Podcasts about GLP

Your brain encounters more information in 24 hours than people in the 1970s absorbed in an entire month. The world is accelerating—but cognitive decline is not inevitable. In this episode, Dr. Caroline Leaf—clinical and research neuroscientist with over 40 years of work in directed neuroplasticity—shares 7 powerful strategies to future-proof your mind, brain, and body for the decades ahead. You'll learn how to strengthen cognitive flexibility, regulate your emotions under pressure, develop predictive awareness, and build the mental architecture your brain will rely on for the next 50 years. Whether you're in your 30s, 50s, or 70s, your brain retains the ability to change. The key is learning how to direct that change intentionally.

Today, I had the honor of connecting with Ashley Koff. She is a leading voice in personalized nutrition and the founder of the Better Nutrition Program. With over 25 years of experience and the groundbreaking GLP-1 Optimization System to her name, she's helped redefine how we approach sustainable weight health. In our conversation, we dive into how her book reframes the concept of healthy weight. We explore integrative perspectives on digestive health and GLP-1s, why many women blame themselves when they struggle to lose weight, and how Ashley's framework helps them remove that self-blame. We also discuss issues surrounding info-besity and the “less is more” approach, natural ways to support appetite regulation and satiety signaling, key areas of digestive health, and the importance of detoxification. Ashley also shares the red flags she sees in women who are undernourishing themselves or over-fasting, things to consider when you want to stop taking GLP-1s, and her opinions on new drug therapies. Join us for today's thought-provoking and insightful conversation around metabolic health and weight-loss resistance for women in middle age, perimenopause, and menopause. IN THIS EPISODE, YOU WILL LEARN: The interconnection that exists between digestion, hormones, and metabolic signaling How the hormonal fluctuation that occurs in perimenopause disrupts women's digestion What drives satiety?  How GLP-1 medications simply amplify, extend, or mimic an existing communication loop within the body rather than creating new pathways Why do women blame themselves when they cannot lose weight? How info-besity blocks the body from doing what it is naturally designed to do  Why detoxification is essential for supporting natural digestive and metabolic processes The red flags that indicate undernourishment or over-fasting in women What you need to think about before stopping GLP-1s Bio: Ashley Koff, RD, is the USA Today bestselling author of⁠ Your Best Shot⁠ (HarperOne) and founder of⁠ The Better Nutrition Program⁠ (BNP). An acclaimed weight-health expert and practitioner for more than 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real outcomes. Your Best Shot introduces weight-health hormones (GLP-1, GIP, CCK, PYY) as the regulators of weight health, offering the first-ever assessment of their function and a personalized optimization system—shot or not. A trusted expert featured across major media and a sought-after educator for health professionals, Ashley has been recognized as one of CNN's Top 100 Health Makers and featured in InStyle as “Hollywood's Leading Dietitian.” Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia's ⁠website⁠ Submit your questions to ⁠support@cynthiathurlow.com⁠ Join other like-minded women in a supportive, nurturing community:⁠ The Midlife Pause/Cynthia Thurlow⁠  Cynthia's⁠ Menopause Gut Book⁠ is on presale now! Cynthia's⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause Supplement Line⁠ Connect with Ashley Koff ⁠The Better Nutrition Program⁠  On ⁠Instagram⁠ and⁠ Substack⁠ On other social media: @Ashley Koff

As women, we're told our bodies are wrong almost from the moment we become aware of them—and that messaging hits hyperdrive when the body composition changes of menopause arrive. Those changes are often framed as urgent health risks, even when the picture is far more nuanced and the steps taken to “fix” them can carry risks of their own. This week we sit down with dietitian and public health nutrition specialist Diana Reid to dig into what actually drives midlife weight gain, what belly fat and BMI do (and don't) mean for your health, and where GLP-1 medications fit into the picture. We talk muscle and bone loss, under-fueling, weight regain, and how to protect your health if you choose to use weight loss medications.Diana Reid is a Registered Dietitian-Nutritionist licensed in both the United States and Luxembourg. She's originally from Seattle, but has been living in Europe since 2016. Diana has a masters degree in Public Health & Nutrition and specializes in nutritional counseling and support for patients with eating disorders; food allergies, intolerances and gut disorders; and the unique challenges related to women's health, especially during midlife and the menopause transition. She is a Certified Intuitive Eating Counselor and follows a non-diet, weight-neutral approach to health and wellness, focusing on habit building, lifestyle behaviors and balanced nutrition. She believes in practicing with compassion, understanding, and a personalized approach to nutrition and well-being. Diana is a married midlife menopausal mom of three teens and a clingy dog, and loves cycling, weight lifting, hiking and traveling. You can find her on social media at @theglobalrd or via her website at www.theglobaldietitian.comResources:Weight Cycling as a Risk Factor for Low Muscle Mass and Strength in a Population of Males and Females with Obesity, hereFull resource list for this episode hereSign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Learn More about our 2026 Feisty Events, including Bike Camps and Cycling Trips: https://feisty.co/events/Follow Us on Instagram:Feisty Menopause: @feistymenopauseHit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code STAYFEISTY for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Wahoo: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

On this week's Ticked Off Tuesday, Jared kicks things off fresh off his birthday, unpacking the emotional crash that hits the second your “birthday week” excuses expire, and real life comes rushing back in. He spirals into a hilarious rant about people still posting happy birthdays on Facebook, questioning whether it's kindness or pure notification-driven obligation. Listener complaints bring the chaos, including a family feud sparked by a shockingly low shrimp count in shrimp fried rice, the frustration of unreadable text messages on TV shows, and Walmart pickup parking spots being hijacked by rule-ignoring shoppers. Jared also weighs in on algorithm fatigue after one exhausted mom gets flooded with GLP-1 weight loss ads while breastfeeding and just trying to scroll in peace. It's a cathartic episode full of petty grievances, modern annoyances, and the oddly comforting joy of complaining together!Jared is on tour!

Butyrate is a short-chain fatty acid (SCFA) produced when gut bacteria ferment dietary fiber. It serves as the primary fuel for colon cells, including L-cells that produce GLP-1 When your gut produces enough butyrate, natural GLP-1 secretion works properly, supporting appetite control, insulin sensitivity, and weight regulation This butyrate-driven GLP-1 pathway represents your body's built-in weight management system. My new book, "Weight Loss Cure; Melt Fat Naturally With Your Own GLP-1," provides a step-by-step plan to rebuild butyrate production, restore natural GLP-1 signaling, and correct the root drivers of weight gain Low butyrate production disrupts GLP-1 signaling and contributes to obesity, insulin resistance, and metabolic disease Beyond weight regulation, butyrate also supports gut integrity, immune balance, and protection against chronic disease

My new book, "The Weight Loss Cure," offers a step-by-step guide to rebuilding your gut ecosystem so you can restore your body's natural weight-control system — no injections required Your gut produces the same GLP-1 hormone that weight-loss drugs like Ozempic mimic, meaning your body already has the natural machinery for appetite control and fat burning Damage from seed oils and low-fiber diets weakens your gut barrier, disrupts GLP-1 signaling, and causes inflammation that blocks weight loss A key gut bacterium called Akkermansia muciniphila helps repair your gut lining, balance blood sugar, and promote natural fat loss — even in its pasteurized, non-living form Restoring gut health begins with repairing the barrier, reducing linoleic acid intake, and gradually reintroducing diverse fibers to produce "Gut Gems" like butyrate that calm inflammation and stabilize metabolism

GLP-1 weight-loss drugs such as Ozempic, Wegovy, Mounjaro and Zepbound are reshaping the treatment of obesity around the world. But even when these medicines are judged “cost-effective”, access often depends on who can afford to pay. In the second episode of our Business Daily series on the global weight-loss economy, Sam Fenwick examines how different countries are funding — or rationing — access to these high-priced injections. In England, the state's National Health System says the drugs offer good value for money, and yet rollout is being phased in slowly because of cost and capacity pressures. In the United Arab Emirates, most patients rely on private insurance or pay out of their own pockets. And in India, where obesity is rising fast, affordability remains a major barrier, although lower-cost generics may soon change that. If these medicines can prevent diabetes, heart attacks and strokes, they might save health systems money in the long run. But right now, governments, insurers and patients are grappling with the same question: Can we afford the weight-loss revolution?Produced and presented by Sam FenwickIf you'd like to get in touch with the team, our email address is businessdaily@bbc.co.ukBusiness Daily is the home of in-depth audio journalism devoted to the world of money and work. From small start-up stories to big corporate takeovers, global economic shifts to trends in technology, we look at the key figures, ideas and events shaping business.Each episode is a 17-minute deep dive into a single topic, featuring expert analysis and the people at the heart of the story.Recent episodes explore the growth in AI, the cost of living, why bond markets are so powerful, China's property bubble, and Gen Z's experience of the current job market.We also feature in-depth interviews with company founders and some of the world's most prominent CEOs. These include Google's Sundar Pichai, Wikipedia founder Jimmy Wales, CEO of Canva Melanie Perkins, and the CEO of Starbucks, Brian Niccol.(Photo: A man gets his waist measured. Credit: Getty Images)

Did millennial women grow up inside a system designed by powerful men? In this episode, Maria is joined by journalist Ileana Justine to unpack how mall culture, Victoria's Secret, JUICY sweatpants, low-rise jeans, and dress code "fingertip rules" shaped millennial body image, and how the Jeffrey Epstein era exposed who held the power behind those brands. They break down the male gaze vs. the female gaze, trad wife influencers, the "provider" debate in modern dating, GLP-1 skinny culture, and how shows like Grey's Anatomy changed women's dating standards. Plus, a listener asks how to date confidently after major surgery, weight changes, and visible scars. This is a deep dive into cultural conditioning, patriarchy, body image, and how it all affects who we choose to love.   ♥️JOIN MARIA'S COMMUNITY + SUBMIT A QUESTION ❓ Ready to date with intention?

Most people obsess over lifespan—but what if the real metric that matters is healthspan? In this powerful conversation, Dr. JC Doornick sits down with world-renowned longevity expert Oz Garcia to unpack why so many people feel depleted, foggy, and biologically older than their years—even when their labs say they're “fine.” From post-COVID fatigue and chronic inflammation to mitochondrial health, cellular energy, brain vitality, and the responsible use of peptides as signaling molecules, this episode dives deep into what actually drives aging—and how to reverse the biological drift. If you've been asking, “Why am I always tired?” or wondering how to stay sharp, resilient, and fully alive after 40 or 50, this conversation will reframe everything you thought you knew about longevity. This isn't about hacks. It's about protecting your energy, preserving your brain, and staying in the game for decades to come. Connect with Oz Garcia: Website: www.ozgarcia.com IG - / @ozwellness   Dr. JC Doornick Links: Website - www.makessensebook.com YT -    / @drjcdoornick IG -   / @drjcdoornick FB -   / @makessensepodcast Makes Sense Book - https://tinyurl.com/makessensepurchase MAKES SENSE PODCAST Welcome to the Makes Sense with Dr. JC Doornick Podcast. This podcast explores topics that expand human consciousness and enhance performance. On the Makes Sense Podcast, we acknowledge that it's who you are that determines how well what you do works, and that perception is subjective and an acquired taste. When you change the way you look at things, the things you look at begin to change. Welcome to the uprising of the sleepwalking masses. Welcome to the Makes Sense with Dr. JC Doornick Podcast. SUBSCRIBE/RATE/REVIEW & SHARE our new podcast. FOLLOW Podcast: You will find a "Follow" button in the top right. This will enable the podcast software to alert you when a new episode launches each week. Apple: https://podcasts.apple.com/ca/podcast/makes-sense-with-dr-jc-doornick/id1730954168 Spotify: https://open.spotify.com/show/1WHfKWDDReMtrGFz4kkZs9?si=003780ca147c4aec Podcast Affiliates: Kwik Learning: Many people ask me where I get all these topics, which I've been covering for almost 15 years. I have learned to read nearly four times faster and retain information 10 times better with Kwik Learning. Learn how to learn and earn with Jim Kwik. Get his program at a special discount here: https://jimkwik.com/dragon OUR SPONSORS: Makes Sense Academy: A private mastermind and psychologically safe environment full of the Mindset and Action steps that will help you begin to thrive. The Makes Sense Academy. https://www.skool.com/makes-sense-academy/about The Sati Experience: A retreat designed for the married couple that truly loves one another, yet wants to take their love to that higher magical level. Relax, reestablish, and renew your love at the Sati Experience. https://www.satiexperience.com   0:00 - Intro 2:48 - What I like about Dr. OZ Garcia 5:57 - Lifespan vs. Healthspan? 8:25 - What's your position on the advancement of tech and lifespan 14:05 - The Better Educated Consumer of the Future 18:24 - Why do people feel biologically older while we are projecting a longer lifespan? 21:38 - Post Coved Chronic Inflammation and Fatigue 28:12 - What Causes Brain Fog - Is Cognitive Decline Reversible? 32:59 - Brain Optimization and Reducing Risk of Dementia and Alzheimer's 38:48 - What are the Top Three Most Essential Supplements to Take? 42:21 - What's the Buzz about Peptides, what are they, and why are they important? 47:33 - What is your take on GLP-1's and what is their correlation to longevity? 52:30 - What does Quality of Life Mean to You? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Know When It's Time to Cut The #1 reason why people CONSISTENTLY fail. (1:46) What does it mean to go on a cut? (4:01) The definition of a successful cut. (4:22) The reasons you should NOT go on a cut. 1. When you feel you're too fat. (7:08) 2. To get ready for an "event." (9:39) The reasons it's a good time to cut. 1. You are healthy. (11:49) 2. Your maintenance calories are high enough to cut from. (14:12) 3. You have a good plan, which includes how to stop. (23:58) Related Links/Products Mentioned Mind Pump Concierge Coaching (Only 50 spots open) – Visit: www.mindpumpconcierge.com  Visit Joymode for an exclusive offer for Mind Pump listeners! ** Enter MINDPUMP at checkout for 20% off your first order. ** MAPS Great 8 Launch - (Retail $127, Code: LAUNCH for 50% off!) ** Launch bonus include: MAPS GREAT 8 Nutrition Guide. ** Visit: http://mapsgreat8.com/  Mind Pump Store Mind Pump # 2187: Why Building Muscle Is More Important Than Losing Fat With Dr. Gabrielle Lyon Mind Pump # 2690: The NEW DIET Everyone Is Using For Fat Loss Mind Pump # 2410: How to Maximize Fat Loss & Preserve Muscle on GLP-1s (Introducing MAPS GLP-1) Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Corinne Schmiedhauser (@mindpumpcorinne) Instagram  

Dave makes an Italian Sunday dinner of braciola and red sauce for "Cousin Sal" Iacono, sports gambling enthusiast and prankster. Dave also surprises Sal with two dishes that Dave didn't make, including his favorite sandwich in Los Angeles. The duo discusses a buffet's worth of topics, from GLP-1s to sandwiches, sports betting to why Vegas is struggling, and hot dog–eating contests. They finish with a game of Inappropriate Dinner Conversations, which gets a little NSFW and a lot character-revealing. Learn more about The Masters: https://www.masters.com/index.html Learn more about Dave and Buster's: https://www.daveandbusters.com Learn more about The French Laundry Cookbook by Thomas Keller: https://amzn.to/4aRjBMr Learn more about White House Subs: https://www.whitehousesubshop.net/ Learn more about Bianco: https://www.pizzeriabianco.com/ Host: Dave Chang Guest: "Cousin Sal" Iacono Majordomo Media Producer: David Meyer Spotify Producer: Felipe Guilhermino Additional Crew: Jake Loskutoff, Dionte Mercado, Dan McCoy, Michael Delgado, Abby Zidonis Editor: Jake Loskutoff Learn more about your ad choices. Visit podcastchoices.com/adchoices

Mazel morons! This week we welcome Dr. Craig Koniver (Josh's wellness wizard- not the Southern Charm star) to break down peptides, GLP-1s, methylene blue, muscle loss myths, and why half the internet is buying research-grade chemicals with “not for human use” on the label. Plus: bungalow discourse, Jewish kiddush engineering, microdosing Judaism, Botox myths, hair loss panic, and why Ben once accidentally did ketamine in a bathroom for 90 minutes. What are ya nuts?!Write in your questions to goodguyspodcast1@gmail.com!Follow us on Instagram and TikTok! Sponsors:Grab Goodwipes for free at Walmart so you can upgrade your restroom routine! Buy any one, two or three pack in Walmart or Walmart.com, text them your receipt, and get reimbursed almost immediately. For more details, head to goodwipes.com/GOODGUYS.Right now, Mizzen & Main is offering our listeners 20% off your first purchase at mizzenandmain.com, promo code goodguys20Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the reason fat loss feels impossible is not willpower, not discipline, and not “eat less, move more” but your hormones, your hunger, and your body's fat thermostat? In this episode of The Ben Azadi Show, Ben welcomes back Dr. Jason Fung to break down why most weight loss advice fails long term and why obesity and type 2 diabetes are not calorie problems, they are hormonal problems. Dr. Fung explains how insulin acts as a fat storage signal, why fasting insulin and C-peptide can reveal metabolic dysfunction years before A1c rises, and how hunger is the real problem behind overeating. He also introduces key ideas from his new book, The Hunger Code, including the fat thermostat, the “three whys,” and the three types of hunger: physical, emotional, and conditioned. You will walk away with a clearer framework for sustainable fat loss that works with human physiology instead of fighting it. Key Topics Covered Why “eat less, move more” has an extremely high long-term failure rate Calories vs hormones: why the body can store or burn the same calories differently Insulin's role in fat storage and fat burning shutdown Insulin resistance as “overflow,” not “under-fuel” Why fasting insulin and C-peptide matter earlier than A1c The fat thermostat concept and why metabolism adapts fast Hunger hormones and satiety signals (including GLP-1 related discussion) The “three whys” framework for getting to the root cause of weight gain The 3 types of hunger: homeostatic, hedonic, and conditioned hunger Why ultra-processed foods reshape hunger and behavior Why low insulin matters more than “low carb” for many people How environment and community influence obesity risk and habits Resources & Special Offer Dr. Jason FungWebsite: https://www.doctorjasonfung.com/ Book: The Hunger Code (Release Date: March 3) Pre-order the book through Dr. Jason Fung's website to receive exclusive bonuses, including a free masterclass and additional resources. Follow Ben Azadi

What if being “good” was never meant to protect us?In this powerful conversation, I'm joined by the incredible Savala Nolan (back for the second time) to talk about her new book Good Woman: A Reckoning, which is a lyrical, unflinching exploration of the expectations placed on women's bodies, voices, marriages, appetites, and lives.We explore what happens when the bargain of goodness stops “working” and what becomes possible when we refuse it.Tune in for more on:* The myth that being “good” (thin, quiet, agreeable) will keep women safe* Midlife as rupture: dieting, divorce, and the unraveling of social conditioning* Body liberation as a daily practice — especially in the age of GLP-1s* What it means to become “illegible” to misogynistic culture* Raising daughters who are fluent in their bodies, not afraid of themThis is a conversation about wilderness, refusal, and the kind of freedom that feels both exciting and terrifying because of its importance and truth.Find Savala on IG: https://www.instagram.com/savalanolan/Order "Good Woman" here: https://savalanolan.com/Savala's Substack: https://savala.substack.com/Support the show: Enjoying this podcast? Please support the show on Substack for bonus episodes, community engagement, and access to "Ask Abbie" at abbieattwoodwellness.substack.com/subscribe Apply for Abbie's Group Membership:Already been at this anti-diet culture thing for a while, but want community and continued learning? Apply for Abbie's monthly membership: https://www.abbieattwoodwellness.com/circle-monthly-group Social media:Find the show on Instagram: @fullplate.podcastFind Abbie on Instagram: @abbieattwoodwellness Podcast Cover Photography by Anya McInroyPodcast Editing by Brian WaltersThis podcast is ad-free and support comes from your support on Substack. Subscribe HERE. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit abbieattwoodwellness.substack.com/subscribe

GLP-1 weight-loss drugs such as Ozempic, Wegovy, Zepbound and Mounjaro are reshaping the treatment of obesity — and transforming the global pharmaceutical market.Originally developed to treat type-2 diabetes, these injectable medicines — including semaglutide and tirzepatide — are now widely prescribed for weight loss, with growing evidence they can also reduce the risk of heart disease and stroke.But in the United States, access to GLP-1 drugs often depends on insurance coverage — and on who can afford to pay.In this first episode of a three-part Business Daily series on the global weight-loss economy, Sam Fenwick examines the real cost of obesity drugs in the U.S. healthcare system.How much do GLP-1 medications like Ozempic, Wegovy, Zepbound and Mounjaro actually cost? Are they cost-effective in the long term? And can insurers and employers afford to provide them to millions of Americans living with obesity?If you'd like to get in touch with the team, our email address is businessdaily@bbc.co.ukProduced and presented by Sam Fenwick.Business Daily is the home of in-depth audio journalism devoted to the world of money and work. From small startup stories to big corporate takeovers, global economic shifts to trends in technology, we look at the key figures, ideas and events shaping business.Each episode is a 17-minute deep dive into a single topic, featuring expert analysis and the people at the heart of the story.Recent episodes explore the weight-loss drug revolution, the growth in AI, the cost of living, why bond markets are so powerful, China's property bubble, and Gen Z's experience of the current job market.We also feature in-depth interviews with company founders and some of the world's most prominent CEOs.These include Google's Sundar Pichai, Wikipedia founder Jimmy Wales, CEO of Canva Melanie Perkins, and the CEO of Starbucks, Brian Niccol.(Picture: Person standing on weighing scales. Credit: Press Association)

What does it mean to lead the fitness industry in 2026? In this Coach Confessional episode, CEO Amanda Tress is back with a personal update and a bold look at the future of the FASTer Way—from moving her family to Costa Rica to launching a massive overhaul of the FASTer Way Certification. Amanda and Pro Trainer Haven Hennessey dive deep into why the FASTer Way is officially the premier, most modern and robust fitness and nutrition certification on the market. FASTer Way is leading the charge providing what no other program does: cutting-edge curriculum on hormones, advanced custom macros, and the "elephant in the room": GLP-1s and peptides.  Amanda shares her personal, transparent journey with peptides and why she believes "human plus" technology is the only way to combat the rise of generic AI fitness apps. Whether you're a client looking for the "Midlife Edge" or a coach ready to lead, this episode is your roadmap for what's next. Join FASTer Way's next 6 Week Program: https://www.fasterwaytofatloss.com/ Don't forget to check out our merch, supplements and other great deals: https://fasterwayshop.com/ Subscribe: youtube.com/FASTerWaytoFatLoss Follow us on Instagram: Amanda Tress: https://www.instagram.com/amandatress Haven Hennessey: https://www.instagram.com/havenhenn/ FASTer Way to Fat Loss: https://www.instagram.com/fasterwaytofatloss  

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Pharma ads, biotech IPOs, $1M longevity programs, oh my!This month's Digital Health Download skews towards biotech, which is having a moment. Tune in to hear Halle and Michael cover the latest headlines.We cover:Why pharma ads are surging and the growing push for restrictions on D2C drug advertisingHims & Hers' $1.15B acquisition of Eucalyptus, its global expansion strategy, and the FDA crackdown on compounded GLP‑1 drugsThe return of biotech IPOs, with Eikon Therapeutics and Generate Biomedicines signaling investor interest in platform‑based drug discoveryVaccine makers scaling back research amid policy uncertainty, declining uptake, and tighter fundingTrumpRx's “most favored nation” drug pricing approach, and what one STAT analysis foundBryan Johnson's $1M per year “Immortals” longevity program—Show notes:Should drug companies be advertising to consumers? (The New York Times) Hims & Hers Enters $1.15 Billion Agreement to Acquire Eucalyptus (PharmExec.com)A sign biotech is back? Four drugmakers go public, raising nearly $1 billion in all (STAT)Vaccine Makers Curtail Research and Cut Jobs (The New York Times) TrumpRx claims to offer the lowest prices. But many drugs have cheaper generics (STAT)Bryan Johnson's Immortals: $1M to try longevity regimen (Axios) —"Halle Tecco wanted to see tech used for better medical services and getting people engaged in their own health. Now, she's written a book on how she went about it." - The WSJMassively Better Healthcare is out now!—Rock Health's annual CEO Summit is returning to the New York Stock Exchange on March 27th! Learn more and nominate a CEO to join this invite-only event here. —

Dr. Pamela Keel is Distinguished Research Professor in the Department of Psychology, Florida State University and the 2025-2026 Robert O. Lawton Distinguished Professor at Florida State University – the highest honor FSU faculty can award.  She directs the Eating Behaviors Research Clinic, co-directs the NIMH-funded Integrated Clinical Neuroscience Training Program, and leads efforts to enhance faculty recruitment and mentorship at Florida State University and has attracted over $55 million in external funding to FSU since joining their faculty in 2008. Her NIH-funded research examines the nosology, biology, epidemiology, and longitudinal course of eating disorders, and she has over 250 peer-reviewed journal articles and authored four books. Dr. Keel identified Purging Disorder as a new disorder of eating by revealing its clinically significant impact on the lives of those with the condition and demonstrating distinct postprandial gut peptide responses linked to purging in the absence of binge eating.  Her groundbreaking work contributed to Purging Disorder's inclusion in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Dr. Keel was honored with the AED Leadership Award in Research for the global impact of her work identifying Purging Disorder as a life-threatening illness affecting 1 in 50 women worldwide person does not.   We discuss topics including: Understanding the long-term outcome for bulimia nervosa (one person gets better and one person does not) Discussing what is weight suppression? Hormones including Leptin and Glucagon Peptide 1 (GLP-1) What happens when GLP-1 is released? What does lower leptin levels mean?   SHOW NOTES: https://www.cambridge.org/core/journals/psychological-medicine/article/test-of-a-biobehavioral-model-linking-weight-suppression-to-bingeeating-severity-via-leptin-and-glucagonlike-peptide-1-in-bulimia-nervosa-and-related-syndromes-in-women/C00119BEADF52EE75A53F7D675E9648A https://eatingbehaviorskee.wixsite.com/mysite https://www.cambridge.org/core/journals/psychological-medicine/article/test-of-a-biobehavioral-model-linking-weight-suppression-to-bingeeating-severity-via-leptin-and-glucagonlike-peptide-1-in-bulimia-nervosa-and-related-syndromes-in-women/C00119BEADF52EE75A53F7D675E9648A ___________________________________ If you have any questions regarding the topics discussed on this podcast, please reach out to Robyn directly via email: rlgrd@askaboutfood.com You can also connect with Robyn on social media by following her on Facebook, Instagram, Twitter, and LinkedIn. If you enjoyed this podcast, please leave a review on iTunes and subscribe. Visit Robyn's private practice website where you can subscribe to her free monthly insight newsletter, and receive your FREE GUIDE "Maximizing Your Time with Those Struggling with an Eating Disorder". Your Recovery Resource, Robyn's new online course for navigating your loved one's eating disorder, is available now! For more information on Robyn's book "The Eating Disorder Trap", please visit the Official "The Eating Disorder Trap" Website. "The Eating Disorder Trap" is also available for purchase on Amazon.

Sugar restriction during the first 1000 days of life may slash heart risk decades later; Are some people more genetically-adapted to the cold? While GLP-1 drugs may shrink muscle, new study confirms natural weight loss diets don't. Should strength assessments be added to routine physicals to forecast risk of dying? For gut health, take your microbiome for a run! Strontium safety and effectiveness; What are dietitians missing about GLP-1 drugs.

In this episode of the Flex Diet Podcast, I sit down with my good friend John Gorman to unpack the current “wild west” of peptides, TRT, GLP medications, and performance-driven bloodwork. We dig into how John's telemedicine clinic approaches comprehensive lab testing — and why running a full panel (including markers like reverse T3) matters far more than cherry-picking a few numbers. If you've been dieting hard, training consistently, and still feeling stuck, we break down how chronic stress, poor recovery, and subtle hormone disruptions can quietly crush metabolism and make fat loss feel like a white-knuckle grind. We also cover testosterone replacement therapy (TRT) — the real pros and cons, common oversimplifications in the industry, and what most clinics fail to discuss. From there, we dive into GLP-1 medications and tirzepatide, what we currently know, what we don't know about long-term use, and how to think critically about risk versus reward. John shares practical guidance on legitimate peptide sourcing, red flags to watch for, and how to think about “periphery” tools like methylene blue and injectable carnitine without getting sucked into hype. If you're interested in optimizing performance, improving body composition, or simply making smarter decisions in a rapidly changing medical landscape, this episode will help you separate signal from noise. Sponsors: Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:20 Johns Telemed Launch 05:15 How Lab Consults Work 08:23 Coaches and Bloodwork Ethics 13:25 Reverse T3 Explained 16:56 Stress Hormones and Dieting 20:08 Microdosing Tirzepatide 26:30 Long Term GLP1 Concerns 30:45 TRT Done Right 33:10 Better Clinics Better Consumers 35:56 Vetting Coaches and Clinics 37:40 Peptides Wild West 38:50 Spotting Bunk Peptides 41:22 Legit Sources and Protocols 42:30 Evidence vs Hype 45:17 How to Verify Quality 50:54 Which Peptides Matter 54:14 Methylene Blue and Carnitine 57:50 Dosing and Safety Notes 01:02:06 Wrap Up and Recommendations 01:04:03 Music Picks and Outro 01:07:07 Final Disclaimers  Flex Diet Podcasts you may enjoy: Episode 319: Exploring the World of Peptides with Anthony Castore YouTube: https://www.youtube.com/watch?v=RbTY6kRP1H4&t=11s Episode 212: The Pros and Cons of Training Elite Level Professional Athletes: An Interview with Dr. Andy Galpin YouTube: https://www.youtube.com/watch?v=rf1imcUu-Ew Connect with John: Instagram: https://www.instagram.com/team_gorman YoulTube: https://www.youtube.com/@TeamGormanPhysiqueEnhancement Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

Full Show Notes: bengreenfieldlife.com/hungercode On this episode, I got to geek out with Dr. Jason Fung and unravel why calorie counting alone doesn’t explain our weight struggles. Dr. Fung used jaw-dropping stats—like nearly identical calorie consumption between nations with wildly different obesity rates—to illustrate how hormones, digestion, and even the microbiome play a much bigger role than just numbers. We also broke down the three types of hunger—homeostatic, hedonic, and conditioned—and explored how ultra-processed foods hijack our biology. Dr. Fung shared that ditching those foods is his top strategy for conquering hunger, while I revealed how staying busy and using GLP-1s can help curb appetite during fasting or travel. Dr. Jason Fung is a physician (kidney specialist), researcher and New York Times best-selling author currently practicing in Toronto, Canada. trained in Los Angeles and Toronto and currently practices as a nephrologist (kidney specialist). His books, including The Obesity Code, The Complete Guide to Fasting, The Diabetes Code and The Cancer Code have challenged conventional thinking about these diseases, and introduces dietary strategies to manage them. Episode Sponsors: LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to lvluphealth.com/BGL and use code BEN15 for a special discount on their game-changing range of products. Truvaga: Balance your nervous system naturally with Truvaga's vagus nerve stimulator. Visit Truvaga.com/Greenfield and use code GREENFIELD30 to save $30 off any Truvaga device. Calm your mind, focus better, and recover faster in just two minutes. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Formula IQ: Recuperate IQ by Formula IQ is a comprehensive copper supplement designed to support mitochondrial energy, iron balance, and metabolic health by pairing bioavailable copper with essential cofactors your body needs for proper utilization, which is especially crucial if you've been under chronic stress or supplementing with high-dose zinc. Try it at formulaiq.com and use code BEN for 10% off.See omnystudio.com/listener for privacy information.

I am delighted to reconnect with Dr. Jason Fung today. He is a trained nephrologist and world-leading expert on intermittent fasting and metabolic health. He has authored multiple books, including the New York Times best-seller, The Obesity Code, The Diabetes Code, and, more recently, The Hunger Code.   In our conversation today, we unpack the obsessive focus on the calories-in, calories-out model, which is neither practical nor effective. We explore the root causes behind the narrow-minded thinking that calories alone drive obesity, differences between types of hunger and conditioned responses, how hormones affect other hormones, and lessons about GLP-1s. We examine the critical importance of fiber and protein, and offer clarity around carbohydrates. We also cover the impact of meal timing, sleep, and circadian biology, the fat thermostat and sympathetic tone, nutrition, stress, and mindful eating, and dive into the issue of ultra-processed foods. Join us for an insightful conversation that challenges conventional wisdom and offers a nuanced and sustainable approach to understanding hunger, metabolism, and long-term health. IN THIS EPISODE, YOU WILL LEARN: “Calories in, calories out” framework is technically correct, but practically useless How the homeostatic, hedonic, and conditioned hunger types differ Dr. Fung shares his take on GLP-1 medications How fiber stimulates natural GLP-1 production Processed and natural carbohydrates produce vastly different glucose and insulin responses. Avoid eating late-night meals! Complex relationship between hunger, hormonal regulation, and sleep quality Hormones that drive body fat regulation  How bitter foods suppress appetite and enhance satiety Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Jason Fung On his website Instagram and YouTube Dr. Fung's latest book, The Hunger Code, will come out in March. Pre-order on Amazon!

Jay Campbell—five-time international bestselling author, founder of BioLongevity Labs, and one of the original voices in the peptide world—is here to unpack what's really going on behind the GLP-1 explosion. Are these drugs miracle tools or misunderstood villains? And why are so many smart people still getting them wrong? We go way beyond the hype and fear, diving into microdosing, metabolic repair, thyroid changes, and why dosing may be the make-or-break factor. Could peptides actually rewire the brain, quiet food noise, and permanently improve metabolism? And what happens when midlife women use them strategically? We also explore what's next: oral GLP alternatives, mitochondrial peptides, body recomposition breakthroughs, and the controversial compounds no one's talking about publicly. Are we on the brink of eliminating obesity? And how do you use these tools without wrecking your receptors—or your health? In this episode, we uncover: How microdosing GLPS may improve metabolism long term. Why most people are dosing peptides completely wrong. What happens to thyroid function on GLP therapy. How peptides can rewire food addiction and cravings. Which next-generation compounds are changing body composition. Tune in and decide for yourself what's hype, what's fear, and what might truly change the future of midlife health!     Sponsors Get 20% off your Cozy Earth Bed Sheet with coupon code HORMONES Coupon KM20 to get 20% off your order of Vitali Skin Care!     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Send a textToday we're joined by Dr Max Pemberton and Dr Courtney Raspin, authors of The Weight Loss Prescription, to unpack one of the most talked-about health shifts of our time: GLP-1 weight-loss medications.Are they a miracle? A medical breakthrough? Or a shortcut that risks creating new problems?In this conversation we explore what happens when you remove someone's primary coping mechanism, food, and why anxiety, low mood or even addiction can surface if the psychological work isn't done alongside the medical treatment. We tackle the tension between body positivity and health reality, the stigma and secrecy around using weight-loss medication, and why midlife with its hormonal shifts, muscle loss and bone health concerns changes the equation entirely.Most importantly, this is a compassionate, non-judgemental discussion. It's an honest look at what these medications can - and can't - do, and how to approach weight loss with both medical insight and psychological support.Whether you're on the medication, considering it or just interesting in the impact of GLP1's beyond weight loss, you're not going to want to miss this.For more information: https://theweightlossprescription.com/IBIZA RETREAT, May 2026: https://themidlifementors.com/retreats/ Support the showPlease remember, if you find the show helpful or it makes you laugh, motivates and inspires you - please do like, share and rate us. We don't run ads on the podcast or for the show, because we want to keep it as enjoyable for you to listen as possible. So if you can help us spread the word, we'd be incredibly grateful.For more information about The Midlife Mentors, click the below link:https://linktr.ee/themidlifementors.comTik Tok: @themidlifementorsIG: @midlifementors

#945: Join us as we sit down with David Roberts & Dr. John Gildea – the scientists behind Mara Labs. After losing his wife to breast cancer, David founded Mara Labs on a mission to uncover what truly supports cellular detox, brain health, & longevity. Alongside him is Dr. Gildea, a molecular biologist with 60+ peer-reviewed studies & two decades of research on how targeted compounds protect cells, clear environmental toxins, optimize metabolism, & build resilience as we age. In this episode, they break down sulforaphane's anticancer potential, natural alternatives to GLP-1s, the truth about microplastics & hidden toxins, & what your detox protocol is likely missing.   To Watch the Show click HERE   For Detailed Show Notes visit TSCPODCAST.COM   To connect with Mara Labs click HERE   To connect with Lauryn Bosstick click HERE   To connect with Michael Bosstick click HERE   Read More on The Skinny Confidential HERE   Head to our ShopMy page HERE and LTK page HERE to find all of the products mentioned in each episode.   Get your burning questions featured on the show! Leave the Him & Her Show a voicemail at +1 (512) 537-7194.   This episode is sponsored by Mara Labs For the next week, Skinny Confidential listeners can get an exclusive 25% off at http://mara-labs.com/SKINNY using code SKINNY at checkout. This exclusive offer ends March 6th. After that, the discount will return to the standard 15% off. Produced by Dear Media

This week's stories: Sinclair's This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets. • Sources: – World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026 – NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair AlphaFold 4 in a locked box: DeepMind's private AI drug design engine Isomorphic Labs, DeepMind's drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs. • Sources: – Nature: https://www.nature.com/articles/d41586-026-00365-7 – Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier Peptides in the freezer: El Mencho's anti aging stash and the dark side of wellness After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides. • Sources: – New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/ – Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954 – Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM The disease we thought was dead: measles comes roaring back Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home. • Sources: – AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026 – ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078 – CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections DC vs your health: Trump's State of the Union health reset President Donald Trump's 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction. • Sources: – Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup – Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/ – This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/ All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update Thank you to our sponsors! Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 0:30 - Story #1: David Sinclair 2026 2:13 - Story #2: Google Drug Discovery 3:48 - Story #3: El Mencho Biohacking5:30 - Story #4: Measles Outbreak 6:51 - Story #5: Trump State of the Union 8:00 - Weekly Roundup 9:10 - Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A superb note on CPR and DNR orders, patients' vs doctors' preferences for statins, more on GLP-1s, another LAAC story, and some closing cautionary notes on PFA are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Addressing Inadequate Documentation of Unilateral DNR https://jamanetwork.com/journals/jama/fullarticle/2829203 Video: Can We Talk About CPR? https://www.youtube.com/watch?v=yTCRfY3ETvI Personal Reminiscences of CPR's Origin https://www.ajconline.org/article/S0002-9149(03)00977-9/pdf II Public Preferences for Statin Therapy Measuring Public Preferences for Statin Therapy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844660 III GLP-1 RA News ACHIEVE Trial https://doi.org/10.1016/S0140-6736(26)00202-3 IV New Trial in GLP-1 for Patients with AF Seminal-AF Trial https://clinicaltrials.gov/study/NCT06499857 V Relationship between Spontaneous Echo Contrast and LAAC Outcomes OCEAN-LAAC Trial https://doi.org/10.1016/j.jacep.2025.09.028 News Release on Upcoming LAAOS-4 trial  https://www.phri.ca/watchman/ Reading the "Smoke" -- Editorial on OCEAN-LAAC https://www.jacc.org/doi/10.1016/j.jacep.2025.10.029 VI Concluding Remarks on My Talk at Western AF Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.077983 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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February 27, 2026: Your daily rundown of health and wellness news, in under 5 minutes. Today's top stories: YOU(th) Health Tech raises $4.5M to expand smartphone-based health screening platform detecting 50+ digital biomarkers in under two minutes UFC Gym partners with NexGen MD Scientific to launch in-gym longevity clinics offering GLP-1s, peptides, and hormone replacement therapy XENOM raises $15M seed funding to launch "Decathlon of Fitness" with 10 standardized events, debuting at Dallas Cowboys facility in June More from Fitt: Fitt Insider breaks down the convergence of fitness, wellness, and healthcare — and what it means for business, culture, and capital. Subscribe to our newsletter → insider.fitt.co/subscribe Work with our recruiting firm → https://talent.fitt.co/ Follow us on Instagram → https://www.instagram.com/fittinsider/ Follow us on LinkedIn → linkedin.com/company/fittinsider Reach out → insider@fitt.co

In this Health, Wellth & Wisdom Podcast episode, host and Nutrition Coach Nicole Hagen breaks down the things you need to know about GLP-1 medications: what they actually do, who they're designed for, what realistic expectations should be, and why they are a powerful tool but not a replacement for healthy eating and movement habits.This episode explores the science behind GLP-1 medications, clears up common misconceptions, and answers the important question: What can coaching provide that GLP-1s can't? If you've been curious about these medications, are currently using one, or are wondering how they fit into a sustainable weight loss plan, this conversation will help you think critically and realistically about long-term success.Throughout this episode, you'll learn:What GLP-1 medications do in the body and how they support appetite regulationWho the research shows GLP-1 medications are most appropriate forWhat realistic expectations look like when it comes to long-term use vs. transitioning offWhy weight regain often happens after stopping What coaching provides that medication alone cannotIf you have questions about GLP-1's and want to approach weight loss in a way that prioritizes sustainability over quick fixes, this episode will help you understand how medication and habit-building work together to make it happen. Apply for 1:1 Nutrition Coaching:https://nutritioncoachingwithnicole.com/1-on-1-coachingCheck your HSA/FSA Eligibility:  https://app.truemed.com/qualify/tm_qual_q0c29x5n9v

What if the reason you’re not healing isn’t that you need another diagnosis? 0:08 It’s that your cells aren’t receiving the right signals. Because the body doesn’t run on diagnosis, it runs on 0:16 communication. And peptides are one of the most powerful, most misunderstood 0:21 tools we have for cellular signaling, immune balance, tissue repair, gut 0:27 lining support, metabolic control, brain signaling, sleep cycles, and even sexual 0:35 wellness. Today, I’m going to do what most people won’t. Define peptides in 0:41 plain English for you. break them into categories by what they’re best at and 0:47 tell you which ones are FDA approved on the list and which ones are commonly 0:53 used off label or investigational with the evidence that actually says these 1:00 work. This is going to be a powerful episode and if you’ve ever felt like you’re hearing hype without clarity, 1:07 this one’s for you. So, as usual, grab your cup of coffee or tea and settle in 1:13 as we talk about peptides that can fit into your healing journey. We’re going 1:19 to have a short word from our sponsor. You know, we got to do that. That’s how we stay on the air here. So, we will be 1:26 right back after this. Did you know sweating can literally heal your cells? 1:32I nfrared saunas don’t just relax you. They detox your body, balance hormones, 1:37 and boost mitochondrial energy. I’m obsessed with my health tech sauna. And 1:42 right now, you can save $500 with my code at healthtechalth.com/drmuthqen25. 1:54 All right, here we go, guys. I am excited to dive into peptides with you. 2:00 So understanding peptides is foundational, right? And I’ve been 2:06 studying peptides now for about nine years. Um, and I find that they are 2:13 incredible. Um, so I want to break down for you what peptides actually are, what 2:19 they do, and some of the top peptides that are available today, and how they 2:25 can be utilized. Because I think it’s really important. And I think it’s it’s there’s a lot of confusion out there about what these things actually are and 2:32 are they safe? Are they not? When do we use them? What’s the science behind them? So, we’re going to dive in and 2:38 we’re going to talk about all things peptides. So, let’s get ready here. Here we go. So, peptides are short chains of 2:45 amino acids and they typically range anywhere from 2 to 50 amino acids and 2:51 they’re linked by peptide bonds. So think of them as the superglue that holds the amino acids together. They sit 2:58 between the amino acids and they are full proteins in terms of their size and 3:04 their complex structure. And what makes peptides particularly interesting in 3:10 medicine is their role as signaling molecules. They’re essentially the 3:15 body’s text messages carrying specific instructions to cells and tissues. And 3:21 unlike our proteins which often serve as structural roles or act as enzymes, 3:28 peptides typically function as hormones, neurotransmitters and growth factors and 3:33 they bind to specific receptors on the cell’s surfaces or within the cells and 3:39 they trigger this effect. It’s like a cascade effect of a biochemical reaction 3:45 that ultimately changes the cellular behavior. So basically, it’s changing 3:50 the way the body’s cell structure acts. And this is why peptides can be so 3:56 incredibly powerful and therapeutic when you introduce the right peptide signal. 4:02 Now, you could theoretically redirect cellular processes toward healing, 4:07 towards metabolism, immune balance, tissue repair. Any of those things can 4:14 be manipulated to do a certain thing once we add the peptide. The challenge 4:19 in peptide medicine though lies in distinguishing between those peptides that have been rigorously studied, 4:26 proven safe and effective and approved by regulatory bodies like the FDA versus 4:31 those that exist in what we call the gray zone of a promising clinical data. 4:36 But they really lack human validation so far. And this distinction is critical because the presence of a plausible 4:43 mechanism does not guarantee safety or efficacy in living humans. So, this is 4:50 really important and we’re going to dive in and look at some of the research on all of these different peptides that are 4:56 available and I’m excited to say there’s some amazing peptides being studied right now that unfortunately are not 5:01 available. But I can’t wait to see them hit the market for us because it is going to be a gamecher as far as health 5:09 and longevity. So there is a quality control issue and there is a hidden 5:14 variable in peptide medicine with this and it’s one of the most underappreciated aspects of peptide 5:21 therapy particularly for non-FDA approved peptides. It’s quality control. 5:26 When we discuss pharmaceutical medicines, we take for granted that the pill contains what the label says. Not 5:32 always true depending on where it comes from. You guys, if you’ve heard my episodes before talk about how many of our medications are made in China and 5:41 have been contaminated with other things, you will realize that that is not always true. So, just because it has 5:48 the FDA stamp of approval on the medication, it still does not necessarily mean it’s safe and we still 5:54 need to do our homework on it. So, sorry for digressing on you guys, but you know, when we get a medication, we we 6:00 think that what the amount says is what is there, doesn’t have contaminants, it’s manufactured with good 6:06 manufacturing practices. You’ll see that listed as GMP on the bottle, and it’s been stored properly, it’s been 6:12 maintained stable, and with research peptides and compounded formulations, 6:17 none of this can be assumed. So, I will share a story with you. There was a gentleman that was purchasing these 6:24 peptides online from a research facility and um did not know that they were 6:30 coming from China and he was ordering a particular growth hormone peptide and 6:35 after a little while he had he had done fine for the few first few bottles. After a little while he started having 6:42 some complications. He started getting really irritable and angry and ragy and 6:47 he didn’t quite know what was going on. And so he decided to go get some testing done. He had some blood testing done and 6:53 his testosterone level was over 5,000. So for those of you who know what testosterone level should be for a guy, 7:00 they really shouldn’t be any higher than about 1,00200 would be absolute max that we’d want to see. Now he was taking 7:06 testosterone but not to that degree. And prior to adding this peptide, his 7:12 testosterone was very stable. What they ended up finding out was the peptide that he was getting, whoever was 7:18 manufacturing it added testosterone to the peptide. They felt like if if it had growth hormone, that was great, but if 7:25 it had growth hormone and tes testosterone, all the better. And he didn’t know that. And this is the 7:31 problem that we can have with peptides if you don’t source them properly. if you’re not working with somebody that 7:37 knows how to source them and can prove that they are what they say they are. Um, I’m sure there’s a whole bunch of 7:42 studies out there too of people getting these peptides and paying hundreds of thousands of dollars for them over their 7:48 lifetime and finding out they were nothing more than just sterile water. So, you really do need to be careful 7:53 with your quality control. Now, this kind of leads us right into the next topic that we’re going to talk about and that’s the manufacturing question, 8:00 right? The FDA approved peptides are manufactured in facilities subject to 8:05 the FDA inspection rules following our GMP regulations and these facilities 8:11 must validate their manufacturing process, demonstrate consistency batch to batch, test for purity and potency. 8:18 They need to test for bacterial endotoxins and sterility and they need to maintain detailed records. So, when a 8:25 pharmaceutical company submits a drug application, the FDA inspects the manufacturing facility as part of the 8:32 approval process. If you’re getting peptides from a different country, none of that is happening. And there are some 8:38 ways for us to determine if that is what you’re getting. Typically, the rule of thumb is if your peptides are coming 8:44 with a different colored top, every one of them has a different colored top. Those are typically being sourced out of 8:49 China. I wouldn’t say that’s 100% but that’s kind of the rule of thumb that people follow. So compoundingies these 8:56 are thearmacies that make our bio identical hormones. They can make medications in any dose or strength or 9:02 route. There are thousands of them in every not that not in every state but 9:08 there are thousands of them around the country right now. So these compoundingies are registered as 503A 9:15 facilities. They do traditional compounding for individual prescriptions, right? Like they can make 9:20 thyroid, they can make LDN, they can make estrogen. You can also have a 503b 9:27 facility, which is an outsourcing facility. And these companies produce larger batches of products. They’re they 9:34 have some oversight, but they’re less stringent than for FDA approved 9:40 manufacturers. And state boards of pharmacy regulate a 503A pharmacy. And 9:45 the FDA can inspect the 503b facility, but doesn’t preapprove any of their 9:52 compounding products. So, they can inspect it, but they don’t approve them. So, research chemicals and these 9:58 suppliers operate essentially with no oversight. They explicitly market products for research use only, not for 10:06 human consumption to avoid FDA regulation. If they put that on their 10:12 product, they don’t have to comply to what the FDA is saying. And there is no required manufacturing strategies or 10:19 standards, no required testing, no required sterility assurance, and no enforcement mechanisms if products are 10:26 mislabeled or contaminated. So basically, they don’t have the liability, but that doesn’t mean that 10:31 all of them are badies or bad suppliers. It just means they don’t have to comply 10:37 to the FDA rules. Now, there are many of these companies that I’ve seen and I’ve talked to that do do a lot of this. They 10:44 do test their product for sterility. They do test their product to make sure it is what it says it is. They don’t 10:51 have to, but they do. So, if you’re going to decide to use a company that 10:56 has research only, not for human consumption, at least ask for their 11:02 proof of testing so that you know that the product you’re getting is what it says it is and that it’s clean. Because 11:08 this is where we run into the problem is in purity. So in purity peptide 11:13 synthesis can produce not just the targeted peptide but also related 11:19 peptides with deletions, substitutions, truncations or truncations of amino 11:25 acids. Sorry. And this high performance liquid we call it uh chromatography can 11:30 separate these related impurities and quality and quantify the actual target 11:35 of the peptide content. So a certificate of analysis is what you want to ask these companies for. This shows the HPLC 11:44 the testing mechanism with greater than 95% or ideally 98% purity which 11:51 indicates a higher quality product. So this certificate of analysis can be fabricated may not represent the 11:57 specific batch being sold. It happens. We need to know not everybody is honest. Not everybody, you know, does what they 12:03 say and it does what’s right. But at least you at least they’re giving you something and you have some security. 12:10 and then choose a company that was referred to by someone else that has done some homework as well. In in 12:16 commercial research, there’s independent testing and they research peptides and this has been really shocking 12:23 variability that they’ve seen. Some products contain 50% or less of the 12:29 claimed peptide and some contained primarily degradation of the product or manufacturing impurities and some 12:36 contained bacterial endotoxins at levels that could cause fever and systemic 12:42 inflammation if it was truly injected. And I would also worry with some of those problems, you know, depending on 12:48 what impurity or bacterial endotoxin was there. If you’re using a product to boost your immune system and your immune 12:54 system is already compromised, these bacterial endotoxins can actually make you sicker instead of what you want it 13:02 to do, which is making you better. So, sterility is always an issue with anything that is manufactured, 13:08 especially things that we’re doing as an injection. Peptides are intended for injection. They must be sterile. They 13:16 must be kept safe. And pharmaceutical manufacturers conduct this sterility testing on every batch. 13:22 Compoundingarmacies should conduct sterility testing particularly for high-risisk compounded 13:28 sterile preparations and research chemical suppliers may or may not conduct any testing. So injecting 13:35 non-sterile material can cause local infections, abscesses at the injection 13:41 site and or if the bacteria enters the bloodstream could potentially be 13:46 life-threatening and you could have sepsis. Now, excuse me. We saw this 13:52 happen in a compounding pharmacy uh gosh, it’s probably been 10 years ago 13:57 now, I think. um they unfortunately had a strep uh contamination in their 14:03 product and they weren’t testing it. It was a large compounding pharmacy out of Florida and they were making products 14:08 that were being injected into the joints and um these people got very very sick 14:14 and some of them died and um some of them got very very injured by this uh 14:21 complication that happened. So it’s not like this doesn’t happen. It does, but it doesn’t happen often. And that’s what 14:28 we have to know about. And so, when we’re talking with you guys about storage and stability, it’s really 14:34 important to make sure you maintain your peptides well. So, many peptides are unstable at room temperature. They 14:41 require refrigeration or freezing. We tell everyone to make sure you’re refrigerating your peptides. That way, 14:48 there’s no question about it. when it stays cold um it prevents or slows down 14:54 the process of uh bacteria growing in it. So some of these peptides actually 14:59 degrade very rapidly in the solution and they must be reconstituted immediately before use and reconstitution of the 15:07 peptides really has limited stability often just days to weeks not months. So 15:13 improper storage, temperature, um changes during shipping or prolonged 15:19 storage of a reconstituted product can lead to degradation into inactivity or 15:25 potentially even a harmful breakdown of the product itself. So if you have a product that’s been sitting in your 15:30 refrigerator for a month or two months or 3 months or 6 months, just throw it away. It’s not going to be any good. 15:37 you’re not going to actually get the peptide and the uh potency that you’re looking for anyway out of it and the 15:44 potential of you introducing an endotoxin, a bacterial endotoxin is quite high at that point. So you just 15:50 really don’t want to take the risk, excuse me. So what practitioners, what 15:56 should we do and what should patients do? Well, for any peptide therapy, we 16:03 want to source our verification. know where the peptide product comes from. Is 16:08 it an FDA approved product? Is it a 503b compounding? A research chemical 16:14 supplier? Is there a certificate of analysis? Request and review this COA. 16:20 And you want it to show purity greater than 95% but ideally greater than 98%. 16:27 You want that identity be identity to be confirmed by mass spectromedy. Uh 16:33 sterility testing should be done. Bacterial endotoxin testing should be done. Batch number matching of the 16:39 product that you received should be done. Proper storage. You want to know that this has been refrigerated or 16:46 frozen as directed once it’s been mixed. Look at the expiration dates for reconstituting your peptides. Track that 16:53 reconstitution date and discarded accordingly like we just talked about. Monitor for your adverse effects. Even 17:01 with the perfect quality control, monitoring for adverse effects is essential with questionable quality and 17:08 vigilance is really critical here. I know it’s frustrating for a lot of patients when they have to get several 17:15 bottles and they only last a week or two. right here, you guys. This is why 17:21 they only last a short period of time because once they’re mixed, they start 17:26 to degrade and they won’t be good and you won’t get the benefit from it. So, 17:31 it’s really important with these research peptides specifically, practitioners should recognize that all 17:38 recommending products without quality assurance violates the fundamental medical principle of first do no harm. 17:45 If a patient is determined to use research peptides despite counseling, providing guidance on quality 17:52 verification, requesting those COAs, using pharmaceutical grade sources when available, proper testing, this all 17:59 reduces harm, but doesn’t constitute necessarily that recommendation. Now, 18:06 that being said, today it’s very difficult to find peptides by the compoundingies because of what the FDA 18:13 has done. So most of the peptides that are available to us have been labeled 18:18 not for human consumption, not because they’re not good products, but because 18:25 of what the FDA did. And this is how these companies have been able to 18:31 continue to provide peptides to the medical community. And if you know you 18:36 have a good company, then you’re, you know, you’re still taking the risk, right? But at the end of the day, the 18:42 reason they’re doing that is to protect themselves from the FDA, from liability. Um, so just kind of know that there is 18:50 some talk in the community with um Bobby Kennedy that this is going to change and 18:55 they are going to bring peptides back to the compounding pharmacies. Now, we don’t know which ones they’re going to 19:01 bring back. Uh, will it be all of them? Will it just be some of them? What’s going to happen here? Um, is it going to 19:07 go to the pharmaceutical companies like our GLP1s did? We don’t know what that’s going to look like quite yet. Um, but it 19:14 is coming and that is positive news. So, let’s talk now about FDA approved 19:21 peptide medications. So, this is the metabolic revolution, right? GLP1 19:28 and our dual increeting agonists. This is an exciting time. GLP-1s are amazing. 19:35 Um, a lot of people are skeptical, a lot of people love them, a lot of people hate them. Whichever side of the fence 19:42 that you’re on, I understand. But I want to talk about the science of it today 19:48 and what it actually means for people. So, the story of GLP1 glucagon like 19:54 peptide one represents one of the most significant advances in metabolic 19:59 medicine in the past several decades. GLP-1 is an accretin hormone. It’s 20:05 gutder derived peptide that potentiates insulin secretion in response to food 20:11 intake. And the body naturally produces GLP-1 in the intestinal L cells, but it 20:17 rapidly degraded by the enzyme DPP4 giving it a halflife of only about 2 20:24 minutes. So this rapid breakdown made in therapeutically impractical until 20:31 research was developed and modified the analoges that resist the enzyme degradation. So for those people who 20:39 never feel full when they’re eating, never feel satisfied when they’re done, this is because their body is either not 20:46 producing enough GLP1 or it’s not getting the signal right. And this is a 20:51 leptin issue. This is an insulin issue. It’s a GLP-1 issue. It’s a complicated 20:56 issue. This is not anything that the person is doing wrong. It’s what is happening to their body. And so GLP1s 21:03 have really revolutionized this. So one particular GLP-1 that we have is 21:09 semiglutide. And this GLP-1 agonist is what changed everything in the world of 21:16 metabolic medicine. Semiglutide is marketed as ompic for type 2 diabetes 21:23 and it’s marketed as WGOI for chronic weight management. It is a modified 21:29 GLP-1 analog with 95 or sorry 94% amino acid sequence uh homology to human 21:37 GLP-1. So it means that it’s it’s just like our own GLP-1 that we make. This 21:42 modification includes specific amino acid substitutions and the addition of C18 21:50 a fatty acid chain which allows the peptide to bind to albumin. Now this 21:56 albumin binding dramatically extends the half-life to approximately one week 22:01 enabling one weekly dosing which is a major advantage over the earlier GLP-1 22:07 agonists that require daily or twice daily injections. The mechanism by which 22:13 semiglutide works is multiaceted. At the pancreatin level, it binds to GLP-1 22:20 receptors on the pancreatic beta cells enhancing glucose depending sorry 22:27 enhancing glucose dependent insulin secretion. This glucose dependency is 22:33 crucial. It means the peptide only stimulates insulin release when blood glucose is elevated. This dramatically 22:41 reduces the hypoglycemic risk compared to insulin or even uh sulfuras. 22:47 Simultaneously semiglutide suppresses glucagon secretion from pancreatic alpha 22:53 cells further improving glycemic control. This is really amazing because 23:00 over the years when we’ve used insulin, which is also a peptide by the way, you 23:05 had to dose it just right because if you didn’t, you would produce so much insulin that it would crash the blood 23:12 sugar and then somebody would have too low of a blood sugar. They’d be hypoglycemic and they’d have to eat more 23:18 sugar and then they’d have to modify the insulin again and the person would be going up and down, up and down, up and 23:24 down all day long. And that created a lot of problems for people and so this 23:30 helps to stabilize that so it is not such an intense change. Now in the GI 23:36 tract semiglutide delays the gastric emptying particularly pronounced during 23:41 the initial weeks of therapy. This slowing of the gastric emptying contributes to the sensation of being 23:48 full and early satiety that patients often describe. However, this effect 23:54 tends to attend to weight over time as the body adapts through the appetite 24:00 suppressing effects generally persist through central mechanisms. So, when we 24:05 talk about what is actually happening, we’re slowing that digestive process down. That’s why people aren’t so 24:11 hungry. It’s why they’re not eating so much. This is why people can develop constipation with these products because 24:17 it’s slowing the body’s digestive tract down. Now some people will call this 24:22 gastroparesis. Um gastroparesis is actually different. 24:28 It is when we lose control over what’s happening in the in the colon like the 24:34 nerves and things like that just stop working. I have never seen that with the GLP1s that we prescribe in micro doing. 24:42 um it’s been documented. It can happen, but again it a lot of it is dosing and a 24:48 lot of it is staying on top of your client and what’s happening and what’s going on and what you’re doing and making sure that they do have good 24:54 motility still. So a lot of these things can be mitigated if you have problems 24:59 with them. Now one of the most profound effects of semiglutide occur in the 25:05 central nervous system. GLP-1 receptors are widely distributed in the brain 25:10 particularly in the hypothalamus and the brain stem area where we are involved in 25:15 appetite regulation. So when when wilding and colleagues published their 25:20 landmark step one trial in the New England Journal of Medicine in 2021, 25:25 they demonstrated that participants receiving 2.4 4 milligrams of semiglutide weekly achieved an average 25:32 weight loss of 14.9% of their body weight over 68 weeks. Now, I want you 25:39 guys to really understand this. We’re talking roughly 15% body weight loss 25:45 over a year, longer than a year. 52 weeks is a year, right? This is 68 25:50 weeks. So, it took longer for them to lose. We’re not talking about giving 25:55 somebody a dose to lose 15% of their body mass in a month or two. That that 26:01 is not healthy for any of us. That is not what we’re talking about doing here. Now, they compared this to placebo and 26:08 the placebo was only 2.4%. So, that is a significant difference. 26:14 And even beyond the numbers, patients reported something very qualitatively different, a reduction in what’s now 26:21 called food noise. Everybody knows what food noise is. We’ve talked about this long before GLP1. It’s that craving. 26:28 It’s that part of your brain that just keeps thinking about I want to eat something. You know, that was actually 26:34 reduced and they didn’t expect to see that happen. Now, this refers to the constant mental preoccupation with food, 26:42 the intrusive thoughts about eating, the difficulty in feeling satisfied. Semi-glutide appears to appears to 26:49 modulate reward pathways in the misolyic system reducing hedonic eating and food 26:57 cravings. Now there are also great cardiovascular effects of semiglutide 27:02 that extend beyond weight loss. Uh the sustained six and select trials 27:07 demonstrated significant reductions in major adverse cardiovascular events uh 27:14 mace in high-risisk populations. The select trial published in 2023 showed 27:20 that semiglutide reduced cardiovascular death, non-fatal myioardial inffection 27:25 and non-fatal stroke by 20% in adults with overweight or obesity and 27:31 established cardiovascular disease but without diabetes. So this suggests that 27:37 mechanisms beyond glucose control and weight loss possibly including 27:42 anti-inflammatory effects, improvements in endothelial function and favorable 27:47 changes to lipid profiles. Now I will tell you the clients that I work with that are on GLP1, 27:53 they will tell you that their inflammation has been significantly reduced. We are also seeing really 28:00 amazing results in lipid profiles. um part of its weight loss, but there is a 28:06 component to this that is lowering the triglyceride levels because it’s related to sugar and how the body’s processing 28:11 it. And we’re seeing better profiles, less need for statins as a result of 28:17 that. If if you want to listen to my episode on statins, I have one on that. Uh they are not my favorite medication. 28:24 I think it’s overprescribed and overused um and not really affecting or 28:29 addressing the problem. So these things can really be helpful. There’s also some 28:34 uh ramblings going on with GLP-1s saying that they may be able to help with 28:40 addiction in the future because of where they’re finding it affecting the brain and how it affects the food noise and 28:47 the cravings that we have for food and the addiction for food. Could it potentially help with other addictions 28:53 down the road? We’ll have to wait and see on that one. So semiglutide’s FDA prescribing information also includes a 29:00 box uh boxed warning about thyroid sea cell tumors. So in rodent studies 29:06 semiglutide caused dose dependent and treatment duration dependent sea cell 29:12 tumors at clinically relevant exposures. So while it’s unknown whether or not 29:17 semiglutide causes uh thyroid cancer tumors in humans and the rodent thyroid biology 29:26 differs significantly from humans, the drug is contraindicated in patients with a personal or family history of 29:33 medillary thyroid carcinoma or in patients with multiple endocrine neopl neoplasia syndrome type two. it is 29:42 uh contraindicated for safety effects with that. Um I have seen endocrinologists okay GLP1s to be used 29:50 in patients who’ve had other forms of thyroid cancer just not the meillary 29:55 thyroid cancer. So there is possibility there. Now the most common side effects 30:00 are gastrointestinal. It’s nausea affects about 20 to 44% of patients 30:06 depending on the formulation with diarrhea, vomiting, constipation, abdominal pain, and also frequently 30:13 reported in clinical trials. I see this in my clinic, too, especially dose dependent. Um, and it happens early on 30:20 when you’re first starting the medication, but seems to settle out over time. The one that I would add to this 30:26 that I don’t think they have on here is an increase in acid reflux. We also see that quite often uh especially in people 30:33 who suffer with acid reflux to begin with. Now these effects are typically most 30:40 pronounced during the escalation and they like I said often improve over time 30:45 but more serious but less common adverse effects include acute pancreatitis. 30:51 The medication needs to be discontinued immediately if this is confirmed. You can see some diabetic retinopathy 30:57 complications in patients with pre-existing retinopathy and acute kidney injury. Um, this usually happens 31:05 secondarily to dehydration from the GI effects. There are some gallbladder disease um that can occur and people who 31:13 have a sensitive gallbladder will describe uh discomfort with that. I’ve 31:18 even seen some people who’ve had their gallbladder out on GLP1s at the higher doses complain of similar pain that they 31:25 used to have when their gallbladder was in. So, really important to just kind of monitor these symptoms and work closely 31:32 with somebody that understands them and can be on top of them quite quickly if this happens. Excuse me. From an 31:39 integrative medicine perspective, semiglutide really represents a powerful tool, but it’s not a standalone 31:46 solution. Remember, the medication addresses one aspect of the metabolic dysfunction, the signaling systems 31:53 controlling appetite and glucose homeostasis, but it doesn’t address the root cause that led to the metabolic 32:00 disease in the first place. Patients who rely solely on the medication without addressing the ultrarocessed food 32:07 consumption, the ccadian disruptions, the chronic stress, the sleep apnea, or 32:12 underlying hormonal imbalances often experience weight regain when the medication is discontinued. 32:20 The drug is also not a substitute for addressing the emotional and psychological drivers of eating 32:26 behavior, including the unresolved trauma that may manifest as emotional eating. I think this is really important 32:33 because we don’t address the trauma issue enough with clients and we need to 32:38 be looking at that. There is a huge trauma effect out there these days that is I don’t want to say leading to or 32:45 causing but it is definitely contributing to chronic illness and it’s not being talked about enough. So we 32:52 really need to be talking about this and addressing this trauma aspect. Now the next GLP that one that I want to talk 32:59 about is trespathide. This is a dual agonist. It takes center stage. It is my 33:05 favorite GLP one. Trisepatide is marketed as Mangjaro for type 2 diabetes 33:11 and Zepbound for chronic weight management and it represents the next 33:16 evolution in increantbased therapy. This is a dual agonist a 39 amino acid 33:23 synthetic peptide structurally based on the human glucose dependent insulin tropic peptide so GIP sequence but 33:31 modified to activate both the GIP receptors and the GLP1 receptors. So the 33:37 addition of the GI GIP agonism to the GLP1 agonism appears to create this 33:46 synergistic effect that goes beyond simply adding the two mechanisms together. So the GIP like GLP-1 is an 33:55 increant hormone secreted by what is called the K cells in response to nutrient intake. It enhances glucose 34:02 dependent insulin secretion but it also effects on atapost tissue metabolism 34:09 potentially improving the insulin sensitivity in fat cells and influencing 34:14 how the body stores and metabolizes fat. So some research suggests that GIP may 34:20 also have effects on energy expenditure though this remains an area of 34:26 investigation. So basically what we’re saying is this drug may actually help 34:32 people who are insulin resistant or insulin sensitive, not just somebody who 34:38 has problems with glucose control. So, this is super exciting because it opens 34:43 up the door for all of these people for decades that we’ve been trying to manage with insulin resistance and trying to 34:50 prevent diabetes and honestly most of the time have been unsuccessful 34:56 unless you can keep your diet at 50 grams of carbs or less a day, which is extremely difficult. Um, and take some 35:04 supplements that may or may not work and or take some metformin that may or may not help. this drug actually really 35:11opens that up and helps in that capacity. So there was a clinical trial 35:17 called the surmount clinical trial which demonstrated that trespathide produces 35:22 even more substantial weight loss than semiglutide. In the surerount one trial published by uh J tree I might have said 35:31 that wrong. I apologize if I slaughtered your name and colleagues in the New York England Journal of Medicine in 2022. 35:38 Participants receiving the highest dose of trespide, which is 15 milligrams, achieved an average weight loss of 20.9% 35:47 of their body weight over 72 weeks, compared to 3.1% with placebo. This 35:54 level of weight loss approaches what’s typically only seen in beriatric surgery. So, this is amazing because if 36:02 this medication works and we don’t have to do beriatric surgery, stomach stapling basically, um, oh my gosh, it’s 36:11 amazing. There are so many complications and risks that go with stomach stapling and the different procedures that they 36:17 do these days. People don’t absorb their nutrients properly. They have to do liquid nutrients. It’s very complicated. 36:24 It’s very challenging. Many of these people gain their weight back. Um, and 36:30 this procedure is not fun to go through. So, if we could change that and change 36:35 the lives of people who’ve really been struggling, it is amazing. And I will tell you that I have seen this work. I 36:42 have seen people lose 100 150 pounds on these medications over a year or two 36:50 period of time. It is definitely slower than beriatric surgery on some standpoints, but that is okay. You don’t 36:56 want that rapid weight loss. It’s not good for you. It’s not healthy for you. It doesn’t look well. You know, we want 37:03 to do this safely and effectively in the best way that we can possibly do that for you. Now, the adverse effect profile 37:10 is similar to semiglutide. It’s dominated by gastrointestinal effects. 37:15 Nausea, diarrhea, decreased appetite, vomiting, constipation. These were all commonly reported in the surmount 37:22 trials. And like semiglutide, tricepide carries a blackbox warning regarding the 37:27 thyroid sea cell tumors based on the rodent data and it shares the same contra indications in patients with a 37:34 family history of thyroid cancer and men too. So the mechanism behind why 37:40 tepatide often produces more substantial weight loss than GLP-1. The agonism 37:45 alone remains under investigation, but it may relate to the complimentary effects on the different aspects of 37:51 energy homeostasis or to GIP’s effects on atapost tissue and potentially on 37:58 central central nervous system pathways that GLP1 alone doesn’t fully address. 38:03 Now patients often report even more profound reductions in food noise with tricepide compared to GLP1 and uh sorry 38:12 GLP1 the agonists through this is anecdotal and hasn’t been regularly 38:17 quantified in quality studies. So I’ve done both uh personally and in my 38:22 practice. I really like trespide better than semiglutide. For me I had too many side effects with semiglutide. uh I had 38:30 less side effects with trespathide. I also plateaued on semiglutide which I 38:35 didn’t really care for. And with Tresepide, I haven’t plateaued and I’ve been able 38:42 to lose about 25 pounds in um a year and a half and I’ve been able to maintain 38:49 that. Um and I continued to use it because I do have a strong family history of cardiovascular disease. And 38:56 if this could help me so that I don’t follow my family lineage with cardiovascular disease, I am all for 39:03 trying to do that. I’ve watched too many of my family members suffer from this. I’ve lost my dad at a very young age. I 39:09 lost my grandfather at a young age to it. All of their brothers to this. And I don’t want to be that same person. So 39:16 that is why I chose to do that. And I think it’s really important for us to take a look at that and understand that. 39:24 Now, I know this has been a really long podcast and I don’t typically do podcasts this long. I have a whole host 39:31 of information on additional peptides. So, I’m going to break this up for you 39:36 guys and I’m going to do another episode and we’re going to pick up where we left off here with these peptides so that we 39:43 can actually start to dive into different peptides as well. So, check 39:48 out my next podcast show when we’re going to dive into the peptides that 39:54 talk about sexual wellness, immune function, and all the other cool things 39:59 that we can do with peptides. So until then, remember to like, share, and 40:04 subscribe. It really helps us get out to other people and share our information, 40:10 and join us for our next episode as we continue the talk about peptides. 40:15 Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and 40:21 information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its 40:28 management, or our partners. Each affiliate, sponsor, and partner is an 40:34 independent entity with its own perspectives. Today’s content is provided forformational and educational 40:40 purposes only and should not be considered specific advice, whether financial, medical, or legal. While we 40:48 strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique 40:56 circumstances. We encourage you to consult with a qualified professional to address your 41:01 individual needs. Your use of information from this broadcast is entirely at your own risk. By continuing 41:08 to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its 41:14 associates harmless from any claims or damages arising from the use of this 41:20 content. We may update this disclaimer at any time and changes will take effect 41:26 immediately upon posting or broadcast. Thank you for tuning in. We hope you 41:31 find this episode both insightful and thought-provoking. Listener discretion 41:36 is advised.The post Episode 256 – How Peptides Work, Benefits, and FDA-Approved vs Off-Label Use Explained first appeared on Let's Talk Wellness Now.

Justin talks to Michael P. Brady, Administrator for the Laborers' Local 157 Benefit Funds in Schenectady, NY about his fund's journey in covering GLP-1 drugs for weight loss and what other organizations can learn from his experience. Micheal is also a long-time member and volunteer with the International Foundation. He has served on the Health Care Management Committee and has spoken at many IFEBP conferences.

This issue will review: 1.     Real-World Prospective Validation and Economic Evaluation of Deep Learning-based Diabetic Retinopathy Detection from Fundus Photographs: A Systematic Review and Meta- Analysis 2.     Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial 3.     FDA removal of SI for GLP-1s – FDA Announcement Neil Read/John Comment 4.     Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk: A Target Trial Emulation Study 5.     GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients with Type 2 Diabetes or Cardiometabolic Diseases: A Meta-Analysis of Randomized Controlled Trials  Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. For more information about each of ADA's science and medical journals, please visit Diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health

With dangerous medical advice taking over social media, peptides are bleeding from niche biohacking and "gym bro" communities into the mainstream. This week, Chloe breaks down the science, the risks, and why the "magic medicine" mindset around unauthorised injectables is dangerous. In this episode Chloe covers: What Peptides Actually Are: Short chains of amino acids that act as signaling molecules (like insulin and GLP-1) to tell your cells what to do. Approved Peptides: A look at legal, heavily tested peptides (like GLP-1s and Insulin) and why their knock-on metabolic effects require strict medical supervision. Unapproved & Unproven Peptides: The massive risks behind unauthorized, internet-bought compounds like BPC-157 and TB-500, including a harrowing case study. Inherently Risky Peptides: Debunking the muscle-growth myths around IGF-1 and Growth Hormone Secretagogues, and exposing their severe cardiovascular and insulin resistance risks. The Bottom Line: Why you should always steer clear of unauthorized injectables, plus a recommendation to check out the Barbell Medicine podcast for a deeper dive into the clinical science. Don't forget to like, subscribe, rate, and review the Bodcast! It helps others find the podcast more easily. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Zack Peter is here! We theorize on Savanah Guthrie's 1 million reward and what it means for the case. We share our predictions for the Traitors' finale. RHSLC Whitney Rose got buzzed at a live show. Should she be rewarded or punished? ANTM scoop keeps coming. Crystal Hefner is protecting women. Ghislaine Maxwell had a billionaire boyfriend after Epstein. Britney is back. So juicy. Enjoy -Refresh your wardrobe with Quince. Go to ⁠https://quince.com/juicy⁠ for free shipping on your order and 365-day returns. Now available in Canada, too.  -Go to ⁠https://RO.CO/JUICYSCOOP⁠ to see if you're eligible for the new GLP-1 pill on Ro. -Sign up for your one-dollar-per-month trial today at ⁠https://SHOPIFY.COM/juicy⁠  -Get a free can of OLIPOP. Buy any 2 cans of Olipop in store, and we'll pay you back for one. Works on any flavor, any retailer. Go to ⁠⁠⁠⁠https://drinkolipop.com/juicyscoop⁠ -For a limited time, Nutrafol is offering our listeners $10 off your first month's subscription and free shipping when you visit ⁠https://Nutrafol.com⁠ and enter promo code JUICYSCOOP Subscribe to my new show Juicy Crimes!: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/juicycrimes⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Stand Up Tickets and info: ⁠⁠https://heathermcdonald.net⁠⁠ Subscribe to Juicy Scoop with Heather McDonald and get extra juice on Patreon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/JuicyScoopPod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/juicyscoop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Watch the Juicy Scoop On YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@JuicyScoop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Shop Juicy Scoop Merch: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://juicyscoopshop.com/⁠⁠ Follow Me on Social Media: Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/heathermcdonald⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@heathermcdonald⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@HeatherMcDonaldOfficial⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

The State of Hormone & Peptide Industry with Phil Vela Disrupting the health & wellness industry. (2:15) "It's that hard to do IT, so it's that easy to succeed once you've done IT." (2:48) What he did before he started Vita Bella, and the origins of the company. (5:00) The most applicable skills gained from his previous career. (7:41) Calling out the 'Grey Market' and its competition. (9:44) The state of the peptide industry and the fallout with Transcend. (15:54) Results & service. (25:23) Breaking down the Vita Bella membership package. (30:07) Businessman at heart. (33:34) Why he believes it should be illegal to prescribe GLP-1s by themselves. (35:13) Bad actors giving bad guidance. (43:33) His outlook for the future of the industry. (45:14) Will Ozempic and Tirzepatide ultimately bankrupt the United States? (53:27) The importance and value of having a trainer while on a GLP-1. (56:47) "I didn't build this business for money. I built it for a legacy!" (59:07) "Newer" peptides that have been impressed by. (1:03:16) Rapid fire: The best peptide for… (1:11:56) Related Links/Products Mentioned Visit Vita Bella for an exclusive offer for Mind Pump listeners! ** The first 50 signups will get a Vita Bella welcome box. You can finally achieve a top 1% all-around health at an affordable price! ** Get 20% off Kion at getkion.com/mindpump ** No code needed automatically applied at check out! ** MAPS Great 8 Launch - (Retail $127, Code: LAUNCH for 50% off!) ** Launch bonus include: MAPS GREAT 8 Nutrition Guide. ** Visit: http://mapsgreat8.com/  Mind Pump Store Mind Pump Hormones Facebook Private Forum GLP-1 Litigation: Compounder Sues Eli Lilly, Novo Nordisk Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Federal Court Tosses Lilly's Suit Against Strive Pharmacy: Jurisdiction Still Matters Mind Pump #2125: Heal Like Wolverine: BPC 157 with Dr. William Seeds Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Phil Vella – "Philly" (@phillyvz) Instagram Jay Campbell (@jaycampbell333) Instagram Rick Niemi (@gods.economy) Instagram Dr. William Seeds (@williamseedsmd) Instagram Peter Attia, M.D. (@peterattiamd) Instagram    

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You'll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what's new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You'll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors! • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources: • Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:22 – Introduction to Peptides 7:52 – Peptide Delivery Systems & Pens 14:22 – Safety & Regulation of Peptides 19:22 – SS-31 & Mitochondrial Health 26:22 – Blending Peptides & Cross-Linking 38:22 – Growth Hormone Peptides 44:22 – FLGR-242: The New Myostatin Inhibitor 54:22 – Melanin & Consciousness 57:22 – Klotho: The Longevity Peptide 59:25 – Regulatory Landscape & Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Now that the Winter Olympics have wrapped up, the Milan Cortina Paralympic Games kick off on March 6. Dozens of athletes will represent Team USA in sled hockey, skiing, wheelchair curling, and snowboarding. But getting to the Olympics or Paralympics is expensive and costs competitors an average of $12,000 a year. For winter athletes in particular, the costs can be even higher. But first: why the FDA is looking to put the brakes on compounded GLP-1s.

Now that the Winter Olympics have wrapped up, the Milan Cortina Paralympic Games kick off on March 6. Dozens of athletes will represent Team USA in sled hockey, skiing, wheelchair curling, and snowboarding. But getting to the Olympics or Paralympics is expensive and costs competitors an average of $12,000 a year. For winter athletes in particular, the costs can be even higher. But first: why the FDA is looking to put the brakes on compounded GLP-1s.

The episode then turns reflective as Mo’Nique urges fans to rethink the rising trend of GLP‑1 weight‑loss drugs. In an emotional message, she questions their long‑term effects, warns that celebrity-driven hype can push people toward unhealthy choices, and encourages listeners—especially young ones—to “love yourself enough” to trust the process rather than rely on quick fixes.See omnystudio.com/listener for privacy information.

This episode kicks off with dramatic global headlines, celebrity chaos, and major reality‑TV shakeups. The team breaks down the deadly confrontation between a Florida‑registered speedboat and the Cuban Coast Guard, a shootout that left four people dead and six injured. Cuban authorities allege the boat’s occupants—armed Cuban nationals living in the U.S.—opened fire first and were attempting a “terrorist infiltration,” prompting an international investigation and heightened political tension. The crew then dives into the explosive report that Cardi B allegedly flipped out backstage at SNL, destroying equipment after overhearing a joke referencing Nicki Minaj’s MAGA affiliation during rehearsals for the show’s 1,000th episode. Though the joke never aired, outlets report she threw her phone, punched a screen, and threatened to walk out before performing. Reality‑TV fans get big news as Pinky Cole and K. Michelle officially join The Real Housewives of Atlanta for Season 17, with Bravo signaling a major franchise reset. Cole enters with her Slutty Vegan empire storyline, while K. Michelle brings music‑industry pressure, a bold personality, and a shift into country music—all expected to shake up the cast dynamic. The episode then turns reflective as Mo’Nique urges fans to rethink the rising trend of GLP‑1 weight‑loss drugs. In an emotional message, she questions their long‑term effects, warns that celebrity-driven hype can push people toward unhealthy choices, and encourages listeners—especially young ones—to “love yourself enough” to trust the process rather than rely on quick fixes. Website: https://www.urban1podcasts.com/rickey-smiley-morning-show See omnystudio.com/listener for privacy information.

Can you eat plant-based and still avoid sugar, carbs, and ultra-processed foods? In this episode of Food Junkies, Dr. Vera Tarman is joined by Adina Mullen, plant-based chef, author of Vegan Flavors of the World, and founder of Adina's Delicacies, to explore whether vegetarian or vegan eating can truly support food addiction recovery, low-sugar living, and even plant-based keto—without deprivation or rebound eating. Adina brings a deeply grounded, real-world approach to plant-based cooking rooted in whole foods, cultural traditions, flavor, and satisfaction. This conversation goes beyond diet rules to focus on nourishment, satiety, and sustainability, especially for people healing their relationship with food.

February 26, 2026: Your daily rundown of health and wellness news, in under 5 minutes. Today's top stories: Gallup survey finds 73% of Americans turn to doctors first for health advice, with just 16% using AI tools and social media Alcohol industry erases $830B in market value since 2021 as GLP-1 drugs and structural demand shift drive U.S. drinking rates to lowest since 1939 Two-thirds of exercisers have tried AI fitness platforms, but only 10% would choose AI-only coaching as platforms shift to hybrid models More from Fitt: Fitt Insider breaks down the convergence of fitness, wellness, and healthcare — and what it means for business, culture, and capital. Subscribe to our newsletter → insider.fitt.co/subscribe Work with our recruiting firm → https://talent.fitt.co/ Follow us on Instagram → https://www.instagram.com/fittinsider/ Follow us on LinkedIn → linkedin.com/company/fittinsider Reach out → insider@fitt.co

You guys have been asking about peptides… and today we're finally breaking it down.In this episode, I sit down with Dr. Zarrabi from Vitality Med Spa in LA to talk about GLP-1 medications, semaglutide, retatrutide, BPC-157, TB-500, and the growing peptide trend taking over social media.Are peptides safe?Should you use them before plastic surgery?What does “stacking” actually mean?Is this FDA approved… or is it the Wild West?We cover:• GLP-1 medications for weight loss (Ozempic-style drugs)• Microdosing and biohacking• Compounding pharmacies vs brand-name pens• Certificate of analysis & quality control• Peptides for healing and recovery• The potential risks nobody talks about• Why you need to check credentials before injecting anythingIf you're a woman in your 30s prepping for surgery and thinking about losing 15–20 pounds first… this episode is for you.As always, we're not here to sell you hype. We're here to give you clarity.FOLLOW THE CONVERSATION

Mark Manson is the bestselling author of The Subtle Art of Not Giving a Fck* and Everything Is Fcked*, and host of The Mark Manson Podcast. He joins me for a powerful conversation that completely reframes confidence, purpose, and people pleasing.We unpack why modern confidence is so misunderstood, and how many of us are accidentally undermining it by chasing validation, praise and external accolades. Mark breaks down his actual formula for confidence: what truly builds it, what quietly erodes it and why you can't “affirmation” your way into feeling secure.We talk about the psychology at the core of people pleasing, why fear of rejection runs so deep and how to set personal rules that create strong boundaries without constant anxiety about disappointing others. We also get into how to properly audit your life, the problem with self-diagnosing in the age of TikTok therapy and why self awareness alone isn't enough.Finally, we dismantle the myths around purpose--why most people are searching for it in the wrong way--and the three components that actually create a meaningful life.If you've ever struggled with people pleasing, outsourced your worth, or felt pressure to “find your purpose,” this episode will give you a much more grounded, practical framework for becoming genuinely confident.This episode is brought to you by:Save 15% off my favorite Red Light Mask from BON CHARGE by using code BLONDE at www.boncharge.com.If you want clearer insight into your health, go to ForHers.com and schedule your labs today.Use code WELL and save 20% on your first order at https://justthrivehealth.com/WELL.Go to ro.co/blonde to see if you're eligible for the new GLP-1 pill on ro.Head to paleovalley.com/well or use code well at checkout for 15% off your first purchase. Visit ButcherBox.com/WELL for $20 off plus free shipping.This episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Produced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My Cousin Charlie McAvoy took home the gold with the USA hockey team! Inside Epstein's plane and Prince Andrew's arrest. Then I talked to former Real Housewife of Vancouver Mary Zilba about life on reality TV and if she'd do it again. -Refresh your wardrobe with Quince. Go to https://quince.com/juicy for free shipping on your order and 365-day returns. Now available in Canada, too.  -Go to https://RO.CO/JUICYSCOOP to see if you're eligible for the new GLP-1 pill on Ro. -Sign up for your one-dollar-per-month trial today at https://SHOPIFY.COM/juicy  -Get a free can of OLIPOP. Buy any 2 cans of Olipop in store, and we'll pay you back for one. Works on any flavor, any retailer. Go to ⁠⁠⁠https://drinkolipop.com/juicyscoop -For a limited time, Nutrafol is offering our listeners $10 off your first month's subscription and free shipping when you visit https://Nutrafol.com and enter promo code JUICYSCOOP Subscribe to my new show Juicy Crimes!: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/juicycrimes⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Stand Up Tickets and info: ⁠https://heathermcdonald.net⁠ Subscribe to Juicy Scoop with Heather McDonald and get extra juice on Patreon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/JuicyScoopPod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/juicyscoop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Watch the Juicy Scoop On YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@JuicyScoop⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Shop Juicy Scoop Merch: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://juicyscoopshop.com/⁠ Follow Me on Social Media: Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/heathermcdonald⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@heathermcdonald⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@HeatherMcDonaldOfficial Learn more about your ad choices. Visit podcastchoices.com/adchoices

I am the ring that no laurels adorn,A puckered little star at the edge of the form.No medals are pinned to my tireless skin,Yet I toil and labor each day, all from within. Through tempests of spice and fast food you regret,The burdens the rest of the body forgets.I clench through trials both noble and dire,An unsung sentinel forged in fire. But even the steadfast may weary and ache,May whisper, “Dear world, give me one gentle break”.A balm, a rest, a moment of grace,For I too am part of this curious place. Through trials and toil, both small and bold,One should never overlook, even the smallest of holes.I have found a truth both simple and fair:Even the lowliest ring merits tenderness and care. To see if you're eligible for the new GLP-1 pill on Ro, go to: https://Ro.co/BALD To get fifty percent off your first month of Green Chef, then twenty percent off for two months with free shipping, use code 50BALD at: https://Greenchef.com/50BALD Get organized, refreshed, and back on track this new year for WAY less with Wayfair! To shop all things home, head to: https://Wayfair.com Need a website or domain? Head to Squarespace.com for a free trial, and when you're ready to launch, save 10% off your first purchase of a website or domain at: ⁠⁠https://www.Squarespace.com/BALD⁠ Join Rakuten to start saving money today! Join for free by downloading the app or going to: https://Rakuten.com Follow Trixie: @TrixieMattel Follow Katya: @Katya_Zamo To watch the podcast on YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/TrixieKatyaYT⁠⁠⁠⁠⁠⁠⁠⁠ To check out our official YouTube Clips Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/TrixieAndKatyaClipYT⁠⁠⁠⁠⁠⁠⁠⁠ Don't forget to follow the podcast for free wherever you're listening or by using this link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/thebaldandthebeautifulpodcast⁠⁠⁠⁠⁠⁠⁠⁠ If you want to support the show, and get all the episodes ad-free go to: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thebaldandthebeautiful.supercast.com⁠⁠⁠⁠⁠⁠⁠⁠ To check out future Live Podcast Shows, go to: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://trixieandkatya.com/#tour⁠⁠⁠⁠⁠⁠⁠⁠ To check out the Trixie Motel in Palm Springs, CA: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.trixiemotel.com⁠⁠⁠⁠⁠⁠⁠⁠ Listen and Watch Anywhere! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/thebaldandthebeautifulpodcast⁠⁠⁠⁠⁠⁠⁠⁠ Follow Trixie: Official Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.trixiemattel.com⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@trixie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/trixiemattel⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/trixiemattel⁠⁠⁠⁠⁠⁠⁠⁠ Twitter (X): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/trixiemattel⁠⁠⁠⁠⁠⁠⁠⁠   Follow Katya: Official Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.welovekatya.com⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@katya_zamo⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/welovekatya⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/katya_zamo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Twitter (X): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/katya_zamo⁠⁠⁠⁠⁠⁠⁠⁠   #TrixieMattel #KatyaZamo #BaldBeautiful Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Pentagon says an attack on Iran may lead to significant risks for U.S. soldiers, allies and resources. The Wall Street Journal’s Alex Ward joins to discuss what one of the military’s top leaders is saying about the situation. Netflix’s bid to buy Warner Brothers just got a little more complicated. Deadline’s Dominic Patten explains why the DOJ is now involved. GLP-1 drugs such as Ozempic have exploded in popularity for their weight-loss effects. Dhruv Khullar of the New Yorker considers how they could be used to treat conditions like addiction. Plus, record snowfall hit parts of the northeast as a massive winter storm moved through, Mexico is experiencing more violence after the country’s top drug lord was killed, and President Trump prepares for his State of the Union address. Today’s episode was hosted by Yasmeen Khan.

Ozempic and other GLP-1 drugs have had a major impact in their short time on the market—currently, one in eight Americans say that they have been on GLP-1 drugs. As tens of millions of people take these medications, anecdotal evidence has emerged that they have a positive effect on alcohol abuse and drug addiction. Researchers are starting to run trials of the drugs for these purposes, and some speculate that GLP-1 drugs could even affect addiction behaviors such as gambling and online shopping. The physician and New Yorker medical correspondent Dhruv Khullar spoke with scientists and patients. “Over the course of my reporting,” he tells David Remnick, “I became more and more bullish on the idea that these are actually going to be really important molecules for the treatment of addiction.” Dhruv Khullar's “Can Ozempic Cure Addiction?” was published on February 9th. New episodes of The New Yorker Radio Hour drop every Tuesday and Friday. Join host David Remnick as he discusses the latest in politics, news, and current events in conversation with political leaders, newsmakers, innovators, New Yorker staff writers, authors, actors, and musicians.