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Peripheral artery disease has been called the ‘silent circulatory crisis'—affecting millions, limiting mobility, and quietly raising the risk of heart attack, stroke, and limb loss. For decades, treatment focused on walking programs, aspirin, and sometimes a stent or bypass. But today, the landscape is changing. From PCSK9 inhibitors that drive cholesterol to record lows, to GLP-1 agonists like semaglutide improving walking distance, to novel antithrombotic strategies that balance bleeding and clotting—PAD care is entering a new era. In this episode, we'll explore the breakthroughs, the evidence behind them, and what they mean for patients who just want to keep moving forward." Hosted by the University of Michigan Department of Vascular Surgery: - Robert Beaulieu, Program Director - Frank Davis, Assistant Professor of Surgery - Luciano Delbono, PGY-5 House Officer - Andrew Huang, PGY-4 House Officer - Carolyn Judge, PGY-2 House Officer Learning objectives: 1. Describe the current evidence-based recommendations for multifactorial medical management of peripheral artery disease (PAD), including lipid, glycemic, and antithrombotic strategies per 2024 SVS/AHA guidelines. 2. Interpret the clinical implications of the FOURIER trial regarding the role of PCSK9 inhibition in reducing cardiovascular events in patients with atherosclerotic disease, including PAD. 3. Evaluate the emerging role of GLP-1 receptor agonists, such as semaglutide, in improving walking performance and quality of life among patients with diabetic PAD based on findings from the STRIDE trial. Sponsor URL: https://www.goremedical.com/ References: H. L. Gornik et al., “2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease,” JACC, vol. 83, no. 24, pp. 2497–2604, June 2024, doi: 10.1016/j.jacc.2024.02.013. L. Mazzolai et al., “2024 ESC Guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM),” Eur Heart J, vol. 45, no. 36, pp. 3538–3700, Sept. 2024, doi: 10.1093/eurheartj/ehae179. https://pubmed.ncbi.nlm.nih.gov/40169145/ M. S. Sabatine et al., “Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease,” N Engl J Med, vol. 376, no. 18, pp. 1713–1722, May 2017, doi: 10.1056/NEJMoa1615664. https://pubmed.ncbi.nlm.nih.gov/28304224/ M. P. Bonaca et al., “Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial,” Lancet, vol. 405, no. 10489, pp. 1580–1593, May 2025, doi: 10.1016/S0140-6736(25)00509-4. https://pubmed.ncbi.nlm.nih.gov/40169145/ N. E. Hubbard, D. Lim, and K. L. Erickson, “Beef tallow increases the potency of conjugated linoleic acid in the reduction of mouse mammary tumor metastasis,” J Nutr, vol. 136, no. 1, pp. 88–93, Jan. 2006, doi: 10.1093/jn/136.1.88. https://pubmed.ncbi.nlm.nih.gov/16365064/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: 5 Ways to Predict Mortality (NO BLOOD TEST REQUIRED). (2:27) Good and bad news for young men. (22:20) Reducing your calories without eating less by going grass-fed. (35:26) Runit is invading America. (40:16) Speaking identity into your children. (45:12) Sal has an athlete on his hands. (49:58) LMNT has single-handedly created this new electrolyte market. (52:49) #ListenerCoaching call #1 – I train hard and feel great, but I don't feel like it's translating to everyday life. What am I missing? (55:29) #ListenerCoaching call #2 – Needing some advice on my current aggressive fat loss and body recomposition journey. (1:07:55) #ListenerCoaching call #3 – What's your typical recommended rest between sets? (1:17:50) #ListenerCoaching call #4 – Needing guidance on my fitness path and seeking advice on training, macros, and whether you offer personal training. (1:25:08) Related Links/Products Mentioned Get Coached by Mind Pump, live! Visit https://www.mplivecaller.com Visit Butcher Box for this month's exclusive Mind Pump offer! ** New users receive their choice of NY Strip, Ribeye, or Filet Mignon in every box for a year. ** Get a free Sample Pack of LMNT's most popular drink mix flavors with any purchase! As always, LMNT offers no-questions-asked refunds on all orders. The 8-count LMNT Sample Pack doubles down on our most popular flavors: Citrus Salt, Raspberry Salt, Watermelon Salt, and Orange Salt (2 stick packs of each flavor): Visit DrinkLMNT.com/MindPump MAPS 15 Symmetry 50% off! ** Code DECEMBER50 at checkout. ** Mind Pump Store Can a 10-second balance test predict longevity? - Harvard Health Sit-to-stand: The simple test that reveals how you're ageing A brief fitness test may predict how long you'll live Push-Ups and Heart Health: What Your Fitness Level Says About Your Risk HANDGRIP DYNAMOMETER Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies 45 Percent of Guys 18-25 Have Never Asked a Girl Out in Person Australian collision sport Runit makes U.S. debut with stops in SoCal Rosenthal Effect: How Expectations Shape Reality Fig and Eagle Visit Luminose by Entera for an exclusive offer for Mind Pump listeners! ** Code MPM at checkout for 10% off their order or 10% off their first month of a subscribe-and-save. ** Mind Pump #2411: How to Know You are Overtrained & Underfed, Why You May Not Feel Low Testosterone, How to Properly Cut & More (Listener Live Coaching) Mind Pump #2690: The NEW DIET Everyone Is Using For Fat Loss Mind Pump #1612: Everything You Need to Know About Sets, Reps & Rest Periods Mind Pump #2759: Progressive Overload, the Secret to Building Muscle and Burning Fat. Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Adam | Relationship Psychology (@attachmentadam) Instagram Scott Donnell (@imscottdonnell) Instagram Mind Pump Fitness Coaching (@mindpumppersonaltraining) Instagram
What do you think of thiamine as a treatment for Parkinson's?Is there a natural thyroid medicine you recommend that is not pork-derived?Please discuss the COVID-19 vaccine and cardiology issuesCan you help my granddaughter with guttate psoriasis?
