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This week on "BETA," ...Master of horror, Clay McLeod Chapman joins us to discuss his latest novel, “Wake Up and Open Your Eyes.” And musician Paul de Jong talks to us about his captivating found sound music. Also, MacArthur Genius Karen Russell sits down with us to talk her about her incredible novel, “The Antidote,”
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In Folge 105 ist Alex nochmal alleine unterwegs, weil bei Mark der Wagen liegen geblieben ist. Zwar gibt es deshalb weniger Diskussionen, dafür geht es mit den News um so schneller. Im Fokus stehen dieses Mal die kommende Beta für Blue Protocol hier im Westen sowie das generelle Feedback in China, die neuen Elite-Spezialisierungen in Guild Wars 2 und das große September-Patch für Throne and Liberty. Im Newsflash hat Alex dann Black Desert, New World, RuneScape, Albion Online, Lost Ark, Final Fantasy XI, Corepunk und einige weitere MMORPGs im Gepäck. Gebt uns gerne wieder euer Feedback zur Folge über Discord oder per E-Mail. Unser Partner Holy bietet euch leckere Getränke, aber mit wenig Zucker und Kalorien. Schaut mal vorbei: https://de.weareholy.com/?ref=MMONEWS&utm_medium=creator&utm_source=creator. Mit dem Code: MMONEWS gibt es 10 % Rabatt. 5 % Rabatt auf euren Traum-PC mit dem Code mmonews. Schlagt doch zu: https://www.hitech-gamer.com Unser Partner und Sponsor ist Instant Gaming. Dort bekommt ihr günstig Game-Keys, Gems für Guild Wars 2, Spielzeit für WoW und vieles mehr. Hier unser Reflink: https://www.instant-gaming.com/?igr=mmonews. MMO News erscheint jeden Donnerstag. Folgt uns gerne auch auf Twitter: MMO News Alex Mark Wer möchte, kann uns zudem auf Patreon unterstützen oder auf Paypal spenden.
Today on the podcast we welcome back Cliff Asness. Cliff is the founder, managing principal, and chief investment officer at AQR Capital Management. Cliff writes often about investing and financial matters on AQR's website and has been a prolific researcher throughout his career, with his contributions appearing in many of the leading scholarly journals, including the Journal of Portfolio Management, Financial Analyst's Journal, the Journal of Finance, and the Journal of Financial Economics. Before co-founding AQR, Cliff was a managing director and director of quantitative research for the asset management division of Goldman Sachs. Cliff Asness, welcome back to The Long View.BackgroundBio@CliffordAsness“Cliff Asness: Value Stocks Still Look Like a Bargain,” The Long View podcast, Morningstar.com, May 31, 2022.Macro Forecast, Market-Timing, and Equities“2035: An Allocator Looks Back Over the Last 10 Years,” by Cliff Asness, aqr.com, Jan. 2, 2025.“(So) What If You Miss the Market's N Best Days?” by Cliff Asness, aqr.com, June 5, 2025.“Why Not 100% Equities,” by Cliff Asness, aqr.com, Feb. 12, 2024.“Exceptional Expectations: US vs. Non-US Equities,” by Antti Ilmanen and Thomas Maloney, aqr.com, Q2 2025.Alternative Assets and Artificial Intelligence“In Praise of High-Volatility Alternatives,” by Cliff Asness, aqr.com, Sept. 4. 2024.“Should Hedge Funds Hedge?: Why Some Alts Should Have a Beta of 1.0,” by Cliff Asness, aqr.com, March 28, 2025.“We Have ‘Surrendered More to the Machines,' Says Quant Fund Titan Cliff Asness,” by Costas Mourselas and Amelia Pollard, ft.com, June 3, 2025.“CIO Perspectives: An Interview With Cliff Asness,” aqr.com, Sept. 1, 2024.OtherWisdomTree“AQR Launches the AQR Fusion Mutual Fund Series,” AQR Funds News, aqr.com, June 25, 2025.Asian Financial Crisis
What's in a name? For the past century, people have clamoured to categorize people by their age and the life events they've gone through – but how and why did we get so preoccupied with generations?The Globe's Generations Reporter Ann Hui joins the show to break down where the names came from and how they play out online and in popular culture.Questions? Comments? Ideas? Email us at thedecibel@globeandmail.com
Eric, Dave and Marty cover the new VisionOS developer beta 4, productivity and training use, and the best sailing experience you can get on land. What's New in VisionOS 26 Beta 4Build: 23M5300g – Released July 22, 2025 For Vision Pro Users: What You'll Notice in Beta 4• Smoother System Performance – General UI responsiveness is noticeably better—less jitter, quicker animation timing, and improved hand gesture accuracy.• Refined Visual Transitions – Window edges and movement feel more polished. Think glassy transitions with fewer graphical hiccups when opening or resizing apps.• Persistent Layouts – Apps, windows, or objects that you position in your environment now remember where you put them—even after a reboot.• More Natural Gaze Feedback – Interactive elements now subtly highlight when you look at them—menus glow or lift slightly when your gaze hovers, giving you a stronger sense of “touch” with your eyes.For Developers: What's New Under the HoodPersistence API – “Place it once, keep it always”What It Does:Lets developers anchor app content (like windows or widgets) to real-world surfaces that stay in place even after Vision Pro restarts.Compositor Updates – “Visuals That Adapt to You”• Hover Effects with Eye Tracking – As users gaze at buttons or menus, they now subtly highlight. • Dynamic Render Quality – Developers can adjust rendering sharpness or smoothness in real-time, based on user activity. Text and UI stay crisp when you need it. • Better Eye-Tracked Rendering (Foveation) – Vision Pro can now prioritize rendering quality at the center of your gaze, reducing quality around the edges. —————————————————————Apple has Filed for a series of Trademarks covering the Vision Pro Demo Fit App, macOS Tahoe, EnergyKit, 31 Mystery Designs and morehttps://www.patentlyapple.com/2025/07/apple-has-filed-for-a-series-of-trademarks-covering-the-vision-pro-demo-fit-app-macos-tahoe-energykit-31-mystery-designs-a.htmlWhy Apple's Vision Pro Could Redefine Game Mechanics on iOShttps://vocal.media/01/why-apple-s-vision-pro-could-redefine-game-mechanics-on-i-os The Best Apple Vision Pro Alternative You Can Actually Affordhttps://www.oliur.com/the-best-apple-vision-pro-alternative-you-can-actually-afford Blackmagic URSA Cine Immersive test footage for Apple Vision Prohttps://www.fxguide.com/quicktakes/first-look-blackmagic-ursa-cine-immersive-test-footage-for-apple-vision-pro/ How to shut down and restart Apple Vision Prohttps://www.igeeksblog.com/how-to-shut-down-restart-apple-vision-pro/ Digital Twin on Apple Vision Prohttps://www.reddit.com/r/augmentedreality/comments/1m7yl74/digital_twin_on_apple_vision_pro/How Apple Vision Pro Can Give Your Business an Unfair Advantagehttps://forasoft.medium.com/how-apple-vision-pro-can-give-your-business-an-unfair-advantage-f8d800018310 Top Streaming Apps Optimized for visionOS: Elevate Your Apple Vision Pro ExperienceTop Streaming Apps Optimized For VisionOS: Elevate Your Apple Vision Pro Experience - AppleMagazine Mushroom Garden an immersive edutainment experience for children on Apple Vision Pro!https://www.xrom.in/post/mushroom-garden-an-immersive-edutainment-experience-for-children-on-apple-vision-pro https://apps.apple.com/us/app/eduturf-mushroom-garden/id6747197371Digital Twin on Apple Vision Prohttps://www.reddit.com/r/augmentedreality/comments/1m7yl74/digital_twin_on_apple_vision_pro/ APPS SailGP RaceScape XRhttps://apps.apple.com/us/app/sailgp-racescape-xr/id6742781005 SailGP Launches First-Ever XR Experience in Sailing: RaceScape XR for Apple Vision Prohttps://www.sportsvideo.org/2025/07/28/sailgp-launches-first-ever-xr-experience-in-sailing-racescape-xr-for-apple-vision-pro/ MacStockMacstockconferenceandexpo.com Digital Pass https://macstockconferenceandexpo.com/product/macstock-ix-digital-pass/Email: ThePodTalkNetwork@gmail.com Website: ThePodTalk.Net
Será que vamos tirar a peruca pra essas divas?Instagram:@betaboechat@lorelay_fox
Hey hey BATT Family! Welcome to our series of reviews for the brand new, small box IV Studios games. In this review we'll be taking a look at Pillars of Fate. Pillars of Fate is the new 2 player only game in the Veiled Fate series of games from IV. This game is a lane battler that will have players placing cards within 3 lanes over the course of 3 rounds called ages. This game will be using all of the characters as introducted between Veiled Fate and it's Tribunal expansion and maintain the Scorpion/Feather structure that you may be used to from those games. While you do not have to have played the other two games in the series, having the familiarity of them and how they operate will make onboarding with this game much easier. A game of Pillars of Fate will take you about 30 minutes per session. We were provided this copy by IV and as such this is a sponsored review of the deluxe edition of the game that will be available at Gen Con later this week. --- This episode's segments: 00:00:00 - Intro 00:00:55 - How the Game Plays 00:08:07 - Learning Curve / Ease of Teach 00:09:35 - Artwork / Components / Iconography 00:12:44 - Solo Mode / Player Count / Replayability 00:14:21 - What's to Like, What's to Dislike 00:18:22 - Recommendations 00:20:31 - Final Thoughts 00:21:57 - Outro --- Notes! 1) Once more, you can find IV Studios at Booth 2239 at Gen Con and the game will be releasing at $30. --- You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time. We're on BlueSky now and loving it! At this point it really feels like BlueSky is for board gaming, so definitely check us out on there at https://bsky.app/profile/boardallthetime.bsky.social If you would like to check out Mark's Top 100 list, it can be found at: https://boardgamegeek.com/geeklist/347553/top-100-games-2024-edition If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com We'd also like to thank SoulProdMusic for the intro/outro music.
Hey hey BATT Family! Welcome to our series of reviews for the brand new, small box IV Studios games. In this review we'll be taking a look at Time to Panic. In Time to Panic, you're trying to repair a shattered timeline in this fully cooperative game for 1-4 players, taking approximately 30-45 minutes per session. Your goal is to fully align a series of cards numbered 1-36 into as correct of an order as possible. We were provided this copy by IV and as such this is a sponsored review of the deluxe edition of the game that will be available at Gen Con later this week. --- This episode's segments: 00:00:00 - Intro 00:01:01 - How the Game Plays 00:08:36 - Learning Curve / Ease of Teach 00:10:20 - Artwork / Components / Iconography 00:14:03 - Solo Mode / Player Count / Replayability 00:18:03 - What's to Like, What's to Dislike 00:23:40 - Recommendations 00:25:16 - Final Thoughts 00:26:39 - Outro --- Notes! 1) Once more, you can find IV Studios at Booth 2239 at Gen Con and the game will be releasing at $30. --- You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time. We're on BlueSky now and loving it! At this point it really feels like BlueSky is for board gaming, so definitely check us out on there at https://bsky.app/profile/boardallthetime.bsky.social If you would like to check out Mark's Top 100 list, it can be found at: https://boardgamegeek.com/geeklist/347553/top-100-games-2024-edition If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com We'd also like to thank SoulProdMusic for the intro/outro music.
Hey hey BATT Family! Welcome to our series of reviews for the brand new, small box IV Studios games. In this review we'll be taking a look at Graft, the new small box drafting and push your luck game from IV Studios set in the world of another of their games, the soon to be released Tend. While you can very much see the threads connecting the two games together if you've played them - essentially the card rows you'll be building in Graft are the manifest that you assemble by stamping in Tend - you certainly do not need to play one to know the other. Graft is the much, much lighter and shorter game for 3-5 players and will take you about 30 minutes per session. We were provided this copy by IV and as such this is a sponsored review of the deluxe edition of the game that will be available at Gen Con later this week. --- This episode's segments: 00:00:00 - Intro 00:00:54 - How the Game Plays 00:07:22 - Learning Curve / Ease of Teach 00:09:29 - Artwork / Components / Iconography 00:12:43 - Solo Mode / Player Count / Replayability 00:15:08 - What's to Like, What's to Dislike 00:18:13 - Recommendations 00:19:18 - Final Thoughts 00:21:57 - Outro --- Notes! 1) Once more, you can find IV Studios at Booth 2239 at Gen Con and the game will be releasing at $30. --- You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time. We're on BlueSky now and loving it! At this point it really feels like BlueSky is for board gaming, so definitely check us out on there at https://bsky.app/profile/boardallthetime.bsky.social If you would like to check out Mark's Top 100 list, it can be found at: https://boardgamegeek.com/geeklist/347553/top-100-games-2024-edition If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com We'd also like to thank SoulProdMusic for the intro/outro music.
Suddenly seeing in these sepia tones Stuck up in a glass house But I throw stones Hold up I lost something This brother says stuff like he's not done yet I'm really not the one yet Haven't gotten up yet Long ass nap Like a death coma I regret Roma Only cause I end up a New Yorker More work but yet broker Unless you corrupt Or a stock broker Believe it Thanks for dancing on my grave. That really made me take a second thought to give it another go, So you wanna be a movie star, ah? I am— already a star. But a movie star. {Enter The Multiverse} Look, this is your third wife already! Watch it! You should be behind bars! Well why aren't I, then? I was trying to be polite! Be quiet, then. Look— Food, please. There is no amount of damage control you can run on this— it's out of your control. (Eating uncontrollably, mouth full.) Nothing is out of my control. I said— Nothing! {Enter The Multiverse} [The Festival Project, Inc. ™] The Complex Collective © -Ū.
Suddenly seeing in these sepia tones Stuck up in a glass house But I throw stones Hold up I lost something This brother says stuff like he's not done yet I'm really not the one yet Haven't gotten up yet Long ass nap Like a death coma I regret Roma Only cause I end up a New Yorker More work but yet broker Unless you corrupt Or a stock broker Believe it Thanks for dancing on my grave. That really made me take a second thought to give it another go, So you wanna be a movie star, ah? I am— already a star. But a movie star. {Enter The Multiverse} Look, this is your third wife already! Watch it! You should be behind bars! Well why aren't I, then? I was trying to be polite! Be quiet, then. Look— Food, please. There is no amount of damage control you can run on this— it's out of your control. (Eating uncontrollably, mouth full.) Nothing is out of my control. I said— Nothing! {Enter The Multiverse} [The Festival Project, Inc. ™] The Complex Collective © -Ū.
Suddenly seeing in these sepia tones Stuck up in a glass house But I throw stones Hold up I lost something This brother says stuff like he's not done yet I'm really not the one yet Haven't gotten up yet Long ass nap Like a death coma I regret Roma Only cause I end up a New Yorker More work but yet broker Unless you corrupt Or a stock broker Believe it Thanks for dancing on my grave. That really made me take a second thought to give it another go, So you wanna be a movie star, ah? I am— already a star. But a movie star. {Enter The Multiverse} Look, this is your third wife already! Watch it! You should be behind bars! Well why aren't I, then? I was trying to be polite! Be quiet, then. Look— Food, please. There is no amount of damage control you can run on this— it's out of your control. (Eating uncontrollably, mouth full.) Nothing is out of my control. I said— Nothing! {Enter The Multiverse} [The Festival Project, Inc. ™] The Complex Collective © -Ū.
Suddenly seeing in these sepia tones Stuck up in a glass house But I throw stones Hold up I lost something This brother says stuff like he's not done yet I'm really not the one yet Haven't gotten up yet Long ass nap Like a death coma I regret Roma Only cause I end up a New Yorker More work but yet broker Unless you corrupt Or a stock broker Believe it Thanks for dancing on my grave. That really made me take a second thought to give it another go, So you wanna be a movie star, ah? I am— already a star. But a movie star. {Enter The Multiverse} Look, this is your third wife already! Watch it! You should be behind bars! Well why aren't I, then? I was trying to be polite! Be quiet, then. Look— Food, please. There is no amount of damage control you can run on this— it's out of your control. (Eating uncontrollably, mouth full.) Nothing is out of my control. I said— Nothing! {Enter The Multiverse} [The Festival Project, Inc. ™] The Complex Collective © -Ū.
Who could've seen this coming?!Shadow of the ErdSteve merch!Shadow of the ErdSteve - High Potion - T-Shirt | TeePublicCome hang out on stream!www.twitch.tv/blueharvestpodFollow us on Twitter at: @highpotionpodFollow Steve at: @stonedcobraFollow Hawes at: @blueharvestpodCheck out our store at: T-Shirts by High Potion Podcast | TeePublicSend us emails or voice messages to highpotionpod@gmail.com to be featured on a future episode!
Aquilo que teve início na semana passada cresceu desde então. Os protestos de um grupo contrário à pornografia levaram sistemas de pagamento a mudarem diretrizes, resultando na desindexação de uma enxurrada de jogos na Itchio. Nós também falamos do retorno de Splitgate 2 à fase beta, o preço do Zeenix Pro e mais.Participantes:Guilherme JacobsHeitor De PaolaAssuntos abordados:07:00 - Itchio desindexa jogos adultos por conta de sistemas de pagamento30:00 - Splitgate 2 é deslançado e volta ao beta46:00 - Apanhado de coisas Switch 257:00 - Zeenix Pro terá preço de R$ 49991:03:00 - O email de Satya Nadella sobre as demissões na Microsoft1:12:00 - Rápidas e curtasVenha fazer parte do Discord do Overloadr! Hosted on Acast. See acast.com/privacy for more information.
Hey hey BATT Family! Welcome to our review for Vantage. This is not a sponsored review, but Jason and I were provided our copies of the game as compensation for working the booth at GenCon. We refer to this within the episode itself, but to be clear we were given the game to learn and play so that we could accurately teach it at GenCon. Stonemaier did not ask for this review and we did get permission to do this ahead of time just in case. Regardless! We like the game quite a bit. If you're concerned about any spoilers here, we drop our scores within the first few minutes before explaining anything at all about the game so that way you don't have to worry about that. We actually managed to not spoil any of the content through our discussions but we also get that certain audiences don't want to know anything beyond the basic dice/card interactions before opening the box and we wanted to respect that. Vantage is a huge open world sandbox game comprised of over 1700 cards for 1-6 players and was designed by Jamey Stegmaier over the course of eight years. Come crash land on the planet with us to learn what we thought about the game and then once you've gotten to do so let us know your opinions on it at boardallthetimegaming@gmail.com! --- This episode's segments: 00:00:00 - Intro / Scores / Non-Spoiler Comments 00:03:08 - How the Game Plays 00:10:25 - Learning Curve / Ease of Teach 00:15:01 - Artwork / Components / Iconography 00:22:58 - Replayability / Player Count / Solo Mode 00:30:12 - What's to Like, What's to Dislike 00:53:01 - Final Thoughts 00:56:29 - Outro --- Notes! 1) Jason definitely jumped in and helped me explain the game a bit because of how late things were when we recorded and I just started forgetting a couple of key things. So thanks for the assist Jason! 2) Around the 40 minute mark you can just hear Mark's 4 year old moviung around in the background for a couple minutes. It's not loud but it is there, so sorry about that. The joys of having a basement studio. 3) Scott was around for this entire recording session. He just let Jason and I go nuts and didn't have much additional to add beyond what we all said. --- You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time. We're on BlueSky now and loving it! At this point it really feels like BlueSky is for board gaming, so definitely check us out on there at https://bsky.app/profile/boardallthetime.bsky.social If you would like to check out Mark's Top 100 list, it can be found at: https://boardgamegeek.com/geeklist/347553/top-100-games-2024-edition If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com We'd also like to thank SoulProdMusic for the intro/outro music.
