Podcasts about Gaba

Get Myo Relax and Calm by Myoscience (20% off, code auto applied): https://bit.ly/4oWU62X  Pre-order Keto Flex Revised and get free bonuses at: https://bit.ly/4wKG1sM    You can fast, do keto, count calories, and hit the gym, and still wake up stuck with the same belly fat. The reason is almost never your daytime effort. It is what happens after your head hits the pillow. Every night your body asks one question: is it safe to burn fat? About 70 percent of your fat burning growth hormone is released while you sleep, but only if insulin is low and your deep sleep is protected. In this lesson, Ben Azadi walks through the three bedtime habits, in the exact order your body wants them, to make the next 30 nights work for your fat loss instead of against it. Key takeaways: Insulin can stay elevated three to five hours after eating, blocking your overnight growth hormone pulse In a crossover trial, a 10 p.m. dinner reduced overnight fat burning and raised cortisol versus the identical 6 p.m. meal A Mayo Clinic trial showed four hours of sleep for two weeks added 11% more visceral fat, while the scale barely moved A cold (65 to 68°F), pitch dark room and a consistent sleep and wake schedule protect deep sleep Relaxation is chemistry: myo-inositol, magnesium glycinate, potassium glycinate, glycine, taurine, GABA, and L-theanine support it The three night challenge: no late snacks, a dark cool room, and track sleep, cravings, waist, and morning energy Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash -Get 15% off your next order at: https://getmte.com/dave Host Dave Asprey sits down with Jeff Boyd, founder and chairman of MTE (More Than Energy), the caffeine-free energy drink built around adaptogens, nootropics, and prebiotics that delivers what Boyd calls "energy that loves you back." Before launching MTE, Jeff spent 15 years as President and co-owner of Luggage Free, scaling the company to operations in over 100 countries before selling it in 2019. He brings the operational discipline of a veteran entrepreneur and the personal conviction of someone who built the energy product he actually wanted to exist. Dave and Jeff get into the full science and strategy behind MTE's ingredient stack, including paraxanthine, ashwagandha, eleuthero, maca, GABA, theanine, and saffron, and why each one was chosen for its role in stress response, brain optimization, and sleep optimization. They also dig into the formulation challenges of building a clean-label supplement over a stimulant base, the real difference between caffeine and its downstream metabolite paraxanthine, and why this blend functions more like a foundational biohacking protocol than a beverage. You'll Learn: Why conventional energy drinks wreck your cortisol curve and what to do instead How paraxanthine delivers the benefits of caffeine without the jitters or sleep disruption The adaptogen trio (ashwagandha, eleuthero, and maca) and how they work together for stress response and human performance Why saffron is one of the most underrated nootropics for mood and brain optimization How gut health and the microbiome connect directly to your energy, metabolism, and longevity The mitochondria connection between willpower, physical performance, and entrepreneurial output How AI is reshaping small teams and what founders need to do right now to stay competitive Why the cleanest path to anti-aging and longevity starts with how you manage your energy across the day Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Gatlan | Book your free consultation at www.gatlan.com/DAVE - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jeff Boyd, MTE, More Than Energy, caffeine-free energy, paraxanthine, adaptogens, ashwagandha, eleuthero, maca, nootropics, saffron, GABA, theanine, prebiotics, gut health, stress response, cortisol management, sleep optimization, huckleberry acai, clean label formulation, stevia Reb A, energy drink alternative, paraxanthine vs caffeine, afternoon energy, Luggage Free, cycling endurance, long jump training, ADHD entrepreneurship, AI small teams, willpower mitochondria Resources: • Get 15% off your next order at: https://getmte.com/dave • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:42 – What Is MTE? 03:50 – Ingredients Deep Dive 09:49 – Flavors & Formulation 12:31 – Dave's Caffeine Origin 18:35 – Athletic Identity 22:38 – ADHD & Entrepreneurship 26:43 – AI & Future of Work 30:47 – Willpower & Mitochondria 35:34 – MTE Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Naltrexone is often a first-line medication for AUD. It works as an opioid receptor antagonist, reducing the rewarding effects of alcohol and decreasing cravings. Patients frequently report that alcohol becomes less pleasurable while taking the medication. Oral naltrexone is typically dosed at 50 mg daily, while a long-acting injectable formulation is also available. Avoid use in patients taking opioids and use caution in significant liver dysfunction. Acamprosate helps maintain abstinence by modulating glutamate and GABA neurotransmission. Chronic alcohol use disrupts the balance between excitatory and inhibitory pathways in the brain, and acamprosate helps restore equilibrium. It is primarily eliminated renally, making it a useful option in patients with liver disease. The most common adverse effect is diarrhea. Disulfiram works through a completely different mechanism. It inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation when alcohol is consumed. This can lead to flushing, nausea, vomiting, headache, and hypotension. Because of this aversive reaction, patient motivation and adherence are critical for success. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Most people who say they've tried kava have tried a watered-down extract that feels like weak chamomile, then concluded the plant does nothing. Cameron George has spent years arguing that the real thing, whole-root and traditionally prepared, is one of the most misunderstood plant medicines on Earth. In this conversation Aubrey sits down with him for a full masterclass on what kava actually is, why the West got it so wrong, and how a South Pacific root that has anchored entire island civilizations for thousands of years might be the missing piece in the modern search for connection without self-betrayal.Kava occupies a strange category of its own. It relaxes without sedating, opens you emotionally without impairing you, and softens social armor without the crash, the fog, or the regret that follows alcohol. Cameron walks through the pharmacology behind that (the GABA upregulation, the dopaminergic support, the reverse-tolerance phenomenon where the plant becomes more effective with consistent use rather than less) and into the cultural story underneath it, including the poorly constructed studies from 1999 that nearly killed kava's reputation in the West right as it was set to break through. From there the conversation widens into nervous-system repair, the difference between borrowed relief and generative states, the role kava can play in psychedelic integration, and what it means to change your state without leaving yourself behind.Check out TRU KAVA and USE CODE AUBREY10 FOR 10% OFF►Website | https://trukava.com/►Instagram | https://www.instagram.com/trukava/This episode is sponsored by►Metal Mark Gold Aurum Collectable Art |  ⁠https://mtlmrk.com/⁠►Korrect Life | ⁠https://korrectlife.com/| Aubrey Marcus |►Website | ⁠⁠https://www.aubreymarcus.com/►Instagram | https://www.instagram.com/aubreymarcus►Facebook |⁠⁠ https://www.facebook.com/AubreyMarcus/►X |⁠ https://x.com/aubreymarcus►Substack: https://www.aubreymarcus.com/blogs/substack► Love To The Seventh Power: ⁠https://chakaruna.com/collections/books⁠Subscribe to the Aubrey Marcus podcast:►iTunes |⁠ ⁠⁠⁠⁠⁠⁠https://apple.co/2lMZRCn ⁠⁠⁠⁠⁠⁠⁠►Spotify |⁠⁠⁠⁠⁠⁠⁠ https://spoti.fi/2EaELZO ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠►IHeartRadio |⁠ ⁠⁠⁠⁠⁠⁠https://ihr.fm/3CiV4x3 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠►Partner with the Aubrey Marcus Podcast | https://www.aubreymarcus.com/pages/booking

Fibromyalgia and adrenal fatigue go hand in hand — and most people are never told why. In this episode, Nurse Doza breaks down five things you need to understand: why fibromyalgia is a nervous system stuck in fight-or-flight, how your adrenals burn out first, why DHEA-S is the one lab that reveals severity, and how to restore rest-and-digest mode with targeted adrenal and neurotransmitter support. Featured Product: Zen Years stuck in fight-or-flight leave your adrenal glands running on empty — and that burnout is the fatigue, poor recovery, and wired-but-tired feeling at the center of fibromyalgia. Zen is an adaptogen formula built for exactly that. It pairs bovine adrenal glandular tissue with a comprehensive blend of botanical adaptogens, B vitamins, and vitamin C to support your stress response, steadier energy, and a calmer nervous system. Take one capsule twice daily to start supporting the system from the inside.

In this episode of the Female Health Solution podcast, I'm doing something a little different. Instead of walking through the science, I'm sharing the real stories of three women I've worked with recently—each doing all the "right" things, yet feeling stuck, dismissed, and frustrated. If you've ever been told your labs are "fine" while you know something is off, these stories are for you. You're not crazy, and you're not too far gone. Case #1: The 44-Year-Old ER Doctor She was wired but exhausted, running on caffeine and adrenaline through brutal shifts, and couldn't sleep without a pill. A one-off cortisol test came back "perfect," but it never mapped her full circadian rhythm. When we ran proper testing, we found chronically elevated cortisol and blood sugar instability driving her sleep issues. With targeted support (Chinese herbs, blood sugar regulation, and adequate protein—just 4 to 5 supplements, not 20), she was sleeping deeply without a pill within three months, dreaming again, and sharper at work. Case #2: The 51-Year-Old CEO She had meals prepped, a trainer, total accountability—and still couldn't budge the tire around her belly. She assumed it was menopause, but it was really insulin resistance (a "normal" glucose of 98, with fasted insulin never tested) layered on a completely flat cortisol curve. She was also severely under-eating for her stress and output. I had her eat significantly more, which terrified her—yet she lost three pounds in the first six weeks as her body finally started functioning instead of just surviving. Case #3: The 37-Year-Old Mom of Three She told me she didn't recognize herself anymore—snapping at her kids, feeling like a "rage monster," then drowning in guilt. This wasn't a character flaw or bad mindset; it was physiology. Her inverted cortisol curve was tanking her progesterone (which fuels the calming GABA receptors), and her liver wasn't processing well—where anger and irritability literally get held. Within the first month of supporting her liver and reversing that cortisol pattern, her mood transformed. My favorite win? She started listening to her old-school Taylor Swift again and became the fun mom she'd always wanted to be. The Common Thread All three women were right that something was wrong—and all three needed the right testing in the right order to fix it. You can't out-supplement a liver processing issue or out-train insulin resistance. When we identify what's actually happening and do things in the correct sequence, everything changes. If you saw yourself in any of these stories, head to the show notes and download my Hormone Cascade Map so you can start doing the right things at the right time. And if you're sick and tired of feeling stuck and being dismissed, click the link to schedule a strategy call with my team. We'll look at what you've tried, run the in-depth functional testing you actually need, and build a customized plan to get you real results. You deserve answers—let's get them.  

