Podcasts about Journal club

Stress is often associated with obvious challenges such as heat or transportation, but Dr. Baumgard explains that many stressors trigger similar biological responses. Understanding these shared pathways provides important insight into how stress influences animal health, nutrient utilization, immune function, and ultimately dairy cow performance. (00:00 – 05:16)  The panel examines common stressors encountered in dairy systems, including heat stress, weaning, overcrowding, feed interruptions, dehorning, environmental noise, facility design challenges, and routine management disruptions. The speakers emphasize that stress is not always obvious. In addition, they note that multiple seemingly minor challenges can collectively impact health, welfare, and productivity. (05:17 – 08:29)  A major portion of the discussion focuses on what happens inside the animal during periods of stress. Dr. Baumgard explains how activation of the hypothalamic-pituitary-adrenal (HPA) axis triggers a cascade involving mast cell signaling, reduced mucus production, and increased intestinal permeability. These physiological changes can create conditions that favor pathogen growth. In addition, they can increase inflammation, and reduce productive efficiency. (08:30 – 11:12)  The conversation then turns to gastrointestinal barrier dysfunction, often referred to as "leaky gut." The panel discusses the gut's role as a critical defense system and explains why maintaining intestinal integrity is essential for nutrient absorption, immune regulation, and overall animal health. When stress compromises this barrier, animals become more susceptible to inflammation and disease challenges. (11:13 – 13:26)  While nutrition can play a supportive role, Dr. Baumgard argues that reducing stress through management practices often delivers the greatest return on investment. Preventing stress before it occurs is frequently more effective than attempting to correct physiological disruptions after they have already begun. (13:27 – 14:18)  The speakers also explore the concept of adaptation and stacked stressors, particularly during the transition period. Transition cows frequently encounter multiple challenges simultaneously. Moreover, the cumulative effects of several stressors may overwhelm an animal's ability to adapt. This helps explain why health disorders and performance declines often emerge during critical production stages. (14:19 – 17:28) Heat stress receives special attention as one of the most economically significant stressors affecting dairy cattle worldwide. Dr. Baumgard details how heat stress redistributes blood flow away from the gastrointestinal tract, leading to gut hypoxia and impaired intestinal function. The discussion also examines why cows naturally reduce feed intake during hot conditions. In addition, it explains why cooling and management interventions often outperform nutritional strategies alone. (17:29 – 27:04) The panel then reviews nutritional approaches that may help support animals during periods of stress. While antioxidant responses have been inconsistent across research studies, Dr. Baumgard highlights evidence suggesting that highly bioavailable zinc sources can consistently support intestinal integrity. These zinc sources can also improve resilience during stressful events. (27:05 – 32:22) Another key topic is immune activation and nutrient partitioning. The speakers explain that activated immune systems become major consumers of glucose and amino acids, diverting nutrients away from productive functions such as milk synthesis. This shift helps explain why production losses during stressful periods often exceed what would be expected from reduced feed intake alone. (32:23 – 37:13)  The episode concludes with a discussion on inflammation, endotoxin handling, mineral metabolism, hypocalcemia, and future research priorities. The panel examines how inflammation influences calcium and trace mineral dynamics during the transition period. Furthermore, they discuss the ongoing challenge of identifying practical solutions to stress-induced gut barrier dysfunction. (37:14 – 45:38) Understanding stress physiology requires looking beyond individual stress events and recognizing the interconnected biological systems that influence animal performance. Whether stress originates from environmental conditions, management practices, or physiological demands, many stressors converge on common pathways that affect gut health, immune function, nutrient utilization, and productivity. This episode provides valuable insight into the mechanisms behind those responses. Moreover, it highlights why effective stress management remains one of the most powerful tools for improving dairy cattle health and performance. Please subscribe and share with your industry friends. This helps increase awareness of topics like the impact of excess liver copper concentrations. Invite more people to join us at the Real Science Exchange virtual pub table. Please be sure to register for our upcoming Real Science Lecture Series. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription. Then, email a picture to anh.marketing@balchem.com. Include your size and mailing address.

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Drs. Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Dr. Vikram Mookerjee, discuss the following articles from the August 2026 issue:   "Logistical, Ethical, and Technical Considerations in the World's First Face and Whole Eye Transplantation" by Chinta, Tran, Shah, et al.   Read the article for FREE: https://bit.ly/1st_Face_and_Whole_Eye_Transplant   Explore the articles discussed in this podcast as well as free related content: https://bit.ly/JCAug26Collection   Dr. Vikram Mookerjee is a Yale-trained, fellowship-trained plastic surgeon practicing in Beverly Hills and Rancho Mirage, California. He specializes in aesthetic and reconstructive surgery of the face, breast, and body, with a particular focus on facial rejuvenation and facial reconstruction.   Originally from Pittsburgh, Dr. Mookerjee completed his undergraduate and medical education through Boston University's accelerated seven-year B.A./M.D. program before completing plastic surgery residency at Yale University and fellowship training with The Aesthetic Surgery Fellowship of Los Angeles. During his training, he received the Young Investigator Award for his research on wound healing mechanisms, as well as the Yale Plastic Surgery Scholastic Award for achieving the highest In-Service Examination score in his residency program.   Dr. Mookerjee serves as a Next Generation Editor on the Editorial Board of the Aesthetic Surgery Journal and has authored numerous peer-reviewed publications in aesthetic and reconstructive plastic surgery.   The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Chuck and Chris review 6 recent Journal of Hand Surgery articles with a variety of topics.  Tune in and see below.1) Arends GR, van Kooij YE, Stern BZ, Hovius SER, Wouters RM; Hand-Wrist Study Group; de Ridder WA. Understanding Why Certain Patients With Hand and Wrist Conditions Are Dissatisfied Despite Achieving Their Expressed Personal Improvement Goals Anchored at Satisfaction: A Qualitative Study. J Hand Surg Am. 2026 Jun;51(6):687-697. doi: 10.1016/j.jhsa.2025.12.009. Epub 2026 Jan 29. PMID: 41609542.2) Lee SH, Kim MB, Lee YH. Surgical Management of Delayed Mallet Finger Fractures Using Combined Two-Extension Block Kirschner Wire and Dorsal Counterforce Techniques. J Hand Surg Am. 2026 May;51(5):555-563. doi: 10.1016/j.jhsa.2025.12.019. Epub 2026 Jan 29. PMID: 41609545.3) Lunasin RM, Capell W, Kaufman KR, Shin AY. Rethinking Muscle Testing: Dynamic EMG Studies of Elbow Positioning as a Differentiator of Pronator Teres and Quadratus Functions. J Hand Surg Am. 2026 Apr;51(4):437.e1-437.e8. doi: 10.1016/j.jhsa.2025.09.013. Epub 2025 Oct 29. PMID: 41159989.4) Morisaki S, Yoshii K, Tsuchida S, Oda R, Takahashi K. Comparison of Manual Tie and Knotless Suture Anchor Techniques in Arthroscopic Transosseous Foveal Repair of the Triangular Fibrocartilage Complex. J Hand Surg Am. 2026 May;51(5):503-510. doi: 10.1016/j.jhsa.2026.01.021. Epub 2026 Mar 4. PMID: 41778936.5) Mwangi J, Henriquez AR, Varney CR, Yu R, Kim JK, Baker RL Jr, Pidgeon T, Hammert WC. Suture-Button Suspensionplasty Does Not Provide a Sustained Functional Advantage Over Ligament Reconstruction and Tendon Interposition for Thumb Carpometacarpal Arthritis. J Hand Surg Am. 2026 Jun;51(6):623-630. doi: 10.1016/j.jhsa.2026.02.019. Epub 2026 Apr 3. PMID: 41934451.6) Surke C, Del Rosario PA, Huntington LS, Ek ETH, Tham SK, Ackland D. Fracture Fixation in an Unstable Scaphoid Fracture Model: A Biomechanical Comparison of Double Screw Osteosynthesis With Two Common Bone Graft and Fixation Techniques. J Hand Surg Am. 2026 Apr;51(4):391.e1-391.e8. doi: 10.1016/j.jhsa.2025.09.007. Epub 2025 Oct 25. PMID: 41137815.See www.practicelink.com/theupperhand for more information from our partner on job search and career opportunities.The Upper Hand Podcast is sponsored by Checkpoint Surgical, a provider of innovative solutions for peripheral serve surgery. To learn more, visit https://checkpointsurgical.com/.As always, thanks to @iampetermartin for the amazing introduction and concluding music.For additional links, the catalog.  Please see https://www.ortho.wustl.edu/content/Podcast-Listings/8280/The-Upper-Hand-Podcast.aspx

Send us Fan MailThe full week of Journal Club in one place. Monday, the PLaNT trial of prophylactic CPAP for late preterm infants born by cesarean, with senior author Dr. Edgardo Szyld. Tuesday, whether parental holding during therapeutic hypothermia changes feeding and length of stay. Wednesday, the Connection Study, the first live biotherapeutic product tested under an IND, and what it means for probiotics returning to the NICU. Thursday, a handheld light probe that reads bowel through the skin to catch NEC before the X-ray does. Friday, Dr. Dinushan Kaluarachchi on the respiratory severity score and what its trajectory tells us.----First-in-human pilot study of broadband optical spectroscopy (BOS) as noninvasive surveillance for necrotizing enterocolitis (NEC). Dodd AC, Lehane AJ, Lee A, Hurlock A, Su Y, Ilahi I, Lautz TB, Backman V, Goldstein SD.J Pediatr Surg. 2026 May;61(5):162978. doi: 10.1016/j.jpedsurg.2026.162978. Epub 2026 Feb 3.PMID: 41643767Association of parental holding during therapeutic hypothermia and NICU outcomes for infants with hypoxic-ischemic encephalopathy. Nguyen TT, Glass HC, Chan N, Taketa E, Pineda R, Cornet MC, Miller MJ.J Perinatol. 2026 Jun 22. doi: 10.1038/s41372-026-02753-3. Online ahead of print.PMID: 42332041Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study. Neu J, Del Moral T, Guthrie SO, Hudak ML, Indrio F, Kim JH, Kronström A, Martin CR, Modi N, Rastad J, Schnitzer TJ, Singh R, Strömberg S, Szajewska H, Thuresson M, Caplan M.Pediatr Res. 2026 Feb 20. doi: 10.1038/s41390-026-04826-7. Online ahead of print.PMID: 41721054Prophylactic CPAP at Cesarean Birth in Late-Preterm Newborns: A Multicenter RCT. Shah BA, DeShea L, Schmölzer GM, Josephsen JB, Fabres J, Wetzel EA, Rykovich H, Thomas A, Law B, Garrido C, Szyld E.Pediatrics. 2026 Aug 1;158(2):e2025070998. doi: 10.1542/peds.2025-070998.PMID: 42457181 Clinical Trial.Association Between Delivery Room Continuous Positive Airway Pressure and Neonatal Outcomes in Late Preterm and Term Infants: A Systematic Review and Meta-Analysis. Chin Y, Hill M, Sett A, Thomas N, Razak A.J Paediatr Child Health. 2026 Jul 28. doi: 10.1111/jpc.70516. Online ahead of print.PMID: 42517258 Review.Bronchopulmonary Dysplasia Definition Based on Respiratory Severity Score. Kaluarachchi DC, Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM.Pediatr Pulmonol. 2026 Jul;61(7):e71750. doi: 10.1002/ppul.71750.PMID: 42478108 Free PMC article. No abstract available.Respiratory severity score patterns by birth gestational age among a cohort of extremely preterm infants. Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM, Keller RL, Kaluarachchi DC.J Perinatol. 2026 Jun 29. doi: 10.1038/s41372-026-02778-8. Online ahead of print.PMID: 42374145 No abstract available.Respiratory severity score as a predictor for need for tracheostomy in infants with severe bronchopulmonary dysplasia. Kaluarachchi NM, Afah Annah S, Lasarev MR, Peebles PJ, Kaluarachchi DC.J Perinatol. 2026 Jun 25. doi: 10.1038/s41372-026-02720-y. Online ahead of print.PMID: 42350618 No abstract available.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailThe respiratory severity score is one multiplication most of us already do in our heads, mean airway pressure times FiO2. This week Dr. Dinushan Kaluarachchi joins Journal Club to walk through three papers built on it, RSS trajectories across gestational age in the PROP cohort, an RSS based grading of BPD at 36 weeks, and RSS after 40 weeks as a predictor of tracheostomy. He also talks about writing that last paper with his son, a high school junior, and why a brief communication is a realistic on-ramp for students. Plus a preview of two upcoming trials, including surfactant given through a supraglottic airway.https://www.nature.com/collections/ejaffajdhi----Bronchopulmonary Dysplasia Definition Based on Respiratory Severity Score. Kaluarachchi DC, Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM.Pediatr Pulmonol. 2026 Jul;61(7):e71750. doi: 10.1002/ppul.71750.PMID: 42478108 Free PMC article. No abstract available.Respiratory severity score patterns by birth gestational age among a cohort of extremely preterm infants. Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM, Keller RL, Kaluarachchi DC.J Perinatol. 2026 Jun 29. doi: 10.1038/s41372-026-02778-8. Online ahead of print.PMID: 42374145 No abstract available.Respiratory severity score as a predictor for need for tracheostomy in infants with severe bronchopulmonary dysplasia. Kaluarachchi NM, Afah Annah S, Lasarev MR, Peebles PJ, Kaluarachchi DC.J Perinatol. 2026 Jun 25. doi: 10.1038/s41372-026-02720-y. Online ahead of print.PMID: 42350618 No abstract available.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailNEC still tends to announce itself on an X-ray, usually later than we want. This week Daphna reviews the first-in-human study of broadband optical spectroscopy, a handheld transcutaneous probe out of Lurie Children's that reads reflected light from 350 to 2500 nanometers to look at bowel beneath the skin. Just under 100 preterm infants, more than 11,000 scans, and a machine learning model that separated NEC from non-NEC scans with 100% sensitivity and a 100% negative predictive value, though the positive predictive value sat at 24%. Ben and Daphna work through what the curves actually show and what would have to come next.----First-in-human pilot study of broadband optical spectroscopy (BOS) as noninvasive surveillance for necrotizing enterocolitis (NEC). Dodd AC, Lehane AJ, Lee A, Hurlock A, Su Y, Ilahi I, Lautz TB, Backman V, Goldstein SD.J Pediatr Surg. 2026 May;61(5):162978. doi: 10.1016/j.jpedsurg.2026.162978. Epub 2026 Feb 3.PMID: 41643767Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailProbiotics left US NICUs after the FDA reclassified them, and NEC rates went up. This week Ben reviews the Connection Study, a 2,158 infant phase 3 trial of IBP-9414, a live biotherapeutic product containing Limosilactobacillus reuteri, run under an IND with the regulatory rigor probiotics never had. Neither primary endpoint reached significance, but all cause mortality fell 27%, and surgically confirmed NEC favored treatment after 14 days of dosing. The discussion may be the real story, including a kappa of 0.36 between radiologists reading the same NEC films. Ben and Daphna talk through what a regulated probiotic would mean for the babies waiting now.----Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study. Neu J, Del Moral T, Guthrie SO, Hudak ML, Indrio F, Kim JH, Kronström A, Martin CR, Modi N, Rastad J, Schnitzer TJ, Singh R, Strömberg S, Szajewska H, Thuresson M, Caplan M.Pediatr Res. 2026 Feb 20. doi: 10.1038/s41390-026-04826-7. Online ahead of print.PMID: 41721054Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Drs. Akshay Thomas and Sarwar Zahid join for a journal club discussion of three recent articles in the ophthalmology literature. Retinal Laser Prophylaxis for Lattice Degeneration (https://www.ophthalmologyretina.org/article/S2468-6530(26)00308-8/abstract) Anti-VEGF Access Medicare Advantage versus Fee-for-service (https://www.aaojournal.org/article/S0161-6420(26)00453-7/abstract) Conversion to Wet Macular Degeneration after Cataract Surgery (https://www.aaojournal.org/article/S0161-6420(26)00420-3/abstract)

