Podcasts about Gaba

Huberman Lab Podcast Notes “Nicotine is not the cause of cancer; nicotine is not the carcinogen. It's the other things in tobacco or associated with the nicotine delivering device that are causing cancer and the other negative impacts on our health.” – Dr. Andrew HubermanThe state nicotine puts your body in is almost the optimal state for getting mental work done: you feel alert, focused, and able to concentrate – but at the same time, your body feels relaxed (this is the behavioral side of why it's addictive)Nicotine has 4 major effects of nicotine on the brain and neural circuits: (1) triggers the release of dopamine and increases levels; (2) increases attention, focus, and concentration (via an increase in acetylcholine); (3) increases alertness and arousal (net effect of an increase in epinephrine & norepinephrine); (4) appetite suppressionThere is some evidence nicotine gum (not smoking, vaping, dipping, snuffing – those are never good) may increase cognitive performanceAll methods of ingesting nicotine are not the same: vaping is the most dangerous and most addictive because of the speed and concentration at which it hits the bloodstream and the rapidness at which dopamine spikes (until you need more and more)Why is it so hard to quit? The first week you stop, your dopamine is lower than baseline because you're not giving your body & brain the hit it's come to expect at a certain time so you feel much worse (remember the dopamine pleasure-pain balance)Withdrawal sets in about 4 hours after the last smoke or vape – people wake up in nicotine withdrawal and immediately need nicotineTip to quit smoking: change the method of cessation each week to intermittently reward the dopamine system without expectation – start with the patch, then gum, then nasal sprayRead the full notes @ podcastnotes.orgIn this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine's ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://www.roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Nicotine (00:02:47) Momentous Supplements (00:03:41) Tool: Brief Daily Meditation & Focus (00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements (00:10:43) Thesis, InsideTracker, ROKA (00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine (00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors (00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA (00:30:58) AG1 (Athletic Greens) (00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting” (00:37:29) Nicotine, Norepinephrine & Alertness/Energy (00:41:10) Nicotine & Effects on Appetite & Metabolism (00:46:47) Nicotine & Effects on Body: Sympathetic Tone (00:51:29) Nicotine & Cognitive Work vs. Physical Performance (00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency (00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells (01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health (01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal (01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression (01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri (01:30:16) Bupropion (Wellbutrin) & Quitting Smoking (01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum (01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy (01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook Title Card Photo Credit: Mike Blabac Disclaimer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.22.509020v1?rss=1 Authors: Granat, L., Ranson, D., Hamer, E., Chakrabarty, R. P., Mattedi, F., Fort-Aznar, L., Hirth, F., Sweeney, S., Vagnoni, A., Chandel, N. S., Bateman, J. M. Abstract: Mutations in mitochondrial complex I cause mitochondrial complex I deficiency, a group of severe neurological diseases that can result in death in infancy. The mechanisms underlying complex I deficiency pathogenesis remain poorly understood, and as a result there are currently no available treatments. To better understand the causes of neuronal dysfunction in complex I deficiency, we modelled complex I deficiency in Drosophila by knocking down the mitochondrial complex I subunit ND-75 (NDUFS1) specifically in neurons. Neuronal complex I deficiency causes locomotor defects, seizures and reduced lifespan. At the cellular level, complex I deficiency leads to mitochondrial morphology defects, reduced endoplasmic reticulum-mitochondria contacts and activation of the endoplasmic reticulum unfolded protein response (UPR) in neurons. Remarkably, we find that expression of the yeast non-proton translocating NADH dehydrogenase NDI1 in neurons, which couples NADH oxidation to transfer of electrons into the respiratory chain, reinstates endoplasmic reticulum-mitochondria contacts, prevents UPR activation and rescues the behavioural and lifespan phenotypes caused by complex I deficiency. Metabolomic analysis shows that NDI1 expression also reconfigures neuronal metabolism and implicates increased GABA levels as a contributor to the neurological manifestations of complex I deficiency. Together, these data indicate that NDI1 abrogates UPR signalling and reprogrammes metabolism to alleviate neuronal dysfunction caused by neuronal complex I deficiency. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

In this episode we talk about stress and how to recover from it.   First, we must acknowledge that being human involves exposure to stress!    Research shows that over 60% of us had an adverse childhood event and at least 70% of us have experienced a major stress loss or trauma in adulthood.    When we exist as humans in these stressful environments it starts to feel normal to be stressed.     In fact, we can become addicted to feeling stressed and so we get stuck in stress mode. Our bodies' cortisol and adrenaline levels get imbalanced, and our nervous system operates in constant stress alert.    Cortisol and adrenaline are our main stress hormones. It's not that we want zero adrenaline and it's not that we want zero cortisol. These are substances that we need a healthy amount of every day.     These hormones are unique to everyone. One person in stress mode might have high cortisol high adrenaline while another person might be low cortisol and low adrenaline.     I remember when my daughter was young, and I was running my practice and seeing patients and trying to keep up with my house and everything until it felt like I could barely breathe. Sprinting through each day barely getting enough sleep. I know many of you feel the same way, how are we supposed to catch up when we can't even keep up?     I kept doing research on stress until I figured out the protocol that addresses the different stress types for each person so I can help every patient in a specific way.    It's about figuring out what was thrown out of balance by stress, what got disrupted by stress: the cortisol levels, the adrenaline levels, GABA, iron, magnesium, etc.    Many times, patients ask me how can I be tired and anxious at the same time? It's not logical!     Sometimes our bodies are not that black and white so you could have one system that's causing you to feel over stimulated (high adrenaline) and at the same time you could feel tired (low cortisol or low iron).     Your body is trying to tell you it needs help! It is trying to tell you that there is something out of balance, so we need to look at the symptoms and look for patterns to act on them. Of course, we could temporarily fix this with caffeine or even a Xanax but you would not be acting on the root of the problem and therefore you will not be really healing.      There are ways to rebalance your body using nutrients and herbs and even exposure to nature that help us reset and help your body re-calibrate and rebalance.     Recovery activities like journaling, listening to music, doing mindfulness or meditation, spending time in nature, spending time with our pets or listening to the sounds in nature, all of this helps recalibrate our nervous system or vagus nerve and it signals calmness to our brain.    There are ways I can teach you to know your stress type and start addressing it by using nutrients, start practicing mindfulness that helps you to gain more self-love and compassion and practice connecting with others.     I have done extensive research throughout the years which has allowed me to write several books about stress, including my most recent one Master your Stress Reset Your Health.     I found stress recovery is unique to each person based on their stress type. There are different ways of implementing diet, sleep, exercise changes for each person for each stress type.     I invite you to join me in whichever format works best for you whether it's ordering the book and reading the paper back or listening to the audiobook or listening to more How Humans Heal podcasts or reading the blogs or guides available on my website, or meeting with me one-on-one or joining me in one of my group programs. I'm making my protocol available in many different forms because again we're not all the same, we're not all one size one-size-fits-all in terms of how stress affects us, nor how we best learn or apply stress recovery.     I am so glad you are here and look forward to connecting with you again soon take care. Please subscribe, share and post a review if you find this information helpful.   -   Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Books and Resources:    Order My New Book: https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576   Stress Warrior Book (FREE)  HTTPS://DOCTORDONI.COM/STRESSWARRIOR      Stress Warrior Stress Resiliency Facebook Group (FREE)  HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR     7-day Stress Reset (FREE)  HTTPS://DOCTORDONI.COM/STRESS-RESET     HPV & Cervical Dysplasia Guide (FREE)  HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/     -   Personalized Solutions:    If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH     To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine's ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://www.roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Nicotine (00:02:47) Momentous Supplements (00:03:41) Tool: Brief Daily Meditation & Focus (00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements (00:10:43) Thesis, InsideTracker, ROKA (00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine (00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors (00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA (00:30:58) AG1 (Athletic Greens) (00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting” (00:37:29) Nicotine, Norepinephrine & Alertness/Energy (00:41:10) Nicotine & Effects on Appetite & Metabolism (00:46:47) Nicotine & Effects on Body: Sympathetic Tone (00:51:29) Nicotine & Cognitive Work vs. Physical Performance (00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency (00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells (01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health (01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal (01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression (01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri (01:30:16) Bupropion (Wellbutrin) & Quitting Smoking (01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum (01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy (01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook Title Card Photo Credit: Mike Blabac Disclaimer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.508161v1?rss=1 Authors: Brown, E. B., Zhang, J., Lloyd, E., Lanzon, E., Botero, V., Tomchik, S., Keene, A. C. Abstract: Neural regulation of sleep and metabolic homeostasis are critical in many aspects of human health. Despite extensive epidemiological evidence linking sleep dysregulation with obesity, diabetes, and metabolic syndrome, little is known about the neural and molecular basis for the integration of sleep and metabolic function. The RAS GTPase-activating gene Neurofibromin (Nf1) has been implicated in the regulation of sleep and metabolic rate, raising the possibility that it serves to integrate these processes, but the effects on sleep consolidation and physiology remain poorly understood. A key hallmark of sleep depth in mammals and flies is a reduction in metabolic rate during sleep. Here, we use indirect calorimetry to define the role of Nf1 on sleep-dependent changes in metabolic rate. Flies lacking Nf1 fail to suppress metabolic rate during sleep, raising the possibility that loss of Nf1 prevents flies from integrating sleep and metabolic state. Sleep of Nf1 mutant flies is fragmented with a reduced arousal threshold in Nf1 mutants, suggesting Nf1 flies fail to enter deep sleep. The effects of Nf1 on sleep can be localized to a subset of neurons expressing the GABA receptor Rdl. Selective knockdown of Nf1 in Rdl-expressing neurons increases gut permeability and reactive oxygen species (ROS) in the gut, suggesting a critical role for deep sleep in gut homeostasis. Together, these findings suggest Nf1 acts in GABA-sensitive neurons to modulate sleep depth in Drosophila. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

このイディオムは、誰かの為に自分がお金を支払ったり、「私のおごり」と言いたい時に使われます。 “my treat”と省略しても使われます。 今回のインストラクターは、Anthonyさん！ ナビゲーターは、荒戸完（from ZIP-FM「MORNING BOOOOOOST!」）

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.14.507785v1?rss=1 Authors: Lalwani, P. S., Polk, T. A., Garrett, D. D. Abstract: Moment-to-moment neural variability has been shown to scale positively with the complexity of stimulus input. However, the mechanisms underlying the ability to align variability to input complexity are unknown. Using a combination of computational modeling, fMRI, MR spectroscopy, and pharmacological intervention, we investigated the role of aging and GABA in neural variability during visual processing. We found that participants expressed higher variability when viewing more complex stimuli. Such variability modulation was associated with higher baseline visual GABA levels and was reduced in older adults. When pharmacologically increasing GABA activity, we found that participants with lower baseline GABA levels showed higher drug-related increase in variability modulation, consistent with an inverted-U account. Finally, higher baseline GABA and variability modulation were jointly associated with better visual-discrimination performance. These results suggest that GABA plays an important role in how humans utilize neural variability to adapt to the complexity of the visual world. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

このイディオムは、一晩考えるという意味で、何かしら決断をしないといけない時に使える便利な表現です。 じっくりと考えたい時やすぐに答えがでない場合に使われることが多いです。 今回のインストラクターは、Anthonyさん！ ナビゲーターは、荒戸完（from ZIP-FM「MORNING BOOOOOOST!」）

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.10.507343v1?rss=1 Authors: Godavarthi, S. K., Hiramoto, M., Ignatyev, Y., Levin, J. B., Li, H., Pratelli, M., Borchardt, J., Czajkowski, C. M., Borodinsky, L. N., Sweeney, L., Cline, H. T., Spitzer, N. C. Abstract: Alteration of the electrical activity of the nervous system causes plasticity in neural circuits. Many of the changes occur at synapses. For example, neurotransmitter switching involves changes in the identity of presynaptic neurotransmitters and corresponding changes in postsynaptic transmitter receptors, thereby achieving a match between the transmitter and its cognate receptor. However, it is unknown whether changes in postsynaptic receptors can regulate presynaptic transmitters. Here we address this question at the developing neuromuscular junction. We find that blockade of endogenous postsynaptic acetylcholine receptors leads to loss of the cholinergic phenotype in motor neurons and the reappearance and stabilization of an earlier, developmentally transient glutamatergic phenotype. In addition, exogenous postsynaptic expression of GABAA receptors leads to the appearance and stabilization of an earlier, transient GABAergic motor neuron phenotype. Thus, acetylcholine receptors are necessary to stabilize acetylcholine as a transmitter, and GABAA receptors are sufficient to stabilize GABA as a transmitter. GARLH4 links the GABAA receptor to neuroligin, and Lrp4 links the acetylcholine receptor to dystroglycan through rapsyn and MUSK. Both neuroligin and dystroglycan bind to neurexin, which in turn binds to forms of the CASK transcription factor in motor neurons. Knock down of GARLH4 or Lrp4 postsynaptically or CASK presynaptically blocks stabilization of the GABAergic and cholinergic phenotypes. These results implicate transsynaptic bridges in establishing receptor-dependent stability of the cognate neurotransmitters. Our findings provide opportunities to investigate a role for dysfunctional transmitter receptors in neurological disorders that involve the loss of the presynaptic transmitter. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Josué tuvo que ir al encuentro de los cinco reyes que atacaron a Gabaón, pero Dios intervino y es dió una victoria contundente. --- Send in a voice message: https://anchor.fm/pastorjhonatanoficial/message Support this podcast: https://anchor.fm/pastorjhonatanoficial/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.07.506899v1?rss=1 Authors: Pasanta, D., He, J. L., Ford, T. C., Oeltzschner, G., Lythgoe, D., Puts, N. A. Abstract: Functional magnetic resonance spectroscopy (fMRS) can be used to investigate neurometabolic responses to external stimuli in-vivo, but findings to date are inconsistent. We performed a systematic review and meta-analysis on 49 human fMRS studies that measured levels of the primary neurotransmitters Glutamate (Glu), Glx (Glutamate + Glutamine), and GABA. Data were extracted, grouped by metabolite, stimulus domain, and brain region, and then analysed by determining standardised effect sizes. The quality of individual studies (such as the choice of acquisition parameters and reporting quality) was rated with a standardised check list. When results were analysed by metabolite type across all studies, small to moderate effect sizes of 0.29-0.47 (p less than 0.05) were observed for changes in Glu and Glx regardless of stimulus domain and brain region, but no significant effects were observed for GABA. Further analysis suggests that Glu, Glx and GABA responses differ by stimulus domain or task and vary depending on the time course of stimulation and data acquisition technique. In summary, we establish effect sizes and directionality of GABA, Glu and Glx response in all currently available fMRS studies. This work provides normative ground to improve consensus and reproducibility of fMRS research and highlights the importance of standardised reporting and minimal best practice. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Today we are talking about Selank and its potential benefits. All this and more in less than 2 minutes.  What is Selank? Selank is a lab-made peptide that was made by combining the naturally occurring peptide tuftsin with another sequence to make it more stable. Tuftsin makes up a large part of the natural antibody IgG. This antibody in our blood helps prevent infections.  What are the BENEFITS?  You may hear Selank referred to as the “anti-anxiety” peptide or a “nootropic.” In clinical trials, it has been shown to provide an anti-anxiety effect. It does this by affecting GABA. GABA is an inhibitory neurotransmitter. It slows down your brain by blocking signals in your central nervous system. It produces a calming effect and can reduce stress, improve sleep, and relieve anxiety. Selank works by enhancing the effect of GABA, thus reducing anxiety. While most traditional anxiety prescription medications can cause bothersome side effects, clinical studies have shown that Selank doesn't. You should not experience side effects like drowsiness, dependence, or withdrawal symptoms.  In addition to its anti-anxiety benefits, Selank stabilizes blood enkephalins. Enkephalins are natural peptides found in the brain that help with stress.  Its nootropic actions improve cognitive function, attention, memory, and motivation. Selank increases the amount of brain-derived neurotrophic factor (BDNF), an important brain growth compound in the hippocampus that helps with learning and memory. Other studies have shown Selank to increase levels of IL-6, an inflammatory protein in the body that helps fight off infections. It's also shown to decrease blood sugar and prevention of weight gain. This could be very helpful for those with metabolic syndrome.  How do I take Selank? Selank is given as an intranasal (into the nose) spray daily. You should not use more than you're prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Selank. Possible side effects include headaches. Also, since it's a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience.  You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide therapy information together in one easy place. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week! Pro Tips Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container. We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

EPISODIO COMPLETO EN www.patreon.com/profesorbriceno SPOTIFY https://open.spotify.com/show/3rFE3ZP8OXMLUEN448Ne5i?si=1cec891caf6c4e03 APPLE PODCASTS https://podcasts.apple.com/es/podcast/que-se-vayan-todos/id676871115 GOOGLE PODCASTS https://www.ivoox.com/en/podcast-que-se-vayan-todos_sq_f11549_1.html FEED PARA CUALQUIER APP DE PODCASTS https://www.ivoox.com/feed_fg_f11549_filtro_1.xml FECHAS DE PRESENTACIONES www.profesorbriceno.com/tour Invitamos al hombre que se quitó 50 kilos, a Ingrid, a Gaba y Rey y llegamos a la conclusión de que el mejor cuerpo es .... SOLO PARA SUSCRIPTORES. PROHIBIDA SU REPRODUCCIÓN. HUMOR NEGRO NO APTO PARA MENORES NI ESPIRITUS SENSIBLES.

Intr0beatz - Duh Duh Duh (Original Mix) Bondax, Never Dull - Fade (feat. Shells) (Never Dull Extended Remix) Mistura feat. Jemini - Want Me Back Louie Vega, Leroy Burgess, The Universal Robot Band, Patrick Adams - Barely Breaking Even (Louie Vega Boogie Mix) Kerri Chandler, Bluey Robinson - Tenacity [Output] (Main Vocal Mix) Yooks, Nevada Cato - Let's Do It! (Original Mix) N'dinga Gaba, DJ Spen, Marc Evans - Until You (N' Dinga Gaba And DJ Spen's Decadance Remix) Mark Picchiotti, The Absolute, Suzanne Palmer, Craig J. Snider, DJ Spen, Michele Chiavarini - I Believe (DJ Spen & Michele Chiavarini's Extended Remix) Soulista, Tracy Hamlin - Backfired (2022 Vocal) Micky More & Andy Tee, Cevin Fisher - All About The Culture (Extended Mix) Dames Brown, Andrés, Amp Fiddler, Folamour - What Would You Do? (Folamour 12" Remix) Joey Negro, Linda Clifford - Won't Let Go Feat. Linda Clifford (Joey Negro Club Mix) Platinum City, Brian Lucas, Suki Soul - Can You Dig It? (Extended Mix) Doug Willis, Dave Lee - Doug's Disco Theme Bobby & Steve, Johnnie Fiori, Dr Packer - You Will Survive - Dr Packer Remixes (Main Mix) Praise Cats feat. Andrea Love - Shined On Me (Les Bisous Remix) Fabio Pierucci, Birdee - Holding Me Back (Birdee Remix) Solution, Odyssey Inc., Victor Simonelli - Feels So Right (Odyssey Inc. Remix) Static Revenger - Happy People [Original 12" Mix] Sebb Junior - Dolla Bill

このイディオムは、聞き手のために話を簡潔にまとめて手短に話す、という意味で、 “long story short”と省略しても使われます。 今回のインストラクターは、Anthonyさん！ ナビゲーターは、荒戸完（from ZIP-FM「MORNING BOOOOOOST!」）

Josué recibió la visita de un pueblo extranjero. Los de Gabaón o los gabaonitas fueron a hacer alianza con Josué. Ellos habían escuchado de las hazañas que había hecho Josué y prefirieron hacer alianza con él, aunque para lograrlo, tendrían que engañarlo. Y asi lo hicieron! El problema estaba que Josue, no le consultó a Dios y esta alianza le salió muy costosa. --- Send in a voice message: https://anchor.fm/pastorjhonatanoficial/message Support this podcast: https://anchor.fm/pastorjhonatanoficial/support

================================================== ==SUSCRIBETEhttps://www.youtube.com/channel/UCNpffyr-7_zP1x1lS89ByaQ?sub_confirmation=1================================================== == DEVOCIÓN MATUTINA PARA ADOLESCENTES 2022“UN SALTO EN EL TIEMPO”Narrado por: DORIANY SÁNCHEZDesde: PERÚUna cortesía de DR'Ministries y Canaan Seventh-Day Adventist Church  03 DE SEPTIEMBREDE VUELTA AL FUTURO «Entonces Josué habló a Jehová [...] y dijo: [...]: "Sol, detente en Gabaón, y tú, luna, en el Valle de Ajalón". [...] El sol se paró en medio del cielo, y no se apresuró a ponerse casi un día entero» (Josué 10: 12, 13, RV95).En 1752, Inglaterra cambió un cambio de calendario que adelantó el calendario diez días. ¿Cómo suena eso? Bueno, ¡la gente se acostó el 3 de septiembre y se despertó el 14 de septiembre! Fue para ajustar los diez días que ya había ganado el calendario. Verás, un año tiene en realidad 365 días y un cuarto. Cuando han pasado varios años, hay que añadir días enteros al calendario. Actualmente, cada cuatro años, un día extra en febrero se encarga de resolver el problema. pero en la Inglaterra de aquella época aún no se había dado con esa solución.Si se ganara un cuarto de día más cada año, y nunca se tuviera un año bisiesto, al cabo de cuarenta años se tendría que adelantar diez días al calendario. Y de ahí el cambio de calendario: un salto hacia adelante en el futuro, y perder diez días. ¿Te lo imaginas? La mayoría de nosotros no pensamos en lo que ese tipo de cambio supondría para nuestra vida cotidiana. Quizá no cambie mucho las cosas para los estudiantes, pero para los adultos sería desastroso. Los niños perderían diez días del año escolar, y eso podría estar bien, pero los adultos (y algunos adolescentes) perderían diez días de trabajo, mientras que los bancos seguirían queriendo cobrarles la cuota mensual de la hipoteca y los gastos de las tarjetas de crédito. Sería como un gran cambio de horario de verano, salvo que adelantaríamos nuestros calendarios, en lugar de nuestros relojes. Los calendarios de nuestras computadoras también tendrían que ser reajustados.Hay una historia en la Biblia que habla de un cambio de hora. Sucedió en los días de Israel, cuando acababan de entrar en la Tierra Prometida. Josué y el ejército estaban luchando en una batalla, pero la batalla aún no había terminado, y la luz del día estaba pasando rápidamente. «Entonces Josué habló a Jehová [...] y dijo [...]: "Sol, detente en Gabaón, y tú, luna, en el Valle de Ajalón". [...] El sol se paró en medio del cielo, y no se apresuró a ponerse casi un día entero». ¿No es increíble? Josué le pidió a Dios que detuviera el sol en su lugar, y Dios le concedió el favor. Las tribus de Israel siguieron luchando durante otras veinticuatro horas, y ganaron la batalla.¡Qué historia tan maravillosa! Nunca hubo un día igual, porque el Señor escuchó la oración de un hombre.

Josué 10: ¡Saca a esos reyes y no los dejes entrar!Josué 10:7-19:Josué subió de Gilgal con toda la gente de guerra y todos los hombres valientes, y el SEÑOR dijo a Josué: —No tengas temor de ellos, porque yo los he entregado en tu mano. Ninguno de ellos podrá resistir delante de ti.Después de subir toda la noche desde Gilgal, Josué cayó sobre ellos de repente. El SEÑOR los turbó delante de Israel y los hirió con gran mortandad en Gabaón. Los persiguió por el camino que sube a Bet-jorón y los hirió hasta Azeca y Maqueda. Y sucedió que cuando iban huyendo de los israelitas por la bajada de Bet-jorón, el SEÑOR arrojó desde el cielo grandes piedras sobre ellos, hasta Azeca; y murieron. Fueron muchos más los que murieron a causa de las piedras del granizo, que aquellos a quienes los hijos de Israel mataron a espada.Entonces Josué habló al SEÑOR el día en que el SEÑOR entregó a los amorreos ante los hijos de Israel, y dijo en presencia de los israelitas: “¡Sol, detente sobre Gabaón; y tú, luna, sobre el valle de Ajalón!”. Y el sol se detuvo y la luna se paró, hasta que el pueblo se hubo vengado de sus enemigos. ¿No está escrito esto en el libro de Jaser? El sol se detuvo en medio del cielo, y no se apresuró a ponerse casi un día entero. Nunca hubo un día semejante ni antes ni después de aquel día, cuando el SEÑOR escuchó la voz de un hombre; porque el SEÑOR combatía por Israel. Luego Josué, y todo Israel con él, volvió al campamento en Gilgal.Los cinco reyes huyeron y se escondieron en la cueva de Maqueda. Y le fue dicho a Josué que los cinco reyes habían sido hallados escondidos en la cueva de Maqueda. Entonces Josué dijo: —Hagan rodar grandes piedras a la entrada de la cueva y pongan hombres junto a ella, para que los guarden. Pero ustedes, no se detengan, sino persigan a sus enemigos y hiéranles la retaguardia. No los dejen entrar en sus ciudades, porque el SEÑOR su Dios los ha entregado en su mano.------------------------------------------------Este es uno de los eventos bíblicos más sorprendentes que se encuentran en la Biblia. El Señor ve que cinco reyes se juntaron para pelear contra Gabaón por haber hecho pacto con Israel, y ellos llamaron a Josué para que los defendiera. Josué sale al encuentro de estos reyes amorreos y los ataca porque ¡el Señor le confirmó que se los daría en sus manos!La batalla fue tan larga que ya estaba anocheciendo y Josué sabía que en la noche ellos podían huir. Era vital la luz del día para poderlos vencer y que no se escaparan los reyes.En ese momento, Josué hizo una oración que nadie había hecho. Pidió que el sol y la luna se detuvieran, y ¡Dios hizo el milagro de extenderle la luz del día para que pudieran detener a sus enemigos! Humanamente es imposible, pero ¡para Dios no hay nada imposible!Quiero que miremos la estrategia de guerra de Josué. Él les dijo que no dejaran entrar a los reyes a sus ciudades porque el Señor se los entregó en sus manos. Ese es un momento crucial para la victoria, pues un rey destronado y lejos de la protección de la ciudad es un rey derrotado! Igualmente, debemos descubrir la causa de un problema y atacar de raíz. Cuando descubres alguna clase de mal que esté haciendo daño a tu familia, en ese momento debes identificarlo y no dejarlo regresar. Nuestro Señor Jesús enseñó este principio espiritual en Marcos 3:27: “Ninguno puede entrar en la casa de un hombre fuerte y saquear sus bienes, si antes no le ata, y entonces podrá saquear su casa.”¡Debemos atar al hombre fuerte! Si es un sentimiento de odio que cada vez que lo recuerdas se convierte en un tropiezo, hay que desecharlo. Una enemistad con alguien debemos resolverla. Pregúntate qué clase de rey es el que está dominando el territorio que debes conquistar, identificalo y no lo dejes volver a entrar! Envidia, enemistad, brujería, ira, lujuria, etc., cualquier cosa que sea un tropiezo para el desarrollo de un hogar saludable, en paz y armonía. ¡Tú puedes hacerlo en el nombre de Jesucristo! Dios te revelará el rey que hay que destronar, hazlo con valor y de forma decisiva no lo dejes volver a entrar. Soy Eduardo Rodríguez. Que el Señor te dé la victoria sobre el hombre fuerte.

Josué 9: El peligro de no consultar a Dios. Veamos un episodio doloroso cuando los Israelitas fueron engañados por el pueblo cananeo.Josué 9:11‭-‬19 RVA2015:Por eso nuestros ancianos y todos los habitantes de nuestra tierra nos hablaron diciendo: “Tomen en sus manos provisión para el camino, vayan al encuentro de ellos y díganles: ‘Nosotros somos sus siervos; por tanto, hagan alianza con nosotros'. Este pan nuestro estaba caliente cuando tomamos provisiones de nuestras casas para el camino, el día que salimos para venir a ustedes. He aquí que ahora ya está seco y mohoso. También estos odres estaban nuevos cuando los llenamos. He aquí que ahora ya están rotos. Y esta ropa nuestra y nuestras sandalias están ya viejas a causa del camino tan largo. Los hombres de Israel tomaron de sus provisiones, pero no consultaron al SEÑOR. Entonces Josué hizo paz con ellos, e hizo una alianza con ellos de conservarles la vida. Los jefes de la congregación también se lo juraron. Y sucedió que tres días después de haber hecho alianza con ellos, se enteraron de que eran sus vecinos y que habitaban en medio de ellos. Entonces los hijos de Israel partieron, y al tercer día llegaron a las ciudades de ellos. Sus ciudades eran Gabaón, Cafira, Beerot y Quiriat-jearim. Pero los hijos de Israel no los mataron, porque los jefes de la congregación les habían jurado por el SEÑOR Dios de Israel. Por eso toda la congregación murmuraba contra los jefes. Y todos los jefes respondieron a toda la congregación: —Nosotros les hemos jurado por el SEÑOR Dios de Israel. Por eso ahora no los podemos tocar.—-----------------------------------------------Aquí vemos una gran lección dolorosa que tuvieron que aprender los israelitas. ¡Es la lección de consultar a Dios todo!Los gabaonitas encontraron la forma para engañarles, haciéndose pasar por un pueblo muy lejano queriendo establecer tratos de paz con ellos.Si Josué y los jefes de Israel hubieran primero consultado al Señor como venían haciéndolo en todo su caminar, no hubieran caído en la trampa del engaño.Cuando leemos esto, podemos ver que fue una "novatada" que cometieron ellos; por haber actuado apresuradamente y que tal vez se dejaron llevar por la emoción al escuchar esas palabras lisonjeras que hablaban muy lindo del Dios de Israel y las obras majestuosas, o por verlos con compasión por la forma lastimera con que se presentaron, o por el placer de hacer tratados de paz con otras naciones lejanas.Sea cual sea la razón, ninguna justificaba que ellos hubieran caído en la trampa y pusieran en riesgo a todo el pueblo y al plan divino de Dios. Los gabaonitas se convirtieron de enemigos a protegidos. Al final, convivieron entre los israelitas haciendo trabajos menos atractivos como el cargar agua y leña para el templo de Dios. Más adelante veremos cómo esto no le agradó a Dios y el gran problema que esto les trajo. Pero hoy quiero que reflexionemos en lo peligroso que es el no consultar al Señor nuestras acciones y decisiones. Cuando estamos bajo emociones fuertes podemos lamentar cualquier palabra que digamos o acción que hagamos. Sea la compra de algo que nos va a traer mucho tiempo pagarlo a crédito, un viaje sin preparación, divorciarse, o casarse sin conocer bien a la persona, etc.Pidamos a Dios y pongamos mucho en práctica el don de la prudencia.Aunque todo problema tenga su solución y Dios nos ayude a salir de situaciones difíciles, las consecuencias siempre estarán ahí como cicatrices que nos recuerdan ese momento en el que desobedecimos y nos golpeamos fuertemente, dejando heridas lamentables.Es inevitable cometer errores, pero sí podemos evitar muchos dolores de cabeza al tomar un tiempo prudente para clamar al Señor y escuchar su voz por medio de la oración y ayuno, hablando con nuestra pareja y escuchar su opinión y consejo, también la de un amigo sabio o de nuestros padres o del pastor, y tomando tiempo para pensar con la cabeza y no con las emociones, que usualmente no son buenas consejeras. Soy Eduardo Rodríguez. Que el Señor te conceda mucha prudencia y sabiduría para guiar tu vida y la de tu familia. ============Joshua 9: The danger of not consulting God Let's see a painful episode when the Israelites were deceived by the Canaanite people.Joshua 9:11-19: Therefore our elders and all the inhabitants of our country spoke to us, saying, ‘Take provisions with you for the journey, and go to meet them, and say to them, “We are your servants; now therefore, make a covenant with us.” ' This bread of ours we took hot for our provision from our houses on the day we departed to come to you. But now look, it is dry and moldy. And these wineskins which we filled were new, and see, they are torn; and these our garments and our sandals have become old because of the very long journey.”Then the men of Israel took some of their provisions; but they did not ask counsel of the Lord. So Joshua made peace with them, and made a covenant with them to let them live; and the rulers of the congregation swore to them.And it happened at the end of three days, after they had made a covenant with them, that they heard that they were their neighbors who dwelt near them. Then the children of Israel journeyed and came to their cities on the third day. Now their cities were Gibeon, Chephirah, Beeroth, and Kirjath Jearim. But the children of Israel did not attack them, because the rulers of the congregation had sworn to them by the Lord God of Israel. And all the congregation complained against the rulers.Then all the rulers said to all the congregation, “We have sworn to them by the Lord God of Israel; now therefore, we may not touch them.---------------------------------------------------Here we see a great painful lesson that the Israelites had to learn. It is the lesson of consulting God in everything!The Gibeonites found a way to deceive them, posing as a very distant people wanting to establish peace deals with them.If Joshua and the leaders of Israel had first consulted the Lord as they had been doing throughout their journey, they would not have fallen into the trap of deception.When we read this, we can see that it was a "hazing" that they committed; for having acted hastily and that perhaps they were carried away by emotion upon hearing those flattering words that spoke very nicely of the God of Israel and the majestic works, or for seeing them with compassion for the pitiful way in which they presented themselves, or for the pleasure to make peace treaties with other distant nations.Whatever the reason, none justified that they had fallen into the trap and put the entire people and God's divine plan at risk. The Gibeonites were converted from enemies to protégés. In the end, they lived among the Israelites doing less attractive jobs like carrying water and firewood for God's temple. We will see later how this did not please God and the great problem that this brought them. But today I want us to reflect on how dangerous it is not to consult the Lord about our actions and decisions. When we are under strong emotions we may regret any word we say or action we do. Be it the purchase of something that is going to take us a long time to pay it on credit, a trip without preparation, getting divorced, or getting married without knowing the person well, etc.Let's ask God and let's put into practice the gift of prudence.Although every problem has its solution and God helps us to get out of difficult situations, the consequences will always be there as scars that remind us of that moment when we disobeyed and hit us hard, leaving unfortunate wounds.It is inevitable to make mistakes, but we can avoid many headaches by taking a prudent time to cry out to the Lord and listen to His voice through prayer and fasting, talking with our partner and listening to their opinion and advice, also that of a wise friend or from our parents or from the pastor, and taking time to think with your head and not with your emotions, which are usually not good advisers. I am Eduardo Rodríguez. May the Lord grant you much prudence and wisdom to guide your life and that of your family.#LibrodeJosue #josue9#KingdomChurch #iglesiaelreino #HomesOfCovenant #ipuh#HogaresDePacto #HogaresDePactoPodcast #PastorCarlos #CarlosRodriguez #eduardorodriguez

In this interview Jolie Root will discuss the challenges many of us face with anxiety and mood disorders. Her message is that nutrition is critical to support the normal structure and function of the nervous system and brain. Everyone needs good nutrition to support all aspects of health. Nutritional shortages can leave us without the resources to maintain, restore and rebuild good health. Jolie gives us good understanding of the importance of omega-3 fatty acids and nutrients such as B-complex vitamins, magnesium, GABA, theanine, 5-HTP and tryptophan. Jolie also discusses her favorite Carlson Labs products for stress and anxiety called Totally Zen. The post 420 – Improving Anxiety and Mood appeared first on Health Quest Podcast.

You must listen to this podcast and learn how certain supplements have the ability to enhance our brain health even as we age. Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here

In this episode, we speak with Jake Gaba. Jake is a student at Stanford's Graduate School of Business, and the owner of Indifferent Broccoli, a video game server hosting and rental company that he bought while taking a year's leave of absence from Stanford. In this episode, Jake and I talk about how he narrowed down his criteria for acquiring a business, the fateful Google search that led him to his first acquisition, his unique process for interviewing interns, what playing video games can teach us about business, and more. LinksIndifferent Broccoli Will Kwan's YouTube ChannelWill's video on the sale of 7D2D Server HostingShameless PlugsJunior to Senior (use code DVY100 to access the course for free)Parsitydev30.xyzPeter's YouTube channel

KSQD 8-17-2022: Dr. Dawn reviews new anticancer drugs and the Medicare and climate change benefits of the Inflation Reduction Act; Do sulfur supplements help joint pain with aging? Update on Monkeypox pandemic and vaccine; Perverse incentives can subvert new medical economic models; Good sleep hygiene supports the immune system

Episode 106: Weight Loss Meds. Anti-obesity medications are FDA-approved drugs to support your patient's efforts to lose weight. It is important for primary care providers to learn about these medications to continue fighting against obesity in our communities.Introduction: Obesity is a chronic disease.By Hector Arreaza, MD. Obesity has all the characteristics of a chronic disease. Let's use our imagination and think about a patient with hypertension, for example. Let's imagine you are the doctor or Mr. Lee. He is 45 years old and his blood pressure has been persistently high, around 150/100, even after lifestyle modifications. You decide to start chlorthalidone 25 mg and Mr. Lee takes chlorthalidone every day. Four weeks later you see Mr. Lee again and you review his labs with him. He has normal renal function and normal electrolytes. His blood pressure is now 119/75. He is feeling great and reports no side effects to chlorthalidone. Would you stop the medication at this time? Think about it. The most obvious answer is NO, you will not stop chlorthalidone. Today you will listen to a discussion about anti-obesity medications, common indications, contraindications, cautions, and more. We will learn that obesity requires chronic treatment with medications just like any other chronic disease. I hope you enjoy it.This is the Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.___________________________Weight Loss Meds. By Sapna Patel, MS4; and Danish Khalid, MS$. Ross University School of Medicine. Moderated by Hector Arreaza, MD. S: Hello and welcome back to our nutrition series! If you haven't already listened to our previous episodes, pause this and make sure to give them a listen. We have talked about physical activity, meal plans, and intermittent fasting. Today we are going to talk about the clinical management of obesity, specifically the pharmacotherapy that is used. We will divide these drugs into drugs that reduce food intake primarily acting on the CNS, drugs that reduce fat absorption and medications that are associated with weight gain. D: Can anyone who is considered obese take medications to help them lose weight? Pharmacotherapy should be considered if the patient will be taking the medication in conjunction with the overall weight management program, including changes in eating habits, increased physical activity, and realistic expectations of the medication therapy. Adjuvant pharmacologic treatments should be considered for patients with a BMI >30 kg/m2 or with BMI >27 kg/m2 who have concomitant obesity related diseases. A: You are going to find doctors who are pretty much against anti-obesity drugs, but that's not my case.  S: Drugs that reduce food intake primarily acting on the CNS: Let's start with Phentermine and other sympathomimetic drugs A: Phentermine has been in the market over 60 years and it is well tolerated by most patients. It is effective, expect 5-8 lbs weight loss a month when taken with dietary changes and increased physical activity. The weight loss happens mostly the first 3-6 months when you take anti-obesity medications. S: One of the longest clinical trials of the drugs in this group lasted 36 weeks and compared placebo treatment to treatment with continuous phentermine and intermittent phentermine. Both the continuous and intermittent phentermine therapy produced more weight loss than placebo. D: Other options are Phentermine and topiramate ER which is known as  “Qsymia”. These drugs combine a catecholamine releaser and anticonvulsant respectively.  Topiramate is currently approved by the USFDA as an anticonvulsant for treatment of epilepsy and for prophylaxis of migraine headaches. Weight loss was seen as an unintentional side effect during clinical trials for epilepsy.The mechanism responsible for this is thought to be mediated through the modulation of GABA receptors, inhibition of carbonic anhydrase and antagonism of glutamate to reduce food intake The common adverse effects include cognitive impairment, paresthesia, and increased risk for kidney stones. Topiramate is also a teratogenic drug, so patients need to be in a good birth control to take it. It causes cleft palate in the fetus.The 2 phase-III trials called EQUIP and CONQUER, both 1 year randomized  placebo-controlled double-blinded clinical trials, 3 different strengths of a once-a day formulation were tested: full strength dose (15 mg of phentermine and 92 mg of topiramate ER), mid-dose (7.5mg of phentermine and 92 mg topiramate ER) and low dose (3.75mg of phentermine and 23 mg of topiramate ER). Subjects  randomized to the full strength dose in EQUIP and CONQUER trials lost an average of 10.9% and 9.8% body weight in 1 year compared to 1.6% and 1.2% loss for placebo subjects respectively. Significant improvement in fasting glucose, insulin, Hemoglobin A1C and lipid profile were seen.Due to the dose dependent side effects of the medications an initial dose of 3.75/23 mg is prescribed daily for the first 14 days then increased to 7.5/23mg daily. These patients should be re-evaluated after 3 months. If 3% weight loss is not achieved by that time, either discontinue or escalate the dose to 15/92mg for 12 weeks. S: Drugs that reduce fat absorption:Orlistat. What is orlistat? Well it's a selective inhibitor of pancreatic lipase that reduces the intestinal digestion of fat. The mean weight loss when compared to a placebo was 2.51kg at 6 months and 2.75kg at 12 months. A: It is one of the few anti-obesity medications approved to be used in children 12 years and older. D: GLP-1 Receptor Agonist (-glutide): Semaglutide and Liraglutide - Only two that have been approved for treatment of obesity. A 20-week randomized trial, comparing Liraglutide, placebo, and orlistat, showed that patients assigned to liraglutide lost significantly more weight than those assigned to both. When compared to placebo, those on liraglutide lost a mean weight loss of 2.8 kg. Whereas compared to orlistat lost an average of 5.8kg, however this was on the higher doses of liraglutide. A 56-weeks trial, comparing liraglutide with placebo, showed a mean weight loss was significantly greater in the liraglutide group (8.0 kg vs 2.6 kg). Furthermore, those who initially lost weight with diet and exercise, a greater proportion of those taking liraglutide maintained the weight loss.  Similarly, clinical trials favored semaglutide, with a weight loss greater in the semaglutide group versus placebo. For both, weight loss occurred in patients with and without diabetes. Note: Semaglutide: once a week. Helps induce weight loss. Liraglutide: daily.  A: We dedicated a whole episode on Semaglutide and another whole episode on Tirzepatide. Tirzepatide (dual agonist: GLP-1 and GIP) seems promising for weight loss and it is likely to be approved soon for obesity treatment. So, when do we discontinue anti-obesity medications? We can ask the same question for other chronic diseases: When do we stop medication for hypertension or diabetes? When we have a patient is unable to keep their weight off, we can't see him/her as someone who has lost their motivation to keep their weight off. Really what's happened is that their hormones have changed in a way that is promoting weight gain and it's very hard to lose weight. We should be at the patient's side to fight it off. Conclusion: Now we conclude our episode number 106 “Weight Loss Meds.” Phentermine is the most widely used anti-obesity medication. It is a stimulant, and it is a safe and effective medication for most patients who are fighting obesity. Make sure you learn the contraindication, side effects, and precautions when you prescribe it. Also, learn about other meds that are very effective, including GLP-1 receptor agonists, and your patients will thank you. This week we thank Hector Arreaza, Danish Khalid, and Sapna Patel. Audio by Sheila Toro.Thanks for listening to Rio Bravo qWeek Podcast. If you have any feedback, contact us by email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References: Perreault, L., Apovian, C. (2021). Obesity in adults: Overview of management. Pi-Sunyer,  F.X., Seres, D., & Kunins, L. (Eds.) Uptodate. Available from: https://www-uptodate-com.rossuniversity.idm.oclc.org/contents/obesity-in-adults-overview-of-management?search=weight%20loss%20medications&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2 Perreault, L. (2022). Obesity in adults: Drug therapy. Pi-Sunyer,  F.X., & Kunins, L. (Eds.) Uptodate. Available from: https://www-uptodate-com.rossuniversity.idm.oclc.org/contents/obesity-in-adults-drug-therapy?search=weight%20loss%20medications&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 Dungan, K., DeSantis, A. (2022) Glucagon-like peptide 1-based therapies for the treatment of type 2 diabetes mellitus. Nathan, D.M., & Mulder, J.E. (Eds.) Uptodate. Available from: https://www-uptodate-com.rossuniversity.idm.oclc.org/contents/glucagon-like-peptide-1-based-therapies-for-the-treatment-of-type-2-diabetes-mellitus?search=glp%201%20receptor%20agonists&source=search_result&selectedTitle=2~97&usage_type=default&display_rank=1 Perreault, L., Bessesen, D. (2022). Obesity in adults: Etiologies and risk factors. Pi-Sunyer,  F.X., & Kunins, L. (Eds.) Uptodate. Available from: https://www-uptodate-com.rossuniversity.idm.oclc.org/contents/obesity-in-adults-etiologies-and-risk-factors?search=medication%20associated%20with%20weight%20gain§ionRank=1&usage_type=default&anchor=H1612312650&source=machineLearning&selectedTitle=1~150&display_rank=1#H1612312650. Royalty-free music used for this episode: Salsa Trap by Caslo, downloaded on July, 20, 2022 from https://freemusicarchive.org/music/caslo/caslo-vol-1/salsa-trap/. Space Orbit by Scott Holmes, downloaded on July, 20, 2022 from https://freemusicarchive.org/music/Scott_Holmes/.  

Not medical licensed advice . Always consult with your doctor:New Treatments For ObesityBMI: 25-30 : overweight  >30 ObeseWHO 2016 40% are over weight and 13% obese slightly higher in females . This is triple that in 1975UK 2019 House of Commons Library  40% are overweight and 30% obese higher in middle aged and elderly menNHS 2021: Children Obesity has gone up in 12 years from 19% to 25% The Surprising Link Between Chronic Inflammation & Obesity—Plus What You Can Do About ItMay 5th 2021Leptins are hormones produced by adipocytes that communicate with the hypothalamus to reduce eating. If you have too much leptin you become leptin resistant and do not stop eating. High leptin levels are also associated with  chronic inflammation.Conversely losing weight reduces systemic inflammation. REVIEW articleFront. Physiol., 29 January 2020Sec. Clinical and Translational PhysiologyChronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 DiabetesFrederika ZatteralThe key mediator of inflammation in obesity is the innate immune system cell the macrophage that can account for up to 40% of adipose tissue and it differentiates into a pro-inflammatory M1 macrophage setting up chronic inflammation.Obesity and Inflammation: A Vicious CycleDoes obesity cause inflammation or does inflammation lead to obesity?Jun 25, 2020Jennifer LutzObesity causes chronic inflammation via a chronic immune reaction initiated in the adipose tissue but inflammatory cells can go round the body. In addition gut inflammation may be a result also of the poor diet that led to the obesity.We know that obesity has tripled in the last 50 years such that 40% of the western world are obese. In fact 75% are prediabetic.Cardiovascular disease leading to cardiac disease and strokes, diabetes, cancer, depression, osteoarthritis all feed back and make it more likely you will continue to be obese.Higher adiposity and mental health: causal inference using Mendelian randomization Francesco Casanova,Jessica O'Loughlin,Susan Martin,Robin N Beaumont,Andrew R Wood,Edward R Watkins,Rachel M Freathy,Saskia P Hagenaars,Timothy M Frayling,Hanieh Yaghootkar... Show moreAuthor NotesHuman Molecular Genetics, Volume 30, Issue 24, 15 December 2021, Pages 2371–2382, There is a bidirectional relationship between depression and obesity.Genetic sorting showed that it is obesity per se and not the metabolic unhealthiness due to the obesity such as diabetes that leads to depression.That said diabetes from obesity causes depression although obesity itself causes systemic inflammation which is an independent risk factor for depression and cancer.There are also huge psychosocial effects of obesity on mood.Once-Weekly Semaglutide in Adults with Overweight or ObesityNew England Journal Of Medicine March 2021John P.H. Wilding,Once a week subcutaneous Semaglutide reduced weight by up to 20%Semaglutide is a GLP-1 agonist so suppresses Glucagon and increases insulin hence controlling blood sugar. It also slows gastric emptying  increasing satiety and acts on Receptors in the Arcuate Nucleus in the brain to increase satiety.It is already licensed to treat Type 2 diabetes.It also reduces the risk of cardiovascular complication in Type 2 diabetes and at a cellular level reverses atherogenesis. There is a question on worsening the risk of retinopathy.Other GLP-1 agonists : Liraglutide Setmelanotide.CpdFDA Approved Medication for treating ObesityPhentermine, diethylpropion,benzphetamine, phendimetrazine , Orlistat, Phentermine/topiramate Qsymia, Bupropion/naltrexone, Semaglitide, Liraglutide, setmelanotideCpd Phentermine-topiramate: First combination drug for obesityInt J Applied Med Res 2015Singh et alPhentermine is a centrally acting sympathomimetic that reduces appetite and topiramate enhances GABA ergic transmission reducing Dopamine Response to food.This combination causes up to 10% weight loss maintained in 50% for 2 years.The relationship between early weight loss and weight loss maintenance with naltrexone bupropion therapy.THe Lancet Discovery Science 2022Le Roux et alNaltrexone blocks opiate receptors and bupropion (wellbutrin/zyban) blocks reuptake of dopamine  -reward pathways- .and noradrenaline . Weight loss is maintained at 1 yearBoth medications enhance each other on feeding and satiety

Te voy a contar desde mi experiencia los aspectos positivos y negativos del clonazepam, como evitar caer en dependencia de él. En este video te cuento mi historia con las medicinas psiquiátricas, la cual no fue buena, principalmente por que me los habían administrado mal. Solo antidepresivos o solo benzodiacepinas, es decir calmantes como el clonazepam. Clonazepam ¿Qué es? El clonazepam es un Calmante, de la familia de las Benzodiacepinas, que son sustancias que elevan un neurotransmisor llamado GABA, la cual te ayuda a relajarte, afloja los músculos y te ayuda a dormir bien. Pero tienen gran potencial de adicción, si se toman sin la supervisión de un médico. Por esa razón son medicamentos controlados y solo se pueden adquirir con fórmula médica. Tienen estrictos controles. Recomendación: Si estás tomando clonazepam, hazlo por un tiempo limitado (1-2 meses) y déjelo de forma gradual para no tener efectos secundarios ni ser dependiente de este. Y siempre que sea administrado por un psiquiatra o neurólogo. En este vídeo te cuento mi experiencia con el clonazepam y como se puede evitar caer en la dependencia. Enlaces mencionados en el video (audio) Los 2 Errores más Comunes al Tomar Medicinas Psiquiátricas para la Ansiedad https://www.youtube.com/watch?v=K6VVeZEdAgU MEDICACIÓN PARA ANSIEDAD: CÓMO TOMARLA Y NO TOMARLA CON EL DR. IÑAKI VAZQUEZ https://www.youtube.com/watch?v=WNzoK6W82j8 Estuve secuestrado por 3 horas- como manejar estas situaciones experiencia real https://www.youtube.com/watch?v=_AiYEvjdJyQ Video Sobre el Clonazepam con el psiquiatra Felipe Merino- pros y contras https://nelsonarturopsicologo.com/clonazepam-rivotril-para-ansiedad-todo-debes-saber-psiquiatra-felipe-marino/ Enlaces y videos de interés para ayudarte a superar la ansiedad 3 EJERCICIOS PARA CURARTE DE LOS PENSAMIENTOS NEGATIVOS Y DESINTOXICAR TU MENTE https://www.youtube.com/watch?v=b1YBDxgWPgI Ejercicios masajes para quitar mareos https://www.youtube.com/watch?v=5YUIkZLBmq0 Tu si te vas a curar de la ansiedad definitivamente https://www.youtube.com/watch?v=paudc4XWuF4 Acufenos y tinnitus, cómo curarlos https://www.youtube.com/watch?v=J-Bg7T1VCBU Como superar un ataque de pánico – Guía definitiva https://www.youtube.com/watch?v=qI74HmvI3sk&t=18s 7 pasos par asuperar un atque de pánico (versión 2017) https://nelsonarturopsicologo.com/7-pasos-superar-panico/ Probando CBD – Como elegir el mejor para la Ansiedad https://www.youtube.com/watch?v=-x2Gkcdepas Como saber si tengo ansiedad o depresión- 4 test psicológicos https://www.youtube.com/watch?v=iOFz79lmlMM El psicólogo más famoso en Hispanoamérica Rafael Santandreu te dice como Curar la ansiedad https://www.youtube.com/watch?v=9LJ2kdFcHTs&t=27s Nueva respiración para ataques de pánico https://nelsonarturopsicologo.com/res... El Origen de la Ansiedad https://cutt.ly/sIXTNaT La Cura definitiva para la Ansiedad https://cutt.ly/OIXTVMl – El mejor ejercicio para la Ansiedad https://cutt.ly/dIXTXPg • Datos de contacto Página web: https://nelsonarturopsicologo.com/ Instagram: https://cutt.ly/vIXYOnX Facebook: https://cutt.ly/iIXYP1T Twitter: https://twitter.com/libre_ansiedad LinkedIn: https://www.linkedin.com/in/nelson-arturo/ Whatsapp: +57 3117606107