本集節目由【豐傑生醫】贊助播出 你有發現記憶深刻的事情通常是壞事情嗎? 為什麼別人稱讚你五分鐘就忘了 但有人嗆你一句卻能記一輩子? 這集聊的是一件你一定有感覺 卻很少停下來想的事 我們打開新聞、滑開社群 排在最前面討論最熱烈的幾乎都是壞消息 其實不是這個世界突然變壞了 而是我們的大腦天生就是一台「壞消息雷達」 如果你最近覺得社會好亂心情總被新聞牽著走 那這集很適合你來解惑我們的大腦是如何運作的 你會更懂自己為什麼會這樣 也會聊聊要如何與壞消息和平共處 開頭的「哈拉新體驗」 聊聊五月中開通的淡江大橋 從一開始發想到卡關一直聊到完工 過程中發生了哪些有趣的故事 可以讓你下次經過淡江大橋時 會對這座橋有更多的感受與體驗 一起來了解這座創下世界紀錄的淡江大橋吧！ -------------------------------------------- ⚡哈拉充能量 × 豐傑生醫 限時優惠⚡

If you are exhausted all day, wired at night, and waking up between 2:00 and 4:00 AM with your heart pounding and your brain suddenly wide awake, this episode is for you. Because midlife sleep issues are rarely just about needing more progesterone or taking a melatonin gummy. They are usually a sign that a whole system is asking to be recalibrated. In this episode, I go deeper into the sleep side of the midlife stress puzzle and break down what may actually be happening beneath the surface. In this episode: Why so many women in midlife feel exhausted all day but wide awake at night Why progesterone can help sleep, but is not always the whole answer How oral progesterone works through allopregnanolone and the GABA system Why stress affects progesterone through disrupted ovulation, not "progesterone steal" How estradiol affects serotonin, dopamine, acetylcholine, and your circadian rhythm Why estrogen decline can destabilize sleep, mood, body temperature, and stress resilience How melatonin really works and why it is more than just a sleep supplement Why blood sugar drops can trigger cortisol and adrenaline spikes in the middle of the night What adrenaline wakeups feel like and why they are so common in midlife How to start becoming your own detective with sleep, stress, hormones, and testing Who this episode is for This episode is for women in perimenopause and menopause who are waking up between 2:00 and 4:00 AM, struggling to stay asleep, feeling anxious for no clear reason, or finding that the old sleep advice is no longer working. It is especially for women who want a deeper understanding of what is happening hormonally and neurologically, instead of being told to just take more progesterone and hope for the best.   Use coupon code SLEEP to get 20% off our Progest Sleep oil. Get 15% off DHEA 10 mg capsules here. Use coupon code DHEA15! Order your own Adrenal Stress Kit or DUTCH kit here.     Sponsors Get 30% off BATCH Gummies. Go to hellobatch.com/HORMONE and use code HORMONE at checkout. Get 15% off BiOptimzers Masszymes and all other products at bioptimizers.com/hormone with coupon code HORMONE. Try Mito Q Hormone and metabolic control www.mitoq.com/karenmartel Code: MARTEL10     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

You're not depressed. You're not in crisis. You're functioning, showing up, holding it all together. But something is still off, and you can't quite name it.This episode is for that person.Brandi and Dr. Desiree Caruso, ND sit down to break down the real biology behind low-grade mood dysregulation — the kind that doesn't show up in standard bloodwork but is absolutely happening in your body. We're talking about two specific functional mushrooms, lion's mane and reishi, and going straight into the mechanisms: the actual compounds, the actual pathways, and the actual research that explains why these mushrooms have a genuine relationship with how you feel.This is not a vibe episode. This is the science.We've been asked over and over again whether functional mushrooms can do something for mood, and if so, how. Today we answer that question properly. If you've ever walked out of a doctor's appointment feeling dismissed — told everything looks normal, maybe it's stress, maybe it's your age — this episode is what comes next.What you'll learn:Why mood is a physiological state, not just a feeling, and what that means for how you address itThe specific terpenoid compounds in lion's mane (hericenones) that can cross the blood-brain barrier and what they do once they get thereWhy BDNF is the mechanism most antidepressants are thought to work through, and how lion's mane stimulates it directlyHow 90% of your serotonin is produced in your gut, and exactly how lion's mane supports that pathwayThe three-directional approach lion's mane takes: blood-brain barrier, neuroinflammation, and gut-brain axis simultaneouslyWhat the HPA axis is, why chronic stress dysregulates it, and how reishi's ganoderic acids help restore the natural cortisol rhythmReishi's relationship with GABA, the brain's calming neurotransmitter, and why that explains the felt sense of settling downThe 2026 randomized controlled trial showing measurable reductions in anxiety, cortisol, and inflammation at 12 weeksHow disrupted sleep literally changes how your brain processes emotional information, and the two specific mechanisms reishi addresses to help with thatHow to self-diagnose which mushroom fits your experience right now, and what to track over four weeks to know whether it's workingResources Mentioned:Dr. Andrew Huberman episode on adenosine and coffee: https://www.hubermanlab.com/episode/using-caffeine-to-optimize-mental-and-physical-performanceVigna, L. et al. (2019). "Hericium erinaceus Improves Mood and Sleep Disorders in the Elderly." Journal of Medicinal Food, 22(5).Contato, A.G. & Conte-Junior, C.A. (2025). "Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential — A Narrative Review." Nutrients, 17(8), 1307.Frontiers in Nutrition (2025). "Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review." Frontiers in Nutrition, 12, 1641246.Ratto, D. et al. (2023). "Hericium erinaceus: Acute and Chronic Effects on Cognitive Function, Stress, and Mood in Young Adults." Nutrients, 15(22), 4842.Cui, X.Y. et al. (2012). "Extract of Ganoderma lucidum prolongs sleep time in rats." Journal of Ethnopharmacology / Pharmacology Biochemistry and Behavior. PMID: 22297086.Yong, V.K.J. et al. (2026). "A blend of medicinal mushrooms including Reishi reduces anxiety, cortisol and CRP in a 12-week randomized controlled trial." Brain and Behavior.Your Next Steps:Follow us on Instagram: https://www.instagram.com/eversiowellness/Shop Eversio Wellness and save 15% with code PODCAST15: https://www.eversiowellness.com/discount/PODCAST15?redirect=%2Fcollections%2Fall-productsTake our wellness quiz to find the right mushroom for you: https://www.eversiowellness.com/pages/take-our-quiz

Dr. Scott Sherr is an Internal Medicine Physician certified in Health Optimization Medicine (HOMe), a hyperbaric oxygen therapy (HBOT) expert with over a decade of clinical experience, and the COO of Troscriptions, a company that creates precision-dosed buccal troches with cutting-edge ingredients, including methylene blue and GABA modulators.

Ƙungiyar Kare Hakkin Bil'adama ta Amnesty International ta bukaci gwamnatin Najeriya da ta dauki matakai na gaggawa don kare dalibai da kuma ceto wadanda har yanzu suke hannun masu garkuwa da mutane. Ƙungiyar ta jaddada cewa gazawar hukumomi wajen kawo ƙarshen hare-hare da sace-sacen dalibai na nuna cewa rayuwar yara na cikin matsananciyar barazana. Ƙungiyar ta bukaci Shugaba Tinubu da ya dauki matakin gaggawa na kawo karshen satar yara da kai hari makarantu, tana mai cewa iyaye sun gaji da romon bakar da ake musu. Amnesty ta zargi gwamnatin da kasa kare kananan hukumomi, musamman a jihar Zamfara da sauran yankunan Arewa daga hare-haren yan bindiga. Kungiyar ta nuna damuwa kan yadda tsadar rayuwa da matsalar tsaro ke raba iyalai da muhallansu, lamarin da ke jefa yara da dama cikin yunwa da rashin ilimi. Kan wannan ne Bashir Ibrahim Idris ya tattauna da Daraktan Ƙungiyar a Najeriya Isah Sunusi. Shiga alamar sauti, domin sauraron cikakkiyar tattaunawar.

What if your cravings, mood swings, brain fog, and emotional overwhelm were signs of a nutrient deficiency rather than a lack of willpower? As we age, hormonal shifts, chronic stress, poor sleep, and nutrient depletion can significantly impact brain chemistry. Many people over 40 experience increased anxiety, brain fog, sugar cravings, and emotional volatility without realizing that amino acid deficiencies may be contributing. In this episode of The Health Fix Podcast, Laurie Hammer shares her powerful personal journey with amino acid therapy and how it transformed her mental health, cravings, emotional resilience, and overall brain function. We dive into the science behind amino acids as the building blocks of neurotransmitters and why they can be especially supportive for adults over 40 navigating stress, detoxification, and hormonal changes. You'll learn how amino acid testing works, the signs of deficiency, and practical ways to integrate amino acid support into a holistic health plan. About Laurie Hammer Being a mom and business owner isn't easy. Juggling responsibilities, sleepless nights, and constant demands can feel overwhelming and Laurie knows this struggle firsthand. Before becoming a mother, Laurie battled an eating disorder, anxiety, and depression, challenges that affected her health, relationships, and overall well-being. Discovering Amino Acid Therapy changed everything, helping her reclaim her life and igniting a passion for health and wellness. With a degree in psychology and certification in nutritional therapy, Laurie created the Calm Mom Method®, a proven approach designed to help moms reduce anxiety, restore energy, and live with greater purpose and resilience. What You'll Learn In This Episode:  ✅ Laurie's personal journey with amino acid therapy and what led her to explore this approach for mental and emotional health. ✅ How amino acids influence neurotransmitters like serotonin, dopamine, and GABA—and why that matters for mood, sleep, focus, and cravings. ✅ The different ways to test amino acid levels and assess deficiencies, including how the body's responses can provide important clues. ✅ Why cravings and emotional eating may be rooted in brain chemistry rather than willpower alone. ✅ How targeted amino acid support can help with emotional regulation, stress resilience, and mental clarity. ✅ The role of amino acids in detoxification and brain health, including support for neuroprotection and recovery from chronic stress. ✅ How to integrate amino acids with functional medicine, nutrition, lifestyle habits, and other holistic health practices for a personalized approach to healing. Resources From The Show:  Check out Laurie Hammer's Website Listen in to Laurie's Podcast - Take Back My Brain Dr. Jannine Krause's Website

Gwamnatin Jihar Filato da ke Najeriya ta bayyana matuƙar damuwar ta dangane da yadda ta ce wasu na amfani da hukuncin wata kotu dangane da baiwa wasu Hausawa takardar zama ƴan ƙasa domin haifar da tashin hankali a tsakanin al'ummar da suka kwashe shekaru da dama su na zaman lafiya da juna. Gwamnatin ta ja kunnen al'umma inda ta ce waɗanda ba su gamsu da hukuncin ba na da hurumin ɗaukaka ƙara kamar yadda dokokin ƙasa da suka tanada. Bashir Ibrahim Idris ya tuntuɓi kwamishiniyar yaɗa labaran jihar da ta gabatar da sanawar, Joyce Ramnap kuma ga yadda zantawarsu ta gudanar a kai.

The real truth about Afrophobia in South Africa - Faisal Gaba by Radio Islam

A wannan makon shirin ya mayar da hankali ne kan tasirin gurɓatacciyar iska ga lafiyar halittu da muhalli wato air pollution a turance. Iska na gurɓa ta ne ta hanyoyi da dama, kama daga hayaƙin na'urori wato injina a masana'antu, zuwa tarkacen bola ko kuma ƙone wasu abubuwa, wanda su ke kawo cikas ga yanayin muhalli tare kuma da kawo tazgaro ga lafiyar ɗan Adam.

Jaume Segalés y los responsables de Mundo Natural hablan sobre el GABA.

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us

Dr. Liz Graves didn't set out to become a doctor. She discovered chiropractic as a patient, fell in love with its foundational philosophy that the body heals from the inside out, and built a career around that principle. Today, as the founder of Back 2 Real Food, she helps people restore their metabolic health through food, cyclic nutrition strategies, and targeted amino acid therapy — without relying on willpower, calorie restriction alone, or one-size-fits-all dieting.In this episode, Dr. Tara Perry sits down with Dr. Graves for a wide-ranging conversation on why so many people are doing "everything right" and still can't lose weight, what the modern food system is doing to our metabolism, and the counterintuitive strategies that actually work.Key Takeaways:The real reason diets stop working (00:07:00) — Every time you diet without recovery, your body adapts to living on less, slowing your metabolism over time. Dr. Graves explains her cyclic approach: a structured window of fat loss followed by a deliberate high-calorie phase that trains the body to metabolize more, not less.Seed oils are the #1 offender in your diet (00:16:44) — Vegetable, canola, sunflower, and safflower oils disrupt cell walls, cause inflammation at the cellular level, and impair mitochondrial function. Removing them is the first and fastest win Dr. Graves makes with every new client.Three foods worth adding right now (00:19:41) — Healthy natural fats (animal fats, olive oil, coconut oil), quality mineral-rich sea salt, and more whole foods without a label. Small additions that compound into meaningful change.Know your farmer (00:21:49) — Pesticide load, not the food itself, is driving the explosion in leaky gut, celiac, and autoimmune conditions. Dr. Graves recommends the Weston A. Price Foundation as a starting point for finding local farmers and co-ops, and makes the case that buying direct is often cheaper than buying organic at a grocery store.Targeted amino acid therapy changed everything (00:26:56) — Most people have never worked with a practitioner who assesses neurotransmitter imbalances and uses amino acids to correct them. Dr. Graves explains how depleted GABA, serotonin, and dopamine pathways fuel emotional eating, overwhelm, and burnout — and how replenishing them through targeted therapy gives people the neurological resilience to stay on course.Cortisol, stress, and weight retention (00:32:41) — Chronic low-grade stress (email, notifications, relentless demands) keeps the body in protective mode, holding weight and suppressing metabolic function. Dr. Graves connects the modern stress environment to the ancestral body we're still living in, and explains why supporting the brain matters as much as fixing the food.Body composition over the scale (00:58:06) — Dr. Graves uses body composition testing (muscle, fat, water, bone) rather than BMI or scale weight to track real progress. She shares the story of a five-foot-one woman with 105 pounds of muscle who technically "should" weigh 100 pounds — and why that framing is misleading and discouraging.What results actually look like (00:47:24) — On Dr. Graves' six-week protocol, most people lose about 10 pounds and drop one clothing size. On the nine-week plan, 15 to 30 pounds and two clothing sizes. She describes it as achieving six to nine months of focused progress in six to nine weeks — structured and demanding while you're in it, but consistently described as the easiest thing clients ever did when they look back.Ready to take your own next step?Visit calendly.com/consulttara/consult to book your free customized consultation with Dr. Tara Perry and get your GPS map — the coordinates for where you are now and where you want to go.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Now it came to pass, when the wall was built, and I had set up the doors, and the porters and the singers and the Levites were appointed,2 That I gave my brother Hanani, and Hananiah the ruler of the palace, charge over Jerusalem: for he was a faithful man, and feared God above many.3 And I said unto them, Let not the gates of Jerusalem be opened until the sun be hot; and while they stand by, let them shut the doors, and bar them: and appoint watches of the inhabitants of Jerusalem, every one in his watch, and every one to be over against his house.4 Now the city was large and great: but the people were few therein, and the houses were not builded.5 And my God put into mine heart to gather together the nobles, and the rulers, and the people, that they might be reckoned by genealogy. And I found a register of the genealogy of them which came up at the first, and found written therein,6 These are the children of the province, that went up out of the captivity, of those that had been carried away, whom Nebuchadnezzar the king of Babylon had carried away, and came again to Jerusalem and to Judah, every one unto his city;7 Who came with Zerubbabel, Jeshua, Nehemiah, Azariah, Raamiah, Nahamani, Mordecai, Bilshan, Mispereth, Bigvai, Nehum, Baanah. The number, I say, of the men of the people of Israel was this;8 The children of Parosh, two thousand an hundred seventy and two.9 The children of Shephatiah, three hundred seventy and two.10 The children of Arah, six hundred fifty and two.11 The children of Pahathmoab, of the children of Jeshua and Joab, two thousand and eight hundred and eighteen.12 The children of Elam, a thousand two hundred fifty and four.13 The children of Zattu, eight hundred forty and five.14 The children of Zaccai, seven hundred and threescore.15 The children of Binnui, six hundred forty and eight.16 The children of Bebai, six hundred twenty and eight.17 The children of Azgad, two thousand three hundred twenty and two.18 The children of Adonikam, six hundred threescore and seven.19 The children of Bigvai, two thousand threescore and seven.20 The children of Adin, six hundred fifty and five.21 The children of Ater of Hezekiah, ninety and eight.22 The children of Hashum, three hundred twenty and eight.23 The children of Bezai, three hundred twenty and four.24 The children of Hariph, an hundred and twelve.25 The children of Gibeon, ninety and five.26 The men of Bethlehem and Netophah, an hundred fourscore and eight.27 The men of Anathoth, an hundred twenty and eight.28 The men of Bethazmaveth, forty and two.29 The men of Kirjathjearim, Chephirah, and Beeroth, seven hundred forty and three.30 The men of Ramah and Gaba, six hundred twenty and one.31 The men of Michmas, an hundred and twenty and two.32 The men of Bethel and Ai, an hundred twenty and three.33 The men of the other Nebo, fifty and two.34 The children of the other Elam, a thousand two hundred fifty and four.35 The children of Harim, three hundred and twenty.36 The children of Jericho, three hundred forty and five.37 The children of Lod, Hadid, and Ono, seven hundred twenty and one.38 The children of Senaah, three thousand nine hundred and thirty.39 The priests: the children of Jedaiah, of the house of Jeshua, nine hundred seventy and three.40 The children of Immer, a thousand fifty and two.41 The children of Pashur, a thousand two hundred forty and seven.42 The children of Harim, a thousand and seventeen.43 The Levites: the children of Jeshua, of Kadmiel, and of the children of Hodevah, seventy and four.44 The singers: the children of Asaph, an hundred forty and eight.45 The porters: the children of Shallum, the children of Ater, the children of Talmon, the children of Akkub, the children of Hatita, the children of Shobai, an hundred thirty and eight.46 The Nethinims: the children of Ziha, the children of Hashupha, the children of Tabbaoth,47 The children of Keros, the children of Sia, the children of Padon,48 The children of Lebana, the children of Hagaba, the children of Shalmai,49 The children of Hanan, the children of Giddel, the children of Gahar,50 The children of Reaiah, the children of Rezin, the children of Nekoda,51 The children of Gazzam, the children of Uzza, the children of Phaseah,52 The children of Besai, the children of Meunim, the children of Nephishesim,53 The children of Bakbuk, the children of Hakupha, the children of Harhur,54 The children of Bazlith, the children of Mehida, the children of Harsha,55 The children of Barkos, the children of Sisera, the children of Tamah,56 The children of Neziah, the children of Hatipha.57 The children of Solomon's servants: the children of Sotai, the children of Sophereth, the children of Perida,58 The children of Jaala, the children of Darkon, the children of Giddel,59 The children of Shephatiah, the children of Hattil, the children of Pochereth of Zebaim, the children of Amon.60 All the Nethinims, and the children of Solomon's servants, were three hundred ninety and two.61 And these were they which went up also from Telmelah, Telharesha, Cherub, Addon, and Immer: but they could not shew their father's house, nor their seed, whether they were of Israel.62 The children of Delaiah, the children of Tobiah, the children of Nekoda, six hundred forty and two.63 And of the priests: the children of Habaiah, the children of Koz, the children of Barzillai, which took one of the daughters of Barzillai the Gileadite to wife, and was called after their name.64 These sought their register among those that were reckoned by genealogy, but it was not found: therefore were they, as polluted, put from the priesthood.65 And the Tirshatha said unto them, that they should not eat of the most holy things, till there stood up a priest with Urim and Thummim.66 The whole congregation together was forty and two thousand three hundred and threescore,67 Beside their manservants and their maidservants, of whom there were seven thousand three hundred thirty and seven: and they had two hundred forty and five singing men and singing women.68 Their horses, seven hundred thirty and six: their mules, two hundred forty and five:69 Their camels, four hundred thirty and five: six thousand seven hundred and twenty asses.70 And some of the chief of the fathers gave unto the work. The Tirshatha gave to the treasure a thousand drams of gold, fifty basons, five hundred and thirty priests' garments.71 And some of the chief of the fathers gave to the treasure of the work twenty thousand drams of gold, and two thousand and two hundred pound of silver.72 And that which the rest of the people gave was twenty thousand drams of gold, and two thousand pound of silver, and threescore and seven priests' garments.73 So the priests, and the Levites, and the porters, and the singers, and some of the people, and the Nethinims, and all Israel, dwelt in their cities; and when the seventh month came, the children of Israel were in their cities.

In this episode, Leigh Ann welcomes Dr. Scott Sherr, co-founder of Troscriptions, for a conversation on GABA, anxiety, stress, sleep, and fast-acting nervous system support. Dr. Sherr shares how his background in internal medicine, hyperbaric oxygen therapy, and health optimization medicine led him to help create products designed to support people while they are on a longer healing journey. He explains why many people may be struggling with GABA deficiency, how chronic stress can deplete the body's calming pathways, and why anxiety, insomnia, racing thoughts, and low energy are often interconnected. Leigh Ann and Dr. Sherr discuss the unique buccal troche delivery method, how it differs from capsules and sublingual supplements, and why it can allow for faster absorption and more flexible dosing. The conversation also explores TroCalm, Trozy, alcohol's impact on the GABA-glutamate balance, sleep architecture, and why calming the nervous system does not have to mean feeling sedated.Product Discount Codes + LinksHoolest: Website (Discount Code: THEACCRESCENT10)Froya Hair Care: Website (Link gives 10% off)Herbal Face Food: Website (Discount Code: LAL30)Episode LinksTroscriptions - Website (Discount Code: LEIGHANN)Guest InfoDr. Scott Sherr - WebsiteRelated EpisodesPodcast Ep. 203: Anna Finck - Reconnecting to Our Bodies, Reclaiming Our Health, and Remembering Our PowerPodcast Ep. 150: Michael Byrne - The Bia Smart Sleep MaskWork w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Healing Alchemy MembershipConnect w/Me & Learn MoreWebsiteInstagramTiktokYoutube

Drs. Ken Johnson, Jaideep J. Pandit and Peter Goldstein discuss the article "Are "GABAergic" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro" published in the June 2026 issue of Anesthesia & Analgesia.

If you've been doing everything right and still feel exhausted, anxious, and like your body just won't cooperate — this episode is for you. I sat down with Dr. Scott Sherr, a board-certified internal medicine physician and COO of Troscriptions, to talk about the sympathetic spiral: a chronic fight-or-flight loop most people don't even know they're in. And here's what surprised me most — you don't have to feel stressed to be stuck in it. We get into why your cellular energy and your anxiety are locked in a loop, what mitochondrial dysfunction actually means for your daily life, and how a specific sequence of support can help you finally start feeling better. We also go deep on methylene blue — the history, how it works, the right dosing range, and the sourcing and safety details that most people skip (including who should absolutely not use it). Plus: why GABA deficiency is so common, how to calm your nervous system without sedating yourself, and why sleep is a full-day practice — not just a bedtime routine. For the complete show notes, links and transcripts, visit inspiredliving.show/247

In this episode of the Essential Wellness Podcast, Aisha Harley welcomed certified aromatherapist and holistic health coach PJ Hanks for an in-depth yet approachable discussion on the science behind essential oils. PJ explained how essential oils work at a cellular level through specific targets, pathways, and biological mechanisms, helping listeners better understand why these plant compounds can have such profound effects on health and wellness.   The conversation explored the importance of oil quality, absorption methods, synergy between compounds, and the unique benefits of oils like Frankincense, Lavender, Copaiba, and Rose. PJ also shared practical application tips and dosing recommendations to help listeners maximize the benefits of their oils.  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter dives into the pharmacology of sleep, exploring where sleep medications fit within the broader framework of achieving healthy, restorative sleep. He explains why sleep is a biological imperative, why behavioral and environmental interventions must remain the foundation of good sleep, and how medications can serve as useful tools when carefully matched to a person's specific sleep problem. Peter examines the major classes of prescription sleep medications, including how they work, their effects on sleep architecture, their duration of action, side effects, and risks of tolerance and dependence. He also discusses the dangers of using sleep drugs without a clear understanding of the underlying problem being treated, the role of medications as short-term bridges during periods of acute stress, pain, or anxiety, and the promise that newer drugs like DORAs may hold for Alzheimer's prevention in high-risk individuals. Finally, Peter reviews the evidence for select off-label medications and supplements commonly used for sleep. We discuss: The biological foundations of sleep, the major drivers of sleep dysfunction, and the role sleep medications can play when appropriately matched to specific sleep problems [1:00]; Sleep hygiene, circadian alignment, and the medical causes of insomnia: building the foundation for effective sleep treatment [7:15]; Understanding insomnia: hyperarousal, CBT-I, paradoxical insomnia, and why different sleep problems require different treatments [12:45]; The difference between sedation and physiologic sleep: sleep architecture, restorative sleep stages, and matching medications to specific sleep problems [17:00]; Benzodiazepines for insomnia: mechanisms, effects on sleep architecture, and the risks of long-term use [18:45]; Z-drugs for insomnia: how Ambien, Sonata, and Lunesta work, and the ongoing risks of sleep medications targeting GABA systems [23:00]; Dual orexin receptor antagonists (DORAs) and the future of sleep medicine: orexin signaling, sleep architecture, and the emerging connection between sleep and Alzheimer's disease [27:15]; Melatonin for circadian timing: how timing signals differ from sedatives in the treatment of sleep disorders [36:30]; Trazodone for insomnia: preserving deep sleep while minimizing the risks of traditional sedative-hypnotics [42:00]; First-generation antihistamines for sleep: short-term sedation, anticholinergic risks, and concerns about long-term cognitive health [44:00]; Sleep supplements and the evidence behind them: glycine, magnesium, ashwagandha, phosphatidylserine, and more [45:45]; Takeaways: supplement quality, individualized sleep treatment, and the importance of matching interventions to the biology of insomnia [52:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Serotonin does far more than regulate mood — 90% of it is made in your gut, not your brain. In this episode, Nurse Doza breaks down exactly what serotonin does, why so many people are unknowingly depleted, and how to naturally restore levels through gut health, B vitamins, sunlight, and targeted supplementation.   FEATURED PRODUCT Bliss by MSW Nutrition Serotonin production depends on methylation — and if your methylation pathways are sluggish, you can be doing everything right and still come up short. Bliss is a lemon-flavored sublingual powder featuring TMG (trimethylglycine), a powerful methyl donor that directly supports the methylation reactions your body needs to synthesize serotonin and dopamine. As discussed in this episode, the MTHFR gene, B vitamins, and SAMe are all essential cofactors in serotonin production — and Bliss is formulated to address exactly that gap. Just place it on your tongue and let it absorb in seconds. One serving a day is all it takes.

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We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling. In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions. This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition. If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on. In this episode, we cover: Why brain fog is such a common midlife complaint What mitochondria actually are and why they matter for brain energy How estrogen loss may contribute to mitochondrial dysfunction How methylene blue may support mitochondria, energy production, and mental clarity The difference between low-dose and high-dose methylene blue use The truth about methylene blue and nitric oxide Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain How stress and sympathetic overload affect mood, sleep, and focus Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support Why HRT may help, but may not be the whole story for every woman Who this episode is for This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms.   Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He's the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients. Troscriptions: Use coupon code HORMONE for 10% off your order.     Sponsors Get 15% off Masszymes at bioptimizers.com/hormone  Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back!  Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Welcome to MENO — your go-to for perimenopause, menopause, and everything in between. In this episode, we sit down with Dr. Allie Sharma, a Cornell-trained psychiatrist and Co-founder of Being Health. Dr. Sharma's backstory includes working with trauma survivors in post-conflict countries like Afghanistan and marginalized populations in the South Bronx. Despite her elite training, she reveals she learned zero about menopause in medical school—a gap she now solves through an integrated mental health model that bridges the gap between hormones and the brain. IN THIS EPISODE, WE COVER: -The 40% Surge: Why the risk of depression can be 40% higher in perimenopause than premenopause. -Neurotransmitter 101: How estrogen directly impacts serotonin, dopamine, and norepinephrine metabolism. -The GABA Connection: Why progesterone acts as a natural "calming" hormone on the brain's GABA pathway. -The Truth About the Pill: Why standard birth control may not be the right solution for perimenopausal mood shifts. -Biohacking with Ketamine: How infusion therapy facilitates a "neuroplastic window" to treat resistant depression. -The SSRI Libido Myth: Navigating sexual side effects and finding alternative treatments like SNRIs or Wellbutrin. -Ancient Medicine, Modern Results: Why the WHO endorses acupuncture for treating depression. -CBT for Menopause: Using Cognitive Behavioral Therapy to manage the psychological distress of hot flashes. RESOURCES beinghealth.co Dr. Allie Sharma on IG @alliesharmamd @mentalhealthcoalition @beinghealthcare ABOUT MENO MENO is the definitive platform for menopause and perimenopause care — connecting women to trusted experts, solutions, and support https://joinmeno.com/ https://www.instagram.com/join.meno https://www.tiktok.com/@join.meno Follow our Founder/CEO on Instagram @jacquelinebuckingham Disclaimer: MENO is for general information and entertainment purposes only and does not constitute the practice of medicine in any way. MENO does not constitute professional health care services or medical advice. No doctor/patient relationship is formed as a result of this podcast. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of MENO is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard getting medical advice for any such medical condition they may have and should seek the assistance of their healthcare professionals for any conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

