expanding Peloton's fitness offerings.Peloton's Senior Vice President & General Manager of Peloton for Business announces their departure.Songs that hit you right in the feels—emotionally triggering tracks discussed.Ben Alldis surprises riders during his INXS-themed ride—what went down?Hannah Corbin featured in Self Magazine—spotlighting her fitness journey and impact.Johanna files for a trademark—what could this mean for Peloton's future?February's Artist Series lineup—what to expect and which rides to bookmark.Tonal hires new coaches—how this could shake up the connected fitness space.Oura extends a hand to Peloton employees affected by recent downsizing.TCO Top 5: Listener-recommended Peloton classes you won't want to miss.This Week at Peloton: A roundup of the week's biggest highlights and updates.TCO Radar: The classes currently trending on The Clip Out's radar.Peloton celebrates Black History Month with special rides and content.Matt Wilpers' Move For Life plans and an exciting new challenge for members.Matt Wilpers and Christian Vande Velde team up for a Valentine's Day ride—don't miss it!TCO has your HiLit resources to keep you informed and inspired.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fibrate derivatives are lipid-lowering medications that primarily target triglycerides rather than LDL cholesterol. Common agents include gemfibrozil, fenofibrate, and fenofibric acid. While their use has declined with the widespread adoption of statins, fibrates remain an important option for patients with severe hypertriglyceridemia, particularly to reduce the risk of acute pancreatitis rather than for routine cardiovascular risk reduction. Fibrates work by activating PPAR-alpha, which increases lipoprotein lipase activity and enhances the clearance of triglyceride-rich lipoproteins. This leads to significant reductions in triglycerides, modest increases in HDL cholesterol, and variable effects on LDL cholesterol. Because they are not strong LDL-lowering agents, fibrates should not replace statins in patients who require LDL reduction, but they can be effective in select clinical scenarios when triglycerides are the primary concern. From a safety standpoint, fibrates are generally well tolerated but require careful monitoring. Common concerns include gastrointestinal side effects, liver enzyme elevations, gallstone risk, and muscle toxicity, especially when combined with statins. Gemfibrozil carries a higher risk of drug interactions, while fenofibrate is usually preferred if combination therapy is necessary. Appropriate patient selection, lab monitoring, and lifestyle counseling are essential to maximize benefit and minimize harm when using fibrate derivatives. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

In this Parshas Yisro review, Rabbi Aryeh Wolbe highlights the unique honor of an entire Torah portion named after Yisro—Moshe's father-in-law and a former spiritual leader of Midian—despite no portion being named for Moshe, Aaron, Abraham, Isaac, Jacob, or Joseph. Yisro heard of the Exodus miracles (plagues, splitting of the sea, manna) and immediately acted: he left everything to join the Jewish people, converting and bringing practical wisdom (organizing judges).The rabbi stresses practical application over storytelling: the Torah is a “manual for living.” Yisro's response teaches that true emunah is knowledge—not blind faith. We know Hashem exists because “Anochi Hashem Elokecha asher hotzeticha me'eretz Mitzrayim” (I am Hashem your God who took you out of Egypt)—personal, witnessed miracles prove it.Key lessons:Don't assimilate to gain favor — The Jews in Egypt kept their names, language, and dress distinct, yet found chen (favor) in Egyptian eyes because Hashem granted it. Pride in authentic Judaism draws divine favor, which then reflects in others' eyes.Jealousy (lo tachmod) opposes knowledge of Hashem — The first commandment (Anochi Hashem) and last (don't covet) connect: coveting others' blessings denies Hashem's perfect design for you. Compare only to your own potential.Live with awe — Miracles (body, nature, technology, Israel's survival) must never become routine. Recognize daily yesh me'ayin (creation from nothing) and thank Hashem constantly.Grandparents & legacy — Seeing grandchildren/great-grandchildren is a privilege; influence positively without overstepping (e.g., no naming interference).The rabbi urges bold Jewish pride (yarmulke, tzitzit, tefillin in public) and relentless self-improvement—don't let others define your limits._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 3, 2026, in Houston, Texas.Released as Podcast on February 5, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Yisro, #Anochi, #JewishPride, #NoCoveting, #EmunahKnowledge, #IntentionalJudaism ★ Support this podcast ★

In this Parshas Yisro review, Rabbi Aryeh Wolbe highlights the unique honor of an entire Torah portion named after Yisro—Moshe's father-in-law and a former spiritual leader of Midian—despite no portion being named for Moshe, Aaron, Abraham, Isaac, Jacob, or Joseph. Yisro heard of the Exodus miracles (plagues, splitting of the sea, manna) and immediately acted: he left everything to join the Jewish people, converting and bringing practical wisdom (organizing judges).The rabbi stresses practical application over storytelling: the Torah is a “manual for living.” Yisro's response teaches that true emunah is knowledge—not blind faith. We know Hashem exists because “Anochi Hashem Elokecha asher hotzeticha me'eretz Mitzrayim” (I am Hashem your God who took you out of Egypt)—personal, witnessed miracles prove it.Key lessons:Don't assimilate to gain favor — The Jews in Egypt kept their names, language, and dress distinct, yet found chen (favor) in Egyptian eyes because Hashem granted it. Pride in authentic Judaism draws divine favor, which then reflects in others' eyes.Jealousy (lo tachmod) opposes knowledge of Hashem — The first commandment (Anochi Hashem) and last (don't covet) connect: coveting others' blessings denies Hashem's perfect design for you. Compare only to your own potential.Live with awe — Miracles (body, nature, technology, Israel's survival) must never become routine. Recognize daily yesh me'ayin (creation from nothing) and thank Hashem constantly.Grandparents & legacy — Seeing grandchildren/great-grandchildren is a privilege; influence positively without overstepping (e.g., no naming interference).The rabbi urges bold Jewish pride (yarmulke, tzitzit, tefillin in public) and relentless self-improvement—don't let others define your limits._____________This episode of the Parsha Review Podcast is dedicated in honor of Lenny & Teresa FriedmanDownload & Print the Parsha Review Notes:https://drive.google.com/drive/folders/1ncaRyoH5iJmGGoMZs9y82Hz2ofViVouv?usp=sharingRecorded at TORCH Meyerland in the Levin Family Studios (B) to a live audience on February 3, 2026, in Houston, Texas.Released as Podcast on February 5, 2026_____________Subscribe: Apple Podcasts (https://podcasts.apple.com/us/podcast/parsha-review-podcast-rabbi-aryeh-wolbe/id1651930083)Spotify (https://open.spotify.com/show/22lv1kXJob5ZNLaAl6CHTQ) to stay inspired! Share your questions at awolbe@torchweb.org or visit torchweb.org for more Torah content.  _____________About the Host:Rabbi Aryeh Wolbe, Director of TORCH in Houston, brings decades of Torah scholarship to guide listeners in applying Jewish wisdom to daily life.  To directly send your questions, comments, and feedback: awolbe@torchweb.org_____________Support Our Mission:Help us share Jewish wisdom globally by sponsoring an episode at torchweb.org. Your support makes a difference!_____________Subscribe and Listen to other podcasts by Rabbi Aryeh Wolbe: NEW!! Hey Rabbi! Podcast: https://heyrabbi.transistor.fm/episodesPrayer Podcast: https://prayerpodcast.transistor.fm/episodesJewish Inspiration Podcast: https://inspiration.transistor.fm/episodesParsha Review Podcast: https://parsha.transistor.fm/episodesLiving Jewishly Podcast: https://jewishly.transistor.fm/episodesThinking Talmudist Podcast: https://talmud.transistor.fm/episodesUnboxing Judaism Podcast: https://unboxing.transistor.fm/episodesRabbi Aryeh Wolbe Podcast Collection: https://collection.transistor.fm/episodesFor a full listing of podcasts available by TORCH at http://podcast.torchweb.org_____________Keywords:#Torah, #Parsha, #Exodus, #Shemos, #Yisro, #Anochi, #JewishPride, #NoCoveting, #EmunahKnowledge, #IntentionalJudaism ★ Support this podcast ★

Today's Case A 61-year-old male arrives at the emergency department by ambulance after being in a three-vehicle collision resulting in two fatalities. After the event he is openly joking about the accident, appears apathetic to the loss of life, and has urinary incontinence while speaking to the police. Field sobriety tests are conducted by the police in response to his behavior. The test is quickly suspended when the patient takes more than the instructed nine steps forward on three attempts. A breatha- lyzer test shows negative for alcohol. He denies having any discomfort and tries to leave the hospital (requiring redirection by staff ). He does not ask why he was brought to the hospital. His only visible injuries are minor chest contusions, likely from impact with the steering wheel. When asked how he's feeling, he repeatedly (and at times inappropriately) responds, “Right as rain.” His wife has been contacted and is on her way to the hospital. Today's Reader Ryan O'Connell is a junior biology major at Loyola Marymount University. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. More from Dr. Raj ⁠⁠⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Dr. Raj on Twitter⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Dr. Raj on Instagram⁠⁠⁠⁠⁠ Want more board review content? ⁠⁠⁠⁠⁠USMLE Step 1 Ad-Free Bundle⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Crush Step 1⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Step 2 Secrets⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Beyond the Pearls⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠The Dr. Raj Podcast⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Beyond the Pearls Premium⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠USMLE Step 3 Review⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠MedPrepTGo Step 1 Questions⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠MedPrepTGo Step 2 Questions⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Time Stamps:00:00 Start01:24 The growing animosity toward Israel10:58 Husbands and Wives that disagree on vaccines23:23 Can Jesus return before 1,000 generations?27:09 Did Jesus drink wine or grape juice?33:13 Street preaching tips38:40 Help! My husband is not leading our home spiritually45:28 The difference between discipline and love and encouragement51:11 Can you tell me when the rapture will happen?54:04 Women forced into leadership1:02:15 How to find the right church1:10:49 What happens when a believer dies?

A special release in honor of National Women Physicians Day 2026. Today's conversation is an invitation to notice overfunctioning with compassion. Overfunctioning may have helped you succeed in medicine but it often costs you intimacy, energy, and connection.   Overfunctioning and underfunctioning, as well as the resentment that follows, are a familiar relational dynamic. Overfunctioning is not a personality flaw; It's a role we step into. It is shaped by our training, context, and culture.   When we pause, rest, and allow space, we usually find that the world doesn't fall apart. Others step forward in their own time and way. Even when it feels unfamiliar, this shift can offer clarity, growth, and alignment with how we truly want to live and lead.     Pearls of Wisdom • Overfunctioning is a relational role developed in response to internal and external expectations. • When one person consistently does more, others often do less. Over time, the systems adapted this way. • Resentment is information. It often signals over-capacity. • Doing less can be an act of love that allows systems and relationships to reorganize. • When we stop stabilizing what's falling around us and tend to our own nervous systems first, is when change begins.     Reflection Questions Where in your life are you doing more than your share simply because you are capable? What feels most uncomfortable about stepping back? What might happen if you rest or stop managing? What would love do this week in your relationships or at work? Join me for coaching or a retreat to explore how to change the overfunctioning habit.  www.jessiemahoneymd.com In Mindful Love Small Group Coaching we specifically look at overfunctioining in the context of our intimate relationships. In Leading from the Heart and Transition Well Small Group Coaching  we work on it in the context of career and life pivots and leadership.  At retreats and advanced coaching, we work on moving beyond it in every realm of your life. If you are interested in having me speak to your group on overfunctioning or any of the topics discussed in this podcast, find out more here www.jessiemahoneymd.com/speaking or email me at jessie@jessiemahoneymd.com. Dr. Ni-Cheng Liang is also available to speak to your group. www.awakenbreath.com.   Other Healing Medicine Podcast episodes specifically relevant to Women Physicians you may want to explore: These episodes explore the inner experience of women physicians—without pathologizing it. 293. When Feedback Feels Threatening: Nervous System Wisdom for Women Physicians 292. When Physicians Stop Believing in Themselves: Burnout, Skepticism, and the Hidden Cost  290. The Overs, the Toxics, and Why Awareness Alone Isn't Enough  269. You Were Never Meant to Carry It All: Healing the Eldest Daughter Effect 259. What Are You Proud Of? A Conversation About Worth, Identity, and Redefining Success  154. Move Beyond Imposter Syndrome These episodes highlight connection, culture shift, and the idea that "you don't have to carry this alone." 275. The Power of an Introduction: How Women in Medicine Can Change Lives and Culture Through Connection  281. Be Radiantly You: The Antidote to Exhaustion and Judgment  263. It's Okay to Have Fun: The Evolution of a Happy Doctor (with Dr. Beni Seballos) 262. Standing Tall in Surgery: Finding Fulfillment Outside the Mold (with Dr. Jenny Kang)  261. From ER Burnout to Soulful Living: Enia Oaks on Poetry, Pause, and Healing  These episodes give practical frameworks for agency, boundaries, and sustainability. 289. How to Take Intentional Action So You Don't Burn Out  280. From Powerless to Purposeful: Reclaiming Choice and Agency in Medicine  279. Victimhood in Healthcare: Naming the Problem with Empathy and Truth  282. The Art of Not Fixing People  278. Finding Peace by Letting Go of Fixing, Managing, and Controlling  285. Mindfulness + Money: Rewriting Financial Stories for Physicians 239. Breaking the Over Helping Habit: Valuing Your Expertise as a Woman Physician *The Healing Medicine Podcast was formerly known as the Mindful Healers Podcast Nothing shared in the Healing Medicine Podcast is medical advice.

In this episode, we enter Matthew 7 with a defense of the most unfairly judged disciple in history: "Doubting" Thomas. (Spoiler: He was actually the first one willing to die for Jesus). Using Thomas as a backdrop for how easily we misjudge others, we dive into one of the most quoted—and misunderstood—verses in the Bible: "Judge not, lest ye be judged." We present a unique perspective: these verses aren't about ignoring sin (which we are commanded to address), but about being Judgmental (forming opinions on character) and Critical (nitpicking details like appearance or habits). Finally, we tackle the confusing warning about "giving holy things to dogs" and "pearls to pigs." The takeaway? Stop offering the blessings of the Kingdom to those who don't know the King—offer them Jesus instead. Key Topics Covered: Justice for Thomas: Why "Doubting Thomas" should actually be known as "Brave Thomas." Judge Not: Why Matthew 7:1-5 is about being judgmental and critical, not about ignoring sin. The Cloud of Blessing: You will only receive from God the grace you extend to others. Speck vs. Log: The difference between helpful correction and hypocritical criticism. Dogs & Attack Pigs: Why you shouldn't offer "sacred blessings" (like marriage covenants or deep spiritual peace) to those who reject God. They need Jesus, not His benefits. Scripture References: John 11:14-16, John 14:5, John 20:25 (The story of Thomas) Matthew 7:1-6 (Judging, Specks/Logs, Pearls before Swine) Matthew 15:21-28 Video Link: The Sermon for the Mounted: Part 8 - Unfair Judgment & Attack Pigs

On this podcast episode, I discuss important practice pearls and important test prep information about statins. Statins are cornerstone agents for ASCVD risk reduction, so test questions often focus on indication, intensity, and monitoring. Health care professionals should quickly identify statin intensity: high-intensity therapy (atorvastatin 40–80 mg, rosuvastatin 20–40 mg) lowers LDL by ~50% and is indicated for patients with clinical ASCVD, LDL ≥190 mg/dL, or high-risk diabetes patients age 40–75. Moderate-intensity statins (e.g., atorvastatin 10–20 mg, simvastatin 20–40 mg) are commonly tested for primary prevention. Statin-associated muscle symptoms range from myalgias (most common, normal CK) to rare but serious rhabdomyolysis (marked CK elevation and AKI). Risk factors include high doses, advanced age, hypothyroidism, drug interactions, and renal impairment. If muscle symptoms occur, stopping the statin, ruling out secondary causes (like hypothyroidism), and rechallenging with a lower dose or different statin is often the correct clinical approach. Drug interactions and statin selection frequently separate good from great test-takers. Lipophilic statins (simvastatin, atorvastatin, lovastatin) are more prone to muscle effects and CYP3A4 interactions, while hydrophilic statins (pravastatin, rosuvastatin) are preferred in patients with prior intolerance or complex drug regimens. Grapefruit juice, strong CYP3A4 inhibitors, and certain calcium channel blockers raise simvastatin levels—often prompting dose limits or avoidance on exams. If LDL goals aren’t met, adding ezetimibe or a PCSK9 inhibitor is the next evidence-based step. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

We have a classic episode for you. Master male hypogonadism diagnosis and management. Discover when and how to test, how to tackle confounding conditions, and why lifestyle changes may be more effective than testosterone therapy in certain patients. We are joined by Dr. Brad Anawalt, an expert in endocrine care, to guide us through the essentials.Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMEShow Segments Intro Case 1 History and Physical  Laboratory Testing  Effect of Lifestyle on Testosterone Case 2 Prostate and Cardiovascular risk Treatment Options and Considerations Secondary Causes of Hypogonadism Case 3 Testicular Size and Klinefelter Syndrome hCG and Clomiphene Monitoring and Follow-Up Take-Home Points Outro Credits Written and produced by Paul Wurtz MD. Show notes, cover art, and infographic also created by Paul Wurtz MD.  Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Sai S Achi MD, MBA, FACP Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Bradley D. Anawalt MD Sponsor: GustoTry Gusto today at gusto.com/CURB, and get three months free when you run your first payroll.Sponsor: LocumstoryLocumstory.com is literally just a free, unbiased resource dedicated to educating physicians about locums.  Sponsor: MedStudy PodcastCurbsiders listeners get 15% off with code CURB15 at medstudy.comSponsor: The Sanford GuideCurbsiders listeners can get 20% off the already very moderately priced yearly subscriptions directly at sanfordguide.com. Go to sanfordguide.com and use the code, CURB at checkout.