Podcasts about Gaba

Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRG and save up to 39% off your Mitopure® Gummies. → Puori | Go to https://puori.com/DRG and use the code DRG at checkout to get 32% off your first Puori Creatine+ subscription order. → My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description Your body isn't broken. It's stuck — and there's a very specific reason why. 94% of U.S. adults have some degree of mitochondrial dysfunction. That means the majority of people walking around right now can't make energy efficiently — and they're using caffeine, stimulants, and willpower to paper over it. Dr. Scott Sherr has spent over a decade figuring out why, and more importantly, how to actually fix it. Board-certified in internal medicine and one of the leading voices in health optimization medicine, Dr. Sherr introduces one of the most important concepts Dr. G has heard in a long time: the sympathetic spiral of doom — the feedback loop between chronic stress and mitochondrial breakdown that keeps you wired, exhausted, and unable to heal no matter what you try. In this episode, you'll discover: • Why more caffeine, more supplements, and more biohacks are making the spiral worse — and what to do instead • The GABA system: why depression and anxiety may have nothing to do with serotonin, and everything to do with your brain's brakes failing • The leaky gut → leaky brain connection most doctors have never heard of • How methylene blue works at the mitochondrial level — and why dose and source matter more than you think • What it actually means to optimize your health back to the resilience of your 20s — at any age If you've seen 10 doctors, tried every supplement, and still feel like you can't recover — this episode is the missing piece. Find Dr Sherr: Website: https://www.hyperbaricmedicalsolutions.com/integrative-hbot/scott-sherr Instagram: https://www.instagram.com/drscottsherr  Timestamps: 0:00 - Introduction 0:35 - Rapid Fire Q&A: Caffeine, Methylene Blue & Mitochondria 2:05 - Dr. Scott's Background: From Hospitalist to Health Optimization 8:50 - What Is Health Optimization Medicine? (Ages 21–30 Blueprint) 16:20 - The Sympathetic Spiral of Doom Explained 24:30 - Signs You're Stuck in Fight-or-Flight Mode 33:00 - The GABA System: Why Supplements Don't Cross the Blood-Brain Barrier 43:57 - Methylene Blue Deep Dive: How It Works & Who It's For 51:17 - How to Shop for Methylene Blue (Quality & Dosing Guide) 56:29 - Dr. Scott's Personal Routine for Mitochondria & Nervous System Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you successful but secretly running on empty? Most high-performing men are chasing success while feeling isolated, overworked, and physically deteriorating—and they don't even realize it. In this masterclass, I sit down with Dr. Scott Sherr, a board-certified internal medicine physician and health optimization expert, to dismantle the "Success Lie" that is leading men to burnout. We dive into the biological "Warrior to Wizard" transition and how to optimize your cellular architecture so you can win at work without losing at home. Troscriptions Website: https://troscriptions.com/modernman  STOP GUESSING. START LEADING. Take the "Where Did My Time Go?" Audit now to identify your time leaks and reclaim 10-20 hours of your week: https://themodernmanpodcast.com/wheredidmytimego  What You Will Learn In This Masterclass: The Sympathetic Spiral of Doom: Why staying in "fight or flight" mode leads to mitochondrial suicide and chronic disease. Warrior vs. Wizard: How the biological definition of strength must change as you lead a business and family. The "Normal" Trap: Why the standard medical definition of "normal" is actually a dangerous baseline for a high-performing man. Cognitive Edge: The truth about Methylene Blue and low-dose nootropics for bypassing brain fog and entering flow state. GABA vs. Serotonin: Why your "anxiety" is likely a braking-system issue, not a happiness issue. CHAPTERS 00:00 – The "Normal = Deteriorating" Trap  02:11 – The Warrior to Wizard Transition (Parenting & Control) 05:58 – Signs Your Nervous System is Crashing  08:56 – Why High-Performance Men Shouldn't Want to be "Normal"  11:17 – Mitochondria: The Engine of Executive Focus  14:27 – The Truth About Trauma Center "Health"  17:22 – The Sympathetic Spiral of Doom Explained  22:31 – How ATP Deficiency Destroys Decision Making  28:46 – Methylene Blue: A Battery Charger for the Brain  40:31 – The GABA Solution for Calm in the Storm  45:26 – Breaking the Spiral: Actionable Routines  50:23 – Identity Beyond the Title (Fatherhood & Legacy) ABOUT DR. SCOTT SHERR: Dr. Scott Sherr is a board-certified internal medicine physician specializing in Health Optimization Medicine (HOMe). He is the COO of Troscriptions and a lead faculty member of the HOMe-HOPe nonprofit, where he translates complex biochemical mechanics into actionable protocols for high-stakes performance. Sherr's Links: Website: https://drscottsherr.com/ https://homehope.org/ Instagram: drscottsherr   Free eBook Here: Mastering Self-Development: Strategies of the New Masculine: https://rebrand.ly/m2ebook ⚔️JOIN THE NOBLE KNIGHTS MASTERMIND⚔️ https://themodernmanpodcast.com/thenobleknights 

In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women's health: progesterone. Progesterone is not “good” or “bad.” It's contextual. In today's world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like “progesterone fixes anxiety” or “progesterone causes breast cancer.” The truth? It depends on your body, your stress levels, your liver health, your inflammation, your delivery method, and whether you're using bioidentical progesterone or synthetic progestins.   Citations: 1. Oral Progesterone → First-Pass Metabolism & Allopregnanolone Claim: Oral micronized progesterone undergoes significant hepatic first-pass metabolism, increasing neuroactive metabolites (especially allopregnanolone), which positively modulate GABA-A receptors and produce sedative/anxiolytic effects. Core Evidence: Simon et al., 1993; de Lignières et al., 1995; Freeman et al., 1990 — Oral progesterone produces measurable neuroactive metabolites. Paul & Purdy, 1992; Rupprecht et al., 2001 — Allopregnanolone enhances GABA-A receptor activity. Supports: Sedation variability by route • Neurosteroid generation • GABA-A modulation 2. Sulfation vs 5α-Reduction → Opposing Neurologic Effects Claim: Progesterone metabolites can produce calming (5α-reduced) or excitatory (sulfated) neurologic effects depending on enzyme routing. Core Evidence: Majewska et al., 1990 — Pregnenolone sulfate negatively modulates GABA-A. Wu et al., 1991 — Sulfated neurosteroids enhance NMDA signaling. Schumacher et al., 2007; Reddy, 2010 — Pathway reviews of sulfation vs 5α-reduction. Supports: Reverse responding hypothesis • Divergent neurologic experiences • Enzyme-dependent effects 3. Stress & Enzyme Modulation Claim: Chronic stress alters HPA axis tone and hepatic enzyme expression, influencing steroid metabolism balance. Core Evidence: McEwen, 1998 — Allostatic load model. Charmandari et al., 2005 — Cortisol's systemic regulatory effects. Zanger & Schwab, 2013; Gibson & Skett, 2001 — Stress alters cytochrome P450 expression. Supports: Stress-biased metabolism • Context-dependent hormone response 4. Breast Tissue Signaling & Context Claim: Progesterone influences mammary differentiation and interacts with estrogen signaling in context-dependent ways. Core Evidence: Brisken & O'Malley, 2010 — Progesterone receptor biology in breast tissue. Beleut et al., 2010 — RANKL mediates progesterone-driven proliferation. Hofseth et al., 1999 — PR-ER signaling interaction. Stanczyk & Bhavnani, 2014 — Natural vs synthetic differences in breast effects. Supports: Lobuloalveolar differentiation • RANKL pathway • Context-dependent proliferation 5. Synthetic Progestins vs Bioidentical Progesterone Claim: Synthetic progestins differ structurally and bind off-target receptors, producing distinct tissue effects. Core Evidence: Stanczyk et al., 2013 — Receptor binding differences. Sitruk-Ware, 2004 — Biologic comparisons. Chlebowski et al., 2003 (WHI) — Breast cancer signal with CEE + MPA. Supports: Structural divergence • Receptor-level differences • WHI clarification 6. Route of Delivery Differences Claim: Oral, vaginal, transdermal, and sublingual progesterone produce distinct pharmacokinetic profiles and tissue targeting. Core Evidence: Simon, 1995 — Oral vs vaginal PK comparison. Cicinelli et al., 2000 — “First uterine pass effect.” Wren et al., 2003 — Route-dependent systemic levels. Supports: Uterine targeting • Neurosteroid variability • Sedation differences 7. Progesterone, PMS & Migraine Claim: Neurosteroid fluctuations influence GABAergic tone and may contribute to PMS and migraine susceptibility. Core Evidence: Backstrom et al., 2011 — Allopregnanolone fluctuations in PMS. Reddy & Rogawski, 2002 — Neurosteroids and seizure threshold. Martin & Behbehani, 2001 — Hormonal fluctuations and migraine. Supports: Luteal neurosteroid shifts • GABA instability • Migraine association   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

00:00 Why Denervation Can Cause Spasticity (Key Neurology Principle) 01:09 Podcast Intro + Quick Housekeeping (Dogs, Door, and Vigilance) 02:30 The "Impossible" Case: Meige Syndrome Explained 03:42 Vagus Nerve Clues & First-Day FSM Results 07:05 Building the Brain Protocol: Pons Neurotransmitters + Botox Context 08:43 Day Two Strategy: Quiet Basal Ganglia & Cerebellum, Support the Pons 11:59 How She Decides What to Change Mid-Treatment (Intuition + Feedback) 12:44 Substrate Matters: GABA/5-HTP Support When Forcing Secretions 18:18 Emotional Frequencies + Speech Pathways (Why Words Triggered Eye Closure) 23:47 Looking It Up Is the Skill: First Principles, Collaboration, and Finding FSM 28:24 CustomCare as Ongoing Management + "FSM First Aid" Protocols 32:11 Root Cause Timeline: Stress Triggers, Misdiagnosis, and Why Medicine Gets Stuck 34:55 Quick Fixes vs Root Cause: Botox, Hyperacusis & Vagus Nerve Clues 35:59 Why the Pons Keeps Showing Up: Patterns, TIAs & Frequency Results 37:41 Rehab Courses Mindset: Assess, Measure, and Prove Progress 39:16 Setting Realistic Expectations: ROM Gains, Pain, and the "Titanium Knee" Reality 41:58 Metrics Beyond Numbers: Confidence, Mood, and the Emotional Work of Healing 44:46 Keep Learning + Resources: Advanced Courses & "Molecules of Behavior" Lectures 46:26 Case Q&A: Spontaneous Pneumothorax—Pleura Scarring, Hypermobility & Breath Coaching 52:02 Hypermobility on Your Radar: Memory Complaints, Mini Mental Status Checks & Re-testing 55:56 Trauma Cases & Documentation: Auto Accidents, Forensics, and Imaging/PT Referrals 58:52 Wrap-Up: Daughter Update, Advanced Signup, Foundation Mission + Podcast Disclaimer In this episode of the Frequency Specific Microcurrent (FSM) podcast, Dr. Carol and Kim Pittis discuss approaching complex, unfamiliar cases by returning to first principles, researching in real time, and collaborating with patients. Dr. Carol shares a case of Meige (MEIGE) syndrome involving severe facial muscle spasticity and involuntary eye closure triggered by speaking, plus light sensitivity, absent gag reflex (partially restored after chiropractic care), elevated shoulders, and a history of extreme stress and childhood abuse. After identifying likely involvement of cranial nerve VII and structures associated with the pons, vagus, basal ganglia, cerebellum, and medulla, they describe an evolving FSM strategy: running protocols such as concussion and vagus/vagal tone, pons repair, increasing secretions in the pons, and "quieting" the basal ganglia and cerebellum (including noting 40/988 for quieting basal ganglia). They discuss searching neurotransmitters of the pons (acetylcholine, GABA, serotonin, norepinephrine), emphasizing inhibitory support via GABA and serotonin, supplementing with chewable GABA and later ordering 5-HTP, and the concept that using "increase secretions" can require providing precursors/substrate to avoid depletion. They also add emotional frequencies for fear/terror and note functional changes across two days, including relaxed facial muscles and improved blinking and speech-related eye control, then send the patient home with a five-hour nighttime program and a loaner device, with follow-up planned. The conversation also covers patient education, expectations and management with CustomCare devices, tracking outcomes with metrics like range of motion and confidence.

Rk Fusion - Time Flight (The James L'estraunge Orchestra Remix) Soul Renegades - Speak To Me (James L'Estraunge Orchestra Remix) Piers Kirwan, Javonntte - On & On Kyoto Jazz Massive, Echoes Of A New Dawn Orchestra - Impulsive Procession Lovetempo - But I Do (Crackazat Extended Remix) Terrence Parker - Beyond (Deeper Love) (TP's Vocal Vibe Mix) Klevakeys — Journey to the Sun (Klevakeys Deep Mix) AC Soul Symphony - K-Jee (Joey Negro Philly World Mix) Deep Soul Syndicate - My Heart feat Stephanie Cooke (Tribe Vocal) Robert Matos - Midnight Jazz Journey (Coflo's Digital Only Mix) Deep Roger, Marc Evans - Make Love Great Again (Original Mix) Eddie Fowlkes, Dames Brown - Do It (Extended Mix) Doug Gomez - Mother Nature (Original Mix) Coflo x CEE - Loves Masquerade (Vick Lavenders Time Traveler Remix) Brutha Basil, N'dinga Gaba - Fly High (N'Dinga's Soulful High Vocal Mix) Brian Alexander Morgan - Give It 2 Ya (The BAM & Spen House Projex Remix) Blaze - We Are One (Coflo Remix) Jaidene Veda, N'dinga Gaba feat. Josh Milan - Beautiful(Doug Gomez Merecumbe Soul Remix) Thommy Davis, Randy Roberts, Neal Conway-Darlin' Darlin' Baby (Sweet and Tender Love) Deepo, Pietro Nicosia - Clothes Off (Original Mix)

It's cold in the studio again, but TJ is hot especially coming back Monday from Valentines Day weekend with Mrs. Trout. Then TJ complains about Tax season, and why they can't just make it simple ha! The wind is coming so beware, and lastly Gaba talks about bills that passed and failed. All this and more on News Radio KKOBSee omnystudio.com/listener for privacy information.

Rk Fusion - Time Flight (The James L'estraunge Orchestra Remix) Soul Renegades - Speak To Me (James L'Estraunge Orchestra Remix) Piers Kirwan, Javonntte - On & On Kyoto Jazz Massive, Echoes Of A New Dawn Orchestra - Impulsive Procession Lovetempo - But I Do (Crackazat Extended Remix) Terrence Parker - Beyond (Deeper Love) (TP's Vocal Vibe Mix) Klevakeys — Journey to the Sun (Klevakeys Deep Mix) AC Soul Symphony - K-Jee (Joey Negro Philly World Mix) Deep Soul Syndicate - My Heart feat Stephanie Cooke (Tribe Vocal) Robert Matos - Midnight Jazz Journey (Coflo's Digital Only Mix) Deep Roger, Marc Evans - Make Love Great Again (Original Mix) Eddie Fowlkes, Dames Brown - Do It (Extended Mix) Doug Gomez - Mother Nature (Original Mix) Coflo x CEE - Loves Masquerade (Vick Lavenders Time Traveler Remix) Brutha Basil, N'dinga Gaba - Fly High (N'Dinga's Soulful High Vocal Mix) Brian Alexander Morgan - Give It 2 Ya (The BAM & Spen House Projex Remix) Blaze - We Are One (Coflo Remix) Jaidene Veda, N'dinga Gaba feat. Josh Milan - Beautiful(Doug Gomez Merecumbe Soul Remix) Thommy Davis, Randy Roberts, Neal Conway-Darlin' Darlin' Baby (Sweet and Tender Love) Deepo, Pietro Nicosia - Clothes Off (Original Mix)

The story we've been told about cannabis—safe, simple, and mostly benign—doesn't match what we're seeing at the bedside. Two ER-turned-addiction doctors pull back the curtain on how high-potency products can quietly undercut psychiatric meds, complicate procedural sedation, and nudge recovery off course even when everything else looks better. This isn't a panic piece; it's a practical guide to staying safer and getting more from treatment.We start with psychiatry and a pattern that's easy to miss: chronic cannabis use can upregulate ABC transporters along the gut, liver, and blood-brain barrier, pushing certain antipsychotics and mood meds out of cells faster and blunting their effect. What looks like “noncompliance” may be pharmacology. We talk through which agents lean on these transporters, which alternatives may perform better, and how to have a stigma-free conversation that protects trust while fixing the plan.Then we roll into the procedure room. Heavy cannabis use can decrease sensitivity to propofol and other sedatives by altering GABA activity and endocannabinoid tone, often requiring higher doses and tighter monitoring. Add a lesser-known risk—post-propofol hypersalivation in frequent users—and disclosure becomes a safety tool. We share exactly what to tell anesthesia, what clinicians can prepare for, and how to keep airways protected without surprises.Finally, we examine the “Cali sober” idea through data, not dogma. Large cohort studies link cannabis use to higher rates of alcohol recurrence and new substance use disorders over time, especially with potent concentrates. We cover why potency and pattern matter, how cannabis can dampen the gains of CBT, MI, and contingency management, and what a realistic harm reduction path looks like when abstinence isn't the first stop. Throughout, we keep language careful—reported use, not admitted; return to use, not relapse—because words shape trust.If you care for patients, care about someone in recovery, or care about your own health, this conversation offers a clear framework: ask better questions, match meds to biology, and align goals to protect progress. Subscribe, share with a colleague or friend, and leave a quick rating to help others find the show. What did you learn that changes your practice—or your plan—today?Link to State by State Alternatives to California Sober: https://www.mcsweeneys.net/articles/local-alternatives-to-california-soberTo contact Dr. Grover: ammadeeasy@fastmail.com

In this episode of Talking Sleep, host Dr. Seema Khosla welcomes Dr. Mark Boulos, Dr. Khullar, and Dr. Mak for an in‑depth discussion on a topic that has challenged clinicians for decades: Are hypnotics safe for patients with untreated obstructive sleep apnea (OSA)? As new therapeutic options emerge and our understanding of comorbid insomnia and sleep apnea (COMISA) evolves, clinicians are increasingly confronted with nuanced decisions about when—and whether—to use hypnotic medications. The guests unpack the latest evidence and share insights from recent studies, including research evaluating dual orexin receptor antagonists (DORAs) such as lemborexant in individuals with sleep apnea. The conversation begins with a review of hypnotic medication classes and explores which agents may be safer in untreated OSA, and which still raise concerns. The panel discusses a recent lemborexant study, its design, population characteristics (including BMI and OSA severity considerations), and whether industry sponsorship played a role. They clarify that while the study did not focus specifically on COMISA, it sheds light on how DORAs perform in people with sleep apnea—particularly in terms of respiratory metrics. Returning from the break, the experts tackle the practical clinical dilemma of treatment sequencing in COMISA: Should clinicians begin with cognitive behavioral therapy for insomnia (CBT‑I), initiate PAP therapy, or consider medications first? They walk through what is known about how different hypnotic classes—including z‑drugs, GABAergic agents, trazodone, and DORAs—affect respiratory drive and sleep architecture. The discussion extends to special circumstances such as REM‑related OSA, where increased REM sleep induced by certain medications may have unique implications. The episode also considers broader emerging questions: Do DORAs improve apnea–hypopnea index (AHI) even without PAP? Can hypnotics be used strategically to improve sleep continuity without worsening respiratory parameters? And will future insomnia care rely on identifying phenotypes that respond differently to GABA‑based medications or wakefulness‑impairment targets? Throughout the conversation, the guests emphasize evidence-based takeaways, including the central finding that DORAs do not appear to worsen OSA‑related metrics, offering reassurance for clinicians navigating complex COMISA treatment plans. Whether you regularly see patients with comorbid insomnia and untreated sleep apnea or simply want clarity on the evolving role of hypnotics in this population, this episode offers practical, research-grounded guidance for clinical decisionmaking. Join us for this important discussion on how hypnotics can be used safely and thoughtfully in patients with untreated OSA.

Join EEG legend Jay Gunkelman (500,000+ brain scans read) and host Pete Jansons for a thorough exploration of Sensorimotor Rhythm (SMR) — the calming, stabilizing brainwave discovered by Barry Sterman.From cats trained on SMR that resisted toxic rocket fuel seizures (NASA origins) to modern uses in ADHD, epilepsy, insomnia, fibromyalgia, and arousal regulation — this episode breaks down the science, circuits, and clinical realities.✅ Key Topics Covered:Barry Sterman's breakthrough: SMR-trained cats survived rocket fuel doses that caused vomiting, panting, salivating, and seizures in controls (ruined the dose-response curve)Brain circuitry: Thalamus (ventroposterior lateral nucleus) + reticular nucleus (acetylcholine bursts) → sensory-motor cortex feedback → red nucleus quieting → muscle spindle relaxationSMR as daytime "sleep spindle": Stabilizes red nucleus (Parkinsonism target), cuts sympathetic drive, deeper muscle relaxation, reduces sensory feedback to thalamusBenefits: Epilepsy stabilization, fibromyalgia (quiets sympathetic input to red nucleus), ADHD clusters (excess theta/alpha, beta compensation), arousal-performance curve centeringRisks: Overtraining SMR drops arousal too far → underarousal/grogginess/rebound giddiness (like kids pre-bedtime); counter with anterior beta (17Hz functional beta on tasks)Arousal-performance: SMR = brakes (calms overarousal); beta = accelerator (fixes underarousal); no fixed sessions (10 for mild insomnia, 24+ for severe)ADHD insights: Frontal suppressor strip → caudate/putamen/globus pallidus/thalamus loop (excess GABA inhibition); beta magnitude increases (more events, not amplitude)

Schau die Episode auf YouTube anAbonniere den YouTube Kanal und verpasse keine neue FolgeUnterstützt durch Naturecan

本次過年大夥很勇 益生菌百百種，常常不知道怎麼選哪款益生菌是最有效嗎? 善存3效順暢益生菌，雙專利益生菌添加鳳梨酵素，順暢消化好體質，一包三效，有酵才推薦！ 善存70年專業品牌，這款3效順暢益生菌，「雙專利益生菌、搭配鳳梨酵素」幫助你養出消化道好環境#。雙專利益生菌^，讓你代謝順暢#，大大乾淨，維持健康，人自然年輕；還有添加鳳梨酵素，加速分解蛋白質，消化更有感，有酵才敢推薦給你。 另外，善存還有舒眠益生菌，食品級植萃成份，擁有五大晚安因子：添加專利舒眠番紅花*、多國專利益生菌**、GABA***、芝麻素****、色胺酸等，可以幫助放鬆、好入睡！讓你天天吃好安心，想睡就睡、睡醒精神好^^! 好菌天天吃，養成好體質，天天精神好。投資財富靠自己，投資健康就讓善存來幫你！ 新春甚麼攏馬順! 益生菌限定優惠! 即日起到2/28 止, 上momo購買善存/挺立/克補保健產品滿2499就送3效順暢益生菌粉末顆粒40包一盒! 好吃又有效益生菌滿額免費送給你! #改變細菌叢生態、維持消化道機能、調整體質 ^係指Lactobacillus paracasei、Bifidobacterium lactis、Lactobacillus plantarum之專利 ‘維持消化道機能, 維持健康 *植萃番紅花萃取物 **日本、中華民國、美國、中國 ***麩胺酸發酵物(含GABA) ****芝麻萃取物(含芝麻素) ^^晚上幫助入睡、白天精神旺盛 PM-TW-CNT-26-00012 股癌傳送門：linktr.ee/gooaye -- Hosting provided by SoundOn

In this episode, we're joined by Dr. Scott Sherr to break down how the nervous system actually drives performance, recovery, sleep, and long-term health.We dive into sympathetic vs parasympathetic balance, why being overly stimulated before training can limit gains, how to down-regulate between sets and after workouts, and why many people struggle with sleep even when they “do everything right.”We also cover cortisol rhythms, late-night training, GABA, melatonin misconceptions, recovery strategies, and why optimizing health isn't about one supplement—it's about the whole system working together.Special perks for our listeners below!

Send us a textSecure the best price for the Hormone Harmony Summit!!!Get your All Access Pass to the Hormone Harmony Summit for the lowest price now:Hormone Harmony SummitMenopause isn't a list of symptoms to tough out—it's a whole‑person transition that touches sleep, mood, metabolism, and identity. We pull back the curtain on what actually changes during perimenopause and menopause, why “I don't feel like myself” is a valid signal, and how to turn overwhelm into a grounded, practical plan you can start today.Get your copy of Awakening in Midlife Today.We begin with a candid look at sleep, the hidden driver that shapes anxiety, pain, and focus. You'll hear a striking patient story that shows how decades of poor sleep can ripple into later health, and you'll get simple, evidence‑informed routines to protect circadian rhythm: cutting blue light at night, seeking bright morning light, creating a consistent wind‑down, and building protein‑forward, fiber‑rich breakfasts that stabilize energy and hormones. We connect these habits to nervous system regulation, sharing quick breath practices that fit inside a busy day.From there, we move into mental health and identity. Hormone fluctuations influence serotonin and GABA, which can intensify irritability, low mood, or brain fog—especially if you live with depression, anxiety, or bipolar disorder. We talk therapy tune‑ups, medication reviews, and boundary setting that respects recovery. Then we tackle stubborn myths: that it's all in your head, that normal labs mean nothing is wrong, that weight gain is laziness, or that you just have to endure. You'll learn a three‑layer model—body, emotion, identity—to map what's changing and choose next steps with clarity.If you're navigating hot flashes, sleep disruption, mood swings, or a shifting sense of self, this conversation offers compassionate guidance and actionable tools. Join us to reframe midlife as a portal to power, not a deadline. Subscribe for more grounded conversations on women's health, share this with a friend who needs it, and leave a review to help others find the show.Welcome to the Art of Healing Podcast community. This podcast is devoted to helping you find what works on your journey to health and wellness. This podcast is devoted to providing information on many healing modalities. Learn more about:ReikiFunctional MedicineMeditationEnergy Healingand more!Learn more about Dr. Charlyce here. Never miss an episode of Art of Healing Podcast...the podcast devoted to helping you heal your mind, body and spirit.Sign up for my weekly newsletter, and never miss an episode along with other great content:Art of Healing PodcastStay in touch socially here:Healing Arts LinksLearn more about me and my offerings here:Healing Arts Health and Wellness

In today's episode, Gina discusses the detrimental role alcohol can play in our anxiety formation and how taking a break from alcohol consumption can contribute to our anxiety recovery. During the initial phases of effects of alcohol consumption, anxiety can be relieved, but the after effects are quite the opposite. Over time, alcohol intake can make us less resilient to stress and more likely to make anxiety a chronic condition. Listen in to learn more about the effects of alcohol and how to take a break to see how you may benefit from less alcohol intake!Please visit our Sponsor Page to find all the links and codes for our awesome sponsors!https://www.theanxietycoachespodcast.com/sponsors/ Thank you for supporting The Anxiety Coaches Podcast. FREE MUST-HAVE RESOURCE FOR Calming Your Anxious Mind10-Minute Body-Scan Meditation for Anxiety Anxiety Coaches Podcast Group Coaching linkACPGroupCoaching.comTo learn more, go to:Website https://www.theanxietycoachespodcast.comJoin our Group Coaching Full or Mini Membership ProgramLearn more about our One-on-One Coaching What is anxiety? Find even more peace and calm with our Supercast premium access membership:For $5 a month, all episodes are ad-free! https://anxietycoaches.supercast.com/Here's what's included for $5/month:❤ New Ad-Free episodes every Sunday and Wednesday❤ Access to the entire Ad-free back-catalog with over 600 episodes❤ Premium meditations recorded with you in mind❤ And more fun surprises along the way!All this in your favorite podcast app!Quote:The body always leads us home… if we are willing to listen.-Thomas HüblChapters0:26 Introduction to Anxiety and Alcohol3:19 Understanding Alcohol's Initial Calming Effects6:27 The Rebound Effect of Alcohol9:37 Changes in Sleep Patterns11:16 Subtle Shifts After Alcohol Abstinence12:25 Supporting the Nervous System13:39 Reflective Journaling Prompts15:12 Closing Thoughts and AlohaSummaryIn this episode, I delve into the intricate relationship between anxiety and alcohol consumption, particularly focusing on what occurs when one decides to reduce or suspend their drinking, even temporarily. Alcohol is often a topic that merits discussion in the realm of anxiety coaching, and rather than applying any moral judgment to its use, I approach it with curiosity and a desire to understand how it impacts our nervous systems. Life can be overwhelming, and understanding how alcohol intertwines with anxiety offers a chance for relief and healing.I start by addressing a fundamental aspect: the sense of safety. While many anxiety triggers often stem from perceived dangers, I encourage listeners to acknowledge that if they are tuned in, they are likely safe. Establishing this baseline of safety allows us to explore the potential effects of alcohol on mental health without the cloud of past judgments or shame. The intent isn't about completely abstaining from alcohol forever or adhering to strict rules, but rather understanding the nuances of how alcohol can provide temporary relief but ultimately disrupt our nervous system balance.What unfolds in our discussion is a deep dive into the neurochemical effects of alcohol. Initially, alcohol may appear to alleviate anxiety due to its qualities as a central nervous system depressant, which increases the calming neurotransmitter GABA while dampening glutamate signals that drive anxiety. This biological response can create a temporary reprieve from anxious thoughts and social discomfort. However, this calming effect is short-lived, and as the alcohol dissipates from the body, a compensatory rebound occurs, leading to heightened anxiety, increased stress hormones, and disrupted sleep patterns.#AnxietyRelief #AnxietyCoachesPodcast #AlcoholAndAnxiety #NervousSystemRegulation #Hangxiety #SoberCurious #DryJanuary #MentalHealthMatters #NervousSystemHealing #CortisolControl #GABA #Glutamate #MorningAnxiety #StressManagement #HolisticHealth #MindBodyConnection #SelfCareJourney #EmotionalWellness #Sobriety #HealthyHabits #MentalClarity #SleepHygiene #AnxietySupport #HealingJourney #OvercomingAnxiety #BrainHealth #WellnessTips #InnerPeace #CalmDown #StressRelief #VagusNerve #SomaticExperiencing #Mindfulness #HealthAndWellness #AlcoholFree #BiohackingMentalHealth #SelfGrowth #MentalHealthAwarenessSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

94% of U.S. adults are metabolically unhealthy. In this episode, I sit down with Dr. Scott Sherr, internal medicine physician and hyperbaric oxygen therapy expert, to unpack how damaged mitochondria, toxins, mold, and chronic stress trap the body in a sympathetic “spiral of doom,” making true healing impossible. We explore why trying to calm the nervous system without cellular support can backfire, the overlooked role of GABA in mood and sleep, when hyperbaric oxygen actually helps, and practical strategies to finally shift out of survival mode, because taking care of yourself isn't selfish, it's the foundation of real health.

Jaume Segalés y los responsables de Mundo Natural hablan de la salud.

Join QEEG legend Jay Gunkelman (500,000+ scans) and Dr. Mari Swingle (i-Minds author) with host Pete Jansons for a deep morning dive into EEG patterns, drugs, and brain dynamics.✅ Topic 1: Delta Waves – What They Really MeanDiffuse/global delta: lack of white-matter input, sheet dipoles, parenchymal layersInfra-slow oscillations (less 1 Hz): oxygenation cycles (Yuri Crop), 6 breaths/min resonanceClinical implications: encephalopathy, developmental vs acquired✅ Topic 2: Alpha Blocking & ReactivityBurger effect: eyes-open alpha attenuation ≥50% at O1/O2/PzNon-responsive alpha phenotype = severe disconnect from external worldLow-voltage fast EEG: over-arousal, GABA can slow & reveal alpha✅ Topic 3: Psychedelics & Hallucinogens on EEGDramatic connectivity changes vs medicationsSalvia: gigantic 6–10 s slow waves (600–1000 µV), dissociationRisk: epileptiform activity + DMT/MDMA/psilocybin/ketamine = major contraindicationLow-dose LSD: possible anticonvulsant effect (historical Larry Rouse study)✅ Topic 4: Cannabis (Weed) – Acute vs Chronic EEG EffectsAcute: slows background alpha → helps sleep onsetChronic (Struve work): increases frontal alpha coherence → risk of apathy, depression, affective dysregulation (especially if baseline alpha already high/fast)✅ Bonus NuggetsHRV–EEG overlap: cardio-ballistic artifact, pulse artifact, vagal slowingStatic electricity on hair: minimal issue with proper groundingCarl Pribram memory: holographic storage, traveling waves (John Hughes), personal anecdotesFuture EEG trends: less alcohol → more THC? Shift toward frontal coherence issues

TJ loves him some Weekly World News, and gives us his roundup of the weird, bizarre, and hilarious. Then on a more serious note he talks about the missing mother of Savannah Guthrie. Gaba brings up an interesting topic, the "Walking School Bus Program", and an email bag. All this and more on News Radio KKOBSee omnystudio.com/listener for privacy information.

Beverly Meyer is a certified clinical nutritionist and podcaster who focuses on helping people through food. Her work in nutrition focuses on improving mood and sleep through specific foods and nutrition plans.    You can follow Beverly's work at https://www.ondietandhealth.com/ Her podcast Primal Diet - Modern Health is available on most podcast platforms.    Want to watch the video? Check out the discussion on YouTube: https://www.youtube.com/@mentalmapspodcast   Mental Maps is brought to you by Arukah Well, a virtual holistic mental health service. To learn more check out www.arukahwell.co or on Instagram @arukahwelllife   keywords: clinical nutrition, mental health, GABA, blood-brain barrier, anxiety, paleo diet, brain health, herbal remedies, nutrition, food quality

Dr. Vaish Sarathy speaks with Dr. Kendall Stewart (former surgeon turned functional medicine + genomics clinician) about the biochemistry of learning: how inflammation, metabolic factors, neurotransmitter balance, and genetics can influence regulation, sensory stability, and why some kids respond to interventions while others don't. What we cover: Why progress can look like "good days/bad days" when inflammation fluctuates Nutrigenomics vs exome sequencing vs pharmacogenetics (and why personalization matters) A parent-friendly clinical framework: inflammation → autophagy/insulin tendencies → neurotrophic factors → glutamate/GABA → methylation Sensory stability (vestibular/visual) and why eye contact can reduce listening for some learners Microbiome basics: inflammation load, butyrate, absorption/biofilms Resources Dr. Kendall Stewart: https://drkendallstuart.com Non Linear Education (NLE): https://www.drvaishsarathy.com/nonlineareducation Medical disclaimer (important): This episode is for educational purposes only and does not provide medical advice, diagnosis, or treatment. Always consult your qualified clinician for medical decisions—especially for children and complex conditions.

The following is an AI-generated rough transcript of the Equipping Hour. It may contain inaccuracies.  Opening and Introduction Smedly Yates: Well, good morning. Happy Sunday. Welcome to Grace Bible Church this morning and to Equipping Hour. This morning, we’re going to be doing a follow-up from an equipping hour that Jake taught on January 11th on dementia. And that was, Jake, that was riveting and encouraging. And I thought you taught us everything we needed to know, but apparently you didn’t. Because the numbers of follow-up questions from that equipping hour broke all records. So we’ve sort of accumulated those questions. And let me just encourage you, if you didn’t get a chance to listen to that equipping hour from January 11th, pull it up on the website, go back and listen to that. And this morning, what we’re going to do is just put the questions that many of you asked in person and submitted. Or just get to ask those of Jake in front of all of us. And so Jake really is going to give most of the answers here. I don’t know if I have a whole lot to say. Other than these are the questions we got, Jake, help us. So with that, let me open us in a word of prayer and we’ll get started. Heavenly Father, thank you so much for your kindness to us. We don’t deserve to have physical ability endure in this life. We don’t deserve to have mental capacity sustained in this life. We truly only deserve condemnation under your wrath for our sins. And so anything that you give to us, we pray to use as a gift, as a stewardship, to use well and for your glory, and to be content and to trust you as things diminish. And we thank you for the preparation, for mental decline. You’ve already given us from principles from your word. We pray even now as we discuss caring for one another and seeking to glorify you in personal worship in our physical existence that you would be honored as we listen and apply and are strengthened and sharpened to help others. We ask all this in Jesus’ name. Amen. I’m going to start with kind of a personal question that came in, Jake, and it goes like this. If I try not to get dementia, you gave us a lot of helps, dietary exercise, sleep, some of those things that were really helpful, practical things. So if I’m doing those things, if I’m trying not to get dementia, am I expressing distrust and dissatisfaction in God and his sovereignty? Stewardship, Planning, and God’s Sovereignty Jacob Hantla: Maybe. So, yeah, we spend a lot of time talking about the practical ways that you might want to steward this life and this body that God’s given you. The big hitters were exercise, right? We said if there’s one that you can do, it’s that. But there’s a lot more. There’s a, but if you’re doing those things, is that sinful? It might be. There’s a way to do the right thing for the wrong reasons. Planning, though, is not unbelief. Planning like God doesn’t exist is unbelief. or planning like God’s way isn’t best in your selfishly, arrogantly grabbing after your own desires. That’s unbelief. That’s sin. So the issue isn’t whether you should steward, but it’s whether an action that you’re saying is stewardship is actually a mask for control, pride, and fear. Proverbs 27:12 says the prudent sees danger and hides himself. There’s a way to see that. Where you see danger, you hide yourself from it. You take planned steps in order to avoid it that actually roots itself from fear of the Lord. And that would be right. And in contrast, it says the simple go on as if that danger isn’t there and they suffer for it. So there’s nothing inherently righteous or right and just saying, I’m going to trust the Lord and use that as a mask for just lazy thoughtlessness. Similarly, there’s nothing righteous at all in saying, I don’t want what I fear is coming and I’m going to grasp after what I want. But James 4, you guys might want to open there. This is, a really, really helpful section of scripture for planning. And it reveals why we actually have to, at the heart of all of this, guard our hearts, not merely do the right thing. James Chapter 4. And this is in the context of the warning, or the command to humble yourself from verse 10, humble yourselves before the Lord because God resists the proud and gives grace to the humble. And now, he says, come now, verse 13, you who say today or tomorrow, we’re going to go into such and such a town, spend a year there trade, and make a profit. Yet you do not know what tomorrow will bring. What is your life? You’re a mist that appears for a little time and then vanishes. Instead, you ought to say, if the Lord wills, we will do this or that. So the take home from that is not don’t plan, don’t run a business, but rather as you run it, run it as one who actually embraces and recognizes your temporalness, your weakness, your dependence, and God’s sovereignty. Smedly Yates: If we zoom out from the topic of dementia, and we just think about the principle underlying that, we’re dealing with the realities of God using human means in his sovereign plans. If we rephrase the question, we might say, is it sin and distrust of the Lord to study for your chemistry exam? No, of course not. Can you sin by studying for your chemistry exam without thought toward God and exalt your own pride and intellect and your hard work? Yeah, that’d be wrong. A godless, practical, atheistic approach to effort would be sin. But a laziness that says, well, I’m just trusting in the Lord, but I’m not going to go apply for a job, study from my exam, practice for the athletic endeavor, or whatever is sin the other way. And I love the example of evangelism. We know that God will save people, but we know that God uses means to do it. So is it a failure to trust God when I go out and share the gospel with people? No, it’s actually the obedience that God uses as a means to accomplish his ends. Now, I can’t control the results. So you can be faithful, worshiping the Lord, telling others how great Jesus is all day long and nobody gets saved and God is honored and we trust him. Jacob Hantla: Yeah. There’s two biblical, I love the illustration. It’s throughout the Bible of horses and chariots. You can write down Proverbs 21:31 and Psalm 20:7. In Proverbs 21:31, it says, the horse is made ready for the day of battle. Who does that? We do that. The people do that, and they go, battle, but it says, but victory belongs to Yahweh. And similarly, in Psalm 20:7, this, this was actually one of my favorite passages in fighting cancer. I stole it from Piper in his book, Don’t Waste Your Cancer. He says, some trust in chariots, and some in horses, but we trust in the name of Yahweh our God, which doesn’t mean go to battle with slow horses and broken down chariots, it’s wise to get the best you can. If you know that you might be facing a future with dementia or anything else you might face, chemistry test or other health problem, be diligent to plan, but do it in a way that when you don’t get dementia, it wasn’t your effort that gets the glory. It was Yahweh’s. And if you get dementia anyway, you say, it was the Lord’s will. It’s best, I trust. Reverse Sanctification and Dementia Smedly Yates: A question came through, and really there were several facets that sort of get at the same kind of question. But people wondered, and this comes obviously from people who have worked hard to care for people with various forms of dementia. But it seems like Christians at times can experience what looks like reverse sanctification. Is that what’s going on there? Have people been abandoned by the Holy Spirit when behaviors change in mental decline. Jacob Hantla: Yeah, I think probably about five, six of you asked that question with very particular circumstances in mind. And the question doesn’t overstate the reality of what occurs. So reverse sanctification. Sanctification is the process of progressively being conformed to the image of Christ from the point of salvation, usually, and normally for a Christian, until the point when they finish well, die, and are taken home, and then glory. But that doesn’t always happen for Christians. The reality is sometimes in dementia, some Christians become more childlike in their faith. It’s not inevitable that your sanctification will reverse. And I don’t think that’s the right term. It’s the observed reality that we see. But sometimes their faith becomes more simple, but not less godly. They might tell the same stories over and over again. Or if you imagine sometimes what happens in dementia, your existence in the moment is separated from what’s gone before it. So you’re always disoriented. That’s terrifying. And so you see the Christian in those moments having a childlike trust questions that you feel bad for them, but they are trusting the Lord in a real way. But sometimes, and this is the words of Dr. John Dunlop, wrote a book on the Christian and dementia. He goes, dementia can indeed change personalities. It has transformed wonderful, loving, godly people into tyrants. And that happens. I’ve seen, you see somebody who was self-controlled loving. and as they progress into dementia, they curse. They use language that’s not befitting a Christian at all. There’s inappropriateness in all kinds of ways. And so what’s going on there? I think it’s helpful. I’m going to do another physiology lesson. Bear with me, I promise it’s worth it. It helps me. So there’s some types of dementia, especially that there’s one we talked about called frontotemporal. What does that mean? It’s the area of the brain in which it happens. And it changes the way that your brain physically works. So there’s an, I’m going to oversimplify a little bit. So, but this is, this is helpful. If you think of your prefrontal cortex, you might have heard that word because we joke. Teenagers, their prefrontal cortex isn’t fully developed. And that’s true. It’s why you don’t trust your kids to make life-altering decisions. But the prefrontal cortex is, you could think of it as the executive control center of your brain. It houses the part of your brain for abstract thought, concentration, working memory, and most critically, inhibition of inappropriate thoughts and actions. You and I do it all the time you think it’s like the breaks. There’s a filter on, thank God there’s a filter, right? Something comes to your mind and it doesn’t come out your mouth. Because of the prefrontal cortex, it overrides automatic impulsive thoughts. It helps you consider the consequences in the future before acting. It connects your current behaviors to the past experiences and your goals. And when that area is damaged, somebody has a really hard time choosing the appropriate behavior for the situation. The damage, it sort of removes the filter. There’s another thing, orbital frontal cortex. It’s just another area of your brain. You don’t need to know the big word. But what that is is that’s particularly critical for regulating social behavior. When that area of the brain gets damaged, like if you get a cancer to that area or a surgery that affects, that area instantly, that person can explain what appropriate social behavior is, but they don’t recognize when their behavior violates that. So it’s manifested by like just a list from a textbook that I looked up on this. It’s greeting strangers in an overly familiar manner, standing too close to others, inappropriate touching, being aware of social norms, like I said, but unaware that your behavior violates that, and that can go to extremes, sexual inappropriateness, language inappropriateness, and they’re just unaware. You and I, if we were to be saying that, it would be sin. In this case, it actually may represent a physical inability. So what’s going on there? I want to think about the brain and the believer. When the Holy Spirit expresses self-control in a believer. So, right, the fruit of the spirit is self-control. And I just said, well, self-control comes from the prefrontal cortex. So are we just our brains? No. When the Holy Spirit makes a believer new. And when the Holy Spirit controls that believer, he does it in a way through the working of our physiologic brain that enables us to submit to him, which means that he’s actually using our prefrontal cortex in a renewed way. I think it’s helpful. Open your Bible’s to Ephesians 5:18. I think this is really helpful. And there is an inner working between the way our brains and our most inner us, your soul, your mind, you’re who you are. There’s a working there that we, don’t truly understand, but that we can get glimpses into here. And I think that that, if we think of the way our brains in the working of the Holy Spirit to accomplish things like self-control, I think this is a helpful verse. Ephesians 5:18, do not get drunk with wine, for that is debauchery. And what’s that contrasted with? But be filled with the Holy Spirit, with the Spirit. So what does alcohol physically do? Alcohol in a person, it actually, you’re going to now see why I did this physiology lesson, it actually dramatically reduces prefrontal cortex activity. It takes the break off. It takes the filter off. You may still have the Holy Spirit, but the physiologic means that he uses to exercise control of, you would use to minimize your expressions of sin while in this body that’s falling apart, you’ve now chemically altered that. And so you have a lack of self-control, an impaired moral reasoning, increased risk-taking. Similarly, your orbital frontal cortex goes dysfunctional. That’s why I mentioned those two things. That happens with alcohol and anything that stimulates GABA receptors. That would be like benzodiazepines, some sleeping pills, some anti-enactylase, some anti-enactylase. anxiety meds, it can lead to social inappropriateness for those same reasons. Opioids. Research shows that chronic amphetamine and opioid use alters decision-making by ways that are very similar to focal damage to that orbital frontal cortex. You can see now chemicals interacting with your brain in a way that we’re used to seeing those people don’t act right. THC from marijuana, same thing, decreased brain volumes in chronic use, especially in the orbital frontal cortex. Sleep deprivation. Tons of breakdown, temporary, and the connection between amygdala, which is like your fighter flight, your stress area, and your prefrontal cortex connectivity. So sleep deprivation triggers this. You basically don’t have a brain. on your emotional regulation. So why am I going through all that? If we have the ability, it’s right for us to keep ourselves from breaking our brain intentionally. Don’t be drunk. Avoid chemicals that would alter those areas and make the expression of self-control more difficult or less likely. and you can actually, you see it in your kids when they’re unslept, more prone to sin. You see it in yourself. So imagine yourself with 48 hours without sleep, then drink a little bit of alcohol. You will become disinhibited, irritable, and be much more prone to sin. Don’t do that to yourself. But now what happens if that’s actually happening physically because areas of your brain are dying, they’re tangled up with proteins, or they’re otherwise that they can’t access the energy stores to function? That’s effectively what they’re, but they can’t sleep it off or sober up. It helps you be probably a little more understanding and maybe see that it’s not actually a reversing of sanctification, but rather, I think it’s a, well, let’s just turn to 2 Corinthians 4, and I think we’ll see what it is. You see that dementia can change behavior by damaging the brain’s physiologic instruments of restraint and judgment, but it’s not the same thing as the Holy Spirit moving out. sanctification isn’t stored in a lobe of the brain. You are more than your brain. It’s actually our brain is that part of us that’s wasting away. It’s not our inner man. So 2nd Corinthians 4:16, we do not lose heart. Though our outer self is wasting away, our inner self is being renewed day by day. day. This is helpful to remember in somebody whose outer self is falling apart, not just physically their body doesn’t work anymore, but their brain’s not working. This light momentary affliction is preparing for us an eternal weight of glory beyond all comparison. As we look not to the things that are seen, but the things that are unseen, the things that are seen are transient, but the things that are unseen are eternal. It’s really helpful. when we look at somebody with dementia and it looks like they’re becoming less and less Christian. I love the way John Piper says it. He has a helpful ask Pastor John on dementia. And he says, Paul’s telling us that weak, in glorious, demented shadow of a once strong Christian in front of us is on the brink of glory and power. You need to go into nursing homes and think that way. These people are on the brink of glory and power. We must keep this continuity in mind between diminished powers of human beings here and the spectacular powers that they’re going to have in the resurrection. It’s so important if we lose a sense of that continuity for the Christian, will assume that we are becoming less human rather than being on the brink of gloriously superhuman. So it’s helpful to see that your brain is the outer person that’s wasting away. And that isn’t necessarily connected to the what God has done in the most inner you. Confrontation, Rebuke, and Care for the Weak Smedly Yates: Given that reality, Jake, we think about somebody whose inhibitions are broken down. The manifest ability for self-control allows things in the heart to make their way out. Is there ever a place for confrontation, rebuke, encouragement, help for somebody who’s still living the Christian life, still susceptible to sin? At what level is it appropriate? How should we think about, you know, helping behavior and rotten speech and things like that? Jacob Hantla: Yeah, absolutely. There is. You have to recognize that the purpose of rebuke would be repentance, right? And just like with children and with all Christians, it’s really wise and necessary to discern when possible between sin and inability. The reality is that we can’t always do that. But before I go there, I want to get back to this question. Let’s think about ourselves and what we’re going to be prone to do with what I just said. I’m going to be prone, you might be prone, to say, well, I didn’t sin. It’s just my physiology that made me do it. You don’t get off the hook ever in the Bible because your physiology had a weakness. God uses our weakness and our physiology as the platform in which he demonstrates his power, and particularly his power over sin. Our brains, actually a significant part of why they’re weak and why they break like this, is because it’s a part of God’s judgment for us. Romans 1, right? We became futile in our thinking, and our minds were darkened as a result of our unwillingness to acknowledge God as God. We are not merely our brains, and yet the dysfunction of our brains is actually a significant part of the fall. God renews that. He changes that in the believer. And if you as a Christian say, I know where I am particularly vulnerable, maybe I’m heading down a path towards dementia, or maybe I have some particular weaknesses where I haven’t slept much this week. I just had back surgery. I know I’m going to be on an opioid for pain, and I know that I’m going to have a particular—even if you can’t say the area of your brain that’s going to not function right—you're going to say, all right, Jake taught me that I’m going to tend to act inappropriately towards people. I’m not going to view myself rightly. I’m going to have a lack of self-control. I better ask for help. I’m not going to justify sin, but I’m actually going to be more vigilant for it. Fight it more diligently and get people around me to help me fight it. So now let’s go to the question of, is it ever appropriate to rebuke a dementia patient? Let’s assume that person is a Christian. Go to 1 Thessalonians 5:14. If that person is a Christian and they are sinning, even if they’re not even aware of it, they’re going to say, will you please come to me and help me? I’m going to need help. We need to, as best we can, use the right tool for the situation. Discern weakness, faint-heartedness, and still don’t hesitate to admonish unruliness or idleness. So 1 Thessalonians 5:14: “We urge you, brothers, admonish the idle or the unruly, encourage the fainthearted, help the weak.” Do you see those three different instructions? Somebody might be expressing sin. All three of these might be evidences of—in all of these three cases—there might be somebody evidencing unbelief or something that needs turning, changing. And in one case, the tool is admonishment. In another, it’s actually help. And in the other, it’s encouragement. Now consider the person with dementia. Their brain is not functioning the way that yours is. They can’t connect their actions to what’s socially appropriate. They can’t connect their actions with the goals they’re aiming at. They might be unclear as to even the situation that they find themselves in, the context of their life. That’s a pitiable—in all the right ways—pitiable circumstance. That would tend to make that person fainthearted, very weak. What they probably need more than admonishment is help and encouragement. I love Poithress. This is from Piper and Grudem’s book, Recovering Biblical Manhood and Womanhood. He says, “Our privilege as Christ’s children altogether should stimulate rather than destroy our concern to treat each person in the church with the sensitivity and respect due to that person by reason of his age, gift, sex, leadership status, personality,” and I would add mental status. So how should you do this? With mild impairment, let’s just go down a category. If you had somebody with mild impairment—not all dementias, it’s not this catch-all where everybody’s all the same—you can have a mild impairment. Probably normal accountability. They’re going to tend to need more admonishment and help and encouragement, but be slower, be gentle, be more concrete. You’re probably not going to be able to string together three or four if-then statements to logically get them there. Make it simple. Sort of like when you’re admonishing your three-year-old, maybe your five-year-old, your seven-year-old. You still do it, but not in the same way that you would a 25-year-old or a 35-year-old. But then with moderate impairment, your correction probably becomes more redirection. Just simple statements of, “That’s not okay. Let’s go over here.” Change the environment. And then severe impairment, probably treat it more as symptom management, prioritizing safety, comfort. Simple statements still: “That’s not okay.” Like you would use for your one-year-old: “Use your hands for gentleness. We don’t speak like that. That doesn’t honor the Lord.” Normal Aging, Forgetfulness, and Dementia Smedly Yates: Statements like that. This is so helpful, Jake. I think partly because we don’t want to be in a position where we’re shocked and our black-and-white categories of sanctification, justification, get in the way of compassionate care and love for someone who is in a weakened state that needs help. It’s not dismissing sin, but just really helpful, compassionate care. I have a more personal question for you. Last evening, we had a number of friends in our home, and I got confused and thought that a dear sweet friend was somebody else altogether. And it occurred to me later, I asked a really strange question that didn’t make any sense to her at all. Do I have dementia? Jacob Hantla: I don’t think so. But you are getting older. There’s a forgetfulness that’s just a part of being human. And there is a forgetfulness that’s increasingly normal with age. Smedly Yates: You’re right behind me. You’re catching up. No, you’re not catching up, but you’re behind me. Jacob Hantla: Percentage-wise, I’m catching up, and I will never in an absolute, absolute way. So there’s normal aging, and some normal cognitive decline with aging is very different than actual dementia. So if you do have questions about that, it’s helpful. Regardless, if you just say, hey, I’m getting old. I’m not sleeping as well. Just as a result of not sleeping as well, as a result of just being weaker, maybe having more history behind you, some more stuff to forget, or whatever, you realize, hey, I don’t have dementia, but I’m not who I once was. That’s not a bad place to be. There’s a weakness there that’s helpful to get people around you to augment your weaknesses. How much more, if you were heading toward dementia. I promise I’ll tell you if I see it. You do the same for me. But regardless, you might or you might not. I don’t think you do. But let’s say that you’re saying, I forget stuff, do I have dementia? The second that you start thinking that, you’re probably not the right person to be making that call. It’s wise to get family members, elders, even medical professionals, doctors to assess: is this dementia? Is it a reversible cause? What’s the probability it’s going to accelerate? And then as you start seeing more and more likelihood that, yeah, this is progressing, start getting people around you to start relinquishing intentionally controls that you might have on your life. Can you double-check me on any purchases greater than X amount of money? Let’s go update the will. Let’s get you on a power of attorney. Invite them to take away the keys at the appropriate time. Even if you say that’s a long way from now, that’s a really humble way to invite, in a godly way, people who love you to be enabled to help you. Forgetting the Gospel and Childlike Faith Smedly Yates: Jake, can a believer forget the gospel in a mentally diminished state or not have the ability to articulate the gospel? Jacob Hantla: Yeah. They can. Memories are stored in our brain. And you might not have access to those memories even while you are saved. Right? That unbreakable chain of salvation will end in glorification from Romans chapter 8: all those whom he foreknew, and it gets all the way to glorification. And in the midst of that may be a trial like your memories are disconnected from you in a way that you can’t explain concepts like substitutionary atonement, you might not even remember that Jesus is your Savior, though he is. And so if somebody has forgotten those things, don’t tire of reminding them of those things. Because even if that memory can only stay with them for that one moment, it’s real. And it might help them endure that moment. It’s a really complex, I can’t say that we understand it at all. But God does. There’s a complex relationship between our thoughts, our memories, how those connect to our actions, and what our ultimate status before God that’s normally expressed through faith. And you can’t have faith without trusting in Jesus. So how can somebody who doesn’t even know who Jesus is trust in him? I’m just going to say I’m not God. God knows. And when you are in your right mind, if you do, that’s evidence of God’s work in you. Because nobody can say Jesus is Lord apart from, in me, and being it, apart from God changing them, saving them, making them new. And so if their brain breaks, and they no longer are able to say that in the same way, I don’t think that’s going to be devastating because they weren’t saved on the merit of faith, but they were saved by grace through the exercise of faith. That faith may look different now. But it’s helpful to think of what kind of people go into the kingdom. Like the disciples, when the children were coming, and they said, no, don’t let them near. And Jesus says, no, it’s, it’s that kind of person who gets into the kingdom. Don’t think that those, faith doesn’t have to be complex. Faith doesn’t have to be well reasoned out. That doesn’t mean that you have an excuse not to think. Peter says, add to your faith knowledge, right? We are expected to grow in faith. I’d love to hear you expound on this, Smed. But there’s a childlikeness of faith that actually in your dementia, you might be able to express that. In your arrogance, maybe in your self-trusting when your faculties are working, it may actually be God’s means of separating you from your strength, because when we’re weak, we’re strong in him, that we don’t get to see all the interplay of that, but we may be a means moment by moment of reminding the Christian who forgot who Jesus was of who he is. Smedly Yates: I think that’s so helpful. The weakest place you will ever be in life are at your last moments on the earth. No matter how it is you go out of this life. Just last night I was working through the details of the resurrection in 1 Corinthians 15. And listen to this, Paul is comparing the resurrection to a seed sown into the ground and then what comes out afterwards. And there are different levels of glory from sun, moon to stars, different kinds of bodies, fish, and other things. But not everybody’s the same. But every human being who faces physical mortality ends life here and then experiences resurrection, every one of us will experience the most profound weaknesses in the last moments. And here’s how Paul describes it. The body is sown, placed into the ground like a seed, corruptible. Subject to absolute humiliating corruption, raised incorruptible. No longer ever subject to corruption. And when we think about brain deterioration, that word corruption is weighty. Sown in dishonor. The last moments of anyone’s physicality are the most dishonorable. Stripped of power, stripped of strength, stripped of dignity, but raised in glory. And Jake, what you shared earlier about somebody being on the brink of the kind of glory that C.S. Lewis described—if we were to see a resurrected saint now we’d be tempted to fall down and worship them or run away in abject terror. We just have no idea what this glory is like on this side of it. But we go from the lowest, most undignified, most powerless spot in our earthly existence in those last moments. And he goes on and says, put in the ground in weakness, raised in power, put in the ground natural, raised supernatural. And so the earthy is first and then the spiritual. And so it’s just helpful to think about not being surprised when someone is at their most profoundly weak, not just physically but mentally, end-of-life scenarios. Jacob Hantla: Yeah, it’s profoundly humbling. And it makes us want to say, I don’t want to be there. Can I avoid that? Okay. I mean, do your best. And ultimately God may bring us there in a way that all of us, sometimes our last moments are momentary, sometimes our last moments of that corruptible humiliation last a really long time. In this tent we groan, longing to put on our heavenly dwelling, if indeed by putting it on, we may not be found naked. For while we are still in this tent, this physical body that’s falling apart, we groan, being burdened. Not that we would be unclothed. It’s not merely saying, hey, let’s take this thing off, but that we would be further clothed so that what is mortal may be swallowed up by life. It’s not even worth comparing. And so if that’s the way that God has to be glorified in us—to go back to that first question—okay, I’ll do that. It’s light and momentary, even if it lasts a long time. And even if I’m not even able in the moment to contemplate what time is, it’s humiliating. And you know what? I’m going to ask the Lord to take that from me. I’m going to say, God, please don’t. That’s an okay prayer. That’s similar to what Paul prayed and said in 2 Corinthians 12. And Jesus says, no, my grace is sufficient for you, for my power is made perfect in weakness. And if Jesus says that to you, Christian, you can say, okay, I’m going to be content with weaknesses. And man, if you get to care for somebody in their weak moments there, it’s helpful to have these things in mind to know they’re on the brink of glory. Marriage, Roles, and Dementia Smedly Yates: I want to move to a practical and theological question related to roles, thinking particularly about husbands and wives honoring biblical roles in marriage, particularly when a husband is experiencing mental decline and dementia. How does a wife caring for a husband honor those roles with a diminished ability? Jacob Hantla: Yeah, that’s a really helpful question. I loved thinking through this. Smedly Yates: I came up with it myself. No. Several people asked. I just wrote it down. Jacob Hantla: You did. I think we want to avoid two opposite errors. One is a view of submission and leadership as a rigid subservience. If a husband can’t lead, the wife can’t act. Or on the other side, a role evaporation. That illness or inability cancels biblical patterns. Both of those would be absolutely wrong. Did you get that? One would be if the husband can’t lead, then the wife shouldn’t be able to act. And if the husband can’t lead because of inability, role distinction, that God set out that is grounded in creation order, not in ability, right? Men aren’t pastors because we’re better at it or smarter at all or better teachers. That’s not where God grounds it. But in his purposes. And so it’s helpful. If we think about what femininity is, so we’re helping a wife whose husband is just incapable of leading in the ways that she wishes he could, a heart that longs to follow. You think of 1 Peter 3:4. The adorning for the woman is in the imperishable beauty of a gentle and quiet spirit, which in God’s sight is very precious. Normally, that’s going to be expressed through submitting to husbands, to their leadership, even in ways, as long as their leadership—for unbelievers, as long as their leadership doesn’t lead them to go against the Lord—even submitting to that with a gentle and quiet spirit. That’s going to play itself out differently for a husband who can’t lead through inability or poor decision-making due to brain decline. You go to Proverbs 31. This breaks the category of a submissive wife as one who’s subservient and just says, “Tell me exactly what to do, so I only do that thing.” No, an excellent wife who can find, she’s far more precious than jewels. The heart of her husband trusts in her. He will have no lack of gain. She does him good and not harm all the days of her life. You see right there a husband who can trust his wife, whose wife is working for his good and not harm, that’s a wife who’s embraced godly roles. It’s not a wife, it’s not neediness that she expresses, but productivity and care. Jump forward to verse 15 of Proverbs 31. She rises while it is yet night, provides food for her household, portions for her maidens, she considers a field and buys it, the fruit of her hand, she plants a vineyard, she dresses herself with strength and makes her arms strong. She perceives that her merchandise is profitable, her lamp does not go out at night. This is a woman who can work, who can work hard, but very different from that which feminists would say, hey, a woman who doesn’t need a man, a woman who functions for her own good, depart from him, but this is a woman who’s functioning strong for the good of her husband. And her husband trusts, she, verse 27, looks to the ways of her household. She doesn’t eat the bread of idleness. Children and her husband call her blessed and praise her. Charm is deceitful, beauty is vain, but a woman who fears the Lord is to be praised. This biblical femininity is rooted in fear of the Lord, love of her husband, not a desire to dominate over the husband, but to come alongside as a God-given helper to build him up, that can be demonstrated in very unique, very God-glorifying ways with a husband whose mind is increasingly not working. It’s fundamentally a disposition to honor and support the husband voluntarily and gladly. Leadership often involves delegation. So, husbands: if you’re heading that way, plan in advance for the kinds of ways so that your wife, even when you can no longer give your preferences, she knows, and it seems like in the moment, she’s actually working against it when you no longer understand what’s going on. She’s actually able to follow. So it’s good and right for the wife to be productive, capable, in a way that might look independent, but with a hard attitude that supports. So anticipate that. I want to give a personal example. This is actually hard and a little bit embarrassing. So dementia is different than delirium. Delirium is something that’s short-term, usually from a cause. You see it in elderly when they get like UTIs. You can see it from medications. Post-surgery, I see it all the time with anesthesia. As many of you guys know, I spent a long time in the hospital with Burkitt lymphoma. I was getting a lot of chemo. They stick a needle in my spine, give me chemo directly into my cerebral spinal fluid around my brain. I was on tons of pain medication and all kinds of other medications that did weird things to my brain. I don’t remember this time, but there was apparently a few days—I remember bits and pieces of it—where I was out of my mind. I at one point apparently tried to hit Kiki. I took all my clothes off and tried to go in the hall at the hospital. Kiki was a loving, submissive, supportive wife by helping me not do that. I am very grateful for her tearfully persevering, guarding me from myself as my brain was failing me. At that point, thankfully, in a reversible way. But she was not stepping out of her God-ordained role by saying, “No, Jake, you cannot go in the hall naked. No, Jake, you cannot hit me. Jake, get in bed,” and even physically and chemically restraining me for a time. That was a gracious expression of role differentiation that I think honored the Lord and honored me. I remember also, just husbands to wives, me at the—I was reading my vows this morning from almost 25 years ago. I wrote in those vows. And I’d encourage you guys to think through that now. And singles, as you’re thinking through marriage, think through what it might mean in all the different stages. I said, “I pray that as we grow old together, our love will grow stronger because we are together growing as one closer to Christ. I commit myself to loving you, even when your beautiful body is gone, even when your mind is not sharp, even when you do not recognize who I am. No matter what the cost to me, I will be married to you until God takes you.” And that’s what it means. That love isn’t in it for what the other one can give. It’s not self-seeking. It actually seeks the good of the other. So have this mind in you, which is yours in Christ Jesus, who though he was in the form of God, did not count equality with God a thing to be grasped after, but he emptied himself, taking the form of a slave, being found in human form. He did that all the way to the point of death, death on the cross. That’s what husbands are called to. That’s what all of us are called to. So thinking, I am above changing this diaper or correcting my spouse for the thousand and seventy-second time this week. Stooping that low is nothing compared to our Savior’s humble condescension to us. And so you actually are embracing God-given roles as a Christian when we help and endure and love our spouse to the very end. Honoring Parents and End-of-Life Care Smedly Yates: And that’s a great segue, Jake. When I think about what you just described, our parents did those very things for us when we were helpless. There may come a time where those roles are reversed and we’re helping our parents in their end-of-life situations. I’m going to ask you a series of questions that came in and you can answer whichever ones you want. I’ll try to go faster so we get through them. Maybe. Maybe we do a part 17 of this series, whatever. But I’m thinking about the command, the prohibition, do not sharply rebuke an older man. And the positive commands honor your father and mother. Those commands don’t expire. And when I think about don’t sharply rebuke an older man, there ought to be an elevated view of those who have walked this life longer than we have. We’ve lost that in an American culture, right? Tribal cultures have kept that in some ways. Other places, other cultures have kept that. We just sort of disregard the elderly as a new cultural phenomenon. And, you know, the word euthanasia, the beginning of the word is, is eu or good and thanasia, thanos, death. Good death. It’s not good. And we don’t discard people when they’re no longer of utilitarian purpose. But that is where our culture is going. And Christians must look very different. So when we think about how do we gently, compassionately, lovingly honor God, honor our parents, loving them through end-of-life scenarios. Here’s a series of questions. How do I honor those relationships when compassionate care, sometimes correction, help the 1,077th time. Dad, use your words. Don’t use your hand. You know, whatever it is. Give me the keys. How do we do that and honor them in our disposition? Number two, is it sin to employ the resources of home health care or a live-in situation, a retirement community, etc.? And then what do we need to think about with end-of-life scenarios? Yeah. That’s a lot of questions. Let’s go. Jacob Hantla: Let’s go. So I think honoring your parents means, first off, it’s a disposition of the heart, but it’s a disposition of the heart that is connected to meeting their physical needs. You went to 1 Timothy 5. Do not sharply rebuke an older man, but encourage him as you would a father. And then dot that dot, second, verse 2, older women as mothers. And then it rolls into, let’s think of widows who are truly widows. Open to 1 Timothy 5. This is maybe a section that you’re like, you might not read this honor widows who are truly widows section, thinking it applies to you. It does. And I think in it is the answer to this question, or at least a significant part of it. Verse four, the thought here is the church needs to take care of widows, but don’t do so in a way that robs a family of the responsibility and need to take care of their own parents. So look at verse four. If a widow has children or even grandchildren, let them first learn to show godliness to their own household. And now look at this three part: make some return to their parents. So rooted in just a mom, dad, thank you for however many years of my life. You changed my diapers and fed me and looked after every need. It’s okay if my career is messed up because I have to have you in my home and I have to go take care of you. That is, do you see what it says? That is actual showing of godliness. I love what you just said. It’s so different than the culture. The culture might do this in a way that Christians have to be sharply different than. It is godliness to make return for the way that your parents cared for you. Number two, this is pleasing in the sight of God. You don’t do it out of social obligation—well, who else is going to do it? They don’t have enough insurance. Or even if they do have insurance and you do get the privilege of having live-in help. No, you are seeking to please the Lord as you make return to them. This is pleasing. Yeah, and then the third was, yeah, so godliness, make return to their parents. It’s please the Lord. Take care of your parents. Meet the needs. And if you don’t, verse 8, do you see what it says? If anyone does not provide for relatives, especially members of his household, do you see what you’re saying? You have denied the faith and you are worse than an unbeliever. This is what James is referring to in chapter 2. That’s a faith that’s dead being by itself. The religion, end of James 1, the true religion, takes care of orphans and widows in their distress. How much more are your parents? So, yes, take care of your parents. You have to. It’s a great privilege. It’s actually God’s ordained means of living out godliness. So can you send your parents to a care home? Does that mean you have to maximally sacrifice? Not necessarily. It doesn’t mean that you have to perform every task. Neglect is sin, but using help may be wisdom. The reality is dementia needs are often 24-7. They involve skilled needs at times. They may wander, fall, be incontinent, unsafe swallowing. Care at home at all costs—that may be rooted in love. It may also be rooted in pride or even foolishness. Honor can actually look like choosing a good facility, visiting often, advocating, overseeing care. Encourage the church to be involved, but don’t demand the church do the work at you avoiding it. I don’t remember what the other questions were. Smedly Yates: That’s all right. We got one minute left, Jake. Would you close our time in prayer? Closing Prayer Jacob Hantla: God, thank you for your word and just how replete it is with wisdom and principles and instruction and most of all revelation of who you are and what pleases you. God, I pray from this and just from this lesson and all the trials that you bring us through related to dementia and so many others that you would increasingly form us each individually and then corporately as your body. Form us into your image. Increase our godliness and then, God, bring us safely home. We love you. Be glorified in our lives and in our church. In Jesus’ name we pray. Amen. The post Equipping Hour: Dementia and the Christian Q&A appeared first on Grace Bible Church.

In this episode, I discuss panic attacks and underlying vulnerabilities that can increase the sensitivity of our alarm system. * What is a panic attack and what does it feel like? * What neurotransmitters are involved?* What is panic disorder?* What nutritional, genetic, and hormonal factors can be at play?* What types of inflammation and toxicity can lead to panic attacks?* How do the immune, limbic and autonomic nervous system contribute?* How does insecure attachment, trauma and stress interact with these other vulnerabilities?Takeaways* Panic attacks occur when the brain's alarm system is overly sensitive.* Physical symptoms of panic attacks can be debilitating and terrifying.* Underlying physiological factors contribute to vulnerability to panic attacks.* Neurotransmitters like norepinephrine and GABA play crucial roles in panic disorders.* Hormonal imbalances, especially in women, can increase the likelihood of panic attacks.* Mast cells are involved in the immune response and can trigger panic symptoms.* Biotoxins, such as mold toxins, can contribute to mast cell activation, limbic system dysfunction and autonomic nervous system dysfunction* Limbic system dysfunction can lead to heightened anxiety and panic.* The autonomic nervous system regulates our fight or flight response.* Emotional stressors and trauma can contribute to panic attacks, but appear to be aligning with other physiologic vulnerabilitiesChapters00:00 Understanding Panic Attacks03:07 Physiological Factors Behind Panic Attacks06:00 Neurotransmitters, Nutrient Levels and Panic Disorder08:52 The Role of Genetic Variants & Hormones in Panic Attacks12:07 Inflammation and Panic Attacks14:53 Mast Cells - The Bridge Between the Immune & Central Nervous Systems18:06 Biotoxins and Their Impact on Panic21:00 Limbic System Dysfunction and Panic24:11 The Autonomic Nervous System's Role26:45 Emotional Stressors and Panic AttacksAs always, I welcome any comments and questions. Your interests and what you care about helps guide the information I share. Also, its really nice for me to be in conversation and learning from you.Until next time,CourtneyTo learn more about my discovery calls, non-patient consultations, or mentoring, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

L'alimentation peut jouer un rôle. Pas forcément comme cause unique, mais comme facteur qui peut déclencher, aggraver ou entretenir l'anxiété.D'abord, il faut comprendre une chose : le cerveau n'est pas “déconnecté” du reste du corps. Il vit dans un environnement biologique. Et cet environnement dépend en partie de l'alimentation. Ce que vous mangez influence l'inflammation, le microbiote intestinal, les hormones, la production de neurotransmetteurs… et donc, indirectement, votre niveau d'anxiété.Premier point : la qualité globale de l'alimentation. De nombreuses études observent qu'un régime équilibré, riche en fruits, légumes, fibres, poissons et bonnes graisses, est associé à moins de symptômes anxieux. Par exemple, une revue systématique s'intéressant aux liens entre qualité alimentaire et santé mentale chez les étudiants conclut qu'une meilleure qualité de régime est fréquemment associée à une diminution de l'anxiété et du stress.Deuxième point : le grand suspect moderne, ce sont les aliments ultra-transformés. On parle ici des produits industriels très transformés : snacks, biscuits, sodas, céréales très sucrées, plats préparés, etc. Une revue scientifique publiée en 2022 par Lane et ses collègues montre que la consommation d'aliments ultra-transformés est associée à un risque plus élevé de symptômes dépressifs et anxieux. Ce n'est pas une preuve absolue de causalité, mais c'est un signal très cohérent, surtout quand on sait que ces aliments sont souvent pauvres en fibres et micronutriments, riches en sucres rapides, en sel, en additifs… et qu'ils favorisent une inflammation chronique légère.Troisième point : l'axe intestin-cerveau. Ce n'est pas une image : l'intestin communique réellement avec le cerveau. Le microbiote intestinal influence la production de substances qui modulent l'inflammation et le stress. Une alimentation pauvre en fibres et riche en produits ultra-transformés peut déséquilibrer ce microbiote, et ce déséquilibre peut favoriser un terrain anxieux.Enfin, il y a la question des nutriments. Certaines carences peuvent amplifier l'anxiété : magnésium, vitamines du groupe B, fer, zinc… parce qu'ils participent à la fabrication et à la régulation des neurotransmetteurs comme la sérotonine ou le GABA.Et sur les interventions ? Il existe quelques données intéressantes. Une méta-analyse publiée dans JAMA Network Open montre que les oméga-3 pourraient réduire les symptômes d'anxiété dans certaines populations, même si les résultats restent hétérogènes.Conclusion : l'anxiété n'est pas “dans votre tête” au sens moral du terme. Elle a une base biologique, et l'alimentation peut en faire partie. Bien manger ne remplace pas une thérapie ou un traitement quand il le faut. Mais c'est un levier concret, quotidien, souvent sous-estimé… pour apaiser le mental. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

What really happens in your brain when you drink alcohol — and what are the long-term effects over a lifetime? In this episode of Health Matters, host Courtney Allison sits down with Dr. Hugh Cahill, a neurologist at NewYork-Presbyterian the One and Columbia, to break down the science behind alcohol's impact on brain health.They explore how alcohol affects neurotransmitters to create feelings of relaxation and euphoria, why it can impair memory, coordination, and judgment, and how even moderate drinking is linked to increase risk of brain shrinkage, vascular damage, mood disorders, and dementia. Dr. Cahill also explains the cumulative nature of alcohol's effects and shares practical, evidence-based ways to protect your brain as you age — highlighting the powerful role of exercise, cardiovascular health, nutrition, sleep, and reducing alcohol intake.Whether you're curious about Dry January, worried about memory and aging, or simply want to make informed choices about your health, this conversation offers clear, expert insight into how your habits today shape your brain tomorrow.Key Topics CoveredHow alcohol affects neurotransmitters (glutamate, GABA, dopamine, endorphins)Why alcohol causes relaxation, lowered inhibition, and impaired coordinationLong-term effects: brain atrophy, neuron loss, memory impairmentAlcohol as a neurotoxinLinks between alcohol and:Cumulative, lifelong impact of drinking—even at low to moderate levelsRole of exercise in promoting neurogenesis and brain resilienceImportance of cardiovascular health, vitamins (B1, B12), and metabolic healthLimited evidence that puzzles or brain games prevent cognitive declinePractical brain-health strategies:Takeaway MessageBrain health is shaped by long-term habits. Because alcohol's effects are cumulative and even moderate use is linked to structural and vascular brain changes, reducing intake — along with exercising and managing cardiovascular risk factors—can meaningfully protect cognitive function and quality of life as we age.Expert GuestDr. Hugh Cahill is an M.D./Ph.D.-trained general neurologist providing comprehensive care for patients with a broad range of neurological conditions at NewYork-Presbyterian and Columbia. Dr. Cahill sees individuals with headaches, seizures, strokes, numbness, weakness, memory changes, and other common neurological concerns. Dr. Cahill as both a clinician and scientist supports an evidence-based approach to diagnosis and treatment, with an emphasis on careful evaluation and clear communication. For more health and wellness news, visit NewYork-Presbyterian's Health Matters website. 

TJ continued his conversation about ICE, and what Bernalillo District Attorney Sam Bregman said about them. Then as Gaba brought up, the benefits of being a cannibal, definitely steers to a really weird conversation. Plus an email bag. All this and more on News Radio KKOB See omnystudio.com/listener for privacy information.

The Luminescence Podcast, hosted by Schuyler Grant, powered by Commune. A space for science-based, culturally curious, and politically fearless conversations illuminating women's health. Ever wonder why your sex drive vanishes, your brain turns to mush, or you want to rage-quit your entire life for no reason? Blame your hormones, or, more specifically, how estrogen and progesterone run your brain. In this episode, Schuyler Grant and her expert panel (Dr. Jolene Brighten, Dr. Marisa Snyder, and Rosie Acosta) break down why it can feel like your brain is actively betraying you, particularly in perimenopause. What you'll learn: Estrogen and progesterone are brain hormones (not just “lady parts” hormones) The hypothalamic-pituitary-ovarian (HPO) axis explained in plain language Why perimenopause brings brain fog, mood swings, anxiety, and vanishing libido The menstrual cycle phases and how hormones shift throughout What's happening to your serotonin, dopamine, and GABA levels Why 80% of perimenopause symptoms happen in your brain A simple breathing technique to calm your nervous system Here's the thing: for decades, doctors thought women's hormones only affected reproduction. Turns out, estrogen and progesterone control your brain, bones, heart, metabolism, gut health, and basically everything. When they start declining in your mid-to-late thirties, your brain goes through a massive remodeling. No wonder you feel like you're losing your mind. This episode helps you understand what's actually happening and how to take back control. Podcast Partners: LMNTGet a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at DrinkLMNT.com/TLP Timeline: Go to  Timeline.com/LUMI and get 30% your first order with code ONECOMMUNE30

I have been away from podcasting for a while, and this mix is long overdue. I am kicking off 2026 by returning with a joyful vibe, designed specifically for your listening pleasure.This isn't just a playlist; it's a handwritten letter in the form of sound. Welcome to "From My Hands to Your Ears." MrTD presents: Joyful Expansions.Every track on this 41-song journey was chosen with intention. Think of it as a musical storyboard—a narrative built not with words, but with basslines, rhythms, and soul-stirring vocals.The story begins with a grounding affirmation from Jordi Cabrera, setting the stage for a deep dive into the essence of House. I've carefully pieced together a progression that moves through the spiritual highs of Chris Forman and Stephanie Cooke, the timeless energy of Kerri Chandler, and the intricate, jazzy landscapes of Glenn Underground. Each transition is a new chapter, designed to take you further into the vibe.This mix is a labor of love, a personal offering meant to be experienced from start to finish. It's a sanctuary I've built for you out of sound. So, tune in, trust the journey, and let this story wash over you.1. Jordi Cabrera, Bumi Thomas - I Am Soul2. Dark Horse, Soulfreakah, Faith Nakana - Envy3. Coflo -  We Gonna Make It4. Chris Forman feat. Jon pierce & Stephanie Cooke - It's In You5. E.O.L Leat Lisa Fischer - Soar6. Franck Roger, Shawn Chappelle, DJ Spinna - Enchanted7. Soulfreakah, Artwork Sounds - Africa Jesus8. El Bravo, Doug Gomez - I Speak Soul9. Playin 4 The City - Off Th Track10. Jay-J Feat. Latrice Barnett - Summertime11. Mishal Moore - Oh Lord12. Josh Milan - Starlight13. Visions Recordings - The Chromatic Universe EP PART TWO - 03 Stephane Attias - Live Life14. Ed Motta - Sus 4 Jam15. Earth People - Dance16. Alex Attias & Peven Everett - Love Dimension17. E.O.L - Hot Music18. Osibisa - Yo Luv Is Betta19. Charles Dockins - As We Dance20. Kerri Chandler - On My Way21. David Bailey, MissFly - You Don't Know22. BeBe Winans - Father In Heaven23. Nightmares On Wax feat. Mozez Ron Trent Vocal Remix - Citizen Kane24. Josh Milan - Fort Greene's Theme25. Inaya Day, DJ Spen, Soulfuledge, CoFlo - Ummah-Ye26. N'dinga Gaba feat. Scotty P. - Queen27. Kerri Chandler - Bar A Thym28. Dj Le Roi Ft Chappell - Get Ready29. Halo, Maiya, Atjazz - Glory30. D-Reflection feat Seth Sharp - Happiness Is Taking Over31. Gus Gus - VIP32. Melchior Sultana - Ghost33. Miguel Migs - Take Me To Paradise34. Kevin O - The 135. Melchyor A - Everyday36. Glenn Underground - A Soft Drink37. Karl Hancock Rux - Lamentations (You Son)38. Glenn Underground - Fuego De Sangre39. Gary's Gang - Makin Music40. The Jargons & Zulumafia - Sinday41. Alton Miller - Clouds Are Gone

If mental health were only about mindset, then food, sleep, and movement wouldn't matter. But anyone who's tried to “think their way out” of burnout knows that doesn't work.The body keeps score, whether we pay attention or not.Welcome to the Happy, Healthy, Strong Podcast — hosted by Adam Lane. This show breaks down what sustainable health actually looks like, through nutrition that supports the body, movement that feels intentional, and habits built to last without extremes.Episode HighlightsIn this episode, Adam Lane is joined by Stacey Caler for an honest, grounded conversation about what it really takes to support both mental and physical health. They explore why balance isn't about doing more, but doing the right things consistently. From protein intake and micronutrients to daily movement, sleep, and time outdoors, we connect the dots between physical inputs and mental clarity. We also address how goal-setting, accountability, and social media exposure can either support or undermine long-term well-being.Episode OutlineWhy mental health cannot be separated from physical health.The role of proper nutrition in mood, focus, and emotional regulation.How protein supports neurotransmitters like serotonin, dopamine, GABA, and glutamate.The importance of omega-3 fatty acids and micronutrient-dense foods.Why a protein-rich breakfast sets the tone for the entire day.Strength training and regular movement as non-negotiables for long-term health.Using data and tracking tools, including the Little Oak Strength app, to measure progress.Goal-setting without pressure and why consistency matters more than intensity.The impact of social media on mental health and the comparison trap.The gut–brain connection and how digestion influences mood.Daily routines that support mental health, including supplements and sleep habits.The underrated value of outdoor activity and short walks after mealsEpisode Chapters00:00 Intro00:26 New Year Banter & Big Goals02:30 Data-Driven Fitness & The “Committed Club”05:34 Holidays, Overindulging & Getting Back On Track12:31 Mental Health, Social Media & Post-Covid Withdrawal18:58 Neurotransmitters 101 & Why Protein Matters22:17 Practical Protein: Shakes, Meals & Sugar Cravings23:19 Building a Foundation: Food First, Then Supplements27:05 Morning Routine: Protein, B-Complex & Omega-3s30:54 Midday & Evening: Magnesium, Iron & Sleep Support36:35 Movement & Mood: One Workout, Different Person39:26 The 10-Minute Walk After Meals40:52 Sunlight, Fresh Air & Seasonal Mood45:56 Food, Supplements & Personal Responsibility49:13 Protein, Aging & Women's Challenges53:52 Find Your “Big Domino” (Sleep, Food, Exercise)57:20 Longevity, Function & Not “Dying While You're Living01:01:04 Listening, Trauma & Walking the Journey With Patients01:02:30 Menopause Teaser & Future EpisodeAction TakenPrioritize a protein-rich breakfast to support brain chemistry.Incorporate regular strength training and daily movement.Track goals and progress using simple, data-driven tools.Build consistent sleep routines to support recovery and mood.Spend time outdoors daily, even if it's just a short walk.Reduce unnecessary social media exposure when it negatively impacts mindsetConclusionMental and physical health are constantly influencing each other, whether that connection is acknowledged or not. What gets eaten, how the body moves, how well sleep is protected, and how often the nervous system gets a break all shape how someone feels day to day. Small, consistent choices create stability over time, and that stability is what makes long-term health sustainable, not extremes, pressure, or perfection.CTAIf this conversation resonated, subscribe to the Happy, Healthy, Strong Podcast and share this episode with someone who's working on building better habits without extremes.

In this episode, I sit down with Laurie Hammer, a functional nutrition therapist, to explore the powerful connection between brain health and gut function. Laurie shares her personal journey into functional nutrition and explains why amino acids play a foundational role in both emotional resilience and physical well-being. Our conversation dives into the relationship between neurotransmitters and amino acids, with a focus on serotonin, GABA, and catecholamines. Laurie explains how imbalances in these systems can contribute to anxiety, depression, and even neurodegenerative conditions. Through clinical experience and real-world examples, she outlines how targeted amino acid therapy can create meaningful changes when applied thoughtfully and individually. We also expand the discussion beyond supplementation to the lifestyle factors that support optimal brain health. From adequate protein intake and environmental toxin reduction to grounding practices and cleaner personal care products, this episode offers a holistic framework for supporting the nervous system. It is an insightful conversation for anyone interested in practical, nutrition-driven strategies to improve brain health and long-term vitality.   Key takeaways: Amino acids are crucial for neurotransmitter balance, impacting mental health and overall well-being. Laurie Hammer emphasizes the therapeutic potential of tryptophan, glutamine, and the role of other essential amino acids in addressing brain and gut health. Lifestyle changes, including nutrient-rich diets, sunlight exposure, and grounding, are essential for maintaining optimal neurological health. Targeted, therapeutic supplementation of amino acids can significantly improve symptoms of anxiety and depression by nourishing the nervous system. Laurie Hammer's approach encourages tackling brain health through foundational elements like proteins, fats, and minerals, rather than solely focusing on genetic predispositions.   More About Laurie Hammer:   Laurie Hammer is a Functional Nutritional Therapist, speaker, and host of the Take Back My Brain Podcast. She specializes in targeted amino acid therapy and brain-first nutrition to help women—and the practitioners who serve them—overcome anxiety, overwhelm, brain fog, and burnout without relying on medications. Laurie is the creator of the Mind Thrive Amino Acid Therapy Certification and is known for her bold message: You can't medicate away a nutrient deficiency.   Website Instagram Facebook Connect with me! Website Instagram Facebook YouTube

Video https://youtu.be/HBsku5G_SDMIn this whiteboard episode, we revisit the basal ganglia's simultaneous "go" and "no-go" pathways, dissecting how excitatory cortical inputs converge on the dorsal striatum's medium spiny neurons, with dopamine from the substantia nigra pars compacta amplifying reward/value while relays (globus pallidus externa/subthalamic nucleus) and outputs (globus pallidus interna/reticulata) fine-tune thalamic drive for action or suppression. Using OCD as an extreme case, we illustrate how enlarged synaptic spines and morphology from repetitive firing hijack the cortico-striato-thalamic loop, prioritizing compulsive habits over flexibility—revealing the circuit's indifference to judgment, driven purely by strengthened connections that conserve energy and dominate behavior in autism and beyond.Daylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 Basal Ganglia Review Recap of go/no-go pathways; five subcortical areas orchestrate all non-reflex movements simultaneously00:55 Nuclei Breakdown Inputs: caudate/putamen (dorsal striatum); relays: globus pallidus externa, subthalamic nucleus; outputs: globus pallidus interna, substantia nigra reticulata (GABA)02:54 Modulator Role Substantia nigra pars compacta (dopamine D1 excitatory/D2 inhibitory) amplifies value/reward; intensifies signals ("worth doing" or "avoid")05:40 OCD as Extreme Example OCD hijacks cortico-striato-thalamic loop; repetitive compulsions (e.g., light switch flipping) driven by strengthened synaptic connections06:03 Synaptic Morphology Repeated firing enlarges spines/connections (morphology/plasticity); larger synapses gain preference, dominating behavior07:23 Basal Ganglia Mechanics Cortex instructs (e.g., "flip switch") but cannot execute; dorsal striatum recruits basal ganglia to carry out/suppress actions09:58 No-Go Suppression Indirect pathway suppresses alternatives; go pathway executes specific movement; loop provides satisfaction in OCD11:25 Input Areas Indifference Dorsal striatum cells "dumb"—merely respond to inputs without judgment; value/reward from external modulators (dopamine, ACC)13:32 CNS Response Nature Brain/central nervous system prioritizes response over deliberation; habits dominate to conserve energyX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Getting into to it all, TJ covers everything from his Weekly World News roundup, to the interim Police Chief possibly being hired full time. Gaba adds the best and worst airlines, Jack Smith, and Sam Bregman on ICE. Lastly Chief Meteorologist Byron Morton on some harsh weather coming our way. All this and more on News Radio KKOBSee omnystudio.com/listener for privacy information.

Why do so many people with depression struggle to stop their antidepressants? What if the answer isn't about willpower — but about missing nutrients your brain needs to function?  Dr. James Greenblatt has spent 30 years in inpatient psychiatry. He watched patients go from one medication to two, then three, then five. Suicide rates kept climbing. And he started asking: What if the brain is simply missing what it needs? His new book Finally Hopeful explores the biological causes of depression most doctors never test for. Get the full episode breakdown at Biology of Trauma® Podcast - Episode 156: Can't Get Off Antidepressants? Ask for These Lab Tests In This Episode You'll Learn: [04:09] Why Dr. Greenblatt wrote Finally Hopeful after 30 years in psychiatry [12:50] Vitamin D as the foundation: Why nothing else works without it — not meds, not therapy [14:35] How vitamin D deficiency affects serotonin production in the brain [12:50] Dr. Aimie's personal story: vitamin D levels of 12, then only 20 with supplementation [17:06] Why vitamin D deficiency is one of the most common factors in people who can't stop antidepressants [18:48] The gut-serotonin connection: 90-95% of serotonin is made in the gut [21:00] The building blocks your brain needs: iron, B12, folate, zinc, magnesium [24:57] Brain inflammation and its connection to suicide risk [26:14] Why sleep deprivation creates inflammatory markers within hours [32:07] The simple labs to ask your doctor about — and why testing is the only path forward Resources/Guides: Free Guide: Top 3 Biochemical Imbalances That Affect Mood - a starting point for understanding the most common nutrient imbalances connected to depression The Biology of Trauma book - Available now everywhere books are sold. Get your copy Foundational Journey - The 6-week program to create inner safety and shift your nervous system. Build the foundation that allows your body to actually use the nutrients and support you give it. Dr. James Greenblatt - Get a copy of the Finally Hopeful book and find more resources at https://www.jamesgreenblattmd.com/ Related Podcast Episodes: Episode 41: Solutions for Low Serotonin and GABA in Trauma with Trudy Scott Episode 101: Brain Inflammation: Addressing The Overlooked Gatekeeper To Trauma Release with Dr. Austin Perlmutter

When fatigue lingers, it can be a sign that the body's ability to produce energy isn't functioning the way it should. Could that be what's happening in your case?. In this episode, I'm joined by Dr. Scott Sherr to explain why energy dysfunction is so common in chronic illness, and how methylene blue is being used clinically to support mitochondrial function, oxidative stress balance, and detoxification.I also explain why this topic is especially relevant for people with thyroid and autoimmune conditions, based on what I see regularly in practice. We finish by discussing nervous system regulation, GABA support, and why calming the stress response is often necessary before energy can truly improve.If you've been feeling worn down despite “doing all the right things,” this episode will help you think differently about what your body may actually need.Episode Timeline: 00:02 – Episode Introduction01:43 – Dr. Scott's Background06:26 – When Hyperbaric Helps08:59 – Hyperbaric and Chronic Illness12:51 – What Is Methylene Blue13:10 – Why Methylene Blue Helps18:04 – Why Energy Breaks Down19:09 – Detox and Antioxidant Support23:09 – Antimicrobial Effects Explained26:59 – Acute vs Chronic Dosing29:20 – Methylene Blue for UTIs32:04 – Safety and Side Effects37:33 – Thyroid and Autoimmune Support38:55 – Energy Changes in Thyroid Patients41:54 – Who Should Not Use42:16 – Product Quality Differences51:55 – Understanding the GABA System52:41 – GABA, Anxiety, and Sleep59:49 – When GABA Support Helps1:03:06 – Final Thoughts and ResourcesAbout Dr. Scott Sherr: Is a Board-Certified Internal Medicine Physician certified to Practice Health Optimization Medicine (HOMe) and a Hyperbaric Oxygen Therapy (HBOT) specialist. His clinical practice is built on HOMe as its foundation, complemented by an integrative approach to hyperbaric oxygen therapy that incorporates cutting-edge and dynamic HBOT protocols, comprehensive laboratory testing (utilizing the HOMe framework), targeted supplementation, personalized practices, synergistic technologies (both new and ancient), and more.Connect with Dr. Scott Sherr: Dr. Scott Sherr's Personal Website - https://drscottsherr.com/ Instagram - https://www.instagram.com/drscottsherr/ Transcriptions  Website - https://www.instagram.com/troscriptionsInstagram - To learn more about the Hyperthyroid Healing Diet Challenge visit Savemythyroid.com/challenge2026  Free resources for your thyroid healthGet your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.comHigh-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' s Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid?Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles Watch Dr. Eric's YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos Join Dr. Eric's Graves' disease and Hashimoto's group: https://www.facebook.com/groups/saveyourthyroid Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308 Read all of Dr. Eric's published books: http://savemythyroid.com/thyroidbooks Work with Dr. Eric: https://savemythyroid.com/work-with-dr-eric/

In the second part of this series, Dr. Neishay Ayub discusses levetiracetam and one of its most common side effects, irritability.  Show citations:  Abou-Khalil B. Levetiracetam in the treatment of epilepsy. Neuropsychiatr Dis Treat. 2008;4(3):507-523. doi:10.2147/ndt.s2937  Löscher W, Gillard M, Sands ZA, Kaminski RM, Klitgaard H. Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond. CNS Drugs. 2016;30(11):1055-1077. doi:10.1007/s40263-016-0384-x Rogawski MA. Brivaracetam: a rational drug discovery success story. Br J Pharmacol. 2008;154(8):1555-1557. doi:10.1038/bjp.2008.221 Ulloa CM, Towfigh A, Safdieh J. Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures. Neuropsychiatr Dis Treat. 2009;5:467-476. doi:10.2147/ndt.s4844 Wu PP, Cao BR, Tian FY, Gao ZB. Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil. Neurosci Bull. 2024;40(5):594-608. doi:10.1007/s12264-023-01138-2 Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine. A Randomized Double Blind Controlled Study. Pediatr Neurol. 2021;119:15-21. doi:10.1016/j.pediatrneurol.2021.02.010 Major P, Greenberg E, Khan A, Thiele EA. Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results. Epilepsy Behav. 2008;13(3):557-559. doi:10.1016/j.yebeh.2008.07.004 Romoli M, Perucca E, Sen A. Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review. Epilepsy Behav. 2020;103(Pt A):106861. doi:10.1016/j.yebeh.2019.106861 Show transcript:  Dr. Neishay Ayub: Hello, my name is Neishay Ayub, and today we will be discussing levetiracetam and one of its most common side effects, irritability. While levetiracetam can be remarkably helpful for patients, behavioral adverse effects were noted in post-marketing analysis and open-label studies in adult and pediatric patients. For this, physicians started using vitamin B6 supplementation, particularly in the pediatric populations. Why would physicians use B6? Well, low vitamin B6 has been associated with neuropsychiatric disorders, which could be related to the fact that vitamin B6 is an essential co-factor for several neurotransmitters that affect mood and behavior, such as serotonin, dopamine, and GABA. There is an epilepsy syndrome associated with vitamin B6 deficiency. And vitamin B6 deficiency is seen with enzyme-inducing anti-seizure medications, although levetiracetam is not an enzyme-inducing seizure medication. These are some of the possibilities as to why vitamin B6 supplementation was initially explored. Some initial anecdotal evidence and case reports were suggested that it was helpful in reducing behavioral side effects and the need to discontinue levetiracetam. There was a meta-analysis reviewing pyridoxine use, which included 11 case reports and retrospective studies, as well as one prospective study, case-control study, which was not placebo controlled. While evidence was suggestive of a benefit, the quality of the evidence was poor due to selection, reporting, and assessment biases. Overall, the authors recommended a larger randomized, controlled, double-blind trial with adequate statistical power, well-defined eligibility criteria and standardized assessment tools to evaluate B6 efficacy in treating levetiracetam-induced irritability. Since then, there was one small randomized, controlled, double-blind study involving 105 children for whom neuropsychiatric adverse effects were noted after levetiracetam was introduced. Children were randomized to receive a therapeutic dose of pyridoxine, which was 10 to 15 milligrams per kilogram per day, up to 200 milligrams, or a homeopathic dose of 0.5 milligrams per kilogram per day. They were scored on a behavioral checklist and monitored for up to six months. While there was a reduction in behavioral symptoms reported in the therapeutic pyridoxine group, there was no validated assessment tools used, and there was an absence of a true placebo group. Lastly, there are a few studies reporting on adverse effects of B6 toxicity, which is possible, but it's typically seen at higher daily doses, although something to keep in mind if considering B6 supplementation. In summary, while there has been a clinical practice of prescribing pyridoxine at 50 to 100 milligrams as a low-cost, well-tolerated adjunctive supplement, there may be a modest benefit for some patients, but the overall efficacy for the treatment of neuropsychiatric side effects for levetiracetam remain unclear, and more evidence is needed. 

The gut-brain connection is deeper, weirder, and far more literal than we ever imagined. For years, we've been told that our 'gut feeling' is just a metaphor for intuition. But recent science suggests that your gut is actually a 'second brain'—a complex neural network of 100 million neurons that can operate entirely on its own, independent of the one in your skull.We aren't just talking about digestion; we're talking about a bidirectional superhighway where bacteria in your colon produce up to 90% of your body's serotonin and significantly influence your levels of GABA, the primary neurotransmitter for calm. Essentially, the 'critters' in your gut might be the master puppeteers of your mood, your sleep, and even your cognitive clarity.But as the market for 'gut health' explodes, the gap between marketing claims and clinical reality is widening. I interview Gabe Dough, the founder of Good Bru. His product bridges that gap using a specific combination of prebiotics and a resilient probiotic strain known as BC30, which I've been using.2:16 “All illness starts in the gut”6:50 Origins of autoimmune disease11:40 Probiotic vs Prebiotic20:43 Synbiotic vs Psychobiotic25:55 The truth about Probiotic yogurt30:58 Probiotics for PCOS34:41 Gut microbiome testing42:25 Probiotics vs Candida44:06 Probiotics for protein absorption44:25 Probiotics for children46:39 Probiotics for Psoriasis47:14 Probiotics for bone loss54:32 Digestion hacks epic feasting58:57 Weird science: Personality transplant via gut microbes1:03:50 Weird science: Microbial hijacking of craving control1:06:53 Gabe's supplement stack1:09:03 Probiotic cofactors1:12:03 More yogurt hacks1:16:42 Weird science: Brain as "PR department" for the gut1:19:33 Stress vs the “gut brain”1:21:01 Gut health as a tool for architecting personalityRead

Can zinc genuinely improve sleep—or is it just another supplement riding good marketing? In this Mini Mikkipedia episode, Mikki unpacks what the research actually shows about zinc and sleep, with a specific lens on midlife women and endurance athletes. She walks through the proposed mechanisms—GABA-A receptor modulation, neurotransmitter balance, melatonin synthesis, and circadian rhythm regulation—before cutting to the critical point: zinc only appears to improve sleep when it corrects a deficiency. Drawing on a 2024 systematic review of randomised trials, Mikki explains why benefits show up in populations like older adults, shift workers, and clinical patients, but not in well-nourished athletes using ZMA. The episode also covers zinc deficiency risk factors, menopause-specific considerations, copper–zinc balance, testing strategies, and practical dosing guidance—so listeners can make evidence-based decisions rather than chasing “super sleep” promises.Key Topics CoveredHow zinc influences sleep physiology (GABA, melatonin, circadian genes)What human trials actually show about zinc supplementation and sleepWhy ZMA fails in well-nourished athletesZinc deficiency risk in athletes and midlife womenCopper–zinc ratio, testing, and safe supplementation guidelines Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order

Hot flashes, brain fog, anxious nights, and a doctor telling you it's “just stress” can make you feel powerless. We start the year by taking that power back. I sit down with Dr. Sarah Doyle—doctor of physical therapy and functional medicine practitioner—to map the real mechanics of midlife: how estrogen fuels brain energy and vessel health, why progesterone calms the nervous system, and how chronic stress diverts raw materials away from the hormones that stabilize mood, sleep, libido, and cognition.We dig into the surprising overlap between postpartum and perimenopause—both are hormone crashes that scramble serotonin, GABA, and dopamine. You'll hear why ignoring “small” clues like night sweats, frozen shoulder, recurrent UTIs, or new-onset anxiety can snowball into bigger issues if you don't address root causes. Dr. Doyle breaks down adrenals and cortisol in plain language, showing how fight-or-flight can stall sex hormone production, raise cardiovascular risk, and accelerate musculoskeletal pain. We also talk candidly about racial disparities in symptom duration, the genitourinary syndrome of menopause, and the life-changing role of local estrogen for tissue health and comfort.BioDr. Sarah Doyle is a former ICU physical therapist turned Functional Medicine clinician and Diplomate of the American Clinical Board of Nutrition who specializes in hormone optimization and disease prevention through evidence-based nutrition. After years of publishing research, writing bestselling books (The THIN Formula and 7X Method), co-founding HealWell Regenerative Institute at the prestigious Carillon Wellness Resort, and working as a performance physiotherapist for artists like Shakira and The Weeknd, Dr. Doyle identified a major gap in women's hormone care—especially during perimenopause and menopause. She created her new menopause supplement to be as strong as HRT under the Vita-Fem brand: a potent, all-natural, research-backed daily stick pack designed to reduce brain fog, balance hormones, and improve compliance by dissolving easily in water. Proven through before-and-after testing and published case studies, this innovative formula reflects Dr. Doyle's mission to help millions of women thrive through their “second puberty” and beyond—without reliance on pharmaceuticals. 15 min. Free Consultation -https://vita-fem.com/Website - https://drsarahdoyle.comSocial MediaInstagram @Vita_Fem_SupplementsTikTok @Vita_FemClick here to order Vita-FemThank you for listening to the V.I.B.E. Living Podcast. If this episode resonated, please like, subscribe, and share it with a woman stepping into her next chapter. V.I.B.E. represents who you're meant to be — Vibrant, Intuitive, Beautiful, and Empowered — and awakening is the journey back to yourself through awareness, community, and intentional self-care. Stay connected with Lynnis and explore the V.I.B.E. Living world:

Video Link: https://www.youtube.com/watch?v=FA1QdeuGhJEIn this whiteboard-style episode, we dive deep into the auditory brainstem response (ABR) and its profound implications for the autistic phenotype, tracing sound from the cochlea's powerful endocochlear potential through multi-step brainstem relays to the thalamus and auditory cortex. Highlighting high excitation paired with low inhibition, we map how poor filtering at key stations—like the superior olivary complex, lemniscus, and inferior colliculus—leads to listening dissonance, where sounds blend uncontrollably into overwhelming noise. The discussion underscores the mesencephalon's critical role in sensory gating, binaural processing, and the tragic risks of overload, emphasizing why compromised inhibition cascades into sensory chaos and the urgent need for understanding these upstream mechanisms.Daylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 auditory processing episode: low inhibition + high excitation = sensory overload; mesencephalon key for hearing, vision, motor in autism00:55 ABR & Mesencephalon Focus Review prior ABR episode (wave 5 emphasis); mesencephalon central for toxicity phenotype sensory issues01:17 Brainstem Anatomy Slices Sliced brainstem views: medulla, pons (football shape), small mesencephalon, thalamus/subcortical above02:17 Hearing vs. Vision Pathways Hearing multi-step (cochlea → brainstem → thalamus); vision faster (retina → lateral geniculate/superior colliculus)03:21 Cochlea & Endocochlear Potential Spiral cochlea powers hearing; highest DC voltage (endocochlear potential ~+85-100mV) via potassium gradient; melanin underrated07:56 ABR Waves 2-7 Breakdown Wave 2: exiting cochlea; 3: cochlear nuclei sync; 3-4: superior olivary/lemniscus (ITD/ILD binaural, glycine/GABA inhibition); 5: inferior colliculus; 6-7: medial geniculate to A1 cortex14:17 Inferior Colliculus Role Glutamatergic excitation; binaural convergence; gamma needed for suppression (challenging in autism)17:01 Thalamus Entry & TRN Gating Wave 6: subcortical/thalamus; TRN (GABA sectors) filters sensory; compromised in autism risks overload23:20 Listening Dissonance Intro Sounds blending issue in autism; starts at olivary/lemniscus due to poor inhibition; firehose-like overload35:59 Signal-to-Noise & Prefrontal Effort High excitation/low inhibition = noise dominance; recruits medial prefrontal/ACC/insula for top-down control40:50 Overwhelm Consequences Hijacked emotional circuits (amygdala, insula); leads to shutdown/elopement; avoid talking when overwhelmed.X: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Alprazolam is a short-acting benzodiazepine that enhances the inhibitory effects of gamma-aminobutyric acid (GABA) at the GABA-A receptor. Clinically, this results in anxiolytic, sedative, muscle-relaxant, and anticonvulsant effects. After oral administration, alprazolam is rapidly absorbed, with onset of action typically within 30–60 minutes. It undergoes extensive hepatic metabolism primarily via CYP3A4 to inactive metabolites, and has an elimination half-life of approximately 11 hours, which may be prolonged in elderly patients or those with hepatic impairment. Common adverse effects include sedation, dizziness, impaired coordination, and cognitive slowing. More serious risks include respiratory depression, especially when combined with opioids, alcohol, or other CNS depressants. Clinically, alprazolam should be used at the lowest effective dose for the shortest possible duration. Abrupt discontinuation should be avoided; gradual tapering is essential to reduce withdrawal risk. It is a controlled substance that carries the risk of addiction and dependence. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Could you discuss GABA for insomnia and sleep support?  Are there long-term health benefits?What impact does a cocktail of pharmaceutical drugs have on the microbiome?Can I take more than 2 daily doses of Dr. Ohira's probiotics?Which is the correct estrogen to take in HRT?  Estriol or estradiol?In light of the recent EPA proposal to double permissible formaldehyde emissions, how does this jibe with MAHA?

Top stories of 2025Does the use of statins lead to muscle loss?I have mitral valve prolapse with regurgitation. Should I increase my supplement dosages?

Most of us don't realize how much alcohol affects our bodies until we take a break. In this first episode of Office Hours, I break down what really happens when you give up alcohol for 30 days. Alcohol impacts nearly every system—from your brain and hormones to your gut, liver, and immune system—but the good news is your body begins repairing itself far faster than most people expect. I discuss: • What alcohol really is—and why the “buzz” is actually your brain slowing down• How alcohol affects neurotransmitters like GABA, dopamine, and glutamate• Why even moderate drinking disrupts sleep, mood, hormones, and metabolism• How alcohol impacts the liver, gut microbiome, immune system, and cancer risk• Why hangovers feel like the flu—and what's actually happening in your body• What happens when you stop drinking, week by week, from detox to deep repair• The surprising benefits to energy, focus, skin, sleep, and emotional resilience• Practical tools to manage cravings, social pressure, and sleep disruption• Why community support makes behavior change easier and more sustainable Your body has an incredible ability to heal and often, it just needs you to take your foot off the gas. Try it for 30 days. You may be amazed by how different you feel. If you want extra support, join us for the Hive January Challenge, where we'll guide you through the process, track progress, and share experiences together. Visit functionhealth.com for 160+ lab tests at just $365 a year. Helpful Resources: Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive Have a question you'd love answered on the podcast? Submit it here

Struggling with weight loss and stubborn belly fat despite a healthy diet and exercise? Discover the best bedtime drink for weight loss to help break a weight loss plateau and lose belly fat faster.

In this conversation, Cheryl McColgan discusses the significance of establishing a wind down routine before bed to enhance sleep quality. She emphasizes the importance of calming activities, such as reading, warm baths, and reducing screen time, to prepare the body and mind for sleep. Cheryl also touches on the use of sleep supplements and tools to improve sleep, highlighting the critical role of good sleep in overall health and wellness. Takeaways Create a simple wind down cue before bed.Calm your brain and nervous system for better sleep.Screen time at night is a poor habit for sleep.Reading before bed can help you relax.Warm baths signal your body to calm down.Turning off bright lights aids in winding down.Sleep is critical for health and longevity.Good sleep supports weight loss and fat loss.Consider a warm drink as part of your bedtime routine.Engage with others about effective wind down routines. Disclaimer: Links may contain affiliate links, which means we may get paid a commission at no additional cost to you if you purchase through this page. Read our full disclosure here. CONNECT WITH CHERYL Shop all my healthy lifestyle favorites, lots of discounts! 21 Day Fat Loss Kickstart: Make Keto Easy, Take Diet Breaks and Still Lose Weight Dry Farm Wines, extra bottle for a penny Drinking Ketones Wild Pastures, Clean Meat to Your Doorstep 20% off for life Clean Beauty 20% off first order DIY Lashes 10% off NIRA at Home Laser for Wrinkles 10% off or current promo with code HealNourishGrow Instagram for daily stories with recipes, what I eat in a day and what’s going on in life Facebook YouTube Pinterest TikTok Amazon Store The Shoe Fairy Competition Gear Getting Started with Keto Resources The Complete Beginners Guide to Keto Getting Started with Keto Podcast Episode Getting Started with Keto Resource Guide Episode Transcript Cheryl McColgan (00:00.078)Hey everyone, I’m Cheryl McColgan, founder of HealNurshGrow and welcome to day four of your healthy habits challenge. Today’s habit is very simple, but it’s so powerful and it has to do with one of the things that I think is one of the most underappreciated aspects of health and that is sleep. And so the habit that we’re going to do today is to create a simple wind down cue before bed. So what this does is basically gets you ready for sleep, starts to calm your brain, starts to calm your nervous system so that you can actually get in bed and go to sleep instead of getting in bed and staying wired for multiple minutes or even hours after that. Definitely something we want to avoid. So having this consistent wind down cue is exactly what it does. Cues your brain and your body to be ready for sleep and to start to calm down. There’s any number of things that this could possibly be for you. One of the things that you will have heard from many people in the past, and this is so true, is that screen time at night is really a poor habit to have to get good sleep. So maybe your wind down cue is putting your phone in the other room and putting it on the charger before you get ready for bed. That’s a great way to do that. It also cuts down on the blue light. So that will allow your body to produce melatonin, which gives you better sleep. But this cue is something you want to do consistently every day, just so that it gives again, your brain and your body that idea that it’s time to calm down. Another thing that people really like doing for this type of cue is to simply do some reading before bed. And so again, not reading on a device like your computer or your phone, but maybe an old school book. I know that sounds crazy or the the Kindles now have, they don’t have any blue light coming off of them. And just reading is just very calming in the evening. It’ll put you right to sleep. Even books that you’re in love with and excited about. Sometimes it’s like, it just starts to get you very drowsy and you want to ideally do it in bed. as soon as you really start to get sleepy, you just put the book aside and go to sleep. Cheryl McColgan (02:16.782)Another one that’s great for bedtime is a warm bath. The whole reason that this works is warming up your body. And ideally you want to do it maybe an hour to an hour and a half before bed. But again, it’s a relaxing activity. It’s something that signals it’s time to calm down and get ready for sleep. But it also has a physiological response in the body where you warm up your body temperature a little bit. Then when you get out and it starts to come back down, your body temperature coming back down actually makes you sleepy. So that’s another good one. But really any of these, can be anything that works for you. You just want it to be something that you can do on a consistent basis and that actually helps calm your nervous system. So it could also be, you know, a breathing exercise or some light stretching or, you know, anything like that, that’s going to make going to bed easier for your body. Another one is, Turning off bright lights. So maybe your cue for your wind down is to go around your house and turn off all the lights and maybe you just have like a gentle Red light in the room or just dim lights in your room as you’re winding down But just doing those cues time after time eventually it gets your body to a place where It’s calm enough and it’s ready some other things that I use for sleep since we’re talking about sleep sometimes just a wind down cue is not enough for some people but Again, I think if you practice it on a consistent basis, that’s going to change over time where it really does help you get to sleep. But there’s other things. There’s supplements you can take. mentioned melatonin. I actually wouldn’t recommend taking that on a regular basis because it does tend to make you feel groggy in the morning. In addition to that, it can also affect your own melatonin production over time. So that’s kind of not as recommended. But there’s plenty of sleep supplements. Sorry, I was losing my word there. Sleep supplements out there. that I’ve tried, I’ve used a brand called Dream. I had a new one sent to me that was from, the company’s escaping me. It’s kind of a funny name, but I’ll link it in the show notes. So also that could be part of your ritual is if it’s both of these drinks are kind of like a hot cocoa that you drink at night that has magnesium, GABA, some other sleep inducing things in it. So that could be your ritual is to make your nice warm drink, go get in your bed, sit that, relax, and then. Cheryl McColgan (04:38.434)go to sleep. So that’s one of the tools that I tend to use a lot. And then I’ve also talked a lot about in the past that I use a bed cooling pad. So I’m menopausal age, unfortunately. And a few years ago, I started getting horrible night sweats where it just really interrupted my sleep. So I started using a cooling pad on my bed about five years ago. And now it is so hard for me to sleep without it because it actually not only cools you but warms you as well. and can use it to like gently warm the bed as your, almost as your alarm clock. Instead of using a harsh alarm, it just starts to warm up your body and wake you up very naturally. So depending on where you are with sleep, this wind down cue is a great start. And that’s all we’re looking for in this challenge, right? Just trying some new little habit snacks that you can see if it works for you or you can see if it would do you good to add it on in the future. But this is just the beginning. So sleep is such, like I said, such a critical and underappreciated thing for health, longevity, for weight loss even, helps with fat loss. I mean, there’s so many reasons why you want to get good sleep, but this is just a small way that you can get started. Start repeating this if it speaks to you. If you’re someone that has trouble with sleep, I highly recommend that you take this one on and keep it for the rest of the challenge and beyond, because it will only help you. It may not be enough, like I said, but it is great stars. So some of those things that I mentioned, I’ll make sure I link them in the show notes. But for now, just create your simple wind down cue before bed. Try it out, see how you sleep and let me know in the comments if this works for you. If you already have a wind down routine, I’d love to hear about it because I think everybody wants to hear some good ideas if they can’t think of anything that works for them or speaks to them. So definitely let me know if you have any tips and we can share them with everybody else in the comments. OK. See you again tomorrow.

What happens when your family stages an intervention because they've been avoiding you 10 days every month?I'm sharing the story of a patient who had a complete breakdown at Christmas dinner. She snapped at her husband, her kids, her mom, her in-laws—everyone. A few hours later, her family told her: "We love you, but for 10 days every month, we actively avoid you."She came to me asking: Am I bipolar? Am I manic? What's happening to me?This is PMDD premenstrual dysphoric disorder. And when it collides with perimenopause, it becomes a perfect storm. This is not just PMS. This isn't you being dramatic. It's a real biochemical thing happening in your brain an abnormal response to normal hormonal changes.I discuss the science of PMDD: how GABA receptors respond to progesterone metabolites, why some brains are change sensitive, and why the hormonal volatility of perimenopause (erratic estrogen, declining progesterone, unpredictable timing) makes everything exponentially worse. I explain treatment options from luteal-phase SSRIs to Yaz to Duavee for refractory cases, and why tracking your symptoms for at least two cycles is critical for diagnosis.Highlights:Why "I feel like I'm watching myself burn down my life and can't stop it" is the hallmark of PMDD.The DRSP tracking tool: why you need 2 cycles to diagnose PMDD properly.Why Vitex (chasteberry) might help mood swings and breast pain.What Duavee is and why it works for women who can't tolerate progestins.Why Dr. Tammy Rowan calls PMDD a progesterone sensitivity issue.Ulipristal: the emergency contraception drug being studied for PMDD.If you've ever felt like your brain gets hijacked on a schedule, if you've felt completely out of control, this episode is for you. Track your symptoms. Find a clinician who takes cyclic mood symptoms seriously. You don't have to live like this. Please share this episode with someone you know might be experiencing this or a clinician you think would benefit from it.Resource:DRSPDr. Tami RowenGet in Touch with Me:WebsiteInstagramYoutubeSubstackMentioned in this episode:GSM CollectiveThe GSM Collective - Chicago Boutique concierge gynecology practice Led by Dr. Sameena Rahman, specialist in sexual medicine & menopause Unrushed appointments in a beautiful, private setting Personalized care for women's health, hormones, and pelvic floor issues Multiple membership options available Ready for personalized women's healthcare? Visit our Chicago office today. GSM Collective

You're not weak, broken, or lacking discipline. If you keep reaching for food at the end of a long day, there's nothing wrong with you—there's something going on inside you. In this episode, we break down what's really happening in your brain and body when emotional eating shows up (especially in the evening), and why willpower alone isn't the answer.This isn't about blaming your cravings on “bad habits”—it's about understanding the biology behind them so you can finally stop fighting yourself and start supporting your nervous system instead.We'll cover what's actually happening with your dopamine and GABA levels, why your brain shifts into survival mode, and simple tools to regulate your body and create better routines that don't rely on food to soothe. No shame, no restriction—just science, compassion, and strategies that work in real life.What you'll learn:Why your brain turns to carbs, sugar, or wine in moments of overwhelmWhat's really driving emotional eating (hint: it's not hunger)The “brain battery” metaphor that explains your low-willpower momentsHow to use simple pattern interrupts, sensory shifts, and micro-boundariesWhy predictability = safety, and how to use that to rewire your habitsTools that take 30–90 seconds—but create powerful changeYou don't need more willpower. You need better tools—and the right kind of support.Support the showGet Weekly Health Tips: thrivehealthcoachllc.com Join the Thrive Collective Facebook group Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You!

Butyrate, produced by gut bacteria when they ferment dietary fiber, acts as a signaling molecule in the gut-brain axis, influencing stress, pain tolerance, immunity, and brain health Through multiple mechanisms, including specific enzyme inhibition and NF-κB pathway regulation, butyrate reduces neuroinflammation and protects against neurodegenerative conditions like Alzheimer's and Parkinson's disease Butyrate influences key neurotransmitters including GABA, serotonin, and dopamine, while also increasing brain-derived neurotrophic factor (BDNF), which supports neuronal growth and cognitive function The vagus nerve serves as a communication highway between the gut and the brain, transmitting signals about butyrate levels that affect mood regulation, stress response, and immune function Optimizing gut health through dietary fiber and homemade fermented foods helps promote butyrate production and maintain a healthy gut-brain connection

Vintage drug ads promised calm mornings, slimmer silhouettes, and instant relief from restless nights. We dig beneath the glossy slogans to unpack how Black Beauties, Quaaludes, Miltown, Barbiturates, and Purple Hearts shaped the path to today's mediations—and what that history teaches us about safety, dependence, and withdrawal. With clear explanations of GABA, tolerance, and cross‑tapering, we connect old “uppers and downers” to modern clinical practice and the real risks people still face.I share why amphetamines jumped from diet pills to productivity boosters, how tranquilizers won hearts and airwaves, and why barbiturates' direct receptor action made them both effective and uniquely lethal. We explore the strange logic of combining a stimulant with a sedative in a single pill, the concept of the therapeutic index that flipped prescribing habits, and the cultural pressure—often aimed at women—that fueled demand for daily sedation. You'll hear how benzos improved the safety margin, where they still go wrong, and how clinicians now use careful tapers, screen for polysubstance use, and apply harm‑reduction strategies to prevent overdose.If you've ever wondered why some drugs vanished and others became standard, this deep dive brings context, clarity, and practical takeaways. You'll walk away able to explain the difference between narrow and wide therapeutic indexes, why withdrawal from certain depressants is so dangerous, and how our field balances relief with risk. Subscribe, share with a colleague who treats anxiety or addiction, and leave a review with the one historical ad or insight that surprised you most.To contact Dr. Grover: ammadeasy@fastmail.com

In this episode, we're revisiting some of the most magical moments and scientific milestones of 2025 - including the incredible legacy of Dame Jane Goodall, the brain-wave reading bionic-knee, why labradors are so greedy, and the beer that doesn't give you a hangover... Like this podcast? Please help us by supporting the Naked Scientists