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Dr. Hoffman continues his conversation with Dr. Jeffrey Bland, founder and president of the Personalized Lifestyle Medicine Institute and Big Bold Health.
Dr. Jeffrey Bland, founder and president of the Personalized Lifestyle Medicine Institute and Big Bold Health, discusses his significant influence on functional medicine and offers a deep dive into the history and benefits of fish oil, including its impact on cardiovascular health, inflammation, and immune system resilience. Dr. Bland elaborates on the necessity of balanced Omega-3 fatty acids, particularly EPA and DHA, and the unique benefits of cold-processed fish oils that retain natural nutrients. The conversation also touches on Big Bold Health's innovative approach to health through products like Omega-3 Rejuvenate and Himalayan Tartary Buckwheat, highlighting their roles in promoting immune health. The episode underscores the importance of sustainability and the dedication of farmers and fishermen in producing high-quality, health-supportive products.
Join Dr. Grace Chua and Dr. Akshay Jain as they unpack the complex relationship between obesity and cardiovascular disease (CVD). In this episode, they explore the pathophysiologic mechanisms linking obesity to CVD, including the roles of insulin resistance, chronic inflammation, and visceral adiposity. The discussion also highlights clinical implications for early risk identification and patient stratification, helping clinicians better recognize and address cardiovascular risk. This podcast is part of the Obesity and CVD Knowledge Mobilization Strategy, an initiative designed to equip healthcare providers with practical tools and evidence to address obesity as a major driver of cardiovascular disease.
Popular media leverage weak study to criticize RFK Jr.'s rethink of standard recommendations for saturated fat avoidance; Poor quality plant-based diets hike cardio risk; A listener complains his lp(a) is going up with age despite his healthy diet, lifestyle; Scientists pinpoint cocoa ingredient that slows aging; Berry proanthocyanidins preserve brain power; Tattooing may promote inflammation, undermine immunity.
19th ACC 2025 Congress Coverage: HPV Infection and Cardiovascular Disease
We are in our 3rd week of our 4-part series on the #1 killer in America. And we're talking about the Diagnostics that Dr. Prather uses to get to the root cause of Cardiovascular Disease. In this episode, you'll learn:—How Diagnostics are "even more important and more complete" in the Structure-Function Health Care model than in Disease Care.—Why the electrical system of the Heart is so important. And how Dr. Prather uses what he considers "the best" in Holter monitors to measure a patient's electrical system.—The way a patient's EKG will completely normalize though the therapeutic exercise External CounterPulsation (ECP) Therapy at Holistic Integration .—The impact of the Nervous System on the Heart's electrical system, which can be improved through Chiropractic care. And the way Holistic Integration measures the Vagus Nerve and the Parasympathetic and Sympathetic balance through their Autonomic Nervous System (ANS) Test. —Why Minerals are "critical" to the electrical system of the Heart. And how Minerals are best measured through Hair Analysis and Bloodwork. —The amazing story of the patient whose WATCH was throwing off his heart's electrical system. —How Dr. Prather sees many Heart problems cleared up by clearing Heavy Metals out of people.—Why getting to the root cause of a patient's Heart problem is "like detective work". —The link between infections and Cardiovascular Disease, such as the Coxsackie B virus which can cause Cardiomyopathy. And how infections, most commonly Strep, can also cause Heart Valve Issues.—How the Heart CAN be healed and has an amazing ability to regenerate.http://www.TheVoiceOfHealthRadio.com*Receive exclusive bonus content as a member of our Voice Of Health Patreon Community:https://www.patreon.com/cw/VoiceofHealthPodcast
Welcome to part two of our Best of 2025 series - the moments that changed how our listeners think about their health and what they do on a day-to-day basis. In this episode, we delve into simple questions with profound impact. Is it safe to experiment with your own health? Does cheese really cause bad dreams? Why do some breakfasts leave you tired and hungry, while others don't? If you're looking for practical, science-led ideas you can take into the year ahead, this episode brings together the insights listeners found most useful, surprising, and worth returning to. Unwrap the truth about your food
Chegou o episódio escolhido por vocês! Marcela Belleza e Joanne Alves convidam Carol Millon para conversar sobe 6 clinicagens de inibidores de SGLT2, as gliflozinas:Indicações além do DMRisco de CAD euglicêmicaQuando não usar?Cuidados com doença aguda (sick day) e hipovolemiaCuidados pré-operatórioRisco de fratura e amputaçãoReferências:1. Bailey CJ, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43. Published 2013 Feb 20. doi:10.1186/1741-7015-11-432. Bersoff-Matcha SJ, et al. Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med. 2019;170(11):764-769. doi:10.7326/M19-00853. Chang HY, et al. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes. JAMA Intern Med. 2018;178(9):1190-1198. doi:10.1001/jamainternmed.2018.3034 4. Clar C, et al. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open. 2012 Oct 18;2(5):e001007. doi: 10.1136/bmjopen-2012-001007. PMID: 23087012; PMCID: PMC3488745.5. Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5. PMID: 32771263; PMCID: PMC7545583. 6. Fralick M, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. Published 2020 Aug 25. doi:10.1136/bmj.m28127. Li D, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19(3):348-355. doi:10.1111/dom.128258. Neal B, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-223.e11. doi:10.1016/j.ahj.2013.05.0079. Nyirjesy P, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-1178. doi:10.1185/03007995.2012.69705310. Perkovic V, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. doi:10.1056/NEJMoa181174411. Rosenwasser RF, et al. SGLT-2 inhibitors and their potential in the treatment of diabetes. Diabetes Metab Syndr Obes. 2013 Nov 27;6:453-67. doi: 10.2147/DMSO.S34416. PMID: 24348059; PMCID: PMC3848644.12. Sridharan K, Sivaramakrishnan G. Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Opin Drug Saf. 2025;24(7):797-804. doi:10.1080/14740338.2024.237775513. Ueda P, et al. Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study. BMJ. 2018;363:k4365. Published 2018 Nov 14. doi:10.1136/bmj.k436514. Watts NB, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 Jan;101(1):157-66. doi: 10.1210/jc.2015-3167. Epub 2015 Nov 18. PMID: 26580237; PMCID: PMC4701850.15. Zhuo M, et al. Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fracture Risk in Older Adults With Type 2 Diabetes. JAMA Netw Open. 2021;4(10):e2130762. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.3076216. Emerson Cestari Marino, Leandra Anália Freitas Negretto, Rogério Silicani Ribeiro, Denise Momesso, Alina Coutinho Rodrigues Feitosa, Marcos Tadashi Kakitani Toyoshima, Joaquim Custódio da Silva Junior, Sérgio Vencio, Marcio Weissheimer Lauria, João Roberto de Sá, Domingos A. Malerbi, Fernando Valente, Silmara A. O. Leite, Danillo Ewerton Oliveira Amaral, Gabriel Magalhães Nunes Guimarães, Plínio da Cunha Leal, Maristela Bueno Lopes, Luiz Carlos Bastos Salles, Liana Maria Torres de Araújo Azi, Amanda Gomes Fonseca, Lorena Ibiapina M. Carvalho, Francília Faloni Coelho, Bruno Halpern, Cynthia M. Valerio, Fabio R. Trujilho, Antonio Carlos Aguiar Brandão, Ruy Lyra e Marcello Bertoluci. Rastreamento e Controle da Hiperglicemia no Perioperatório – Posicionamento Conjunto da Sociedade Brasileira de Diabetes (SBD), Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica (ABESO). Diretriz Oficial da Sociedade Brasileira de Diabetes (2025). DOI: 10.29327/5660187.2025-10 , ISBN: 978-65-5941-367-6.17. Singh LG, Ntelis S, Siddiqui T, Seliger SL, Sorkin JD, Spanakis EK. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2024;47(6):933-940. doi:10.2337/dc23-112918. Mehta PB, Robinson A, Burkhardt D, Rushakoff RJ. Inpatient Perioperative Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter-2 Inhibitors - Lessons From a Case Series and Strategies to Decrease Incidence. Endocr Pract. 2022;28(9):884-888. doi:10.1016/j.eprac.2022.06.00619. Umapathysivam MM, Morgan B, Inglis JM, et al. SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Netw Open. 2024;7(3):e242744. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.274420. Fleming N, Hamblin PS, Story D, Ekinci EI. Evolving Evidence of Diabetic Ketoacidosis in Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors. J Clin Endocrinol Metab. 2020;105(8):dgaa200. doi:10.1210/clinem/dgaa20021. Neuen BL, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2019;7(11):845-854. doi:10.1016/S2213-8587(19)30256-622. Braunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med. 2022;386(21):2024-2034. doi:10.1056/NEJMra211501123. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa150472024. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-657. doi:10.1056/NEJMoa161192525. Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380(4):347-357. doi:10.1056/NEJMoa181238926. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa191130327. Packer M, Anker SD, Butler J, et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413-1424. doi:10.1056/NEJMoa202219028. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa210703829. Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi:10.1056/NEJMoa202481630. The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, et al. Empagliflozin in...
Cardiovascular-Kidney-Metabolic (CKM) Syndrome leads to poor health outcomes, and is affecting individuals at younger and younger ages. The PREVENT calculator helps identify individuals earlier in the disease progression, allowing time for intervientions that may lead to a regression on the stages of CKM. Guest Chiadi Ndumele, MD, PhD. also describes shared decision-making, and value- and volume-based care models.PREVENT calculator: https://professional.heart.org/en/guidelines-and-statements/prevent-calculatorPooled 10-year ASCVD Risk Calculator: https://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate/ 2025 Hypertension Guidelines Update: https://www.heart.org/en/health-topics/high-blood-pressure/the-facts-about-high-blood-pressure/high-bp-top-10AHA CKM Scientific Statement: https://professional.heart.org/en/science-news/cardiovascular-kidney-metabolic-health-a-presidential-advisoryPCNA CKM Resource list: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Commentary by Dr. Jian'an Wang.
Send us a message with this link, we would love to hear from you. Standard message rates may apply. In this episode of Your Checkup, we break down lipoprotein(a) — a largely inherited form of cholesterol that can significantly increase the risk of heart disease and stroke, even when standard cholesterol numbers look normal. We talk about what Lp(a) is, why it matters, who should be tested, and how it helps explain “unexpected” heart events in otherwise healthy people. While Lp(a) can't currently be lowered with diet or exercise, knowing your level allows you and your care team to be more intentional about prevention by aggressively managing other risk factors like LDL cholesterol, blood pressure, and diabetes. We also discuss what the numbers mean, why most people only need to be tested once, and the promising treatments currently being studied that may change care in the future. References (for Show Notes)Nordestgaard BG, Langsted A. Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024;404(10459):1255-1264.Reyes-Soffer G, et al. AHA Scientific Statement on Lipoprotein(a). Arterioscler Thromb Vasc Biol. 2022;42(1):e48-e60.Di Fusco SA, et al. Lipoprotein(a): Risk Factor and Emerging Target. Heart. 2022;109(1):18-25.Nasrallah N, et al. Lp(a) in Clinical Practice. Eur J Clin Invest. 2025:e70127.Greco A, et al. Lipoprotein(a) as a Pharmacological Target. Circulation. 2025;151(6):400-415.Bess C, Mehta A, Joshi PH. All We Need to Know About Lipoprotein(a). Prog Cardiovasc Dis. 2024;84:27-33.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski
We are in week 2 of a 4-part series on the #1 killer in America. And our focus this week is on Holistic Treatments for Cardiovascular Disease In this episode, we talk about:—How a shift to the left of the Thoracic spine indicates heart problems, which can often be reversed once everything is aligned properly. —The number one treatment for every kind of Cardiovascular Disease. And the External CounterPulsation (ECP) Therapy that produces even better results than doing aerobic exercise.—Why Dr. Prather gets even better patient results than expected by the researchers of ECP Therapy. And the importance of proper nutritional supplementation alongside ECP Therapy "that does miracles". —How ECP Therapy helps fight aging, keeps the brain working better, and improves oxygenation to all the organ systems of the body. And Dr. Prather's own story of how ECP Therapy has helped his heart heal from damage caused by a spider bite. —Why the combination of ECP Therapy and proper nutrients produces great results for patients suffering from Congestive Heart Failure, with hearts twice the normal size going completely back to normal after 7 weeks.—How you'd look like you were 21 for the rest of your life if you had no Free Radical damage, which causes Cataracts, Macular Degeneration, age or Liver spots, Cancer cells, Cardiovascular damage, and Dementia. —The "critical" importance of Minerals for Heart health. And how Dr. Prather can tell which mineral deficiencies a patient has just by looking at their EKG. —How Holistic Integration can actually test which Vitamins, Minerals, and Amino Acids that will work best for the patient. —Why Dr. Prather calls Homeopathy "our secret weapon". And how most Medical Doctors don't realize that Nitroglycerin is actually a homeopathic. —The "immediate" changes in the EKG that Dr. Prather often sees after a patient receives a Chiropractic adjustment. And the power of Acupuncture in reducing inflammation and increasing the healing ability of the body internally. http://www.TheVoiceOfHealthRadio.com*Receive exclusive bonus content as a member of our Voice Of Health Patreon Community:https://www.patreon.com/cw/VoiceofHealthPodcast
Joanne Mitchell-McLaren is a Lifelong Patient Advocate and Educator, Clinical Expert and Rare Disease Specialist. Her overall goal is to prepare and provide patients and caregivers with the awareness, support and education they need as it relates to their health. She has provided tools, education and encouragement that patients need to feel confident to have courageous conversations with their health care providers; in hopes to empower them to make the best decision and to use their voice to advocate for themselves.Patient advocacy is her birth right. She believe the greatest gift one can provide is the gift of a servant, especially to those with vulnerabilities in our community regardless of their diagnosis, neighborhood one resides in or any other health disparity reason.
First shots fired in war against ultra-processed foods; What the big reveal of Trump's MRI really shows; Is cruelty to horses really necessary to make estrogen? Early smartphone use linked to mental harms in kids; Nutritionist sues American Diabetes Association for forcing her to promote unhealthy artificial sweeteners; Halle Berry dings California Governor Newsom for vetoing menopause awareness bill.
This week, we kick off a 4-part series on the #1 killer in America by talking about the problem of Cardiovascular Disease. In this episode, you'll discover:—How Cardiovascular Disease was identified as the #1 killer back in the 1950's and is STILL the #1 killer today, which Dr. Prather says "raises some questions".—The two top competing theories about the underlying cause of Heart Disease among researchers back in the 1970's. And why Dr. Prather believes the winning theory of Cholesterol as the main cause is wrong.—The dangerous side effects of anti-cholesterol Statin drugs and why patients come to Dr. Prather seeking alternatives. —How Cholesterol is in our bodies for healing and is "there to save your life". And the connection between those who live over the age of 100 and an overall Cholesterol level of 300.—The Cardiac C-Reactive Protein Test that is "probably the best indicator of whether you're going to have a heart attack or not". —The four main things Dr. Prather says are the real cause of Cardiovascular Disease: Inflammation, Oxygenation and Nutrient Deprivation, Electrical Conduction Disruption from Nerve and Mineral Issues, and Food Allergies.—How Inflammation is the cause of Vascular Disease. And how that Inflammation increases when you try to "artificially" lower Cholesterol levels. —Why the Coxsackie B Virus is so prevalent in Indianapolis and can lead to Cardiovascular Disease. —How the Atlas Orthogonal Chiropractic Adjustment can have a bigger effect on Hypertension than Prescription High Blood Pressure Medication. —Why Dr. Prather says "the heart can actually regenerate in an amazing type of way" and that he did not even expect to see the things he has seen in his office with all the positive changes in patients. http://www.TheVoiceOfHealthRadio.comReceive exclusive bonus content as a member of our Voice Of Health Patreon Community:https://www.patreon.com/cw/VoiceofHealthPodcast
The best water filter?Even more on gadoliniumVagus nerve therapy benefitsWith so many benefits of drinking coffee, should I drink more of it instead of tea?Any update on Barrett's Esophagus?
Nutritional strategies for treating Barrett's EsophagusHow can my uncle mitigate the side effects of his Merkel cell carcinoma therapy?How long can I take strontium?Is beet root powder beneficial for nitric oxide production?
Afib is on the rise with significant effects on morbidity and mortality. The stagnation of blood in the left atrium and left atrial appendage (LAA) places patients at risk for thromboembolism and stroke. By ligating or closing off the LAA, the risk can be significantly reduced. This intervention offers a valuable alternative to medication, improving safety and quality of life for patients through a minimally invasive, durable stroke prevention strategy. Learn more about the procedure and steps for referring your eligible patient. https://chads2vasccalculator.com/https://www.watchman.com/en-us-hcp/oac-alternative.html?utm_source=oth_site&utm_medium=display-direct&utm_campaign=ic-wm-us-dtr-hcp_app&utm_content=pcna_podcast_oac_alternative-n-n-n&cid=dsp10020937https://www.watchman.com/en-us-hcp/patient-selection-referrals/patient-pre-screening-tool.html?utm_source=oth_site&utm_medium=display-direct&utm_campaign=ic-wm-us-dtr-hcp_app&utm_content=pcna_podcast_patient_screener-n-n-n&cid=dsp10020938https://pcna.net/resource/afib-prepare-for-your-next-visit-discussion-guide/https://pcna.net/resource/the-beat-goes-on-living-with-atrial-fibrillation-online-interactive-patient-guide/https://pcna.net/resource/afib-and-stroke-infographic/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Afib is on the rise with significant effects on morbidity and mortality. Afib is a progressive disease with various treatment methods to match to your patients' risk factors and health goals. Stroke prevention is a crucial risk factor to evaluate on the progressive journey of a patient experiencing Afib. Learn more about the assessment and identification of patients with Afib at risk for stroke and next steps in prevention.https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193https://chads2vasccalculator.com/https://www.uptodate.com/contents/image?imageKey=HEME%2F75259https://pcna.net/resource/afib-prepare-for-your-next-visit-discussion-guide/https://pcna.net/resource/the-beat-goes-on-living-with-atrial-fibrillation-online-interactive-patient-guide/https://pcna.net/resource/afib-and-stroke-infographic/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In the December 2, 2025 episode of JACC This Week, Editor-in-Chief Harlan M. Krumholz, MD, SM, introduces the Spotlight Issue, anchored by the manuscript "Global, Regional, and National Burden of Cardiovascular Disease and Risk Factors in 204 Countries and Territories, 1990–2023." Listen here as he reviews the issue and gives listeners perspective on the issue as a whole, which contains 19 viewpoints providing perspectives from experts around the world, plus his editor's page, aligned with a talk given at the UN with JACC Editor Emeritus Valentin Fuster, MD, and author Gregory A. Roth, MD. Other perspectives include: CVD in Sub-Saharan Africa; access to essential medicines and technologies; confronting inequities in pediatric cardiac care; and perspectives from Japan, Canada, the Middle East & North Africa, South America, Pakistan, and many others. Listen to the podcast and then check out the full issue online here: https://www.jacc.org/toc/jacc/86/22.
Clinical Pharmacist, Author, Board-Certified Clinical Nutritionist, and Health Expert Jim LaValle details the many health benefits of aged garlic extract, particularly its impact on periodontal disease. He reveals exciting new research findings that show Kyolic Aged Garlic Extract supplements can significantly reduce periodontal pocket depth -- a key indicator of gingivitis and periodontal disease progression. He also highlights the role of aged garlic extract in reducing inflammation and improving gum health, which in turn has significant implications for cardiovascular and cognitive health. The conversation also touches on various formulations of aged garlic extract available from Kyolic, the importance of integrative approaches to health and wellness, and updates on the latest trends in anti-aging medicine, including peptides and GLP-1 agonists.
Dr. Hoffman continues his conversation with clinical pharmacist, author, board-certified clinical nutritionist, and health expert Jim LaValle on the many health benefits of aged garlic extract.
Dr. Hoffman continues his conversation with Nathan Jones, CEO of Xlear, Inc.
Nathan Jones, CEO of Xlear, Inc., details the benefits of xylitol in dental and respiratory health products such as nasal sprays and chewing gums under the Spry brand. Nathan advocates for the FDA to allow anti-cavity claims for xylitol and other compounds despite the current monopoly of fluoride in such claims. They question the efficacy and potential downsides of fluoride, and explore alternative dental health interventions. The episode also covers xylitol's role in preventing tooth decay, respiratory health benefits during the COVID-19 pandemic, and ongoing legal challenges with the FTC. Discussions highlight the potential implications of oral health on systemic diseases like cardiovascular disease and Parkinson's, and emphasize the importance of nasal hygiene alongside dental care.
Connection can be the key to health, and those facing disconnection are at significantly higher risk of CVD, stroke, T2D, and other health issues. Guest Lora Peppard, PhD, DNP, PMHNP-BC, describes the importance of relationships and the 6 core beliefs that can help our patients and ourselves have improved health.Resources:Related PCNA CE course: https://pcna.net/course/the-extraordinary-impact-of-connection-on-mental-and-cardiovascular-health/Our Epidemic of Loneliness and Isolation: https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdfhttps://www.julianneholtlunstad.com/ https://bronnieware.com/regrets-of-the-dying/ https://www.zachmercurio.com/https://publichealth.jhu.edu/faculty/3038/christina-d-bethell Family Resilience Connection Index: https://nurtureconnection.org/child-flourishing-a-critical-indicator-for-erh/ American Psychiatric Nurses Association https://www.apna.org/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The FDA belatedly liberates women's hormone replacement; Beta-blockers now deemed passé for routine heart attack aftercare; After most breast cancer surgery, adjuvant radiation brings no survival benefits; Can you drink caffeinated coffee if you have atrial fibrillation? Ignore frequent falls without attention to balance and stability training at your peril; Is it reasonable to contemplate a knee replacement surgery at 88?
“Study” that's not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore dr's advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance. Give the gift of healthy chocolate! Go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide. Plus get free shipping on all orders over $30.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Zara Shirazi, a congenital cardiac surgery post-fellow at the National Institute of Cardiovascular Diseases, about advancing pediatric cardiac surgery in Pakistan using what she learned from her fellowship in Austria. Chapters 00:00 Intro 02:28 Vince TAVR Roundtables 03:05 Foreign Body, Case of the Month 03:49 JANS 1, Temporary MCS Guidelines 13:50 JANS 2, Parenting as a CT Surgeon 16:20 JANS 3, Utilization of Long Distance Donors 18:20 JANS 5, Multi-A Grafting in Redo CABG 20:58 Career Center 21:20 Video 1, Pulm & Tricuspid Endocarditis 22:35 Video 2, Valvular Heart Disease Guidelines 27:05 Video 3, Thoraflex Hybrid Graft Insertion 28:16 Zara Shirazi Interview 39:30 Upcoming Events 42:42 Closing They explored the advantages of working in a hospital in Pakistan compared to Austria, as well as the different techniques and operations, such as extracorporeal membrane oxygenation (ECMO). Dr. Shirazi also shared her experiences as a fellow in Austria and the valuable insights she gained from that experience. Additionally, she discussed her vision for the growth of her unit over the next five years and provided an overview of what a typical surgical week looks like in Pakistan. Joel also highlights recent JANS articles on the EACTS/STS/AATS guidelines on temporary mechanical circulatory support in adult cardiac surgery, the unique challenges and positive impacts on children raised by cardiothoracic surgeon mothers, evolving changes in center-level utilization of longer distance donors in heart transplantation, and multiarterial grafting in redo coronary artery bypass grafting. In addition, Joel explores pulmonary and tricuspid valve endocarditis, an interview with Drs. Borger and Marin-Cuartas on the guidelines for the management of valvular heart disease, and Thoraflex Hybrid graft insertion in a patient with Marfan syndrome. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned 1.) EACTS/STS/AATS Guidelines on Temporary Mechanical Circulatory Support in Adult Cardiac Surgery 2.) Parenting From the OR: The Unique Challenges and Positive Impacts on Children Raised by Cardiothoracic Surgeon Mothers 3.) Evolving Changes in Centre-Level Utilization of Longer Distance Donors in Heart Transplantation 4.) Multiarterial Grafting in Redo Coronary Artery Bypass Grafting: Type of Arterial Conduit and Patient Sex Determine Benefit CTSNet Content Mentioned 1.) Pulmonary and Tricuspid Valve Endocarditis: A Late Sequelae of Unrepaired Double Chambered Right Ventricle in an Adult 2.) Guidelines for the Management of Valvular Heart Disease: An Interview With Drs. Borger and Marin-Cuartas 3.) Thoraflex Hybrid Graft Insertion in a Patient With Marfan Syndrome Other Items Mentioned 1.) Adapting Global Innovations to Local Realities: Advancing Pediatric Cardiac Surgery in Pakistan—Lessons From Austria 2.) Roundtable: Perfecting TAVR Removal | Skills Sharpening With Vince Gaudiani 3.) Case of the Month: The Case of a Foreign Body 4.) Resident Video Competition 5.) The Cardiac Recovery Room 6.) Career Center 7.) CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein's role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers' advice to avoid fish oil.
Cardiovascular disease is the No. 1 killer of women nationwide, yet during midlife—the crucial time for prevention—many women fall out of regular medical care.Host Dr. Rachel Pope is joined by Dr. Lisa Larkin, an internal medicine and women's health expert and founder of Ms. Medicine. They discuss why women's cardiovascular risk spikes around menopause and what you can do about it now.The Midlife Risk SpikeDr. Larkin highlights a failure in the healthcare system: women aged 40 to 60 often receive the least medical care, right when prevention is most critical.The perimenopausal transition causes rapid and significant metabolic changes: Cholesterol rises and HDL protection declines. Development of insulin resistance. Increase in visceral fat (the "risky fat" around organs), which is a marker for cardiovascular disease.Standard risk tools often underestimate risk in women because they don't account for sex-specific factors like adverse pregnancy outcomes (preeclampsia, gestational diabetes). Women are also often allowed to run higher blood pressures, missing opportunities for early intervention.Management & The "Missed Boat" QuestionDr. Larkin stresses that Body Composition is more important than BMI, as most women gain risky visceral fat during this time. She recommends tracking body composition annually.For women in their mid-60s who ask if they've missed the boat on prevention or Hormone Therapy (HT): Assessment is Key: Dr. Larkin performs a highly individualized assessment, often utilizing a Coronary Calcium Score to check for established plaque. If Risk is Low: A patient with perfect health metrics and a Calcium Score of zero may still be a candidate for HT to treat symptoms and support bone health. If Risk is High: The priority is to aggressively fix every single risk factor (hypertension, elevated lipids) before considering hormones, as established plaque may carry more risk with estrogen.Dr. Larkin emphasizes that women must be their best advocates because the healthcare system is currently failing to provide the comprehensive care needed during this pivotal stage of life.
In this special episode, tax attorney Toby Mathis, Esq., shifts focus from financial health to physical health by welcoming William Donovan from the Pritikin Longevity Center to discuss America's number one killer: cardiovascular disease. William shares his personal story of reversing heart disease and eliminating the need for bypass surgery through lifestyle changes at Pritikin, explaining how their medically supervised program has helped thousands achieve remarkable health transformations. The conversation covers the alarming statistics showing that 50% of heart attack victims had normal cholesterol levels, the critical role of endothelial function and arterial plaque, and why traditional risk factors don't tell the whole story. William explains the Pritikin Program's three-pillar approach, combining a whole-food, plant-based diet low in calorie density, daily exercise routines including resistance training, and comprehensive lifestyle education. They discuss how participants typically see dramatic improvements in just two weeks - lowering cholesterol by 23%, reducing blood pressure, eliminating medications, and reversing diabetes. With insights on inflammation, the dangers of processed foods and added oils, and the importance of getting professional medical guidance, this episode provides actionable strategies for anyone concerned about heart health, especially business owners and investors who need to protect their most valuable asset: their health. Highlights/Topics: 0:00 Heart Disease Statistics and Personal Story 3:40 What Pritikin Does and Nathan Pritikin's Story 12:45 Opening the Center and 60 Minutes Validation 19:40 What Happens in One to Two Weeks at Pritikin 30:20 The Challenge of Getting Healthy in Modern Society 36:45 Inspiring Success Stories 39:20 GLP-1s vs Lifestyle Change 42:50 Three Big Myths About Heart Disease Share this with business owners you know Resources: Schedule Your FREE Consultation https://andersonadvisors.com/strategy-session/?utm_source=the-number-1-killer-in-america&utm_medium=podcast Tax and Asset Protection Events https://andersonadvisors.com/real-estate-asset-protection-workshop-training/?utm_source=the-number-1-killer-in-america&utm_medium=podcast Anderson Advisors https://andersonadvisors.com/ Toby Mathis YouTube https://www.youtube.com/@TobyMathis Toby Mathis TikTok https://www.tiktok.com/@tobymathisesq Clint Coons YouTube https://www.youtube.com/@ClintCoons
Cardiovascular-kidney-metabolic (CKM) syndrome is progressive, but can be halted or even reversed with effective management. Guests Chiai Ndumele, MD, PhD, and Joe Saseen, PharmD, BCPS, BCACP, describe the role of inflammation and how the biologic factors for diagnosis and treatment are nested within a patient's social context.2023 AHA Statement Cardiovascular-Kidney-Metabolic Health: https://www.ahajournals.org/doi/10.1161/cir.0000000000001184 Related Resources:PCNA CKM tools and resources: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/ AHA Cardiovascular Kidney Metabolic Health Presidential Advisory: https://professional.heart.org/en/science-news/cardiovascular-kidney-metabolic-health-a-presidential-advisoryAHA CKM Syndrome Implementation Guide: https://www.heart.org/en/professional/cardiovascular-kidney-metabolic-health/implementationPCNA CKM Resource list: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The bidiretional relationship between cardiac and renal systems means that any dysfunction can cause a cascade of health issues. Learn about team-based care strategies for nurses and other professionals to monitor and manage patients with these conditions from guests Andrew Bzowyckyj, PharmD, BCPS, CDCES, FAPhA, FADCES, and Serina Gbaba, DNP, MBA, FNP-BC.PCNA CKM tools and resources: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/ IPEC core competencies (Interprofessional Education Collaborative): https://www.ipecollaborative.org/ipec-core-competencies CVD in CKD: Pathophysiological Insights and Therapeutic Options: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050686Social Determinants of CVD:https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319811See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
* Add FAAN to Anita's creds after Oct. 18.Guests: Anita Rich, DNP, RN, CHFN, CDCES, FAAN, and Jane DeMeis.Related resources:PCNA CKM tools and resources: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/ 2025 ACC Expert Consensus Statement on Medical Weight Mgmt for Optimization of CV Health: https://www.jacc.org/doi/10.1016/j.jacc.2025.05.024 Adiponectin, Leptin and CV Disorders: (https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.314458Racial and Ethnic Disparities in Adult Obesity in the US: https://www.cdc.gov/pcd/issues/2019/18_0579.htmCardiometabolic Syndrome: A Global Health Issue: https://www.uspharmacist.com/article/cardiometabolic-syndrome-a-global-health-issueTaking Aim At Belly Fat: https://www.health.harvard.edu/newsletter_article/taking-aim-at-belly-fatGender Disparities in People Living with Obesity: https://pubmed.ncbi.nlm.nih.gov/34526743/ Systematic review and meta-analysis suggests obesity predicts onset of CKD: https://www.sciencedirect.com/science/article/pii/S0085253816307529AHA Weight-Loss Strategies for Prevention and Treatment of Hypertension: https://pubmed.ncbi.nlm.nih.gov/34538096/ Renal Fat Accumulation Assessed by MRI or CT and Metabolic Disorders: https://pmc.ncbi.nlm.nih.gov/articles/PMC12194363/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Daylight Savings Time changeover health myths busted; A doctor breaks her ankle and is billed $64,000 in uncovered expenses; Vitamin D shields life-prolonging telomeres, may help depression; The vaunted DASH Diet for hypertension faces off against low-carb alternative; The critical first 1000 days after conception—early life sugar avoidance yields major later life health dividends; Do you really need hot water to disinfect your hands?
Very few of us receive the nutrition that we need from our diet, making proper supplementation a vital part of our health. 68% of all Americans take supplements on a regular basis. In this episode, you'll find out:—Why Dr. Prather does NOT recommend multivitamins for most patients.—The safety of supplements and why you need lab tests before taking any supplement. (And the shocking number of deaths per year from PROPERLY prescribed pharmaceuticals.)—How the Structure/Function Health Care model practiced by Holistic Integration, by the FDA's own definition, truly does no harm.—Why Dr. Prather says America has "the best Disease Care in the entire world", but "one of the worst Health Care models in the entire world".—How "we could solve the health care crisis in America", improve patient outcomes, and reduce health care costs.—What the first line of patient care should be for pain management. (Hint: It's not opioids.)—The approach taken by Holistic Integration to determine exactly what supplementation a patient needs. And why Dr. Prather considers supplementation as "a very critical part" of his practice.—How 97% of all Cancer and Cardiovascular Disease cases are AVOIDABLE.—Why the nutritional quality of our food has deteriorated, making it "impossible to be healthy" from the food we eat.—Plus, find out how you can attend Dr. Prather's FREE Seminar on Heart Health this Wednesday, November 5th!http://www.TheVoiceOfHealthRadio.com
A new European Society of Cardiology clinical consensus statement deals with cardiovascular disease prevention and management in COVID-19, including cardiac long COVID. The report's lead author, Vassilios Vassiliou, MBBS, PhD, MA, discusses the guidance and key questions that remain about COVID-19 and the heart. Related Content: New Guidance on Cardiovascular Disease and COVID-19—From Infection to Long COVID to Vaccination
In today's episode, Dr. Scott Watier and Tommy Welling break down a groundbreaking 2025 systematic review examining intermittent fasting's impact on cardiovascular disease prevention, revealing how modified alternate day fasting and time-restricted eating outperform traditional calorie restriction for reducing blood pressure, blood sugar, and waist circumference. They explore the practical application of "fast cycling"—strategically combining daily 16-18 hour fasts with weekly 24-48 hour extended fasts—to maximize both adherence and metabolic benefits without feeling deprived. The hosts emphasize that these research findings reflect the power of fasting timing itself, independent of strict dietary rules, making this approach more sustainable than traditional dieting. They provide actionable guidance on establishing a consistent fasting baseline while incorporating periodic extended fasts to leverage the cardiometabolic advantages seen in the research. Whether you're looking to prevent cardiovascular disease, break through a weight loss plateau, or simply establish a maintainable fasting lifestyle, this episode delivers the evidence-based framework and practical strategies to make fasting work for your long-term health goals. Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting! Resources and Downloads: SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! SLEEP GUIDE DIRECT DOWNLOAD DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Partner Links: Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 25% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Our Community: Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://pmc.ncbi.nlm.nih.gov/articles/PMC12289860/pdf/13668_2025_Article_684.pdf
Nutritionist Leyla Muedin discusses the critical health impacts of visceral fat, which is the hidden fat around the organs, and its role in accelerating heart aging. Drawing from recent research conducted by the Medical Research Council and published in the European Heart Journal, she explains how visceral fat differs from subcutaneous fat and its association with inflammation, heart diseases, and premature aging. The episode also highlights the importance of exercise, diet, particularly low-carb intake, and hormone replacement therapy in managing visceral fat and reducing health risks. Leyla also shares practical dietary advice and underscores the significance of focusing on fat distribution over total body weight for better health outcomes.
Send us a textThe surprising link between oral bacteria and heart disease.Episode Summary: Dr. Pekka Karhunen explains the connection between oral bacteria, cholesterol, and cardiovascular disease, discussing how oxidized LDL cholesterol triggers inflammation in arteries, how bacteria from the mouth can infiltrate arterial plaques to form biofilms, and the implications for heart disease prevention through lifestyle changes like better oral hygiene.About the guest: Pekka Karhunen, MD, PhD is a medical doctor and forensic pathologist with decades of experience, specializing in cardiovascular diseases. He has created a unique biobank of coronary arteries from over 10,000 autopsies conducted in Finland. His research focuses on the role of bacteria in atherosclerosis, particularly through studying coronary artery plaques.Discussion Points:Cholesterol is essential for life, but oxidized low-density lipoprotein (LDL) cholesterol is seen as a foreign substance by the immune system, leading to chronic inflammation in coronary arteries.Macrophages ingest oxidized LDL, turning into dysfunctional foam cells that contribute to plaque buildup, known as atheromas, in arteries.Plaque rupture, potentially caused by increased pressure from cholesterol accumulation or hemorrhage within the plaque, can trigger heart attacks.Bacteria, especially from the mouth, can enter arterial plaques via bacteremia (e.g., from dental procedures) and form biofilms, evading immune detection.Biofilms in plaques, made of extracellular matrix like polysaccharides, protect bacteria and may contribute to plaque instability or calcification over time.Poor oral hygiene is linked to higher cardiovascular disease risk, as bacteria from dental infections can enter plaques, suggesting dental care as a preventive measure.Karhunen's research found oral bacteria, like Viridans streptococci, in coronary plaques, with unpublished data also detecting gut and skin bacteria, indicating diverse bacterial involvement.Related content:M&M 247: Cholesterol: Immune Benefits, Heart Health, Statins & Research Malpractice | Uffe Ravnskov*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts
Nutritionist Leyla Muedin, a registered dietician nutritionist, details the holistic health benefits of yoga for oral and gastrointestinal health. Based on recent research published in BMC Oral Health and the Journal of International Society of Preventive and Community Dentistry, she discusses how yoga can improve periodontal health by reducing stress and systemic inflammation. She also explores specific yoga poses and breathing techniques that support digestion and reduce stress-related gut issues like IBS. Throughout, Leyal emphasizes that yoga's benefits extend beyond flexibility, offering a holistic path to overall well-being. She encourages listeners to integrate yoga into their self-care routines for comprehensive health improvements.
My most recent coronary calcium score is 1200. What are your recommendations?My husband has been sweating like crazy during our walks. What may be causing this?How serious is RSV for seniors? What about healthy seniors?
The secrets of the world's oldest woman at 117: The microbiome and good genes as determinants of longevityWhat are your thoughts on plasmalogens?Our 24-year-old son has recently been diagnosed with Crohn's disease - help!
Perfect Aminos®️ vs. protein powders—which are better to stave off frailty? Cocoa extract supplements reduce age-related inflammation, and may curb chronic diseases; Being too skinny associated with higher risk of dying; One in eight Americans have tried GLP-1 drugs—but only half stick to them after one year, citing price, side effects; The many health benefits of saunas; Air pollution hikes cardiometabolic risk—as does harmful mouth bacteria; Is the flu shot truly a “vaccine” if it's only partially effective and has to be taken every year?
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Current treatments for heart disease fail to address root causes. Stents and bypass surgery only restore blood flow temporarily without tackling underlying endothelial dysfunction and inflammation driving heart disease Despite their ability to lower cholesterol, statins have limitations. While these drugs lower LDL cholesterol by 25% to 35%, they don't address oxidative damage or rebuild vessel health, leaving underlying inflammatory processes unchanged Excess linoleic acid (LA) from vegetable oils fuels heart disease. Modern diets contain 7.2% LA, as opposed to 2.8% a century ago. This creates mitochondrial dysfunction and dangerous oxidized LDL cholesterol formation Reducing LA intake shows measurable cardiovascular benefits. Limiting LA to under 5 grams daily reduces inflammatory markers like hsCRP by 15% and IL-6 by 10% within weeks Novel approaches like nanoparticle chelation show promise. Targeted delivery systems can address calcified plaques directly, offering more precise treatment than traditional intravenous methods at lower costs