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Drs. Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Dr. Vikram Mookerjee, discuss the following articles from the August 2026 issue:   "The Face Lift: An Algorithm for Producing Consistently Superior Results" by Sundine.   Read the article for FREE: https://bit.ly/facelift-algorithm   Explore the articles discussed in this podcast as well as free related content: https://bit.ly/JCAug26Collection   Dr. Vikram Mookerjee is a Yale-trained, fellowship-trained plastic surgeon practicing in Beverly Hills and Rancho Mirage, California. He specializes in aesthetic and reconstructive surgery of the face, breast, and body, with a particular focus on facial rejuvenation and facial reconstruction.   Originally from Pittsburgh, Dr. Mookerjee completed his undergraduate and medical education through Boston University's accelerated seven-year B.A./M.D. program before completing plastic surgery residency at Yale University and fellowship training with The Aesthetic Surgery Fellowship of Los Angeles. During his training, he received the Young Investigator Award for his research on wound healing mechanisms, as well as the Yale Plastic Surgery Scholastic Award for achieving the highest In-Service Examination score in his residency program.   Dr. Mookerjee serves as a Next Generation Editor on the Editorial Board of the Aesthetic Surgery Journal and has authored numerous peer-reviewed publications in aesthetic and reconstructive plastic surgery.   The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Send us Fan MailParents of babies undergoing therapeutic hypothermia often wait days before they can hold their child, and many never get the chance during cooling at all. This week on Journal Club, Daphna reviews a new Journal of Perinatology retrospective cohort from two level IV NICUs, 379 infants with HIE, where 28% were held during cooling. Held infants reached full oral feeds sooner, were more likely to go home on breast milk, and had shorter stays, but they were also less sick to begin with. Ben pushes on confounding, on the exclusion of infants who died, and on what equipment would make holding routine.----Association of parental holding during therapeutic hypothermia and NICU outcomes for infants with hypoxic-ischemic encephalopathy. Nguyen TT, Glass HC, Chan N, Taketa E, Pineda R, Cornet MC, Miller MJ.J Perinatol. 2026 Jun 22. doi: 10.1038/s41372-026-02753-3. Online ahead of print.PMID: 42332041Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailLate preterm babies born by cesarean fill our NICUs, and most of them are there for respiratory distress that resolves in a day or two. Could 20 minutes of CPAP in the operating room keep them out? This week on Journal Club, Ben and Daphna break down the PLaNT trial, a five center randomized pilot of prophylactic CPAP at 5 to 6 cm of water in spontaneously breathing infants born at 34 to 36 weeks by cesarean. They then sit down with senior author Dr. Edgardo Szyld to talk pneumothorax risk, the 35 to 36 week subgroup, consenting families, and what PLaNT 2 must prove.----Prophylactic CPAP at Cesarean Birth in Late-Preterm Newborns: A Multicenter RCT. Shah BA, DeShea L, Schmölzer GM, Josephsen JB, Fabres J, Wetzel EA, Rykovich H, Thomas A, Law B, Garrido C, Szyld E.Pediatrics. 2026 Aug 1;158(2):e2025070998. doi: 10.1542/peds.2025-070998.PMID: 42457181 Clinical Trial.Association Between Delivery Room Continuous Positive Airway Pressure and Neonatal Outcomes in Late Preterm and Term Infants: A Systematic Review and Meta-Analysis. Chin Y, Hill M, Sett A, Thomas N, Razak A.J Paediatr Child Health. 2026 Jul 28. doi: 10.1111/jpc.70516. Online ahead of print.PMID: 42517258 Review.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Join the APN crew for a monthly discussion of recent news articles. This month we look into two very different questions about archaeology and how we interpret the past. First, we dig into the growing role of AI and large language models in archaeological research, discussing hallucinations, data ownership, consent, open access, and why critical thinking is more important than ever. Then, we examine the case of a man who survived a severe facial injury roughly 100,000 years ago—and ask whether the more interesting story is really ancient violence, or the care and community that allowed him to survive. Links Archaeology in the AI Era: Demystifying powerful and problematic systems shaping the future of the past Roughly 100,000 Years Ago, This Man Got Stabbed in the Face—and Survived. He's Likely One of the First Known Victims of an Attack With a Sharp Weapon Contact Chris Webster chris@archaeologypodcastnetwork.com Rachel Roden rachel@unraveleddesigns.com RachelUnraveled (Instagram) ArchPodNet APN Website: https://www.archpodnet.com APN Discord: https://discord.com/invite/CWBhb2T2ed APN on Facebook: https://www.facebook.com/archpodnet APN on Twitter: https://www.twitter.com/archpodnet APN on Instagram: https://www.instagram.com/archpodnet APN Shop Affiliates Motion Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Join the APN crew for a monthly discussion of recent news articles. This month we look into two very different questions about archaeology and how we interpret the past. First, we dig into the growing role of AI and large language models in archaeological research, discussing hallucinations, data ownership, consent, open access, and why critical thinking is more important than ever. Then, we examine the case of a man who survived a severe facial injury roughly 100,000 years ago—and ask whether the more interesting story is really ancient violence, or the care and community that allowed him to survive. Links Archaeology in the AI Era: Demystifying powerful and problematic systems shaping the future of the past Roughly 100,000 Years Ago, This Man Got Stabbed in the Face—and Survived. He's Likely One of the First Known Victims of an Attack With a Sharp Weapon Contact Chris Webster chris@archaeologypodcastnetwork.com Rachel Roden rachel@unraveleddesigns.com RachelUnraveled (Instagram) ArchPodNet APN Website: https://www.archpodnet.com APN Discord: https://discord.com/invite/CWBhb2T2ed APN on Facebook: https://www.facebook.com/archpodnet APN on Twitter: https://www.twitter.com/archpodnet APN on Instagram: https://www.instagram.com/archpodnet APN Shop Affiliates Motion Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

AMEE is the International Association for Health Professions Education. This year the annual conference is on in Vienna, Austria from August 22 – 26. Each year – the AMEE Simulation Committee has a session in which 4 nominated papers are presented and judged.  Leizl Nayahangan and Ross Scalese are on that committee and spoke to us about the event, the process and the papers.  If you want to go to AMEE 2026… https://amee.org/events/amee-2026/.  The Simulation Committee Journal club is on Tuesday 26th 0900. Turn up early !  Our guests  Ross Scalese is a practicing General Internal Medicine physician; Professor of Medicine and Medical Education at the University of Miami (UM) Miller School of Medicine in Florida, USA; and Director of Educational Technology Development at UM's Gordon Center for Simulation and Innovation in Medical Education.  Leizl (LIEzl) Nayahangan is chair of the AMEE Simulation Committee, and a research scientist at the Copenhagen Academy for Medical Education and Simulation (CAMES) in Copenhagen, Denmark. She is currently completing her PhD, focusing on the implementation of simulation-based education.    The finalists !    Schram A, et al. Exploring the relationship between simulation-based team training and sick leave among healthcare professionals: a cohort study across multiple hospital sites. BMJ Open. 2023;13:e076163.   Petrosoniak A, et al. Moving beyond projects: a logic model evaluation of an established translational simulation program. Adv Simul (Lond). 2026;11:39. doi:10.1186/s41077-026-00434-x.   Weller JM, et al. Effects of a national team training intervention for operating theatre teams on patient and staff outcomes: a stepped-wedge cluster-randomised trial and mixed-methods study. Br J Anaesth. 2026;136(4):1361-1370.   Tallentire VR, McColgan-Smith S, Stewart F, McIntyre S, Smith SE. The delicate dance of debriefing: exploring how behavioural marker systems influence the socio-emotional dynamics of simulation practice. Adv Simul (Lond). 2026;11:20.     Congratulations to all the finalists and – if you're not attending – we'll let you know the winner next month on Simulcast 

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Drs. Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Dr. Vikram Mookerjee, discuss the following articles from the August 2026 issue:   "Extended Gliding Brow Lift: An Effective Solution for Brow and Periorbital Rejuvenation" by Sozer, Ersan, Kachare, et al.   Read the article for FREE: https://bit.ly/extended-gliding-brow-lift   Explore the articles discussed in this podcast as well as free related content: https://bit.ly/JCAug26Collection   Dr. Vikram Mookerjee is a Yale-trained, fellowship-trained plastic surgeon practicing in Beverly Hills and Rancho Mirage, California. He specializes in aesthetic and reconstructive surgery of the face, breast, and body, with a particular focus on facial rejuvenation and facial reconstruction.   Originally from Pittsburgh, Dr. Mookerjee completed his undergraduate and medical education through Boston University's accelerated seven-year B.A./M.D. program before completing plastic surgery residency at Yale University and fellowship training with The Aesthetic Surgery Fellowship of Los Angeles. During his training, he received the Young Investigator Award for his research on wound healing mechanisms, as well as the Yale Plastic Surgery Scholastic Award for achieving the highest In-Service Examination score in his residency program.   Dr. Mookerjee serves as a Next Generation Editor on the Editorial Board of the Aesthetic Surgery Journal and has authored numerous peer-reviewed publications in aesthetic and reconstructive plastic surgery.   The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

In Part 2, we transitioned to a journal club featuring two impactful recent publications on astigmatism management. Dr. Sella reviews a randomized clinical trial comparing femtosecond laser arcuate keratotomy (FLAK) versus toric intraocular lens implantation for the correction of corneal astigmatism during cataract surgery, followed by a discussion of toric intraocular lens calculations in eyes with corneal ectasia, highlighting the unique challenges of achieving accurate refractive outcomes in patients with irregular corneas. Together, both episodes combine expert perspective with the latest clinical evidence, offering practical insights into contemporary cataract and refractive surgery. Whether you are a resident, comprehensive ophthalmologist, anterior segment surgeon, or simply interested in advances in ophthalmology, we hope you enjoy both parts of this special series. Subscribe to the podcast:  https://MayoClinicOphthalmology.podbean.com   Follow and reach out to us on X and IG: @mayocliniceye

In this Journal Club episode Dr Paula Redmond joins me to discuss a journal article about using knitting in a center for drug and alcohol rehabilitation. This is a narrative of a knitting group within a rehab center for women living with addiction.The paper is here:Duffy, K. (2007). Knitting through recovery one stitch at a time: Knitting as an experiential teaching method for affect management in group therapy. Journal of Groups in Addiction & Recovery, 2(1), 67–83. https://doi.org/10.1300/J384v02n01_04 [1, 2]Unfortunately the full text is not available for free, but anyone in the UK can access it via a local library.-------------

Send us Fan MailNeste episódio, comentamos quatro artigos recentes que atravessam a linha de frente da neonatologia — da sala de parto ao acompanhamento de longo prazo.Começamos pelo estudo PLaNT (Pediatrics), um ensaio clínico randomizado que testou o CPAP profilático em recém-nascidos pré-termo tardios nascidos de cesárea, avaliando segurança, viabilidade e impacto na necessidade de suporte respiratório. https://pubmed.ncbi.nlm.nih.gov/42457181/Em seguida, um estudo sueco (Journal of Perinatology) traz dados inéditos sobre estabilidade térmica durante o cuidado pele a pele em prematuros extremos, de 22 a 25 semanas — território pouco explorado até aqui. https://www.nature.com/articles/s41372-026-02829-0No terceiro bloco, discutimos os resultados do ensaio PAEAN (JAMA Pediatrics), que testou a eritropoetina como terapia adjuvante à hipotermia na encefalopatia hipóxico-isquêmica neonatal. http://10.1001/jamapediatrics.2026.3082E fechamos com um estudo canadense (Journal of Perinatology) sobre a associação entre número de tentativas de laringoscopia nos primeiros dias de vida e hemorragia intraventricular grave em prematuros extremos. https://www.nature.com/articles/s41372-026-02811-wCiência atual, leitura crítica e implicações práticas para quem cuida de recém-nascidos — sempre com um olhar para a nossa realidade assistencial.A Incubadora é o Podcast oficila do CINEO 2026, que acontece em Brasília, DF nos dias 26, 27 e 28 de Novembro. Esperamos vocês? O link para inscrições no CINEO 2026 você encontra aqui: https://cineo.com.br/ Não esqueça: você  pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação.Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.orgEvidência, cuidado e contexto brasileiro - esse é o nosso roteiro.

Send us Fan MailWhich babies with critical congenital heart disease face the highest risk of brain injury, and does earlier surgery actually help? Why is infant CHD mortality climbing again after years of decline, and who's most affected? Can a mother's cardiovascular status in preeclampsia predict her newborn's circulatory transition? This week's Journal Club brings together five conversations on CHD, maternal-fetal physiology, and vaccine policy. Nim and Adrianne cover a meta-analysis on brain injury in critical CHD, a 25-year national mortality study, a pilot study on preeclampsia and neonatal cardiac output, and a look at RV diastolic function after CHD intervention. Ben and Eli close with Neo News on a controversial hepatitis B vaccine trial in Guinea-Bissau.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailIn this prospective study, Adrianne and Nim dig into an area with almost no normative pediatric data: right ventricular diastolic function. Comparing 57 infants with RV pressure overload after intervention for pulmonic stenosis or tetralogy of Fallot to 134 healthy controls, the authors found a consistent pattern, reduced beat-to-beat variability, a higher atrial contribution to filling, and an E/A ratio inversion that was nearly universal in the CHD group versus about half of controls. It's one of the first real attempts to define what a right-sided diastolic pattern actually looks like in this population. But without a comparison against cardiac catheterization, the hosts agree the findings are hypothesis-generating at best, a starting point for a multi-parametric approach, not a reason to skip an invasive workup.----Echocardiographic Markers of Right Ventricle Diastolic Dysfunction in Neonates and Infants with Congenital Heart Disease. Cantinotti M, Capponi G, Scalese M, Palladino E, Giordano R, Franchi E, Viacava C, Corana G, Marchese P, Pizzuto A, Assanta N, Santoro G. J Clin Med. 2025 Dec 23;15(1):98. doi: 10.3390/jcm15010098. PMID: 41517351 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Featuring perspectives from Dr Joshua K Sabari, including the following topics: Jänne PA et al. Final analysis results and patient-reported outcomes from DESTINY-Lung02 — A dose-blinded, randomized, phase 2 study of trastuzumab deruxtecan in patients with HER2-mutant metastatic NSCLC. J Thorac Oncol 2025;20(12):1814-28. (0:00) Heymach JV et al. Circulating tumor DNA (ctDNA) analysis following zongertinib treatment (tx) in patients (pts) with human epidermal growth factor receptor 2 (HER2)-mutant non-small cell lung cancer (NSCLC): Phase Ia/Ib Beamion LUNG-1 study. ESMO 2025;Abstract 2020P. (8:30) Schram AM et al. Beamion PANTUMOR-1: Rationale and design of a phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid tumors. Future Oncol 2026;22(7):795-803. (12:53) Johnson ML et al. Beamion LUNG-2: A phase III randomized controlled trial of zongertinib (BI 1810631) versus standard of care in patients with locally advanced/metastatic non-squamous NSCLC harboring HER2 tyrosine kinase domain (TKD) mutations. ASCO 2024;Abstract TPS8654. (19:40) Le X et al. SOHO-02: Phase III trial of BAY 2927088 in patients with locally advanced or metastatic NSCLC with HER2-activating mutations. ASCO 2025;Abstract TPS8648. (21:41) Li BT et al. Open-label, randomized, multicenter, phase 3 study evaluating trastuzumab deruxtecan (T-DXd) as first-line treatment in patients with unresectable, locally advanced, or metastatic non-small cell lung cancer (NSCLC) harboring HER2 exon 19 or 20 mutations (DESTINY-Lung04). ASCO 2022;Abstract TPS9137. (22:59) Jänne PA et al. Trastuzumab deruxtecan for ERBB2-mutant metastatic NSCLC with or without brain metastases: A secondary analysis of randomized clinical trials. JAMA Netw Open 2025;8(11):e2543107. (24:37) CME information and select publications

Featuring perspectives from Dr Joshua K Sabari, including the following topics: Heymach JV et al. Zongertinib in previously treated HER2-mutant non-small cell lung cancer. N Engl J Med 2025;392(23):2321-33. (0:00) Popat S et al. Zongertinib as first-line treatment in patients with advanced HER2-mutant NSCLC: Beamion LUNG-1. ESMO 2025;Abstract LBA74. (5:25) Le X et al. Sevabertinib in advanced HER2-mutant non-small cell lung cancer. N Engl J Med 2025;393(18):1819-32. (12:37) CME information and select publications

Send us Fan MailIn this small prospective pilot study, Adrianne and Nim explore a domain rarely discussed on rounds, how a mother's cardiovascular function in preeclampsia shapes her newborn's circulatory transition. Using maternal echo and neonatal electrical cardiometry across 13 mother-baby dyads, the authors found an inverse relationship: the worse the mother's cardiac function, the higher the neonate's cardiac output, though vascular tone barely budged. It's a compelling hypothesis about placental strain and fetal adaptation. But Nim pushes back hard on the methodology, pairing this paper with a companion study showing electrical cardiometry consistently overestimates cardiac output in neonates, and questioning why daily echoes were performed on these babies but the results never reported.----Linking maternal and neonatal circulation in preeclampsia. Piani F, Annesi L, Degli Esposti D, Vincenzi S, De Crescenzo S, Della Gatta AN, Simonazzi G, Corvaglia L, Martini S.Am J Physiol Heart Circ Physiol. 2026 Mar 1;330(3):H708-H716. doi: 10.1152/ajpheart.00945.2025. Epub 2026 Jan 12.PMID: 41525138 Free article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailIn this retrospective national study, Adrianne and Nim look at 25 years of congenital heart disease mortality in the US using CDC WONDER data. Infant mortality remains staggeringly high (54 per 100,000), and after years of steady decline, it has been climbing again since 2014. Disparities run throughout: higher deaths among males, non-Hispanic Black and American Indian/Alaska Native populations, and in rural, Midwestern regions, pointing more to gaps in access and resources than to disease biology. The conversation also flags a growing, under-discussed problem, an aging adult congenital population outpacing the pediatric one for the first time, with too few specialists trained to care for them.----National Trends and Disparities in Congenital Heart Disease Mortality in the United States, 1999-2024.Raja S, Albrahim MMS, Aldhafeeri BF, Omar AA, Alqadeeb BA, Alhuways MM, Bangaryd AA, Alqahtany MG, Alfaraj AB, Almughyir RS, AlRasheed ST, Alfaifi M. Pediatr Cardiol. 2026 Jan 13. doi: 10.1007/s00246-025-04156-1. Online ahead of print.PMID: 41528440Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

The episode begins with an introduction to the panel and research objectives. This sets the stage for a deeper discussion on how elevated liver copper levels may influence immune resilience in crossbred calves. The panel examines why the impact of excess concentrations of liver copper is significant for animal health. (00:00 – 02:55) Dr. Hansen then provides an overview of the featured Journal of Animal Science study, emphasizing its interdisciplinary approach and the motivation behind evaluating copper status in emerging beef-on-dairy production systems. She also references how excess copper concentrations in the liver can alter expected outcomes. (02:55 – 05:47) As the discussion progresses, the panel highlights how copper accumulates throughout the production cycle, from late gestation through milk replacer feeding. This results in many calves entering the feedlot with elevated liver copper levels. The excess may influence health outcomes. Importantly, the impact of liver copper concentrations in excess is considered in feedlot transition and calf growth. (05:47 – 10:33) A key theme throughout the episode is the concept of subclinical copper toxicity, where animals may experience negative physiological effects without obvious clinical signs. The panel explains how traditional definitions of copper toxicity may overlook subtle yet economically significant impacts on immune function and disease susceptibility, this is particularly important in relation to BRD. In the context of excess liver copper concentrations, even mild impact on metabolic processes is discussed. (10:33 – 12:28) Dr. Hansen then walks through the experimental design, outlining how calves were assigned to high and adequate-copper groups. They were subjected to a controlled BRD challenge that incorporated stress, viral exposure, and bacterial infection. These steps better simulate real-world conditions. The impact of concentrations exceeding normal liver copper thresholds is addressed in their study design. (12:28 – 17:46) The findings reveal that calves with elevated liver copper levels experienced more severe disease outcomes. This includes higher clinical scores, increased lung consolidation, and slower recovery. Therefore, excess copper in the liver clearly demonstrates a measurable impact on calf recovery and health status. (19:18 – 23:50) The panel explores potential mechanisms behind these results, including increased oxidative stress, reduced antioxidant capacity, and disruptions to normal immune signaling pathways. Next, the discussion also examines how excess copper may interfere with nutritional immunity. This happens by altering the balance and movement of other essential trace minerals, such as zinc and iron, during infection. Ultimately, this compromises the animal's ability to respond effectively to disease challenges. (27:17 – 29:10) From a practical standpoint, the episode provides valuable guidance on managing copper supplementation in cattle diets. The panel emphasizes the importance of evaluating total mineral intake across life stages. They recommend carefully formulating diets to avoid over-supplementation. They discuss the challenges associated with reducing liver copper once it has accumulated and the time required to bring levels back into an optimal range. Most notably, managing the impact of excess concentrations in liver copper requires proactive nutrition strategies. (34:26 – 36:07) The episode concludes with a discussion on diagnostic tools and future research needs, including the role of liver biopsies in accurately assessing copper status and the limitations of blood biomarkers. There is also a need for a deeper understanding of mineral dynamics during disease. The panel highlights the importance of industry education and awareness as this issue continues to gain attention. To summarize, the impact of excess liver copper concentrations is a subject demanding ongoing research and producer awareness. (43:12 – 47:15) Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Send us Fan MailIn this systematic review and meta-analysis, Nim and Adrianne dig into just how common brain injury really is in neonates with critical congenital heart disease. Pooling 31 studies spanning two decades, the authors found that nearly 70% of these babies show some form of ischemic brain injury, split roughly between pre-operative and post-operative timing. Counter to what most clinicians would predict, kids who went to surgery earlier (days 4-6) had higher rates of white matter injury than those who waited longer. MRI remained the most sensitive tool for picking up these lesions, well ahead of ultrasound or CT. But the data stops well short of proving these findings predict long-term outcomes, and Nim pushes back on the idea that an abnormal scan alone should steer decisions about whether to operate.----Prevalence of Ischemic Brain Injury in Neonates With Congenital Heart Disease: A Systematic Review and Meta-Analysis.Kim C, Chetan D, Kazazian V, Alzamil J, Chau V, Seed M, Miller SP, Selvanathan T.Neurology. 2026 Feb 10;106(3):e214569. doi: 10.1212/WNL.0000000000214569. Epub 2026 Jan 9.PMID: 41512205Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Featuring perspectives from Dr Mazyar Shadman, including the following topics: The CLL17 trial: Fixed-duration versus continuous targeted treatment for previously untreated chronic lymphocytic leukemia (CLL) (0:00) The AMPLIFY trial: Fixed-duration acalabrutinib combinations for untreated CLL (5:31) Zanubrutinib-based therapy for treatment-naïve CLL (12:32) CME information and select publications

Open vs partial nephrectomy, and open vs robotic prostatectomy - two large randomised trials that did not change surgical practice! Just as important to examine these in GU Cast Journal Club as to examine pivotal trials that did change practice. Today we discuss the EORTC Today we discuss the EORTC 30904 RCT looking at kidney cancer surgery (Eur Urol 2011), and the Brisbane randomised trial of open vs robotic prostatectomy conducted (Lancet 2016). We are delighted to welcome back our GU Cast Journal Club Editors, Dr Carlos Delgado (Mexico City, MEX), and Dr Elena Berg (Munich, GER), along with main GU Cast Hosts, Renu Eapen and Declan Murphy. AN emotional one as Carlos is heading home to Mexico soon! Links to papers below:1. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma Eur Urol 2011 2. Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study Lancet 2016Even better on our YouTube channelAbout GU Cast Journal Club:Each month, two papers are discussed, each of which are of importance to the GU Oncology community. These may be recent papers, or occasionally we will chose a classic landmark paper in GU Oncology. The objective is to draw attention to important papers in GU Oncology, and critique these in a robust manner. The key target audience is trainees working in Urology, Medical Oncology, Radiation Oncology, Nuclear Medicine, and diagnostic specialties such as Radiology and Pathology. But any of our regular audience are likely to enjoy this Journal Club series.

Send us Fan MailNeste episódio, Mariana e Marôla oferecem uma visão abrangente dos avanços e desafios atuais na neonatologia, destacando estudos recentes, discussões sobre práticas clínicas e estratégias de apoio à saúde mental dos pais. A conversa combina atualizações científicas com reflexões sobre a aplicação prática no contexto brasileiro.Relevância da profilaxia com vitamina K e o ressurgimento do risco de sangramento na infância - https://jamanetwork.com/journals/jamapediatrics/article-abstract/2851525Novas evidências sobre o manejo do canal arterial em prematuros e implicações para protocolos clínicos - https://jamanetwork.com/journals/jamapediatrics/fullarticle/2834481?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamapediatrics.2025.1025Uso inovador do purê de banana como espessante seguro para lactentes com disfagia - https://www.nature.com/articles/s41372-026-02765-zEstratégias de suporte psicológico e intervenções para a saúde mental dos pais na UTI neonatal - https://jamanetwork.com/journals/jamapediatrics/article-abstract/2851361?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamapediatrics.2026.2546Participe do CINEO 2026, que acontece em Brasília, DF nos dias 26, 27 e 28 de Novembro e venha nos conhecer pessoalmente. A Incubadora é o Podcast oficial do evento. Inscreva-se agora em: cinco.com.br Não esqueça: você  pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação.Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.orgEvidência, cuidado e contexto brasileiro - esse é o nosso roteiro.

Send us Fan MailWhich PDAs actually need treatment? Can maternal voice and scent shape language outcomes? Should we cool at 35 weeks? And did stepping away from probiotics come at a cost? This week's Journal Club takes on five papers that push back on standard practice. Ben reviews the SMART-PDA trial and a comparative study of PDA pharmacotherapy, Daphna covers the MIND trial on multisensory maternal interventions and a Pediatrix database study on NEC after the FDA probiotic warning, and Ben rounds out the main segment with a national look at hypothermia in 35-week infants with HIE. Ben and Eli wrap the week with Neo News on rising vitamin K refusal.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailWhen the FDA warning landed in late 2023, probiotic use in high-use NICUs collapsed from 86% to under 7% almost overnight. What happened to NEC? This week Daphna brings Tolia and Patel's new Journal of Perinatology analysis of the Pediatrix Clinical Data Warehouse, a natural experiment across 347 NICUs and more than 10,000 extremely preterm infants. Centers that stopped saw NEC climb from 2.7% to 4.4%. Centers that never used probiotics saw nothing change. Ben and Daphna work through the difference-in-differences model, the demographic imbalances, and the uncomfortable question underneath it all. When does data stop and advocacy begin?----Probiotics and necrotizing enterocolitis in preterm infants after the food and drug administration warning actions. Tolia VN, Bennett MM, Handler D, Canvasser J, Greenberg RG, Ursprung R, Ahmad KA, Patel RM.J Perinatol. 2026 Jun 2. doi: 10.1038/s41372-026-02712-y. Online ahead of print.PMID: 42225922Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

What do large registry data reveal about outcomes after intraocular foreign body removal, and how should those findings shape surgical planning and patient counseling? In this episode of New Retina Radio Journal Club with VBS, Jordan Deaner, MD, moderates a discussion with Vaidehi Dedania, MD, and Rehan Hussain, MD, on a 2025 IRIS Registry analysis of nearly 4,800 eyes. The group reviews the delayed timeline of visual recovery, the risk of late complications, and practical guidance on staging surgical intervention and setting realistic expectations in complex trauma cases.

Send us Fan MailCooling works at 36 weeks. At 35 weeks, nobody is sure. Ben brings a new Journal of Perinatology analysis of the National Inpatient Sample, covering 1.4 million infants from 2016 to 2022, asking what happens when therapeutic hypothermia is offered just below the evidence line. Cooled 35-weekers died at higher rates than cooled 36-weekers, but within the 35-week group, cooling changed nothing either way. Coagulopathy rose with cooling. Mediation analysis says it wasn't the cause. Ben and Daphna work through what that leaves us, and why shared decision making and careful documentation carry the weight here----Therapeutic hypothermia and in-hospital mortality in 35-week infants with encephalopathy. Aly H, Eltaly H, Mohamed FA, Saker F, Acun C, Mohamed MA.J Perinatol. 2026 Jun 3. doi: 10.1038/s41372-026-02738-2. Online ahead of print.PMID: 42236997Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Seenu Susarla, MD, discuss the following articles from the July 2026 issue: "The APERT Severity Scale: A Quantitative Tool for Risk Stratification in Apert Syndrome" by Hu, Tolley, et al. Read the article for FREE: https://bit.ly/APERTscale Dr. Susarla earned his undergraduate degree from Princeton University, his medical and dental degrees from Harvard, and his MPH from the Harvard School of Public Health. He completed residencies in oral and maxillofacial surgery at Massachusetts General Hospital and plastic surgery at Johns Hopkins, followed by a craniofacial surgery fellowship at Seattle Children's. He has authored more than 250 peer-reviewed publications and numerous textbook chapters, and serves on the editorial boards of several journals, including Plastic and Reconstructive Surgery. READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJuly26Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.  

Send us Fan MailIn this Journal Club, Daphna takes the reins with the MIND randomized controlled trial from Nathalie Maitre and colleagues in The Journal of Pediatrics. Can a multisensory bundle, combining infant-directed voice, a parent's scent, holding, and gentle containment, do more for a preterm baby's developing brain than recorded voice alone? Using event-related potentials to track how infants tell speech sounds apart, the team followed language outcomes all the way to age two. Daphna and Ben unpack the design, the Bayley and PLS-5 findings, and a takeaway every clinician can act on tomorrow. Talk to the baby, every single time.----The MIND Randomized Controlled Trial: An Intervention to Improve Neural Speech Processing and 2-Year Language Outcomes of Infants Born Preterm. Maitre NL, Kjeldsen CP, Jeanvoine A, Lukemire J, Slaughter JL, Key AP.J Pediatr. 2026 Jun 5:115187. doi: 10.1016/j.jpeds.2026.115187. Online ahead of print.PMID: 42250747Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailIn this Journal Club, Ben and Daphna dig into two new papers on PDA management in our smallest patients. First, the SMART-PDA pilot RCT from Souvik Mitra and colleagues, which uses comprehensive hemodynamic screening to selectively treat high-volume shunts in infants born before 26 weeks, and whose striking Bayesian signal for reduced pulmonary hemorrhage and NEC stopped the trial early. Then a companion JAMA Network Open comparative effectiveness study across four pharmacotherapy regimens. Along the way, Ben shares hemodynamics pearls from his Montreal training: why left ventricular output, LA:Ao ratio, and transductal velocity matter more than PDA diameter alone.----Selective early medical treatment of the patent ductus arteriosus in extremely low gestational age infants: a pilot randomised controlled trial (SMART-PDA). Mitra S, Hebert A, Castaldo MP, Disher T, El-Naggar W, Dhillon S, Alhassen Z, Koo J, Katheria AC, Hyderi A, Kumaran K, Ting J, Surak A, Larocque J, Pepper D, Hornberger L, Makoni M, Weisz DE, Jain A, Bacchini F, Cameron-Nola AJJ, Hatfield T, Dorling J, McNamara PJ, Thabane L.Arch Dis Child Fetal Neonatal Ed. 2026 May 18:fetalneonatal-2026-330462. doi: 10.1136/archdischild-2026-330462. Online ahead of print.PMID: 42150872Pharmacologic Therapies for Patent Ductus Arteriosus in Extremely Preterm Infants. Mitra S, Jain A, Ting JY, Ben Fadel N, Drolet C, Abou Mehrem A, Soraisham AS, Jasani B, Louis D, Lapointe A, Dorling J, Khurshid F, Hyderi A, Kumaran K, Toye J, Harabor A, Weisz DE, Stavel M, Morin A, Bhattacharya S, Lalitha R, Afifi J, Augustine S, Castaldo MP, Hatfield T, Su YC, Shah PS; Canadian Neonatal Network Investigators.JAMA Netw Open. 2026 Jun 1;9(6):e2617477. doi: 10.1001/jamanetworkopen.2026.17477.PMID: 42262753 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Join us for the July edition of the Simulcast Journal Club, hosted by Vic Brazil and Ben Symon. In this episode: AI and debriefing, ‘code-switching' as a source of cognitive load in sim. Facilitator cognitive load, and longitudinal evaluation of undergraduate simulation programs.    The July papers  Stocks L, Place M, Brazil V, Kainth R, Lowe B, Khan I, et al. AI integration in healthcare simulation debriefing: support or substitute? Adv Simul (Lond). 2026.   Roe R. Code-switching in simulation-based nursing education: a cognitive load theoretical framework Clin Simul Nurs. 2026;116:101991.   Vaughn J, Ford SH, Pike G, Suplee PD. Reducing cognitive load for simulation facilitators: a cross-sectional pilot study. Clin Simul Nurs. 2026;116:101980.   Weyer G, Haegdorens F, Vleminckx S, Hilderson D, Franck E. Self-confidence and anxiety in clinical decision-making among nursing students during high-fidelity simulation training: a longitudinal study. Adv Simul (Lond). 2026.     Happy listening   vb  Also ….. Your next simulation conference – National Health Simulation Conference 2026. QT Gold Coast, Australia.  October 21-22  Registration open now - HERE    

Drs. Kat Talcott and Akshay Thomas join for a journal club podcast discussion:‍‍Mark Cuban Cost Plus Ophthalmology Medications (https://www.aaojournal.org/article/S0161-6420(26)00378-7/fulltext)Resident Continuity Clinics (https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2848897)PDR Long-Term Outcomes (https://www.ophthalmologyretina.org/article/S2468-6530(26)00218-6/abstract)Marginal Outer Retinal Ridge in PDR (https://www.ophthalmologyretina.org/article/S2468-6530(26)00274-5/abstract)‍ ‍

Gout Journal Club will examine two influential publications: 1. "Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients with Gout" (Cipolletta et al., JAMA Internal Medicine, 2026) and 2. "Target Serum Urate Achievement and Chronic Kidney Disease Progression in Patients With Gout and Kidney Disease"(Wang et al., JAMA Internal Medicine, 2025). Together, these studies provide new evidence supporting treat-to-target urate-lowering strategies and their potential impact on cardiovascular and renal outcomes. Panelists: Abhishek Abhishek, MD, PhD, MBBS, FRCP Zeqin Wen, MD Jie Wei, PhD Jack Cush, MD (moderator) Beyond reviewing the evidence, our expert panel will tackle the practical questions rheumatologists face every day.

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Seenu Susarla, MD, discuss the following articles from the July 2026 issue: "Craniofacial Symmetry Progression following Strip Craniectomy in Unilateral Coronal Carniosynostosis" by Harrison, Hallac, et al. Read the article for FREE: https://bit.ly/CranioProgression Dr. Susarla earned his undergraduate degree from Princeton University, his medical and dental degrees from Harvard, and his MPH from the Harvard School of Public Health. He completed residencies in oral and maxillofacial surgery at Massachusetts General Hospital and plastic surgery at Johns Hopkins, followed by a craniofacial surgery fellowship at Seattle Children's. He has authored more than 250 peer-reviewed publications and numerous textbook chapters, and serves on the editorial boards of several journals, including Plastic and Reconstructive Surgery. READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJuly26Collection  The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Send us Fan MailNeonatal sepsis physiology, steroids, vasopressors, and moms.gov. A full week on The Incubator Journal Club.Adrianne and Nim open with a retrospective study from Toronto challenging the assumption that hypoxemic respiratory failure in septic preterm infants is driven by elevated pulmonary vascular resistance. The data points instead to left ventricular dysfunction as a key contributor, raising questions about the reflex to reach for nitric oxide first.Nim then reviews a double-blind RCT from northern India evaluating early hydrocortisone versus placebo in neonatal fluid-refractory shock. The primary outcome did not reach statistical significance, but an 11 percent absolute reduction in mortality and a 70 percent open-label crossover rate tell a story of their own.Adrianne closes the journal club with a double-blind RCT comparing norepinephrine to dopamine for neonatal septic shock, finding no significant difference in shock reversal at 30 minutes, though significant methodological limitations make the findings hard to act on.Eli and Ben close the week on Neo News with a look at the newly launched moms.gov and what clinicians should know before their patients bring it up.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailIn this double-blind randomized controlled trial, Adrianne and Nim examine whether norepinephrine outperforms dopamine as a first-line vasoactive agent in neonates with fluid-refractory septic shock. The primary outcome, shock reversal at 30 minutes, was not significantly different between groups, at 32 percent for norepinephrine and 46 percent for dopamine. Secondary outcomes including mortality, IVH, NEC, and need for additional vasoactive support were also similar. The episode critically examines the methodological limitations of the study, including unclear sepsis definitions, absence of echo phenotyping, and unusually high starting doses, and asks whether the field needs better tools before these questions can be properly answered.----Norepinephrine versus Dopamine for Septic Shock in Neonates: A Randomized Controlled Trial.Mazhari MYA, Priyadarshi M, Singh P, Chaurasia S, Basu S.J Pediatr. 2025 Jul;282:114599. doi: 10.1016/j.jpeds.2025.114599. Epub 2025 Apr 17.PMID: 40252959 Clinical Trial.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Seenu Susarla, MD, discuss the following articles from the July 2026 issue: "Long-Term Outcomes following Craniosynostosis Corrections: A 30-Year Retrospective" by Coombs, Ditthakasem, et al. Read the article for FREE: https://bit.ly/LongTermCranio Dr. Susarla earned his undergraduate degree from Princeton University, his medical and dental degrees from Harvard, and his MPH from the Harvard School of Public Health. He completed residencies in oral and maxillofacial surgery at Massachusetts General Hospital and plastic surgery at Johns Hopkins, followed by a craniofacial surgery fellowship at Seattle Children's. He has authored more than 250 peer-reviewed publications and numerous textbook chapters, and serves on the editorial boards of several journals, including Plastic and Reconstructive Surgery. READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJuly26Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Send us Fan MailIn this double-blind randomized controlled trial from northern India, Nim and Adrianne review whether early hydrocortisone reduces 14-day all-cause mortality in preterm infants with fluid-refractory shock. The primary outcome showed no statistically significant difference between groups, though an 11 percent absolute reduction in mortality in the hydrocortisone group raised clinical interest. A major limitation was the high rate of open-label steroid crossover, with over 70 percent of both groups ultimately receiving hydrocortisone. The study highlights the difficulty of achieving equipoise when clinicians already believe strongly in a therapy, and raises important questions about study design in neonatal shock research.----Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial. Dudeja S, Saini SS, Sundaram V, Dutta S, Sachdeva N, Kumar P.J Perinatol. 2025 Mar;45(3):342-349. doi: 10.1038/s41372-025-02222-3. Epub 2025 Feb 13.PMID: 39948354 Clinical Trial.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

The episode opens with introductions to the panel and co-host Dr. Mariana Marenho, highlighting her background in ruminant nutrition and setting the stage for a discussion that bridges academic research with real-world application. (00:00 – 01:27)  The conversation then introduces the featured Journal of Dairy Science review paper, focusing on the regulation of hepatic glucose production “carbon by carbon.” Dr. White shares how the paper originated from an invited symposium and the collaborative effort to connect detailed biochemical mechanisms with practical dairy nutrition strategies. (01:27 – 04:15)  The discussion quickly centers on a foundational concept in ruminant biology: dairy cows must synthesize nearly all their glucose internally. Unlike monogastrics, cows rely on hepatic gluconeogenesis to generate the large amounts of glucose needed to support lactose production—and therefore milk yield—making this process essential for performance. (04:15 – 08:44)  From there, the panel explores how glucose production directly drives milk synthesis, emphasizing that lactose production determines milk volume. This creates a continuous metabolic demand on the liver, requiring cows to sustain high rates of glucose production throughout lactation. (08:44 – 09:53)  The discussion then shifts into the primary substrates for gluconeogenesis, including propionate, amino acids, lactate, and glycerol. The panel explains why propionate is the dominant precursor in fed cows and how efficient rumen fermentation is critical to supporting glucose supply. (09:53 – 11:13)  The conversation also revisits the concept of bypass starch, challenging the idea that delivering glucose directly to the small intestine can offset hepatic glucose production. The panel explains how glucose sparing mechanisms in ruminants limit the effectiveness of this strategy, as absorbed glucose is often utilized by other tissues instead of supporting milk production. (11:13 – 13:17)  Attention then turns to practical feeding strategies, particularly how to increase propionate supply through forage quality, rumen fermentation management, and dietary tools such as ionophores and targeted supplements. These approaches help ensure that cows have adequate precursors to meet their genetic potential for milk production. (13:17 – 14:29)  The episode also dives deeper into nutrient partitioning and metabolic regulation, highlighting how the availability of precursors must align with gene expression and enzyme activity. The panel discusses how nutrients like choline can influence gluconeogenesis not just as substrates, but as regulators of metabolic pathways. (14:29 – 27:30)  From a management perspective, the panel emphasizes foundational practices such as high-quality forages, consistent feed intake, and transition cow management. Maintaining rumen health and minimizing disruptions in feeding behavior are critical for supporting stable nutrient supply and efficient glucose production. (27:30 – 30:07) The discussion also explores the impact of feeding behavior, competition, and daily nutrient flow, showing how disruptions in intake patterns can affect rumen fermentation dynamics and ultimately nutrient partitioning within the cow. (30:07 – 32:31)  Finally, the episode examines the role of genetics and future research opportunities, noting that modern dairy cows already have increased gluconeogenic capacity due to selection for higher milk production. The remaining challenge lies in optimizing nutrition and management to fully support that genetic potential. (34:32 – 37:14)  The episode concludes by emphasizing the importance of integrating fundamental biochemical research with practical feeding strategies, reinforcing that understanding metabolism at a deeper level can lead to more precise and effective nutrition programs on farm.  Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Send us Fan MailIn this retrospective single-center study from Toronto, Adrianne and Nim explore the echo findings of preterm infants with septic shock and hypoxemic respiratory failure. Contrary to the common assumption that elevated pulmonary vascular resistance drives hypoxemia in sepsis, the data points to left ventricular dysfunction as a key contributor. Babies with hypoxemic respiratory failure showed lower LV systolic and diastolic performance, while pulmonary pressures were similar between groups. Mortality was significantly higher in the hypoxemic group. This challenges the reflex to reach for nitric oxide first and asks clinicians to look at the whole heart.----Cardiopulmonary Physiology of Hypoxemic Respiratory Failure Among Preterm Infants with Septic Shock. Kharrat A, Nissimov S, Zhu F, Deshpande P, Jain A.J Pediatr. 2025 Mar;278:114384. doi: 10.1016/j.jpeds.2024.114384. Epub 2024 Nov 6.PMID: 39510164Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Each month on the APN Discord channel the management of the APN will get together and discuss an article or two from recent archaeology and scientific journal publications. You can join live and free on the Discord and see our shining faces! We thought we'd use this show to present the audio from that first recording. We're aiming for the first Monday of every month. Let us know what you think! Links https://www.newscientist.com/article/2526391-ancient-teeth-hint-at-links-between-denisovans-and-homo-erectus/ Apple News: https://apple.news/AzsyzHT5XQyGJc7jweQl4mg Contact Chris Webster chris@archaeologypodcastnetwork.com Rachel Roden rachel@unraveleddesigns.com RachelUnraveled (Instagram) ArchPodNet APN Website: https://www.archpodnet.com APN Discord: https://discord.com/invite/CWBhb2T2ed APN on Facebook: https://www.facebook.com/archpodnet APN on Twitter: https://www.twitter.com/archpodnet APN on Instagram: https://www.instagram.com/archpodnet APN Shop Affiliates Motion Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Devinder Singh, MD, discuss the following articles from the June 2026 issue:   "Efficacy of Nanofat in Wound Healing: A Double-Blinded Randomized Controlled Trial" by Wongkietkachorn and Wongkietkachorn.   Read the article for FREE: https://bit.ly/Nanofat_WoundHealing   Devinder Singh, MD, is the Chief of the Division of Plastic and Reconstructive Surgery, Program Director, and a Professor of Surgery (and secondary professor of dermatology) at the University of Miami Miller School of Medicine.  READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJune26Collection   The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Carepoint Journal Club is a quarterly series with discussions about a medical topic, brought to you by Carepoint's Emergency Physicians.

Send us Fan MailPhototherapy duration, jaundice and UTIs, extended CPAP, and The Pitt. A full week on the Incubator Journal Club.Ben opens with a nationwide Swedish cohort study from JAMA Network Open examining phototherapy duration in nearly 5,000 very preterm infants. Longer phototherapy was not significantly associated with late neonatal mortality, but six to seven days was associated with significantly higher rates of severe neonatal morbidity. With 95% of the cohort receiving phototherapy, Ben and Daphna question how much evidence actually supports the near-universal practice.Daphna follows with a retrospective study from Istanbul showing that 31% of term and near-term neonates hospitalized for unexplained hyperbilirubinemia had culture-proven UTIs, with pathological renal ultrasound findings independently associated with a 4.6-fold increased odds of UTI.Ben then reviews the extended CPAP secondary analysis by Mamidi and McEvoy, showing that two additional weeks of bubble CPAP reduced intermittent hypoxemia episodes from 151.7 to 57.6 compared to discontinued CPAP.Daphna closes with the NEOASP five-day UTI treatment guideline from Nationwide Children's Hospital, where a structured stewardship approach yielded a 1% failure rate.Ben and Eli close the week reflecting on The Pitt and what it reveals about the broken realities of American healthcare.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!