...the first Soulful Saturday session for August, and it's an afternoon thing for yours truly today, after the tech gremlins bite me again!! Some sublime soulful, deep, broken and jazzy niceness for you today - enjoy!!Track-listing:Sounds Signals - Stevie's Groove (Original Mix)Alexny - Saxiest Part (Original Mix)Emmaculate - Voodoo (Shannon Chambers 1Sound Remix)Themba (SA) feat. J-Something - Colours (Rocco Rodamaal Extended Remix)Tortured Soul - Your Body Doesn't Lie (Fka Mash Re-glitch Club Mix)N'dinga Gaba feat. Sahffi - Summer Breeze (Fka Mash Re-glitch)Mike Delgado - Little Pieces (Vocal Mix)Babs Presents - Jazz Nights In E15 (Original Mix)Dirtytwo - Micke Pettersson (Crackazat Remix)Kerri Chandler feat. Dora Dora - Who Knows (Barbarellas)(Media Vocal Mix)Mike Lindup & Dave Lee ZR - Atlantia (Dave Lee's Extended Mix)Brian Jackson - Little Orphan Boy (Two Soul Fusion Extended Remix)Sean Khan – Starchild (Kaidi Tatham Remix)Jab – DirectionsAfro Warriors & Dorivaldo Mix feat. Miranda Nicole – Don't Look Away (David Morales Mix)Ed Ramsey, Big Logan & DAVID LALLA - Sunshine (Main Mix)Brettina - Spell (Reel People Remix)Eric Kupper feat. SP - The Inside (Original Mix)…and here's the download link:https://www.sendspace.com/file/iboe69…hope you enjoy – as always, thanks to all who locked on…https://pressureradio.com

And the whole congregation of the children of Israel assembled together at Shiloh, and set up the tabernacle of the congregation there. And the land was subdued before them.2 And there remained among the children of Israel seven tribes, which had not yet received their inheritance.3 And Joshua said unto the children of Israel, How long are ye slack to go to possess the land, which the Lord God of your fathers hath given you?4 Give out from among you three men for each tribe: and I will send them, and they shall rise, and go through the land, and describe it according to the inheritance of them; and they shall come again to me.5 And they shall divide it into seven parts: Judah shall abide in their coast on the south, and the house of Joseph shall abide in their coasts on the north.6 Ye shall therefore describe the land into seven parts, and bring the description hither to me, that I may cast lots for you here before the Lord our God.7 But the Levites have no part among you; for the priesthood of the Lord is their inheritance: and Gad, and Reuben, and half the tribe of Manasseh, have received their inheritance beyond Jordan on the east, which Moses the servant of the Lord gave them.8 And the men arose, and went away: and Joshua charged them that went to describe the land, saying, Go and walk through the land, and describe it, and come again to me, that I may here cast lots for you before the Lord in Shiloh.9 And the men went and passed through the land, and described it by cities into seven parts in a book, and came again to Joshua to the host at Shiloh.10 And Joshua cast lots for them in Shiloh before the Lord: and there Joshua divided the land unto the children of Israel according to their divisions.11 And the lot of the tribe of the children of Benjamin came up according to their families: and the coast of their lot came forth between the children of Judah and the children of Joseph.12 And their border on the north side was from Jordan; and the border went up to the side of Jericho on the north side, and went up through the mountains westward; and the goings out thereof were at the wilderness of Bethaven.13 And the border went over from thence toward Luz, to the side of Luz, which is Bethel, southward; and the border descended to Atarothadar, near the hill that lieth on the south side of the nether Bethhoron.14 And the border was drawn thence, and compassed the corner of the sea southward, from the hill that lieth before Bethhoron southward; and the goings out thereof were at Kirjathbaal, which is Kirjathjearim, a city of the children of Judah: this was the west quarter.15 And the south quarter was from the end of Kirjathjearim, and the border went out on the west, and went out to the well of waters of Nephtoah:16 And the border came down to the end of the mountain that lieth before the valley of the son of Hinnom, and which is in the valley of the giants on the north, and descended to the valley of Hinnom, to the side of Jebusi on the south, and descended to Enrogel,17 And was drawn from the north, and went forth to Enshemesh, and went forth toward Geliloth, which is over against the going up of Adummim, and descended to the stone of Bohan the son of Reuben,18 And passed along toward the side over against Arabah northward, and went down unto Arabah:19 And the border passed along to the side of Bethhoglah northward: and the outgoings of the border were at the north bay of the salt sea at the south end of Jordan: this was the south coast.20 And Jordan was the border of it on the east side. This was the inheritance of the children of Benjamin, by the coasts thereof round about, according to their families.21 Now the cities of the tribe of the children of Benjamin according to their families were Jericho, and Bethhoglah, and the valley of Keziz,22 And Betharabah, and Zemaraim, and Bethel,23 And Avim, and Pharah, and Ophrah,24 And Chepharhaammonai, and Ophni, and Gaba; twelve cities with their villages:25 Gibeon, and Ramah, and Beeroth,26 And Mizpeh, and Chephirah, and Mozah,27 And Rekem, and Irpeel, and Taralah,28 And Zelah, Eleph, and Jebusi, which is Jerusalem, Gibeath, and Kirjath; fourteen cities with their villages. This is the inheritance of the children of Benjamin according to their families.

Dr. Carmen discusses Progesterone and how it impacts our mental health. How this hormone is connected to some many other processes. We talk about Dopamine and GABA and how progesterone impacts these neurotransmitters. Men and women BOTH need healthy levels of progesterone to have optimal physical and mental health. If you want to take this work deeper, apply it to your life we invite you to join us in the New Beginnings Program. We take this work apply it to your daily life, practice it. Unwinding the beliefs that don't serve you and go to work creating ones that move your life to that place you want it to be. Click here for more information: https://www.kimberlyjarmancoaching.com/the-path-to-success-program/ If you are ready to jump in click here to schedule a complimentary consultation call: https://calendly.com/kimberlyjarmancoaching/free-consultation-call For more information about working with Dr. Carmen Jones ND https://www.drcarmenjones.com For more information about working with Life Coach Kimberly Jarman https://www.kimberlyjarmancoaching.com

DA takes Mraz behind the scenes of last week on Baltimore. Bogusch and Mraz discover Pete's strength as a boss. 

DA takes Mraz behind the scenes of last week on Baltimore. Bogusch and Mraz discover Pete's strength as a boss. 

...this morning's "Risin' " session goes out to all those "going through a thing" - I send love, light, peace and blessings via the healing power of music...and remember, we are never alone...listen, let the selection work its magic, and enjoy!!Track-listing:Kiko Navarro feat. Dana Mamam - Ogun In Ta Ete We (She Is Calling) (Original Mix)Aaron Sevilla, Mijangos, Toth De La Vega & MixJay - Coketa (Extended Mix)Kato Change, Winyo & SURAJ - Suna (Da Africa Deep Afrikan Remix)Dany Cohiba - Church Soul Preacher (Original Mix)Kem - Jesus (Muzikman Edition Blood Of Jesus Remix)Sean Smith & Lafayette Parker - It's True (Original Vocal)Inaya Day & Alex Poet - Love Language (DJ Spen & Reelsoul Back To Da 95 Remix)Ronnie Herel feat. Omar - A Night We Dream Of (DJ Spen & Reelsoul Remix)Tortured Soul - Your Body Doesn't Lie (Fka Mash Re-glitch Club Mix)N'dinga Gaba feat. Sahffi - Summer Breeze (Fka Mash Re-glitch)Oyobi feat. Karen Lee Andrews - Make Me Believe In You (12” Version)Midnight Roba – Safe With Me (2000Black Remix) Trian Kayhatu – Red Onion White GarlicWaajeed feat. DeSean Jones & Khristian Foreman - Abracadabra Contours – North West (Kaidi Tatham Remix)Luman Child - Grateful (Orchestral Mix)Mike Lindup & Dave Lee ZR - Atlantia (Dave Lee's Extended Mix)Mr. Moon - Love Of Mine (Richard Earnshaw SugarSoul Remix)Duwayne Motley feat. Andrea Brown - Hand In Hand (Extended)NATE08 - Sunrise Sunfall…and here's the download link:https://www.sendspace.com/file/8nzh8x…hope you enjoy – as always, thanks to all who locked on…https://pressureradio.com

On this Friday edition of Glenn Clark Radio, Glenn and Griffin discuss the Orioles winning again yesterday over the Rays with Stan ‘the Fan' Charles who joins the boys in studio this morning. The Orioles continue to keep themselves within Wild Card contention, which poses a lot of questions as we keep getting closer to the August 2 trade deadline, plus, Glenn and the boys will talk about the latest Lamar Jackson and Ravens news as training camp rolls on. At 10:30am, we will have a chat with USA Today baseball columnist, Gabe Lacques, who wrote about the Orioles rebuild yesterday and we'll get his thoughts on the Orioles success and how the team should manage its assets at the deadline. At 11am, we will talk with Sonsy Gaba after an emotional day at Camden Yards during the celebration of Mo Gaba Day. At 11:30am, we will chat with Mike Sando of the Athletic about his yearly QB rankings, some Lamar Jackson and more. All that and much, much more on today's Friday edition of the program.

In this episode, Dr. Levit joins us to discuss T1D remission and beta cell regeneration, induced by oral administration of combo of DDP-4 inhibitor, PPI and GABA in NOD mice and human patients.  Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!  https://thesugarscience.org/ask-the-expert/

Summary In this episode, Dr. Ameet shares in depth about liver health and liver function. how the liver impacts thyroid function, inflammation, hormonal imbalances, mood. He shares about herbs, supplements, techniques and exercises for liver detox and liver support. He also talks about the connection with emotional trauma. Three things you will learn this episode: Liver Function in details. How the liver works, its role for overall health and how to take care of it. The connection between Liver function and Brain chemicals, leading to Anxiety and Depression. Liver Stagnation Symptoms and how to take care of it. Timestamps [01:30] Dr Ameet Curriculum [03:30] Dr Ameet activities in Kenya, Charity projects and Mobile Clinic. [06:48] Why Dr Ameet calls the Liver the hidden Master Organ. [09:00] Neurotransmitters connected to Anxiety and Depression. [10:30] Leaky gut connected to Liver stagnation. [18:00] Body reaction to stress. [24:00] Liver Stagnation symptoms. [34:00] Breathing Practices for Liver health. [46:00] Lymphatic system in connection with Liver Function. [56:00] Neuroplasticity and the impact on the body. [58:00] How therapy can help with liver function and stress relief. [60:00] Family Constellation Therapy. Takeaways In Chinese medicine we call the Liver the master organ because it's really responsible for most of the functions in your body including blood purification, detoxification of drugs and toxins and also detoxifies the toxins that are produced by your body itself. Your liver also produces a lot of enzymes, produces bile, so it's responsible for a lot of your digestion, hormone production, protein production and it also helps with blood sugar storage and regulation. Not only that, it helps with immune cell activation and storage of vitamins and iron. Most people with anxiety do suffer with some level of adrenal fatigue. So if you have more inflammation in the body from a sluggish liver that means your adrenal glands have to work harder to produce cortisol, and so you basically burn your adrenal glands out even more. And with a cortisol imbalance that comes from adrenal fatigue you end up suppressing neurotransmitters such as GABA, serotonin, dopamine and melatonin - all related to anxiety and depression. Family constellation is a system of therapy where you look at the influence of past generations on your condition now. So you were born into a system, a family system, and that system carries ... basically it is affected by the behaviors of your grandparents and their great-grandparents because the behaviors of your great-grandparents affected how your grandparents behaved and your parents behaved, right? And all these behaviors influence the entire system. Links Dr. Ameet's Free Holistic Medicine Courses Online & eBooks | Therapy Sessions: Holistic Medicine Doctors Watch the full Video on Dr Ameet YouTube Channel!

Summary Dr Ameet talks on how to heal the body by considering mind and body as one. He explains in details how the digestive system health is essential to maintain good overall health and mental health. He also talks about liver function and shares a long list of remedies, herbs and supplements for the issues he talked about. Three things you will learn this episode: How food, medications and lifestyle affect your emotions. How your digestive system and adrenal glands work. Supplements and remedies for healing inflammation, gut, liver, adrenals and more. Timestamps [01:00] Intro to the podcast and course. [03:00] What affects your emotions? [04:09] How your digestive system works. [06:30] Food and hormones. [08:00] Adrenal system and adrenal fatigue. [09:00] How to heal inflammation in the gut. [12:30] Liver function. [14:00] Bile function and constipation. [16:40] Liver and Lactate connected to anxiety. [18:30] Thyroid function. [20:30] More supplements and homeopathy. [22:00} A true story. Takeaways What affects your emotions? Number one is life experiences, stress, traumatic memory, abuse, beliefs - all that will affect your mind and contribute to anxiety and depression. The other thing what you got to realize that's affecting your emotions is diet and nutrition, so poor diet, eating too many inflammatory foods and I'll talk about that next, environmental toxins, blood sugar imbalance with eating too many carbs and just binge eating, you're going to go through ups and downs in your blood sugar levels which will give you anxiety and depression. When you damage your intestines, of course, less serotonin, less GABA is produced as well because all those good bacteria that produce these good brain chemicals are gone. And now, when you have inflammation in your body because of all the toxicity and all the immune response to the exposed food particles your body says, "I've got to produce cortisol to manage this inflammation." And the organ that produces cortisol is your adrenal system. Why is your liver important? Because it helps with blood purification, detoxification - detoxification of drugs, medications and even the toxins that your body produces when it's trying to process your foods and other chemical reactions in your body, your liver also produces bile which is basically it helps detoxify your body so it produces this juice and it releases that juice into your intestines. Bile is very, very, very important for digestion as well - it helps break down fats and other nutrients. So remember that certain vitamins require fat to be absorbed. If you cannot break down your fat really well then you're also not absorbing these important vitamins, so that's going to affect your brain chemicals. So bile is needed for digestion. Links Dr. Ameet's Free Holistic Medicine Courses Online & eBooks | Therapy Sessions: Holistic Medicine Doctors Watch the video of this podcast on Dr Ameet YouTube Channel!

Hello babies! How do you feel about self-checkout at stores? We were shocked by the abundance of positive sentiment online. Please share your feelings with us either way! On today's ep, Lisa tries to convince Emily to adopt her hobbies, and Emily reveals her shoe size. On Wiki of the Week, we read the Wikipedia page for Cynthia (Gaba girl), an unusually natural and human looking mannequin.

...another Saturday morning, and another gorgeous summer day - this "Risin' " session again reflects that - the soulful, deep and broken goodness is all about a summertime vibe - so find a good place, listen and enjoy!!Track-listing:N'dinga Gaba feat. Sahffi - Summer Breeze (Fka Mash Re-glitch)NATE08 - Sunrise SunfallSounds Signals - Stevie's Groove (Original Mix)Groove Thing - Wadaumean (Marco Corvino & Bill Ware Mix)Stagz Jazz, Rosa Kay & Victor Matalane - This Love (Original Mix)MindState feat. Tess Leah - For You (Original Mix)Artwork Sounds, CocoSA & Russell Zuma - Woza MoyaJavonntte feat. musclecars - House GrammyDuwayne Motley feat. Andrea Brown - Hand In Hand (Extended)Mr. Moon - Love Of Mine (Richard Earnshaw SugarSoul Remix)Mike Lindup & Dave Lee ZR - Atlantia (Dave Lee's Extended Mix)John Briggs – Smoke & Ceremony (II)Sy Sez feat. Natural Wright – We Will Rise (Original Mix)Exte C feat. Rhey Osborne – Earth And Venus (Monodeluxe Deep Vibe Mix)Silhouette Brown – Pain (It's Gonna Come Harder)30/70 feat. Athlete Whippet – N.Y.P. (SAUL Remix)Hadiya George – Hot Flavor (Kaidi Tatham Extended Remix)Benny Sings - SummerludeAaron Sevilla, Mijangos, Toth De La Vega & MixJay - Coketa (Extended Mix)Kiko Navarro feat. Dana Mamam - Ogun In Ta Ete We (She Is Calling) (Original Mix)Kato Change, Winyo & SURAJ - Suna (Da Africa Deep Afrikan Remix)Dany Cohiba - Church Soul Preacher (Original Mix)…and here's the download link:https://www.sendspace.com/file/uiq2fv…hope you enjoy – as always, thanks to all who locked on…https://pressureradio.com

  My podcast guest this week is Lindsey Beveridge who I met 7 years ago at a "how to quit drinking" workshop in London!  We were both hungover and grumpy so we didn't even connect on that day so it's been amazing to meet her again here in Soberland.  Shout out to Club Soda who ran that workshop as we are both 7 years sober now!  Not only are we sober but we both help other people to quit drinking and then to go on and thrive in their sobriety.  Lindsey qualified as a nutritionist in 2019 and helps people to implement changes to their diet and lifestyle so they can feel better.  She uses a functional medicine approach to enable her clients to change their patterns of behaviour. In this Episode Lindsey was a teenage drinker and enjoyed the confidence it gave her Like many of us her drinking got heavier as she got older until she became dependent At the age of 47 she was taking “Are You an Alcohol?” quizzes and ticking all the boxes Her excessive drinking began to frighten her and as a single parent she feared that her young daughter might find her dead one day Lindsey realised that she should go for a medically assisted detox but she was afraid to do this in case her daughter was taken away from her She tapered off her drinking to avoid the worst of the withdrawal symptoms but she would not recommend tapering to anyone We discussed how difficult tapering is and how similar it is to the moderation battle In retrospect she realises she should have gone to rehab for a detox We agreed that for anyone with a serious drinking problem Rehab for a week and then connecting with a community to keep them on track was the best strategy I always say to people that for the first few months they need to make their sobriety a priority and “throw the book at it” and Lindsey certainly did that! As you heard she listened to podcasts, read books, did yoga, ate well and spent quality time with her daughter. Lindsey agreed that we need projects to keep the dopamine triggered in early sobriety – for Lindsey it was exercise, learning new things and voluntary work that kept her happy. She used this time to explore lots of different things and during that exploration she found some things that she absolutely loved. Early sobriety is indeed a journey of self discovery and here at Tribe Sober we've set up a 7-step journey for our members - so they can try out things like coaching, yoga, hypnotherapy, meditation, art therapy - either for free or at significantly discounted rates.  Just CLICK HERE and check out what we can offer you. Year 1 was tough for Lindsey – she was tired all the time – nutritionally lacking with gut issues – so she had to build herself up again Year 2 was about dealing with the underlying trauma that she'd been drinking away for years – she went through a lot of intense therapy but By Year 3 it was done a dusted and she felt great! This is so important to hear for those people who have been sober for a while but don't really feel they are thriving or enjoying life more – the message here is to be patient Remember how long you've been drinking for and remember the guideline we learned from Dr Dawn (podcast number 61 – Sept 2021) – From her extensive experience as a rehab doctor Dawn has observed that it takes a month of recovery for every year that we drank for all of the benefits to manifest As you do the maths and come up with 40 months (as in my case) don't be discouraged as you will start to feel better almost immediately and of course for those people who are already a couple of years sober this is great news as it means that the benefits will just keep coming! Lyndsey is a qualified and experienced nutritionist so she gave us some really useful advice about:- Menopause – drinking during menopause will disrupt our endocrine system and make us more oestrogen dominant which can lead to breast cancer – that's a fact that I wish I'd learned before I got my breast cancer! In fact alcohol disrupts all our hormones, it throws out our thyroid, it affects our insulin levels and also prevents us from absorbing vital nutrients from our food. The resulting nutritional deficiency affects our DNA replication and repair which of course has implications for cancer As Lyndsey explained taking a handful of supplements will do nothing if we are drinking – the alcohol will simply cancel out any benefits – a bit like taking meds and drinking. Of course we talked about gut health – the fact that alcohol affects not only our gut lining but also the microbiome which in turn affects many other parts of our body Another interesting fact that I learned from Lyndsey was the fact that some of us have naturally low levels of dopamine so we turn to alcohol to make us feel good Other people (including Lyndsey) have low levels of Gaba (the calming neurotransmitter) so will use alcohol to calm themselves down. So in early sobriety we need to build up those neurotransmitters – if we tend to be dopamine deficient we can do more exercise to raise it and if we used alcohol to calm ourselves we need to find calming activities – like yoga, meditation or having or even having a hot bath. We talked about the effect alcohol has on cognitive function – of course we all know that alcohol kills brain cells and the scary fact is that just as women's drinking has increased significantly over the last 40 years, so have the number of dementia cases in the female population. When I asked Lyndsey to list her benefits of sobriety she quite simply said “It changed everything” – she loves her work as a nutritionist, she loves her yoga, she got married and has better relationships. Lyndsey has the most amazing Instagram feed which is packed with information which will help you in that first year of recovery – her Instagram is called recoverynutrition and her website is called www.recovery-nutrition.co.uk/ This episode comes out on 23rd July – Lyndsey is a guest speaker at our Saturday Zoom Café so if you would like to join then just email me at janet@tribesober.com – I will record Lyndsey's talk  so if you cannot attend the live talk I can send you the recording More Info Subscription membership – you can join up HERE. To access our website, click HERE. If you would like a free copy of our “Annual Tracker” or our e-book 66 Days to Sobriety, please email janet@tribesober.com. If you would like to come to our Saturday afternoon Zoom Cafe as a guest and meet our community, just email janet@tribesober.com. Episode Sponsor This episode is sponsored by the Tribe Sober Membership Program.  If you want to change your relationship with alcohol then sign up today Read more about our program and subscribe HERE Book a Discovery Call with me to find out if our membership would help you Help us to Spread the Word! We made this podcast so that we can reach more people who need our help.  Please subscribe and share. If you enjoyed the podcast, then please leave us a 5-star review on Apple podcasts. Take a screenshot of your review, and DM it to Tribe Sober's Instagram page – see PS below for instructions. We'll send you something special to say thank you! We release a podcast episode every Saturday morning. You can follow Tribe Sober on Facebook, Twitter, TikTok and Instagram. You can join our private Facebook group HERE. PS: How to Leave a Rating/Review in Apple Podcasts (on an iOS Device) Open the Podcasts app. EASY. Choose “Search” from the bottom row of icons and enter the name of the show (e.g. Recover Like a Mother) into the search field. Select the show under Shows (not under Episodes). Scroll down past the first few episodes until you see Ratings & Reviews. Click Write a Review underneath the displayed reviews from other listeners. You'll then have the option to rate the show on a 5-star scale and write a review (you can rate without writing too but it's always good to read your experience).

Alright my friends, I can honestly say that magnesium has been a LIFE SAVER for so many years, for a good reason.Magnesium Bolsters Your Biological and Mental HealthOptimal magnesium levels go a very long way when it comes to anything and everything brain-related. Whether you're wanting to wake up feeling alive and energized, focus on the task at hand, remember everything on your daily ‘to do' list, or just get a good night's rest, you need an ample amount of magnesium to accomplish it. In addition to supporting the health of your nerves themselves, magnesium also helps with occasional head tension & discomfort and supports a relaxed mood.  Magnesium is a cofactor in more than 325 enzymatic reactions—in DNA and neurotransmitters; in the bones, heart and brain; in every cell of the body. Unfortunately, a deficiency of this crucial mineral is the most common nutritional deficiency today. Fortunately, supplementation with magnesium is the most impactful integrative supplement  you can turn to, particularly in depression and ADHD.Why is magnesium deficiency so common, and why is restoring the mineral so essential to mental and emotional well-being and behavioral balance? The rest of this dialogue addresses those two questions, and presents aspects of this critical therapeutic approach.Let's Talk Magnesium DeficiencyThe population is deficient in magnesium—found abundantly in whole grains, beans and legumes, nuts and seeds, and leafy greens, as well as cocoa and molasses—for several reasons. 1st: Soil depletion.Intensive agricultural practices rob the soil of magnesium and don't replace it.  As a result, many core food crops—such as whole grains—are low in magnesium. A recent paper put it this way: Magnesium's “importance as a macronutrient ion has been overlooked in recent decades by botanists and agriculturists, who did not regard Mg deficiency in plants as a severe health problem.  However, recent studies have shown, surprisingly, that Mg contents in historical cereal seeds have markedly declined over time, and two thirds of people surveyed in developed countries received less than their minimum daily Mg requirement.”2nd: Food processing. Magnesium is stripped from foods during food processing. For example, refined grains—without magnesium-rich germ and bran—have only 16% of the magnesium of whole grains. [2]3rd: Stress. Physical and emotional stress—a constant reality in our 24/7 society—drain the body of magnesium.  In fact, studies show inverse relationships between serum cortisol and magnesium—the higher the magnesium, the lower the cortisol. Stress robs the body of magnesium—but the body must have magnesium to respond effectively to stress.Other factors. Many medications—such as medications for ADHD—deplete magnesium. So does the intake of alcohol, caffeine and soft drinks.The result: In 1900, the average intake of magnesium was 475 to 500 mg daily. Today, it's 175 to 225 mg daily. Which means that only one-third of adult Americans get the daily RDA for magnesium—320 mg for women, and 420 mg for men. (And many researchers consider the RDA itself inadequate.)  And that magnesium deficit causes deficits in health. Magnesium deficiency has been cited as contributing to brain function, hypertension, type 2 diabetes, obesity, osteoporosis and certain types of cancer. But detecting that deficiency in laboratory testing is difficult, because most magnesium in the body is stored in the skeletal and other tissues. Only 1% is in the blood, so plasma levels are not a reliable indicator. That means a “normal” magnesium blood level may exist despite a serious magnesium deficit. An effective therapeutic strategy: Assume a deficit is present, and prescribe the mineral along with other appropriate medical and natural treatments.  That's particularly true if an individual has symptoms such as anxiety, irritability, insomnia and constipation, all of which indicate a magnesium deficiency.I Say We Rename it: The Mind MineralSome of the highest levels of magnesium in the body are found in the central nervous system, with studies dating back to the 1920s showing how crucial magnesium is for a balanced brain…It's known, for example, that magnesium interacts with GABA receptors, supporting the calming actions of this neurotransmitter. Magnesium also keeps glutamate—an excitatory neurotransmitter—within healthy limits. Individuals with higher magnesium levels also have healthy amounts of serotonin - which is all made in the gut.And further, the synthesis of dopamine requires magnesium.  THis is critically important if you have ADHD. In summary, the body needs magnesium to create neurotransmitters (biosynthesis) and for those neurotransmitters to actually transmit. Magnesium also acts at both the pituitary and adrenal levels. In the pituitary gland, it modulates the release of ACTH, a hormone that travels to the adrenal glands, stimulating cortisol release. In the adrenal gland, it maintains a healthy response to ACTH, keeping cortisol release within a normal range. As a result, magnesium is a must for maintaining the homeostasis of the HPA axis. Given all these key mechanisms of action, it's not surprising that a lack of the mineral can produce psychiatric and other types of problems.  A person may have: Difficulty with memory and concentration. Depression, apathy and fatigue. Emotional lability. Irritability, nervousness and anxiety. Insomnia. Migraine headaches. Constipation. PMS. Dysmenorrhea. Fibromyalgia. Autism. ADHD. Fortunately, studies show that magnesium repletion—restoring normal levels of the mineral—produces positive changes in mood and cognition, healthy eating behavior, healthy stress responses, better quality of sleep, and better efficacy of other modalities, such as medications. Enjoy the episode.  If you need support sorting through what brand and product is best for you, please do reach out and I'll walk you through an assesment to determine the best options for you!xo Kassandra

Download the cheat: https://bit.ly/50-meds  View the lesson: https://bit.ly/DivalproexDepakoteNursingConsiderations    Generic Name Divalproex Trade Name Depakote Indication Seizures, manic episodes, prevention of headache Action Increases the level of GABA (inhibitory neurotransmitter) in CNS Therapeutic Class Anticonvulsant, vascular headache suppressants Pharmacologic Class None Nursing Considerations • May cause suicidal thoughts, agitation, dizziness, insomnia, hepatotoxicity, pancreatitis • Increases risk for bleeding with Warfarin • Use caution with MAOIs • Monitor liver function tests

Food is a huge part of most cultures. Yet, most people don't realize how the food you eat influences how you think, feel, and behave. What is Functional Medicine? Functional medicine is dedicated to getting to the root of the problem. Traditional medicine focuses on diagnosis and treatment, usually with pharmaceuticals.  Functional medicine focuses on supporting the body more naturally in order to reestablish balance. If you aren't feeling well, lack energy, etc., functional medicine can be used to dive deeper into the root cause of the imbalance in your body. This is a scientific but more natural approach. Both gut health and hormones are critical for our overall health, including our mental health. Gut health in relation to how the food you eat influences how you think The enteric nervous system is housed in our gut, which means the gut is home to a large portion of our nervous system. In addition,  the vagus nerve runs from the gut to the brain. This is how our body communicates either the flight or fight mechanism or rest and digest. The gut is regulated by the microbiome, bacteria in our gut, when the balance is off, the communication to our brain is skewed. And, when the microbiome is off, there is inflammation in the gut as well as in other areas of the body. When you are stressed, your gut health is not prioritized by the body. The gut suffers. Acid levels are altered and nutrients aren't absorbed properly. As a result, you can experience hormonal imbalances, inflammation, and a host of other things. This is why our gut health is so important. If you are struggling with mental health challenges, anxiety, brain fog, depression, or lack of focus, start with nutrition. What are you eating to nourish your body? What foods to avoid to lessen the impact on brain function Gluten - whether you have Celiac disease or not, you can have a gluten sensitivity because gluten causes inflammation in the gut lining which can cause inflammation in other areas of the brain, like brain fog. Gluten and other foods that cause inflammation in the gut affect the mucosa lining the gut. If it becomes too thin, things that are supposed to stay in the cut can cross over and get into the body. This creates an immune response because the body sees these things as foreign objects and thinks it needs to attack them to get rid of them. As a result, the inflammatory by-products of the immune response target other tissues like joints or skin, and you may experience reactions like pain or acne. Likewise, this reaction can result in inflammation in the brain and therefore you may experience brain fog. Corn and soy products are highly inflammatory and are often sprayed heavily with pesticides. In addition, there may be a cross-sensitivity with gluten. You won't necessarily have to avoid them forever, but eliminate them from your diet and reintroduce them when you are asymptomatic. Canola and vegetable oils Artificial colors and sweeteners Preservatives Refined carbohydrates like pasta, bread, pastries, and sugary foods can also cause inflammation. In addition, they may cause a glucose spike which will cause inflammation and affect mental health. Alcohol can mess with your neurotransmitters. Caffeine may not be metabolized as well in certain people. Think about eliminating these items 90% of the time and maybe allow yourself a treat 10% of the time. Where do you start to change your nutrition habits if concerned with how the food you eat influences how you think? Changing nutrition habits is very specific to each individual and their unique symptoms. If you have a lot of gut symptoms, it may be best to do a more comprehensive removal of food. However, if struggling with mental health challenges, but your gut seems okay, eliminate foods based on what's attainable to you. Throwing everything away or eliminating everything at once may not be feasible. If you are going to remove one item at a time, start with gluten. If you can't fully eliminate items, at least reduce them. Listen to episode 169 with Karolina Rzadkowolska. How to alter your alcohol consumption if you are concerned with how the food you eat influences how you think. If you drink every day, cut back to fewer days a week. If drinking multiple drinks every day, cut back to one drink per day. One glass of wine is not going to be the most terrible thing you do for yourself. However, it is important to consider when you drink. If you drink later in the evening, alcohol can influence your sleep because of an imbalance in GABA-glutamate and you'll wake up at around 2 AM and may experience hot flashes, and be thirsty. If you are drinking and you aren't sleeping, think about drinking earlier so that the alcohol metabolizes before you go to bed. Likewise, if you drink a lot, it will alter the food you crave and you'll lean towards less nutritious food in addition to increasing anxiety. One drink per night is probably fine for most people, but observe how it affects you. Let's talk about coffee Caffeine may increase anxiety. It is very specific to how you metabolize caffeine. Matcha green tea is a good alternative because it has caffeine but the caffeine is released steadily so you don't experience the peak and crash like with coffee. It also has L-Thiamine, which is a calming component. Therefore it can help you focus, but you can avoid the jitters or rise in anxiety. If you tolerate coffee, that's great. However, if you think caffeine might be a trigger for you, consider decreasing the intake or changing to Matcha tea. Another tip about coffee is to drink organic because it is often heavily sprayed with pesticides. Decaf coffee may be okay, but because of contamination with mold, Layne highly recommends going with an organic Matcha or green tea. Back to corn and its role in how the food you eat influences the way you think. In general, corn isn't the enemy, it's the processing. However, if you are gluten intolerant, you may cross-react to corn. If this is the case, eliminate it for a while until the gut heals and the mucosa lining builds back up, and then reintroduce it. Layne recommends Siete chips and tortillas because they are made with whole grains versus corn. Soy and its role in how the food you eat influences the way you think. The problem with soy is how it is sprayed and processed. Fermented organic soy is better for you. Do not eat inorganic soy. Tempe is an alternate form of soy, as well as tofu. The Dutch test is a comprehensive test for measuring hormones and determining your digestive pathways. Some people do really well with soy products but for other people, it may put them at higher risk for cancer. Are carbohydrates really the bad guy? Demonizing and avoiding carbs completely is not the best option because you need the micronutrients from fruits. It is the processed carbs that you want to be mindful of. Eat as many fruits and sweet potatoes as you want. To have a really well-balanced nutritious diet you need fruits and vegetables. Avoid white, wheat, and processed bread products. Bread products made from seeds and whole grains are better. But your body sees pasta and bread as sugars. But keep the fruits, potatoes, and vegetables. If going to have carbohydrates, eat the vegetables/fruits first, then the protein, and then the carbohydrates to avoid spikes in blood sugar. It is more about balance and moderation than eliminating completely. Will a gluten-free diet help you lose weight? A gluten-free diet may help you lose weight simply because you are eliminating foods that have been causing inflammation. It does eliminate a lot of the carbohydrates, so there may be weight loss but the goal of a gluten-free diet is to decrease inflammation, not necessarily to lose weight. What should you eat if concerned about how the food you eat influences how you think and you want to ensure a healthy body and brain? Whole foods are important as your main nutrition source. Eat as little processed food as possible. It is best to eat an array of colorful fruits and vegetables. Fruits and vegetables provide antioxidants to decrease inflammation and micronutrients your body needs to detox, balance hormones and feed the good gut bacteria. Good gut bacteria are critical for how our nervous system communicates with our brain. Wild blueberries are one of the top fruits for antioxidant benefits. Try to have 5 servings of fruits and vegetables a day. Healthy fats are also important for every cell in our body to have good integrity and for brain function. Salmon is Layne's favorite healthy fat but she suggested wild-caught salmon because it is the best form. You can also incorporate nuts and seeds, or even drizzle olive oil over your food. Aim for 5 servings of healthy fats a day. Avocados are also a healthy fat. Protein is also very important for brain health. Protein is made up of amino acids and they help our neurotransmitters work properly. Try to eat 30 grams of proteins in every meal. Eating 30 grams of protein for breakfast sets you up for success throughout the day and helps prevent the sugary cravings later in the day. Salmon is also a great source of protein, as well as chicken thighs. It is better to have bone-in chicken because of the nutrients and flavor. Eat a variety of meats, and red meat once or twice a week. A good healthy protein powder is also nice to have on hand because it is hard to get 30 grams of protein in every meal without a little bit of supplement. Nuzest is a clean lean protein powder option. Stress resiliency Stress never really goes away so we need to know how to handle it. Self-care is important for stress resilience. Eating healthy and stepping back from electronics and allowing yourself rest time. Magnesium is an important supplement for neurologic help. Layne recommends the glycinate and L Threonate forms of magnesium. These salts cross the blood-brain barrier. B Vitamins are also important for energy production and nervous system function. Nutrition is important and getting plenty of water is important. Our cells need water to function and energy is needed for our cells. Our parasympathetic nervous system is where we rest and digest. We want this to be our dominant nervous system. Ways to activate it include deep cleansing breaths, getting fresh air, and nature will help lower stress hormones, and focus on movement, exercise will help boost endorphins and help you feel better. In addition, if you have a caffeine intolerance, switch to Matcha or green tea to help you focus. The L Thianine will also help calm you. With anything that you are doing to make big changes, start small. Pick one thing that resonates most and be consistent with that. Set short attainable goals. The top 2 things to keep your mind and body healthy Nutrition - improve your nutrition, whole foods and fruits, and vegetables Regulate your nervous system - take 5 minutes twice a day for breathing, deep cleansing breaths. About Layne VanLieshout Layne is a board-certified Nurse Practitioner and founder of LV Wellness.  During her years in practice, she met many people who are not thriving or feeling well. This inspired her to become passionate about Functional Medicine. Layne trained at the School of Applied Functional Medicine, which equipped her to help others with their health on a much deeper level. She now creates a custom approach to address health struggles and wellness goals for her patients. As a Functional Medicine provider, she now helps people get to the REAL root cause of health issues and understand what needs to be done to prevent or mitigate dis-ease. She believes that's how she can truly help others heal. Download the free eBook on Alleviating Anxiety by Developing Health Habits for a Healthy Mind.  Learn more about and connect with Layne: Layen's Vanlieshout's website  Find Layne on Instagram   

It was a gorgeous summer Saturday morning - and this "Risin' " session reflected that - so, laid back goodness all the way on the soulful, deep and broken - do enjoy!!Track-listing:Hyenah, Pablo Fierro & Lazarusman - The BalanceDany Cohiba - Church Soul Preacher (Original Mix)Kato Change, Winyo & SURAJ - Suna (Da Africa Deep Afrikan Remix)Kiko Navarro feat. Dana Mamam - Ogun In Ta Ete We (She Is Calling) (Original Mix)Coco feat. Gil Bokobza - Sometimes I LieImaani - Found My Light (Atjazz Remix)Tortured Soul - Your Body Doesn't Lie (Atjazz Love Soul Remix)Sean Smith & Lafayette Parker - It's True (Original Vocal)N'dinga Gaba feat. Sahffi - Summer Breeze (Fka Mash Re-glitch)The Disclosure Project - Fortean QuackKen@Work - Vibes Alive (Original Mix)Lanu feat. Abby Joyce & Simon Grey - RiseLanu - DisinformationDoob – If (U-key Remix)Hajime Yoshizawa – I Am With You (Main Mix)Bobby Caldwell – What You Won't Do For Love (Eddy Meets Yannah Remix)NATE08 - Sunrise SunfallNext Door But One - Where Would I Be (Extended)Artwork Sounds feat. Brian Temba - Lift Him UpArtwork Sounds, CocoSA & Russell Zuma - Woza MoyaEcho Deep & MoreSoul - If We Try (Original Mix)…and here's the download link:https://www.sendspace.com/file/f87mzd…hope you enjoy – as always, thanks to all who locked on…https://pressureradio.com

Huberman Lab Podcast Notes Key Takeaways Hallmark feature of obsessive-compulsive disorder: intrusive obsessions, meaning the person doesn't want to have themEvery time one engages in a compulsion (action) related to the obsession (thought), the obsession becomes stronger in a powerful and debilitating loopSuppressing anxiety in the wrong direction to take if trying to relieve or eliminate OCDThe goal of cognitive behavior therapy in the context of OCD is to uncover the underlying fear driving the OCD – then take the patient to the highest anxiety point to disrupt the neural circuit between the processing and action parts of the brain to tolerate the anxiety and avoid the compulsionThe most helpful treatment routes are either cognitive behavioral therapy alone or adding cognitive behavioral therapy to an existing SSRI protocol (treatments take 10-12 weeks for full effect)Obsessive-compulsive personality disorder: delayed gratification people want or enjoy because it allows them to function better and or in line with how they would like to present themselvesSuperstitions: a belief that we are affecting the probability of an outcome when we truly know in our rational minds that there is no real relationship to the outcomeRead the full notes @ podcastnotes.orgIn this episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD)—a prevalent and debilitating condition. I also discuss the efficacy and mechanisms behind OCD treatments—both behavioral and pharmacologic as well as holistic and combination treatments and new emerging treatments, including directed brain stimulation. I explain the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I review cognitive-behavioral therapies like exposure therapy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of each approach and what science says about how to combine and sequence treatments. I describe an often effective approach for treating OCD where clinicians use cognitive behavioral therapy (CBT) to deliberately bring patients into states of high anxiety while encouraging them to suppress compulsive actions in order to help them learn to overcome repetitious thought/action cycles. This episode should interest anyone with OCD, anyone who knows someone with OCD or OCPD, and more generally, those interested in how the brain works to control thoughts and actions, whether those thoughts are intrusive or not. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Obsessive-Compulsive Disorder (OCD) (00:03:01) Momentous Supplements, AG1 (Athletic Greens), Thesis, Eight Sleep (00:08:28) What is OCD and Obsessive-Compulsive Personality Disorder? (00:11:18) OCD: Major Incidence & Severity (00:15:10) Categories of OCD (00:21:33) Anxiety: Linking Obsessions & Compulsions (00:27:33) OCD & Familial Heredity (00:29:10) Biological Mechanisms of OCD, Cortico-Striatal-Thalamic Loops (00:39:36) Cortico-Striatal-Thalamic Loop & OCD (00:46:39) Clinical OCD Diagnosis, Y-BOCS Index (00:51:38) OCD & Fear, Cognitive Behavioral Therapy (CBT) & Exposure Therapy (01:01:56) Unique Characteristics of CBT/Exposure Therapy in OCD Treatment (01:10:18) CBT/Exposure Therapy & Selective Serotonin Reuptake Inhibitors (SSRIs) (01:22:30) Considerations with SSRIs & Prescription Drug Treatments (01:25:17) Serotonin & Cognitive Flexibility, Psilocybin Studies (01:31:50) Neuroleptics & Neuromodulators (01:36:09) OCD & Cannabis, THC & CBD (01:39:29) Ketamine Treatment (01:41:43) Transcranial Magnetic Stimulation (TMS) (01:46:22) Cannabis CBD & Focus (01:47:50) Thoughts Are Not Actions (01:51:27) Hormones, Cortisol, DHEA, Testosterone & GABA (02:00:55) Holistic Treatments: Mindfulness Meditation & OCD (02:03:28) Nutraceuticals & Supplements: Myo-Inositol, Glycine (02:09:45) OCD vs. Obsessive-Compulsive Personality Disorder (02:20:53) Superstitions, Compulsions & Obsessions (02:31:00) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Do you wish you could experience the same effects of alcohol, but without the hangover?   In this episode of the Align podcast, Cameron George and I chat about what Kava is exactly, its main benefits, and how it impacts your nervous system. We also explore what senescent cells are and how they relate to the psychedelic experience of psychotropic medicines. Lastly, we cover how Kava can help reset your sympathetic system.    Cameron is a researcher, writer, entrepreneur and the founder of TRU KAVA, a company that is striving to set the industry standard for quality, safety and education around kava within the mass market. TRU KAVA is focused on developing scalable user-friendly products that deliver the full therapeutic action of the traditional kava drink, which is the only form has been highly prized in south pacific islands for over 3000 years.   What we discuss:   03:16: What does the psychedelic experience like from a neuro-chemical perspective? 09:27: What does it mean to experience a re-sensitization to reality? 14:23: What is a senescent cell? 31:07: What is Kava? 52:02: How does Kava impact the nervous system? 01:02:48: How does being in a constant sympathetic state affect your libido? 01:13:42: What other substances can restore the GABA system? 01:30:45: How did Cameron beat his addiction 01:51:40: What is a tonic? 01:53:35: What is the recommended dosage of Kava? 02:02:52: What “stacks” does Cameron recommend?     To learn more about Cameron:   Website: trukava.com  Instagram: @trukava     Related links:   The revised version of the Align Method book is now available with 22 brand-new exercises! Order here: alignpodcast.com/alignbook   alignpodcast.com/alignmethod for a special discount   alignpodcast.com/community to join our community   magbreakthrough.com/alignpodcast and use ALIGN10 during checkout to save 10%   gettrukava.com/discount/ALIGN15 and use code ALIGN15 to save 15%   branchbasics.com/alignpodcast and use code ALIGN to save 15% on all Starter Kits (except the Trial Kit)

In this episode, Dr. Doni Wilson, host of How Humans Heal, describes what it takes to find the highest quality and most efficacious supplements. Dr. Doni breaks through the sales and marketing to show you behind the scenes of DoctorDoni.com and Nature Empowered Nutritionals.     Ultimately, it's about giving your body the nutrients, herbs and other support from nature to help you recover from depletions and disruptions caused by stress.     We are stressed as humans. Stress decreases our ability to digest food, causes leaky gut and imbalanced gut bacteria. It also makes us susceptible to infections, including viral infections, as well as low serotonin and GABA. These can be addressed clinically with nutrients, herbs, homeopathic remedies and peptides. Hormone imbalances can also be addressed.     -    It is essential to use high quality supplements at effective doses. This is not something you have to figure out on your own. That would require hours and hours (years even) of research and trials. And they are not supplements you will find at the regular store.    That's why I do what I do. Using my training, with a doctorate degree from Bastyr University, which is not a weekend course or online training. It was a 5-year, post-graduate, in-person degree program and residency which I completed 22 years ago.      Nor should you need to figure out what to take together or apart, or potential interactions. That's all part of my training and continuing education. It's also what I teach naturopathic students who train with me.     In my case, I've chosen to run an online store where I can make these high-quality supplements available to you and my patients. I don't want my suggestions or your access to be limited to certain companies determined by a distributor. I want to make it possible for you to get the products that are most effective clinically. I also want to make sure you know you can access those supplements from a trusted source. To do that, I have to research and maintain a store for you to use.     -   The store at DoctorDoni.com was recently updated to make it easier for you to use and to find what you need. We carry over 700 products from companies I have vetted and products I've tested on myself and used clinically.     I also decided to create my own supplement company – Nature Empowered Nutritionals – so that I can offer you the supplements I recommend based on my Stress Recovery Protocol. Other practitioners who create a supplement choose based on what is easiest to formulate. I chose based on wanting you to have exactly the ingredients that I find to be most effective.     I know it can seem too good to be true. When we are dealing with chronic illness and feeling lost in the medical system, it can be hard to believe that solutions exist. And I'm not saying this is the right fit for everyone. It is always important to know your body, your preferences, your allergies and sensitivities, and your medical history.    -    I absolutely believe customizing your supplement protocol based on your individual case is imperative. That's why I offer group online programs and one-on-one consultations with me so that you can get access to the information you need, and testing to understand the imbalances in your body, so that you can pinpoint exactly what your body needs.     It is not about taking a bunch of random supplements. It is about understanding human physiology, biochemistry, clinical nutrition, herbalism, homeopathy, and research about how to support the body to heal.     For example, if you have elevated cortisol levels, there are specific nutrients and herbs to help bring it back down to optimal. If you have low serotonin (which we can also measure), then we know 5HTP, as a precursor nutrient, will give your body what it needs to make more. How much and when to take it, and what if you are on medications? Then you need to meet with me one-on-one so I can guide you.     -    I feel it is my role and purpose to provide information about the protocol I've identified in the process of healing by body and helping thousands of patients. That's what my team helps me to create at DoctorDoni.com where we have lots of free resources in addition to learning opportunities and access to the highest quality and effective supplements.     Thank you so much for your feedback, questions, and trust.     Dr. Doni   -    To read more about these concepts, be sure to get a hold of my new book, Master Your Stress, Reset Your Health.   https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576     -   Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Books and Resources:    Order My New Book: https://DoctorDoni.com/msrh      https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576   Stress Warrior Book (FREE)  HTTPS://DOCTORDONI.COM/STRESSWARRIOR      Stress Warrior Stress Resiliency Facebook Group (FREE)  HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR     7-day Stress Reset (FREE)  HTTPS://DOCTORDONI.COM/STRESS-RESET     HPV & Cervical Dysplasia Guide (FREE)  HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/     -   Personalized Solutions:    If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH     To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.

In this episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD)—a prevalent and debilitating condition. I also discuss the efficacy and mechanisms behind OCD treatments—both behavioral and pharmacologic as well as holistic and combination treatments and new emerging treatments, including directed brain stimulation. I explain the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I review cognitive-behavioral therapies like exposure therapy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of each approach and what science says about how to combine and sequence treatments. I describe an often effective approach for treating OCD where clinicians use cognitive behavioral therapy (CBT) to deliberately bring patients into states of high anxiety while encouraging them to suppress compulsive actions in order to help them learn to overcome repetitious thought/action cycles. This episode should interest anyone with OCD, anyone who knows someone with OCD or OCPD, and more generally, those interested in how the brain works to control thoughts and actions, whether those thoughts are intrusive or not. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Obsessive-Compulsive Disorder (OCD) (00:03:01) Momentous Supplements, AG1 (Athletic Greens), Thesis, Eight Sleep (00:08:28) What is OCD and Obsessive-Compulsive Personality Disorder? (00:11:18) OCD: Major Incidence & Severity (00:15:10) Categories of OCD (00:21:33) Anxiety: Linking Obsessions & Compulsions (00:27:33) OCD & Familial Heredity (00:29:10) Biological Mechanisms of OCD, Cortico-Striatal-Thalamic Loops (00:39:36) Cortico-Striatal-Thalamic Loop & OCD (00:46:39) Clinical OCD Diagnosis, Y-BOCS Index (00:51:38) OCD & Fear, Cognitive Behavioral Therapy (CBT) & Exposure Therapy (01:01:56) Unique Characteristics of CBT/Exposure Therapy in OCD Treatment (01:10:18) CBT/Exposure Therapy & Selective Serotonin Reuptake Inhibitors (SSRIs) (01:22:30) Considerations with SSRIs & Prescription Drug Treatments (01:25:17) Serotonin & Cognitive Flexibility, Psilocybin Studies (01:31:50) Neuroleptics & Neuromodulators (01:36:09) OCD & Cannabis, THC & CBD (01:39:29) Ketamine Treatment (01:41:43) Transcranial Magnetic Stimulation (TMS) (01:46:22) Cannabis CBD & Focus (01:47:50) Thoughts Are Not Actions (01:51:27) Hormones, Cortisol, DHEA, Testosterone & GABA (02:00:55) Holistic Treatments: Mindfulness Meditation & OCD (02:03:28) Nutraceuticals & Supplements: Myo-Inositol, Glycine (02:09:45) OCD vs. Obsessive-Compulsive Personality Disorder (02:20:53) Superstitions, Compulsions & Obsessions (02:31:00) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News topic du jour:

GABA is an important neurotransmitter you don't hear about much. Learning of my own low GABA symptoms changed my life – I should say saved my life Is GABA Similar to Serotonin? GABA is Gamma-Aminobutyric Acid. Along with Serotonin, these neurotransmitters provide the “brakes” to overstimulated nerve impulses. Keeping the brain relaxed but on purpose is their job. Dopamine, Adrenaline, Acetylcholine, and anxiety are emotional, hormonal and neurological stimulants. They set off a chain reaction of stress, causing interference all over the body. When our brakes are inadequate to the task, we suffer from imbalanced neurotransmitters and hormones. more information...

Here are the notes for episode #378 of Well-Fed Women. Be sure to check back every Tuesday for a new episode, and head over to Apple Podcasts or Stitcher to subscribe!To leave a review for the podcast (HORRAY!), go to: https://coconutsandkettlebells.com/reviewIn this episode, Noelle and Stefani discuss current thoughts on food freedom, weight gain, and judging others.Got a question you'd like us to answer? Email us at wellfedwomen@gmail.com.10% of the funds we receive from our sponsors is donated directly to our partner charity, Thistle Farms, a place where women survivors of abuse, addiction, trafficking and prostitution receive help and support through residential programs, therapy, education, and employment opportunities. Because we get paid per download, you are actively supporting Thistle Farms by downloading our podcast each week.Topics![13:55] Current Thoughts on Food Freedom, Weight Gain, and Judging OthersLinks!Noelle's website: https://coconutsandkettlebells.comStefani's website: http://healthtoempower.comBuy our book Coconuts and KettlebellsOrganifiMagbreakthrough.com/wellfedBeautycounterOrganifiSupport your body, energy, immunity, and stress with Organifi.Organifi takes pride in offering the best tasting superfood products on the market at a price that works out to less than $3 a day.You can experience Organifi's high-quality superfoods without breaking the bank.Go to www.organifi.com/wellfed and use code wellfed for 20% off your order.BiOptimzerDid you know that over 80% of the population is deficient in Magnesium and it is the #1 mineral you need for stress, fatigue and sleep issues?Magnesium increases GABA, which encourages relaxation on a cellular level and is critical for sleep. And because stress depletes magnesium, this also means magnesium is needed to support your body's stress response. Magnesium is THE single most studied mineral in existence. It powers over 600 critical reactions in our bodies.Most magnesium supplements fail because they are synthetic and are NOT FULL SPECTRUM. When you get all 7 critical forms of magnesium, you are supporting every function in your body that requires magnesium, and you can reverse magnesium deficiency and continue to support your body during times of stress and especially during pregnancy with one supplement.That's why I'm so excited about Magnesium Breakthrough. I recommend Magnesium Breakthrough because it combines all 7 essential forms of magnesium into one convenient supplement. Today you can get 10% OFF with our coupon code.Visit www.magbreakthrough.com/wellfed and enter code WELLFED10