Darien, CT A new way to help alleviate Neuropathic Pain is using Transcutaneous Pulsed Radio frequency therapy. This treatment helps quiet pain signals coming from the brain in several ways. Lets use tPRF to describe the therapy.Chronic pain bombards the brain, like a phone left off the hook-the pain signals are trying to get the brain's attention. The electromagnetic field created by tPRF quiets the oversensitized nerves. When this happens, it is called allodynia. This presents as extreme pain being felt where it should not. The damaged nerves can deplete neurotransmitters that facilitate normal nerve firing. GABA acts like a brake on the nervous system to prevent overfiring of damaged nerves.Norepinephrine binds to receptors to block the release of pain chemicals from peripheral nerves.Serotonin is another inhibiting neurotransmitter that inhibits the transmission of pain signals. However, In chronic states, its role can become complex, sometimes facilitating pain if the system is "exhausted".How your brain stops pain. The body has a built-in "volume knob" for pain called the **Descending Inhibitory Pain Pathway**. When the brain decides to suppress pain, it sends efferent signals from the **Periaqueductal Gray (PAG)** in the midbrain down to the **Rostral Ventromedial Medulla (RVM)** and finally back into the spinal cord.This pathway works like a gatekeeper. If the "gate" in the spinal cord is closed by these descending signals, the pain message from your nerves never reaches your conscious brain.Transcutaneous Pulsed Radio frequency can help people with chronic debilitating nerve pain by changing the brain's ability to suppress pain signals. This can dramatically improve the life of a person suffering from neuropathy. If you have questions please reach out to me Dr.Brian McKay at 203-656-3636Have a Question? Just AskThis podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message.  I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4Core Health Darien-Dr.Brian Mc Kay 551 Post RoadDarien CT 06820203-656-363641.0833695 -73.46652073GMP+87 Darien, Connecticuthttps://youtu.be/WpA__dDF0O041.0834196 -73.46423349999999https://darienchiropractor.comhttps://darienchiropractor.com/darien/darien-ct-understanding-pain/Find us on Social Mediahttps://chiropractor-darien-dr-brian-mckay.business.site  https://www.youtube.com/channel/UCNHc0Hn85Iiet56oGUpX8rwhttps://docs.google.com/spreadsheets/d/1nJ9wlvg2Tne8257paDkkIBEyIz-oZZYy/edit#gid=517721981https://goo.gl/maps/js6hGWvcwHKBGCZ88https://www.youtube.com/my_videos?o=Uhttps://www.linkedin.com/in/darienchiropractorhttps://www.facebook.com/ChiropractorBrianMckayhttps://sites.google.com/view/corehealthdarien/https://sites.google.com/view/corehealthdarien/home

Now these are the children of the province that went up out of the captivity, of those which had been carried away, whom Nebuchadnezzar the king of Babylon had carried away unto Babylon, and came again unto Jerusalem and Judah, every one unto his city;2 Which came with Zerubbabel: Jeshua, Nehemiah, Seraiah, Reelaiah, Mordecai, Bilshan, Mizpar, Bigvai, Rehum, Baanah. The number of the men of the people of Israel:3 The children of Parosh, two thousand an hundred seventy and two.4 The children of Shephatiah, three hundred seventy and two.5 The children of Arah, seven hundred seventy and five.6 The children of Pahathmoab, of the children of Jeshua and Joab, two thousand eight hundred and twelve.7 The children of Elam, a thousand two hundred fifty and four.8 The children of Zattu, nine hundred forty and five.9 The children of Zaccai, seven hundred and threescore.10 The children of Bani, six hundred forty and two.11 The children of Bebai, six hundred twenty and three.12 The children of Azgad, a thousand two hundred twenty and two.13 The children of Adonikam, six hundred sixty and six.14 The children of Bigvai, two thousand fifty and six.15 The children of Adin, four hundred fifty and four.16 The children of Ater of Hezekiah, ninety and eight.17 The children of Bezai, three hundred twenty and three.18 The children of Jorah, an hundred and twelve.19 The children of Hashum, two hundred twenty and three.20 The children of Gibbar, ninety and five.21 The children of Bethlehem, an hundred twenty and three.22 The men of Netophah, fifty and six.23 The men of Anathoth, an hundred twenty and eight.24 The children of Azmaveth, forty and two.25 The children of Kirjatharim, Chephirah, and Beeroth, seven hundred and forty and three.26 The children of Ramah and Gaba, six hundred twenty and one.27 The men of Michmas, an hundred twenty and two.28 The men of Bethel and Ai, two hundred twenty and three.29 The children of Nebo, fifty and two.30 The children of Magbish, an hundred fifty and six.31 The children of the other Elam, a thousand two hundred fifty and four.32 The children of Harim, three hundred and twenty.33 The children of Lod, Hadid, and Ono, seven hundred twenty and five.34 The children of Jericho, three hundred forty and five.35 The children of Senaah, three thousand and six hundred and thirty.36 The priests: the children of Jedaiah, of the house of Jeshua, nine hundred seventy and three.37 The children of Immer, a thousand fifty and two.38 The children of Pashur, a thousand two hundred forty and seven.39 The children of Harim, a thousand and seventeen.40 The Levites: the children of Jeshua and Kadmiel, of the children of Hodaviah, seventy and four.41 The singers: the children of Asaph, an hundred twenty and eight.42 The children of the porters: the children of Shallum, the children of Ater, the children of Talmon, the children of Akkub, the children of Hatita, the children of Shobai, in all an hundred thirty and nine.43 The Nethinims: the children of Ziha, the children of Hasupha, the children of Tabbaoth,44 The children of Keros, the children of Siaha, the children of Padon,45 The children of Lebanah, the children of Hagabah, the children of Akkub,46 The children of Hagab, the children of Shalmai, the children of Hanan,47 The children of Giddel, the children of Gahar, the children of Reaiah,48 The children of Rezin, the children of Nekoda, the children of Gazzam,49 The children of Uzza, the children of Paseah, the children of Besai,50 The children of Asnah, the children of Mehunim, the children of Nephusim,51 The children of Bakbuk, the children of Hakupha, the children of Harhur,52 The children of Bazluth, the children of Mehida, the children of Harsha,53 The children of Barkos, the children of Sisera, the children of Thamah,54 The children of Neziah, the children of Hatipha.55 The children of Solomon's servants: the children of Sotai, the children of Sophereth, the children of Peruda,56 The children of Jaalah, the children of Darkon, the children of Giddel,57 The children of Shephatiah, the children of Hattil, the children of Pochereth of Zebaim, the children of Ami.58 All the Nethinims, and the children of Solomon's servants, were three hundred ninety and two.59 And these were they which went up from Telmelah, Telharsa, Cherub, Addan, and Immer: but they could not shew their father's house, and their seed, whether they were of Israel:60 The children of Delaiah, the children of Tobiah, the children of Nekoda, six hundred fifty and two.61 And of the children of the priests: the children of Habaiah, the children of Koz, the children of Barzillai; which took a wife of the daughters of Barzillai the Gileadite, and was called after their name:62 These sought their register among those that were reckoned by genealogy, but they were not found: therefore were they, as polluted, put from the priesthood.63 And the Tirshatha said unto them, that they should not eat of the most holy things, till there stood up a priest with Urim and with Thummim.64 The whole congregation together was forty and two thousand three hundred and threescore,65 Beside their servants and their maids, of whom there were seven thousand three hundred thirty and seven: and there were among them two hundred singing men and singing women.66 Their horses were seven hundred thirty and six; their mules, two hundred forty and five;67 Their camels, four hundred thirty and five; their asses, six thousand seven hundred and twenty.68 And some of the chief of the fathers, when they came to the house of the Lord which is at Jerusalem, offered freely for the house of God to set it up in his place:69 They gave after their ability unto the treasure of the work threescore and one thousand drams of gold, and five thousand pound of silver, and one hundred priests' garments.70 So the priests, and the Levites, and some of the people, and the singers, and the porters, and the Nethinims, dwelt in their cities, and all Israel in their cities.

Brain fog in perimenopause isn't inevitable decline.Brain fog in perimenopause isn't inevitable decline. It's a systems puzzle, and once you understand what's actually driving it, you can do something about it. In this episode I'm joined by Dr. Sarah McKay, neuroscientist and author of The Women's Brain Book, and we break down the real neuroscience behind why your brain feels different in midlife, what the research actually says about HRT and brain health, and the evidence-based strategies to protect and optimise your cognitive performance. WHAT YOU'LL LEARN • What actually causes perimenopause brain fog (it's not just your hormones) • How night sweats disrupt sleep architecture even when you don't fully wake up • Why anxiety and waking at 3am are early signs of the perimenopause transition • What the research really says about estrogen, progesterone, and testosterone on brain health • Why the progesterone and GABA sleep claim is not what it seems • How your career and daily habits are already shaping your long-term dementia risk • Why your mindset about aging may be affecting your cognitive performance • The daily framework for protecting your brain: sleep, nutrition, strength training, and stress TIMESTAMPS: VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Dr Paul Saladino reacts to new comments from Jordan Peterson's wife describing him as living in “another realm of pain” from benzodiazepine injury years after first being prescribed the drug for severe anxiety and autoimmune‑driven insomnia. He explains how benzos like Xanax, clonazepam and Valium act on GABA receptors in ways similar to alcohol, why withdrawal can be medically dangerous, and how long term use may leave lasting changes in the brain that are extremely hard to reverse.

What if the most powerful tool for mental health recovery isn't a medication — it's your metabolism?  Dr. Erin Louise Bellamy joins Dr. Vera Tarman for a deep dive into ketogenic metabolic therapy: what it is, how it works, and why it may be one of the most underutilized interventions in both psychiatric care and food addiction recovery.  Dr. Bellamy is a chartered psychologist, CEO of IKRT (International Ketogenic Research & Therapy), and a research fellow at the University of East London. She has been researching and applying ketogenic metabolic therapy in clinical settings since 2014, with a background that bridges eating disorders, psychiatric research, and metabolic health.  In this episode, Vera and Erin discuss:  How Erin went from eating disorder and alexithymia research to ketogenic metabolic psychiatry — and why the field's "biopsychosocial" model was missing the bio  The difference between metabolic psychiatry, ketogenic therapy, and therapeutic carbohydrate restriction — and why the terminology matters  What carbohydrate range actually produces therapeutic ketosis (and why "dirty keto" doesn't cut it)  The shared mechanistic pathways across psychiatric diagnoses — including mitochondrial dysfunction, insulin resistance, and neuroinflammation  Why antipsychotic medications create metabolic dysfunction, and how ketogenic therapy can help offset those side effects  The GABA/glutamate shift that makes ketones naturally anxiolytic — and why this may work differently than the serotonin model of depression  The "buffer effect": what it feels like to be in ketosis when you're a food addict — and why some people describe it as a pane of glass between themselves and a trigger food  How ketogenic therapy compares to GLP-1 medications (Ozempic/Wegovy) for reducing food noise — and Erin's concerns about the long-term research  MCT oil vs. exogenous ketones: when each is useful, and when exogenous ketones are counterproductive  Applying ketogenic therapy to people with ADHD, bipolar disorder, and co-occurring food addiction  How to support vegan or plant-based clients who want to pursue ketogenic therapy  Why the first week matters most — and how to help clients through withdrawal without triggering a binge  The 19-person IKRT group program published in Frontiers — and what's coming next in the research  Connect with Dr. Erin Bellamy:  

In this episode we talk about the science behind alcohol and what it's actually doing to your brain, nervous system, hormones, gut health, mood, anxiety, and overall well-being.We dive into:*GABA, dopamine, serotonin, and why alcohol feels relaxing at first*why anxiety and emotional lows increase after drinking*the gut-brain connection and inflammation*how alcohol affects women differently as we age*hormones, cortisol, sleep, muscle recovery, and mood*why “moderation” can feel so exhausting*what really happens when you remove alcohol*the emotional and spiritual side of becoming alcohol-freeThis episode is not about shame or labeling yourself. It's about understanding what's happening in your body so you can make empowered decisions and reconnect with yourself on a deeper level.If you've been questioning your relationship with alcohol, feeling disconnected from yourself, or craving a healthier and more aligned life, this episode is for you.Connect and work with me:Instagram: HereWork with me: Here

Does GABA Actually Help With Sleep? What the Research Says for Brain Injury Recovery Someone in our community recently asked me about GABA for sleep. They’d seen it recommended online, understood that sleep was critical for their recovery, and wanted to know whether the supplement was worth exploring or just noise. It’s a genuinely good question. And it deserves a proper answer. In this post, I’m going to walk you through what GABA is, what the clinical research actually shows about its effect on sleep, why the blood-brain barrier debate matters (and why it might not derail the whole argument), and what the evidence says about the relationship between sleep and brain recovery. By the end, you’ll have enough to have an informed conversation with your medical team. I’m not a doctor. I’m a three-time haemorrhagic stroke survivor who has spent years researching the science of brain recovery and interviewing hundreds of clinicians and survivors on the Recovery After Stroke podcast. What I offer is a careful read of the evidence, not a clinical prescription. What Is GABA and Why Does It Matter for Sleep? GABA (gamma-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter. If your nervous system were a car, GABA is the brake pedal. It reduces neuronal excitability, quiets cortical arousal, suppresses the brain’s primary arousal centre (the locus coeruleus), and modulates the HPA axis, the stress-response system that drives cortisol. Most sedative medications work by amplifying GABA activity. Benzodiazepines, for instance, bind to GABA-A receptors to increase chloride channel opening, producing their calming effect. GABA isn’t doing something unusual here – it’s doing something fundamental. The question with supplemental oral GABA is more specific: Does taking GABA as a capsule or powder actually produce meaningful neurological effects? What Does the Research Show? Finding 1 — Oral GABA Reduces Sleep Latency (and EEG Can Measure It) A 2015 clinical trial published in the Journal of Nutritional Science and Vitaminology by Yamatsu and colleagues used EEG measurement, actual brainwave monitoring, rather than self-reported sleep questionnaires. One hundred milligrams of oral GABA shortened sleep latency (time to fall asleep) by 5.3 minutes compared to placebo. That might sound modest. But for someone lying awake for 30–40 minutes each night, it’s a meaningful shift. Crucially, this was objective neurophysiological data, not a survey response. (PMID: 26052150) Finding 2 — A 90-Day RCT Showed Improved Sleep Efficiency and Mood A 2024 randomised double-blind placebo-controlled trial published in the Journal of Dietary Supplements (Guimarães et al.) gave 200 mg of GABA daily for 90 days to sedentary overweight women also undergoing an exercise program. The GABA group showed significantly improved Pittsburgh Sleep Quality Index (PSQI) scores, significantly reduced depression scores, and improved heart rate variability, a marker of parasympathetic nervous system activity. The HRV finding is particularly interesting. It suggests GABA may be doing something broader than simply reducing sleep latency – it appears to support the overall physiological state that makes rest restorative. (PMID: 38321713) Finding 3 — But a High-Dose RCT Found No Effect Here’s where intellectual honesty matters. A 2023 Dutch RCT (de Bie et al.) published in the American Journal of Clinical Nutrition gave participants 500 mg of GABA three times daily, 1,500 mg/day total, and found no significant effect on self-reported sleep quality. Fasting plasma GABA wasn’t significantly elevated either, raising real bioavailability questions at that dose. This isn’t a reason to dismiss GABA entirely. It is a reason to pay attention to the dose. The evidence base supports 100–300 mg, not 1,500 mg. Higher is not better, and the non-linear dose response is clinically important. (PMID: 37495019) The Blood-Brain Barrier Debate — and Why the Gut May Be the Point The most common objection to oral GABA supplementation is this: GABA is a zwitterion at physiological pH, meaning it has low lipophilicity and poor predicted ability to cross the blood-brain barrier via passive diffusion. So if it can’t get into the brain directly, how does it produce neurological effects? The emerging explanation involves the gut-brain axis. The enteric nervous system, your gut’s own neural network, has GABA receptors. When oral GABA activates these enteric receptors, it can signal the brain via vagal afferents without needing to cross the BBB at all. Think of it as a side door rather than the front entrance. Supporting this: a 2024 RCT (Li et al.) found that a probiotic strain engineered to increase gut GABA production significantly improved objective sleep duration as measured by wearable devices, alongside reduced cortisol and suppressed HPA axis activity. The mechanism wasn’t direct CNS access – it was gut-brain signalling. (PMID: 39385735) The BBB debate doesn’t negate the clinical effect. It changes how we understand the mechanism. Why Sleep Is Not Optional in Brain Recovery This is the part that I think gets underweighted in recovery conversations — and the research is unambiguous. A 2026 large retrospective cohort study (Muhtar et al., Sleep Medicine) matched over 35,000 stroke patients and found that post-stroke insomnia was associated with a 29% higher risk of post-stroke cognitive impairment and a 30% higher risk of all-cause dementia. The association with Alzheimer’s disease was also significant. (PMID: 41924789) A 2024 observational study from Monash University and Alfred Health (Smith et al.) found that in stroke rehabilitation patients, poor sleep quality was significantly associated with higher fatigue severity and lower salivary BDNF gene expression. BDNF (brain-derived neurotrophic factor) is one of the primary molecular drivers of neuroplasticity. Less BDNF means a less receptive environment for the neurological rewiring that rehab is trying to build. (PMID: 38802847) And then there’s the glymphatic system: the brain’s waste-clearance mechanism that is most active during deep sleep. Poor sleep means reduced clearance of metabolic byproducts, including proteins associated with neurodegeneration. This is not a theoretical risk. It is an active, ongoing process. Sleep is not passive recovery. It is one of the primary mechanisms of recovery. What to Do With This Information Here are three practical steps if you’re exploring GABA for sleep: 1. Measure your sleep baseline first. Use the Pittsburgh Sleep Quality Index (freely available online) before you make any changes. Understanding whether you’re struggling with latency, duration, or quality will determine what you actually need to address. 2. If you trial GABA, choose the right form and dose. Look for PharmaGABA — naturally fermented GABA, derived from Lactobacillus hilgardii, which has the strongest clinical evidence base. A dose of 100–300 mg taken 30–60 minutes before bed is consistent with the positive studies. Avoid very high doses; the null result at 1,500 mg/day is important context. Important drug interaction note: If you are taking benzodiazepines, anticonvulsants (gabapentin, pregabalin, valproate), or any other GABAergic medication, discuss GABA supplementation with your prescriber before adding it. The additive sedative effect is a real risk. The same applies if you drink alcohol regularly. 3. Don’t skip the foundation. Sleep hygiene interventions, consistent sleep and wake times, a dark and cool room, and no screens in the 60 minutes before bed, are consistently among the highest-leverage sleep interventions in the literature. GABA may provide a genuine incremental benefit. But it cannot compensate for a fundamentally disrupted sleep environment. The Bottom Line The evidence for GABA and sleep is more substantive than I expected when I started researching it. The EEG data is real. The 90-day RCT showed meaningful clinical outcomes. The gut-brain axis mechanism is biologically plausible and now has direct RCT support. And the consequences of poor sleep in neurological recovery are not trivial – they are quantifiable, significant, and, to a degree, addressable. GABA is not a guaranteed fix. Individual responses vary. The research is not yet definitive at the level of large multi-centre trials in neurological populations. But as one tool in a comprehensive approach to sleep quality alongside good sleep hygiene, appropriate medical support, and consistent rehabilitation, the case for cautious exploration is reasonable. The next step is a conversation with your neurologist, GP, or rehab physician. Take the research with you if it’s useful. Research References All studies cited in this post are retrievable via PubMed: Yamatsu et al. — GABA sleep latency EEG clinical trial (2015) — PMID: 26052150 Guimarães et al. — GABA 200mg RCT, sleep efficiency + mood (2024) — PMID: 38321713 de Bie et al. — GABA high-dose RCT, null sleep result (2023) — PMID: 37495019 Li et al. — Gut-brain GABA axis and sleep RCT (2024) — PMID: 39385735 Muhtar et al. — Post-stroke insomnia and cognitive decline cohort (2026) — PMID: 41924789 Smith et al. — Sleep, BDNF, and fatigue in stroke rehabilitation (2024) — PMID: 38802847 This post is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making changes to your supplementation or treatment plan. If you or someone you care about is recovering from a stroke, brain injury, or any neurological condition, the Recovery After Stroke podcast and this blog exist for you. Subscribe on YouTube @BillGasiamis, or visit Recovery After Stroke to find episodes, resources, and community. The post GABA, Sleep, and Brain Health – Neurological Recovery appeared first on Recovery After Stroke.

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you've been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You're not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn't Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

Cortisol after cancer is the conversation nobody on my care team had with me. I was diagnosed with breast cancer in 2021 — invasive ductal carcinoma, stage one, grade two. I went through lumpectomy, radiation, ovarian suppression, and two years on an aromatase inhibitor before I had to come off because my bones were already in osteoporosis. Throughout all of it, my nervous system was screaming. My cortisol was running hot all day long, confirmed by a Dutch test. And not one doctor told me what stress was doing to my body or how to mitigate it. In this solo episode of Not Today Cancer, I'm walking you through the seven activities that lowered my cortisol...broken into the things that don't cost a dime (meditation, breathwork, walking outside, unplugging) and the things that do (acupuncture, energy healing, therapy). I'm also sharing the actual research behind each one, so you know this isn't woo...it's documented science.  What you'll learn: • Why cortisol is wrecked after a cancer diagnosis (and why mine was high long before) • The symptoms of high cortisol most breast cancer survivors miss • How mindfulness meditation protected the cortisol rhythm of breast cancer survivors in a randomized controlled trial • Why a single session of slow breathing drops cortisol immediately • The "nature pill" research showing 20–30 minutes outside lowers cortisol 21% per hour • Why the NCCN officially recommends acupuncture for cancer survivors If you're a breast cancer survivor, caregiver, or anyone whose body has been running on fumes...this episode is for you. We don't get the option of not mitigating stress. Pick one thing on this list and start tomorrow. Disclaimer: This episode reflects my personal experience and a summary of public research. It is not medical advice. Always consult your care team.

Anxiety has a way of making ordinary moments feel life-or-death. A simple interaction can feel significant, a passing thought can spiral into catastrophe, and your body can react as if something is deeply wrong - even when rationally you know you’re probably okay. In this episode, we get into the neuroscience behind anxiety - why your brain becomes obsessed with certain thoughts, why false alarms feel so convincing, and what actually helps when you want to feel less trapped inside your own mind. We explore: • Why anxiety feels so intense and urgent• Our physical and emotional reactions to anxiety• The role of GABA and glutamate in anxiety• Why trying to ‘stop thinking about it’ doesn’t work• How avoidance perpetuates the anxious cycle• Practical ways for living with an anxious brain Happy listening! Watch on Netflix: HERE Follow Jemma on Instagram: @jemmasbeg Follow the podcast on Instagram: @thatpsychologypodcast Subscribe on Substack: @thepsychologyofyour20s For business: psychologyofyour20s@gmail.com Our favourite sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC9559819/ https://www.nature.com/articles/nrn2555 https://www.nature.com/articles/s41386-022-01332-2 https://www.sciencedirect.com/science/article/abs/pii/S027273580000057X The Psychology of your 20s is not a substitute for professional mental health help. If you are struggling, distressed or require personalised advice, please reach out to your doctor or a licensed psychologist.See omnystudio.com/listener for privacy information.

He was an elite marathoner running 150 miles a week. A few years later, his SPECT brain scan looked comparable to 80-year-old patients with dementia. He was 22.Cameron George is the founder of Tru Kava and a member of the Kava Coalition. He has worked with physicians and researchers to modernize kava as a functional beverage category and has spent more than a decade studying plant pharmacology, GABA modulation, and nervous system recovery. In this conversation, Cameron explains the biochemical credit card model of synthetic drug dependency, why acetaldehyde — not ethanol — drives the effects of alcohol, and how traditional kava binds to GABA-A receptors without producing the depletion and tolerance seen with benzodiazepines. He describes how the kavalactone entourage effect enables reverse tolerance, the mechanism that allowed him to taper off benzodiazepines in under two months. Listeners learn the measurable impact of casual alcohol use on HRV and sleep architecture, the difference between real kava and US-market extracts, and the practical applications of kava for stress, focus, sleep, and alcohol-free social life.Cameron also shares his own collapse: the high-dose Adderall and benzodiazepines that nearly destroyed his nervous system, the years of multiple chemical sensitivity that followed, and the serendipitous phone call from a friend in Vanuatu that changed the trajectory of his recovery.This conversation is for anyone questioning the role alcohol plays in their performance, anyone who's been handed a prescription without answers, and anyone looking for a credible path back to a regulated nervous system.Cameron talks about:00:00 Why alcohol is a metabolic poison and acetaldehyde causes the buzz09:11 Biochemical credit cards: how synthetic substances drain your neurochemistry20:40 The Adderall and benzodiazepine prescription that broke his nervous system22:16 A SPECT brain scan comparable to 80-year-old dementia patients29:30 Autoimmune collapse, 10 grand mal seizures a day, and reacting to water31:33 The Vanuatu phone call that introduced him to traditional kava35:28 How kavalactones modulate GABA-A receptors37:10 Reverse tolerance: why kava heals the system instead of depleting it41:46 What hyper-sobriety, focus, and the kava afterglow feel like44:00 Why kava hepatotoxicity claims were debunked in 201446:30 Why traditional preparation beats kava extracts51:55 The 200 strains of kava and the vision to replace coffee cultureAdditional Resources✨ Follow Cameron George on Instagram: https://www.instagram.com/cameron.george_/ ✨ Learn more about Tru Kava: https://trukava.com ✨ Connect with Cameron George on LinkedIn: https://www.linkedin.com/in/cameron-george-0311aa185/ ✨ Follow Tru Kava on Instagram: https://www.instagram.com/trukava/ Visit My Clinic: Chara Health

Send us Fan MailA rare autoimmune disorder can feel invisible until it steals someone's movement, and stiff person syndrome is one of the starkest examples. We break down what's happening in the nervous system when GABA-driven “calm down” signals get disrupted by autoantibodies, why symptoms can escalate into severe spasms and rigidity, and why the condition has captured public attention through Celine Dion's story.Then we shift from symptoms to source: an experimental CAR T-cell therapy designed to eliminate the B cells that produce the harmful antibodies in stiff person syndrome. We walk through what a phase two clinical trial reported, including real-world changes like faster walking and fewer people needing walking aids, plus the caveats that matter for anyone following medical research such as side effects, small sample sizes, and unknown durability.Pet parents get a deep dive too. Chronic kidney disease in cats is common, progressive, and often detected late, so we cover a promising approach involving AIM protein and recombinant AIM therapy (RAIM) injections, including how researchers tracked toxins like indoxyl sulfate and what survival outcomes looked like over a year. Finally, plant scientist Dr. Vikram Baliga joins us to make botany feel urgent and strange in the best way, from ancient bristlecone pine “time capsules” to crown shyness and the science of how plants sense nearby competitors, plus a glimpse at nitrogen-fixing corn research that could reduce fertilizer dependence.Dr. Vikram's linksAll our social links are here!Support the showFor Science, Empathy, and Cuteness!Being Kind is a Superpower.All our social links are here!

Text Dr. Lenz any feedback or questions Gabapentin and Pregabalin Explained: Calming an Overactive Nervous System in Pain, RLS, Fibromyalgia, and SleepThe script explains gabapentinoids (gabapentin and pregabalin) as neuromodulators that “turn down” an overexcited central nervous system seen in central sensitization/nociplastic pain syndromes, helping conditions such as neuropathic pain, restless leg syndrome (RLS), fibromyalgia, anxiety, and sleep disruption. It clarifies they don't act on GABA receptors; instead they bind the alpha-2-delta-1 subunit on calcium channels, reducing calcium influx and release of excitatory neurotransmitters (glutamate, substance P, norepinephrine), lowering pain, restlessness, and anxiety. The script highlights guideline shifts making gabapentinoids first-line for chronic RLS due to minimal augmentation risk versus dopamine agonists, notes pregabalin's FDA approval for fibromyalgia (gabapentin used off-label), and emphasizes improved slow-wave sleep and restorative recovery. Practical guidance includes nighttime dosing, “start low and go slow” titration, side effects, off-label use, and the need for doctor supervision.00:00 Nervous System Overdrive01:41 Central Sensitization Explained03:52 What Are Gabapentinoids05:45 How They Work in Brain08:14 Restless Leg Syndrome Shift10:14 Fibromyalgia and FDA Approval12:05 Deep Sleep Healing Boost14:55 Nighttime Dosing Strategy17:04 Side Effects and Titration20:59 Off Label Uses and Kids22:49 Analogies and Key Takeaways24:51 Final Summary and Disclaimer Click here for the YouTube channel Support the showWhen I started this podcast and YouTube Channel—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope.  If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 29+ years as an MD.Please remember to talk with your doctor about your symptoms and care. This content doesn't replace per...

#317 I'm a degree-qualified naturopath with over 20 years of clinical experience, with a primary focus on complex gut health conditions — and in this video, I'm doing something I've never done before. I'm turning the lens on myself. I recently got my own gut microbiome tested, and I want to walk you through every single result. I didn't get tested because I had gut symptoms — my bowels are actually moving beautifully. I got tested because I'd been dealing with over a year of persistent rosacea and wanted to know: could what's happening in my gut be connected to what's showing up on my skin? I also wanted to show you exactly what this test looks like when it's interpreted by someone who does this for a living. We cover every section of the report — the pathogen panel, the diagnostic GI markers, microbiome diversity and richness, short-chain fatty acids, TMA, emerging metabolites, the species table, and more. I also share the result that was flagged as severely abnormal — and why, in context, it almost certainly isn't. This is what it looks like to use real data to motivate real change — not because something has gone terribly wrong, but because catching the trajectory early is the whole point. What we cover What makes shotgun metagenomics different from other stool tests The targeted pathogen panel — what it tests for and what my results showed Pancreatic elastase — the result that flagged severely low, and why context changes everything Lactoferrin, calprotectin, zonulin, secretory IgA, and faecal occult blood Microbial diversity and richness — what we're aiming for and why it matters Butyrate, acetate, propionate, and TMA — what they mean and how diet influences them Prevotella copri — nuanced, misunderstood, and more common in traditional diets than you'd think Emerging markers, including GABA, and why we need to hold them lightly Human DNA elevation — and why collection context explains it My action steps and why seeing this data now motivates me to act I'm Lynda Griparic, a degree-qualified naturopath with extensive experience in complex gut health conditions, including SIBO, IMO, and chronic constipation. Book a consultation or shop BetterMe Tea at lyndagriparic.com This content is for educational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health routine.

Join our FREE upcoming masterclass: Why Midlife Weight Gain Won't Budge A smarter way to use GLP-1s in midlife without wrecking muscle or metabolism When: April 30th 11 am PST Register here: https://coaching.karenmartel.com/glp1-masterclass Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full episode here: https://karenmartel.com/blogs/podcast/metals-amp-menopause-the-impact-of-heavy-metals-on-your-sex-hormones-thyroid-and-energy-and-how-to-properly-detox-them-with-dr-chris-shade  Itunes: https://podcasts.apple.com/us/podcast/metals-menopause-the-impact-of-heavy-metals-on-your/id1438772276?i=1000657503673 Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, continues to be the driving force of development and innovation. Dr. Shade's vast depth and breadth of knowledge, passion for healing, and intuitive understanding of chemistry and biology are reflected in Quicksilver Scientific's well-designed detoxification protocols, unique supplement delivery systems, and patented mercury speciation test. We'll talk with Dr. Shade in this episode about his revolutionary work with nanoparticle-based hormone formulations and how they've transformed the landscape of hormonal health. Dr. Shade also explains the delicate relationship between hormones, such as estrogen and progesterone, and the body's detox pathways. We hear about the dangers of heavy metals such as mercury and cadmium on health, critiquing traditional heavy metal chelation methods and exploring more effective modern protocols. In this episode we discuss: How Dr. Chris Shade's personal experience of seeing women with perimenopause influenced his focus on hormone therapy. Why nanoparticle-based hormone formulations revolutionize hormonal health and detoxification. Why nanoparticle delivery systems offer smoother detoxification and fewer side effects. How progesterone's effects on GABA receptors can promote calmness and relaxation. Why heavy metals like mercury, cadmium, and arsenic impact anxiety, fatigue, and thyroid function. How traditional chelation methods compare to modern protocols like EDTA and glutathione. Why ongoing detox efforts are crucial, especially for conditions like Lyme disease and insulin resistance. How high doses of lipoic acid can disrupt metal balance and glutathione levels. Why Dr. Shade dislikes Andy Cutler's chelation protocol and its impact on patients. How substances like cilantro and chlorella vary in effectiveness for natural chelation. What role heavy metals in vaccines may play in the development of autism. Why administering vaccines individually and during good health is important. Why hormone optimization is vital before starting detox treatments. How heavy metals like lead and cadmium can contribute to insulin resistance and hormone dysfunction. How environmental toxins and xenoestrogens may be linked to the rise of polycystic ovarian syndrome (PCOS).     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

 Guest: Cynthia Thurlow, NP — Author of The Menopause Gut | 2x TEDx Speaker In this episode:How a Morocco trip landed Cynthia in the hospital for 13 days — and what God showed her thereWhy your gut is the key longevity organ you've never heard ofThe gut-brain, gut-bone, and gut-ovarian axes — how it's all connectedWhy "I go to the bathroom every day" doesn't mean your gut is healthyWhy digestion starts in the brain — not your stomachHow stress spikes your blood sugar more than food doesSkin rashes, brain fog, and psoriasis as gut signals — not separate problemsShort chain fatty acids, sodium butyrate, and rebuilding the microbiomeWhy postmenopausal women need to stop thinking about their hormones in silosCynthia's non-negotiables: sleep, boundaries, fiber, HRT, and no alcoholResources: Free Midlife Gut Guide → http://themenopausegut.com/midlife-gut-guide?am_id=tabatha7584 The Menopause Gut Book → https://themenopausegut.com/?am_id=tabatha3589 All-In-One Microbiome Lift → shop.fasttofaith.com/product/gut-lift/ Use code PODCAST for 20% off"I will restore your health and heal your wounds, declares the Lord." — Jeremiah 30:1700:00 — So many women have lost hope — give them some right now 00:58 — Welcome back: spring break, nature, and God's goodness 02:38 — Introducing Cynthia Thurlow: author, 2x TEDx speaker 04:11 — Pain to purpose: the theme of Fast to Faith guests 05:35 — Why women still don't know this information 06:36 — Cynthia's personal journey: how it all started 07:34 — Morocco, food poisoning, and 13 days in the hospital 12:54 — God is doing good works — are you getting on board? 15:35 — Giving women permission to advocate for themselves 15:45 — Omega Lift: why omega-3s matter more than ever 18:30 — How Cynthia healed: 9 months carnivore, 18 months to vegetables 22:04 — Why you can't eat fiber when your microbiome is decimated 23:19 — Carnivore as therapeutic — not forever 24:00 — Digestion is a north-to-south process — it starts in the brain 29:19 — Sodium butyrate and rebuilding the microbiome 30:51 — Gut health affects serotonin, GABA, and dopamine 31:52 — Your gut health determines your longevity 35:39 — Genesis, the microbiome, and how God designed us 36:39 — Skin rashes and psoriasis as gut signals 38:34 — Healthy Her: catching the signals before they become crises 39:35 — Healing takes years — not weeks 40:21 — Blood sugar, cortisol, and the CGM lesson 42:05 — It took time to learn these boundaries 42:19 — Cynthia's non-negotiables: sleep, stress, fiber, HRT, no alcohol 47:41 Ready to stop trying harder and start healing smarter? Start with the $5 Faith Reset Challenge — your first step to regulating your nervous system, stabilizing your metabolism, and reconnecting with your identity in Christ through simple, faith-centered rhythms. This is where most women begin. 

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection

Welcome to this week's Midlife Minute episode. Today, I answer a question from a 55-year-old postmenopausal woman on HRT who still wakes up multiple times at night. I also explore the factors that tend to affect women's sleep in midlife and offer practical strategies for better sleep. IN THIS EPISODE, YOU WILL LEARN: How sleep apnea shows up differently in women than it does in men Why being constantly sympathetic dominant may interfere with your sleep How not eating enough protein, healthy carbohydrates, fiber, and healthy fats can spike your cortisol overnight How drops in progesterone and changes in estrogen can impact GABA and glutamate The importance of doing vagal exercise during the day and gearing down before bed  Some simple vagus nerve practices to support relaxation How alterations in progesterone and estrogen impact neurotransmitters My favorite supplement for supporting sleep, and adaptogenic herbs that buffer cortisol Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Links: 1. Sleep and sleep disorders in the menopausal transition (Research Link) 2. The Sleep Goddess Reveals the Truth About Sleep, Menopause & Hidden Sleep Disorders | A. Matsumura (YouTube)  3. Pulsetto (Affiliate link): Discount code: CYNTHIA

What if feeling better didn't have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn't what it used to be, and there's a constant sense of stress that doesn't seem to resolve. We walk through what's actually happening beneath the surface, why it can be so hard to break out of that pattern once you're in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What's keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn't always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn't have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Korrus, Timeline, BON CHARGE, BIOptimizers and Pique. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. (0:00) Introduction and guest Dr. Scott Scherer (3:31) Understanding the sympathetic spiral of doom (5:06) Symptoms and signs of sympathetic overdrive (7:10) Sympathetic activation, mitochondrial function, and stress (10:02) Mitochondria: their role and impact in the body (12:31) Stress, metabolic dysfunction, and their effects (17:43) Nervous system, mitochondria, and the cell danger response (21:25) Survival, stress, and breaking the sympathetic spiral (23:11) Contributors to stress: top-down and bottom-up (25:56) Mitochondria, microbiome, and medication impacts (29:38) Mitochondrial dysfunction and mental health (32:19) Limitations of parasympathetic activation and addressing root causes (36:46) How mitochondrial stress leads to fight-or-flight (37:52) Steps to break the sympathetic spiral and support mitochondria (42:41) Methylene blue: benefits, uses, and safety (50:35) Methylene blue as an MAO inhibitor and for chronic infections (57:17) Case studies, third-party testing, and Transcriptions' evolution (1:02:36) Parasympathetic edge, recovery, and the GABA system (1:07:44) GABA, supplements, and interventions for stress (1:12:23) Addressing root causes and methylene blue usage (1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem (1:19:49) OneBase Health, hyperbaric space, and final information

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if your brain is electrically "awake," you will stay "tired but wired."The "switch" I use to fix this is an amino acid called L-theanine. It crosses the blood-brain barrier to increase Alpha waves, which quiet the prefrontal cortex and stop overthinking. By boosting GABA and lowering glutamate, it prepares the brain for rest without the groggy "hangover" of traditional sedatives.To make this work, I follow a strict protocol: taking 400mg–1000mg about 45 minutes before bed on an empty stomach. I also protect my "Alpha state" by blocking blue and green "junk light" with TrueDark glasses, which prevents cortisol spikes that ruin sleep architecture. When you combine the right compounds with a dark, low-stimulation environment and consistent timing, sleep stops being something you chase and becomes something your body does automatically.Timestamps:00:00 – Introduction00:23 – How the Brain Enters Sleep01:00 – Why Most Supplements Fail02:15 – Beta Waves: The Sleep Blocker03:29 – Alpha Waves: The Sleep Gateway04:51 – The Amino Acid That Shifts Your Brain06:11 – Introducing L-Theanine06:48 – Common L-Theanine Mistakes08:02 – The Right Protocol09:34 – Light & Your Sleep Environment11:13 – Fixing Your Light Environment12:14 – The Full Sleep System13:59 – Putting It All TogetherThank you to our sponsors!AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices