Podcasts about Beta

Thu, 18 Dec 2025 22:45:00 GMT http://relay.fm/connected/583 http://relay.fm/connected/583 The 2025 Annies 583 Federico Viticci, Stephen Hackett, and Myke Hurley The year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. The year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. clean 6789 Subtitle: We Swam Hundreds of MilesThe year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. This episode of Connected is sponsored by: Ecamm: Powerful live streaming platform for Mac. Get a free month with code connected. Squarespace: Save 10% off your first purchase of a website or domain using code CONNECTED. Links and Show Notes: Get Connected Pro: Preshow, postshow, no ads. Submit Feedback Give the Gift of Relay The Ticci Scale Quokka - Wikipedia Opossum - Wikipedia Four Winners and Losers of Apple's 2025 - 512 Pixels Nintendo Switch 2 – First-look trailer - YouTube A New Look for 2025 and Beyond — Relay Why everyone is freaking out about DeepSeek | The Verge Apple Intelligence summaries might get warning labels. That's not enough. – Six Colors TikTok is partially back online in the US, but it's not back in the App Store yet | The Verge Trump signs order refusing to enforce TikTok ban for 75 days | The Verge This is the Samsung Galaxy S25 Edge | The Verge Tech billionaires Bezos and Zuckerberg attend Trump inauguration - BBC News Apple Enlists Company Veteran Kim Vorrath to Help Fix AI, Siri - Bloomberg UK government demands access to Apple users' encrypted data - BBC News Apple's Invites invites you to send invitations – Six Colors Netflix says its brief Apple TV app integration was a mistake | The Verge Sophia Hurley. Born Feb 22, 2025 – Instagram Apple will spend more than $500 billion in the U.S. over the next four years - Apple Some first thoughts about the iPhone 16e – Six Colors Apple buys Intel's modem business for $1B – here's why – Six Colors Daring Fireball: Apple Is Delaying the ‘More Personalized Siri' Apple Intelligence Features Daring Fireball: Something Is Rotten in the State of Cupertino New Mac Studio spans the generations with M4 Max, M3 Ultra chips – Six Colors Apple did what NVIDIA wouldn't - YouTubeA look at chaining Mac Studios together for running AI models. M4 MacBook Air review: Am I blue? – Six Colors Apple updates iPad Air and iPad, revamps Magic Keyboard for iPad Air – Six Colors Apple's Siri Chief Calls AI Delays Ugly and Embarrassing, Promises Fixes - Bloomberg Apple Vision Pro Chief Mike Rockwell Named Siri Head; Giannandrea Keeps AI Role - Bloomberg EU Fines Apple €500 Million for Digital Markets Act Violations - MacStories Updates for apps in the European Union - Latest News - Apple Developer Trade, Tariffs, and Tech – Stratechery by Ben Thompson A judge just blew up Apple's control of the App Store | The Verge Apple files appeal to wrest back control of its App Store | The Verge Apple updates App Store Guidelines to allow links to external payments - 9to5Mac “Apple is fully capable of resolving this issue without further briefing or a hearing.” | The Verge Apple's Eddy Cue: ‘You may not need an iPhone 10 years from now' | The Verge Apple rolls out rebranded “CarPlay Ultra” three years after its unveiling – Six Colors A letter from Sam & Jony | OpenAI OpenAI to Buy Apple Veteran Jony Ive's AI Device Startup in $6.5 Billion Deal - Bloomberg Connected #553: We Have Jony Ive at Home - Relay From the Creators of Shortcuts, Sky Extends AI Integration and Automation to Your Entire Mac - MacStories WWDC25 - Apple Developer Interview: Craig Federighi Opens Up About iPadOS, Its Multitasking Journey, and the iPad's Essence - MacStories WWDC25: macOS Tahoe Breaks Decades of Finder History - 512 Pixels macOS Tahoe Beta 2 Fixes the Finder Icon - 512 Pixels Apple Debates a Deal With Perplexity in Pursuit of AI Talent - Bloomberg New MacBook With A18 Pro Chip Spotted in Apple Code - MacRumors Box Office: 'F1' $144 Million Opening, Apple & Brad Pitt Record; 'M3GAN 2.0' Bombs 'F1' Overtakes 'Napoleon' as Apple's Highest-Grossing Film – Variety Apple announces chief operating officer transition - Apple Meta Hires Apple Top AI Models Executive - Bloomberg Apple expands U.S. supply chain with $500 million commitment - Apple Apple sues leaker Jon Prosser for stealing iOS secrets | The Verge Ted Lasso' Season 4 Cast Set As Production Begins: First Photo – Deadline iOS 26 beta 4 adds more ‘liquid' back to Liquid Glass design - 9to5Mac Apple shipped its 3 billionth iPhone | The Verge Apple increases U.S. commitment to $600 billion, announces ambitious program - Apple Apple made a 24k gold and glass statue for Donald Trump | The Verge Apple launching ‘redesigned Blood Oxygen feature' on Apple Watch in the U.S. today - 9to5Mac UK drops demand for backdoor into Apple encryption | The Verge September 2025 Event Archives - MacStories We Tried to Break the iPhone Air | Interview with Apple's Joz & John Ternus - YouTube iPhone Air Durability test -- I AM SHOCKED - YouTube Google and Apple's $20 billion search deal survives | The Verge Instagram Launches an iPad App - MacStories Relay for St. Jude 2025: $753,756 Raised - 512 Pixels $753,756 - The Enthusiast Apple's ICEblock capitulation is business as usual – Six Colors UK government resumes row with Apple by demanding access to British users' data | Data protection | The Guardian Immersive live NBA games coming to Vision Pro – Six Colors iPadOS 26.1 beta brings back Slide Over, adds microphone adjustments – Six Colors Apple Reorganization: Services Gets Health, Fitness; WatchOS to Craig Federighi - Bloomberg M5 MacBook Pro review: The ultimate computer? – Six Colors M5 iPad Pro Review: An AI and Gaming Upgrade for AI and Games That Aren't There Yet - MacStories M5 Vision Pro, Dual Knit Band, PSVR2 controller review: Apple's experiment continues – Six Colors Apple is the exclusive new broadcast partner for Formula 1® in the U.S. - Apple Jon Prosser says he's been in ‘active communication' with Apple over lawsuit | The Verge Apple Said to Cut iPhone Air Production Amid Underwhelming Sales - MacRumors iOS 26.1 Beta 4 Lets Users Control Liquid Glass Transparency with New Toggle - MacRumors This is just the beginning. - YouTube Daring Fireball: Apple TV's New Fanfare Building Apple TV's New Logo | TBWAMedia Arts Lab Major League Soccer is coming to Apple TV starting in 2026 - Apple Introducing iPhone Pocket: a beautiful way to wear and carry iPhone - Apple Apple hit with $634 million verdict in Apple Watch patent fight with Masimo - 9to5Mac Apple intensifies succession planning for CEO Tim Cook – FT Daring Fireball: Financial Times: 'Apple Intensifies Succession Planning for CEO Tim Cook' Google cracked Apple's AirDrop and is adding it to Pixel phones | The Verge Use Quick Share on your Android device - Android Help Apple might turn to Intel for its upcoming M-series chips, per report - 9to5Mac Apple Fitness+ expands to 28 new markets - Apple Apple's Top Designer Alan Dye Poached by Meta in Major Coup - Bloomberg John Giannandrea to retire from Apple - Apple Apple announces executive transitions - Apple Apple Chip Chief Tells Staff He's Not Leaving ‘Anytime Soon' - Bloomberg Apple announces changes to iOS in Japan - Apple Apple Music in ChatGPT – Viticci – Bluesky

Tony Yacenda https://www.imdb.com/name/nm2829241/ , the director from "Chad Powers", "Dave", "American Vandal", and a ton of commercials, joins Oren and Matt. And in this episode, Tony gives us a look into how he jumped like four levels to get his first big break on American Vandal.Then Matt and Oren get Tony to share what it means to rebalance how you think about your role and what makes you an effective team player. Why? Because what you think is right can be a lot different on a show with higher network exposure and increased performance pressure. Wanna sneak-peak? Have the confidence to do your role really well, and care less about how it impacts other people's jobs. Without being an a**hole.Finally, the three share strategies for being an artist who takes every note, without robotically being a yes-man and without sacrificing the cohesiveness of your creative vision. It's a great episode that may flip how you think about directing. And it just may help you skip levels in your career as a director.Find Tony on Instagram @tyacenda---Help our Patreon! https://www.patreon.com/JustShootItPodMatt's Endorsement: "Paddington 2", the movie https://www.imdb.com/title/tt4468740/ , Flavacol, flavoring for popcorn, and Wonder Boom bluetooth speaker https://www.ultimateears.com/en-us/shop/p/wonderboom-4Oren's Endorsement: Genius Scan pdf scanning app https://help.geniusscan.com/ Also Premiere Pro has a one-click tool to object mask, in the Beta app.Tony's Endorsment: "Going Dutch", the TV show on FOX. And watch it TV-TV, cable or antenna. Hosted on Acast. See acast.com/privacy for more information.

The Black Company Roleplaying Game is a fast-paced, deadly game of swords, sorcery, and soldiers, based on the novel series by Glen Cook. The all-too-mortal soldiers of the Black Company fight and die for an Empire ruled by wicked sorcerers with the powers of gods. In the city of Beryl, a squad of soldiers is sent out on a special mission... Learn more about the Black Company RPG on its website! Note that this was played with an earlier draft of the beta rules, so game mechanics may have changed by now. Ross as Crabs Ethan as Doorstop Dugal Juicy Garland as Princess Kara as Maude Shane Ivey as the GM

Thu, 18 Dec 2025 22:45:00 GMT http://relay.fm/connected/583 http://relay.fm/connected/583 Federico Viticci, Stephen Hackett, and Myke Hurley The year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. The year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. clean 6789 Subtitle: We Swam Hundreds of MilesThe year is coming to an end, and to celebrate, Federico, Stephen, and Myke score each month with the only unit of measurement that matters: the Ticci Scale. This episode of Connected is sponsored by: Ecamm: Powerful live streaming platform for Mac. Get a free month with code connected. Squarespace: Save 10% off your first purchase of a website or domain using code CONNECTED. Links and Show Notes: Get Connected Pro: Preshow, postshow, no ads. Submit Feedback Give the Gift of Relay The Ticci Scale Quokka - Wikipedia Opossum - Wikipedia Four Winners and Losers of Apple's 2025 - 512 Pixels Nintendo Switch 2 – First-look trailer - YouTube A New Look for 2025 and Beyond — Relay Why everyone is freaking out about DeepSeek | The Verge Apple Intelligence summaries might get warning labels. That's not enough. – Six Colors TikTok is partially back online in the US, but it's not back in the App Store yet | The Verge Trump signs order refusing to enforce TikTok ban for 75 days | The Verge This is the Samsung Galaxy S25 Edge | The Verge Tech billionaires Bezos and Zuckerberg attend Trump inauguration - BBC News Apple Enlists Company Veteran Kim Vorrath to Help Fix AI, Siri - Bloomberg UK government demands access to Apple users' encrypted data - BBC News Apple's Invites invites you to send invitations – Six Colors Netflix says its brief Apple TV app integration was a mistake | The Verge Sophia Hurley. Born Feb 22, 2025 – Instagram Apple will spend more than $500 billion in the U.S. over the next four years - Apple Some first thoughts about the iPhone 16e – Six Colors Apple buys Intel's modem business for $1B – here's why – Six Colors Daring Fireball: Apple Is Delaying the ‘More Personalized Siri' Apple Intelligence Features Daring Fireball: Something Is Rotten in the State of Cupertino New Mac Studio spans the generations with M4 Max, M3 Ultra chips – Six Colors Apple did what NVIDIA wouldn't - YouTubeA look at chaining Mac Studios together for running AI models. M4 MacBook Air review: Am I blue? – Six Colors Apple updates iPad Air and iPad, revamps Magic Keyboard for iPad Air – Six Colors Apple's Siri Chief Calls AI Delays Ugly and Embarrassing, Promises Fixes - Bloomberg Apple Vision Pro Chief Mike Rockwell Named Siri Head; Giannandrea Keeps AI Role - Bloomberg EU Fines Apple €500 Million for Digital Markets Act Violations - MacStories Updates for apps in the European Union - Latest News - Apple Developer Trade, Tariffs, and Tech – Stratechery by Ben Thompson A judge just blew up Apple's control of the App Store | The Verge Apple files appeal to wrest back control of its App Store | The Verge Apple updates App Store Guidelines to allow links to external payments - 9to5Mac “Apple is fully capable of resolving this issue without further briefing or a hearing.” | The Verge Apple's Eddy Cue: ‘You may not need an iPhone 10 years from now' | The Verge Apple rolls out rebranded “CarPlay Ultra” three years after its unveiling – Six Colors A letter from Sam & Jony | OpenAI OpenAI to Buy Apple Veteran Jony Ive's AI Device Startup in $6.5 Billion Deal - Bloomberg Connected #553: We Have Jony Ive at Home - Relay From the Creators of Shortcuts, Sky Extends AI Integration and Automation to Your Entire Mac - MacStories WWDC25 - Apple Developer Interview: Craig Federighi Opens Up About iPadOS, Its Multitasking Journey, and the iPad's Essence - MacStories WWDC25: macOS Tahoe Breaks Decades of Finder History - 512 Pixels macOS Tahoe Beta 2 Fixes the Finder Icon - 512 Pixels Apple Debates a Deal With Perplexity in Pursuit of AI Talent - Bloomberg New MacBook With A18 Pro Chip Spotted in Apple Code - MacRumors Box Office: 'F1' $144 Million Opening, Apple & Brad Pitt Record; 'M3GAN 2.0' Bombs 'F1' Overtakes 'Napoleon' as Apple's Highest-Grossing Film – Variety Apple announces chief operating officer transition - Apple Meta Hires Apple Top AI Models Executive - Bloomberg Apple expands U.S. supply chain with $500 million commitment - Apple Apple sues leaker Jon Prosser for stealing iOS secrets | The Verge Ted Lasso' Season 4 Cast Set As Production Begins: First Photo – Deadline iOS 26 beta 4 adds more ‘liquid' back to Liquid Glass design - 9to5Mac Apple shipped its 3 billionth iPhone | The Verge Apple increases U.S. commitment to $600 billion, announces ambitious program - Apple Apple made a 24k gold and glass statue for Donald Trump | The Verge Apple launching ‘redesigned Blood Oxygen feature' on Apple Watch in the U.S. today - 9to5Mac UK drops demand for backdoor into Apple encryption | The Verge September 2025 Event Archives - MacStories We Tried to Break the iPhone Air | Interview with Apple's Joz & John Ternus - YouTube iPhone Air Durability test -- I AM SHOCKED - YouTube Google and Apple's $20 billion search deal survives | The Verge Instagram Launches an iPad App - MacStories Relay for St. Jude 2025: $753,756 Raised - 512 Pixels $753,756 - The Enthusiast Apple's ICEblock capitulation is business as usual – Six Colors UK government resumes row with Apple by demanding access to British users' data | Data protection | The Guardian Immersive live NBA games coming to Vision Pro – Six Colors iPadOS 26.1 beta brings back Slide Over, adds microphone adjustments – Six Colors Apple Reorganization: Services Gets Health, Fitness; WatchOS to Craig Federighi - Bloomberg M5 MacBook Pro review: The ultimate computer? – Six Colors M5 iPad Pro Review: An AI and Gaming Upgrade for AI and Games That Aren't There Yet - MacStories M5 Vision Pro, Dual Knit Band, PSVR2 controller review: Apple's experiment continues – Six Colors Apple is the exclusive new broadcast partner for Formula 1® in the U.S. - Apple Jon Prosser says he's been in ‘active communication' with Apple over lawsuit | The Verge Apple Said to Cut iPhone Air Production Amid Underwhelming Sales - MacRumors iOS 26.1 Beta 4 Lets Users Control Liquid Glass Transparency with New Toggle - MacRumors This is just the beginning. - YouTube Daring Fireball: Apple TV's New Fanfare Building Apple TV's New Logo | TBWAMedia Arts Lab Major League Soccer is coming to Apple TV starting in 2026 - Apple Introducing iPhone Pocket: a beautiful way to wear and carry iPhone - Apple Apple hit with $634 million verdict in Apple Watch patent fight with Masimo - 9to5Mac Apple intensifies succession planning for CEO Tim Cook – FT Daring Fireball: Financial Times: 'Apple Intensifies Succession Planning for CEO Tim Cook' Google cracked Apple's AirDrop and is adding it to Pixel phones | The Verge Use Quick Share on your Android device - Android Help Apple might turn to Intel for its upcoming M-series chips, per report - 9to5Mac Apple Fitness+ expands to 28 new markets - Apple Apple's Top Designer Alan Dye Poached by Meta in Major Coup - Bloomberg John Giannandrea to retire from Apple - Apple Apple announces executive transitions - Apple Apple Chip Chief Tells Staff He's Not Leaving ‘Anytime Soon' - Bloomberg Apple announces changes to iOS in Japan - Apple Apple Music in ChatGPT – Viticci – Bluesky

Are you curious how entrepreneurs manage to sell products before they've even built them? Pre‑selling is the key to validating your idea and getting money in the bank before launch day.In this episode, Omar shares how he pre‑sold his own software to beta customers and the exact steps you can follow too. You'll learn how to craft a no‑brainer offer, build trust, and use risk reversal strategies to land your first paying beta members. He also breaks down four key moves, including how to anchor your price, treat beta users like VIPs, and validate your product before investing years of effort.Hit play at the top of the page and walk away with a clear framework for pre‑selling to your own beta customers and setting your business up for long‑term growth.To submit your questions, visit 100mba.net/q.Watch the episodes on YouTube: https://lm.fm/GgRPPHiSUBSCRIBEYouTube | Apple Podcast | Spotify | Podcast Feed Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Apple lo ha vuelto a hacer. Un iPhone con una versión desconocida de iOS 26 Beta ha llegado a manos privadas y contenía todos los dispositivos que Apple tiene pensado lanzar próximanente. Te lo cuento todo. Además hablamos de las últimas actualizaciones y rumores. Aplicación de la semana: CookNest https://dsh.re/7584b0 Además de las noticias y la opinión acerca de las novedades de la semana, también responderemos a las preguntas de nuestros oyentes. Tendremos durante toda la semana activo en Twitter el hashtag #podcastapple para que nos preguntéis lo que queráis, nos hagáis sugerencias o lo que se os pase por la cabeza. Dudas, tutoriales, opinión y review de aplicaciones, cualquier cosa tiene cabida en esta sección que ocupará la parte final de nuestro podcast y que queremos que nos ayudéis a hacer todas las semanas. Os recordamos que que si queréis formar parte de una de las comunidades más grandes de Apple en español, entréis a nuestra comunidad de Telegram (enlace) donde podréis opinar, preguntar dudas, comentar las noticias, etc. Y aquí no cobramos por entrar, ni te tratamos mejor si pagas. Os recomendamos que os suscribáis en iTunes en iVoox o en Spotify para que los episodios se descarguen de forma automática en cuanto estén disponibles. También puedes escucharlo en Cuonda, tú eliges.

- Apple öffnet Türen: iOS 26.3 startet in die Beta - Giftige Geschenkkarte: Dr. Paris Buttfield-Addison und die Macht der Apple ID - Geht unter die Haut: Großbritannien will Nacktfilter im Betriebssystem - Überfällig oder Käse? Schweiz untersucht Apple Pay - Umfrage der Woche - Zuschriften unserer Hörer === Anzeige / Sponsorenhinweis === Diese Folge wird präsentiert von returnthis. Mit dem kostengünstigen Lost & Found-System kannst Du ohne Abo und App-Download beliebig viele Gegenstände absichern. Mehr Infos und 20 Prozent Rabatt für Apfelfunk-Hörer gibt es unter https://www.returnthis.ch/apfelfunk === Anzeige / Sponsorenhinweis Ende === Links zur Sendung: - 9to5Mac: Was in iOS 26.3 drinsteckt - https://9to5mac.com/2025/12/17/ios-26-3-new-features-for-iphone/ - Apfelfunk: Apple veröffentlicht iOS 26.2 mit Liquid Glass, CarPlay-Optionen und KI-Updates - https://apfelfunk.com/apple-veroeffentlicht-ios-26-2-mit-liquid-glass-carplay-optionen-und-ki-updates/ - Blogbeitrag: Betroffener berichtet über die Sperrung seiner Apple ID - https://hey.paris/posts/appleid/ - Apfelfunk: Britische Regierung will Nacktbilder auf iPhones und Android-Geräten blockieren - https://apfelfunk.com/britische-regierung-will-nacktbilder-auf-iphones-und-android-geraeten-blockieren/ - Mac & i: Schweizer Kartellbehörde prüft Apples NFC-Zugangsbedingungen - https://www.heise.de/news/Schweiz-Kartellbehoerde-prueft-Apples-NFC-Zugangsbedingungen-11114103.html Kapitelmarken: (00:00:00) Begrüßung (00:24:43) Werbung (00:29:33) Begrüßung (00:32:26) Themen (00:33:22) Apple öffnet Türen: iOS 26.3 startet in die Beta (00:45:08) Giftige Geschenkkarte: Dr. Paris Buttfield-Addison und die Macht der Apple ID (01:01:48) Geht unter die Haut: Großbritannien will Nacktfilter im Betriebssystem (01:07:38) Überfällig oder Käse? Schweiz untersucht Apple Pay (01:14:36) Umfrage der Woche (01:16:15) Zuschriften unserer Hörer

On today's EMARKETER Miniseries—A Blueprint to Better Measurement—we explore Amazon's plans for moving out of Beta and offering Omnichannel Metrics (OCM) more widely to advertisers, the top two challenges they face heading into the new year, and what is next for Amazon Ads in 2026, as it pertains to durables. EMARKETER Principal Analyst Sky Canaves speaks with Kolby Capelouto, Head of Sales for Durables at Amazon Ads. Listen everywhere you find podcasts, and watch on YouTube and Spotify.   To learn more about our research and get access to PRO+ go to EMARKETER.com   Follow us on Instagram at: https://www.instagram.com/emarketer/ For sponsorship opportunities contact us: advertising@emarketer.com For more information visit: https://www.emarketer.com/advertise/ Have questions or just want to say hi? Drop us a line at podcast@emarketer.com    For a transcript of this episode click here: https://www.emarketer.com/content/podcast-blueprint-better-measurement-part-2-with-amazon-ads-emarketer-miniseries   © 2025 EMARKETER   Amazon Ads offers full-funnel advertising solutions to help businesses of all sizes achieve their marketing goals at scale. Amazon Ads connects advertisers to highly relevant audiences through first-party insights; extensive reach across premium content like Prime Video, Twitch, and third-party publishers; the ability to connect and directly measure campaign tactics across awareness, consideration, and conversion; and generative AI to deliver appropriate creative at each step. Amazon Ads helps advertisers reach an average monthly ad-supported audience of more than 300 million in the U.S. across Amazon's owned and operated properties and third-party publishers. 

Osteomyelitis in children is common enough to miss and serious enough to matter. In this episode of PEM Currents, we review a practical, evidence-based approach to pediatric acute hematogenous osteomyelitis, focusing on diagnostic strategy, imaging decisions including FAST MRI, and modern antibiotic management. Topics include age-based microbiology, empiric and pathogen-directed antibiotic selection with dosing, criteria for early transition to oral therapy, and indications for orthopedic and infectious diseases consultation. Special considerations such as MRSA, Kingella kingae, daycare clustering, and shortened treatment durations are discussed with an emphasis on safe, high-value care. Learning Objectives After listening to this episode, learners will be able to: Identify the key clinical, laboratory, and imaging findings that support the diagnosis of acute hematogenous osteomyelitis in children, including indications for FAST MRI and contrast-enhanced MRI. Select and dose appropriate empiric and pathogen-directed antibiotic regimens for pediatric osteomyelitis based on patient age, illness severity, and local MRSA prevalence, and determine when early transition to oral therapy is appropriate. Determine when consultation with orthopedics and infectious diseases is indicated, and recognize clinical features that warrant prolonged therapy or more conservative management. References Woods CR, Bradley JS, Chatterjee A, et al. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Pediatric Infect Dis Soc. 2021;10(8):801-844. doi:10.1093/jpids/piab027 Woods CR, Bradley JS, Chatterjee A, et al. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2023 guideline on diagnosis and management of acute bacterial arthritis in pediatrics. J Pediatric Infect Dis Soc. 2024;13(1):1-59. doi:10.1093/jpids/piad089 Stephan AM, Platt S, Levine DA, et al. A novel risk score to guide the evaluation of acute hematogenous osteomyelitis in children. Pediatrics. 2024;153(1):e2023063153. doi:10.1542/peds.2023-063153 Alhinai Z, Elahi M, Park S, et al. Prediction of adverse outcomes in pediatric acute hematogenous osteomyelitis. Clin Infect Dis. 2020;71(9):e454-e464. doi:10.1093/cid/ciaa211 Burns JD, Upasani VV, Bastrom TP, et al. Age and C-reactive protein associated with improved tissue pathogen identification in children with blood culture-negative osteomyelitis: results from the CORTICES multicenter database. J Pediatr Orthop. 2023;43(8):e603-e607. doi:10.1097/BPO.0000000000002448 Peltola H, Pääkkönen M. Acute osteomyelitis in children. N Engl J Med. 2014;370(4):352-360. doi:10.1056/NEJMra1213956 Transcript This transcript was provided via use of the Descript AI application Welcome to PEM Currents, the Pediatric Emergency Medicine Podcast. As always, I'm your host, Brad Sobolewski, and today we're covering osteomyelitis in children. We're going to talk about diagnosis and imaging, and then spend most of our time where practice variation still exists: antibiotic selection, dosing, duration, and the evidence supporting early transition to oral therapy. We'll also talk about when to involve orthopedics, infectious diseases, and whether daycare outbreaks of osteomyelitis are actually a thing. So what do I mean by pediatric osteomyelitis? In children, osteomyelitis is most commonly acute hematogenous osteomyelitis. That means bacteria seed the bone via the bloodstream. The metaphysis of long bones is particularly vulnerable due to vascular anatomy that favors bacterial deposition. Age matters. In neonates, transphyseal vessels allow infection to cross into joints, increasing the risk of concomitant septic arthritis. In older children, those vessels involute, and infection tends to remain metaphyseal and confined to bone rather than spreading into the joint. For children three months of age and older, empiric therapy must primarily cover Staphylococcus aureus, which remains the dominant pathogen. Other common organisms include group A streptococcus and Streptococcus pneumoniae. In children six to 36 months of age, especially those in daycare, Kingella kingae is an important and often underrecognized pathogen. Kingella infections are typically milder, may present with lower inflammatory markers, and frequently yield negative routine cultures. Kingella is usually susceptible to beta-lactams like cefazolin, but is consistently resistant to vancomycin and often resistant to clindamycin and antistaphylococcal penicillins. This has direct implications for empiric antibiotic selection. Common clinical features of osteomyelitis include fever, localized bone pain, refusal to bear weight, and pain with movement of an adjacent joint. Fever may be absent early, particularly with less virulent organisms like Kingella. A normal white blood cell count does not exclude osteomyelitis. Only about one-third of children present with leukocytosis. CRP and ESR are generally more useful, particularly CRP for monitoring response to therapy. No single CRP cutoff reliably diagnoses or excludes osteomyelitis in children. While CRP is elevated in most cases of acute hematogenous osteomyelitis, the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America note that high-quality data defining diagnostic thresholds are limited. A CRP above 20 milligrams per liter is commonly used to support clinical suspicion, with pooled sensitivity estimates around 80 to 85 percent, but no definitive value mandates the diagnosis. Lower values do not exclude disease, particularly in young children, as CRP is normal in up to 40 percent of Kingella kingae infections. CRP values tend to be higher in Staphylococcus aureus infections, especially MRSA, and higher levels are associated with complications such as abscess, bacteremia, and thrombosis, though specific cutoffs are not absolute. In summary, CRP is most useful for monitoring treatment response. It typically peaks two to four days after therapy initiation and declines rapidly with effective treatment, with a 50 percent reduction within four days seen in the majority of uncomplicated cases. Blood cultures should be obtained in all children with suspected osteomyelitis, ideally before starting antibiotics when feasible. In children, blood cultures alone can sometimes identify the pathogen. Plain radiographs are still recommended early, not because they're sensitive for acute osteomyelitis, but because they help exclude fracture, malignancy, or foreign body and establish a baseline. MRI with and without contrast is the preferred advanced imaging modality. MRI confirms the diagnosis, defines the extent of disease, and identifies complications such as subperiosteal abscess, physeal involvement, and concomitant septic arthritis. MRI findings can also guide the need for surgical consultation. Many pediatric centers now use FAST MRI protocols for suspected osteomyelitis, particularly from the emergency department. FAST MRI uses a limited sequence set, typically fluid-sensitive sequences like STIR or T2 with fat suppression, without contrast. These studies significantly reduce scan time, often avoid the need for sedation, and retain high sensitivity for bone marrow edema and soft tissue inflammation. FAST MRI is particularly useful when the clinical question is binary: is there osteomyelitis or not? It's most appropriate in stable children without high concern for abscess, multifocal disease, or surgical complications. If FAST MRI is positive, a full contrast-enhanced MRI may still be needed to delineate abscesses, growth plate involvement, or adjacent septic arthritis. If FAST MRI is negative but clinical suspicion remains high, further imaging may still be necessary. The Pediatric Infectious Diseases Society and the Infectious Diseases Society of America recommend empiric antibiotic selection based on regional MRSA prevalence, patient age, and illness severity, with definitive therapy guided by culture results and susceptibilities. Empiric therapy should never be delayed in an ill-appearing or septic child. In well-appearing, stable children, antibiotics may be briefly delayed to obtain imaging or tissue sampling, but this requires close inpatient observation. For children three months and older with non–life-threatening disease, empiric therapy hinges on local MRSA rates. In regions with low community-acquired MRSA prevalence, generally under 10 percent, reasonable empiric options include cefazolin, oxacillin, or nafcillin. When MRSA prevalence exceeds 10 to 20 percent, empiric therapy should include an MRSA-active agent. Clindamycin is appropriate when local resistance rates are low, while vancomycin is preferred when clindamycin resistance is common or the child has had significant healthcare exposure. For children with severe disease or sepsis, vancomycin is generally preferred regardless of local MRSA prevalence. Some experts recommend combining vancomycin with oxacillin or nafcillin to ensure optimal coverage for MSSA, group A streptococcus, and MRSA. In toxin-mediated or high-inoculum infections, the addition of clindamycin may be beneficial due to protein synthesis inhibition. Typical IV dosing includes cefazolin 100 to 150 milligrams per kilogram per day divided every eight hours; oxacillin or nafcillin 150 to 200 milligrams per kilogram per day divided every six hours; clindamycin 30 to 40 milligrams per kilogram per day divided every six to eight hours; and vancomycin 15 milligrams per kilogram every six hours for serious infections, with appropriate monitoring. Ceftaroline or daptomycin may be considered in select MRSA cases when first-line agents are unsuitable. For methicillin-susceptible Staphylococcus aureus, first-generation cephalosporins or antistaphylococcal penicillins remain the preferred parenteral agents. For oral therapy, high-dose cephalexin, 75 to 100 milligrams per kilogram per day divided every six hours, is preferred. Clindamycin is an alternative when beta-lactams cannot be used. For clindamycin-susceptible MRSA, clindamycin is the preferred IV and oral agent due to excellent bioavailability and bone penetration, and it avoids the renal toxicity associated with vancomycin. For clindamycin-resistant MRSA, vancomycin or ceftaroline are preferred IV agents. Oral options are limited, and linezolid is generally the preferred oral agent when transition is possible. Daptomycin may be used parenterally in children older than one year without pulmonary involvement, typically with infectious diseases and pharmacy input. Beta-lactams remain the drugs of choice for Kingella kingae, Streptococcus pyogenes, and Streptococcus pneumoniae. Vancomycin has no activity against Kingella, and clindamycin is often ineffective. For Salmonella osteomyelitis, typically seen in children with sickle cell disease, third-generation cephalosporins or fluoroquinolones are used. In underimmunized children under four years, consider Haemophilus influenzae type b, with therapy guided by beta-lactamase production. Doxycycline has not been prospectively studied in pediatric acute hematogenous osteomyelitis. There are theoretical concerns about reduced activity in infected bone and risks related to prolonged therapy. While short courses are safe for certain infections, the longer durations required for osteomyelitis increase the risk of adverse effects. Doxycycline should be considered only when no other active oral option is available, typically in older children, and with infectious diseases consultation. It is not appropriate for routine treatment. Many hospitals automatically consult orthopedics when children are admitted with osteomyelitis, and this is appropriate. Early orthopedic consultation should be viewed as team-based care, not failure of medical management. Consult orthopedics when MRI shows abscess or extensive disease, there is concern for septic arthritis, the child fails to improve within 48 to 72 hours, imaging suggests devitalized bone or growth plate involvement, there is a pathologic fracture, the patient is a neonate, or diagnostic bone sampling or operative drainage is being considered. Routine surgical debridement is not required for uncomplicated cases. Infectious diseases consultation is also often automatic and supported by guidelines. ID is particularly valuable for antibiotic selection, dosing, IV-to-oral transition, duration decisions, bacteremia management, adverse reactions, and salvage regimens. Even in straightforward cases, ID involvement often facilitates shorter IV courses and earlier oral transition. Osteomyelitis is generally not contagious, and clustering is uncommon for Staphylococcus aureus. Kingella kingae is the key exception. It colonizes the oropharynx of young children and spreads via close contact. Clusters of invasive Kingelladisease have been documented in daycare settings. Suspicion should be higher in children six to 36 months from the same daycare, with recent viral illness, mild systemic symptoms, refusal to bear weight, modest CRP elevation, and negative routine cultures unless PCR testing is used. Public health intervention is not typically required, but awareness is critical. There is no minimum required duration of IV therapy for uncomplicated acute hematogenous osteomyelitis. Transition to oral therapy should be based on clinical improvement plus CRP decline. Many children meet criteria within two to six days. Oral antibiotics must be dosed higher than standard outpatient regimens to ensure adequate bone penetration. Common regimens include high-dose cephalexin, clindamycin, or linezolid in select cases. The oral agent should mirror the IV agent that produced clinical improvement. Total duration is typically three to four weeks, and in many cases 15 to 20 days is sufficient. MRSA infections or complicated cases usually require four to six weeks. Early oral transition yields outcomes comparable to prolonged IV therapy with fewer complications. Most treatment-related complications occur during parenteral therapy, largely due to catheter-related issues. Take-home points: osteomyelitis in children is a clinical diagnosis supported by labs and MRI. Empiric antibiotics should be guided by age, illness severity, and local MRSA prevalence. Early transition to high-dose oral therapy is safe and effective when clinical response and CRP support it. Orthopedics and infectious diseases consultation improve care and reduce variation. FAST MRI is changing how we diagnose osteomyelitis. Daycare clustering is uncommon except with Kingella kingae. That's all for this episode. If there are other topics you'd like us to cover, let me know. If you have the time, leave a review on your favorite podcast platform. It helps more people find the show and learn from it. For PEM Currents, this has been Brad Sobolewski. See you next time.    

Eric, Dave and Marty breakdown the latest VisionOS beta and some really intriguing patents showing directions Apple could go. Dave never had a hamster or a guinea pig. visionOS 26.3 Beta Release Notes https://developer.apple.com/documentation/visionos-release-notes/visionos-26_3-release-notes Apple Releases First watchOS 26.3, tvoS 26.3 and visionOS 26.3 Betashttps://forums.macrumors.com/threads/apple-releases-first-watchos-26-3-tvos-26-3-and-visionos-26-3-betas.2474753/visionOS 26.2 Now Available for Apple Vision Pro Usershttps://www.macobserver.com/news/visionos-26-2-now-available-for-apple-vision-pro-users/ Minor bug fix update for Apple Vision Pro arrives with visionOS 26.2https://appleinsider.com/articles/25/12/12/minor-bug-fix-update-for-apple-vision-pro-arrives-with-visionos-262Is Red Bull's "Immersive" Apple Vision Pro Ski Movie The Future of Action Sports?https://www.powder.com/news/world-of-red-bull-apple-vision-pro-ski-movie Apple Eyes Room-Aware Audio With New Patent Filinghttps://x.com/PatentlyApple/status/2000265846925697290Patent: Next-Gen Apple HMD Design Targets Comfort and Customizationhttps://x.com/PatentlyApple/status/1999503955785572486 Apple Introduces Next-Gen Gaze Tracking for Future Vision Pro and Smartglasseshttps://x.com/PatentlyApple/status/1999932661108801855 Apple Patent Expands Breath Tracking into AR/VR Interfaceshttps://x.com/PatentlyApple/status/1999865437509595198 Reinforced Fit: Apple's reveals Modular, Multi-Axis Band Architecture for next-gen Vision Prohttps://x.com/PatentlyApple/status/1999476174280376735 High-End Hybrid Sensor Approach could Redefine Apple'svGaming Input Strategyhttps://x.com/PatentlyApple/status/1999140661744779334 Grip Aware Pose: Apple's Patent uses Hand Skeletons to Track Hidden Controllershttps://x.com/PatentlyApple/status/1999163040906748278 The AR Glasses Race: Meta Ray-Ban at $299 vs Apple Vision Pro at $3,499 — Who Wins the Next Computing Platform?https://fourweekmba.com/the-ar-glasses-race-meta-ray-ban-at-299-vs-apple-vision-pro-at-3499-who-wins-the-next-computing-platform Vision Pro M5 vs. Meta Quest 3S: Two Very Different Takes on Mixed Realityhttps://www.macobserver.com/tips/round-ups/vision-pro-m5-vs-meta-quest-3s/Vision Pro 2 rumors: is the future of Apple's visionOS tech actually smart glasses?https://www.stuff.tv/features/apple-vision-pro-2/ Review: Samsung Galaxy XRhttps://www.wired.com/review/samsung-galaxy-xr/Samsung Galaxy XR is getting 3 massive upgrades — Apple Vision Pro should be sweatinghttps://www.tomsguide.com/computing/vr-ar/3-new-upgrades-are-coming-to-samsung-galaxy-xr-including-one-of-the-vision-pros-best-featuresCan Apple's Vision Pro Turn the Office Into a Metaverse? - A New Reality for Productivity and Presencehttps://www.prnewsblog.com/tech/24709/can-apples-vision-pro-turn-the-office-into-a-metaverse-a-new-reality-for-productivity-and-presence/ Galaxy XR version of personashttps://www.youtube.com/shorts/qW-HaCNuCzAGravitas Threads: Exploring Reddit as a spatial museum in XR (Vision Pro app) Al + Physics Recommendation Enginehttps://www.reddit.com/r/AR_MR_XR/comments/1pn2f72/gravitas_threads_exploring_reddit_as_a_spatial/ APPS Sunglasses - Night Modehttps://apps.apple.com/us/app/sunglasses-night-mode/id6756418533 Glassbreakers - good use of control options using different fingers or positionshttps://apps.apple.com/us/app/glassbreakers/id6596780523ReminderFollow the live stream at YouTube.com/@VisionProfiles on Monday nights at 9 PM EST or catch the video later on Youtube or audio on any pod catcher serviceWebsite: ThePodTalk.NetEmail: ThePodTalkNetwork@gmail.com 

For this week's episode of the Clinician's Corner, we've gone into the archives to pull out another clinical pearl from one of our favorite episodes - and today we discuss beta glucuronidase and its surprisingly wide-ranging impact on our health (from hormones to gut health and even bone health).   This interview first aired earlier this year (2025), and the full interview can be viewed here.   Clinical pearls we extracted from the original interview: Understanding beta-glucuronidase (what it is and what it does) Challenging established views on beta glucuronidase Hormone-microbiome interactions Beta glucuronidase and GI function Clinical implications for women Gut-healing supplement recommendations  The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   Connect with Dr. Betty Murray: Websites: https://bettymurray.com; https://livingwelldallas.com; ​​and https://getmenrva.com YouTube: https://www.youtube.com/@drbettymurray and https://www.youtube.com/@MenopauseMasteryShow Instagram: https://www.instagram.com/drbettymurray/ Facebook: https://www.facebook.com/drbettymurray LinkedIn: https://www.linkedin.com/in/bettymurray/   Timestamps:  00:00 "Microbiome Shifts with Hormones" 03:15 Microbiome, Hormones, and IBS Connections 06:26 Hormones, IBS, and Menopause Trends 10:21 "Fermented Foods and Intuition" 13:04 Clinician's Corner: Thank You   Speaker bio: Dr. Betty Murray is a women's health advocate, nutrition expert, PhD researcher, certified functional medicine practitioner, author, and speaker. Betty helps women over 40 harness their hormones to lose weight, optimize sleep, restore energy, and thrive. During her research for her Ph.D., Betty made several key discoveries that lead to hormone & metabolic imbalances that plague women over 40. Restoring balance to these key metabolic and hormone pathways is the basis of her Menopause Mastery Program.    Dr. Betty is the founder and CEO of Living Well Dallas Functional Medicine Center and Menrva, a national women's telemedicine company providing bioidentical hormone treatment, nutrition, diet, and lifestyle guidance to feel like perimenopause and menopause never happened. She is the host of the Menopause Mastery Podcast, author, and featured writer for Brainz Magazine. As a professional speaker, she has shared the stage with Lisa Nichols, Dr. Mark Hyman, JJ Virgin, Dr. Steven Gundry, Codie Sanchez, Dr. Shrini Pallay, and many others, and she is a frequently featured nutrition expert on Fox News Broadcasting, CW33, NBC, and CBS.     Keywords: functional health practitioners, beta glucuronidase, gut health, hormones, estrogen metabolism, microbiome, menopause, perimenopause, chronic disease, stool testing, IBS (Irritable Bowel Syndrome), serotonin receptors, neurotransmitters, glucuronidation, prostaglandins, GI motility, hormone cycles, case studies, evidence-based strategies, clinical pearls, hormone receptors, digestive supplements, fermented foods, polyphenols, resistant starches, gut healing protocols, 5R protocol, clinical training, restorative health, women's health Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

✨ A Rhythm for Slowing DownMindfulness, sound healing, and ritual — woven into every frequency. This is a sensory journey curated by interdisciplinary artist and architect of calm, Sya Warfield.Calm isn't something you wait for. It's something you create.Last new moon of the year - Friday, December 19, 2025.Ritual Era Meditation is a 12-week digital experience designed to restore your nervous system, soften your edges, and bring clarity to your inner world. Each week, you'll explore sound frequencies, gentle practices, and grounding rituals — all from the comfort of your own rhythm.Your soft place to return to, anytime:https://studio.com/apps/sya/calm

durée : 00:04:00 - La main verte - par : Alain Baraton - Alain Baraton nous conseille ce matin deux livres : "Insectes" de Bruno Didier et Nicolas Césard publié aux éditions Plume de Carotte-Terre vivante et "Flower power" de Beta Nowak paru aux éditions Textuel. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

En cada evento donde se anuncien juegos nuevos generalmente tenemos anuncios de juegos de series viejas que estuvieron mucho tiempo en silencio, pero después de tantos años sin una presencia en el público nos preguntamos:¿Realmente hay un espacio e interés del público o son una excusa para exprimir dinero al poco fan que queda?En las secciones tenemos:Beta QuestSerie: Touring after the ApocalypseDatos Curiosos: La llegada de la papa a la comida occidentalRandom: Vuelo a Japón, tips y anécdotasPreguntas del público: Game AwardsMuchas gracias por escuchar el episodio!!

Charles and Alex play Soulja Boy's new Rap Fighter flash game. Plus, Drake's "Nokia" was inspired by Cocomelon and Crazy Frog. Fortune Kit on Patreon: https://www.patreon.com/fortunekit Ending song: https://www.youtube.com/watch?v=Txr__rDjZ-Q

Los programas de Chiclana & Friends que hacemos de lunes a jueves a las 18:00h en Twitch.tv/Chiclanafriends ahora también en Youtube. 

Are you thinking about having a baby or trying to conceive and want to get your body and home ready first? In this episode of Start Living Sustainable, wellness coach Coach Cynthia shares simple pre-pregnancy health tips and low-toxic lifestyle shifts to reduce toxins, support your mood and hormones, and create a healthier home for pregnancy, postpartum, and your future Gen Beta baby.

Recently, both Marvel Tokon and Avatar: The Last Airbender had their beta weekends. In a shocking turn - the perception of each game FLIPPED. Where players expected Tokon to dominate attention, and Avatar to be a fun but forgettable curio tie-in game; we instead watched people lose their minds at just how good Avatar was while also being underwhelmed by Tokon. Nothing is set in stone and Tokon is by no means bad, but I don't think anyone was expecting how good Avatar has turned out to be.

ChairProfessor Yoshikatsu EtoAdvanced Clinical Research Center, Southern Tohoku Research Center for Neuroscience, Tokyo, JapanSpeakersDr Nicole Muschol International Center for Lysosomal Disorders (ICLD), University Medical Center, Hamburg-Eppendorf, GermanyProfessor Patrício AguiarInborn Errors of Metabolism Reference Center, Unidade Local de Saúde de Santa Maria / Faculty of Medicine, Lisbon University, PortugalDr Robert HopkinCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USAProfessor Yoshikatsu EtoWelcome to the Chiesi symposium. The title of this symposium, Catching the Clues, Changing the Cause of Lysosomal Storage Disease: Illuminating Complex Pathway of Rare Disease with Fabry Disease, Alpha-Mannosidosis, in Focus.This is a disclaimer: Following discussion does not focus on or depict any specific products manufactured by any pharmaceutical company. Patient cases are for medical discussion only and reflect the faculty own experience. They represent a typical clinical scenario. This presentation in part and whole may not be reproduced and not copy and not recording.I'm Dr. Eto from Tokyo, Japan, and the three distinguished speakers: Dr. Nicole Muschol from Germany, Eppendorf University. Professor Aguiar, the Portuguese, The Inborn Errors of Metabolism Reference Center, and also Professor Robert Hopkin, Cincinnati Children's Hospital, United States.The purpose of this symposium: Explore the patient journey across the LSD continuum, focusing on the unmet needs and diagnosis, and treatment initiation, and long-term management, and utilize case-based discussion focused on Alpha-mannosidosis, Fabry disease to highlight disease-specific challenges. Access where challenge persist in patient journey, and where tailored intervention can improve outcomes.Introduction of LSD patient journey with a spotlight on Fabry disease, Alpha-mannosidosis. Challenge to the diagnosis and then treatment and monitoring. Common LSD challenges over the patient journey, as shown here, and at least more than 70 different lysosomal diseases known. Incidence is about 1:5,000-1:8,000 in newborn. In the literature, much higher incidence.Multi-organ manifestation in many organ involved, and clinical heterogeneity are very complicated. The new screen method has been established already. Identify patient presymptomatically. That important by the newborn screening, something like that, early treatment essential. After the diagnosis treatment start, early and the presymptomatic treatment initiation, and usually delayed diagnosis, delayed treatment. Perceived burden of treatment may delay treatment start in patient milder form. Milder form is very difficult in the many cases, and particularly for Fabry disease also.After the treatment start and then monitoring, as you know, we discussed about the monitoring rely on the combination of clinical assessment, laboratory test, biomarkers, and imaging, and several other factors. Biomarkers and ADA drug assay lack standardization. Actually, the Alpha, and Beta, or [inaudible 00:03:19] Fabry disease, different ADA-titled measurement. Also, the patient experience between clinical visit, ERT infusion is under-reported.We discuss today two topics, two disease. Alpha-mannosidosis is very rare. In Japan, only few cases, and caused by the deficiency of Alpha-mannosidase, an accumulation of mannose-rich oligosaccharides and inheritance of autosomal-recessive. Age of onset is a very early period and younger period, adult period. Incidence approximately is very rare, 1:500,000.There are diseases we don't know exactly. If you have a treatment, maybe your incidence is much increased, and severe or attenuated [inaudible 00:04:09]. Alpha-mannosidosis is still a new disorder, and must differentiate from Mucopolysaccharidosis.On the other hand, the Fabry disease I think is very common. There are many discussion already in the past 20 years. Deficiency of a-Gal A, accumulation of Gb3⁵­­ or Lyso-Gb3, many other glycoprotein, which a terminal of a-Gal A, and X-chromosome. This is very important X-chromosomal inheritance. In case of this, and usually, female does not affect, but in case of Fabry, more of female also involved.First symptom, imagine at any age. Then incidence about 1:40,000-1:60,000. But depending on the country, as you know, classical form, about 1:40,000. Recently, after the newborn screening, late onset, very high incidence. About 90% of it—actually, we carried out a newborn screening in Japan—90% are late onset. But the clinical variety, so many clinical varieties, so incidents here, 1:3,000-1:4,000, something like that. Now, using the Alpha-mannosidosis and Fabry disease as an illustrative example, we will explore these disorders.

N520 - EASD 2025 - Novas Estratégias para preservar células beta no Diabetes Tipo 1 - Fernando Valente e Melanie Rodacki by SBD

You have a to-do list a mile long. Blogging and business tasks scattered across notebooks and apps and sticky notes. And every time you sit down to work on your blog and business, you feel paralyzed because everything feels equally important.In this episode of the Boss Lady Bloggers Podcast, I'm giving you the actual framework I use to decide what matters every single week when I work on my blogging business. This isn't a teaser. This is the real thing. By the end, you'll know exactly how to identify the three tasks that move your blog & business forward and how to protect them from everything competing for your attention.What You'll Learn in This EpisodeWhy your brain can only truly focus on three priorities (and what happens when you ignore this)The one question that instantly separates income-generating tasks from busy workHow to tell the difference between urgent and actually importantThe three filters for choosing your weekly prioritiesWhy leverage should determine what gets your attentionThe exact process I use every Sunday to plan my weekHow to protect your priorities from distractions and false urgencyThe Three Priority Framework QuestionsWhat three tasks would move me closest to my next income goal?What would happen if I didn't complete this task this week?Does this task create leverage that will keep paying off over time?Resources Mentioned[The Productive Blogger Method Beta, $47]Ready for the Full System?The Three Priority Framework is just the beginning. Inside The Productive Blogger Method, you get everything else you need to build an execution rhythm that actually sticks.The weekly planning process. The daily structure. The templates and dashboards. The mindset work. The persistence strategies.Beta pricing is $47 and founding members help shape what this becomes.[Join the Beta Program Now]

N439 - ADA 2025 - Banting lecture: célula beta, beta-amiloide e diabetes - Rodrigo Lamounier, Fernando Valente e Marcello Bertoluci by SBD

Full Video: https://open.spotify.com/episode/6DmyE1TZrx68fRM1YWSZI1?si=_6WDIljDS1q1fAKfYQZW2gLinktree: ⁠⁠https://linktr.ee/Analytic⁠⁠Join The Normandy For Additional Bonus Audio And Visual Content For All Things Nme+! Join Here: ⁠⁠https://ow.ly/msoH50WCu0K⁠⁠Analytic Dreamz plays Marvel Tokon Fighting Souls for the first time in this Notorious Mass Effect segment. Witness one of the few real-time love creations as his initial hatred transforms into deep appreciation for the 2D tag-team fighting game developed by Arc System Works and published by PlayStation Studios.Dive into the closed beta action on PlayStation 5, featuring an expanded roster of eight playable characters including new additions Spider-Man and Ghost Rider alongside Captain America, Iron Man, Storm, Doctor Doom, Ms. Marvel, and Star-Lord. Test your skills across fresh stages like X-Mansion and Savage Land, with rollback netcode enabling smooth online lobbies, versus CPU modes, spectator functionality, and uninterrupted 72-hour access from December 5-7, 2025.Originally debuted at EVO 2025 with early builds, Marvel Tokon Fighting Souls builds hype for its 2026 launch on PS5 and PC, prioritizing competitive FGC play with intuitive mechanics, balance updates from prior tests, and Marvel characters reimagined for tag-team battles.Join Analytic Dreamz for authentic reactions to Marvel Tokon Fighting Souls closed beta gameplay, roster breakdowns, stage details, and why this fighter is turning skeptics into fans. Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsPrivacy & Opt-Out: https://redcircle.com/privacy

We talk about the new Virtua Fighter documentary, the state of 2XKO, and Marvel Tokon Beta 2.

Episode #1113: Pivoting from Burnout – Alpha Energy, Culture Wars, and Media Makeovers In this raw, three-hour motivational Monday edition, host Clay Edwards lays it all bare: after years of battling cancel culture and spotlighting Jackson's systemic chaos, he's burnt out on endless politics and culture war fatigue. Drawing from a gritty documentary on the city's violence-glorifying underbelly, Clay announces a bold pivot—no more dissecting "culture rot" or chasing unsalvageable fixes. "You can't fix stupid," he declares, opting out to focus on self-improvement, red-pill truths, and uplifting men instead. Shaming works on thin-skinned politicians, but not on a "rotten and broken" cycle that's beyond redemption. The show heats up with a fiery takedown of conservative media's "beta male" hijacking: Why has the space been overrun by low-T, feminine-energy pundits who couldn't "fight their way out of a wet paper bag"? Clay ranks top figures like Ben Shapiro (super cuck), Tucker Carlson (alpha), and Joe Rogan (definite alpha), calling for more high-testosterone leaders to reclaim the fight. Guest co-host Andrew Allgasser joins for hour three, diving into fatherlessness epidemics, the military as a manhood forge (especially for at-risk demographics), and how softened institutions like wrestling and Boy Scouts signal a broader assault on masculinity.   Midway, caller Angela (aka MIC Magazine) vents on political disingenuousness, blind loyalty in voting blocs, and the exhaustion of endless cycles—echoing Clay's wit's-end vibe. Sports fans get a nod: Hype for Ole Miss's playoff clash with Tulane (fingers crossed for Georgia next) and Mississippi State's Duke's Mayo Bowl berth on January 2nd, plus live watch party plans at McB's. Wrapping with cultural curveballs, Clay rallies against Netflix's Warner Bros. bid (root for Paramount's hostile takeover to shield icons like Batman from woke twists) and slams the Somali funding scandal in Minnesota—millions funneled to Al-Shabaab terrorists, exposing ignored infiltration. It's unfiltered evolution: From Jackson's soul-sucking grind to forging stronger men and mocking the left's absurd antics (think Antifa's '80s aerobics protest). Strap in—Clay's flipping the script for a fiercer, no-sugar-added reality check.  

✨ A Rhythm for Slowing DownMindfulness, sound healing, and ritual — woven into every frequency. This is a sensory journey curated by interdisciplinary artist and creative calm strategist Sya Warfield.Calm isn't something you wait for. It's something you create.Ritual Era Meditation is a 12-week digital experience designed to restore your nervous system, soften your edges, and bring clarity to your inner world. Each week, you'll explore sound frequencies, gentle practices, and grounding rituals — all from the comfort of your own rhythm.Your soft place to return to, anytime:https://studio.com/apps/sya/calm

The whole crew has been thoroughly enjoying Cosmic Invasion, but have some itty bitty nitpicks. We follow that up with Marvel Tokon Beta and have a second serving of Tag Talk and Assist Advice. Community questions round out the long show. It's a fun one!

What happens when educational leadership is grounded in the wisdom of community, driven by emotion as much as intellect, and unflinchingly committed to equity? This week on Voices for Excellence, Dr. Michael Conner sits down with Dr. Brenda Garcia Castro—assistant principal at Century Community Charter School in Inglewood, California, and adjunct professor at Pepperdine University—for a deeply human and intellectually rigorous conversation that bridges systemic transformation with personal journey.A proud bilingual leader, researcher, immigrant mother, and rising scholar with both an EdD and a PhD in progress, Dr. Garcia Castro offers a visionary blueprint for what it means to lead from love, data, and intentionality all at once. Her groundbreaking conceptual model, the Optimal Partnership for Thriving Integration, reframes how schools engage immigrant families—not as passive recipients of services but as empowered, trusted, and essential collaborators in education.Together, she and Dr. Conner explore how schools can evolve their culture—not just structurally but emotionally—to build durable ecosystems of access, trust, and healing for students and their families. At the center of this journey: authenticity, radical listening, and a commitment to meeting families exactly where they are, while preparing all students, especially Generation Alpha and Beta, for an unknown but exciting future shaped by AI and workforce transformation.What you'll learn from this episode: Bold leadership means leaning into discomfort to serve a greater purpose.  Support for families is system design—not an afterthought.  Immigrant families want access, growth, and connection—so how are we listening? Trust and relationships are the real curriculum of school leadership.  Culture isn't declared—it's co-constructed through presence and modeling. AI + workforce prep begins by demystifying tech and amplifying student voice. Dr. Brenda Garcia Castro reminds us: the future of equitable education is personal, purposeful, and possible—when we meet it with heart and rigor. This episode is a stirring reminder that education systems can, and must, be designed for all to thrive. It's time to redefine success not just by test scores, but by the depth of belonging, access, and opportunity each child experiences.Subscribe and share to continue driving the future of education for all.

Sun, 07 Dec 2025 16:00:00 GMT http://relay.fm/mpu/826 http://relay.fm/mpu/826 2025 State of the Platforms (Part 2) 826 David Sparks and Stephen Hackett The guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. The guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. clean 8679 Subtitle: iPhone, Apple TV, iCloud, Other Services, and the EcosystemThe guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. This episode of Mac Power Users is sponsored by: Squarespace: Save 10% off your first purchase of a website or domain using code MPU. Indeed: Join more than 3.5 million businesses worldwide using Indeed to hire great talent fast. DEVONthink: Get Organized — Unleash Your Creativity. Get 10% off. Links and Show Notes: Sign up for the MPU email newsletter and join the MPU forums. More Power Users: Ad-free episodes with regular bonus segments Submit Feedback Give the Gift of RelayAll annual plans are 20% off through the end of the year! Mac Power Users #824: Life After iPadOS 26 - Relay Mac Power Users #825: 2025 State of the Platforms (Part 1) - Relay iPhone Heir to the Throne - 512 Pixels iPhone Air review: Back to the future – Six Colors Report: iPhone Air 2 is delayed until 2027 so Apple can add a second camera to it - 9to5Mac iPhone 17 Pro review: Orange you glad you've gone Pro? – Six Colors Mac Power Users #822: iPhone 17 Photography with Tyler Stalman - Relay Apple responds to iPhone 17 Pro scratch and durability concerns - 9to5Mac Set up eSIM on iPhone - Apple Support Use eSIM while traveling internationally with your iPhone - Apple Support Use the Camera Control on iPhone - Apple Support Use and customize the Action button on iPhone - Apple Support What's new in iOS 26 - Apple Support ‎Widgetsmith - App Store Here's everything new for the Phone app in iOS 26 - 9to5Mac CarPlay's Messages App for iOS 26 is Bad - 512 Pixels So, Three Things - 512 Pixels Apple Intelligence - Apple John Giannandrea to retire from Apple - Apple Apple's New Siri Will Be Powered By Google Gemini - MacRumors iOS 26.1 Beta 4 Adds Liquid Glass Transparency Toggle - 512 Pixels iOS 26.2 Lock Screen Gets Liquid Glass Slider - MacRumors Apple University - Wikipedia The iPhone Ultra - 512 Pixels TV & Home - Apple Apple TV+ to Apple TV Rebrand Now Official, Here's the New Intro - MacRumors No Ad Tier for Apple TV 'At This Time,' According to Eddy Cue - MacRumors The Original Apple TV - Quinn Nelson on YouTube iCloud+ - Apple iCloud Plans - Apple Entertainment - Services - Apple Apple One - Apple The future of Apple Fitness+ is 'under review' amid reorganization: report - 9to5Mac Apple introduces AppleCare One, streamlining coverage into a single plan - Apple Android Quick Share can now work with iOS's AirDrop - Google

Full Video: https://open.spotify.com/episode/3eWFBc8yxkBixifTRIEP9R?si=_JzzRlTjShSTGJXid9tb8ALinktree: ⁠https://linktr.ee/Analytic⁠Join The Normandy For Additional Bonus Audio And Visual Content For All Things Nme+! Join Here: ⁠https://ow.ly/msoH50WCu0K⁠Analytic Dreamz plays Marvel Tokon Fighting Souls for the first time in this Notorious Mass Effect segment. Witness one of the few real-time love creations as his initial hatred transforms into deep appreciation for the 2D tag-team fighting game developed by Arc System Works and published by PlayStation Studios.Dive into the closed beta action on PlayStation 5, featuring an expanded roster of eight playable characters including new additions Spider-Man and Ghost Rider alongside Captain America, Iron Man, Storm, Doctor Doom, Ms. Marvel, and Star-Lord. Test your skills across fresh stages like X-Mansion and Savage Land, with rollback netcode enabling smooth online lobbies, versus CPU modes, spectator functionality, and uninterrupted 72-hour access from December 5-7, 2025.Originally debuted at EVO 2025 with early builds, Marvel Tokon Fighting Souls builds hype for its 2026 launch on PS5 and PC, prioritizing competitive FGC play with intuitive mechanics, balance updates from prior tests, and Marvel characters reimagined for tag-team battles.Join Analytic Dreamz for authentic reactions to Marvel Tokon Fighting Souls closed beta gameplay, roster breakdowns, stage details, and why this fighter is turning skeptics into fans. Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsPrivacy & Opt-Out: https://redcircle.com/privacy

Sun, 07 Dec 2025 16:00:00 GMT http://relay.fm/mpu/826 http://relay.fm/mpu/826 David Sparks and Stephen Hackett The guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. The guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. clean 8679 Subtitle: iPhone, Apple TV, iCloud, Other Services, and the EcosystemThe guys wrap up their review of Apple's 2025 with a look at the iPhone, Apple TV, iCloud, and Apple's other services. They then zoom out and look at the overall ecosystem. This episode of Mac Power Users is sponsored by: Squarespace: Save 10% off your first purchase of a website or domain using code MPU. Indeed: Join more than 3.5 million businesses worldwide using Indeed to hire great talent fast. DEVONthink: Get Organized — Unleash Your Creativity. Get 10% off. Links and Show Notes: Sign up for the MPU email newsletter and join the MPU forums. More Power Users: Ad-free episodes with regular bonus segments Submit Feedback Give the Gift of RelayAll annual plans are 20% off through the end of the year! Mac Power Users #824: Life After iPadOS 26 - Relay Mac Power Users #825: 2025 State of the Platforms (Part 1) - Relay iPhone Heir to the Throne - 512 Pixels iPhone Air review: Back to the future – Six Colors Report: iPhone Air 2 is delayed until 2027 so Apple can add a second camera to it - 9to5Mac iPhone 17 Pro review: Orange you glad you've gone Pro? – Six Colors Mac Power Users #822: iPhone 17 Photography with Tyler Stalman - Relay Apple responds to iPhone 17 Pro scratch and durability concerns - 9to5Mac Set up eSIM on iPhone - Apple Support Use eSIM while traveling internationally with your iPhone - Apple Support Use the Camera Control on iPhone - Apple Support Use and customize the Action button on iPhone - Apple Support What's new in iOS 26 - Apple Support ‎Widgetsmith - App Store Here's everything new for the Phone app in iOS 26 - 9to5Mac CarPlay's Messages App for iOS 26 is Bad - 512 Pixels So, Three Things - 512 Pixels Apple Intelligence - Apple John Giannandrea to retire from Apple - Apple Apple's New Siri Will Be Powered By Google Gemini - MacRumors iOS 26.1 Beta 4 Adds Liquid Glass Transparency Toggle - 512 Pixels iOS 26.2 Lock Screen Gets Liquid Glass Slider - MacRumors Apple University - Wikipedia The iPhone Ultra - 512 Pixels TV & Home - Apple Apple TV+ to Apple TV Rebrand Now Official, Here's the New Intro - MacRumors No Ad Tier for Apple TV 'At This Time,' According to Eddy Cue - MacRumors The Original Apple TV - Quinn Nelson on YouTube iCloud+ - Apple iCloud Plans - Apple Entertainment - Services - Apple Apple One - Apple The future of Apple Fitness+ is 'under review' amid reorganization: report - 9to5Mac Apple introduces AppleCare One, streamlining coverage into a single plan - Apple Android Quick Share can now work with iOS's AirDrop - Google

Send us a textDay 6 of the 12 Days of Podsmas dives straight into culture, trends, and the big shift we're seeing in 2025. I talk about the Beta Generation — the young kids setting the tone for what's cool again. From fashion to music to how they use technology, they're swinging the pendulum in a whole new direction… and honestly, it's refreshing.We get into the whole idea of dumb phones making a comeback — why kids and even adults are choosing simplicity over constant notifications, and what that means for the future of culture and mental health.I also break down what's hot on the 2025 Christmas list, the gadgets, toys, sneakers, and trends people are going crazy for this year. And of course, a lot more thoughts on where the culture is heading and how fast everything moves.A fun, reflective, trend-heavy episode for the Podsmas season.

Send us a textDay 6 of the 12 Days of Podsmas dives straight into culture, trends, and the big shift we're seeing in 2025. I talk about the Beta Generation — the young kids setting the tone for what's cool again. From fashion to music to how they use technology, they're swinging the pendulum in a whole new direction… and honestly, it's refreshing.We get into the whole idea of dumb phones making a comeback — why kids and even adults are choosing simplicity over constant notifications, and what that means for the future of culture and mental health.I also break down what's hot on the 2025 Christmas list, the gadgets, toys, sneakers, and trends people are going crazy for this year. And of course, a lot more thoughts on where the culture is heading and how fast everything moves.A fun, reflective, trend-heavy episode for the Podsmas season.

You've bought the blogging courses. You've watched the trainings. You've downloaded the PDFs and bookmarked the strategies and told yourself that this time, this next thing, would finally be the answer.It wasn't. And you're starting to wonder if anything ever will be.In this episode of the Boss Lady Bloggers podcast, I'm validating your skepticism while showing you why The Productive Blogger Method isn't what you think it is. This isn't a course. It's something different. And that distinction might be exactly what finally gets you unstuck.What You'll Learn in This EpisodeWhy your resistance to buying another course is actually wisdom, not weaknessThe real reason courses haven't worked for you (and why it's not your fault)The difference between a course and an execution systemWhy information was never your problem in the first placeHow the 50/20/15/10/5 framework exposes what most bloggers get backwardsWhat it actually looks like to prioritize execution over educationWhy I priced The Productive Blogger Method at $47Resources MentionedThe Productive Blogger Method Beta, $47Boss Lady BloggersReady to Stop Learning and Start Doing?The Productive Blogger Method isn't another course to add to your collection. It's an execution system that helps you implement what you already know.No more modules to climb through. No more content to consume. Just a framework, a rhythm, and a dashboard that tells you exactly what to do when you sit down at your laptop.Beta pricing is $47. Founding members are already inside building their execution rhythms.[Click here to join the beta]

Esta semana proponemos que los juegos de acción en mundo abierto deberían voltear más a ver mecánicas de sobrevivencia para incorporar a sus juegos y sentir mucho más la inmersión de explorarlos y utilizar los recursos que resguardan ¿es momento de agregar stats de hambre, sueño, higiene, salud como modificadores al personaje o podría abrumar demasiado a los jugadores?En las secciones acostumbradas tenemos:Beta Quest en grupoEl Kick-Ass Super SentaiDatos Curiosos de papelería¿La muerte del cine como lo conocemos?La opción alterna del Apple WatchPreguntas del públicoBonusMuchas gracias por escucharnos! Pasen una excelente semana

Kyle Clark, CEO of BETA Technologies (BETA), explains how the company accelerated its momentum in the electric aerospace and VTOL markets. On recent earnings, Kyle notes the company's more than $3 billion backlog and the ways BETA aims to secure profits on its contract. He also explains why electric aviation is "significantly less expensive" from traditional methods. ======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Want to know an A+ Setup? An Alpha Pick that's a STRONG BUY (meaning great fundamentals) with technicals saying the dip is an over reaction. RINSE AND REPEAT. CYBER MONDAY SALES END SOON: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TRENDSPIDER SALE - GET SIDEKICK ⁠⁠⁠⁠⁠⁠SEEKING ALPHA BUNDLE - ALPHA PICKS AND PREMIUM Save over $200⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Seeking Alpha Premium - FREE 7 day trial ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Alpha Picks - Save $100 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Seeking Alpha Pro - for the Pros ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠EPISODE SUMMARY

The latest In Touch With iOS with Dave he is joined by Jill McKinley, Chuck Joiner, Jeff Gamet, Eric Bolden, Marty Jencius. Episode 398 covers Apple's 2025 App Award winners, the Podcast of the Year, new updates for iOS/iPadOS/visionOS 26.2 RC, and a redesigned native ExpressVPN Mac app. The panel reviews major AI news—including Claude 4.5, ChatGPT's shopping feature, and the possibility of ads—while debating the privacy concerns around ChatGPT integrating with Apple Health. Other highlights include Apple's foldable iPhone patent, Apple Music Replay, accessibility features, and a big week for Apple Arcade with Subway Surfers+. A funny, insightful, wide-ranging episode with lots of community engagement and tech analysis. The show notes are at InTouchwithiOS.com  Direct Link to Audio  Links to our Show Give us a review on Apple Podcasts! CLICK HERE we would really appreciate it! Click this link Buy me a Coffee to support the show we would really appreciate it. intouchwithios.com/coffee  Another way to support the show is to become a Patreon member patreon.com/intouchwithios Website: In Touch With iOS YouTube Channel In Touch with iOS Magazine on Flipboard Facebook Page BlueSky Mastodon X Instagram Threads Summary In this episode of In Touch With iOS, Dave and an all-star panel—Jill McKinley, Marty Jencius, Jeff Gamet, Chuck Joiner, Eric Bolden, and Guy Serle—jump into a packed week of Apple news, updates, AI breakthroughs, and plenty of humor. The show opens with a discussion about the frigid weather sweeping across the country, before moving into Apple's newly announced App Award Winners. The panel covers winners across iPhone, iPad, Mac, Apple TV, and Vision Pro—including the iPhone App of the Year Timbo and Vision Pro winner Explore POV—with commentary on design choices, spatial computing innovation, and whether they personally use the selected apps. Next, the 2025 Apple Podcast of the Year—The Rest Is History—leads the group into a conversation about podcast quality, history storytelling, and the growing depth of Apple's podcast ecosystem. Updates to visionOS 26.2 RC are discussed, including expanded Travel Mode for buses and cars, support for spatial accessories (like Logitech's stylus), and improvements to Freeform. Eric even admits the new features were compelling enough for him to install the beta. Updates for iOS/iPadOS 26.2 RC also make news, adding the Liquid Glass lock screen slider, Reminders alarms, new AirPods Live Translation support in the EU, and Podcasts app refinements. Jeff warns listeners to hold off on macOS Tahoe due to persistent audio issues, reinforcing that stability still matters more than flash. The show then pivots into a major AI segment featuring:     •    Anthropic's Claude Opus 4.5, touted as the new coding champion among AI tools     •    ChatGPT's new holiday shopping assistant, which impressed some panelists     •    The controversial discovery of ads in ChatGPT's app code, sparking fears of "enshittification"     •    A possible Apple Health integration, which launches a passionate privacy debate     •    Real-world examples of AI massively reducing work time—from spreadsheets to meeting analytics The group revisits Apple's newest patent describing a crease-free foldable iPhone using liquid metal, prompting speculation on durability, user experience, and whether Apple can create a foldable without the hallmark crease. Apple's Year-End Music Charts and Apple Music Replay lead to panelists sharing their most-played artists—ranging from Supertramp to Rush to 80s icons—and poking fun at Dave's unavoidable Taylor Swift top rankings. Apple also releases a beautifully produced Accessibility in College ad, highlighting assistive technologies like magnifier, voiceover, and live captions. The panel praises Apple's leadership in accessible design and speculates on future features for glasses-based products. Finally, the team dives into a major Apple Arcade update, featuring five new games including Subway Surfers+, SpongeBob Patty Pursuit 2, PowerWash Simulator, and more. The topic unexpectedly evolves into a discussion of how simulation games—like power washing or trucking—can offer therapeutic calm for many players. Topics and Links Breaking News Apple Announces 2025 App Store Award Winners, Including iPhone App of the Year  Apple Announces 2025 Podcast of the Year  In Touch With Vision Pro this week.  visionOS 26.2 RC is released this week visionOS 26.2 RC Release Notes visionOS Notes This update expands Travel Mode to cars and busses, adds support for hand-drawn content with spatial accessories, and includes other features, bug fixes, and security updates for your Apple Vision Pro. • Travel Mode lets passengers use Apple Vision Pro on cars and busses in addition to airplanes and trains • Support for hand-drawn content with spatial accessories like Logitech Muse in Notes, Freeform, and any PencilKit-enabled app • Tables in Freeform can hold text, images, documents, and drawings, with cells that intelligently resize to fit, bringing structure to the content to your board. Beta this week iOS 26.2 Release Candidate dropped this week.  Apple Seeds iOS 26.2 and iPadOS 26.2 Release Candidates to Developers and Public Beta Testers iPadOS 26.2 RC and more now available ahead of coming launch Apple Seeds watchOS 26.2, tvOS 26.2 and visionOS 26.2 Release Candidates watchOS 26.2 has four changes for Apple Watch, here's everything new Apple Seeds Second tvOS 26.2 Release Candidate iOS 26.2 release date: Here's when new iPhone features are coming In Touch With Mac this week macOS Tahoe 26.2 Release Candidate Now Available to Developers and Public Beta Testers ExpressVPN gets a native Mac app, optimized connectivity on iOS In Touch with AI this week.  Anthropic Launches Claude Opus 4.5 With Improved Coding and Agent Capabilities ChatGPT Adds AI Shopping Research Feature for Holiday Gift Finding ChatGPT is Going to Start Showing You Ads Apple Health Integration Seemingly Coming to ChatGPT Dave's experience using CoPilot creating a spreadsheet list of Dell Monitors for work  Other Topics Marty gives his thoughts on a patent. Apple's Crease-Free Foldable iPhone may also use Liquid Metal in the Hinges Use as reference only: What to Expect From Apple This December: iOS 26.3 Beta, Replay 2025, and More Apple Music Shares 2025 Year-End Charts Apple Music Replay 2025 Now Fully Available Apple Books Launches 2025 Year in Review Experience Apple Pushes iPhone Users Still on iOS 18 to Upgrade to iOS 26  Other news: Crucial is shutting down — because Micron wants to sell its RAM and SSDs to AI companies instead News iPhone Car Keys Support Coming to More Audi Vehicles Apple Releases Firmware Update for iPhone Air MagSafe Battery iPhone 17 Demand Is Breaking Apple's Sales Records Apple Shares New 'I'm Not Remarkable' Ad  Apple Arcade Just Got the Most Downloaded Mobile Game Ever and More Announcements Macstock 9 has wrapped for 2025. Attendees will receive a link for the session recordings when  they're ready in 30-45 days. If you missed Macstock we missed you! Why not purchase a digital pass to relive all the amazing presentations? Click the link below to purchase the digital pass. Macstock X has already been announced July 10,11,12, 2026 hopeful you all can join us.  Macstock IX Digital Pass Our Host Dave Ginsburg is an IT professional supporting Mac, iOS and Windows users and shares his wealth of knowledge of iPhone, iPad, Apple Watch, Apple TV and related technologies. Visit the YouTube channel https://youtube.com/intouchwithios follow him on Mastodon @daveg65, , BlueSky @daveg65  and the show @intouchwithios   Our Regular Contributors Jeff Gamet is a podcaster, technology blogger, artist, and author. Previously, he was The Mac Observer's managing editor, and Smile's TextExpander Evangelist. You can find him on Mastadon @jgamet Pixelfed @jgamet@pixelfed.social and Bluesky @jgamet.bsky.social‬ Podcasts The Context Machine Podcast  Retro Rewatch Retro Rewatch His YouTube channel https://youtube.com/jgamet Marty Jencius, Ph.D., is a professor of counselor education at Kent State University, where he researches, writes, and trains about using technology in teaching and mental health practice. His podcasts include Vision Pro Files, The Tech Savvy Professor and Circular Firing Squad Podcast. Find him at jencius@mastodon.social  https://thepodtalk.net  Eric Bolden is into macOS, plants, sci-fi, food, and is a rural internet supporter. You can connect with him by email at eabolden@mac.com, on Mastodon at @eabolden@techhub.social, on his blog, Trending At Work, and as co-host on The Vision ProFiles podcast.   Jill McKinley works in enterprise software, server administration, and IT A lifelong tech enthusiast, she started her career with Windows but is now an avid Apple fan. Beyond technology, she shares her insights on nature, faith, and personal growth through her podcasts—Buzz Blossom & Squeak, Start with Small Steps, and The Bible in Small Steps. Watch her content on YouTube at @startwithsmallsteps and follow her on X @schmern. Find all her work at http://jillfromthenorthwoods.com  Chuck Joiner is the host of MacVoices and hosts video podcasts with influential members of the Apple community. Make sure to visit macvoices.com and subscribe to his podcast. You can follow him on Twitter @chuckjoiner and join his MacVoices Facebook group. Guy Serle is one of the hosts of the new The Gmen Show along with GazMaz and email GMenshow@icloud.com  @MacParrot and @VertShark on X  Vertshark on YouTube, Google Voice +1 Area code  703-828-4677

I hope you are having a wonderful week. I’m having a great week because I got Todd and James to join me on this episode which features not only the longest small talk segment of all time but also the shortest answer to a question of all time. Truly, a record breaking show. So, buckle up for the Homebrew Happy Hour podcast!… THE home brew #podcast where we answer all of your home brewing questions and discuss anything related to craft beer! A NOT SO SUBTLE REMINDER: If you appreciate the things we do here at Homebrew Happy Hour, consider joining our Trub Club! — https://www.patreon.com/bePatron?u=21132635 On Today’s Show: Ideal Hose for CMB Flow Control, Full Keg with a Leaky Post, Mashing in the Beta Range, & Best Line Connections for a Draft Beer System 00:00:00 – 00:025:41 Sponsors & Small Talk00:25:42 – 00:31:22 Flow Control Hose00:31:23 – 00:33:23 Leaky Post on a Full Keg00:33:24 – 00:40:33 Beta Mashing00:40:34 – 00:54:48 Draft System Line Connections Links for this episode:Kegconnection Fizz Kits: https://www.kegconnection.com/fizz-kits-carbonating-kits.htmlFlow Control Event Faucet: https://www.kegconnection.com/fa320-kc-cmb-flow-control-event-or-party-faucet.htmlHomebrew Kegs: https://www.kegconnection.com/kegs.htmlFLOTit 2.0 Floating Diptube: https://www.kegconnection.com/kp200-flotit-20-stainless-steel-floating-dip-tube-no-beer-left-behind.html We want to hear from you! If you have a question that you'd like us to discuss on a future episode, please click on the “Submit a Question” link at the top of our website or you can now call in your questions via our questions hotline @ 325-305-6107 and leave your message after the beep. Let us know what you think and enjoy the show! cheers, joshua ———————– https://www.kegconnection.com/ Each and every episode is made possible by Kegconnection.com! Build the kegerator or keezer of your dreams using Kegconnection.com’s unique customizable product options that allows you to get exactly what you need. Kegconnection.com also stocks products and solutions for kegging kits, draft systems, hardware, components, cleaning and much much more. Kegconnection.com has been operating for more than 18 years in the industry and has established expertise and superior customer service. ————————– Thank you to our show's sponsor, Imperial Yeast, for supporting us and the homebrewing community. Learn more about why we LOVE Imperial Yeast by checking out their entire line, available at https://www.imperialyeast.com/ ————————– Thank you to our show's sponsor, Hops Direct! Family owned and operated, Hops Direct provides a wide variety of hop selection and ships directly to your door. Learn more by visiting https://hopsdirect.com/?utm_source=HHH&utm_medium=link&utm_campaign=HHH+link ————————– This episode is brought to you by, Muntons Malts – a company that is passionate about providing premium malts to brewers worldwide. YOU can experience the difference Muntons offers by joining a recipe receiving tier of our Trub Club because every kit that ships out now includes premium Muntons Malt, join at https://www.patreon.com/HomebrewHappyHour ————————– Become a Patron! Reminder that these episodes are ultimately made possible because of YOUR support. Consider becoming a member of our TRUB CLUB via our Patreon page and receive perks such as merch, exclusive group access and content, recipes, and some tiers even get monthly recipe kits mailed to you! https://www.patreon.com/HomebrewHappyHour #homebrewing #homebrewers #craftbeer #beer #brewing #craftbrew #kolsch #webcast #show

In this episode of Inside Personal Growth, Greg sits down with David Homan — classical composer, nonprofit leader, global “connector of connectors,” and author of the bestselling book Orchestrating Connection. David shares the remarkable life events that shaped his philosophy on building authentic relationships at scale, from childhood adversity to leading an arts organization through crisis, to eventually forming a global community of over 2,300 super connectors. He breaks down the five principles of meaningful connection, explains why vulnerability and accountability matter more than ever, and reveals how to design relationships intentionally instead of leaving them to chance. David also shares powerful real-life stories that show how generosity and trust can create life-changing ripple effects. This episode is an inspiring guide to the art and science of human connection — and how it can transform your career, relationships, and purpose. ⭐ What Listeners Will Learn 1. The difference between networking and intentionally designing relationships 2. The Five Principles of Connection 3. Why reputation is the strongest currency you have 4. How to shift from “What can I get?” to “How can I serve?” 5. The emotional story that shows the true power of connection 6. How David built a global community of trusted connectors 7. The truth about finding your tribe 8. Practical steps listeners can use immediately Our Guest, David Homan: ➥ Book: Orchestrating Connection: How to Build Purposeful Community in a Tribal World ➥ Buy Now: https://a.co/d/1Iq1hGh ➥ https://orchestratedconnecting.com/ Beta sign-up for SOAR Connect: available on the website ➥soarconnect.ai ➡️LinkedIn: https://www.linkedin.com/in/davidrhoman Learn more about your Inside Personal Growth host, Greg Voisen: ➥ https://gregvoisen.com ➡️Instagram: https://www.instagram.com/insidepersonalgrowth/ ➡️Facebook: https://www.facebook.com/InsidePersonalGrowth/ ➡️LinkedIn: https://www.linkedin.com/in/gregvoisen/ ➡️Twitter/ X: https://twitter.com/lvoisen/

Join The Struggle's Patreon community to get 100+ hours of Bonus Episodes, Pro Clinics, Uncut Videos, and Submit Questions for Future Guests. FREE TRIAL available!  https://www.patreon.com/thestruggleclimbingshow - In this episode, pro climber Ethan Pringle explores: Dealing with discomfort Releasing mental baggage Struggling with self-image Prioritizing outdoor climbing over indoor training  What he and Sharma have in common Going back for unfinished business  Goals for Meltdown and La Rambla The benefit of discovering “tired beta” What the best boulderers do   There's always better beta. Always.  A sport climber's mentality for bouldering  Managing risk and fear on scary boulders - BIG THANKS TO THE AMAZING SPONSORS OF THE STRUGGLE WHO LOVE ROCK CLIMBING AS MUCH AS YOU DO: PhysiVantage: the official climbing-nutrition sponsor of The Struggle. Use code STRUGGLE15 at checkout for 15% off your full-priced nutrition order. ForceBoard: A better way to train fingers. Portable, accurate, and created to train finger strength and endurance exactly how YOU need it. Score $10 off and support the show by using code STRUGGLE10 at checkout. Rúngne: Soft threads and high performing chalk! Use Code STRUGGLE for 10% Off Bags, Buckets, Chalk & Apparel from Rúngne! Rungne.com Nature Climbing: Beautifully crafted lifting edges and hangboards that feature real granite edges for improved texture and skin conditioning. Sustainably crafted works of art, I love them so much! Get 20% off everything at natureclimbing.com using code STRUGGLE.  And check out ALL the show's awesome sponsors and exclusive deals at thestruggleclimbingshow.com/deals   - Shoutout to Matt Waltereese for being a Victory Whip supporter on Patreon! So mega. - Here are some AI generated show notes (hopefully the robots got it right) 00:00 Introduction 01:26 Ethan Pringle's Climbing Achievements 02:49 Deep Dive into Climbing Philosophy 04:25 Interview Begins: Ethan's Background and Struggles 12:03 Mindset and Emotional Challenges in Climbing 56:09 Unlocking Beta: The Key to Climbing Success 57:42 The Philosophy of Constant Refinement 01:00:23 Creative Solutions and Beta Breakthroughs 01:03:37 The Importance of Strategy and Tactics 01:19:11 Managing Fear and Mental Barriers in Climbing - Follow along on Instagram @thestruggleclimbingshow and YouTube /@thestruggleclimbingshow - The Struggle is carbon-neutral in partnership with The Honnold Foundation, whose mission is to promote solar energy for a more equitable world. - This show is produced and hosted by Ryan Devlin, and edited by Glen Walker. The Struggle is a proud member of the Plug Tone Audio Collective, a diverse group of the best, most impactful podcasts in the outdoor industry. - The struggle makes us stronger! I hope your training and climbing are going great.  - And now here are some buzzwords to help the almighty algorithm get this show in front of people who love to climb: rock climbing, rock climber, climbing, climber, bouldering, sport climbing, gym climbing, how to rock climb, donuts are amazing. Okay, whew, that's done. But hey, if you're a human that's actually reading this, and if you love this show (and love to climb) would you think about sharing this episode with a climber friend of yours? And shout it out on your socials? I'll send you a sticker for doing it. Just shoot me a message on IG – thanks so much! 

Beta-glucans might be one of the most overlooked levers in immune resilience, and that has major implications for longevity. Talking with my long-time friends and colleagues Drs. Bob Rountree and Chris D'Adamo reminded me just how powerful this molecule truly is. The clinical reach here is stunning, from immune aging and cancer support to vaccine response, gut–brain effects, and overall resilience. What struck me most is how beta-glucans help the innate immune system respond more effectively over time, from overtraining and chronic infections to vaccine responsiveness. Clinicians really need this on their radar. I think you're going to find this conversation eye-opening. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Bob Rountree, MD, is a leading figure in integrative and functional medicine with more than 40 years of clinical experience. Medical Director of Boulder Wellcare and long-time IFM faculty, he is widely published and a respected educator in personalized medicine, botanical therapies, and immune health. Chris D'Adamo, PhD, is a research scientist and epidemiologist focused on how nutrition, lifestyle, and environmental factors influence health. An Assistant Professor at the University of Maryland School of Medicine, he has led numerous clinical studies, published widely, and is a trusted advisor and educator in integrative and lifestyle medicine. THANKS TO OUR SPONSOR BetterWay Health (Consumers) BWHLabs (Practitioners) WEBSITE: http://bwhlabs.com/kara EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Book a practitioner call and receive a complimentary bottle of beta-glucan to try personally or with a patient at http://bwhlabs.com/kara CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Today, I'm joined by Ana Montero and André Marques-Smith, co-founders of Atlas. A behind-the-ear brain sensing wearable, Atlas tracks clarity, stress, and cognitive performance in real time, bringing neuroscience research from academia to consumers' hands. In this episode, we discuss building the brain health wearable for everyday life. We also cover: Atlas's five-year R&D process Modernizing outdated mental health diagnostics Early detection and prevention of neurological conditions Subscribe to the podcast → insider.fitt.co/podcast   Subscribe to our newsletter → insider.fitt.co/subscribe   Follow us on LinkedIn → linkedin.com/company/fittinsider    Join the Waitlist: www.atlaswearable.com  Atlas on LinkedIn: https://www.linkedin.com/company/atlaswearable/  Atlas on X (Twitter): https://x.com/atlaswearable  - The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart fitness ecosystem for fitness and health facilities. Fitt Talent: https://talent.fitt.co/  Consulting: https://consulting.fitt.co/  Investments: https://capital.fitt.co/   Chapters:  (00:00) Introduction  (01:30) Ana and André's backgrounds in neuroscience  (03:25) The problem with mental health diagnostics today  (04:30) Why existing wearables can't track brain activity  (05:50) Building sensors that work in motion conditions  (06:25) Five years of R&D  (08:00) Why behind-the-ear brain sensing  (10:30) What Atlas measures (13:00) Brain scores vs. peripheral body metrics  (15:30) Use cases (18:00) The personalization challenge in brain data  (20:30) Long-term vision (23:00) Building consumer traction before clinical applications  (25:30) Fundraising and investor interest in brain tech  (28:00) Beta testing program and user feedback  (30:20) Research studies: stress, nutrition, and brain activity  (32:35) Early detection and prevention  (35:05) Conclusion

Andrew Wang sees the Fed's December meeting next week as one of the final market catalysts of the year, urging investors to stay on their toes after rate cut chances spiked in the last couple week. Bitcoin's price action is another factor he believes will serve as a critical signal for high beta appetite. When it comes to stocks he likes, Andrew sees Apple (AAPL) holding strength amid A.I. shakiness, and Costco (COST) as a bastion of retail companies. ======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about

In this episode of The Profit Cleaners Podcast, Brandon Schoen and Brandon Condrey introduce BunnyBid, the first official app in the new CleanStack suite. Built from eight years of real operational data, proven pricing formulas, and the original Profit Cleaners matrix, BunnyBid is designed to help cleaning business owners generate fast, accurate, and profitable quotes — every single time.The episode walks through how BunnyBid streamlines the entire quoting process: from configuring market wages and cleaner pay, to instantly calculating job times, margins, and profitability. The Brandons explain how the tool replaces spreadsheets, eliminates guesswork, ensures consistency across all quotes, and helps users follow up faster — all crucial components of winning more jobs in today's competitive market.You will also learn about upcoming integrations with leading CRMs, built-in AI tools for generating quote descriptions, and additional features that help businesses track winning price points and optimize performance over time. They also reveal the broader CleanStack AI roadmap and preview ShineProof, the next app designed to automate before-and-after social content.This episode provides a detailed look at how BunnyBid can immediately upgrade your quoting workflow, enhance professionalism, improve accuracy, and support sustainable growth for cleaning businesses at any stage.Listen now!

Supermoon (12/4) Clarity Boost.✨ A Rhythm for Slowing DownMindfulness, sound healing, and ritual — woven into every frequency. This is a sensory journey curated by interdisciplinary artist and creative calm strategist Sya Warfield.Calm isn't something you wait for. It's something you create.Ritual Era Meditation is a 12-week digital experience designed to restore your nervous system, soften your edges, and bring clarity to your inner world. Each week, you'll explore sound frequencies, gentle practices, and grounding rituals — all from the comfort of your own rhythm.Your soft place to return to, anytime:https://studio.com/apps/sya/calm

Pavan Davuluri only spoke at one Ignite 2025 session, and it did not deserve the hate he got. But what did he really say? Copilot is a front-end for apps and cloud AI services, agents are background processes. Apps in Windows need to become programmatic so AI and agents can control them. You are in control. You being IT and the user. These experiences are off by default, opt-in, and optional. This is the end of whatever BS argument anyone has about this stuff. Copilot Voice because AI is better when you babble and is often more natural than typing Key concept: Apps, CLIs, etc. expect exact commands, AI is all about intent, just do what I want, not exactly what I say. This is why, yes, people WILL want to talk to their PCs (and other devices) UIs for these new features will look/feel natural in Windows Search box in Taskbar is getting updated to orchestrate between local/web search and Copilot capabilities, including agents Agents will appear as app icons in Taskbar when fired, can be check in on, can post notifications for you to attend to Integration of M365 Copilot capabilities with Windows - Better together story, with things like Writing Assistance for every text box Accessibility updates thanks to AI - Fluid Dictation, which is what makes Copilot Voice make so much sense All the security, privacy, and IT management the audience expects Windows Insider Program Dev and Beta builds include Full Screen Experience on all PCs, new Notepad app, more Hardware - Earnings Lenovo PC business up 12 percent to $15.1 billion, 25.6 percent unit share HP up 4 percent to $14.6 billion, but job cuts for AI are coming Dell PC business up 3 percent to $1.41 billion AI and Stuff Microsoft releases local Fara-7B agentic model for computer use ChatGPT's new coding model is optimized for Windows Dear God, you must see Nano Banana Pro to understand Google's lead Google is bringing AirDrop to Android, starting with Pixel. This is what happens when regulators "force design changes on OS makers." Xbox and Gaming Xbox Cloud Gaming usage is up 45 percent YOY. Sure. What's 45 percent of 3 people? Xbox Cloud Gaming is adding per-game resolution settings, to 1440p for Game Pass Ultimate customers ROG Xbox Ally is getting default game profiles, in preview for 40 titles now Microsoft open sources the source code for Zork, Zork II, and Zork III New Chromebook buyers get one year of Nvidia GeForce NOW with Fast Pass Tips and Picks Tip of the week: Finding experts is more important than ever We live in the age of stupid. Find the smart and never let go Also, Xbox is having a good Black Friday sale Also: Perplexity Comet on Android RunAs Radio this week: Christmas Gifts for SysAdmins with Joey Snow and Rick Claus https://runasradio.com/Shows/Show/1012 Brown liquor pick of the week: Sidetrack Stone Whisky https://www.huskdistillers.com/shop/sidetrack-stone-whisky These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/960 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: outsystems.com/twit cachefly.com/twit

Pavan Davuluri only spoke at one Ignite 2025 session, and it did not deserve the hate he got. But what did he really say? Copilot is a front-end for apps and cloud AI services, agents are background processes. Apps in Windows need to become programmatic so AI and agents can control them. You are in control. You being IT and the user. These experiences are off by default, opt-in, and optional. This is the end of whatever BS argument anyone has about this stuff. Copilot Voice because AI is better when you babble and is often more natural than typing Key concept: Apps, CLIs, etc. expect exact commands, AI is all about intent, just do what I want, not exactly what I say. This is why, yes, people WILL want to talk to their PCs (and other devices) UIs for these new features will look/feel natural in Windows Search box in Taskbar is getting updated to orchestrate between local/web search and Copilot capabilities, including agents Agents will appear as app icons in Taskbar when fired, can be check in on, can post notifications for you to attend to Integration of M365 Copilot capabilities with Windows - Better together story, with things like Writing Assistance for every text box Accessibility updates thanks to AI - Fluid Dictation, which is what makes Copilot Voice make so much sense All the security, privacy, and IT management the audience expects Windows Insider Program Dev and Beta builds include Full Screen Experience on all PCs, new Notepad app, more Hardware - Earnings Lenovo PC business up 12 percent to $15.1 billion, 25.6 percent unit share HP up 4 percent to $14.6 billion, but job cuts for AI are coming Dell PC business up 3 percent to $1.41 billion AI and Stuff Microsoft releases local Fara-7B agentic model for computer use ChatGPT's new coding model is optimized for Windows Dear God, you must see Nano Banana Pro to understand Google's lead Google is bringing AirDrop to Android, starting with Pixel. This is what happens when regulators "force design changes on OS makers." Xbox and Gaming Xbox Cloud Gaming usage is up 45 percent YOY. Sure. What's 45 percent of 3 people? Xbox Cloud Gaming is adding per-game resolution settings, to 1440p for Game Pass Ultimate customers ROG Xbox Ally is getting default game profiles, in preview for 40 titles now Microsoft open sources the source code for Zork, Zork II, and Zork III New Chromebook buyers get one year of Nvidia GeForce NOW with Fast Pass Tips and Picks Tip of the week: Finding experts is more important than ever We live in the age of stupid. Find the smart and never let go Also, Xbox is having a good Black Friday sale App pick of the week: Copilot Mode in Microsoft Edge Also: Perplexity Comet on Android RunAs Radio this week: Christmas Gifts for SysAdmins with Joey Snow and Rick Claus https://runasradio.com/Shows/Show/1012 Brown liquor pick of the week: Sidetrack Stone Whisky https://www.huskdistillers.com/shop/sidetrack-stone-whisky These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/960 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: outsystems.com/twit cachefly.com/twit

In this episode, Dr. Jockers and Dr. Chris D'Adamo break down how your immune system learns, adapts, and strengthens over time—and why beta-glucan is one of the most researched natural compounds for resilience. You'll hear how immune modulation, not just stimulation, can keep you healthy through stress, seasonal shifts, and everyday exposures.   You'll learn how gut health, stress hormones, and immune function are deeply connected, and why improving your stress tolerance starts with lowering inflammation and supporting your microbiome. Dr. D'Adamo explains the science behind cortisol, trained immunity, and the role beta-glucan plays in balancing your system long before symptoms appear.   You'll also discover why immune aging may be one of the biggest drivers of biological aging—and how supporting your innate defenses can influence longevity, energy, and mood. Throughout the conversation, you'll pick up practical strategies you can start using today to strengthen immunity in a real, sustainable way.   In This Episode:  00:00 Introduction to Beta-Glucan and Cancer Research 00:37 Training Your Immune System 01:23 Beta-Glucan: Sources and Benefits 05:48 Interview with Dr. Chris D'Adamo: Immune System Focus 08:07 Beta-Glucan and Immune Modulation 09:44 Cold and Flu Season: Immune System Tips 11:24 Beta-Glucan and Biological Aging 17:45 Beta-Glucan Dosage and Usage 20:23 Personal Immune System Strategies 22:55 Trained Immunity and Beta-Glucan 25:14 Beta-Glucan and Cortisol Reduction 30:05 The Role of Beta-Glucan in Detoxification 33:07 Supplements and Modern Toxicity 34:45 Beta-Glucan for Kids 36:26 Exciting Research on Immune Health 39:17 Daily Habits for a Strong Immune System 42:12 The Benefits of Sauna and Cold Exposure 47:10 Choosing the Right Beta-Glucan Supplement 48:28 Conclusion and Final Thoughts Hydration is one of the fastest ways to boost your energy, sharpen your focus, curb cravings, and even improve the look and feel of your skin — but water alone isn't enough. Your cells need electrolytes to actually absorb and use that hydration. Paleovalley Essential Electrolytes delivers premium, full-spectrum minerals with zero sugar, no artificial ingredients, and unprocessed sea salt, helping you feel more energized, clear-headed, and vibrant — and look more radiant from the inside out. Just one scoop a day can make a noticeable difference. Try Paleovalley Essential Electrolytes and save 15% by visiting Paleovalley.com/jockers and using code JOCKERS at checkout.   If you're serious about reducing your toxic load, I highly recommend upgrading to the P600 ceramic cookware. It's 100% free from Teflon, PFAS, and plastic coatings, ensuring a non-toxic cooking experience. Right now, you can get it for 50% off, plus an extra 20% off with the code SAFE20 at checkout! Don't miss this limited-time offer—head to chefsfoundry.com/jockers to claim your discount today!     "Beta-glucans aren't just immune boosters—they're immune modulators, helping balance and strengthen your body's defenses against pathogens."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Get 15% off Paleovalley Electrolites: paleovalley.com/jockers – Use code JOCKERS Use code SAFE20 at chefsfoundry.com/jockers to claim your discount today!     Connect with Dr. Chris D'Adamo: Website - https://www.betterwayhealth.com/   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/