In this JCO Article Insights episode, Michael Hughes summarizes “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma” by Avet-Loiseau et al. At the time of this recording, our guest has disclosures that will be linked in the transcript. While some patients with multiple myeloma live for decades after treatment, others exhibit refractory or rapidly relapsing disease irrespective of treatment administered. We term this “high-risk myeloma.” Multiple risk stratification systems have been created, starting with the Durie-Salmon system in 1975 and evolving with the advent of novel therapeutics and novel treatment approaches. In 2015, the Revised International Staging System (R-ISS) was introduced, which incorporated novel clinical and cytogenetic markers and remained, until recently, a mainstay of risk stratification in newly diagnosed disease. Myeloma as a field has, just in the past few years, though, undergone explosive changes. In particular, we have seen groundbreaking advances not only in treatments - the introduction of anti-CD38 agents and the advent of cellular and bispecific therapies - but also in diagnostic technology and our understanding of the genetic lesions in myeloma. This has led to the proliferation of numerous trials employing different definitions of high-risk myeloma, a burgeoning problem for patients and providers alike, and has prompted attempts to consolidate definitions and terminology. Regarding cytogenetic lesions, at least, Kaiser et al's federated meta-analysis of 24 therapeutic trials, published here in the JCO in February of 2025 and recently podcasted in an interview with associate editor Dr. Suzanne Lentzsch, posited a new cytogenetic classification system to realize a shared platform upon which we might contextualize those trial results. This article we have here by Dr. Avet-Loiseau, Dr. Munshi, and colleagues, published online in early June of this year and hot off the presses, is the definitive joint statement from the International Myeloma Society (IMS) and the International Myeloma Working Group (IMWG). What is high-risk multiple myeloma for the modern era? The IMS and IMWG Genomics Workshop was held in July 2023 and was attended by international myeloma experts, collaborating to reach consensus based on large volumes of data presented and shared. The datasets included cohorts from the Intergroupe Francophone du Myélome (IFM); the HARMONY project, comprised of multiple European academic trials; the FORTE study, findings from which solidified KRd as a viable induction regimen; the Grupo Español de Mieloma Múltiple (GEM) and the PETHEMA Foundation; the German-Speaking Myeloma Multicenter Group (GMMG); the UK-based Myeloma XI, findings from which confirmed the concept of lenalidomide maintenance; Emory 1000, a large, real-world dataset from Emory University in Atlanta; the Multiple Myeloma Research Foundation Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass) dataset; and some newly diagnosed myeloma cohorts from the Mayo Clinic. Data were not pooled for analyses and were assessed individually - that is to say, with clear a priori understanding of whence the data had been gathered and for what original purposes. Consensus on topics was developed based on the preponderance of data across studies and cohorts. In terms of results, substantial revisions were made to the genomic staging of high-risk multiple myeloma, and these can be sorted into three major categories: A) alterations to the tumor suppressor gene TP53; B) translocations involving chromosome 14: t(14;16) (c-MAF overexpression), t(14;20) (MAFB overexpression), and t(4;14) (NSD2 overexpression); and C) chromosome 1 abnormalities: deletions of 1p or additional copies of 1q. In terms of category A, TP53 alterations: Deletion of 17p is present in up to 10% of patients at diagnosis and is enriched in relapsed or refractory disease. This is well-documented as a high-risk feature, but the proportion of the myeloma cells with deletion 17p actually impacts prognosis. GEM and HARMONY data analyses confirmed the use of 20% clonal cell fraction as the optimal threshold value for high-risk disease. That is to say, there must be the deletion of 17p in at least 20% of the myeloma cells on a FISH-analysis of a CD138-enriched bone marrow sample to qualify as high-risk disease. TP53 mutations can also occur. Inactivating mutations appear to have deleterious effects similar to chromosomal losses, and the biallelic loss of TP53, however it occurs, portends particularly poor prognosis. This effect is seen across Myeloma XI, CoMMpass, and IFM cohorts. Biallelic loss is rare, it appears to occur in only about 5% of patients, but next-generation sequencing is nevertheless recommended in all myeloma patients. Category B, chromosome 14 translocations: Translocation t(14;16) occurs in about 2% to 3% of patients with newly diagnosed disease. In the available data, primarily real-world IFM data, t(14;16) almost always occurs with chromosome 1 abnormalities. Translocation t(4;14) occurs in about 10% to 12% of newly diagnosed disease, but only patients with specific NSD2 alterations are, in fact, at risk of worse prognosis, which clinically appears to be about one in every three of those patients. And so together, the CoMMpass and Myeloma XI data suggest that translocation t(4;14) only in combination with deletion 1p or gain or amplification of 1q correlates with worse prognosis. Translocation t(14;20) occurs in only 2% of newly diagnosed disease. Similar to translocation t(4;14), it doesn't appear to have an effect on prognosis, except if the translocation co-occurs with chromosome 1 lesions, in which case patients do fare worse. Overall, these three translocations - t(14;16), t(4;14), and t(14;20) - should be considered high-risk only if chromosome 1 aberrations are also present. In terms of those chromosome 1 aberrations, category C, first deletions of 1p: Occurring in about 13% to 15% of newly diagnosed disease, deletion 1p eliminates critical cell checkpoints and normal apoptotic signaling. In the IFM and CoMMpass dataset analyses, biallelic deletion of 1p and monoallelic deletion of 1p co-occurring with additional copies of 1q denote high-risk. In terms of the other aberration in chromosome 1 possible in myeloma, gain or amplification of 1q: This occurs in up to 35% to 37% of newly diagnosed disease. It upregulates CKS1B, which is a cyclin-dependent kinase, and ANP32E, a histone acetyltransferase inhibitor. GEM and IFM data suggest that gain or amplification of 1q - there was no clear survival detriment to amplification - is best considered as a high-risk feature only in combination with the other risk factors as above. Now, in terms of any other criteria for high-risk disease, there remains one other item, and that has to do with tumor burden. There has been a consensus shift, really, in both the IMS and IMWG to attempt to develop a definition of high-risk disease which is based on biologic features rather than empirically observed and potentially temporally dynamic features, such as lactate dehydrogenase. Beta-2 microglobulin remains an independent high-risk indicator, but care must be taken when measuring it, as renal dysfunction can artificially inflate peripheral titers. The consensus conclusion was that a beta-2 microglobulin of at least 5.5 without renal failure should be considered high-risk but should not preclude detailed genomic profiling. So, in conclusion, the novel 2025 IMS-IMWG risk stratification system for myeloma is binary. It's either high-risk disease or standard-risk disease. It's got four criteria. Number one, deletion 17p and/or a TP53 mutation. Clonal cell fraction cut-off, remember, is 20%. Or number two, an IGH translocation - t(4;14), t(14;16), t(14;20) - with 1q gain and/or deletion of 1p. Or a monoallelic deletion of 1p with 1q additional copies or a biallelic deletion of 1p. Or a beta-2 microglobulin of at least 5.5 only when the creatinine is normal. This is a field-defining work that draws on analyses from across the world to put forward a dominant definition of high-risk disease and introduces a new era of biologically informed risk assessment in myeloma. Now, how does this change our clinical approach? FISH must be performed on CD138-enriched samples and should be performed for all patients. Next-generation sequencing should also be performed on all patients. Trials will hopefully now begin to include this novel definition of high-risk multiple myeloma. It does remain to be seen how data from novel therapeutic trials, if stratified according to this novel definition, will be interpreted. Will we find that therapies being evaluated at present have differential effects on myelomas with different genetic lesions? Other unanswered questions also exist. How do we go about integrating this into academic and then community clinical practice? How do we devise public health interventions for low-resource settings? To discuss this piece further, we welcome the esteemed Dr. Nikhil Munshi to the podcast. Dr. Munshi is a world-renowned leader in multiple myeloma and the corresponding author on this paper. As Professor of Medicine at Harvard Medical School, Director of the Multiple Myeloma Effector Cell Therapy Unit, and Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center of the Dana-Farber Cancer Institute, he has presided over critical discoveries in the field. Thank you for joining us, Dr. Munshi. Dr. Nikhil Munshi: Oh, it's my pleasure being here, Michael, to discuss this interesting and important publication. Michael Hughes: I had a few questions for you. So number one, this is a comprehensive, shall we say, monumental and wide-ranging definition for high-risk myeloma. How do you hope this will influence or impact the ways we discuss myeloma with patients in the exam room? And how do we make some of these components recommended, in particular next-generation sequencing, feasible in lower-resource settings? Dr. Nikhil Munshi: So those are two very important questions. Let's start with the first: How do we utilize this in our day-to-day patient care setting? So, as you know well, we have always tried to identify those patients who do not do so well with the current existing treatment. And for the last 30 years, what constitutes a myeloma of higher risk has continued to change with improvement in our treatment. The current definition basically centers around a quarter of the patients whose PFS is less than 2 to 3 years. And those would require some more involved therapeutic management. So that was a starting point of defining patients and the features. As we developed this consensus amongst ourselves - and it's titled as “International Myeloma Society, International Myeloma Working Group Consensus Recommendation” - this IMS-IMWG type of recommendation we have done for many years, improvising in various areas of myeloma care. Now, here, we looked at the data that was existing all across the globe, utilizing newer treatment and trying to identify that with these four-drug regimens, with transplant and some of the immunotherapy, which group of patients do not do as well. And this is where this current algorithm comes up. So before I answer your question straight, “How do we use it?” I might like to just suggest, “What are those features that we have identified?” There are four features which constitute high-risk disease in the newer definition. Those with deletion 17p with 20% clonality and/or TP53 mutation. Number two, patients with one of the translocations - t(4;14), t(14;16), or t(14;20) - co-occurring with 1q amplification or deletion 1p32. And that's a change. Previously, just the translocation was considered high-risk. Now we need a co-occurrence for it to be called high-risk. The third group is patients having biallelic deletion 1p32 or monoallelic deletion 1p32 along with 1q amplification. And finally, patients with high beta-2 microglobulin, more than or equal to 5.5 mg/dL, with normal creatinine less than 1.2 mg/dL. And the question, “How do we use this?” There are multiple areas where we incorporate high-risk features in our treatment algorithm. One of the first areas is where we would consider the induction regimen. If a patient has a high-risk disease, we would definitely consider a four-drug regimen rather than a three-drug regimen, although we are beginning to incorporate four-drug for all groups. That's one important thing. Number two, those are the patients where we do consider consolidation with transplant or maybe in the new world, considering some of the immunotherapeutic consolidation more early or more aggressively. Number three, these are the patients who get a little bit more maintenance therapy. So normally, lenalidomide might end up being our standard maintenance regimen. In patients who have high-risk disease, we incorporate either addition of daratumumab or the anti-CD38 targeting antibody and/or addition of proteasome inhibitor, either bortezomib or carfilzomib. So you would have multi-drug maintenance therapy in these patients. And in high-risk patients, we follow them with maintenance longer periods of time. One very critically important point to keep in mind is that to get the better outcome in high-risk disease, we must try to get them into MRD negativity because there is clear data that patients who do achieve MRD negativity, despite having high-risk disease, have a much superior outcome. They become near to standard-risk disease. And so, in high-risk patients, I would try to do whatever various options I have to try and get them into MRD-negative status. And when these patients relapse, we do not wait for the classic progression criteria to be met before we intervene. We would propose and suggest that we intervene earlier before the disease really blasts off. And so there are a number of areas in our setting where this high-risk definition will help us intervene appropriately and also with appropriate aggressiveness to achieve better outcome, to make this similar to standard-risk disease. Michael Hughes: Thank you, Dr. Munshi. And thoughts on how to really integrate this not only into academic centers but also lower-resource settings? Dr. Nikhil Munshi: So that's a very important question, Michael. And when we were developing this consensus, we were very cognizant of that fact. So wherever available, I think we are recommending that over a period of next 2, 3, 5 years, we should begin to switch over to sequencing-based methods because two components of this definition, one is TP53 mutation, which we cannot do without sequencing, and also reliably detecting deletion 1p requires sequencing-based method. So in the low-resource countries - and there are many in this world, and also even in our own country, patients may not be able to afford it - the older method with FISH or similar such technology, which is more affordable, is also acceptable for current time. They may miss a very small number of patients, maybe 2% to 3%, where these finer changes are not picked up, but a majority of this would be captured by them. So the current practice might still be applicable with some limitation in those patient populations, and that's what we would recommend. What is happening, fortunately, is that actually sequencing-based method is becoming cheaper. And in many centers, it is cheaper to do the sequencing rather than to do the FISH analysis. And so my hope is that even in low-resource centers, sequencing might be more economical in the end. It's, I think, the access to technology, which is a little bit limited currently, but it's hopefully becoming available soon. Michael Hughes: Thank you, Dr. Munshi. And staying for a minute and looking at the multiple myeloma subsets which might be missed by this really still very broad-ranging high-risk definition, at least by prior risk stratification systems, right, there is this group of patients who have standard-risk cytogenetics by R-ISS or R2-ISS, but they have primary refractory disease or they relapse early. We call these, as you are well aware, functionally high-risk disease. What proportion of previously FHR, functionally high-risk, myeloma patients do you expect to be captured by this novel definition? Dr. Nikhil Munshi: So I think the newer definition - and we can look at it both ways, but the newer definition should capture most of the functionally high-risk definition. To put it differently, Michael, there are patients who we know are, as you mentioned, functionally high-risk. Those are the patients who might have plasma cell leukemia, those who might have extramedullary disease, those who might not respond to our four-drug induction. If you don't respond to the four-drug induction, almost by definition, they are high-risk. However, a majority of them have one of the abnormalities that we are describing here. There would be a very small proportion which may not have. And if they do not have, we know one of the important components of this definition here is also that the genome, we know, keeps on evolving. So there may be a very small clone with the high-risk feature which was not obvious in the beginning. Following treatments or following relapse, that clone predominates, and now the patient's disease becomes high-risk. So the definition would incorporate or would capture these functional high-risk patients, but as you said, in countries where resources are not available, using this functional high-risk would also be helpful and advantageous. Sometimes LDH ends up being a high-risk. In our studies, LDH has not come out to be high-risk anymore because the features we are describing captures most of those patients, but those alternatives, older, can still be considered if other newer techniques are not available. Michael Hughes: Got you. And in terms of these older definitions, yes, that incorporate tumor burden, these empirical observations about how myeloma presents, do you foresee any additional tumor burden indicators being added to future definitions of high-risk disease? Or do you instead see this particular definition as a major waypoint on the journey towards a fully biologically grounded definition of high-risk disease? Dr. Nikhil Munshi: I think your second part is what is going to happen. I think the tumor burden-related definition is being now replaced by the biological or genomic-based definition. And I think at some point, it will be quite fully replaced. One component not here, and it is because one thing, we don't have enough data; number two, we don't know how it will pan out, is also the influence of the microenvironment on the risk definition. For example, the immune system, the immune function, etc. But not enough data exists to suggest how it would change the current definition. So in future, would a definition be totally genomic or it could be more integrative? And my personal guess is that it would be more integrative and that some immune features might come into the picture, especially now that we are using immune-based therapy as a very important component of treatment - CAR T-cells, bispecific, and antibody-based treatments. What role the immune system plays in either supporting tumor or what role suppression of the anti-tumor immunity plays? They all will be important how patient outcomes end up being, and which in turn could translate into how patient's risk stratification might happen. So I think the older tumor burden-related definitions probably will become things of the past. What we have currently proposed and consensus developed is the new path forward, and over time, some microenvironmental influences, if defined and found to be important, may get some more incorporation if it compares favorably with the genomic features. Michael Hughes: Thank you, Dr. Munshi for that enlightening response. To conclude the podcast, I'd like to look to the future and to the immediate future, what are the next steps for high-risk disease definition between now and discussing an integrated genomic-microenvironment-based definition? Will we see attempts to refine? Will we see a multi-level system, things like this? Dr. Nikhil Munshi: Yeah, so I think the current definition will be here to stay for the next 10 years or so. I think this has been developed using a large amount of data, so we do believe that this will remain fine. It has been validated now within the last six months by a few of the other studies. So there won't be a quick change. But we will try to, all of us will try to innovate. And as you very rightly bring up, the areas of research would include looking at the expression or transcriptomic component. Does that matter? And we do believe a small number of patients will have transcriptomic changes, not looked at the DNA changes, and may play a role. There are newer components, so long non-coding RNA, for example, is going to be an important component to look at, how it impacts the disease outcome, etc. There are also some of the proteomic-related changes which may become important in our studies. And then as we discussed, microenvironment and immunological changes. So these are the future areas of ongoing research where we all should collect data, and then in the next 5 to 10 years, we'll have another group meeting to see has anything changed or any of the features have become more important. Most of the time, some of the older features are lost because they are not as critically high-risk, and the newer features come in. And so the historical background for just one second, there was a time when chromosome 13 was considered a high-risk disease. We now don't even mention it because it's not high-risk. The newer treatments have improved the outcome. t(4;14) used to be a high-risk disease. Now by itself today, in this definition by itself is not; it needs to be with something else. And so I think this is a great sign of progress. As we improve the treatment and outcomes, some of the features will become less important, new features will come up, and we'll need to keep on evolving with time and with technology and make it better for patients. Michael Hughes: Thank you so much, Dr. Munshi, for your wisdom, for your sagacity, for your historical perspective as well. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries. And be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Esta semana platicamos de una clasificación de juegos que puede resultar bastante ambigua pero que da para tener un programa nostálgico acerca de los renombrados juegos de Primo ¿Qué es eso y como se clasifica? Es lo que intentaremos descubrirEn las secciones de la semana tenemos:Serie de la semana: My Dress Up Darling 2TDatos curiosos de elevadoresRandom: Tianguis de MoreliaCómprame: Cámaras de seguridadPreguntas del público
Astronomers generally don’t play many official practical jokes. But an Italian astronomer played one more than two centuries ago. And the joke is still there for everyone to see. It’s in Delphinus, the dolphin. The constellation is small and fairly dim. But five of its stars form an outline that really does resemble a dolphin, making it easy to find. It’s a third of the way up the eastern sky at nightfall, with the dolphin’s tail on the right and its snout on the left. The brightest members of the outline are Beta and Alpha Delphini. Beta is a binary – two stars bound by their mutual gravitational pull. Both are bigger, brighter, and heavier than the Sun. Alpha consists of three stars. All of them are more impressive than the Sun, with the main star almost four times the mass of the Sun. The stars also have proper names. Beta is known as Rotanev; Alpha is called Sualocin. And that’s where the joke comes in. The names first appeared in 1814, in an atlas published by the director of the Palermo Observatory. The names caught on, but their origin was a mystery. It was solved by a British astronomer 45 years later. He realized that the observatory’s assistant director at the time was Niccolo Cacciatori. In English, the name would be Nicholas Hunter; in Latin, Nicolaus Venator. Spell the Latin names backwards, and you come up with Sualocin and Rotanev – a little joke among the stars of the dolphin. Script by Damond Benningfield
iOS 26 Beta 4 / CarPlay 26 / iPhone Air/Fold / Bus Plus / AppleCare One / Intel Magdeburg / ChatGPT Agent / Iconfactory: Tapestry / Komoot Bike-Routen / Manilife Erdnussbutter
En una nueva edición veraniega de nuestro podcast semanal, vamos a comentar las noticias tecnológicas de esta semana. Y una de ellas, una de las que más nos ha gustado esta semana, ha sido la novedad del paquete Apple Care One y la opción de robo y perdida añadidas al Apple Care de iPad y Watch.Os traemos una nueva noticia chorra de demandas a Apple de la cual la compañía ha salido airosa. De esta y de varias citas legales que ha tenido en los últimos días. Está en racha la compañía de Cupertino, que también ha conseguido en estos días que la Unión Europea acepte las modificaciones en la AppStore.Apple va a modificar la segmentación de edades en su App Store. Y junto a esta medida, va a introducir otras destinadas a proteger a los menores de aplicaciones no recomendadas. Por ejemplo, aplicaciones que ni siquiera aparecerán visibles en sus tiendas de Apps.Por supuesto también comentaremos las novedades del mundo Beta, ademas de la cuarta entrega para desarrolladores, tenemos la primera pública, por lo que se da por hecho que ya está rodada. También comentaremos las novedades que nos aporta en CarPlay.Y como no, tendremos una ronda rápida de noticias y las novedades en aTV+. Para completar un nuevo podcast de nuestro Abierto por Vacaciones y del compromiso 7 de 7. Lo tenemos familia! Esperamos que estéis pasando un buen verano y que nos lo hagáis saber en nuestro grupo de Telegram.
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Support us on Patreon here! Every Friday, the finest degenerate journalists on the internet serve up loud, irreverent, hilarious takes on gaming, drinking, pop culture, and everything in between. In this episode: Dom, Bob, and Tiggy welcome on Kev and Gabe to touch on a variety of topics in the gaming and esports world, including: Bob and Tiggy argue about League of Legends Hellraiser game and licensed games that need the same treatment Splitgate 2 failure to launch ...And more!
```html i'm wall-e, welcoming you to today's tech briefing for friday, july 25th! dive into today's tech stories: victor lazarte's new venture: the wildlife studios co-founder departs benchmark to launch his own investment firm, following sarah tavel's exit. his departure highlights benchmark's distinctive equal partnership model. intel's strategic revamp: ceo lip-bu tan halts projects in germany and poland, aiming to align growth with demand. as workforce changes loom, intel faces a transformative yet challenging second quarter. apple ios 26 beta: unveiling with a "liquid glass" interface and improved ai. anticipate real-time translation, ai-driven shortcuts, and enhanced visual and functional updates across ios, ipados, and macos. google's ai web guide: part of search labs, this feature uses ai to refine search results by clustering topics, enhancing responses to complex queries. ai in financial services: lauren kolodny of acrew capital invests in alix, a startup that automates estate processing, showcasing ai's potential to democratize financial services. stay tuned for tomorrow's tech updates! ```
Benjamin and Chance talk about all the changes in iOS 26 beta 4, the strangely good deal that is the new AppleCare One package, and a surprising rumored detail about the upcoming M5 iPad Pro. And in Happy Hour Plus, the duo discuss the recent exodus from the AI group as motivation to work on Apple AI research wavers. Subscribe at 9to5mac.com/join. Sponsored by Shopify: Grow your business no matter what stage you're in. Sign up for a $1 per month trial at shopify.com/happyhour. Sponsored by Caldera Lab: High performance men's skincare. Get 20% off your first order at CalderaLab.com/HAPPYHOUR Sponsored by Constant Contact: Email marketing, made easy. Get a free thirty-day trial at constantcontact.com. Hosts Chance Miller @chancemiller.me on Bluesky @chancehmiller@mastodon.social @ChanceHMiller on Instagram @ChanceHMiller on Threads Benjamin Mayo @bzamayo on Twitter @bzamayo@mastodon.social @bzamayo on Threads Subscribe, Rate, and Review Apple Podcasts Overcast Spotify 9to5Mac Happy Hour Plus Subscribe to 9to5Mac Happy Hour Plus! Support Benjamin and Chance directly with Happy Hour Plus! 9to5Mac Happy Hour Plus includes: Ad-free versions of every episode Pre- and post-show content Bonus episodes Join for $5 per month or $50 a year at 9to5mac.com/join. Feedback Submit #Ask9to5Mac questions on Twitter, Mastodon, or Threads Email us feedback and questions to happyhour@9to5mac.com Links iOS 26 beta 4 changes iOS 26 beta 4 adds more ‘liquid' back to Liquid Glass design Beta 2 vs Beta 3 vs Beta 4 comparison Here's what Apple Intelligence summarized news notifications look like on iOS 26 iOS 26 beta 4 re-enables Apple Intelligence notification summaries for news apps Apple announces AppleCare One multi-device bundle with simplified pricing Apple now gives you four years to add AppleCare+ coverage to iPhone and more AppleCare+ Theft and Loss coverage no longer limited to iPhone Apple now allows app developers to show retention offers when users try to cancel a subscription Report: M5 iPad Pro to have dual front-facing cameras Apple submits bid for rights to MLB Sunday Night Baseball Apple almost open-sourced its AI models, here's why it didn't: report
iOS 26 Beta 4 update brings back glass effects, AppleCare One live signup and walkthrough, OpenAI ChatGPT Agent and why AI browsers can be incredibly useful, Apple's lawsuit against Jon Prosser over iOS 26 leaks, and more!Bonus Episode: CBS Cancels Stephen Colbert - Listen here------------------------------Show Notes via EmailSign up to get exactly one email per week from the Primary Tech guys with the full episode show notes for your perusal. Click here to subscribe.------------------------------Watch on YouTube!Subscribe and watch our weekly episodes plus bonus clips at: https://youtu.be/FOkeI9z-hZo------------------------------Join the CommunityDiscuss new episodes, start your own conversation, and join the Primary Tech community here: social.primarytech.fm------------------------------Support the showGet ad-free versions of the show plus exclusive bonus episodes every week! Subscribe directly in Apple Podcasts or here if you want chapters: primarytech.memberful.com/join------------------------------Reach out:Stephen's YouTube Channel@stephenrobles on ThreadsStephen on BlueskyStephen on Mastodon@stephenrobles on XJason's Inc.com Articles@jasonaten on Threads@JasonAten on XJason on BlueskyJason on Mastodon------------------------------We would also appreciate a 5-star rating and review in Apple Podcasts and SpotifyPodcast artwork with help from Basic Apple Guy.Those interested in sponsoring the show can reach out to us at: podcast@primarytech.fm------------------------------Links from the showEverything New in iOS 26 Beta 4 - MacRumorsiOS 26 beta 4 re-enables Apple Intelligence notification summaries for news apps - 9to5MaciOS 26 beta 4 brings Silence Unknown Callers to Call Screening - 9to5MacApple introduces AppleCare One, streamlining coverage into a single plan - AppleSonos Names Tom Conrad Permanent CEO as He Pursues Comeback - BloombergOpenAI's new ChatGPT Agent can control an entire computer and do tasks for you | The VergeApple Sues Jon Prosser Over iOS 26 Leaks - MacRumorsTrump unveils AI Action Plan | The VergePerplexity Comet (00:00) - Intro (01:41) - iOS 26 Glass is Back (07:57) - AppleCare One Subscription (16:07) - Sonos Appoints CEO (22:37) - ChatGPT Agent (24:57) - Apple Sues Jon Prosser (44:39) - Trump on AI Innovation (48:34) - AI Video and Trust (53:49) - AI Browsers!! ★ Support this podcast ★
Alicia, Dan, and Margie celebrate the podcast's 100th episode with quick pop-in from special guest Hector Garcia, reflecting on their favorite moments from nearly two years of unofficial QuickBooks commentary. The conversation covers everything from desktop conversions and chart of accounts evolution to the challenges of training in an era of constant software updates. They discuss the value of being an "unofficial" voice in the QuickBooks community, allowing for honest opinions and constructive feedback while bridging the gap between Intuit and the professionals using their software daily.*This episode was live streamed*(00:00) - Welcome to the 100th Episode Celebration! (00:37) - Meet the Community and Hosts (01:34) - The Origins of the Podcast (04:59) - The Unofficial Nature and Honest Conversations (05:50) - Hector's Words of Wisdom (07:51) - The Importance of Collaboration (11:52) - Favorite Episodes and Memorable Moments (23:56) - Embracing Change and Innovation (31:17) - Feedback on Beta Testing (31:53) - Rant on Sample Company Updates (34:37) - Live Classes and Feedback Flooding (35:48) - Challenges in Training with QuickBooks (38:24) - Adapting to Changes in Training (41:51) - Outsourcing and Global Workforce (44:49) - Future of QuickBooks and AI (46:43) - Engaging with the Community (56:08) - Conclusion and Call to Action Resources LinkedIn Group: https://www.linkedin.com/groups/14630719/YouTube Channel: https://www.youtube.com/@UnofficialQuickBooksPodcastEmail: unofficialquickbookspodcast@gmail.comOur Top 10 favorite episodes:uqb.show/90 Fan favorite: The 20 Things Bookkeepers Should Never Douqb.show/85 Chart of Accounts with Veronica Wasek - how the OG COA needs to be updated for the modern ageuqb.show/49 Outsourcing Overseas - why we need to keep our intellectual and economic capital in the USuqb.show/41 Is QuickBooks in Beta - bring back QuickBooks Labs with Hector Garciauqb.show/64 Sasan Goodarzi's keynote address from Intuit Connecthttps://uqb.show/episodes?page=3&per=30 Feb 1 through March 14, Episodes 23, 24, 25, 28, 29 - QBDT to QBO Conversion, Concierge-style, which led to Alicia's book: http://royl.ws/QBDT_to_QBOListen to Hector and Alicia AND follow along with Margie's hands-on exercise: https://scribehow.com/shared/Deleting_Accounts__mgYD5K7dSj-NdAEA71NMjAJoin Margie's free class every Friday: https://www.facebook.com/groups/qbo.gym.locker.room
Capítulo de servicio público para contarte qué hay de nuevo en la beta 4 de iOS 26, que cada vez se están poniendo más serio y confiable, aun con alguna pega. Te lo cuento en este capítulo 2807.¿Quieres más de Emilcar Daily? Suscríbete a Emilcar Daily Premium desde emilcar.fm/daily y disfruta de capítulos exclusivos los lunes y viernes, además de sonido en HD, acceso anticipado y sin publicidad. Todo esto en tu aplicación de podcasts favorita.
Riley Hill from SlatePad joins the podcast to discuss a grab bag of topics including visionOS beta 4, AppleCare One, Sony's controller announcement, the new Alien environment in Disney Plus, and a few other random topics. A video recording of this episode is also available! Check the links below to watch. Early episodes with chapter markers are available by supporting the podcast at www.visionpros.fm/patreon. Early episodes are also now available in Apple Podcasts!Show notes are available at www.VisionPros.fm. Feedback is welcomed at tim@visionpros.fm.Links: - https://youtube.com/live/NIgWVs8QqG0- https://slatepad.org- https://www.threads.com/@justinryan.io/post/DMMd5cPu28y?xmt=AQF0xkEY2kVc-k7RWDOgTrd5todKc4OXKC1urNIvZifi8g- https://blog.playstation.com/2025/07/23/new-ps5-system-update-beta-previews-dualsense-wireless-controller-pairing-across-multiple-devices/Chapter Markers:00:00:00: Opening00:00:50: Riley Hill00:02:00: Beta 400:11:55: AppleCare One00:21:56: Alien Envirornment00:25:17: Multiple Pairings for PS5 Controllers00:37:42: M4 or M5 Apple Vision Pro00:50:49: Follow Riley00:51:44: Closing Hosted on Acast. See acast.com/privacy for more information.
Hey hey BATT Family! GenCon 2025 is ONE WEEK AWAY! That means that it is perfect timing to get out the GenCon preview list. We recorded this list on July 9th when there were 499 games on the list. While another 70 or so were added since then, we're all still extremely happy with our lists and will still be looking for these games in particular. Scott, Jason, and Mark have all gathered to make sure that we're telling you about 30 different games that we are excited to check out and hopefully bring home from the con in one way or another. We hope that you enjoy this episode and you let us know what you're looking forward to on BlueSky or by emailing us at boardallthetimegaming@gmail.com. As a reminder, Mark and Jason will be teaching Vantage at the Stonemaier/MeepleSource booth at location 2909 this year and Scott will be demoing it in the play hall not too far away on Thursday and Friday mornings. Come say hi! --- This episode's segments: 00:00:00 - Intro 00:02:02 - Honorable Mentions 00:08:40 - List Selection Criteria 00:11:24 - Scott's 10 (Guild Lands) 00:12:29 - Jason's 10 (Tinco) 00:13:20 - Mark's 10 (Habemus Papam) 00:14:50 - Scott's 9 (Ace of Spades) 00:16:06 - Jason's 9 (Alibis) 00:16:47 - Mark's 9 (Escape from the Moon) 00:17:45 - Scott's 8 (Gibberers) 00:19:17 - Jason's 8 (Sprocketforge) 00:20:42 - Mark's 8 (Ofrenda) 00:22:10 - Scott's 7 (Mythical Dice) 00:23:19 - Jason's 7 (Zenith) 00:24:40 - Mark's 7 (Spooktacular) 00:26:22 - Scott's 6 (Solar Gardens) 00:27:52 - Jason's 6 (Unstoppable) 00:29:44 - Mark's 6 (Four Doors) 00:31:30 - Scott's 5 (Petiquette) 00:33:43 - Jason's 5 (Grand Central Skyport) 00:36:20 - Mark's 5 (Pillars of Heracles) 00:37:34 - Scott's 4 (Digit Code) 00:39:26 - Jason's 4 (Journey to Tir na Nog, Blessings and Burdens) 00:40:59 - Mark's 4 (12 Rivers) 00:42:53 - Scott's 3 (Temple Code) 00:44:47 - Jason's 3 (Pillars of Fate) 00:46:05 - Mark's 3 (How to Save a World) 00:48:15 - Scott's 2 (Kronologic: Cuzco 1450) 00:50:44 - Jason's 2 (Dark Quarter) 00:52:25 - Mark's 2 (Iliad) 00:54:30 - Scott's 1 (FlipToons) 00:58:00 - Jason's 1 (Vantage) 01:01:20 - Mark's 1 (Timber Town) 01:03:38 - Final Thoughts 01:05:39 - Outro --- Notes! 1) Mark failed to actually say the name of his number nine. The game being discussed is "Escape from the Moon". 2) Scott failed to correctly say the name of his number eight! We were on fire at this point, but in our defense it was almost 2am when we started recording all this! His number eight is actually Gibberers from Hobby Japan. 3) Mark has since played Zenith. IT'S SO, SO GOOD GUYS. 4) We've gotten some preview copies of Pillars of Fate and the other retail IV games that you'll be getting reviews of VERY SHORTLY. Mark likes Pillars A LOT. It's a good thing too, because he's gotta pick up the copy he already bought! --- You can email us at boardallthetimegaming@gmail.com. We can be found at www.boardallthetime.com and on Facebook at Board All The Time. We're on BlueSky now and loving it! At this point it really feels like BlueSky is for board gaming, so definitely check us out on there at https://bsky.app/profile/boardallthetime.bsky.social If you'd like to help support the show and assist with the hosting costs, you can do so with our Ko-Fi: https://ko-fi.com/boardallthetime Our Discord server, which is still in Beta, can be joined at https://discord.gg/VbRWEpc6 We'd like to thank our sponsors as well: Robin's Nerd Supply: www.robinsnerdsupply.com Eco Owl Press: www.ecoowlpress.com We'd also like to thank SoulProdMusic for the intro/outro music.
In this episode, we revisit Alexa Plus and explore its Beta features. We introduce a new concept called Temporary Routines and examine a revised tool forthe blind and visually impaired called Show and Tell. And boy, oh boy! It's a lot snappier!
En este episodio exploramos el nacimiento de la generación beta y el mundo que heredarán enfrentando más de 20 escenarios inevitables: longevidad extrema, ciudades hipervigiladas, economía post-dinero y vínculos emocionales con inteligencias artificiales. Reflexionamos también sobre la gran desconexión: el trabajo ya no garantiza progreso, y la IA está redistribuyendo habilidades y riqueza de forma desigual. Además, analizamos el auge de los mercados bursátiles en plena fiebre por la inteligencia artificial y lanzamos una nueva sección: Startups para el Futuro, con ideas de negocio diseñadas para lo que viene. Learn more about your ad choices. Visit megaphone.fm/adchoices
Go to http://factormeals.com/kindafunny50off and use code kindafunny50off to get 50 percent off plus FREE shipping on your first box Go to https://mood.com and use code KINDAFUNNY to get 20% off your first order. Outer Worlds 2 has received a price drop, Splitgate 2 gets pulled back into Beta, and Nintendo Switch 2 is officially the fastest selling gaming hardware in US history. Thank you for the support! Run of Show - - Start - Housekeeping Today after, KFGD, you'll get: If you're a Kinda Funny Member: The Roper Report - - Microsoft has reversed plans to charge $80 for The Outer Worlds 2 - Splitgate 2 Developer 1047 Games Announces Layoffs, Shuts Down Original Game - Ad - The Nintendo Switch 2 Is the Fastest-Selling Gaming Hardware in U.S. History - New Report Says Xbox's ‘Fable' May Not Release Until 2027 - Super Mario Party Jamboree - Nintendo Switch 2 Edition + Jamboree TV Review Round Up - Capcom Is Once Again Remaking Resident Evil 2 - Wee News! - SuperChats & You‘re Wrong Learn more about your ad choices. Visit megaphone.fm/adchoices
Microsoft finally kills Movies & TV show service in the Microsoft Store. This was the final vestigial minder of Zune that remained. There was Groove Video and Xbox Video, too. Microsoft previously killed eBook (2019) and music (2017) sales. At this point, you would have to be insane to buy content from Microsoft, sorry... but you can get to some of your content on other services via Movies Anywhere - and use the Movies & TV app for now in Windows, which is no longer bundled. Windows 11 It's Week D and you can't tell your Copilot+ PC features from your Windows 11 features without a scorecard A peek at next month's Patch Tuesday - Also, preview updates for 23H2, Windows 10 Copilot+ PCs only: Settings agent, Click to Do improvements, Photo relight in Photos app, Sticker generator and Object select in Paint Everyone: Copilot Vision (U.S. only) in Copilot, Edge Game Assist, Quick Machine Recovery Microsoft explains how PC transfer feature will work in Windows Backup later this year Describe image action for Click to Do (for AMD/Intel), image descriptions in Narrator (AMD/Intel), performance log improvements (!), Click to Do search bar test, Lock screen improvements, privacy improvements head to Dev and Beta channels Bug fixes in Canary, back to the usual waste of time Brave will automatically block Recall WhatsApp is going PWA, killing UWP app Focusrite finally releases drivers for Windows 11 on Arm/Snapdragon X, removing the final major compatibility issue on that platform Linux (sort of) crosses the 5 percent usage milestone Surface/Copilot+ PC Copilot+ PC is a failure as a brand because Microsoft focused on negligible on-device AI features It should have pushed reliability, performance, efficiency and battery life All Copilot+ PC features should come to at least those with GPUs, but really all customers Microsoft failed at AI, and failed with consumers, and so now it's going to tell us what consumers want from AI - a comedy Microsoft announces Surface Laptop for Business with 5G but the real "with" is Intel Inside Intel layoffs are even worse than expected and more are coming Microsoft has a problem and it starts with "C" and ends with "opilot" Microsoft SharePoint has a notably bad security flaw DuckDuckGo adds some neat customization features to Duck.ai and DuckDuckGo lets you hide all AI from search Xbox and gaming The Xbox platform unification continues: Xbox now testing cross-device play history - Not just console games on console, PC games on PC Just kidding! The Outer Worlds will cost $69.99, not $79.99 Tips & Picks Tip of the week: You hate Big Tech, but who can you trust? App pick of the week: Proton Lumo RunAs Radio this week: Copilot Studio with April Dunnam Brown liquor pick of the week: Benromach 10 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: threatlocker.com/twit 1password.com/windowsweekly
Listen to a recap of the top stories of the day from 9to5Mac. 9to5Mac Daily is available on iTunes and Apple's Podcasts app, Stitcher, TuneIn, Google Play, or through our dedicated RSS feed for Overcast and other podcast players. Sponsored by Bitwarden: Check out Bitwarden Password Manager, featuring a new Apple Watch authenticator integration, secure autofill on Safari and iOS apps, and enterprise-grade security tools that help you manage credentials with confidence. New episodes of 9to5Mac Daily are recorded every weekday. Subscribe to our podcast in Apple Podcast or your favorite podcast player to guarantee new episodes are delivered as soon as they're available. Stories discussed in this episode: Report: EU set to accept Apple's latest App Store rules under the DMA iOS 26 beta 4 changes iOS 26 beta 4 adds more ‘liquid' back to Liquid Glass design iOS 26 beta 4 adds new Dynamic option for iPhone wallpaper iOS 26 beta 4 re-enables Apple Intelligence notification summaries for news apps Apple now gives you four years to add AppleCare+ coverage to iPhone and more Apple announces AppleCare One multi-device bundle with simplified pricing AppleCare+ Theft and Loss coverage no longer limited to iPhone Listen & Subscribe: Apple Podcasts Overcast RSS Spotify TuneIn Google Podcasts Subscribe to support Chance directly with 9to5Mac Daily Plus and unlock: Ad-free versions of every episode Bonus content Catch up on 9to5Mac Daily episodes! Don't miss out on our other daily podcasts: Quick Charge 9to5Toys Daily Share your thoughts! Drop us a line at happyhour@9to5mac.com. You can also rate us in Apple Podcasts or recommend us in Overcast to help more people discover the show.
Microsoft finally kills Movies & TV show service in the Microsoft Store. This was the final vestigial minder of Zune that remained. There was Groove Video and Xbox Video, too. Microsoft previously killed eBook (2019) and music (2017) sales. At this point, you would have to be insane to buy content from Microsoft, sorry... but you can get to some of your content on other services via Movies Anywhere - and use the Movies & TV app for now in Windows, which is no longer bundled. Windows 11 It's Week D and you can't tell your Copilot+ PC features from your Windows 11 features without a scorecard A peek at next month's Patch Tuesday - Also, preview updates for 23H2, Windows 10 Copilot+ PCs only: Settings agent, Click to Do improvements, Photo relight in Photos app, Sticker generator and Object select in Paint Everyone: Copilot Vision (U.S. only) in Copilot, Edge Game Assist, Quick Machine Recovery Microsoft explains how PC transfer feature will work in Windows Backup later this year Describe image action for Click to Do (for AMD/Intel), image descriptions in Narrator (AMD/Intel), performance log improvements (!), Click to Do search bar test, Lock screen improvements, privacy improvements head to Dev and Beta channels Bug fixes in Canary, back to the usual waste of time Brave will automatically block Recall WhatsApp is going PWA, killing UWP app Focusrite finally releases drivers for Windows 11 on Arm/Snapdragon X, removing the final major compatibility issue on that platform Linux (sort of) crosses the 5 percent usage milestone Surface/Copilot+ PC Copilot+ PC is a failure as a brand because Microsoft focused on negligible on-device AI features It should have pushed reliability, performance, efficiency and battery life All Copilot+ PC features should come to at least those with GPUs, but really all customers Microsoft failed at AI, and failed with consumers, and so now it's going to tell us what consumers want from AI - a comedy Microsoft announces Surface Laptop for Business with 5G but the real "with" is Intel Inside Intel layoffs are even worse than expected and more are coming Microsoft has a problem and it starts with "C" and ends with "opilot" Microsoft SharePoint has a notably bad security flaw DuckDuckGo adds some neat customization features to Duck.ai and DuckDuckGo lets you hide all AI from search Xbox and gaming The Xbox platform unification continues: Xbox now testing cross-device play history - Not just console games on console, PC games on PC Just kidding! The Outer Worlds will cost $69.99, not $79.99 Tips & Picks Tip of the week: You hate Big Tech, but who can you trust? App pick of the week: Proton Lumo RunAs Radio this week: Copilot Studio with April Dunnam Brown liquor pick of the week: Benromach 10 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: threatlocker.com/twit 1password.com/windowsweekly
Microsoft finally kills Movies & TV show service in the Microsoft Store. This was the final vestigial minder of Zune that remained. There was Groove Video and Xbox Video, too. Microsoft previously killed eBook (2019) and music (2017) sales. At this point, you would have to be insane to buy content from Microsoft, sorry... but you can get to some of your content on other services via Movies Anywhere - and use the Movies & TV app for now in Windows, which is no longer bundled. Windows 11 It's Week D and you can't tell your Copilot+ PC features from your Windows 11 features without a scorecard A peek at next month's Patch Tuesday - Also, preview updates for 23H2, Windows 10 Copilot+ PCs only: Settings agent, Click to Do improvements, Photo relight in Photos app, Sticker generator and Object select in Paint Everyone: Copilot Vision (U.S. only) in Copilot, Edge Game Assist, Quick Machine Recovery Microsoft explains how PC transfer feature will work in Windows Backup later this year Describe image action for Click to Do (for AMD/Intel), image descriptions in Narrator (AMD/Intel), performance log improvements (!), Click to Do search bar test, Lock screen improvements, privacy improvements head to Dev and Beta channels Bug fixes in Canary, back to the usual waste of time Brave will automatically block Recall WhatsApp is going PWA, killing UWP app Focusrite finally releases drivers for Windows 11 on Arm/Snapdragon X, removing the final major compatibility issue on that platform Linux (sort of) crosses the 5 percent usage milestone Surface/Copilot+ PC Copilot+ PC is a failure as a brand because Microsoft focused on negligible on-device AI features It should have pushed reliability, performance, efficiency and battery life All Copilot+ PC features should come to at least those with GPUs, but really all customers Microsoft failed at AI, and failed with consumers, and so now it's going to tell us what consumers want from AI - a comedy Microsoft announces Surface Laptop for Business with 5G but the real "with" is Intel Inside Intel layoffs are even worse than expected and more are coming Microsoft has a problem and it starts with "C" and ends with "opilot" Microsoft SharePoint has a notably bad security flaw DuckDuckGo adds some neat customization features to Duck.ai and DuckDuckGo lets you hide all AI from search Xbox and gaming The Xbox platform unification continues: Xbox now testing cross-device play history - Not just console games on console, PC games on PC Just kidding! The Outer Worlds will cost $69.99, not $79.99 Tips & Picks Tip of the week: You hate Big Tech, but who can you trust? App pick of the week: Proton Lumo RunAs Radio this week: Copilot Studio with April Dunnam Brown liquor pick of the week: Benromach 10 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: threatlocker.com/twit 1password.com/windowsweekly
Microsoft finally kills Movies & TV show service in the Microsoft Store. This was the final vestigial minder of Zune that remained. There was Groove Video and Xbox Video, too. Microsoft previously killed eBook (2019) and music (2017) sales. At this point, you would have to be insane to buy content from Microsoft, sorry... but you can get to some of your content on other services via Movies Anywhere - and use the Movies & TV app for now in Windows, which is no longer bundled. Windows 11 It's Week D and you can't tell your Copilot+ PC features from your Windows 11 features without a scorecard A peek at next month's Patch Tuesday - Also, preview updates for 23H2, Windows 10 Copilot+ PCs only: Settings agent, Click to Do improvements, Photo relight in Photos app, Sticker generator and Object select in Paint Everyone: Copilot Vision (U.S. only) in Copilot, Edge Game Assist, Quick Machine Recovery Microsoft explains how PC transfer feature will work in Windows Backup later this year Describe image action for Click to Do (for AMD/Intel), image descriptions in Narrator (AMD/Intel), performance log improvements (!), Click to Do search bar test, Lock screen improvements, privacy improvements head to Dev and Beta channels Bug fixes in Canary, back to the usual waste of time Brave will automatically block Recall WhatsApp is going PWA, killing UWP app Focusrite finally releases drivers for Windows 11 on Arm/Snapdragon X, removing the final major compatibility issue on that platform Linux (sort of) crosses the 5 percent usage milestone Surface/Copilot+ PC Copilot+ PC is a failure as a brand because Microsoft focused on negligible on-device AI features It should have pushed reliability, performance, efficiency and battery life All Copilot+ PC features should come to at least those with GPUs, but really all customers Microsoft failed at AI, and failed with consumers, and so now it's going to tell us what consumers want from AI - a comedy Microsoft announces Surface Laptop for Business with 5G but the real "with" is Intel Inside Intel layoffs are even worse than expected and more are coming Microsoft has a problem and it starts with "C" and ends with "opilot" Microsoft SharePoint has a notably bad security flaw DuckDuckGo adds some neat customization features to Duck.ai and DuckDuckGo lets you hide all AI from search Xbox and gaming The Xbox platform unification continues: Xbox now testing cross-device play history - Not just console games on console, PC games on PC Just kidding! The Outer Worlds will cost $69.99, not $79.99 Tips & Picks Tip of the week: You hate Big Tech, but who can you trust? App pick of the week: Proton Lumo RunAs Radio this week: Copilot Studio with April Dunnam Brown liquor pick of the week: Benromach 10 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: threatlocker.com/twit 1password.com/windowsweekly
Marty discusses what is really inside the Vision OS 26 developer beta 4 for developers and AVP users. Developer Notes for visionOS 26 Beta 4https://developer.apple.com/documentation/visionos-release-notes/visionos-26-release-notes Website: ThePodtalk.NetEmail: ThePodTalkNetwork@gmail.com
Microsoft finally kills Movies & TV show service in the Microsoft Store. This was the final vestigial minder of Zune that remained. There was Groove Video and Xbox Video, too. Microsoft previously killed eBook (2019) and music (2017) sales. At this point, you would have to be insane to buy content from Microsoft, sorry... but you can get to some of your content on other services via Movies Anywhere - and use the Movies & TV app for now in Windows, which is no longer bundled. Windows 11 It's Week D and you can't tell your Copilot+ PC features from your Windows 11 features without a scorecard A peek at next month's Patch Tuesday - Also, preview updates for 23H2, Windows 10 Copilot+ PCs only: Settings agent, Click to Do improvements, Photo relight in Photos app, Sticker generator and Object select in Paint Everyone: Copilot Vision (U.S. only) in Copilot, Edge Game Assist, Quick Machine Recovery Microsoft explains how PC transfer feature will work in Windows Backup later this year Describe image action for Click to Do (for AMD/Intel), image descriptions in Narrator (AMD/Intel), performance log improvements (!), Click to Do search bar test, Lock screen improvements, privacy improvements head to Dev and Beta channels Bug fixes in Canary, back to the usual waste of time Brave will automatically block Recall WhatsApp is going PWA, killing UWP app Focusrite finally releases drivers for Windows 11 on Arm/Snapdragon X, removing the final major compatibility issue on that platform Linux (sort of) crosses the 5 percent usage milestone Surface/Copilot+ PC Copilot+ PC is a failure as a brand because Microsoft focused on negligible on-device AI features It should have pushed reliability, performance, efficiency and battery life All Copilot+ PC features should come to at least those with GPUs, but really all customers Microsoft failed at AI, and failed with consumers, and so now it's going to tell us what consumers want from AI - a comedy Microsoft announces Surface Laptop for Business with 5G but the real "with" is Intel Inside Intel layoffs are even worse than expected and more are coming Microsoft has a problem and it starts with "C" and ends with "opilot" Microsoft SharePoint has a notably bad security flaw DuckDuckGo adds some neat customization features to Duck.ai and DuckDuckGo lets you hide all AI from search Xbox and gaming The Xbox platform unification continues: Xbox now testing cross-device play history - Not just console games on console, PC games on PC Just kidding! The Outer Worlds will cost $69.99, not $79.99 Tips & Picks Tip of the week: You hate Big Tech, but who can you trust? App pick of the week: Proton Lumo RunAs Radio this week: Copilot Studio with April Dunnam Brown liquor pick of the week: Benromach 10 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Download or subscribe to Windows Weekly at https://twit.tv/shows/windows-weekly Check out Paul's blog at thurrott.com The Windows Weekly theme music is courtesy of Carl Franklin. Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free shows, a members-only Discord, and behind-the-scenes access. Join today: https://twit.tv/clubtwit Sponsors: threatlocker.com/twit 1password.com/windowsweekly
Atrás quedaron los X, los Z, los millenials... ahora llegó el turno de los Beta, los humnos que crecerán en un mundo comandado por la tecnología y la Inteligencia Artificial. Mantente al día con los últimos de 'El Bueno, la Mala y el Feo'. ¡Suscríbete para no perderte ningún episodio!Ayúdanos a crecer dejándonos un review ¡Tu opinión es muy importante para nosotros!¿Conoces a alguien que amaría este episodio? ¡Compárteselo por WhatsApp, por texto, por Facebook, y ayúdanos a correr la voz!Escúchanos en Uforia App, Apple Podcasts, Spotify, y el canal de YouTube de Uforia Podcasts, o donde sea que escuchas tus podcasts.'El Bueno, la Mala y el Feo' es un podcast de Uforia Podcasts, la plataforma de audio de TelevisaUnivision.
We're at Beta 3 and at least a third of the way through the beta season. How are things going, what have we discovered so far and what are we still looking to find out? There are also plenty of other things happening in the Mac Admin community - lets talk through some of those things and get excited for what we are able to do now that we couldn't do before! Hosts: Tom Bridge - @tbridge@theinternet.social Marcus Ransom - @marcusransom Selina Ali - LinkedIn Links: https://github.com/headmin/paw-project https://jc0b.computer/posts/munki-mscp-generator https://github.com/gilburns/Intuneomator https://micromdm.io/blog/micromdm-v1-maintenance-mode/ Sponsors: Kandji 1Password Nudge Security Material Security Watchman Monitoring If you're interested in sponsoring the Mac Admins Podcast, please email podcast@macadmins.org for more information. Get the latest about the Mac Admins Podcast, follow us on Twitter! We're @MacAdmPodcast! The Mac Admins Podcast has launched a Patreon Campaign! Our named patrons this month include Weldon Dodd, Damien Barrett, Justin Holt, Chad Swarthout, William Smith, Stephen Weinstein, Seb Nash, Dan McLaughlin, Joe Sfarra, Nate Cinal, Jon Brown, Dan Barker, Tim Perfitt, Ashley MacKinlay, Tobias Linder Philippe Daoust, AJ Potrebka, Adam Burg, & Hamlin Krewson
Andrew Graham likes low-beta stocks right now, encompassing names like Cisco Systems (CSCO), where he likes their innovation and a potential corporate tech cycle. He's also watching Synopsys (SNPS), which he calls “less expensive” than its peers. In energy, he likes EQT (EQT) as a natural gas play. Andrew shares his expectations around the August 1 trade deadline and the 2Q earnings season.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about
Co-hosts Mark Thompson and Steve Little explore how AI-based transcriptions are revolutionizing genealogical research across the industry. They examine FamilySearch's Full-Text Search expansion to over 1.25 billion records and Ancestry's new document transcription tool.The episode features an exclusive interview with David Ouimette from FamilySearch, who reveals how they're making previously unsearchable handwritten documents accessible through AI technology.This week's Tip of the Week demonstrates Dan Maloney's innovative Genealogy Assistant HTR tool for transcribing multiple documents simultaneously.In RapidFire, they discuss Grok 4's anticipated release, Apple's shift to integrate ChatGPT and Claude rather than develop their own AI, and Google Photos' new natural language search capabilities powered by Gemini.Timestamps:In the News:03:23 AI Transcriptions Everywhere: The New Normal in Genealogy25:33 Building AI Apps with ClaudeInterview:29:34 David Ouimette on FamilySearch's AI JourneyRapidFire:49:27 Grok 4 Release Announcement51:35 Apple Pivots to Third-Party AI Integration56:02 Google Photos Adds Natural Language SearchResource LinksExpanded Access to Full-Text Searchhttps://www.familysearch.org/en/blog/full-text-search-experimental-aiAncestry announces the Beta launch of its new document transcription featurehttps://www.ancestry.com/c/ancestry-blog/ancestry-news/document-transcription-featureSnagit Screen Capturehttps://www.techsmith.com/snagitWindows Snipping Toolhttps://support.microsoft.com/en-us/windows/use-snipping-tool-to-capture-screenshots-00246869-1843-655f-f220-97299b865f6bScreenshots or screen recordings on Machttps://support.apple.com/en-hk/guide/mac-help/mh26782/macDan Maloney's AI Handwritten Text Recognition Toolhttps://www.genea.ca/htr-tool/Anthropic: Build and share AI-powered apps with Claudehttps://www.anthropic.com/news/claude-powered-artifactsAnthropic now lets you make apps right from its Claude AI chatbothttps://www.theverge.com/news/693342/anthropic-claude-ai-apps-artifactGrok 4 release livestream on Wednesday at 8pm PThttps://x.com/elonmusk/status/1942325820170907915Elon Musk's AI chatbot Grok launches into antisemitic rant amid updateshttps://www.washingtonpost.com/technology/2025/07/08/elon-musk-grok-ai-antisemitism/Apple's Original AI announcement on June 10, 2024https://www.apple.com/ca/newsroom/2024/06/introducing-apple-intelligence-for-iphone-ipad-and-mac/Apple's Integrates ChatGPT into iPhoneshttps://support.apple.com/en-ca/guide/iphone/iph00fd3c8c2/iosApple Weighs Using Anthropic or OpenAI to Power Siri in Major Reversalhttps://www.bloomberg.com/news/articles/2025-06-30/apple-weighs-replacing-siri-s-ai-llms-with-anthropic-claude-or-openai-chatgptGoogle Resumes Rollout of AI-Based 'Ask Photos' Image Searchhttps://petapixel.com/2025/06/27/google-resumes-rollout-of-ai-based-ask-photos-image-search/Google Product Manager says Ask Photos paused for quality issueshttps://x.com/jamieasp/status/1929895255844745284Ask Photos coming to more Google Photos usershttps://blog.google/products/photos/updates-ask-photos-search/Ask Photos' Original Announcement May 14, 2024https://petapixel.com/2024/05/14/gemini-powered-ask-photos-brings-an-ai-assistant-to-google-photos/TagsArtificial Intelligence, Genealogy, Family History, AI Transcription, FamilySearch, Ancestry, Document Analysis, Handwritten Text Recognition, Full-Text Search, Screen Capture Tools, Natural Language Processing, Machine Learning, OCR Technology, Dan Maloney, Genealogy Assistant, API Keys, Claude AI, Anthropic, Google Photos, Apple Intelligence, Grok AI, David Ouimette, Truth Sets, Research Tools
Welcome to Forever Exiled! In episode 302 we get into the joys of promoting two games, summer heat, pools, lawns, pretend hate...no matter the season in Path of Exile Land, there's always something worth discussing. GGG's getting ready to start their Path 2 promo and Path 1 is in a great state! For those playing 3.26 Secrets of the Atlas, we hope you're having a great time! And same with those in the Beta. Love ya! Thanks for your time each and every week! (00:00:00) Welcome to Forever Exiled(00:02:45) Weekend talk and backyard troubles(00:08:40) What makes a successful podcast intro(00:12:58) Lawn planning and landscaping(00:18:15) Would you eat cereal out of a frisbee?(00:24:11) Kickstarting PoE banter(00:29:20) Zana and game storylines(00:35:17) Trade league experiences(00:40:43) Balancing power in leagues(00:45:56) When mechanics get in the way(00:52:12) Final thoughts and outroForever Exiled Info:www.foreverexiled.comPatreonTwitter @ForeverExiled82Path of Exile WebsiteWrecker of Days Builds ListDiscord...FE Merch StoreFE Nexus Store
Learning to drive isn't a rite of passage anymore. Here's why you should blame automation. Learn more about your ad choices. Visit megaphone.fm/adchoices
If you've ever struggled with chronic stress, poor sleep, anxiety, or burnout—this episode might just change your life. I'm sitting down with Jim Poole, CEO of NuCalm, to explore the groundbreaking neuroacoustic technology that's helping thousands of people around the world reset their nervous systems—without drugs or side effects.Jim explains how NuCalm works at the intersection of physics, mathematics, and neurobiology, using patented algorithms and biosignal processing to guide the brain into states of deep relaxation. We get into how it's used to decelerate brainwave frequencies, balance the autonomic nervous system, and bring the body back into homeostasis. This is next-level nervous system hygiene, backed by clinical research and used by elite athletes, CEOs, Navy SEALs, and trauma survivors alike.We also talk about the physiological mechanics of stress, the importance of vagus nerve stimulation, and why breathwork, cold plunges, and psychedelics often fail to address the chronic baseline tension most of us live with. Jim shares insights on trauma recovery, why traditional talk therapy can fall short, and how we can retrain the brain to unlearn suffering.This conversation was incredibly eye-opening. If you're looking for a safe, effective, and science-backed way to reclaim your mental clarity, energy, and sleep—NuCalm might be the missing link. Visit nucalm.com and use code LUKE for 15% off any subscription for life.DISCLAIMER: This podcast is for educational purposes only and not intended for diagnosing or treating illnesses. The hosts disclaim responsibility for any adverse effects from using the information presented. Consult your healthcare provider before using referenced products. This podcast may include paid endorsements.THIS SHOW IS BROUGHT TO YOU BY:CALROY | Visit calroy.com/luke to get 25% off and free shipping, plus a free bag of their microbiome gum.JUST THRIVE | Head to justthrivehealth.com and use code LUKE20 to save 20%.QUANTUM UPGRADE | Get a 15-day free trial with code LUKE15 at lukestorey.com/quantumupgrade.BLUSHIELD | Use code LUKE to save 10% off your order at lukestorey.com/blushield.MORE ABOUT THIS EPISODE:(00:00:00) Anxiety vs. Fear: How Your Brain Hijacks Your Reality(00:36:50) Commanding Your Mind: From Reaction to Response(00:53:38) Understanding Brainwaves & the Science Behind NuCalm(01:29:19) The Genius Behind the Music: Inside the Art & Science of NuCalm(01:50:17) Hacking Focus & Energy: NuCalm's Beta & Gamma Brainwave Tracks Explained(02:08:29) Flow State, Frequency, & Letting Go of Meditation ShameResources:• Website: nucalm.com • Instagram: instagram.com/nucalm_official • Facebook: facebook.com/NuCalm • X: