Podcasts about cvd

HEALTH NEWS   Study links low vitamin C levels in the blood plasma to reduced brain connectivity Study: Tart Cherry Supplementation Alters Muscle Protein Profile After Exercise Socioeconomic factors may leave more lasting imprint on children's brains than IQ or parenting style Fasting-mimicking diet reduces gum disease inflammation Low blood pressure shows strongest link to Alzheimer's disease   Study links low vitamin C levels in the blood plasma to reduced brain connectivity Hirosaki University (Japan), June 10 2026 (News-Medical) Previous research has uncovered associations between diets higher in vitamin C and lower risk of cognitive impairment in older adults. However, few studies have looked directly at vitamin C levels in blood plasma and potential associations with brain structure and connectivity within brain networks. To help fill that gap, Nagaya and colleagues analyzed magnetic resonance imaging (MRI) scans and plasma vitamin C levels of 2,044 adults over the age of 64. Specifically, they measured the volume of each participant's gray and white brain matter (accounting for individual differences in total brain volume between participants). They also evaluated connectivity within the default mode network, which is associated with several cognitive functions, such as attention and autobiographical memory. After statistically accounting for other factors the researchers found that participants with lower plasma vitamin C levels tended to have lower gray matter volume, as well as lower connectivity within the default mode network. These findings suggest the possibility that optimal levels of vitamin C in blood plasma could potentially support cognitive function and counteract cognitive decline. However, the findings do not confirm any such cause-effect relationship between vitamin C levels and brain health.   Study: Tart Cherry Supplementation Alters Muscle Protein Profile After Exercise University of Exeter (UK), June 11 2026 (Natural News) Researchers recruited 34 healthy, recreationally active young men and assigned them to receive either a placebo, a low-dose tart cherry concentrate, or a high-dose tart cherry supplement, according to the study report. Participants consumed their assigned supplement for seven days before completing a muscle-damaging workout and continued supplementation for three days afterward, for a total intervention of 10 days. The study found that tart cherry supplementation significantly altered the muscle's protein profile following exercise-induced damage. Changes were observed in proteins involved in muscle structure, contraction, cellular repair processes, and immune-cell activity within muscle tissue. These findings suggest that tart cherry polyphenols may influence the way muscles respond to and recover from the stress of exercise. Researchers also detected significant increases in hippuric acid, a compound produced when gut microbes break down polyphenols from tart cherries and other plant foods. Participants with higher levels of hippuric acid tended to maintain better muscle function following exercise-induced damage.   Socioeconomic factors may leave more lasting imprint on children's brains than IQ or parenting style Washington University in St. Louis, June 11 2026 (Medical Xpress) After analyzing hundreds of biological, psychological, social and environmental factors related to children's development, researchers at Washington University School of Medicine in St. Louis found that a family's financial situation and the resources and opportunities in a child's neighborhood had the strongest connection to brain development. Socioeconomic factors accounted for about 16% of the variability in measures of children's brain function—far more than IQ, parenting style and health history.  As part of the study, the researchers analyzed brain scans from nearly 12,000 children ages 9 to 10 to see how a child's environment, health and regular activities are related to brain development. Of the hundreds of factors examined, the team found that the socioeconomic status of a child's family had the strongest relationship with that child's brain structure and function. Further, the parts of the brain that reflect socioeconomic factors were the same areas most sensitive to sleep and stress, suggesting that socioeconomic disadvantage affects the brain indirectly through disrupted sleep and chronic stress. Of the top 40 variables linked to brain function, 37 were socioeconomic, and of the top 40 tied to structure, 35 were socioeconomic. These included the social and economic resources in the child's neighborhood, akin to the overall wealth of an area. Strong influences included family income, homeownership, poverty rates and access to transportation. The remaining top variables were related to sleep, screen time and stress.   Fasting-mimicking diet reduces gum disease inflammation Kings College London, June 11 2026 (Eurekalert) People who follow a short-term low-calorie diet may have reduced markers of inflammation associated with gum disease. A new study by King's College London highlights how lifestyle modifications could be important alongside plaque control in managing gum disease. The research included 28 patients from across hospitals in Spain, split into two groups – those who followed a five-day restrictive diet, versus a control group who continued their usual diet. Patients who fasted ate 1,100 calories for two days, then 750 calories for three days. The sixth day gently introduced more calories with soft foods – then their diets returned to normal by the seventh day. This was repeated three times in six months, with patients reporting the diet easy to stick to. After six months, samples were analysed from the patients' blood and gingival crevicular fluid – liquid that comes from the small space between your tooth and gum, which helps gums stay healthy and fight germs. Those who fasted had reduced markers of inflammation in samples from blood and gum tissue compared to those whose diets stayed the same, including lower levels of C-reactive protein, a general indicator of inflammation around the body. The fasting group also had reduced molecules linked to inflammation specifically in the gums, compared to controls.   Low blood pressure shows strongest link to Alzheimer's disease Michigan Technological University, Jun 10 2026 (News-Medical) Numerous types of cardiovascular disease and CVD risk factors were linked to a higher risk of Alzheimer's disease, with low blood pressure showing the strongest connection, according to a new analysis published today in the Journal of the American Heart Association What are the key findings of the analysis? Adults with hypotension (low blood pressure) were about three times more likely to develop Alzheimer's and nearly twice as likely in the All of Us study when compared to individuals who did not have low blood pressure. Across both datasets, adults with high blood pressure (hypertension) were 1.6 times more likely to have Alzheimer's disease, compared to people without hypertension. Participants who had a previous stroke had a 1.5 times higher risk for Alzheimer's disease in the UK Biobank and 1.85 times in All of Us. Those with irregular heartbeat (or atrial fibrillation, also called AFib) were about 1.5 times more likely to have Alzheimer's disease compared to those without AFib.    

In der neuen Folge von Breach FM melde ich mich aus Helsinki, wo es derzeit nicht dunkel wird, Max Imbiel darf glücklicherweise wieder im Homeoffice sein. The Record from Recorded Future News berichtet, dass Shyam Sankar, CTO von Palantir und seit über 20 Jahren im Unternehmen, als führender Kandidat für die seit Januar 2025 vakante CISA-Direktorenstelle gilt. Das White House dementierte mit "at this time this is not accurate" – was kein Dementi ist. Relevant wird die Personalie vor allem im zeitlichen Zusammenhang mit der neuen KI-Executive-Order, die die CISA erstmals mit durchsetzungsfähigen Binding Operational Directives ausstattet. Von Cyber-Koordinator zur KI-Governance-Behörde – wir haben da kein gutes Bauchgefühl.Das Kernthema bringt Max: der Nightmare-Eclipse-Eklat bei Microsoft. Der Researcher hat zwischen April und Mitte Mai sechs Windows-Zero-Days veröffentlicht – BlueHammer, RedSun, UnDefend, YellowKey, GreenPlasma und MiniPlasma – alle ohne vorherige Koordination. Microsoft reagierte mit juristischen Drohungen, ruderte nach Community-Aufschrei zurück. Drei Exploits wurden aktiv ausgenutzt und ins KEV aufgenommen. Adam Shostack, Mitbegründer von Microsofts eigenem Threat-Modeling-Ansatz, kritisierte den Umgang offen. Der Kernvorwurf: Microsoft hält sich selbst nicht an seinen CVD-Prozess – Researcher spielen Bugs jetzt lieber untereinander weiter. Der Schaden trifft alle Nutzer.Dann der Meta-Instagram-"Hack": Angreifer nutzten den Meta-KI-Support-Chatbot, um einfach eine neue E-Mail-Adresse am Zielkonto zu hinterlegen – der Bot schickte den Reset-Code dorthin, ohne zu verifizieren. Mindestens 20.225 Konten betroffen, darunter der Obama-White-House-Account. Angriffsfenster: sieben Wochen. Moral: Schreibrechte gehören nicht in Chatbots im Authentifizierungsflow – und 2FA aktivieren.Shyam Sankar / CISA-Nominierung (The Record) https://therecord.media/trump-considers-palantir-exec-to-lead-cisaNightmare Eclipse: alle sechs Zero-Days im Überblick https://cipherssecurity.com/nightmare-eclipse-microsoft-windows-zero-day/Microsoft Statement zu CVD und Nightmare Eclipse https://cybersecuritynews.com/microsoft-clarifies-nightmare-eclipse-controversy/Meta Instagram Chatbot-Hack (404 Media) https://www.404media.co/hackers-simply-asked-meta-ai-to-give-them-access-to-high-profile-instagram-accounts-it-worked/Meta bestätigt 20.225 betroffene Konten https://this.weekinsecurity.com/meta-confirms-thousands-of-instagram-accounts-were-hacked-by-abusing-its-ai-chatbot/

Menopause Management In Women with Cardiovascular Disease   Guest: Chrisandra Shufelt, M.D. Host: Marysia Tweet, M.D., M.S.   Listeners of this episode of “Interviews with the Experts” will gain a practical, evidence-based framework for managing menopausal symptoms in women with cardiovascular disease or elevated CVD risk. Through discussion of patient selection, menopause-specific cardiovascular risk factors, and the evolving data on hormone therapy. Listeners will leave better equipped to individualize care and counsel patients with confidence.   Topics Discussed: Treatment for menopause symptoms in women with risk factors for CVD  Appropriate candidates for hormone therapy Which cardiovascular risk factors are attributable to ovarian aging (menopause) versus chronological aging? What does the current evidence show regarding claims that menopausal hormone therapy prevents cardiovascular disease? How might the FDA's removal of the black box warning from menopausal hormone therapy labeling affect clinician prescribing practices and patient decision-making?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded on: 15-January-2026

In this episode, Dr Angus Sinclair speaks with Dr Jonathan Malo about dyslipidaemias. They discuss the different types of dyslipidaemias, the treatments (including some new ones) and the types of cases that should be referred. Dr Jonathan Malo is a consultant chemical pathologist at the Department of Clinical Biochemistry in NHS Lothian. And is the clinical lead for the Lipid Clinic at the Royal Infirmary of Edinburgh. He currently chairs a Scottish network of lipid clinic specialists, and is involved in a Scottish government group tasked with improving CVD prevention. Dr Angus Sinclair is an Internal Medical Trainee in the East of Scotland. He graduated from the University of Edinburgh in 2018 and since then has worked across Scotland and as a medical registrar in a rural district general hospital in New Zealand. He has been actively involved in undergraduate and postgraduate teaching, as well as in clinical governance and resident doctor leadership. Recording date: 20 March 2026 --Links-- Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials, The Lancet, 2026; 407, 689-703. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials, The Lancet, 2022; 400, 832-845. N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects, NEJM, 2020;383:2182-2184. DOI: 10.1056/NEJMc2031173. Statin treatment and muscle symptoms: series of randomised, placebo-controlled n-of-1 trials. BMJ, 2021;372:n135. https://doi.org/10.1136/bmj.n135 SIGN 149: Risk estimation and the prevention of cardiovascular disease (2017) - https://www.sign.ac.uk/assets/qrg149.pdf NICE Guideline 238: Cardiovascular disease: risk assessment and reduction, including lipid modification (2023) - https://www.nice.org.uk/guidance/ng238/resources/cardiovascular-disease-risk-assessment-and-reduction-including-lipid-modification-pdf-66143902851781) AHA guideline - https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 ASSIGN/QRISK score calculators - https://www.heartuk.org.uk/educational-content/risk-calculators -- Follow us -- https://www.instagram.com/rcpedintrainees -- Upcoming RCPE events -- https://www.rcpe.ac.uk/events -- Become an RCPE Member -- https://www.rcpe.ac.uk/membership/join-college Feedback: cme@rcpe.ac.uk This podcast is from the Trainees & Members' Committee (T&MC) of the Royal College of Physicians of Edinburgh (RCPE).

Pregnancy, Labor and Delivery, and Postpartum Care in Women with Cardiovascular Disease   Guest: Carl Rose, M.D. Guest: Katie Young, M.D. Guest: Katherine Arendt, M.D. Host: Marysia Tweet, M.D., M.S.   Where patients deliver babies matters, particularly for women with cardiac disease. In this episode, Dr. Marysia Tweet interviews three experts on CVD, OB, and anesthesia. High-risk centers provide 24/7 in-house obstetric anesthesia and multidisciplinary resources that support anticipatory planning and rapid response to obstetric, cardiovascular, and anesthesia emergencies during labor and delivery. Whenever possible, cardiac obstetric patients should be managed by a multidisciplinary Pregnancy Heart Team from preconception to delivery to optimize planning and outcomes.    Topics Discussed: Role of an obstetric anesthesiologist on a labor and delivery unit Coordination of cardiology, OB anesthesia, MFM, and nursing care during labor and delivery Cardiac indications for assisted vaginal delivery and cesarean delivery Telemetry and ICU level monitoring postpartum   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded on: 19-February-2026

In this sponsored episode from Novartis Pharmaceuticals Corporation, a leading preventive cardiologist walks through the 2026 cholesterol guideline update and what it means in practice. Seth J. Baum, a Columbia-trained preventive cardiologist, founder of Flourish Research, chairman of the Family Heart Foundation, and past president of the American Society of Preventive Cardiology, breaks down the major changes in the March 2026 ACC and AHA guideline release. You will hear why LDL targets are explicit again after nearly a decade, why universal lipoprotein A screening is now recommended, why a coronary calcium score above 300 places a patient in the highest-risk treatment tier, and why apolipoprotein B measurement can refine risk assessment when LDL is at goal. Baum also covers the alternatives available when a patient cannot tolerate a statin, including ezetimibe, PCSK9 inhibitors, inclisiran, and bempedoic acid, along with practical framing for the statin-hesitant patient. You will also hear his approach to discussing cholesterol with patients, from the science of lipoprotein physiology to the case for earlier and more aggressive lipid-lowering treatment. Dr. Baum was not compensated for his participation in today's episode. The opinions expressed are his alone and do not represent the opinions of Novartis Pharmaceuticals Corporation. At Novartis, our mission is to ensure no heart is lost too soon. We envision a world where preventable CV deaths are no longer part of our lives. We're proud of the positive impact we've made over the past 40 years and remain dedicated to tackling the most challenging problems in CVD. Through cutting-edge science and technology, we are focusing on areas of high unmet need, including scaling our xRNA platform across multiple risk factors and pioneering breakthroughs for genetically driven CVD risk factors and common heart conditions, including atrial fibrillation. We also work with patients, healthcare professionals, and organizations around the world to improve CV care beyond medicine alone. Together, we can help people with CVD enjoy longer, healthier lives and more time with their loved ones. Learn more here: https://Novartis.us/cardiovascular-disease VISIT SPONSOR → https://Novartis.us/cardiovascular-disease SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

In this episode, Prof Clare Collins talks with Ilyse Jones about the role of nuts in heart health, highlighting recent research, nutritional benefits, and practical tips for incorporating nuts into a heart-healthy diet. They discuss how nuts can reduce cardiovascular risk and easy ways to boost your fiber intake with delicious, budget-friendly meal options.Key topicsNuts and heart health researchNutritional benefits of nutsDietary fiber and cardiovascular healthThis episode was supported by Nuts for Life: https://www.nutsforlife.com.au/Check the Heart Foundation information about Heart Healthy Eating Patterns https://www.heartfoundation.org.au/healthy-living/healthy-eating/heart-healthy-eating-patternAustralian Heart Foundation Nutrients Fact Sheet https://www.heartfoundation.org.au/for-professionals/clinical-information/nutrients-and-dietary-fiberNuts for Life: Everything you need to know about nuts https://www.nutsforlife.com.au/resource/fact-sheet-everything-you-need-to-know-about-nuts/Nuts for life: What does a 30 gram serve of nuts look like? https://www.nutsforlife.com.au/resource/what-does-a-30g-serve-of-nuts-look-like/To access the Healthy Eating Quiz: Click on the top right hand 'green button' called 'How healthy is my diet' https://nomoneynotime.com.au/Want a more Personalised Food, Nutrient Assessment Report? Use our Australian Eating Survey - For a 50% discount enter the 'DietCheck' code at the checkout! Purchase here https://australianeatingsurvey.com.au/Here's the link to the No Money No Time closed Facebook group (be sure to take the Healthy Eating Quiz first) https://www.facebook.com/groups/386824626838448Our No Money No Time email: nmnt@newcastle.edu.au and our Nutrition Science Bites email: nutritionsciencebites@newcastle.edu.au Are you in a position to make donation to support our No Money No Time website? Donate hereKeywords: #hearthealth, #nuts, #dietaryfiber, #cardiovasculardisease, #CVD, #nutrition, #HeartFoundation, #healthyfats, #AustralianNuts, #fiberintake, #heartweek Hosted on Acast. See acast.com/privacy for more information.

Metabolic dysfunction-associated steatotic liver disease (MASLD) plays a pivotal role in cardiometabolic health, driven by its bidrectional relationship with cardiovascular disease (CVD) and its impact on long-term morbidity and mortality. This interdisciplinary vodcast explores the shared pathophysiologic pathways connecting MASLD and CVD and underscores the importance of comprehensive risk evaluation. A panel of experts discusses practical, evidence-based strategies for managing MASLD, including lifestyle interventions and the evolving landscape of pharmacologic therapies. The program highlights emerging cardiometabolic agents, including GLP 1-based therapies, ande their potential to slow disease progression and reduce cardiovascular risk in affected patients. 

CardioNerds (Drs. Natalie Marrero, Shivani Reddy, and Rebecca S. Steinberg), discuss the role of SGLT2i in cancer therapy-related cardiac dysfunction (CTRCD) with Dr. Manu Murali Mysore. This episode was produced as part of the CardioNerds Academy curriculum by House Taussig under the guidance of House Chief, Dr. Natalie Marrero, and Academy Program Director, Dr. Gurleen Kaur. A matching review article will be published in US Cardiology Review, the official journal of CardioNerds. Audio editing for this episode was performed by CardioNerds Intern, Dr. Julia Marques Fernandes. Summary: Cancer therapy-related cardiac dysfunction (CTRCD) spans a spectrum from subclinical biomarker elevation to overt heart failure, with risk amplified by preexisting cardiovascular disease, diabetes, hypertension, obesity, and exposure to therapies, such as anthracyclines, HER2-targeted therapies, or radiation. This episode explores the emerging and promising role of SGLT2 inhibitors as a cardioprotective adjunct in cardio-oncology — examining mechanisms, clinical evidence, ongoing trials, and critical knowledge gaps — while affirming that guideline-directed medical therapy remains the cornerstone of prevention and treatment. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Cardio-Oncology PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls CTRCD is a spectrum — catch it early. CTRCD ranges from subclinical injury detected by imaging and biomarkers to overt heart failure. Early identification in high-risk patients (preexisting CVD, diabetes, HTN, obesity, anthracycline/HER2/radiation exposure) is essential, and early initiation of guideline-directed medical therapy — including ACE inhibitors/ARBs/ARNIs, mineralocorticoid receptor antagonists, and beta-blockers — remains the backbone of prevention and treatment to preserve LVEF and allow safe continuation of cancer therapy. SGLT2 inhibitors are a promising new pillar of cardioprotection in cardio-oncology. They act through a unique combination of mechanisms: renal effects, metabolic reprogramming of the myocardium, anti-inflammatory and antioxidant pathways, and vascular fibrosis modulation — making them a compelling complement to standard therapies rather than a replacement. Early clinical data is encouraging but not yet definitive. The 2024 EMPACARD-PILOT trial demonstrated preserved LVEF and reduced CTRCD in higher-risk patients with diabetes or kidney disease. Ongoing trials — EMPACT and PROTECT — are actively exploring SGLT2 inhibitors for primary prevention during anthracycline and HER2-targeted therapy. SGLT2 inhibitors are NOT yet indicated for ICI-related myocarditis. Immune checkpoint inhibitor (ICI)-related myocarditis is mechanistically immune-driven. While SGLT2 inhibitors have theoretically anti-inflammatory benefits, there is currently no clinical evidence to support their use in this specific setting. The use of SGLT2 inhibitors should be guided by patient risk, existing indications, and ongoing research. Large prospective trials, clarity on timing and patient selection, long-term safety data, and deeper mechanistic understanding in humans remain the most urgent gaps in the field before broader adoption can be recommended. References Theofilis P, Vlachakis PK, Oikonomou E, et al. Cancer therapy-related cardiac dysfunction: A review of current trends in epidemiology, diagnosis, and treatment. Biomedicines. 2024;12(12):2914. doi:10.3390/biomedicines12122914. https://pubmed.ncbi.nlm.nih.gov/39767820/ Lyon AR, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-1960. doi:10.1002/ejhf.1920. https://pmc.ncbi.nlm.nih.gov/articles/PMC8019326/ Li X, Li Y, Zhang T, et al. Role of cardioprotective agents on chemotherapy-induced heart failure: A systematic review and network meta-analysis of randomized controlled trials. Pharmacol Res. 2020;151(104577):104577. doi:10.1016/j.phrs.2019.104577. https://pubmed.ncbi.nlm.nih.gov/31790821/ Lee YH, Lim S, Davies MJ. Cardiometabolic and renal benefits of sodium-glucose cotransporter 2 inhibitors. Nat Rev Endocrinol. 2025;21(12):783-798. doi:10.1038/s41574-025-01170-4. https://pubmed.ncbi.nlm.nih.gov/40935880/ Dabour MS, George MY, Daniel MR, Blaes AH, Zordoky BN. The cardioprotective and anticancer effects of SGLT2 inhibitors: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 2024;6(2):159-182. doi:10.1016/j.jaccao.2024.01.007. https://pubmed.ncbi.nlm.nih.gov/38774006/ Armillotta M, Angeli F, Paolisso P, et al. Cardiovascular therapeutic targets of sodium-glucose co-transporter 2 (SGLT2) inhibitors beyond heart failure. Pharmacol Ther. 2025;270(108861):108861. doi:10.1016/j.pharmthera.2025.10886. https://pubmed.ncbi.nlm.nih.gov/40245989/ Góes-Santos BR, Castro PC, Girardi ACC, Antunes-Correa LM, Davel AP. Vascular effects of SGLT2 inhibitors: evidence and mechanisms. Am J Physiol Cell Physiol. 2025;329(4):C1150-C1160. doi:10.1152/ajpcell.00569.2025. https://pubmed.ncbi.nlm.nih.gov/40908107/ Daniele AJ, Gregorietti V, Costa D, López-Fernández T. Use of EMPAgliflozin in the prevention of CARDiotoxicity: the EMPACARD – PILOT trial. CardioOncology. 2024;10(1):58. doi:10.1186/s40959-024-00260-y. https://pubmed.ncbi.nlm.nih.gov/39237985/ Clinicaltrials.gov. Clinicaltrials.gov. Accessed April 16, 2026. https://clinicaltrials.gov/study/NCT05271162 Greco A, Quagliariello V, Rizzo G, et al. SGLT2i Dapagliflozin in primary prevention of chemotherapy induced cardiotoxicity in breast cancer patients treated with neo-adjuvant anthracycline-based chemotherapy +/- trastuzumab: rationale and design of the multicenter PROTECT trial. CardioOncology. 2025;11(1):79. doi:10.1186/s40959-025-00368-9. https://pmc.ncbi.nlm.nih.gov/articles/PMC12400668/ Key Guideline Reference: Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international cardio-oncology society (IC-OS). Eur Heart J Cardiovasc Imaging. 2022;23(10):e333-e465. doi:10.1093/ehjci/jeac106. https://pubmed.ncbi.nlm.nih.gov/36017575/ Be sure to check out the corresponding review article on the cardioprotective role of SGLT2 inhibitors in CTRCD that will be published in US Cardiology Review, the official journal of CardioNerds. Additionally, please reference CardioNerds Cardio-Oncology Episodes 261 and 274 for related content.

Your doctor says your magnesium is normal. But that test measures less than 1% of your body's total magnesium. Nearly half of US adults are deficient in the mineral required for 600+ enzymatic reactions, every ATP molecule, insulin signaling, blood pressure, heart rhythm, and sleep.CHAPTERS:00:00 — Introduction00:55 — Part 1: The Hidden Deficiency02:10 — Soil depletion02:55 — 80% lost in food processing03:25 — Serum test only measures 1%04:30 — Part 2: The Insulin Connection04:55 — Mg required for GLUT4 and insulin signaling06:45 — 22% lower diabetes risk with higher Mg07:45 — Part 3: Heart, Blood Pressure, Inflammation08:05 — 36% lower CVD risk08:40 — Mg lowers BP 2.8 mmHg10:10 — Part 4: Sleep and the Nervous System10:30 — Mg activates GABA, blocks NMDA11:30 — RCT: improved sleep, deep sleep, HRV12:00 — Part 5: What to Do12:15 — Get RBC magnesium test13:00 — Best forms: glycinate, threonate, citrateREFERENCES:Global Deficiency 2.4B (Int J Vitam Nutr Res, 2025): pubmed/41504160Soil Depletion 80% Loss (Heliyon, 2020): PMC7649274Mg + GLUT4 Insulin Signaling (Frontiers Endocrinology, 2022): fendo.2022.786516Mg + T2D Risk 536K Participants: pubmed/21868780Mg + CVD Review (Nutrients, 2024): PMC11013654Mg Lowers BP — 38 RCTs (Hypertension, 2025): pubmed/40145305Mg + Sleep Quality (2024): pubmed/38455453HOST: Dr. Robert Lufkin MD | robertlufkinmd.comNew episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Apologies for the delayed publication and sound quality this month - hopefully this is still useful. Dr Dave teaches Dr Jo about · UTI in children, Gynaecomastia, Fournier gangrene, Zoledronic acid in the elderly, GLP-1 Ras – skin and eyes, Coffee after AF ablation, Paracetamol in pregnancy, Morphine and breathlessnessand our equity focus this month is on , CVD risk assessments, and Cancers and excess body weightWe talk about the MCNZ statement on use of AI, GP2GP, Meningococcal disease and The Pitt.

Menorrhagia Management in Women with Cardiovascular Disease   Guest: Shannon Laughlin-Tommaso, M.D. Host: Marysia Tweet, M.D., M.S.   Heavy menstrual bleeding is a condition that occurs before menopause and can be caused by both hormonal and structural conditions, like fibroids or adenomyosis. There are many medical and procedural options for treating bleeding which are safe in women with CVD. Although hysterectomy is a definitive option for HMB, it can increase risks of CVD in young women.   Topics Discussed: What are the causes of heavy menstrual bleeding? what are the options for treating heavy menstrual bleeding in patients on or off anticoagulation?  Is heavy menstrual bleeding a risk factor for CVD?    Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded 06-January-2026

In this episode of Walk Don't Run to the Doctor, Miles Hassell MD breaks down one of the most debated topics in nutrition: saturated fat. For decades, saturated fat has been blamed as a major cause of heart disease—but what if the evidence isn't as clear as we've been told? This episode explores the history behind dietary guidelines, the evolving food pyramid, and why current research is challenging long-held beliefs about fat, cholesterol, and overall health. You'll learn how whole foods, processed foods, and the broader "food matrix" play a much bigger role than simply avoiding saturated fat. If you've ever been confused about what to eat—or felt like nutrition advice keeps changing—this conversation will help you think more critically about the science behind it all. Key Takeaways Saturated fat has been widely criticized since the 1950s, but much of the original evidence is weak or inconclusive Recent research shows little to no clear link between saturated fat and heart disease or mortality Not all saturated fats—or foods containing them—are the same (whole foods vs. processed foods matter) Dairy, red meat, and other whole-food sources of saturated fat may be neutral or even beneficial Ultra-processed foods, refined sugars, and white flour have far stronger evidence of harm Overall diet quality, lifestyle, and metabolic health matter far more than focusing on a single nutrient     [1] Talukdar, J. R., et al. (2023). Saturated fat, the estimated absolute risk and certainty of risk for mortality and major cancer and cardiometabolic outcomes: an overview of systematic reviews. Systematic reviews, 12(1), 179. https://doi.org/10.1186/s13643-023-02312-3 [2] Valk, R., et al. (2022). Saturated fat: villain and bogeyman in the development of cardiovascular disease? European journal of preventive cardiology, 29(18), 2312–2321. https://doi.org/10.1093/eurjpc/zwac194 [3] Krauss, R. M., et al. (2020). Public health guidelines should recommend reducing saturated fat consumption as much as possible: NO. The American journal of clinical nutrition, 112(1), 19–24. https://doi.org/10.1093/ajcn/nqaa111 [4] Dunne, S., et al. (2024). The effects of saturated fat intake from dairy on CVD markers: the role of food matrices. The Proceedings of the Nutrition Society, 83(4), 236–244. https://doi.org/10.1017/S0029665124000132 [5] Du, Y., et al. (2026). High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study. Neurology, 106(2), e214343. https://doi.org/10.1212/WNL.0000000000214343 [6] Yuan, M., et al. (2022). Saturated fat from dairy sources is associated with lower cardiometabolic risk in the Framingham Offspring Study. The American journal of clinical nutrition, 116(6), 1682–1692. https://doi.org/10.1093/ajcn/nqac224 [7] Dehghan, M., et al., … Prospective Urban Rural Epidemiology (PURE) study investigators (2017). Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet (London, England), 390(10107), 2050–2062. https://doi.org/10.1016/S0140-6736(17)32252-3 [8] Astrup, A., et al. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. https://doi.org/10.1016/j.jacc.2020.05.077

In this episode of the ESVS Podcast, supported by Servier, we explore the importance of therapy adherence in chronic venous disease (CVD). The episode opens with short patient testimonies, highlighting real-world reasons for non-adherence.To explore this further, we are joined by Professor Denisa Celovska and Professor Atul Pathak. Professor Celovska is an Associate Professor of Angiology and Internal Medicine at the University Hospital and Comenius University in Bratislava, Slovakia. She is currently the President of the Slovak Angiology Society. Professor Pathak is the Head of the National Institute of Cardiology, Cardiac Surgery and Interventional Cardiology in Luxembourg.In this episode, they share their clinical perspective on why patients frequently disengage from treatment, the most common barriers to adherence in daily practice, and practical strategies to improve long-term treatment persistence.The episode also includes insights from a community pharmacist, offering a complementary view on what happens between prescription and real-life use, particularly regarding venoactive drugs. We conclude by emphasising that effective CVD management extends beyond prescribing treatment. Patient education, shared decision-making, follow-up, and human connection are essential to improve adherence and long-term outcomes in CVD.References:Kim H, Cho S, Lee K, Lee SH, Joh JH. A nationwide study of compliance of venoactive drugs in chronic venous disease patients. Ann Surg Treat Res. 2023 May;104(5):288-295. doi: 10.4174/astr.2023.104.5.288. Epub 2023 Apr 28. PMID: 37179697; PMCID: PMC10172027.Burnier M. The role of adherence in patients with chronic diseases. Eur J Intern Med. 2024 Jan;119:1-5. doi: 10.1016/j.ejim.2023.07.008. Epub 2023 Jul 20. PMID: 37479633.Mezalek ZT, Feodor T, Chernukha L, Chen Z, Rueda A, Sánchez IE, Ochoa AJG, Chirol J, Blanc-Guillemaud V, Lohier-Durel C, Ulloa JH. VEIN STEP: A Prospective, Observational, International Study to Assess Effectiveness of Conservative Treatments in Chronic Venous Disease. Adv Ther. 2023 Nov;40(11):5016-5036. doi: 10.1007/s12325-023-02643-6. Epub 2023 Sep 20. Erratum in: Adv Ther. 2024 Jan;41(1):464-465. doi: 10.1007/s12325-023-02722-8. Erratum in: Adv Ther. 2024 Jun;41(6):2540-2541. doi: 10.1007/s12325-024-02857-2. PMID: 37728696; PMCID: PMC10567827.Bogachev, V., Arribas, J.M.J., Baila, S. et al. Management and evaluation of treatment adherence and effectiveness in chronic venous disorders: results of the international study VEIN Act Program. Drugs Ther Perspect 35, 396–404 (2019). https://doi.org/10.1007/s40267-019-00637-5Golna C, Poimenidou C, Giannoukari EE, Saridi M, Liberopoulos E, Souliotis K. Assessing a pharmacist-enabled intervention to improve adherence to medication for hypertension, dyslipidemia, and chronic venous circulation disorders in Greece. Patient Prefer Adherence. 2023;17:3341–3352. doi:10.2147/PPA.S4208116. Branisteanu DE, Munteanu AE, Dolofan BM, Popescu EG, Vittos O. Adherence to pharmacological treatment in chronic venous disease: results of a real-world, prospective, observational cohort study. Life (Basel). 2025;15(3):377. doi:10.3390/life15030377.7. Ulloa JH, Guerra D, Cadavid LG, Fajardo D, Villarreal R, Bayona G, Hoyos AS, Garcia G. Nonoperative approach for symptomatic patients with chronic venous disease: results from the VEIN Act program. Phlebolymphology. 2018;25(2):123Servier is a financial sponsor of this podcast, which has been independently developed by the presenters and does not constitute medical advice from Servier. Always consult the Instructions for Use (IFU) prior to using any medical device.

This episode examines whether unprocessed red meat has a causal role in (1) type 2 diabetes risk and intermediate measures of glucose intolerance (insulin resistance, beta cell dysfunction, glycemic markers) and (2) cardiovascular disease (CVD) risk. While there is commonly observed risk signal from observational cohorts, there exist short-term randomized controlled trials (RCTs) that show largely null effects on glucose homeostasis. This had led to differing opinions and interpretations of the evidence base. Some feel that in the context of an otherwise healthy diet, there isn't much to suggest concern about consuming unprocessed red meat. While others are of the view that there does exist a risk and that limiting or even avoiding consumption is prudent. The crucial concept of replacement effects is discussed. Increasing red meat intake always means decreasing something else or increasing total energy intake. Therefore, interpreting evidence requires specifying the comparator food(s), the background dietary pattern, the dose, the cut (lean vs fatty), and how the meat is prepared. To discuss their interpretations of this contentious evidence base, Dr. Mario Kratz and Dr. Gil Carvalho join the podcast to go through the studies most directly related to these questions. Timestamps [06:20] Red meat's impact is debated [10:54] Mechanisms linking meat to diabetes [15:31] Cohort evidence on diabetes risk [24:43] Differences between cohorts and threshold effects [33:13] RCT evidence and substitution trials [45:49] Why comparator foods matter [50:43] RCT examples and mixed results [01:00:30] Is there cardiovascular risk beyond saturated fat? [01:08:10] Epidemiology patterns and dose thresholds [01:11:36] Personal recommendations and risk tolerance [01:16:19] Key ideas Related Resources Go to episode page (study links, guest bios, additional resources) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Mario's YouTube channel: Nourished By Science Gil's YouTube channel: Nutrition Made Simple!

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer's, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior.  Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Alex Chaitoff (@alexchaitoff), Nora Taranto (@norataranto), & Matt Watto (@doctorwatto).Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMECredits Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP Cover Art: Nora Taranto MD, MSCE Reviewer: Sai S Achi MD, MBA, FACP Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT  Weight Regain after Weight loss  VALAD – Valacyclovir in patients with early Alzheimer's  Nudges to increase Deprescribing  Outro Sponsor: MedStudy Qbank Study less. Remember more. Pass confidently.Medstudy.com/CurbsidersCURB15 for 15% offSponsor: FIGSWe've teamed up with FIGS, and now Curbsiders listeners can get 15% off at Wearfigs.com with code FIGSRX. Sponsor: QuinceRight now, go to Quince.com/curb for free shipping and 365-day returns. Sponsor: A Dangerous DiagnosisTo get 20% off use DIAGNOSIS20 at www.penguinrandomhouse.com/books/808848/a-dangerous-diagnosis-by-shantanu-rai/paperback/

Support your health journey with our private practice! Explore comprehensive lab testing, functional assessments, and expert guidance for your wellness journey. Find exclusive offers for podcast listeners at nutritionwithjudy.com/podcast. _____**Podcast Update: It looks like I accidentally switched the terms: absolute risk reduction vs relative risk reduction. Regardless of the terminologies, the point was to see what funny games statisticians will use for marketing pharma drugs (and this happens in a lot of types of marketing...) To see a clear write-up of the absolute risk vs relative risk, you can read an article I shared about it: https://www.nutritionwithjudy.com/old-newsletter/why-statins-dont-stop-heart-attacks/In this episode, I walk through why statins are prescribed (especially with LDL above 190 mg/dL or with type 2 diabetes), and I explain how statin marketing can make the benefits look bigger than they really are by using relative risk instead of absolute risk. I also cover major concerns I see with statins, including nutrient depletion (like CoQ10) and potential impacts on muscle function over time. Make sure to listen to the full interview to learn more.The statin numbers (the what, why)Lipitor ad: relative vs absolute risk reductionStatin efficacy studies (and risks)Statins reduce nutrient status (including CoQ10)Risks of low cholesterolWhat to test and track for heart diseaseNew book cover _____EPISODE RESOURCES Join the NewsletterCarnivore Diet Cholesterol Labs Cardiovascular Blood TestStatin Use Is Associated With a Decline in Muscle Function and Mass Over Time (PubMed)Should You Take a Statin for Your High Cholesterol? (Yale Medicine)Lipitor Ad Highlighting Relative Risk Reduction (36%) vs Absolute Risk (3% vs 2%) (ResearchGate Figure)Atorvastatin Decreases Blood Coenzyme Q10 in Patients at Risk for CVD and Stroke (JAMA/Arch Neurol)Lipitor: Why It Remains the Best-Selling Drug in Pharmaceutical History (Accio)Heart Statistics: Cardiovascular Disease Statistics for the UK (British Heart Foundation)WHO Mortality Database (World Health Organization)Robert Jarvik (Artificial Heart Developer) (Wikipedia)Pfizer, Lipitor (atorvastatin calcium) print advertisement featuring Robert Jarvik, ca. 2006–2008.____FIND JUDY CHO⛑️Work with Us: https://empowerfunctionalhealth.com/services/

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3317: Nancy Clark reminds us that even fit, “skinny” athletes aren't immune to heart disease, and that no one can out-exercise a poor diet. Drawing from the American Heart Association's latest guidelines, she explains how simple, sustainable eating patterns support not only long-term heart health but also peak athletic performance. Learn how small daily choices, from whole grains to healthy fats, can protect your heart while fueling miles of smiles. Read along with the original article(s) here: https://nancyclarkrd.com/2022/02/11/yes-even-athletes-get-heart-disease/ Quotes to ponder: “No one can out-exercise a bad diet.” “Given cardiovascular disease (CVD) starts in the womb, adopting heart-healthy eating patterns early and maintaining them throughout one's life is important.” “Replacing hard-at-room-temperature saturated fats (butter, coconut oil) with soft-or-liquid polyunsaturated and monounsaturated fats, has robust scientific evidence of protecting against heart disease by lowering bad LDL cholesterol.” Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3317: Nancy Clark reminds us that even fit, “skinny” athletes aren't immune to heart disease, and that no one can out-exercise a poor diet. Drawing from the American Heart Association's latest guidelines, she explains how simple, sustainable eating patterns support not only long-term heart health but also peak athletic performance. Learn how small daily choices, from whole grains to healthy fats, can protect your heart while fueling miles of smiles. Read along with the original article(s) here: https://nancyclarkrd.com/2022/02/11/yes-even-athletes-get-heart-disease/ Quotes to ponder: “No one can out-exercise a bad diet.” “Given cardiovascular disease (CVD) starts in the womb, adopting heart-healthy eating patterns early and maintaining them throughout one's life is important.” “Replacing hard-at-room-temperature saturated fats (butter, coconut oil) with soft-or-liquid polyunsaturated and monounsaturated fats, has robust scientific evidence of protecting against heart disease by lowering bad LDL cholesterol.” Learn more about your ad choices. Visit megaphone.fm/adchoices

I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn Editor in Chief of Kidney International Case ReportsAnna Gaddy (@AnnaGaddy) Winner of NephJC Rookie of the Year 2020Nayan Arora (@CaptainChloride.bsky.social)AC (@medpeedskidneys.bsky.social)Vipin Verghese (@vipvargh.bsky.social) co-winner of NephJC Engaged Scientist of the Year in 2021Brian Rifkin (@brianrifkin.bsky.social) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021Cristina Popa (@NephroSeeker) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023Editing and Show Notes byAnna Gaddy and Joel TopfThe Kidney Connection written and performed by Tim YauShow NotesTop Stories in Nephrology 2025 (NephJC)First Top sories in Nephrology 2010! (Renal Fellow Network)Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC)1. IgA NephropathyVISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM)ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM)Aliza M. Thompson, MD, MS (ASN) 2. Lupus NephritisREGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM)3. Nobel prize winner and peripheral immune tolerance4. Xenotransplantation5. GLP1ra RevolutionRemodel REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Kidney International)SURPASS-CVOT Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (Kidney Week abstract in JASN)Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford (KFF survey)6. GDMT implementation in CKD: lessons learnt from CONFIDENCE and MIRO-CKDConfidence Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (NEJM)MIRO-CKD Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial (The Lancet)7. Flozin Meta analysisSMART-C. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria. A Meta-Analysis (JAMA)SMART-C. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria. A Meta-Analysis (JAMA)8. Paradigm Shift: Aiming for CKD Remission9. Fish Oil and DialysisPISCES Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)10. Decline in Dialysis Patients in the United StatesUSRD 2025 Annual Data Report (USRDS)Tubular SecretionSwapnil Hiremath Alien Earth on FX Hulu (Wikipedia)AC A Christmas Carol by Charles Dickens (Wikipedia) and The Muppet Christmas Carol (Wikipedia)Anna Monty Don (Wikipedia)Nayan Back Street Boys at The Sphere (Wikipedia)Brian Marty Supreme (Wikipedia)Cristina The Yellow Tie (Wikipedia)Vipin Stranger Things, good for a four year old? (Wikipedia)Joel Crash Course: The Universe with Katie Mack and John Green (Apple PodCasts)

Program notes:0:45 Impact on kids of parental firearm injury or death1:46 Eight additional psychiatric diagnoses per 100,0002:39 Lifetime stress, inflammation and racial disparities in mortality3:40 Black individuals shorter survival4:40 Precise number is difficult to understand5:40 Self-report6:45 If a woman has known CVD, can she discontinue statins in pregnancy?7:45 No difference in woman's health8:45 Over a 14-year period9:00 Policy compliance in leading tobacco brands10:00 Instagram, FTC and FDA policies11:00 Cut across all types of nicotine products12:59 End

Beat Heart Disease Before It Starts — Insights from Dr. Howard Elkin with Dr. Ben Weitz. Dr. Elkin's website is Heartwise.com.  His main office is in Whittier, California and he has a concierge practice in Santa Monica, California and his office number is 562-945-3753. What You'll Hear In This Episode: 02:40    A Functional Medicine approach looks at why the body would lay down plaque as a rational response to coat the artery wall against inflammation or oxidation or glycation reactions. 06:08    I asked Dr. Elkin what his view is on cholesterol and he mentioned that half of patients who have heart attacks have normal cholesterol 08:09    Dr. Elkin discusses the benefits of the Boston Heart Lab and other advanced lipid profiles for better assessing true CVD risk 09:36    Howard explains how small, dense particles are more likely to be oxidized and incorporated into arterial plaques 10:50     I explained how larger HDL particles perform reverse cholesterol transport to remove potentially harmful LDL particles from the blood stream 11:02     I asked how Dr. Elkin treats patients who have small, dense LDL particles and he explained that he gets his patients to change their lifestyle and he uses certain nutritional supplements such as niacin before he puts them on medications.   13:10     I asked Howard what are some of the most important dietary factors to change to lower cardiovascular risk in such a patient?  He said it's not about cutting our eggs and saturated fat, like we used to think.  Howard's way of thinking is that sugar not fat is the main villian, since it is pro-inflammatory. 16:57    I asked Dr. Elkin about one of his recent blog articles where he wrote about the new PCSK-9 inhibitor medications for cholesterol. Dr. Elkin explained these may be effective, but they showed that they could bring LDL cholesterol levels down to 36 and this is actually not a good thing, since you need cholesterol for hormones, vitamin D production, and brain function.   Also, these drugs cost $14,000 per year. 20:30   Howard explained that when he does places patients on statins, he always puts them on CoQ10 to prevent muscle problems. He usually uses 100-200 mg to start with.  With patients who have heart failure he will use very high dosages, along with magnesium, L-Carnitine, and D-Ribose. 24:22   Dr. Elkin discusses what nutritional supplements he will use to raise HDL levels: 2 tablespoons daily of Extra Virgin Olive oil,  coconut oil, low carb diet, exercise, weight reduction, and niacin. 27:52    I asked Howard how to lower Lp(a). He said that this fragment of LDL is extremely atherogenic and is highly likely to get oxidized. Niacin, estrogen, and fish oil can help. I mentioned that I also found that berberine and tocotrienols were also helpful. 30:30   We discussed what to do about patients with elevated CRP (indicative of inflammation). Dr. Elkin mentioned that this test should be done routinely on all patients, but it is often not measured.  There is a link between obesity and CRP and also between oral cavity problems and sinusitis and even poor sleep. He likes fish oil, turmeric, ginger, and boswellia to reduce inflammation.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Layne Norton is a nutrition scientist and accomplished power athlete,who returns to The Drive for a conversation that departs from the show's usual format. In this episode, Layne presents the evidence-based case that seed oils are not uniquely harmful under isocaloric conditions, while Peter steelmans the strongest versions of the opposing argument that seed oils are inherently harmful. They examine how scientific bias and evidence are evaluated, revisit the historical randomized controlled trials that shaped the seed oil controversy, and explore the mechanistic biology underlying LDL oxidation and atherosclerosis. Along the way, Layne unpacks the chemistry and processing of modern seed oils, assesses evolutionary and ancestral nutrition arguments, clarifies the relationship between seed oils, ultra-processed foods, and contemporary dietary patterns, and situates these questions within the larger context of lifestyle factors that drive cardiometabolic health. Layne concludes by offering practical considerations around dietary fats, cooking oils, and real-world food choices. We discuss: The idea behind this episode, biases, and evidence-based thinking [5:15]; The four core arguments behind claims that seed oils are harmful [12:30]; The Minnesota Coronary Experiment (MCE) [14:30]; The differences among saturated, monounsaturated, polyunsaturated, and trans fats, and why those differences matter for cardiovascular disease [18:30]; Missing trans fat data as a confounder in the Minnesota Coronary Experiment, other limitations of that study, and the challenge detecting meaningful differences in hard outcomes through nutrition research [24:00]; The Sydney Diet Heart Study (SDHS): an attempt to address the "duration problem" by enrolling a much higher-risk population [28:30]; Debating whether evidence from randomized trials supports the idea that seed oils are uniquely harmful once major confounders are removed [34:00]; The Rose Corn Oil trial: an often-cited study used to argue against polyunsaturated fats [36:30]; Three studies where replacing saturated fat with polyunsaturated fat produced different results than earlier trials [41:30]; Layne's explanation for why the evidence is pointing towards cardiovascular risk reduction when substituting polyunsaturated fat for saturated fat [47:30]; What Mendelian randomization says about the causal role of LDL cholesterol in ASCVD [56:45]; The compounding effects of life-long exposure to high LDL cholesterol [1:06:45]; Does the linoleic acid (omega-6) content of seed oils cause inflammation? [1:13:45]; Does the linoleic acid (omega-6) content of seed oils increase oxidized LDL? [1:19:30]; Layne's analogy to explain why lower LDL particle number outweighs higher per-particle oxidation risk when comparing polyunsaturated fats to saturated fats [1:26:15]; The role of oxidized LDL in CVD: exploring differences in a diet high in polyunsaturated fat (seed oils) versus high in saturated fat [1:28:00]; Examining whether industrial processing and solvent extraction of seed oils—especially residual hexane—could plausibly cause long-term harm [1:34:00]; The evolutionary and "ancestral diet" argument against seed oils [1:40:45]; Weighing concerns about industrial processing of seed oils against the totality of metabolic and cardiovascular evidence [1:47:30]; Practical considerations around dietary fats, cooking oils, and real-world food choices [1:50:00]; Comparing the health impact of seed oils with that of caloric intake and activity levels, and how to prioritize interventions [2:00:15]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

This is a recap of the top 10 posts on Hacker News on January 07, 2026. This podcast was generated by wondercraft.ai (00:30): Creators of Tailwind laid off 75% of their engineering teamOriginal post: https://news.ycombinator.com/item?id=46527950&utm_source=wondercraft_ai(01:50): US will ban Wall Street investors from buying single-family homesOriginal post: https://news.ycombinator.com/item?id=46531068&utm_source=wondercraft_ai(03:10): Sugar industry influenced researchers and blamed fat for CVD (2016)Original post: https://news.ycombinator.com/item?id=46526740&utm_source=wondercraft_ai(04:31): Eat Real FoodOriginal post: https://news.ycombinator.com/item?id=46529237&utm_source=wondercraft_ai(05:51): Shipmap.orgOriginal post: https://news.ycombinator.com/item?id=46527161&utm_source=wondercraft_ai(07:11): A4 Paper StoriesOriginal post: https://news.ycombinator.com/item?id=46525888&utm_source=wondercraft_ai(08:32): LaTeX Coffee Stains (2021) [pdf]Original post: https://news.ycombinator.com/item?id=46526933&utm_source=wondercraft_ai(09:52): US Job Openings Decline to Lowest Level in More Than a YearOriginal post: https://news.ycombinator.com/item?id=46527533&utm_source=wondercraft_ai(11:12): Tailscale state file encryption no longer enabled by defaultOriginal post: https://news.ycombinator.com/item?id=46531925&utm_source=wondercraft_ai(12:33): Polymarket refuses to pay bets that US would 'invade' VenezuelaOriginal post: https://news.ycombinator.com/item?id=46521773&utm_source=wondercraft_aiThis is a third-party project, independent from HN and YC. Text and audio generated using AI, by wondercraft.ai. Create your own studio quality podcast with text as the only input in seconds at app.wondercraft.ai. Issues or feedback? We'd love to hear from you: team@wondercraft.ai

I know the title sounds bad. But really it's focusing on the next step in life. Here is the livestream that I did , ( note all giveaways are done.) I had a blast doing a year in review, and whats in the future. Hope you enjoy and know that i'm trying to produce the best product I can. Anyway Be Blessed.Badmotivatorbarrels.com/shop/?aff=3 https://www.instagram.com/zsmithwhiskeyandmixology?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==Death is the end of life, the irreversible cessation of all biological functions that sustain a living organism.[3] Death eventually and inevitably occurs in all organisms. The remains of a former organism normally begin to decompose shortly after death.[4] Some organisms, such as the immortal jellyfish, are biologically immortal; however, they can still die from means other than the effects of aging.[5] Death is generally applied to whole organisms; the equivalent for individual components of an organism—such as cells or tissues—is necrosis.[6] Something that is not considered an organism may be said "to die" in a figurative sense when it reaches an inactive state, such as when a star runs out of fuel.As of the early 21st century, 56 million people die per year. As of 2022, an estimated total of almost 110 billion humans have died, or roughly 94% of all humans to have ever lived.[7] The cause of death is usually considered important, and an autopsy can be done to determine it. There are many causes, from accidents to diseases. The most common reason is aging;[8] the most common cause is cardiovascular disease (CVD), which is a disease that affects the heart or blood vessels.[9] A substudy of gerontology known as biogerontology seeks to eliminate death by natural aging in humans, often through the application of natural processes found in certain organisms.[10] However, as humans do not have the means to apply this to themselves, they have to use other ways to reach the maximum lifespan for a human, often through lifestyle changes, such as calorie reduction, dieting, and exercise.[11] The idea of lifespan extension is considered and studied as a way for people to live longer.Determining when a person has definitively died has proven difficult. Initially, death was defined as occurring when breathing and the heartbeat ceased, a status still known as clinical death.[12] However, the development of cardiopulmonary resuscitation (CPR) meant that such a state was no longer strictly irreversible.[13] For all organisms with a brain, death can instead be focused on this organ.[14][15] Brain death was then considered a more fitting option, but several definitions exist for this: some people believe that all brain functions must cease; others believe that even if the brainstem is still alive, the personality and identity are irretrievably lost, so therefore the person should be considered entirely dead.[16] Brain death is sometimes used as a legal definition of death.

Episode 210: Heat Stroke BasicsWritten by Jacob Dunn, MS4, American University of the Caribbean. Edits and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice. Definition:Heat stroke represents the most severe form of heat-related illness, characterized by a core body temperature exceeding 40°C (104°F) accompanied by central nervous system (CNS) dysfunction. Arreaza: Key element is the body temperature and altered mental status. Jacob: This life-threatening condition arises from the body's failure to dissipate heat effectively, often in the context of excessive environmental heat load or strenuous physical activity. Arreaza: You mentioned, it is a spectrum. What is the difference between heat exhaustion and heat stroke? Jacob: Unlike milder heat illnesses such as heat exhaustion, heat stroke involves multisystem organ dysfunction driven by direct thermal injury, systemic inflammation, and cytokine release. You can think of it as the body's thermostat breaking under extreme stress — leading to rapid, cascading failures if not addressed immediately. Arreaza: Tell us what you found out about the pathophysiology of heat stroke?Jacob: Pathophysiology: Under normal conditions, the body keeps its core temperature tightly controlled through sweating, vasodilation of skin blood vessels, and behavioral responses like seeking shade or drinking water. But in extreme heat or prolonged exertion, those mechanisms get overwhelmed.Once core temperature rises above about 40°C (104°F), the hypothalamus—the brain's thermostat—can't keep up. The body shifts from controlled thermoregulation to uncontrolled, passive heating. Heat stroke isn't just someone getting too hot—it's a full-blown failure of the body's heat-regulating system. Arreaza: So, it's interesting. the cell functions get affected at this point, several dangerous processes start happening at the same time.Jacob: Yes: Cellular Heat InjuryHigh temperatures disrupt proteins, enzymes, and cell membranes. Mitochondria start to fail, ATP production drops, and cells become leaky. This leads to direct tissue injury in vital organs like the brain, liver, kidneys, and heart.Arreaza: Yikes. Cytokines play a big role in the pathophysiology of heat stroke too. Jacob: Systemic Inflammatory ResponseHeat damages the gut barrier, allowing endotoxins to enter the bloodstream. This triggers a massive cytokine release—similar to sepsis. The result is widespread inflammation, endothelial injury, and microvascular collapse.Arreaza: What other systems are affected?Coagulation AbnormalitiesEndothelial damage activates the clotting cascade. Patients may develop a DIC-like picture: microthrombi forming in some areas while clotting factors get consumed in others. This contributes to organ dysfunction and bleeding.Circulatory CollapseAs the body shunts blood to the skin for cooling, perfusion to vital organs drops. Combine that with dehydration from sweating and fluid loss, and you get hypotension, decreased cardiac output, and worsening ischemia.Arreaza: And one of the key features is neurologic dysfunction.Jacob: Neurologic DysfunctionThe brain is extremely sensitive to heat. Encephalopathy, confusion, seizures, and coma occur because neurons malfunction at high temperatures. This is why altered mental status is the hallmark of true heat stroke.Arreaza: Cell injury, inflammation, coagulopathy, circulatory collapse and neurologic dysfunction. Jacob: Ultimately, heat stroke is a multisystem catastrophic event—a combination of thermal injury, inflammatory storm, coagulopathy, and circulatory collapse. Without rapid cooling and aggressive supportive care, these processes spiral into irreversible organ failure.Background and Types:Arreaza: Heat stroke is part of a spectrum of heat-related disorders—it is a true medical emergency. Mortality rate reaches 30%, even with optimal treatment. This mortality correlates directly with the duration of core hyperthermia. I'm reminded of the first time I heard about heat stroke in a baby who was left inside a car in the summer 2005. Jacob: There are two primary types: -nonexertional (classic) heat stroke, which develops insidiously over days and predominantly affects vulnerable populations like children, the elderly, and those with chronic illnesses during heat waves; -exertional heat stroke, which strikes rapidly in young, otherwise healthy individuals, often during intense exercise in hot, humid conditions. Arreaza: In our community, farm workers are especially at risk of heat stroke, but any person living in the Central Valley is basically at risk.Jacob: Risk factors amplify vulnerability across both types, including dehydration, cardiovascular disease, medications that impair sweating (e.g., anticholinergics), and acclimatization deficits. Notably, anhidrosis (lack of sweating) is common but not required for diagnosis. Hot, dry skin can signal the shift from heat exhaustion to stroke. Arreaza: What other conditions look like heat stroke?Differential Diagnosis:Jacob: Presenting with altered mental status and hyperthermia, heat stroke demands a broad differential to avoid missing mimics. -Environmental: heat exhaustion, syncope, or cramps. -Infectious etiologies like sepsis or meningitis must be ruled out. -Endocrine emergencies such as thyroid storm, pheochromocytoma, or diabetic ketoacidosis (DKA) can overlap. -Neurologic insults include cerebrovascular accident (CVA), hypothalamic lesions (bleeding or infarct), or status epilepticus. -Toxicologic culprits are plentiful—sympathomimetic or anticholinergic toxidromes, salicylate poisoning, serotonin syndrome, malignant hyperthermia, neuroleptic malignant syndrome (NMS), or even alcohol/benzodiazepine withdrawal. When it comes to differentials, it is always best to cast a wide net and think about what we could be missing if this is not heat stroke. Arreaza: Let's say we have a patient with hyperthermia and we have to assess him in the ER. What should we do to diagnose it?Jacob: Workup:Diagnosis is primarily clinical, hinging on documented hyperthermia (>40°C) plus CNS changes (e.g., confusion, delirium, seizures, coma) in a hot environment. Arreaza: No single lab confirms it, but targeted testing allows us to detect complications and rule out alternative diagnosis. Jacob: -Start with ECG to assess for dysrhythmias or ischemic changes (sinus tachycardia is classic; ST depressions or T-wave inversions may hint at myocardial strain). -Labs include complete blood count (CBC), comprehensive metabolic panel (electrolytes, renal function, liver enzymes), glucose, arterial blood gas, lactate (elevated in shock), coagulation studies (for disseminated intravascular coagulation, or DIC), creatine kinase (CK) and myoglobin (for rhabdomyolysis), and urinalysis. Toxicology screen if history suggests. Arreaza: I can imagine doing all this while trying to cool down the patient. What about imaging?-Imaging: chest X-ray for pulmonary issues, non-contrast head CT if neurologic concerns suggest edema or bleed (consider lumbar puncture if infection suspected). It is important to note that continuous core temperature monitoring—via rectal, esophageal, or bladder probe—is essential, not just peripheral skin checks. Arreaza: TreatmentManagement:Time is tissue here—initiate cooling en route, if possible, as delays skyrocket morbidity. ABCs first: secure airway (intubate if needed, favoring rocuronium over succinylcholine to avoid hyperkalemia risk), support breathing, and stabilize circulation. -Remove the patient from the heat source, strip clothing, and launch aggressive cooling to target 38-39°C (102-102°F) before halting to prevent rebound hypothermia. -For exertional cases, ice-water immersion reigns supreme—it's the fastest method, with immersion in cold water resulting in near-100% survival if started within 30 minutes. -Nonexertional benefits from evaporative cooling: mist with tepid water (15-25°C) plus fans for convective airflow. -Adjuncts include ice packs to neck, axillae, and groin; -room-temperature IV fluids (avoid cold initially to prevent shivering); -refractory cases, invasive options like peritoneal lavage, endovascular cooling catheters, or even ECMO. -Fluid resuscitation with lactated Ringer's or normal saline (250-500 mL boluses) protects kidneys and counters rhabdomyolysis—aim for urine output of 2-3 mL/kg/hour. Arreaza: What about medications?Jacob: Benzodiazepines (e.g., lorazepam) control agitation, seizures, or shivering; propofol or fentanyl if intubated. Avoid antipyretics like acetaminophen. For intubation, etomidate or ketamine as induction agents. Hypotension often resolves with cooling and fluids; if not, use dopamine or dobutamine over norepinephrine to avoid vasoconstriction. Jacob: What IV fluid is recommended/best for patients with heat stroke?Both lactated Ringer's solution and normal saline are recommended as initial IV fluids for rehydration, but balanced crystalloids such as LR are increasingly favored due to their lower risk of hyperchloremic metabolic acidosis and AKI. However, direct evidence comparing the two specifically in the setting of heat stroke is limited. Arreaza: Are cold IV fluids better/preferred over room temperature fluids?Cold IV fluids are recommended as an adjunctive therapy to help lower core temperature in heat stroke, but they should not delay or replace primary cooling methods such as cold-water immersion. Cold IV fluids can decrease core temperature more rapidly than room temperature fluids. For example, 30mL/kg bolus of chilled isotonic fluids at 4 degrees Celsius over 30 minutes can decrease core temperature by about 1 degree Celsius, compared to 0.5 degree Celsius with room temperature fluids. Arreaza: Getting cold IV sounds uncomfortable but necessary for those patients. Our favorite topic.Screening and Prevention:-Heat stroke prevention focuses on public health and individual awareness rather than routine testing. -High-risk groups—elderly, children, athletes, laborers, or those on impairing meds—should acclimatize gradually (7-14 days), hydrate preemptively (electrolyte solutions over plain water), and monitor temperature in exertional settings. -Communities during heat waves need cooling centers and alerts. -For clinicians, educate patients with CVD or obesity about early signs like dizziness or nausea. -No formal "screening" exists, but vigilance in EDs during summer surges saves lives. -Arreaza: I think awareness is a key element in prevention, so education of the public through traditional media like TV, and even social media can contribute to the prevention of this catastrophic condition.Jacob: Ya so heat stroke is something that should be on every physician's radar in the central valley especially in the summer time given the hot temperatures. Rapid recognition is key. Arreaza: Thanks, Jacob for this topic, and until next time, this is Dr. Arreaza, signing off.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! References:Gaudio FG, Grissom CK. Cooling Methods in Heat Stroke. J Emerg Med. 2016 Apr;50(4):607-16. doi: 10.1016/j.jemermed.2015.09.014. Epub 2015 Oct 31. PMID: 26525947. https://pubmed.ncbi.nlm.nih.gov/26525947/.Platt, M. A., & LoVecchio, F. (n.d.). Nonexertional classic heat stroke in adults. In UpToDate. Retrieved September 7, 2025, from https://www.uptodate.com/contents/nonexertional-classic-heat-stroke-in-adults. (Key addition: Emphasizes insidious onset in at-risk populations and the role of urban heat islands in exacerbating classic cases.) Heat Stroke. WikEM. Retrieved December 3, 2025, from https://wikem.org/wiki/Heat_stroke. (Key additions: Details on cooling rates for immersion therapy, confirmation that anhidrosis is not diagnostic, and fluid titration to urine output for rhabdomyolysis prevention.)Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. 

Welcome to part two of our Best of 2025 series - the moments that changed how our listeners think about their health and what they do on a day-to-day basis. In this episode, we delve into simple questions with profound impact. Is it safe to experiment with your own health? Does cheese really cause bad dreams? Why do some breakfasts leave you tired and hungry, while others don't?  If you're looking for practical, science-led ideas you can take into the year ahead, this episode brings together the insights listeners found most useful, surprising, and worth returning to. Unwrap the truth about your food

In this high-impact solo episode, Darin strips away the noise, hacks, and hype to deliver a clear, no-BS roadmap for transforming your body, brain, energy, and direction in life. This is a straight-talk breakdown of the 5 foundational habits that matter most — the habits backed by science, ancient wisdom, and Darin's decades-long experience living this work every day. Expect practical steps, micro-experiments, timing rules, and the mindset needed to reclaim sovereignty in a world full of distraction. If you're ready to build a stronger, clearer, more powerful version of yourself… this is the episode.     What You'll Learn 00:00 – Welcome to SuperLife How this podcast helps you build sovereignty through real habits, real truth, and real practices. 03:07 – Why this episode is different Darin lays out the mission: habits, hacks, hard truths — without dogma or fluff. 03:44 – The 5 foundational moves that change your biology A preview of the metabolic, physical, mental, and behavioral levers that create huge shifts.     1. METABOLIC EDGE — Eat Like You're Building a Future 04:03 – Terrain theory + why your food timing matters How altering the internal environment of your cells changes everything. 05:02 – The two levers that unlock metabolic health Time-restricted eating + plant-forward whole foods. 05:23 – Compressing your eating window Why 8–10 hours is ideal, how it improves glucose, insulin, weight, and inflammation. 06:18 – Practical weekly ramp-up Week 1: 12 hours. Week 2: 8–10 hours. Simple, sustainable, achievable. 07:10 – Darin's personal eating window 10 a.m. to 6 p.m. — and why eating earlier aligns with digestive fire.     2. MOVEMENT THAT MATTERS — Strength Is Survival 11:04 – Why strength training is non-negotiable Muscle protects metabolism, bone density, insulin sensitivity, and longevity. 11:51 – What the evidence says Huge cohort studies show strength training reduces all-cause mortality. 12:23 – The perfect weekly formula 3x/week compound lifts + daily movement + micro-bursts every hour. 13:06 – Real-life practicality Darin's routine of walking, sprinting dogs, mountain biking, and breaking up the day with movement.     3. SLEEP — The Ultimate Biological Reset 16:26 – The truth everyone ignores You cannot out-supplement or out-biohack poor sleep. 16:40 – The real impact of chronic sleep loss Cognition, memory, hormones, emotional regulation — all decline. 17:37 – The universal rule: consistent timing Same bedtime ± 30 minutes, every night. 17:52 – 60-minute wind-down protocol Screens off, light down, nervous system softening. 18:32 – Using sauna as a down-regulation tool Infrared benefits + why Darin does it twice a day in winter.     4. MINDSET & CONSCIOUSNESS — Your Attention Is Your Power 20:00 – Why optimization fails without attention training You can master food, workouts, and sleep — but scattered attention destroys progress. 20:48 – Darin's morning protocol Water → elixir → infrared pad → meditation → visualization → journaling. Every day. Everywhere. 21:01 – Meta-analysis proof Meditation reduces anxiety, depression, stress — and rewires your brain. 21:23 – The perfect 10-minute breathwork formula 5–5–5–5 or 4–4–4–4 cycles for nervous system reset. 21:56 – Journaling as medicine Stream-of-consciousness to activate clarity and emotional release.     5. WEALTH — Treat Your Time Like Capital 22:36 – Redefining wealth It's not money — it's your magnetism, output, relationships, and purpose. 23:16 – The compounding effect of tiny decisions Time batching, micro-actions, and protecting your attention from the social media attention economy. 24:02 – Mini productivity framework 90 seconds → 3 important calls. Every Friday → 1 paragraph on what scaled this week. 25:14 – Darin's post-meditation rule No scrolling — replace with proactive actions: reading, outreach, Patreon replies.     FINAL TAKEAWAYS 26:02 – The master checklist: • Time-restricted eating • Plant-focused meals • Resistance training • Daily meditation • Consistent sleep • Sauna recovery • Treating time like capital 26:11 – The real danger Chasing hacks before mastering fundamentals leads to burnout, confusion, and stress. 27:58 – Your power is in the basics These are simple, accessible, and life-changing. 28:04 – Closing message "Have your best Super Life Day ever."     Thank You to Our Sponsors Our Place: Toxic-free, durable cookware that supports healthy cooking. Go to their website at fromourplace.com/darin and get 35% off sitewide in their largest sale of the year. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.     Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway "Your biology changes when your decisions change. Nail your sleep, nail your strength, honor your attention, and treat your time like capital — and you will build a Super Life from the ground up."     Bibliography Time-restricted eating (human RCTs / reviews) — Wilkinson et al., 10-hour TRE reduced weight and improved cardiometabolic markers (2019). PMC  Intermittent fasting / metabolic health review — comprehensive reviews showing metabolic switching benefits. PMC+1  Plant-forward/vegetarian diets & cardiometabolic outcomes — BMJ/Nutrition reviews and JAMA network evidence showing improved CVD risk markers and metabolic benefits. BMJ Nutrition+1  Sleep and cognition / brain health — Nature/Harvard coverage & meta-analyses: short sleep impairs cognition and links to amyloid processes. Nature+1  Resistance training & mortality / physical function — systematic and cohort evidence that muscle-strengthening activity lowers risk and preserves function. British Journal of Sports Medicine+1  Mindfulness & mental health meta-analysis — Goyal et al. 2014 and subsequent meta-analyses showing reductions in anxiety/stress. PubMed+1  Sauna bathing and cardiovascular outcomes — JAMA Internal Medicine / Mayo Clinic Proceedings reviews on sauna and lower CVD risk signals.

Program notes:0:40 CVD risk factors and texting1:40 How many undergo screening?2:41 Impact of personalized messaging3:25 Decentralized trials versus centralized 4:25 Decentralized much larger5:25 Does the trial move in one way or another?6:15 Two studies related to use of peripregnancy GLP-1 use7:15 Stopping at pregnancy8:15 Is overweight worse than stopping?9:00 Machine learning model, tissues, genetics and age10:00 Practical for assessing genetic basis11:00 Sequential tissue samples11:57 End

In the December 2, 2025 episode of JACC This Week, Editor-in-Chief Harlan M. Krumholz, MD, SM, introduces the Spotlight Issue, anchored by the manuscript "Global, Regional, and National Burden of Cardiovascular Disease and Risk Factors in 204 Countries and Territories, 1990–2023." Listen here as he reviews the issue and gives listeners perspective on the issue as a whole, which contains 19 viewpoints providing perspectives from experts around the world, plus his editor's page, aligned with a talk given at the UN with JACC Editor Emeritus Valentin Fuster, MD, and author Gregory A. Roth, MD. Other perspectives include: CVD in Sub-Saharan Africa; access to essential medicines and technologies; confronting inequities in pediatric cardiac care; and perspectives from Japan, Canada, the Middle East & North Africa, South America, Pakistan, and many others.  Listen to the podcast and then check out the full issue online here: https://www.jacc.org/toc/jacc/86/22.

Screening, evaluation, and CVD risk assessment

Elevated Lipoprotein(a) or Lp(a) is increasingly recognized as a significant, independent risk enhancer for cardiovascular disease (CVD). This course explores the evolving landscape of Lp(a) in clinical practice, emphasizing the importance of Lp(a) testing in comprehensive cardiovascular risk assessment. The safety and efficacy of current and emerging lipid-lowering therapies, with a focus on novel agents targeting Lp(a) reduction will be examined.  Claim CE and MOC credits: https://bit.ly/4r1xjU6

Connection can be the key to health, and those facing disconnection are at significantly higher risk of CVD, stroke, T2D, and other health issues. Guest Lora Peppard, PhD, DNP, PMHNP-BC, describes the importance of relationships and the 6 core beliefs that can help our patients and ourselves have improved health.Resources:Related PCNA CE course: https://pcna.net/course/the-extraordinary-impact-of-connection-on-mental-and-cardiovascular-health/Our Epidemic of Loneliness and Isolation: https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdfhttps://www.julianneholtlunstad.com/ https://bronnieware.com/regrets-of-the-dying/ https://www.zachmercurio.com/https://publichealth.jhu.edu/faculty/3038/christina-d-bethell Family Resilience Connection Index: https://nurtureconnection.org/child-flourishing-a-critical-indicator-for-erh/ American Psychiatric Nurses Association https://www.apna.org/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬Sophia Ambruso @sophia-kidney.bsky.socialNayan Arora @captainchloride.bsky.socialSpecial Guests Brian Rifkin @brianrifkin.bsky.socialAnna Gaddy @AnnaGaddyEditing and Show Notes byJoel TopfThe Kidney Connection written and performed by Tim YauShow NotesBrian Rifkin and Cristina Popa ascend to co-editors in chief of NephJC.Paresh Jadav receives the first NephJC Champion award. Dr. Jadav hosted the NephJC night and saved NephJC thousands of dollars. It makes a huge difference in our fund raising. Thank you.Also a big thank-you to Jade Teakell for buying the cowboy hats!The first pick of the draft, by Sophia is Fish oil for dialysis: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)The second pick, by Brian is FINE-ONE (Bayer Press release)Rajiv Agarwal's mediation analysis to show how much of finerenone's beneficial renal effects are captured by the reduction proteinuria: Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis (PubMed)Anna has the third pick and it goes to Katherine Tuttle and the REM0DEL Trial: REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Science Direct)Nayan goes off-board and picks a poster by a med student (backed by Testani)Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure (ClinicalTrials.gov)For the final pick in the draft Joel went with a little Lilly on Lilly violence: Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (JASN)Bring out your dead…What's left on the draft board.Liberate-D A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial (JAMA)Atacicept for IgAN A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)Lilia Cervantes crushed it with Community Health Worker Support for Hispanic and Latino Individuals Receiving Hemodialysis: The Navigate-Kidney Randomized Clinical Trial (JAMA)Tubular SecretionBrian: Late Breaking and High Impact Clinical Trials. Including Sibe! REGENCY Biopsy Data.Sophia: Flying Home. No, really it's the Electrolyte QuizJoel: The Poster Session, the Quiz Session, and Nayan: Flying to AHA to talk about dual-heart-kidney-transplantAnna: Kidney STARS! and Melanie Hoenig's session on potassium

JACC's November 25, 2025 issue kicks off Thanksgiving week with JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, reflecting on his editor's page and the day he became a doctor (0:12).  For original research articles, he discusses a study on colchicine & clonal hematopoiesis, an exploratory study of the LoDoCo2 trial (1:10), and a paired editorial comment with more perspectives and a reminder of the upcoming COLCOT trial (4:33). Next, a study on Lp(a) and IL-6 (4:54) and an editorial (6:12), 30-year CVD risk percentiles based on the PREVENT equations (6:30), and an accompanying editorial from JACC Deputy Editor Erica Spatz, MD, on next-generation strategies to encourage healthier behaviors (7:35).  Other studies and editorials include a fascinating look at alcohol and blood pressure (8:04) and reinforcing the WHO public health guidance (10:05); remnant cholesterol in young adults (10:38) and implications for cholesterol guidelines (12:36). We also include four brief reports on RSV vaccine (13:11), long Covid (13:43), Lp(a) levels (14:06), the predictive power of polygenic risk scores (14:58), a viewpoint on US veterans (15:36), and our regular Amara Yad image (15:53), which we're delighted to be able to continue to promote with JACC: Clinical Electrophysiology Editor-in-Chief Kalyanam Shivkumar, MD.  

Screening, evaluation, and CVD risk assessment Medical science has finally recognized the link between chronic, low-grade inflammation and cardiovascular disease! In this episode of Live Foreverish, Dr. Mike and Dr. Crystal share the details on the latest guidelines published by the Americal College of Cardiology which provides action forward steps you can take today to detect and decrease your risk of having a heart attack or stroke. #LELearn #EDULiveforeverish

In this solo episode, Darin reframes one of the most misunderstood forces in life — stress. Instead of seeing it as the enemy, he explores how stress is actually a messenger, guiding you back to alignment, safety, and awareness. Through science, spirituality, and lived experience, Darin breaks down how stress shows us where we're trying to control, where we're disconnected, and where our nervous system is calling for attention. He unpacks the layers of modern stress — from trauma and environment to community and purpose — and offers practical, embodied tools to restore calm, clarity, and resilience.     What You'll Learn 00:00:00 – Welcome to Super Life: Solutions for a Healthier Life and Better World 00:00:32 – Sponsor Spotlight: TheraSauna - Natural Healing Technologies (15% off with code Darrandai) 00:02:10 – The Super Life Podcast: Finding Contentment, Happiness, and Purpose 00:02:51 – Today's Topic: Stress - Reframing Stress as an Ally and Dashboard Light 00:04:54 – The "No Choice" Universe: Reconnecting to Infinite Possibilities 00:05:16 – The Reality of Stress: Statistics and the Impact of Chronic Stress 00:06:21 – Stress is Layered: Beyond a Single Cause, Addressing Chronic Stress 00:08:29 – Solutions for a Super Life: Safety over Calm and the Vagal Response 00:09:38 – The Inner Dialogue Layer: Trauma, Unconsciousness, and Spiritual Bypassing 00:11:47 – The Social Field Layer: Relationships, Community, and Finding Your Way Home 00:14:20 – Sponsor Spotlight: Bite Toothpaste - Sustainable, Non-Toxic Tabs (20% off with code Darin20) 00:16:35 – Creating Your Own Vision: Setting Boundaries with Media and Social Algorithms 00:17:29 – Finding Your Purpose: From Raising Children to Healing Injuries 00:18:35 – Environmental and Existential Stress Layers: Clutter, Noise, and Service 00:19:26 – Stress Load and Resiliency: Why Small Triggers Cause Blow-Ups 00:20:02 – Understanding the Dashboard Light: Acknowledging Unwillingness 00:20:35 – Safety as the Signal: Body Relaxation and Providing Inner Security 00:23:44 – Reframing Trauma: Was it the Protector You Needed at the Time? 00:25:00 – Releasing Trauma: Techniques, The Healing Code, and Waking the Tiger 00:26:06 – Finishing the Survival Response: Shaking, Crying, Screaming, and Stretching 00:26:38 – Stress as a Multiplier: Impact on Immune System, Heart, and Aging 00:28:10 – Stress Slows Repair: Inflammation, Cardiovascular Risk, and Cellular Aging 00:29:48 – The Integrative Approach: Changing Your Environments to Support Anti-Stress 00:30:07 – Actionable Stress Solutions: Circadian Rhythm, Nature, and Noise Reduction 00:30:44 – Actionable Stress Solutions: Gratitude, Conscious Breath, and Movement 00:31:32 – Energy Drains to Eliminate: Conflict, Clutter, Scrolling, and Late Caffeine 00:32:17 – Connecting to Greater Purpose: The Super Life Patreon Platform 00:32:54 – Morning/Night Questions: Letting Go, Creating, and Contributing 00:33:17 – Final Toolkit: Slow Breathing, Movement, Nature, Sauna, and Sleep 00:34:25 – The Invitation: Digging into all Layers of a Super Life on Patreon   Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences   Key Takeaway "Stress isn't your enemy — it's your compass. Every wave of tension points you back to what's asking for care, attention, and love. When you stop fighting stress and start listening to it, you don't just survive — you evolve."       Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756. 

"Organic produce isn't necessarily not sprayed with pesticides. There's different types of pesticides. They just aren't allowed to use synthetic pesticides. Sometimes they can be even more toxic. Sometimes they have to use larger amounts because they're less effective especially given the cost difference between organic and non-organic, I don't see that it's really warranted for something" - Dr. Matthew Nagra Many people still believe that what they eat, how they live, their experiences, and even who they share their life with has no impact on their physical health. Today's guest is out to dispel that. Dr. Matthew Nagra is a Naturopathic Physician, and in case you're wondering if a Naturopathic Physician is a real doctor, Dr. Matthew Nagra is a health practitioner who treats people holistically. He follows a scientific and evidence-based approach to treating ailments.  Dr. Matthew Nagra practices Integrated Health in Vancouver, BC. He has a BSc in Microbiology from the University of Victoria and completed his ND training at the Boucher Institute. He has been vegan for over 10 years, is certified in plant-based nutrition through the T. Colin Campbell Center for Nutrition Studies. He regularly shares information regarding nutrition and health across his social media pages. Learn how to live healthier as you listen to this episode with Dr. Matthew Nagra.  What we discuss in this episode:  First things first, Dotsie shares 3 things she learned from her book-writing retreat What does a Naturopathic Doctor look for when a patient comes for evaluation compared to what a traditional doctor does? The impact of the food you eat, especially dairy products, when you have asthma Dr. Matthew Nagra talks about what he learned from the nutrition debates in school and the studies on saturated fat, LDL, collagen, etc. Refined sugar vs. fruits – What to do when sugar cravings hit  What does raw veganism mean, and how does it relate to a healthy diet? With book recommendation - Becoming Raw: The Essential Guide to Raw Vegan Diets, and Becoming Vegan, both by Brenda Davis Do you know the massive difference between butter and olive oil? How much sodium does your body need if you are healthy? What you need to know about organic food, non-organic food, and GMO The upside and downside of eating eggs and plant-based sources of choline Watch Dr. Matthew Nagra's debates with carnivores: Vegan vs. Carnivore Debate: Saturated Fat and LDL-Cholesterol and Debating LDL-Cholesterol, Saturated Fat, and CVD with a Carnivore Connect with Dr. Matthew Nagra: Website - https://drmatthewnagra.com/ Instagram - https://www.instagram.com/dr.matthewnagra/ Facebook - https://web.facebook.com/dr.matthewnagra/ Twitter - https://twitter.com/drmatthewnagra   Click the link below to support the FISCAL Act https://switch4good.org/fiscal-act/ Share the website and get your resources here https://kidsandmilk.org/ Send us a voice message and ask a question. We want to hear from you! Switch4Good.org/podcast Dairy-Free Swaps Guide: Easy Anti-Inflammatory Meals, Recipes, and Tips https://switch4good.org/dairy-free-swaps-guide SUPPORT SWITCH4GOOD https://switch4good.org/support-us/ ★☆★ JOIN OUR PRIVATE FACEBOOK GROUP ★☆★  https://www.facebook.com/groups/podcastchat ★☆★ SWITCH4GOOD WEBSITE ★☆★ https://switch4good.org/ ★☆★ ONLINE STORE ★☆★ https://shop.switch4good.org/shop/ ★☆★ FOLLOW US ON INSTAGRAM ★☆★ https://www.instagram.com/Switch4Good/ ★☆★ LIKE US ON FACEBOOK ★☆★ https://www.facebook.com/Switch4Good/ ★☆★ FOLLOW US ON TWITTER ★☆★ https://twitter.com/Switch4GoodOrg ★☆★ AMAZON STORE ★☆★ https://www.amazon.com/shop/switch4good ★☆★ DOWNLOAD THE ABILLION APP ★☆★ https://app.abillion.com/users/switch4good

The bidiretional relationship between cardiac and renal systems means that any dysfunction can cause a cascade of health issues. Learn about team-based care strategies for nurses and other professionals to monitor and manage patients with these conditions from guests Andrew Bzowyckyj, PharmD, BCPS, CDCES, FAPhA, FADCES, and Serina Gbaba, DNP, MBA, FNP-BC.PCNA CKM tools and resources: https://pcna.net/resources/patient-education/patient-information/cardiovascular-kidney-metabolic-syndrome-resources/ IPEC core competencies (Interprofessional Education Collaborative): https://www.ipecollaborative.org/ipec-core-competencies CVD in CKD: Pathophysiological Insights and Therapeutic Options: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050686Social Determinants of CVD:https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319811See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mindfulness and Cardiovascular Disease Risk: State of the Evidence, Plausible Mechanisms, and Theoretical FrameworkIn this episode, Dr. Jud Brewer and Dr. Eric Loucks explore the growing body of research on mindfulness and its potential role in reducing cardiovascular disease (CVD) risk. With CVD remaining the leading cause of mortality worldwide, this integrative review examines how mindfulness may impact key risk factors such as smoking, diet, physical activity, obesity, blood pressure, and diabetes regulation. The discussion also unpacks the plausible mechanisms—improved attention control, emotion regulation, and self-awareness—that could explain mindfulness's effects on heart health. Tune in to discover how mindfulness could be a game-changer for preventive cardiology and overall well-being.Full Reference:Loucks, E. B., Schuman-Olivier, Z., Britton, W. B., Fresco, D. M., Desbordes, G., Brewer, J. A., & Fulwiler, C. (2015). Mindfulness and cardiovascular disease risk: State of the evidence, plausible mechanisms, and theoretical framework. Current Cardiology Reports, 17(112). https://doi.org/10.1007/s11886-015-0668-7Let's connect on Instagram

In episode 610, Jamie and James chat with Jennifer Young about yet another Vitamin D Tools for Practice. We look at what happens to mortality, CVD and cancer when Vitamin D supplements are compared to placebo. The results may surprise you – or maybe not if you have listened to previous BS Medicine Podcasts on […]

In this episode, Zach Boyajian returns for a long-awaited Part 2 with futures trader Zach Boyajian. They dive deep into prop firm payouts, SIM farming, overconfidence, and the real cost of copy trading. Zach shares how he went from blowing SIM PRO accounts to balancing personal capital and live prop accounts. He explains why a $20K payout doesn't make you a trader if you lost $15K getting there. The conversation unpacks emotional tilt, overtrading, and the boom-bust cycles that trap most new traders. Zach now trades one high-quality setup a day, focused on risk control and longevity. He breaks down how he uses VWAP, volume profile, and CVD to make sense of the ES and YM chaos. This episode is brutally honest, packed with strategy, and a must-listen for anyone in the prop space.Connect with Zach - https://realdealfutures.com/ Futures Bootcamp Tickets - https://asfx.biz/bootcamp/ Sponsor: Top One FuturesLink: ⁠https://www.asfx.biz/tof⁠Code: ASFX for 50% offSponsor: TradezellaLink: ⁠https://tradezella.com?fpr=asfx⁠Code ASFX for 20% off

The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Is the PREVENT Calculator Best for Determining CVD Risk? Insights From a Post Hoc Analysis of SPRINT Trial https://www.medscape.com/viewarticle/prevent-calculator-best-determining-cvd-risk-insights-post-2025a1000svo PREVENT Calculator https://doi.org/10.1016/j.jacc.2025.07.037 SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939 II GLP-1 Mechanism of Action in CV Disease Analysis of SELECT Trial 10.1016/S0140-6736(25)01375-3 External Link SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 III Statins and CAD Phenotype on CTA and Outcomes Interactions Between Statin Use, CAD Phenotypes on CTA  https://www.jacc.org/doi/10.1016/j.jcmg.2025.05.018 Statin Use for Primary Prevention of CVD https://jamanetwork.com/journals/jama/fullarticle/2795522 IV HHF Endpoints in Heart Failure Trials The Problem with Hospitalization Endpoints in HF Trials https://onlinelibrary.wiley.com/doi/10.1002/ejhf.70070 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Today we're talking about Simon Hill's personal experience with CVD, what prompted him to have early screening for heart disease and what his results have shown. Which is quite surprising.Simon has early signs of heart disease and now he has a decision to make around whether he embarks on early drug treatment or delays treatment to watch how it evolves. As many of us become more pragmatic about health screening, it's a situation that a lot of us will find ourselves in. Especially with the rise in popularity of full body scans.We also have a discussion around fats, the types of fats in the diet and how one may choose to lower their cholesterol with diet and lifestyle.We go on a virtual trip to the supermarket with Simon and discuss the framework for how to choose fats. The things you need to ask yourself about consuming fats, including the dose and what you're eating it with.Simon Hill, a physiotherapist and nutrition scientist, is dedicated to simplifying health and nutrition information. He began his career interested in the physiology and anatomy related to optimal athletic performance. Then, encouraged by his Dad's heart attack, he turned his attention to nutrition's role in preventing disease and optimising health. Concerned about misleading wellness industry trends, he completed a Master of Science in Human Nutrition at Deakin University.

Tune into this podcast from Dr Clíona Ní Cheallaigh to learn how to provide person-centered care for treatment-experienced people with HIV. Gain strategies to address each individual's specific history and needs while considering the potential impact of comorbidities and other health challenges. Topics covered include:Individualizing Antiretroviral Regimens for Treatment-Experienced People With HIVStrategies to Improve Adherence and Addressing Barriers to Engagement in CarePerson-Centered, Trauma-Informed CareResistance Testing in the Setting of Virologic FailureSelection of ARVs With a Failing RegimenPresenters:Clíona Ní Cheallaigh, MB, MRCP, PhDConsultant PhysicianInclusion Health ServicesSt James's Hospital DublinAssociate ProfessorDepartment of MedicineTrinity College DublinDublin, IrelandLink to full program:https://bit.ly/4oiYxExGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Stress isn't just something to “manage” — it's a signal, a teacher, and often, an invitation to look deeper at our health, our choices, and our lives. In this solo episode, Darin reframes stress not as an enemy, but as a dashboard light pointing toward misalignments in our nervous system, environment, relationships, and purpose. Drawing on science, practical tools, and personal insight, Darin reveals how layered stress silently drains our vitality — and how to transform it into an ally for growth, healing, and deeper contentment. Whether it's hidden trauma, toxic environments, unresolved conflict, or the modern distractions constantly pulling at our attention, Darin lays out a roadmap to stop the leaks and reclaim the energy already within you. This episode is a powerful reminder: stress isn't the end of the story — it's the beginning of awareness, safety, and a super life.     What You'll Learn in This Episode [00:00] Introduction to the Super Life podcast [03:27] Why stress might not be your enemy [04:17] Stress as an ally: the signals it gives us about misalignment [04:32] The dashboard light metaphor: how stress reveals hidden issues [05:28] The illusion of “no choice” and the infinite possibilities always available [06:12] Global stress statistics and why most people underestimate their stress load [07:23] Hidden stress revealed through heart rate variability and physiology [08:23] Layered stress: how sleep, exercise, and poor choices compound each other [09:25] Safety vs. calm — why your nervous system craves safety first [10:15] Trauma and the unconscious mind: how old wounds drive our stress response [11:54] Inner narratives and negative self-talk as hidden stress multipliers [12:22] The role of community and your social field in stress and resilience [13:53] Relationships, honesty, and how your circle shapes your energy [14:55] Why boundaries around media and politics are vital for mental clarity [17:42] Finding micro-purpose when life feels overwhelming [18:52] Environmental layers of stress — light, air, and clutter [19:15] The existential layer: stress from living without service or purpose [20:12] Stress as a risk amplifier — how it undermines healing and health [20:55] The deeper truth of safety, connection, and higher power [23:00] Practical tools: breathing, grounding, nature, and conscious choices [24:01] Trauma reframed: not a problem, but a protector at the time [25:25] Lessons from Peter Levine and wild animals: releasing trauma physically [26:04] Questions to ask trauma: “What are you protecting me from?” [26:56] Stress as a multiplier of aging, disease, and poor outcomes [29:20] Why stress isn't a single cause — it's layered and chronic [30:18] Anti-stress strategies: circadian rhythm, nature, and gratitude [31:49] Energy leaks to avoid: clutter, poor food, scrolling, bad boundaries [32:22] What matters most: service, contribution, and alignment [33:28] Final toolkit: breathwork, movement, nature, sleep, and gratitude [34:38] The deeper invitation: step into sovereignty and live your SuperLife     Thank You to Our Sponsors: Manna Vitality: Go to mannavitality.com/  or use code DARIN20 for 20% off your order. Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order.     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Check out my podcast with Dr. Amy Abbington     Key Takeaway “Stress is not the enemy. It's a dashboard light — a teacher showing you where you're out of alignment. When you reframe stress, you reclaim your energy and create space for healing, safety, and the joy of living a super life.”     Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756. 

Program notes:0:53 Who needs a beta blocker after MI1:53 Those with mild reduction of ejection fraction2:53 Confined to those with 40-50% ejection fraction3:15 Revascularization in NSTEMI4:20 Composite outcome5:20 Closes gap, do FFR6:20 May not be physiologically significant6:40 Is lifelong anticoagulation needed after ablation7:41 Occurred less in those who stopped8:30 RSV, cardiac events and hospitalizations9:30 Lower hospitalization in those who got the vaccine10:30 Acute respiratory illness hospitalization11:30 Less benefit with existing CVD or immunocompromise12:15 Several RSV vaccines13:16 End

Episode Highlights With JessicaWhy does cardiovascular disease risk rise in menopause to match the rate of men?What happens to hormones and the heart when a woman goes through menopause?45% of women have some marker of cardiovascular diseaseHow the loss of estrogen in menopause is the tipping point1 in 3 women will die of cardiovascular disease which is more than all cancers combinedWhat to monitor and look out for starting in our 20s50% of people in the US have high blood pressure and this is a marker of metabolic diseaseHow insulin comes into play and why this marker is so importantWhat metabolic markers to start tracking to know your riskHow visceral fat comes into play and why this is importantWhat causes visceral fat to accumulate in the bodyHer take on microdosing GLP-1 medication and if you lose lean muscleResources MentionedThe Loving Diet - websiteJessica's Instagram

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores the complex world of supplements by introducing a practical framework for evaluating their effectiveness and relevance to individual health needs. Rather than providing a simple list of recommendations, Peter aims to equip listeners with the tools to critically assess supplements on their own. He then applies this framework to discuss research on several popular supplements, including creatine, fish oil, vitamin D, B vitamins, and ashwagandha. Additionally, he covers key factors in assessing supplement quality, helping listeners develop a deeper understanding of how to make informed decisions based on their personal health goals. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #69 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Overview of episode topics [1:45]; How Peter evaluates patients' supplement regimens, and common misconceptions about supplements vs. pharmaceuticals [3:00]; A framework for evaluating supplements [6:15]; Evaluating creatine: purpose of supplementation, dosing, and mechanism of action [10:00]; Creatine: proven benefits for muscle performance, potential cognitive benefits, and why women may benefit more [15:15]; Creatine: risk vs. reward, kidney concerns, and choosing the right supplement [18:45]; Evaluating fish oil: its primary purpose as a supplement and how to track levels [20:45]; Fish oil: how omega-3s impact inflammation, heart health, and brain function, and the strengths and limitations of current research [26:30]; Fish oil: the risks of supplementation, guidance on selecting high-quality products, and how to determine whether supplementation is appropriate [37:30]; Evaluating vitamin D: understanding deficiency and optimal levels [45:15]; Vitamin D: role in bone health, immune function, potential longevity impact, and biomarker limitations [51:15]; Vitamin D: efficacy, safety, and balancing risk vs. reward [58:15]; Evaluating B vitamins: function, consequences of deficiency, and key biomarkers to assess whether supplementation is necessary [1:02:15]; B vitamins: risks for CVD and dementia associated with deficiency, and limited evidence for general population supplementation [1:07:15]; Evaluating ashwagandha: background, uses, and mechanism of action [1:15:30]; Ashwagandha: current evidence for its effects on sleep, stress, and anxiety [1:19:15]; Ashwagandha: evaluating supplement quality, safety profile, and the risk-reward balance [1:22:15]; The importance of using a structured evaluation framework to assess any supplement [1:26:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube