McMaster Demystifying Medicine Seminar Series

Learning Objectives: To appreciate Crohn's disease as a chronic inflammatory bowel disease responsive to immune suppressive therapy To understand why microbial triggers may be responsible for inflammatory changes in the gut To understand current research into the role of microbes in Crohn's pathogenesis To understand how microbes may work in concert with other known risk factors for Crohn's disease

Learning Objectives: To appreciate Crohn's disease as a chronic inflammatory bowel disease responsive to immune suppressive therapy To understand why microbial triggers may be responsible for inflammatory changes in the gut To understand current research into the role of microbes in Crohn's pathogenesis To understand how microbes may work in concert with other known risk factors for Crohn's disease

Learning Objectives: Understanding the relationship between engineering and the body Understanding how the different branches of engineering can be applied to different diseases or treatments or diagnostic options Give specific examples of treatments in the eye and how the engineering has evolved over time Describe specific potential future options for marrying engineering and medicine

Learning Objectives: Understanding the relationship between engineering and the body Understanding how the different branches of engineering can be applied to different diseases or treatments or diagnostic options Give specific examples of treatments in the eye and how the engineering has evolved over time Describe specific potential future options for marrying engineering and medicine

To review the pathophysiology of cardiovascular disease To review the importance of genetics in cardiovascular disease Recent genetic approaches used to decipher the causes of cardiovascular disease PCSK9 inhibitors: the holy grail in the treatment of cardiovascular disease?

To review the pathophysiology of cardiovascular disease To review the importance of genetics in cardiovascular disease Recent genetic approaches used to decipher the causes of cardiovascular disease PCSK9 inhibitors: the holy grail in the treatment of cardiovascular disease?

To appreciate the clinical effects of allergic disease To understand the need for new treatments for allergic disease To understand how the immune system tolerates some proteins, but reacts to others, leading to allergic disease To appreciate how we can re-establish long-lasting tolerance to allergen proteins, thus "curing" allergic disease

To appreciate the clinical effects of allergic disease To understand the need for new treatments for allergic disease To understand how the immune system tolerates some proteins, but reacts to others, leading to allergic disease To appreciate how we can re-establish long-lasting tolerance to allergen proteins, thus "curing" allergic disease

To understand the reasons why nutrition so often seems to provide "mixed messages" To understand the methodological challenges in assessing diet-disease relationships

To understand the reasons why nutrition so often seems to provide "mixed messages" To understand the methodological challenges in assessing diet-disease relationships To appreciate the limitations inherent when using surrogates as outcomes in clinical trials (e.g. blood pressure vs. CVD events) To appreciate the limitations of the scientific evidence upon which dietary guidelines have historically been based (i.e.. sodium, saturated fat)

To understand the reasons why nutrition so often seems to provide "mixed messages" To understand the methodological challenges in assessing diet-disease relationships To appreciate the limitations inherent when using surrogates as outcomes in clinical trials (e.g. blood pressure vs. CVD events) To appreciate the limitations of the scientific evidence upon which dietary guidelines have historically been based (i.e.. sodium, saturated fat)

To understand the clinical presentation of asthma To understand the importance of an accurate diagnosis and how to make it Bedside-bench-bedside in asthma: the story of sputum cytometry Importance of understanding the pathophysiology of disease to guide management strategies

To understand the clinical presentation of asthma To understand the importance of an accurate diagnosis and how to make it Bedside-bench-bedside in asthma: the story of sputum cytometry Importance of understanding the pathophysiology of disease to guide management strategies

Understand what is depression and how is it treated Why do some people get depressed Why does depression run in families How can science help to better understand and treat depression

Understand what is depression and how is it treated Why do some people get depressed Why does depression run in families How can science help to better understand and treat depression

Understand how patients with heart disease may develop kidney dysfunction Review the association between heart disease in patients with chronic kidney disease Learn the physiological processes in chronic renal disease that may lead to chronic heart disease Understand how research in biomedical science is developing new targets to interfere with these processes

Understand how patients with heart disease may develop kidney dysfunction Review the association between heart disease in patients with chronic kidney disease Learn the physiological processes in chronic renal disease that may lead to chronic heart disease Understand how research in biomedical science is developing new targets to interfere with these processes

Describe the epidemiology of prediabetes and type 2 diabetes in children Describe immune system involvement in obesity and its association with prediabetes and diabetes To understand what goes wrong with insulin action in pre-diabetes (i.e. insulin resistance) To understand how links between the immune and metabolic systems influence insulin resistance

Describe the epidemiology of prediabetes and type 2 diabetes in children Describe immune system involvement in obesity and its association with prediabetes and diabetes To understand what goes wrong with insulin action in pre-diabetes (i.e. insulin resistance) To understand how links between the immune and metabolic systems influence insulin resistance

Review the changing demographics of HIV/AIDS Discuss current management of HIV and co-morbidities Explore the patient's perspective of ageing well with HIV Understand HIV as a chronic infl ammatory disease process

To discuss pathological relevance of immune infiltrates in tumors To illustrate the history of immune-directed therapy in cancer treatment To review the currently available immunotherapies in solid tumours To identify challenges that remain to be overcome

To discuss pathological relevance of immune infiltrates in tumors To illustrate the history of immune-directed therapy in cancer treatment To review the currently available immunotherapies in solid tumours To identify challenges that remain to be overcome

Review the changing demographics of HIV/AIDS Discuss current management of HIV and co-morbidities Explore the patient's perspective of ageing well with HIV Understand HIV as a chronic infl ammatory disease process

To understand the current health challenges related to obesity in Canadian Children To understand the developmental origins of adult disease hypothesis To review the influence of early life exposure on subsequent cardiometabolic health in children and disease To learn how studies in the basic science laboratory are helping us to unravel the mechanisms responsible for this relationship

To understand the current health challenges related to obesity in Canadian Children To understand the developmental origins of adult disease hypothesis To review the influence of early life exposure on subsequent cardiometabolic health in children and disease To learn how studies in the basic science laboratory are helping us to unravel the mechanisms responsible for this relationship

Learning Objectives: To understand the anatomy and physiology of the umbilical cord To explore the research about the effect of cord clamping on the health of the newborn To understand the role of placental transfusion in newborn transitional physiology To explore the potential conflicts between cord clamping, cord blood-derived stem cell harvesting and cord-derived stem cell harvesting

Learning Objectives: To understand the anatomy and physiology of the umbilical cord To explore the research about the effect of cord clamping on the health of the newborn To understand the role of placental transfusion in newborn transitional physiology To explore the potential conflicts between cord clamping, cord blood-derived stem cell harvesting and cord-derived stem cell harvesting

Learning Objectives: To briefly review the genetic epidemiology of autism To understand our current understanding of the genetic architecture of autism To highlight potential advances in diagnostics and therapeutics that might arise To explore the potential of stem cell research in understanding the etiology of autism

Learning Objectives: To briefly review the genetic epidemiology of autism To understand our current understanding of the genetic architecture of autism To highlight potential advances in diagnostics and therapeutics that might arise To explore the potential of stem cell research in understanding the etiology of autism

Learning Objectives: Review the long-term health consequences of diabetes List the therapies that reduce these consequences Understand how diabetes causes some of these consequences Learn if therapies directed at the cause can reduce these consequences

Learning Objectives: Review the long-term health consequences of diabetes List the therapies that reduce these consequences Understand how diabetes causes some of these consequences Learn if therapies directed at the cause can reduce these consequences

learning Objectives: Understand the epidemiology of West Nile virus Review the clinical manifestations and management strategy Better understand the host response to West Nile virus Understand current research strategies to target West Nile virus infections

Learning Objectives: Understand the epidemiology of West Nile virus Review the clinical manifestations and management strategy Better understand the host response to West Nile virus Understand current research strategies to target West Nile virus infections

This seminar will tell the story of the Hamilton Spectator Code Red series and its demonstration of wide variation in health between Hamilton neighbourhoods, video-taped interviews will elicit the experiences of patients and their families and the seminar will end with a presentation designed to impart understanding of the impact that social factors have on the practice of clinical medicine.

This seminar will tell the story of the Hamilton Spectator Code Red series and its demonstration of wide variation in health between Hamilton neighbourhoods, video-taped interviews will elicit the experiences of patients and their families and the seminar will end with a presentation designed to impart understanding of the impact that social factors have on the practice of clinical medicine

Learning Objective: To review the current management and treatment of childhood medulloblastoma To understand the clinical implications of medulloblastoma from a patient's point of view To discuss recent evidence for the presence of a medulloblastoma stem cell that drives tumorigenesis in this malignant childhood tumor. To understand how developmental signaling pathways may be aberrantly activated to cause this childhood brain tumour.

Learning Objectives: To review the current management and treatment of childhood medulloblastoma To understand the clinical implications of medulloblastoma from a patient's point of view To discuss recent evidence for the presence of a medulloblastoma stem cell that drives tumorigenesis in this malignant childhood tumor. To understand how developmental signaling pathways may be aberrantly activated to cause this childhood brain tumour.

Learning Objectives: To understand how COPD develops (in people and in experimental models) To understand how COPD affects patients To examine the role of infections in the progression of COPD To identify the areas for future investigation in COPD

Learning objectives: To understand how COPD develops (in people and in experimental models) To understand how COPD affects patients To examine the role of infections in the progression of COPD To identify the areas for future investigation in COPD

Learning Objectives: Describe delirium as a consequence of acute illness in older people Recognize deconditioning as a preventable problem in older people Investigate current hypotheses about why we live as long as we do, why there is a gender difference in the aging trajectory and why our health fails with age. Understand the role of chronic inflammation in the aging process and how it contributes to age-related diseases such as dementia

Learning Objectives: Describe delirium as a consequence of acute illness in older people Recognize deconditioning as a preventable problem in older people Investigate current hypotheses about why we live as long as we do, why there is a gender difference in the aging trajectory and why our health fails with age. Understand the role of chronic inflammation in the aging process and how it contributes to age-related diseases such as dementia

Outline the general concept of healing, scar formation and fibrosis. Understand the clinical presentation of debilitating lung fibrosis and how it worsens over time. Review the pathobiology underlying lung fibrosis. Understand how these pathogenetic concepts are translated into drug development.

Outline the general concept of healing, scar formation and fibrosis. Understand the clinical presentation of debilitating lung fibrosis and how it worsens over time. Review the pathobiology underlying lung fibrosis. Understand how these pathogenetic concepts are translated into drug development.

Outline a clinical approach to proteinuria and nephrotic syndrome General review of treatment of nephrotic syndrome and focal segmental glomerulosclerosis Understand the glomerular filtration barrier and basic mechanisms of proteinuria Review the structure and function of podocytes and novel concepts of anti-proteinuric agents

Outline a clinical approach to proteinuria and nephrotic syndrome General review of treatment of nephrotic syndrome and focal segmental glomerulosclerosis Understand the glomerular filtration barrier and basic mechanisms of proteinuria Review the structure and function of podocytes and novel concepts of anti-proteinuric agents

What is asthma and how is it diagnosed? What are the reasons that patients develop asthma? What are the best ways to treat asthma and how effective is treatment? Also, what are the possible side-effects from the treatments used? What are we learning about the mechanisms behind asthma, and is this knowledge bringing us closer to a cure or better management?