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Have you heard of DPP IV? Well this enzymes might be a helpful tool for those with severe gluten intolerances or sensitivities. Check out this part 2 of the enzymes episodes to find out more, and check out my new intro music...totes professional now. Let me know what you think of it! And please share and subscribe to my podcast on your favorite podcast platform if your haven't already.
With chronic conditions affecting almost half of the U.S. population, health experts have started to consider other potential causes of these conditions. Exposure to environmental toxins, stress, trauma, and genetic predispositions can all play a role in the development of certain chronic health conditions, but food sensitivities could also have a big influence. Food sensitivities and allergies are much more common than they used to be, and the symptoms are often minimal or mimic other conditions and can be difficult to diagnose without proper testing. Gluten is one of the more common sensitivities, and we are finding more people have a gluten sensitivity than previously thought. In this week's show we'll discuss some of the potential symptoms and effects a gluten sensitivity could cause to see if gluten could be the hidden cause of your health issues. We'll also go over how to test for food sensitivities, and what you can do to help heal your gut. Products Mentioned in Today's Show GI Support - Provides extensive support for the entire GI tract by addressing energy requirements of intestinal mucosa, structural composition of intestinal and colonic cells, microorganism balance, and production of protective intestinal mucus secretions.† Chewable Digestive Essentials V - This product can assist in the breakdown of a wide range of proteins, peptides, fats, complex carbohydrates, sugars, and fibers.† Serratia peptidase, a unique endopeptidase enzyme, helps protect sensitive GI tissue from irritation that can affect tissue health and intestinal comfort.† Enzymes with DPP-IV activity and a full range of disaccharidases are included.† Probio-Ease - This shelf-stable, 50 billion CFU formulation contains a blend of 7 select probiotic species with Sunfiber®, a low-FODMAP certified prebiotic. This formulation provides comprehensive microbiome, immune, and healthy inflammation support in one convenient capsule.† You can also listen to Is Gluten the Hidden Cause? on our YouTube channel here.
Gut issues are more common than ever, and acid reflux, indigestion, and bloating are a few of the most common complaints. Although you may have suffered with these issues for years, there are several dietary and lifestyle changes you can implement that may help reduce how often you experience them. In this week's episode we'll go over some dietary factors that could contribute to digestive issues, as well as discuss the benefits of digestive enzymes and other supplements designed to support gut health. Products Mentioned in Today's Show Chewable Digestive Essentials V - This product can assist in the breakdown of a wide range of proteins, peptides, fats, complex carbohydrates, sugars, and fibers.† Serratia peptidase, a unique endopeptidase enzyme, helps protect sensitive GI tissue from irritation that can affect tissue health and intestinal comfort.† Enzymes with DPP-IV activity and a full range of disaccharidases are included.† Digest Ease - Mastic Gum/DGL - Cinnamon flavored chewable tablet containing DGL (deglycyrrhizinated licorice root and rhizome extract) and mastic gum to support healthy digestion and gastrointestinal function.† This product may help alleviate gastrointestinal discomfort associated with occasional indigestion.† GI Support - Provides extensive support for the entire GI tract by addressing energy requirements of intestinal mucosa, structural composition of intestinal and colonic cells, microorganism balance, and production of protective intestinal mucus secretions.† You can also listen to Acid, Indigestion, and Bloating on our YouTube channel here.
Broad Spectrum Digestive Enzymes Children on the autism spectrum have difficulty digesting their food properly. This means they do not absorb the nutrients from the foods they eat. This starves their brain of what it needs to function properly. Broad spectrum enzymes assist in the digestion of many foods including protein, carbohydrates, fats, and fiber. Enzymes are naturally produced by the body unless the GI tract is not working properly. If so, digestion and absorption of nutrients and many other factors are effected. Enzymes can be very helpful when taken just before or with meals to help break down food particles, proteins, carbohydrates, and fats. The enzyme known as DPPIV helps break down the large proteins in wheat known as gluten, and casein in dairy. Enzymes for Therapeutic use When enzymes are taken away from food they can be helpful as little garbage collectors in the sense of cleaning up the toxic debris from various viral and bacterial issues. Benefits Beyond Digestion Enzymes can be extremely helpful with the sensitive digestion needs of those with autism, ADHD, allergies, and more. By improving digestion there can be a reduction in inflammation in the GI tract, therefore, better overall health. Keeping the gut healthy is crucial. The gut has receptors that make neurotransmitters for the brain such as serotonin which effects mood, appetite, and sleep, and GABA which acts to calm nerve function. Enzymes also act as little garbage collectors cleaning up toxic debris . From using enzymes parents report better concentration, increased language abilities, improved digestion, and behavior. Help with positive gut bacteria and phenols There are beneficial microorganisms in the gut that are built from fiber foods such as vegetables. If the GI tract is compromised and weak it can have trouble digesting fiber. Additionally, Phenols are a compound found in many healthy foods including vegetables and dark colored fruit. These are healthy foods but our kids may be sensitive to them. One enzyme formula that can be helpful with both fiber digestion and phenols is No-Phenol from Houston-Enzymes. They come in capsules and chewable form. Some Common Enzymes are: • Dipeptidyl peptidase IV (DPP-IV) breaks down casomorphin (from casein) and gluteomorphins (from gluten) • Proteases break down proteins • Lactase breaks down lactose (found in dairy) • Amylase for starch (carbohydrate) digestion • Alpha-galactosidase breaks down beans and other fiber-rich foods • Xylanase helps digest fruits and vegetables (phenolic foods) • Beta-glucanase for fiber-rich vegetables and grains • Lipase breaks down lipids or fats • Bromelain and papain are enzymes derived from pineapple. They break down proteins. Note: Some people exhibit sensitivities to fruit or citrus, so watch for signs of this from your child. Cellulase may interfere with some time-released, cellulose-based medications. Ask your doctor or check your labels for hydroxypropyl cellulose, or hypromellose. Some products come as “cellulose-free”. Quality Products Broad spectrum digestive enzymes are taken just prior to eating a meal for their assistance in digestion. This helps the body absorb nutrients for better health and well being. There are several great products available such as Trienza by Houston-Enzymes. This formula has the added benefit of DPP-IV, a specific enzyme that breaks down the larger proteins in dairy and wheat products that can injure the gut lining and create toxins in the blood which make their way to the brain. This often triggers an allergic response to these foods. Trienza also comes in a chewable form. The size of the meal often determines the dosage. Start slowly with half the recommended dosage and work your way up to the full amount over a 12-14 day period. The beauty of broad spectrum enzymes is that they assist with so many different types of foods. We do not always know exactly what disturbs our digestion. This way we cover a multitude of possibilities with one product. Radio Show interview Please listen to my radio show interview with Dr. Devon Houston of Houston-Enzymes. It is show #44. You can find it here. About Dr. Houston Devin Houston Ph.D. Incorporator and CEO of Houston Nutraceuticals Dr. Houston obtained a B.A. degree in Biology from Hendrix College in 1979. He then was awarded a B.S. degree in Medical Science in 1980 and a Ph.D. in Biochemistry from the University of South Alabama College of Medicine in 1987. Dr. Houston’s graduate work focused on how the aging process affected certain enzyme systems. Click Here for more details.
Digestive Boost is a unique combination of specially selected enzymes and supportive ingredients to help you breakdown your food and enhance absorption of key nutrients that we need from our diet. Our doctor-selected enzyme blend in Digestive Boost is uniquely designed to help with gluten and dairy which many find most difficult to break down effectively and efficiently. It is recommended for those with digestive challenges, who take antacids or reflux medication regularly and for older clients who need some extra help as we age. There are specific enzymes like the well-known DPP IV included along with other key elements to aid in breaking down gluten, proteins, fats and dairy as well as general digestion. As always, no fillers or wasted space in the capsule – we have maximized the contents and value for you! .fusion-button.button-145 {border-radius:25px;}Order Now.fusion-image-frame-bottomshadow.image-frame-shadow-271{display:inline-block}.element-bottomshadow.imageframe-271:before, .element-bottomshadow.imageframe-271:after{-webkit-box-shadow: 0 17px 10px rgba(0,0,0,0.4);box-shadow: 0 17px 10px rgba(0,0,0,0.4);}BYWG's Product of the Month We’ve been a huge fan of Butcher Box for years. In fact you can listen to me interview the CEO Mike Salguero in the podcast archives. Personally I look forward to my ‘”box” of grass fed meats every month. I get the beef – pork – chicken combo box and regularly take advantage of their specials. From June 1st to June 11th using the code https://www.butcherbox.com/beyondyourwildestgenes/ for new customers you are eligible for FREE Shipping, FREE Bacon, and $20 off your first box. From June 12th till July 7th Butcher Box has created a special offer for our listeners who are new Butcher Box customers - FREE BACON FOR LIFE! I love grass fed beef, organic chicken, wild caught fish, and heritage pork – especially in the form of BACON! BYWG's Book of the Month: Chasing Cupcakes How One Broke, Fat Girl transformed Her Life (and How You Can, Too) by Elizabeth Benton Great read folks! You can listen to me interview Elizabeth on the BYWG Podcast.
Episode 5 - GLP 1 And DPP IV (Guest: Dr. Diana McNeill & Dr. David D'Alessio) by DukeWELL
Anjani Shah, Ph.D., Conference Director, Cambridge Healthtech Institute, interviews Dr. Nhut Diep of Forest Laboratories on February 19, 2014. Dr. Diep will be speaking during the 7th Annual 'Efficient Process Chemistry' conference taking place May 22-23, 2014 as part of CHI's World Pharma Congress May 21-23 in Boston, MA. Efforts to identify a scalable process for preparing DPP-IV inhibitor compounds (diabetes therapeutic) led to the discovery of several useful transformations, including the asymmetric lithiation-boronation of the Boc-pyrrolidine that provided a single compound; the development of a streamline-telescope coupling reaction and workup which led to a robust crystallization/purification method.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 01/07
Orally and intravenously administered glucose yields comparable levels of glucose in plasma but different responses of insulin-release. Specialised mucosa cells react to glucose contents in chyme with release of glucagon-like peptide-1 (GLP-1) into the portal bloodstream, a peptide hormone, that makes beta-cells more sensitive to the subsequent glucose stimulus and thereby enhances the insulin-release exclusively under increased blood glucose levels without causing the insulin-release directly. The capacity of this entero-insular axis is limited primarily by the endogenous enzyme dipeptidyl peptidase IV (DPP-IV). Prevailingly the most progressive approach to therapy of non-insulin-dependent diabetes mellitus (NIDDM) in human medicine is targeted on the inhibition of DPP-IV, in order to raise GLP-1 concentration in plasma and to increase consequently the insulin-release in dependence on elevated blood glucose levels. In the limelight of discussion are the advantages of certain avoidance of insulin-caused hypoglycaemia on the one hand and the possibility of oral administration of the antienzyme on the other hand. In contrast to the condition in dogs, where the disease manifests almost exclusively in the form of secondary (insulin-dependent) diabetes mellitus, the type 2 (NIDDM) predominates in humans as well as in cats, whence it comes that the employment of oral antidiabetics in the latter species is quite promising, as the experience with the sulfonyl urea derivative glipizide has shown. As however the residual capacity of beta-cells of feline diabetics with regard to the release of endogenous insulin is subject to considerable variation, the risk of inducing hypoglycaemia is given by use of both insulin and sulfonyl urea derivatives, whereas this threat is circumvented by use of DPP-IV-inhibitors. In the present thesis the effect of DPP-IV inhibition on the elimination kinetics of GLP-1 is described by means of systematically combined infusion of the enzyme’s substrate (GLP-1) and its antienzyme in the rat model. The maximum effective dose of DPP-IV inhibitor is determined and the portion of hepatic clearance and whole blood clearance of total elimination of GLP-1 without concurrent DPP-IV inhibition is quantified approximately by means of isolated perfused rat livers and in-vitro-experiments. Finally the dependence of results on the respective experimental design is demonstrated. The total clearance of GLP-1 as substrate of DPP-IV without concurrent inhibition amounts to at least 57 ± 17 (mL/min)/kg and under influence of the DPP-IV-inhibitor to at least 22 ± 2 (mL/min)/kg. The value of clearance is highly dependent on the respective substrate concentration in plasma, so that the values range from 139 ± 57 (mL/min)/kg to 73 ± 15 (mL/min)/kg within the bounds of physiological GLP-1 concentrations in plasma. The maximum increase of GLP-1 levels in plasma (factor 3.4) on average of all GLP-1 infusion rates was attained by a DPP-IV inhibitor concentration in plasma of 0.4 µmol/L. The liver as central detoxication-organ figures out at 57 % (34/60) of total clearance, the soluble DPP-IV fraction in plasma however accounts for only about 1 % (0.7/60) of total clearance. The relatively low hepatic extraction ratio of 30 ± 11 % reversely allows seven out of ten GLP-1 molecules to enter the systemic circulation in spite of the first-pass-effect and thereby to reach possibly the receptors on the beta-cells (70 % bioavailability). The half-life of GLP-1 (7-36 amide) in the isolated perfused rat liver amounts to 5.0 ± 1.3 minutes, hereby differing statistically not significantly (p = 0.114) from the half-life of GLP-1 (7-37) with 6.1 ± 1.6 minutes.