Podcasts about medulloblastoma

Most common type of primary brain cancer in children

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Best podcasts about medulloblastoma

Latest podcast episodes about medulloblastoma

Help and Hope Happen Here
Matt Meo will talk about his 140 mile run which took him 45 hours 56 minutes and 11 second complete to honor his son Landon and 105 other Pediatric Cancer Warriors in March of this year.

Help and Hope Happen Here

Play Episode Listen Later May 22, 2025 86:24


After Matt and Breanna's son 10 1/2 year old son Landon passed away from Medulloblastoma in December of 2022, Matt took up running as a way to cope with the grief from his beloved son's passing. In March of this year, Matt's running took him to Lake Folsom in Auburn California where he lives and he began a 140 mile run that honored the memory of Landon and honored 105 other Pediatric Cancer Warriors, some of whom are fighters. some of whom are survivors, and some of whom have passed away. This amazing accomplished was also captured on a 45 minute film which was put together by his "crew" of helpers who helped Matt every step of the way. 

The ResearchWorks Podcast
Episode 206 (Professor Nick Gottarrdo)

The ResearchWorks Podcast

Play Episode Listen Later Mar 29, 2025 67:56


Professor Nick Gottardo walks us through medulloblastomas - a comprehensive master class for clinicians and researchers.  Expect to learn about early signs and symptoms, diagnosis, treatment and prognosis. Dr Nick breaks this down beautifully.What was really clear throughout our discussion was that collaboration is key. Given the incidence of medulloblastomas and the specific subtypes that fall within this category, it would not be possible to develop effective treatments that minimise detrimental side effects without coming together with centres across the world.This episode is truly special so if you want to know the current state of the evidence when it comes to treating medulloblastomas - this is a must listen episode.

Help and Hope Happen Here
Stacie Eirich will talk about the side effects and after effects that her now 16 year old daughter Sadie has been struggling with over the past 2 years since she was diagnosed with Medulloblastoma when she was 14

Help and Hope Happen Here

Play Episode Listen Later Mar 27, 2025 53:42


Side Effects and After Effects from any Pediatric Cancer battle can be very difficult, especially when there are so many side effects that are concerning after being diagnosed with Pediatric Brain Cancer. That is certainly the case as we just heard from Stacie Eirich in talking about her daughter Sadie who has had more than a few difficult obstacles to overcome. The hope is that she will find the right people and programs to help Sadie through her toughest times. 

Help and Hope Happen Here
Shana Kline will talk about her son Aaron who was diagnosed with Medulloblastoma in 2002 when he was 4 years old, and is now a 6 year old active 1st grade student.

Help and Hope Happen Here

Play Episode Listen Later Jan 30, 2025 64:04


After taking a swimming lesson in late July of 2022 in very hot conditions, 4 year old Aaron Kline showed concerning symptoms which led his mother Shana to take him to see his pediatrician. A few days later, Aaron was diagnosed with the Pediatric Brain Cancer Medulloblastoma. 7 months later, Aaron completed his treatment at Children's Hospital of Philadelphia and is currently feeling and doing well as a 6 year old first grade student. 

Help and Hope Happen Here
Tanya and Luke Palmowski will talk about their son Tyler who was diagnosed with Medulloblastoma when he was 8 years old in 2015, recovered, and then was diagnosed 5 years later with DIPG

Help and Hope Happen Here

Play Episode Listen Later Jan 6, 2025 69:38


Hopefully for the 1ST and LAST time, I spoke with a mom and dad who had what I am calling a misfortune on Steroids when Tanya and Luke Palmowski's son Tyler was diagnosed with Medulloblastoma when he was 8 years old in 2015, was able to ring the bell at Stollery Children's Hospital in Edmonton, Albert 1 year later in 2016, and then just as Covid was hitting in March of 2020 was diagnosed with DIPG. Tyler passed away on November 24th of 2020 .

Help and Hope Happen Here
Jamie Moore will talk about her son Mason who was diagnosed in February of 2023 with Anaplastic Large Cell Medulloblastoma , went through a very difficult 10 month battle against this pediatric brain cancer and passed away on November 6th of 2023

Help and Hope Happen Here

Play Episode Listen Later Oct 10, 2024 67:16


When Jamie Moore's 6 year old son Mason was experiencing headaches, having vomiting episodes, and having little energy, she and her husband were frustrated at first by the response they were receiving from doctors who did not recognize that what was happening to Mason was a "head issue". Mason was finally diagnosed with Anaplastic Large Cell Medulloblastoma on February 20th of 2023, had much of his treatment at St. Jude Childrens Research Hospital in Memphis, but for the most part the difficult treatment that he underwent did not help and he passed away on November 6th of 2023, just 10 months after his diagnosis. 

Help and Hope Happen Here
Stacie and Sadie Eirich will talk about Sadie's diagnosis of the pediatric brain cancer Medulloblastoma located in the pineal region of the brain, which came when Sadie was 14 years old in October of 2022

Help and Hope Happen Here

Play Episode Listen Later Aug 22, 2024 66:47


Sadie Eirich's left eye seemed out of position in the early fall of 2022 and eventually led to her diagnosis in October of that year of the Pediatric Brain Cancer Medulloblastoma, which was located in the pineal region of her brain. Sadie was 14 years old at the time and her treatment initially took her to a children's hospital in Jefferson Louisiana where she had 5 surgeries, followed by 9 months of treatment at St. Jude Children's Research Hospital from December of 2022 through September of 2023. Sadie was found to have No Evidence of Disease in September of 2023 and that situation continues to be the case nearly a year later. 

This Week in America with Ric Bratton
Episode 3056: BEYOND A DIAGNOSIS (A JOURNEY THROUGH CANCER) by Grace Boykin

This Week in America with Ric Bratton

Play Episode Listen Later Aug 8, 2024 25:55


BEYOND A DIAGNOSIS ( A JOURNEY THROUGH CANCER) by Grace BoykinA memoir of her son Weslee Sheaffer. His birth, head banging, and having to drive him around the neighborhood for him to sleep. His many creative talents. Travel to Japan as Rotary exchange student and stayed in many homes in south and Northern Japan. He loved to travel! Cancer diagnosis of Medulloblastoma brain cancer, chemotherapy, and radiation treatment at Shands Hospital in Gainesville, Florida. Later he had a Meningioma Brain Tumor, His last was a glio-blastoma brain tumor with tentacles which is very rare to have 3 different types of brain cancer. His Celebration of Life as he died at age 32. Author Grace Boykin a native of Mobile, Alabama, Clearwater, Florida. Received B.A. degree in Social Science and Secondary Education from Flagler College in St. Augustine, Florida. Studied Art in Europe with Spring Hill College, Mobile, Alabama. Debut in Mobile and member of the Mardi Gras Court. Employed at Walt Disney World in Orlando, Florida. Taught Geography at Dunedin Junior High School and History in several schools throughout Melbourne, Florida. Tutored Braille and worked with the Blind at the Florida School of Deaf and Blind in St. Augustine, Fl. Taught and created a Mass Media Curriculum for High School students and Directed the High school play “To Serve a Higher King”, in Palm Bay, Florida.Has published works of Poetry, Fiction books The Southern Hunt, and Deaf, Blind, and Tragedy. Autobiography of Grace Browder Boykin, A Turbulent Life ? ? ?, South Of The Hill, memoir about the Political Years 1930's to 1960's of Frank W. Boykin as a U.S, Congressman for twenty-eight years and his having over 20 jobs during his lifetime., Beyond A Diagnosis, (A Journey Through Cancer) memoir of son Weslee Sheaffer. Babies Swimming Class. Grace Boykin is resident of Milton, Florida after traveling and driving all the states on backroads when possible. Visited 25 national parks and 25 countries. Her passions writing novels and carrying a camera in hand to make the next great movie.https://www.amazon.com/Books-Grace-Boykin/s?rh=n%3A283155%2Cp_27%3AGrace+Boykin  https://www.urlinkpublishing.com/http://www.bluefunkbroadcasting.com/root/twia/8824urlgb.mp3

At The Beam
S2E22 Medulloblastoma feat Dr Steven Montalvo

At The Beam

Play Episode Listen Later May 31, 2024 26:39


Workup and management of Medulloblastoma in Radiation Oncology featuring guest Dr Steven Montalvo

Help and Hope Happen Here
Abby Wagle met Ella Bresee when she was 12 years old in 2019. They quickly became best friends and then in 2021, Ella was diagnosed with Medulloblastoma. Abby will talk about losing Ella to this disease in 2022 and how she has honored her friend since.

Help and Hope Happen Here

Play Episode Listen Later Mar 21, 2024 44:42


Abby Wagle and Ella Bresee met in 2019 when they played competitive basketball against each other. They quickly became best friends and then in 2021, Ella was diagnosed with the Pediatric Brain Cancer Medulloblastoma. Abby is now a sophomore in high school and will talk about the close friendship that she and Ella had, and how difficult it was when Ella passed away in September of 2022. Abby will talk about the many ways that she has honored her friend since then and will continue to honor her in the years to come. 

Help and Hope Happen Here
Shauna Falvey will talk about her 6 year old daughter Mia who was diagnosed with Medulloblastoma in the summer of 2022 and has been dealing with one obstacle after another during her 20 month treatment protocol.

Help and Hope Happen Here

Play Episode Listen Later Feb 26, 2024 45:30


It took a confirmation from St. Jude Children's Research Hospital to finally confirm that 6 year old Mia Falvey had Medulloblastoma after waiting for an official diagnosis for more than 30 days. Since the summer of 2022 Mia has been under treatment for this most common form of Pediatric Brain cancer and is waiting for an upcoming MRI which will tell the doctors what her next treatment protocol will look like. 

Help and Hope Happen Here
Sophia Takla was crowned Miss Oregon in 2022 and had a top 10 finish in the 2023 Miss America Pageant. Sophia is also a huge advocate for the cause of Pediatric Cancer as she will explain on today's podcast.

Help and Hope Happen Here

Play Episode Listen Later Dec 21, 2023 50:04


Sophia Takla's 8 year old cousin Tristan passed away from Medulloblastoma 15 years ago when Sophia was 8 years old, as was Tristan. Sophia will talk about that period of time and what she has been doing as a Pediatric Cancer advocate since his Tristan's passing and will continue to do for many years to come.  Sophia will also discuss her being crowned Miss Oregon in June of 2022 and her top 10 finish in the Miss America Pageant in 2023.  Sophia has accomplished so much in her life already and at 23 years old, has an incredibly promising future ahead . 

Help and Hope Happen Here
Breanna and Matt Meo will talk about their son Landon who passed away after a 21 month battle with Medulloblastoma on December 17th of 2022.

Help and Hope Happen Here

Play Episode Listen Later Nov 13, 2023 58:53


After being diagnosed with Medulloblastoma in March of 2021, Breanna and Matt Meo's 8 year old son Landon was admitted to St. Jude Children's Research Hospital to begin a clinical trial which was working well until Landon relapsed in March of 2022. Breanna and Matt will talk about the difficult treatment that Landon went through as well as some good times, especially in the first few months of 2022 when he was able to attend 3 Sacramento Kings basketball games, meet the players from that team, and meet Lebron James on April 7th, 8 months before his December 17th 2022 passing. 

Help and Hope Happen Here
Amanda Hawkins will talk about her 7 year old daughter Ashton who was diagnosed with Medulloblastoma on August 22nd of this year and faces a number of challenges as she moves through her cancer battle.

Help and Hope Happen Here

Play Episode Listen Later Oct 16, 2023 50:08


On August 22nd of this year, exactly 8 weeks before today's podcast is being published, 7 year old Ashton Hawkins was diagnosed with the Pediatric Brain Cancer Medulloblastoma. On today's podcast, Ashton's mom Amanda will talk about what Ashton has been through over the past 8 weeks and what challenges that she faces as her treatment protocol is still in its early stages. 

The Health Formula Show
111: Baby Gut Health, Best Pregnancy Supplements, Warts Causes, Medulloblastoma

The Health Formula Show

Play Episode Listen Later Sep 1, 2023 19:47


Explore the benefits of zinc ointments, natural sources of vitamin A, top supplements for a healthy pregnancy and the potential factors contributing to the development of medulloblastomas! Tune in to hear: Healing the gut of a 1 year old (1:38) Essential supplements for a healthy pregnancy (4:04) An important vitamin you need during pregnancy (7:00) Understanding the root causes of warts (11:29) Medulloblastomas: what you should know (16:06)  Head to www.paulabenedi.com/episode111 for the show notes. Join my newsletter: www.synergised.info/newsletter Follow me on Instagram: @synergiseduk . P.S. This podcast and website represents the opinions of Paula Benedi. The content here should not be taken as medical advice and is for informational purposes only, and is not intended to diagnose, treat, cure or prevent any disease. Please consult your healthcare professional for any medical questions.

Pillole di Pediatria
Medulloblastoma

Pillole di Pediatria

Play Episode Listen Later Aug 16, 2023 5:26


In questo episodio parleremo di medulloblastoma. Con l'aiuto degli specialisti dell'Ospedale Pediatrico Bambino Gesù, scopriremo come si manifesta, come si fa la diagnosi e come si cura. Episodio registrato martedì 6 giugno 2023.

Winning the War on Cancer (Video)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Winning the War on Cancer (Video)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Science (Video)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Science (Video)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Health and Medicine (Video)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Health and Medicine (Video)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

University of California Audio Podcasts (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

University of California Audio Podcasts (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Health and Medicine (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Health and Medicine (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Science (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Science (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

UC San Diego (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

UC San Diego (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Winning the War on Cancer (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Winning the War on Cancer (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Stem Cell Channel (Audio)
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott

Stem Cell Channel (Audio)

Play Episode Listen Later Aug 5, 2023 67:46


Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

The Medbullets Step 2 & 3 Podcast
Oncology | Medulloblastoma

The Medbullets Step 2 & 3 Podcast

Play Episode Listen Later Apr 18, 2023 10:44


In this episode, we review the high-yield topic of Medulloblastoma⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Neurology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

Oncotarget
WNT-pathway Medulloblastoma: What Constitutes Low-risk and How Low Can One Go?

Oncotarget

Play Episode Listen Later Feb 27, 2023 4:11


A new research perspective was published in Oncotarget's Volume 14 on February 7, 2023, entitled, “WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go?” Novel biological insights have established that medulloblastoma is a heterogenous disease comprising four broad molecular subgroups - WNT, SHH, Group 3, and Group 4 respectively, resulting in the incorporation of molecular/genetic information in 5th edition of WHO classification and contemporary risk-stratification. Concerns regarding therapy-related late toxicity in long-term survivors have led to systematic attempts at treatment de-intensification in good-risk medulloblastoma. Given the excellent survival (>90%) of WNT-pathway medulloblastoma, prospective clinical trials have focused on optimization of therapy to balance survival versus quality of survival. The currently accepted definition of low-risk WNT-pathway medulloblastoma includes children

The Lighthouse Podcast
Episode 96 | Priorities During The Journey

The Lighthouse Podcast

Play Episode Listen Later Dec 20, 2022 33:08


For our last episode of season five, Chris and Christy hosted Cory and Lix Mixdorf. The Mixdorf family has five children - Miles (age 14), Madelyn (age 12), Mason (age 11, Meyer (age 6), and Monty (age 5). Their cancer journey began when Myer was diagnosed with Medulloblastoma at four. From the beginning of the journey, they decided they didn't want this diagnosis to negatively impact their family and marriage. They chose to prioritize time together as a family and a married couple, no matter the circumstance. During the journey, they experienced an incredible community and many blessings. In closing, Cory and Liz shared some personal advice about walking the kids through trauma, not hiding their emotions, and accepting help when offered. Last but not least, they encourage families not to waste the story God is writing in your life. As we end season five, we have to take a moment to say "thank you." Thank you for listening each week. Thank you for sharing the podcast with friends and family. We will return for season six on February 7, 2023. In the meantime, please share your feedback on the Lighthouse Podcast with us: https://www.surveymonkey.com/r/ZF6LWV9 Follow Lighthouse on Social Media: Facebook: https://www.facebook.com/lighthousefamilyretreat Instagram: http://instagram.com/lighthousefr

Help and Hope Happen Here
Michael Pruitt will talk about his son Rylan who passed away from the very rare Pediatric Brain Cancer Medullomayoblastoma in March of this year when he was 6 years old. Michael will talk about Rylan's heroic fight on today's podcast.

Help and Hope Happen Here

Play Episode Listen Later Oct 24, 2022 46:54


The Pediatric Brain Cancer Medullomayoblastoma is not the same cancer as the much more common Medulloblastoma. On today's podcast Michael Pruitt will talk about his son Rylan who was diagnosed with this cancer when he was 5 years old in the spring of 2021, and passed away from it at the age of 6, on March 10th of this year. Before Rylan's diagnosis, only 51 cases of this cancer had been diagnosed with only 1 known survivor. Michael will also talk about the Rylan Strong Network that he founded, which has a major component of trying to enact legislation that will make certain that insurance companies and the particular hospital that a child is being treated at will pay for treatment, even if an insurance contract has not been signed. 

Oncotarget
Press Release: An ABC Transporter as a Potential Target Against SHH-Medulloblastoma

Oncotarget

Play Episode Listen Later Sep 15, 2022 4:15


A new editorial paper was published in Oncotarget on September 8, 2022, by researchers Jingwen Zhu, Joseph N. Miller and John D. Schuetz from St. Jude Children's Research Hospital in Memphis, Tennessee, entitled, “An ABC transporter as a potential target against SHH-Medulloblastoma: From Benchtop to Bedside.” Medulloblastoma (MB) is a common malignant pediatric brain tumor divided into four main subgroups (WNT, SHH, Group 3 and 4). The most prevalent MB in children

WEEI/NESN Jimmy Fund Radio-Telethon
Olivia Tassinari (TASS-IN-AR-REE), 8, medulloblastoma, Plymouth, with parents, Andrea and Jason, and Dr. Susan Chi, Pediatric Hematology and Oncology, Dana-Farber

WEEI/NESN Jimmy Fund Radio-Telethon

Play Episode Listen Later Aug 23, 2022 9:54


 Olivia was diagnosed with a medulloblastoma brain tumor, the size of a small egg, in the lower back part of her brain, close to the brain stem in February 2016. Her parents had noticed she was vomiting and had some minor imbalance while walking. Olivia had six months of chemotherapy that started in March 2016. During her treatment, she had a Broviac port, several blood transfusions, a lumbar puncture and bone marrow scan, and a stem cell treatment plan. She had five different chemotherapy medications during her 6-month treatment. Her treatment endedSeptember 2016, although she does have her regular brain and spine scans every six months. Her doctors are Dr. Susan Chi and Dr. Michelle Lee. She also had two surgeries in 2020 after finding a vascular lesion (small bleeding blood vessel) in the front left part of Olivia's brain. Olivia is going into the third grade. She plays soccer, does gymnastics, loves doing Ninja, and takes dance. Her family is grateful to Dana-Farber for the degree of patient and family care they provide. They feel no details are overlooked or taken for granted. They say, “Dana-Farber makes you feel as though you are the most important person thereand you become part of a group that you have a connection with forever.” Andrea ran the Boston Marathon in 2016 during Olivia's treatment and Jason runs an "Olivia Strong" night every season at a Bristol Community College soccer game, where he is a coach, to raise money for the Jimmy Fund.

Help and Hope Happen Here
Elizabeth Allen survived her battle with Medulloblastoma which she was diagnosed with in 2004 and is now a graduate student at Tufts University. She will discuss the importance of the seldom talked about subject of nutrition for Pediatric Cancer patients

Help and Hope Happen Here

Play Episode Listen Later Aug 15, 2022 43:39


After being diagnosed with the pediatric brain cancer Medulloblastoma in 2004, Elizabeth Allen was able to survive her battle and move on to where she is now a graduate student at Tufts University, where she is studying nutrition, epidemiology, data science, and public health. Elizabeth will discuss the fact that of the many important facets of Pediatric Cancer and how they affect these kids, the subject of Nutrition is not prioritized and is not really talked about with any regularity. 

Help and Hope Happen Here
Jaclyn and Denis Murphy will talk about Jaclyn's successful fight against Medulloblastoma, and how a gesture from the Women's Lacrosse team from Northwestern led to the Friends of Jaclyn Foundation and its Adopt A Child program.

Help and Hope Happen Here

Play Episode Listen Later May 26, 2022 67:13


Jaclyn Murphy was diagnosed with Medulloblastoma when she was 9 years old. During her treatment, the Women's Lacrosse Team from Northwestern University found out about what Jaclyn was going through, and "Adopted" her as a team member. This act of kindness proved to be a special one for both Jaclyn and Northwestern, so much so that Jaclyn's father Denis and the Murphy family started the Friends Of Jaclyn Foundation. The central theme of this Foundation centers around its Adopt A Child Program, in which colleges and high schools around the country "Adopt" a Pediatric Cancer patient and make them a team member. This foundation was started in 2005 and is nearing 1000 patients that have been adopted with many more to join them in the future.Jaclyn is now 27 years old and is able to live a life of good health as she and her dad give so much back to kids who need it the most.

You're Kidding, Right?
Medulloblastoma | the most common malignant brain tumour in children

You're Kidding, Right?

Play Episode Listen Later May 15, 2022 15:03


Medulloblastomas are the most common malignant brain tumour in children. They arise from embryonal neuroepithelial cells and are usually located in the cerebellum, which can cause cerebellar signs. Due to its location, the tumour can also compress the 4th ventricle, causing hydrocephalus. Definitive diagnosis is based on histology from surgical resection of the tumour, after which point children will also undergo radiotherapy and chemotherapy.  Follow us on Instagram @yourekiddingrightdoctors Our email is yourekiddingrightpod@gmail.com Make sure you hit SUBSCRIBE/FOLLOW so you don't miss any episodes and RATE to help other people find us! (This isn't individual medical advice, please use your own clinical judgement and local guidelines when caring for your patients)

Help and Hope Happen Here
Danielle Leach lost her son Mason to Medulloblastoma in October of 2007. Since that time Danielle has become one of the most well known and passionate advocates for the cause of both Pediatric Cancer in general and specializing in Pediatric Brain Cancer.

Help and Hope Happen Here

Play Episode Listen Later Mar 21, 2022 51:18


After a 15 month battle with Medulloblastoma which began in July of 2006 and sadly ended in October of 2007, 5 year old Mason Leach lived a very short and very meaningful life. Mason's mother Danielle will detail Mason's battle and will talk about what she has done since that time to fight for all of these kids who have suffered from both Pediatric Brain Cancer and other cancers that kids have unfortunately been diagnosed with.Danielle will talk about her current position as the Director of Advocacy and Government Relations at the National Brain Tumor Society, and will discuss many of the advancements in the Pediatric Cancer fight that she has been involved with. 

Help and Hope Happen Here
Patti and Al Gustafson will talk about their son Michael who lost his battle with Medulloblastoma when he was 15 years old. They will be joined by Dr. Angela Waanders who will talk about the importance of post mortem brain tumor donations.

Help and Hope Happen Here

Play Episode Listen Later Feb 28, 2022 49:19


Patti and Al Gustafson will talk about their son Michael, who passed away after a 5 year battle  with the pediatric brain cancer Medulloblastoma, During the late stages of his disease, Michael told his mom that he willing to give up his life "so that he could see if I can find a cure for cancer"  I will  also speak with Dr. Angela Waanders , who will talk about the importance of post mortem brain tissue donations, which could be a game changer in the future for pediatric brain cancer patients and their families.                                                                                                                                                                                 Advocating for these tissue donations is a major part of the Swifty Foundation which Michael was the inspiration behind, and which the Gustafson family run today as they are doing what they can to fight for these kids who receive such a difficult diagnosis. 

Taboo Topics
Pediatric Brain Cancer with Hannah Thomas

Taboo Topics

Play Episode Listen Later Feb 8, 2022 72:16


TW: cancer, mention of child death OH HEY! This is a decently special episode- it is actually the first one I ever recorded and the only one I recorded IN person. It was spur of the moment so the audio is a little off, but most of it is solid and of course, the content is important! PEDIATRIC BRAIN CANCER YO! Medulloblastoma! There are lots of organizations Hannah and I touch on, listed below! https://childrenwithhairloss.us/about-children-with-hair-loss/ https://fleeceandthankyou.org/ https://www.wishuponateen.org/ https://www.gktw.org/ and those stats- https://www.cancer.net/cancer-types/medulloblastoma-childhood

Help and Hope Happen Here
20 year old college sophomore Cole Eicher will discuss his diagnosis of Medulloblastoma when he was a 12 year old 6th grader, and the amazing advocacy work he has done for pediatric cancer since that time.

Help and Hope Happen Here

Play Episode Listen Later Feb 3, 2022 51:00


After an early childhood which included modeling and soccer, Cole Eicher was diagnosed with the Pediatric Brain Cancer Medulloblastoma when he was a 12 year old 6th grader.  As he entered the hospital , Cole noticed that there were many younger patients that were fighting their own cancer battles. He instinctively knew that this was not right and that he wanted to be a voice for these kids. So began the amazing advocacy work for so many children that Cole started  as a 12 year old while a patient himself,  and that this pediatric brain cancer survivor continues today. Cole will talk about setting up a meeting with American Cancer Society CEO Gary Reedy and  asked him to support the ideas that he had to help these children, including expanding the Relay For Life program . After Cole heard the word YES to his ideas , the Gold Together Non profit that he and his mom Laura started was well on its way.

Help and Hope Happen Here
Nancy Goodman will talk about her Non Profit KIDS V CANCER, which she started just 1 day after her son Jacob passed away from Medulloblastoma in 2009. Nancy will also speak about her successful initiatives that have been adopted on Capitol Hill

Help and Hope Happen Here

Play Episode Listen Later Nov 18, 2021 49:06


Just 1 day after her son Jacob passed away from Medulloblastoma in 2009, Nancy Goodman started the Non Profit KIDS V CANCER.  Nancy will discuss this non profit, whose objective it is to find new methods and medicines to help in the fight against Pediatric Cancer. Nancy is one of the leading advocates on Capitol Hill for these kids, and her advocacy has produced a number of initiatives along with legislation that has produced successful results and promises to produce even more successful results as time goes on.

Help and Hope Happen Here
Tamara Miles who lives in Sydney Australia, will talk about her son Bryson who is 5 years removed from his diagnosis of Medulloblastoma, and her son Ryder who is 3 1/2 years old, and has already undergone 18 brain surgeries.

Help and Hope Happen Here

Play Episode Listen Later Aug 30, 2021 51:38


Tamara Miles lives in Sydney Australia with her husband and 4 sons. Her son Bryson is now 8 years old and 5 years past his diagnosis of Medulloblastoma, and her son Ryder who is 3 1/2  has endured 18 brain surgeries, none of which had anything to do with Pediatric Cancer. Tamara will talk about what has been a very difficult journey for Bryson and Ryder, plus the emotional strain that has affected both her and her husband Grant. Tamara will also talk about the problems that the hospitals in Sydney and other places in Australia face , as the government cannot afford to give these hospitals the money that they need to do as much as they can for the cause of Pediatric Cancer. 

Help and Hope Happen Here
Ricardo Garcia is the co founder of the Biotech Company called Oncoheroes Biosciences. This company focuses exclusively on coming up with brand new drugs to help modernize treatments for Pediatric Cancer patients.

Help and Hope Happen Here

Play Episode Listen Later Aug 23, 2021 51:55


Ricardo Garcia's son Richi was diagnosed with high risk Medulloblastoma when he was 6 years old in 2011 and living in Spain. The Garcia family moved to Brookline, Ma. after the diagnosis and now 10 years later, after going through treatment at Boston Children's Hospital and Dana Farber, Richi is doing well and leading a good life. Ricardo will talk about Richi's cancer battle, the Richi Childhood Cancer Foundation that he started in 2013, and the Biotech company Onceoheroes Biosciences that he cofounded a few years ago, which is is 100 percent focused on developing new drugs that will help pediatric cancer patients in future years. 

Help and Hope Happen Here
Tatum Fettig will talk about her daughter Teagan's battle with Medulloblastoma and her ongoing recovery, as well as discussing the first nationwide non profit APP that helps parents of pediatric cancer patients communicate with each other.

Help and Hope Happen Here

Play Episode Listen Later Aug 19, 2021 55:41


Tatum Fettig will talk about her daughter Teagan and her battle with Medulloblastoma, which she was diagnosed with just after her 2nd birthday in December of 2016. Now 4  1/2 years later Teagen is doing well and is about to enter 1st grade .Tatum will also discuss the first non profit nationwide APP that she designed, which allows parents of pediatric cancer patients to communicate with one another. This APP has only been available since September of 2020 and promises to allow parents to take advantage of a whole new level of communication, as they meet their fellow peers who are going through the same or similar issues that they are experiencing themselves. 

Help and Hope Happen Here
Annette Leslie will talk about her son Carson's battle with Medulloblastoma, the book he wrote to help other patients which was published just 6 days before he passed away, and the Carson Leslie Foundation

Help and Hope Happen Here

Play Episode Listen Later Jul 29, 2021 56:38


Carson Leslie was diagnosed with Medulloblastoma at the age of 14 in 2006 and passed away from this Pediatric Brain Cancer in January of 2010. Carson wrote a book entitled CARRY ME which was published just 6 days before his passing, in the hope that his words would comfort other Pediatric Cancer patients who would inevitably suffer from some form of cancer.His mother Annette will talk about Carson's life, and the Carson Leslie Foundation which is helping to make great strides in many aspects of Medulloblastoma. Having the support of Texas Congressman Mike McCaul, the Cancer Prevention and Research Institute of Texas (CPRIT) which spends 12 percent of it's money on Pediatric Cancer while the average public money spent on this is only 4 percent, and the Jordan Spieth Foundation,  Annette is the engine that is making certain that there will be easier treatments, and easier paths towards a cure for these children and adolescents who have to endure such a difficult disease. 

Help and Hope Happen Here
Laura Eicher will talk about her son Cole's successful battle against Medulloblastoma, his amazing Pediatric Cancer volunteer activity at such a young age, and the Gold Together Initiative which both Laura and Cole play such a big role in.

Help and Hope Happen Here

Play Episode Listen Later Jul 19, 2021 56:43


When Cole Eicher was 12 years old he was diagnosed with Medulloblastoma, which is the most common form of Pediatric Brain Cancer. After an intense 9 month treatment, Cole recovered from this disease. He has spent the past 7 years advocating for children who have experienced all forms of Pediatric Cancer.At the age of 12 Cole decided that he wanted to be a voice for children and families facing childhood cancer. As a volunteer for the American Cancer Society he wanted to see a childhood cancer team at Relay For Life events nationwide. Cole knew that it would provide a way for children to be empowered and supported in their community. After a few years of testing, Gold Together became a national program with the American Cancer Society in November of 2018. His mother Laura will talk about Cole's mission to create more ways for people to volunteer and support courageous kids in their community.

Radiology Student
Paediatric neuroradiology(medulloblastoma)

Radiology Student

Play Episode Listen Later Dec 17, 2020 8:05


Immunology and Beyond
4. Pediatric Medulloblastoma and Bridging Industry with the Clinic with Dr. David Bakhshinyan

Immunology and Beyond

Play Episode Listen Later Nov 10, 2020 37:51


In this week's episode, Dr. David Bakhshinyan joins us to discuss his path through graduate studies and postdoctoral training in industry. Dr. Bakhshinyan defended his Ph.D. in Biochemistry at McMaster University, which explored the development of murine models to study tumor recurrence in Pediatric Medulloblastoma. We also discuss tips on choosing a laboratory, and how he plans to bridge academia, industry, and the clinic.  Twitter @immunoNbeyond & Insta @immunologyandbeyond

A.L.L. Mamma Care
Season 2 Ep. 13- Sara's Smiles

A.L.L. Mamma Care

Play Episode Listen Later Sep 14, 2020 41:37


Honestly, I’m not quite sure how to give my next guest Jen Burke a proper introduction. Jen is the President and founder of Saras Smiles. Her angel daughter Sara courageously underwent treatments for Medulloblastoma (a brain tumor) at the age of four. Heartbreakingly, she gained her wings less than a year after diagnosis but her memory still provides thousands of children smiles daily! It was an honor and a privilege to have some time to speak with Jen. I loved hearing about Sara, her interests and the special memories they share as mother and daughter. I’m truly in awe of Jen, what she’s created with Sara Smiles and what she provides for families like mine in memory of her daughter. Jen’s goal is to give kids fighting cancer as many smiles as possible and know they are not alone. My son, Ollie was a recipient of one of Sara Smiles Kits and we’re still exploring it! Stay tuned to learn how you can request one for your child too! Links: https://saras-smiles.org/ https://saras-smiles.org/kits/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/allmammacaretime/message Support this podcast: https://anchor.fm/allmammacaretime/support

On The air
Long-term Functional Effects of Medulloblastoma Treatment (Episode 95)

On The air

Play Episode Listen Later Jul 10, 2020 22:31


On this episode, second-year occupational therapy students Bailey Diprima, Serena Khiantani, and Pam Ponce talk about the outcome of their work in a course in OT school on evidence-based practice. Their study looked at the outcome of medical interventions used with children ages 4-18 for treatment of medulloblastoma, a malignant (cancerous) type of brain tumor that originates in the cerebellum. Their work on this project can be accessed via the following link: https://dc.uthsc.edu/mot2/6/ Bailey, Serena, and Pam are students in the Master's degree OT program at the University of Tennessee Health Science Center in Memphis, TN.

On The air
Long-term Functional Effects of Medulloblastoma Treatment (Episode 95)

On The air

Play Episode Listen Later Jul 10, 2020 22:31


On this episode, second-year occupational therapy students Bailey Diprima, Serena Khiantani, and Pam Ponce talk about the outcome of their work in a course in OT school on evidence-based practice. Their study looked at the outcome of medical interventions used with children ages 4-18 for treatment of medulloblastoma, a malignant (cancerous) type of brain tumor that originates in the cerebellum. Their work on this project can be accessed via the following link: https://dc.uthsc.edu/mot2/6/ Bailey, Serena, and Pam are students in the Master's degree OT program at the University of Tennessee Health Science Center in Memphis, TN.

PaperPlayer biorxiv neuroscience
Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity

PaperPlayer biorxiv neuroscience

Play Episode Listen Later May 2, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.30.068726v1?rss=1 Authors: Hwang, D., Dismuke, T., Tikunov, A., Rosen, E., Kagel, J., Ramsey, J., Lim, C., Zamboni, W., Kabanov, A., Gershon, T. R., Sokolsky-Papkov, M. Abstract: We report a novel, nanoparticle formulation of the SHH pathway inhibitor vismodegib that improves efficacy for medulloblastoma treatment while reducing toxicity. Systemic therapies for brain tumors are complicated by restricted blood-brain barrier (BBB) permeability and dose-limiting extraneural toxicity, therefore improved delivery approached are needed. Here we show how a nanoparticle delivery system addresses these obstacles, bringing new efficacy to previously ineffective therapy. Vismodegib has been a promising agent for patients with SHH-subgroup medulloblastoma and is FDA-approved for basal cell carcinoma. However, vismodegib has limited benefit for patients with SHH-driven medulloblastoma, due to off-target toxicities and the development of resistance during therapy. We encapsulated vismodegib in polyoxazoline block copolymer micelles (POx-vismo). We then evaluated POx-vismo using transgenic mice engineered to develop endogenous medulloblastomas, testing the novel agent in a preclinical model with native vasculature and tumor microenvironment. POx-vismo showed improved CNS pharmacokinetics and reduced systemic and bone toxicity. Mechanistic studies show that POx nanoparticles did not enter the CNS, but rather acted within the vascular compartment to improve drug delivery by decreasing drug binding to serum proteins and reducing the volume of distribution. POx-vismo demonstrated improved efficacy, extending the survival of medulloblastoma-bearing mice. Our results show the potential for a simple, non-targeted nanoparticle formulation to improve systemic brain tumor therapy, and specifically to enhance vismodegib therapy for SHH-driven cancers. Copy rights belong to original authors. Visit the link for more info

The Rare hour with Christopher Velona
Josh the super uncle!

The Rare hour with Christopher Velona

Play Episode Listen Later Mar 4, 2020 34:05


Joshua Ervasti, otherwise known as a super uncle. Listen today as Josh tells the story of one courageous little girl battling brain cancer and the sport that spiked a movement. Maddie Cunningham had Medulloblastoma at the age of three. This Horrible type of brain cancer attacks the cerebellum creating a very difficult life of cognitive loss and fine motor skills as well as balance. Through a loving family and a super uncle, they created Maddie Cunningham's classic volleyball Challenge to bring awareness and funds to help all children suffering from medulloblastoma. Maddie has been in remission for some time and is 17! To find out more and to contact Josh, please visit: http://www.maddysclassicvolleyball.com/ Facebook: http://www.facebook.com/MaddysClassicVolleyball Jervasti0824@gmail.com

Nameless Collaborative
4: Sara Stamp

Nameless Collaborative

Play Episode Listen Later May 16, 2019 30:16


Sara Stamp is Sara Stamp the author of a newly released book called The Other F-Word: When Faith Fills the Gap. Sara is also the Executive Director of Layla’s Legacy Foundation, an organization created to raise money for innovative pediatric brain cancer research while also bringing hope and help to families impacted by the disease. Sara founded Laya’s Legacy with her husband Bryan after losing their 5-year-old daughter, Layla, to Medulloblastoma, which is the most common form of pediatric brain cancer. https://sarastamp.com/http://laylaslegacy.org/https://womensnpa.org/

Epigenetics Podcast
Cancer and Epigenetics (David Jones)

Epigenetics Podcast

Play Episode Listen Later Oct 31, 2017 32:44


Cancer has become one of the most dangerous diseases of the aging population of industrialized countries. Finding tools to fight cancer is hard, because Cancer presents itself as highly heterogeneous, with over 100 types of cancers described. Not only does Cancer affect aged humans, it has been observed in children in the form of e.g. Medulloblastoma. In the third episode of Active Motif's Epigenetics Podcast, our host Dr. Stefan Dillinger sits down with Dr. David Jones, group leader at the German Cancer Research Center in Heidelberg, to talk about his research on Medulloblastoma and also the emerging role of epigenetic factors in Cancer. References for this episode Alioto, Ivo Buchhalter, … Ivo G. Gut. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nature Communications. 2015 Dec 9; 6, Article number: 10001 doi:10.1038/ncomms10001 David TW Jones, Natalie Jäger, … Peter Lichter. ICGC PedBrain: Dissecting the genomic complexity underlying medulloblastoma. Nature. 2012 Aug 2; 488(7409): 100–105. doi:10.1038/nature11284 Jeremy Schwartzentruber, Andrey Korshunov, … Nada Jabado. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012 Feb 9; 482, 226–231 doi:10.1038/nature10833 Active Motif Contact Details Follow Active Motif on Twitter Follow our Epigenetics Podcast on Twitter Join us on LinkedIn Like us on Facebook Email us @Active Motif Europe or Active Motif North America.

American Snippets with Barb Allen & Dave Brown
E015 - Mia’s Might - A Young Cancer Survivor’s Mission to Pay it Forward

American Snippets with Barb Allen & Dave Brown

Play Episode Listen Later Sep 14, 2017 20:23


Mia Dede doesn’t look like a typical warrior. This beautiful young girl with a huge smile and endearing shyness does not look like she was ever anything but happy. She was just two years old when her mother rushed her to the emergency room. It was Mother’s Day, and Cynthia Diaz should have been simply enjoying the day, but Mia “could barely stand still without falling” and Cynthia knew there was something seriously wrong with her daughter. Mia was diagnosed with Medulloblastoma a Brain tumor. She lived in a hospital for 7 months undergoing 6 cycles of high dose chemotherapy and finally recovered from the final stage in her treatment - a stem cell transplant. Today, Mia is a healthy 10 year-old girl that is lucky to never have had to spend another night in the hospital since treatment ended. Now, this young cancer survivor is making sure other kids like her find some brightness in their darkest days. If you enjoyed this episode, check out the featured article, video, and more at americansnippets.com/015

BTW 2016
Revisiting intrathecal therapy for childhood medulloblastoma

BTW 2016

Play Episode Listen Later Aug 14, 2017 10:14


Prof Walker talks to ecancertv at Children with Cancer UK’s workshop on Drug Delivery in Paediatric Brain Tumours in London, UK. In the interview he discusses the use of intrathecal therapy in children with medulloblastoma. In particular he discusses the findings of a literature review looking at the range of drugs that may be suitable for intrathecal administration. The analysis found 126 candidate drugs of which only 12 were selected as eligible for further clinical investigation at this point. A further 15 were thought probably for further pre-clinical investigation.

NCRI 2016
Therapeutic targeting of childhood medulloblastoma

NCRI 2016

Play Episode Listen Later Aug 2, 2017 6:47


Dr Singh speaks with ecancertv at NCRI 2016 about the pathways through which cancer stem cells drive tumourigenesis and subvert treatments, in the specific setting of medulloblastoma. She describes research with patient-derived xenograft models to modify treatment regimens, giving insight into opportunities to avoid the systemic toxicities associated with current therapies.

Lose the Cape! Moms who want to change the world
Sara O’Neal Stamp – Live Bravely ep 101

Lose the Cape! Moms who want to change the world

Play Episode Listen Later Jul 24, 2017 42:00


In this episode, we talked about: How they discovered her daughter’s brain cancer in October 2016.How quickly they acted between diagnosis to surgery (less than 24 hours).Medulloblastoma is the leading cause of childhood brain cancer.Her daughter’s tumor reoccurrence in different areas of her brain and spine just a few months after her treatment ended.The way her family has changed their norm for this summer to give Layla as much fun as possible!Money, insurance and starting a GoFundMe.The support of case workers and oncologists who advocate for your child alongside you.All of the stresses that families with medical hardship suffer in addition to the stress of hospital stays.Their current fundraiser, a golf tournament and the story behind it.Becoming a part of another foundation, Carson Leslie Foundation. 

Mouse Genetics 2017
D. Marazziti - Mouse mutant models of cerebellum development and medulloblastoma

Mouse Genetics 2017

Play Episode Listen Later Apr 3, 2017 26:18


Daniela Marazziti, BCN-CNR, Monterotondo, Italy speaks on "Mouse mutant models of cerebellum development and medulloblastoma". This movie has been recorded at ICGEB Trieste.

The Lancet Oncology
Medulloblastoma: The Lancet Oncology: March 11, 2016

The Lancet Oncology

Play Episode Listen Later Mar 12, 2016 9:57


Michael Taylor discusses treatment approaches to the rare brain tumour that generally affects children, medulloblastoma.

Understanding Childhood Cancer With Dr Geoff

Medulloblastoma is the commonest malignant brain tumour in childhood. This podcast describes the investigations and treatment of medulloblastoma.

This Week in Pediatric Oncology
TWiPO #8 ~ Seneca Valley virus and medulloblastoma

This Week in Pediatric Oncology

Play Episode Listen Later Feb 10, 2014 18:56


June 09, 2011 An oncolytic virus for a common childhood brain tumor In this eighth episode of "This Week in Pediatric Oncology" podcast hosts Dr. Tim Cripe, Dr. Lars Wagner and Dr. Lionel Chow discuss a recent publication by researchers at Baylor/Texas Children's in Houston that shows remarkable results of Seneca Valley virus SVV-001 on orthotopic mouse models of medulloblastoma. The TWiPO hosts raise many interesting points about this research and highlight the strengths as well as limitations of this work. This exciting research provides new evidence of promise for oncolytic virus therapy for childhood tumors. For more information about oncolytic virus trials for pediatric cancers, see a recent webinar "Oncolytic Virotherapy for Pediatric Solid Tumors" presented by the principal investigators of five clinical trials in children and sponsored by Solving Kids' Cancer. The article discussed in this episode can be found here: A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Yu L, Baxter PA, et al. Neuro Oncol. 2011 Jan;13(1):14-27. Epub 2010 Nov 12. Another related article by the same group: Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. Wadhwa L, Hurwitz MY, et al. Cancer Res. 2007 Nov 15;67(22):10653-6. [fulltext] Please send questions or comments to twipo@solvingkidscancer.org

Journal of Clinical Oncology (JCO) Podcast
Benefits of Modified Craniospinal Radiation Therapy for Children Treated for Medulloblastoma: Preserving Long-Term Neurocognitive Function

Journal of Clinical Oncology (JCO) Podcast

Play Episode Listen Later Feb 10, 2014 8:22


Children treated for medulloblastoma using reduced dose craniospinal radiation with local tumor bed boost have improved neurocognitive outcomes compared with conventional therapy, pointing to an opportunity for prevention of severe late effects by treatment modification.

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19
The role of β1-Integrin in the cerebellar development and the formation of medulloblastoma

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19

Play Episode Listen Later Jan 24, 2013


Thu, 24 Jan 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/15294/ https://edoc.ub.uni-muenchen.de/15294/1/Frick_Alexandra.pdf Frick, Alexandra ddc:610, ddc:600,

McMaster Demystifying Medicine Seminar Series

Learning Objective: To review the current management and treatment of childhood medulloblastoma To understand the clinical implications of medulloblastoma from a patient's point of view To discuss recent evidence for the presence of a medulloblastoma stem cell that drives tumorigenesis in this malignant childhood tumor. To understand how developmental signaling pathways may be aberrantly activated to cause this childhood brain tumour.

McMaster Demystifying Medicine Seminar Series

Learning Objectives: To review the current management and treatment of childhood medulloblastoma To understand the clinical implications of medulloblastoma from a patient's point of view To discuss recent evidence for the presence of a medulloblastoma stem cell that drives tumorigenesis in this malignant childhood tumor. To understand how developmental signaling pathways may be aberrantly activated to cause this childhood brain tumour.

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19
The role of the transcription factor BARHL1 in medulloblastoma

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19

Play Episode Listen Later Dec 1, 2011


Das Medulloblastom ist der häufigste maligne Hirntumor des Kindesalters, und die Entwicklung von zielgerichteten, nebenwirkungsarmen Therapiestrategien hat oberste Priorität. Die molekularen Mechanismen der malignen Transformation dieses Tumors sind noch nicht bis ins Letzte verstanden, jedoch ist bekannt, dass Medulloblastome von Körnerzellvorläufern abstammen können. Barhl1 ist einer der Transkriptionsfaktoren, die das Überleben und die Migration von Körnerzellvorläufern steuern, jedoch ist die Funktion, die Barhl1 im Medulloblastom hat, noch unbekannt. Diese Arbeit zeigt, dass die Expression von BARHL1 während der Entwicklungsphase des menschlichen Kleinhirns und in humanen Medulloblastomen im Vergleich zu Kleinhirnen von Erwachsenen signifikant hochreguliert ist. Hohe Barhl1 Expressionslevel wurden zudem in Medulloblastomen von Math1-cre:SmoM2Fl/+ Mäusen gefunden, welche ein bewährtes Mausmodel für Sonic hedgehog-assoziierte Medulloblastome darstellen, die von cerebellären Körnerzellvorläufern abstammen. Um die Funktion von Barhl1 in vivo während der Entwicklung und des Wachstums von Medulloblastomen zu untersuchen, wurden Barhl1-/- Math1-cre:SmoM2Fl/+ und Barhl1+/-Math1-cre:SmoM2Fl/+ Mäuse generiert. Interessanterweise zeigten Tumoren, die in diesen Mäusen entstanden, eine vermehrte mitotische Aktivität und eine verminderte neuronale Differenzierung. Zudem war das Überleben dieser Mäuse im Vergleich zu dem von Math1-cre:SmoM2Fl/+ Mäusen signifikant verkürzt. Im Einklang mit diesen Ergebnissen zeigten Patienten, deren Medulloblastom eine niedrige BARHL1 Expression aufwies, eine schlechtere Prognose als Patienten, deren Tumoren eine höhere BARHL1 Expression aufwiesen. Diese Ergebnisse deuten darauf hin, dass die Expression von Barhl1 das Tumorwachstum in murinen und humanen Medulloblastomen verlangsamt. Deswegen sollte BARHL1 im Hinblick auf potentielle Anwendungen für individualisierte therapeutische Strategien weiter untersucht werden.

University of Alabama at Birmingham Radiation Oncology

Fri, 05 Sep 2008 16:23:15 GMT https://www.screencast.com/users/RadOnc/folders/University+of+Alabama+at+Birmingham+Radiation+Oncology/media/1bf2fb04-e3bc-40a7-81ac-ec081f1c4eb5 https://www.screencast.com/users/RadOnc/folders/University+of+Alabama+at+B