Podcasts about Gaba

GABA for stress and anxiety GABA—gamma-aminobutyric acid—is a powerful inhibitory neurotransmitter that plays a major role in calming the nervous system. Dr. Mike and Dr. Crystal break down how GABA works, its impact on stress, anxiety, and brain waves, and what clinical research has revealed about its potential to improve sleep and reduce anxiety. They also explore natural sources of GABA, how to support its production in the body, and how it compares to other calming agents like melatonin and L-theanine. Whether you're curious about brain chemistry or just looking for natural ways to relax, this episode has you covered. #LELearn

Right now, someone is sitting across from a psychiatrist about to get a prescription for anxiety that has nothing to do with the real root cause. In this episode, Dr. Steven Noseworthy breaks down the hidden mechanism connecting blood sugar crashes and anxiety — not two separate problems, but one feedback loop.You'll learn why anti-anxiety medications leave more than half of patients with unresolved symptoms even after years of use, why GABA — the brain's main calming neurotransmitter — is actually a byproduct of energy metabolism, why oral GABA supplements can't cross the blood-brain barrier, and the surprising link between your balance system, your frontal lobe, and your ability to control anxiety.Key Topics:Why the DSM-5's anxiety categories don't explain what causes anxietyThe neuroendocrine immune supersystem behind anxietyHow the amygdala and frontal lobe act as an accelerator/brake systemWhy blood sugar crashes trigger the same cortisol/adrenaline cascade as real dangerWhy anxiety wakes you up between 1-3amHow GABA is made as a byproduct of energy metabolism (Krebs cycle → glutamate → GABA)The hidden link between balance/coordination problems and anxietyTimestamps:00:24 Introduction to the link between anxiety and blood sugar02:51 Anxiety diagnosis and treatment framing06:08 A systems view of anxiety07:03 How the brain regulates anxiety09:56 Blood sugar as an anxiety trigger13:16 Why anxiety can wake you at night14:31 Energy metabolism and GABA17:55 Balance, the frontal lobe, and anxiety19:34 Key takeaways and next stepsDr. Noseworthy runs a virtual functional medicine practice based in Florida, working with women across the US and internationally who are untangling blood sugar, adrenal, thyroid, and gut issues that show up as anxiety. Work with Dr. N 1-on-1 to find your unique Root Cause Disruptors and define your own personal Journey, visit https://www.drnoseworthy.com/contact to request an initial consultation.LINKS▶️ See the full video version on YouTube.

Wondering how to lower cortisol naturally? Nurse Doza walks through five practical habits that support a healthier cortisol rhythm: managing everyday stress, getting morning sunlight, cutting screen time at night, using diaphragmatic breath work, and supplying the adrenal glands with the nutrients they run on. The goal is not crushing cortisol. The goal is rhythm, high when it should be high and low when it should be low. Featured Product Zen (Stress Relief) by MSW Nutrition, $69 If you are running on caffeine and adrenaline, your body is burning through the exact nutrients it needs to keep cortisol on a healthy rhythm. Zen is built to put them back. It pairs 125 mg of adrenal glandular tissue, sourced from Argentinian bovine for purity, with four standardized adaptogens: Asian ginseng, rhodiola, eleuthero, and schisandra. It also delivers vitamin C, vitamin B6, and pantothenic acid (B5), the nutrients concentrated in adrenal tissue and used up fastest under sustained demand. Most stress formulas give you one botanical. Zen runs four, in one capsule taken twice daily, so you are not juggling a shelf of bottles. Supports the body's adaptogenic response Supports healthy adrenal physiological function Supports energy production and stamina Supports the body's response to everyday stress

GABA for stress and anxiety GABA—gamma-aminobutyric acid—is a powerful inhibitory neurotransmitter that plays a major role in calming the nervous system. Dr. Mike and Dr. Crystal break down how GABA works, its impact on stress, anxiety, and brain waves, and what clinical research has revealed about its potential to improve sleep and reduce anxiety. They also explore natural sources of GABA, how to support its production in the body, and how it compares to other calming agents like melatonin and L-theanine. Whether you're curious about brain chemistry or just looking for natural ways to relax, this episode has you covered. #LELearn

Are you exhausted from over-giving and over-doing? Do you tend to look to others for validation or lean into people-pleasing behaviors? If so, you're in solid company. From childhood forward, many of us learn to tend to others' needs to feel valuable and worthy. And from my experience, these hardwired habits can foster perfectionism, enmeshment, and dependency--and even open the door to being exploited by thoughtless or self-serving people. Yet I've found that small changes over time can foster the awareness and inner strength you need to create healthy habits and set yourself free. Today, we're joined by a fabulous guest who specializes in helping others gain self-worth from within--instead of from others.Topics discussed include emotional outsourcing, perfectionism, self-care, self-love, habit change, midlife crisis, perimenopause, menopause, life changes, role changes, codependency, red flags, neurolinguistics, GABA, boundaries, marriage, children, parenting, healthy relationships, reciprocity, mutuality, and grief.Please note that this episode contains sensitive material; listener discretion is advised.Emergency Assistance Details: If you or someone you know needs immediate support, please call your emergency services. In the US, 24/7 help is available by calling "911," "988" (Suicide and Crisis Hotline), or SAMSA (Substance Abuse and Mental Health Services Administration) at 1-800-662-HELP (4357). As applicable, additional resources may be provided in the show notes.Non-Emergency Online Mental Health Information: https://www.nami.org/support-education/nami-helpline/and https://odphp.health.gov/myhealthfinder/healthy-living/mental-health-and-relationshipsIMPORTANT DISCLAIMER: No expert is offering medical or psychological direction or advice; the content is purely informational in nature. Please consult your physician or healthcare provider before undertaking any new regimen or procedure.Connect with Dr. Carla Manly:Website: https://www.drcarlamanly.comInstagram: https://www.instagram.com/drcarlamanly/Twitter/X: https://www.twitter.com/drcarlamanly/Facebook: https://www.facebook.com/drcarlamanlyLinkedIn: https://www.linkedin.com/in/carla-marie-manly-8682362b/YouTube: https://www.youtube.com/@dr_carlamanly_imperfect_loveTikTok: https://www.tiktok.com/@dr_carla_manlyBooks by Dr. Carla Manly:Joy From Fear: Create the Life of Your Dreams by Making Fear Your Friend Date Smart: Transform Your Relationships and Love Fearlessly Aging Joyfully: A Woman's Guide to Optimal Health, Relationships, and Fulfillment for Her 50s and Beyond The Joy of Imperfect Love: The Art of Creating Healthy, Securely Attached Relationships Imperfect Love Relationship & Oracle Card Deck by Dr. Carla Manly:Etsy AmazonConnect with Beatriz Victoria Albina:Website: https://beatrizalbina.com/Instagram: https://www.instagram.com/beatrizvictoriaalbinanp/?hl=enFacebook: https://www.facebook.com/beatrizvictoriaalbinanpLinkedIn: https://www.linkedin.com/in/beatrizvictoriaalbina/Additional Resources:End Emotional Outsourcing: https://beatrizalbina.com/book/Love the show? Subscribe, rate, review, and share! https://drcarlamanly.com/

In this Supplement Ingredient Series episode, Nurse Doza makes the case for the B vitamin nobody talks about: vitamin B6. Everyone knows B12 — the pills, the injections, the whole routine — but B6 is the cofactor your body leans on to build serotonin, dopamine, and GABA, the neurotransmitters behind mood, focus, and steady daytime energy. He covers who tends to run low, why intake alone doesn't guarantee good status, and where an adaptogen-plus-adrenal formula like Zen fits in. FEATURED PARTNER Zen (Stress Relief) by MSW Nutrition is the formula Nurse Doza reaches for when the B6 conversation turns practical. Each capsule delivers 15 mg of vitamin B6 as P5P — the already-active form your enzymes can use directly — alongside 125 mg of bovine adrenal gland (Argentina) and a five-botanical adaptogen blend: rhodiola, Asian ginseng, eleuthero, schisandra, and licorice, plus vitamin C and 150 mg of pantothenic acid. It's built to support the body's adaptogenic response to everyday stressors and support energy production and stamina.

【迷走大學】 X 【豐傑生醫】 聯手打造上班族後勤支援最佳組合！ 【712D益生菌-克菲爾PLUS】【20倍專利黑蒜精華】【酵母鋅+牛磺酸】【芝麻素+GABA】 團購開跑！2026/8/21-8/31 中午12:00 團購連結：https://fjb100.co/college (一定要在這個連結下單才有專屬優惠唷) 業務連絡:meisouniv@gmail.com 【脫口秀 演出購票】https://comedyclub.kktix.cc/events/meisouniv2026 ▽ YouTube 【迷走大學】https://www.youtube.com/@meisouniv 【迷走大學魯肚絲校區】https://www.youtube.com/@meisoludus ▽ 政治內幕《渣報》 → https://www.pressplay.cc/jiabo 【線​上課程】 ▽ HaHow平台（有六門課） → https://hahow.in/@lidance ▽ Pressplay平台（有五門課） → https://www.pressplay.cc/meiso -- Hosting provided by SoundOn

【迷走大學】 X 【豐傑生醫】 聯手打造上班族後勤支援最佳組合！ 【712D益生菌-克菲爾PLUS】【20倍專利黑蒜精華】【酵母鋅+牛磺酸】【芝麻素+GABA】 團購開跑！2026/8/21-8/31 中午12:00 團購連結：https://fjb100.co/college (一定要在這個連結下單才有專屬優惠唷) 業務連絡:meisouniv@gmail.com 【脫口秀 演出購票】https://comedyclub.kktix.cc/events/meisouniv2026 ▽ YouTube 【迷走大學】https://www.youtube.com/@meisouniv 【迷走大學魯肚絲校區】https://www.youtube.com/@meisoludus ▽ 政治內幕《渣報》 → https://www.pressplay.cc/jiabo 【線​上課程】 ▽ HaHow平台（有六門課） → https://hahow.in/@lidance ▽ Pressplay平台（有五門課） → https://www.pressplay.cc/meiso -- Hosting provided by SoundOn

【迷走大學】 X 【豐傑生醫】 聯手打造上班族後勤支援最佳組合！ 【712D益生菌-克菲爾PLUS】【20倍專利黑蒜精華】【酵母鋅+牛磺酸】【芝麻素+GABA】 團購開跑！2026/8/21-8/31 中午12:00 團購連結：https://fjb100.co/college (一定要在這個連結下單才有專屬優惠唷) 業務連絡:meisouniv@gmail.com 【脫口秀 演出購票】https://comedyclub.kktix.cc/events/meisouniv2026 ▽ YouTube 【迷走大學】https://www.youtube.com/@meisouniv 【迷走大學魯肚絲校區】https://www.youtube.com/@meisoludus ▽ 政治內幕《渣報》 → https://www.pressplay.cc/jiabo 【線​上課程】 ▽ HaHow平台（有六門課） → https://hahow.in/@lidance ▽ Pressplay平台（有五門課） → https://www.pressplay.cc/meiso -- Hosting provided by SoundOn

In this episode, Christian Poulos, MD, shares his journey from powerlifting enthusiast to medical professional focused on biohacking and optimizing human health. He discusses neuroscience, strength training, nutrition, supplements, and the future of medicine.Chapters00:00 Introduction and Christian Poulos' background00:41 Christian's journey from powerlifting to medicine02:04 Neuroscience and neural recruitment in strength training05:43 Understanding biomechanics and muscle recruitment07:34 Body composition experiments and best physique09:59 Common mistakes in muscle building and fat loss11:27 Hierarchy of variables impacting responsiveness to training14:20 Role of carbohydrates and nutrition strategies16:16 Blood markers and personalized nutrition19:54 Foods for natural testosterone support22:46 The importance of gut health and fiber23:14 Supplements for testosterone and hormonal health27:29 Effects of testosterone on physiology and psychology28:50 Long-term effects of DHT and hair loss32:03 DHT, GABA, and anxiety33:25 Natural approaches to DHT management35:07 Amino acids and neurotransmitter support37:31 Staple supplements: vitamin D, magnesium, omega-3s39:15 Gut health, probiotics, and microbiome41:00 Passions in medicine: peptides and liver detoxification46:40 Future pathways in neuroscience and nootropics49:19 Understanding dopamine, serotonin, and receptor targeting50:35 Morning routines and health hacks for productivity54:19 Supporting mitochondrial health and energy production55:58 Closing remarks and where to find ChristianThe information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. The products presented and discussed in this podcast are explicitly only relevant to those who reside in the US. The statements and discussions held within this episode, are NOT approved by the TGA. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full episode. Listen on iTunes. Angela is an award-winning Nutritionist, Health & Performance Coach, Keynote Speaker and Host of The High Performance Health Podcast. A former corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela regularly gives keynotes to large fitness, health and wellness events She also delivers Health Optimisation and Performance Workshops to large multinational corporations with a strong focus on women's health and burnout prevention. Angela brings us through her vast knowledge of midlife mental health, focusing on the hormonal shifts that many women experience during perimenopause and menopause. We explore how a drop in key hormones like serotonin and GABA can exacerbate depression and anxiety. Angela shares her personal journey from a high-powered corporate lawyer to a health advocate, revealing the strategies she used to harmonize her hormones and prevent burnout. Together, we discuss mental health strategies that you can easily implement, the challenges of balancing career and motherhood, and the importance of self-kindness and resilience during midlife transitions. In this episode: Why serotonin and GABA drops can amplify mood disorders in midlife women. Angela's transition from a corporate lawyer to a health performance coach. How Angela battled PCOS, endometriosis, and prenatal and postnatal depression. Why seeking help for mental health issues is crucial, especially during midlife. How Angela harmonized her hormones and prevented burnout. The importance of mindfulness and simple, present-focused strategies for mental well-being. Why balancing motherhood and a demanding career requires emotional resilience. How infant health issues often add to maternal stress and isolation. Strategies for managing depression and anxiety through mindfulness and thought pattern changes. How past traumas resurface during midlife and require new therapeutic approaches. Why self-awareness is essential for overall well-being in midlife. The significance of "mastering the mirror" to align your current self with future goals. How over-optimization of health strategies can lead to additional stress. Why HRV monitoring is important for stress management and recovery. How practical techniques like breathwork and micro-recoveries can improve HRV. Why maintaining physical health and mental engagement is crucial as we age. The importance of self-kindness and passing on positive attitudes to future generations. How embracing aging involves maintaining youthfulness and well-being. The role of healthy habits in overall well-being and longevity.   Visit Angela's website.     Sponsors Head to cozyearth.com and use my code HORMONE for an exclusive 20% off.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Jaume Segalés y los expertos de Mundo Natural hablan sobre el GABA

It's Just Bodybuilding Podcast collab  ⁨@ThinkBIGBodybuilding⁩  APR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle (code nyle)00:00:00 Intro00:03:07 Why AJ Avoids Bodybuilding Podcasts00:06:40 Trauma, Transparency & Bodybuilding00:09:28 Retard Maxing & The Healing Spectrum00:12:13 Trauma's Toll on the Nervous System00:17:09 Mind-Soul Connection & Identity00:23:20 AJ's 2013 Health Crisis: Ulcerative Proctitis00:25:47 Finding True Identity00:30:48 GABA, Glutamate & Cycle Toxicity00:36:10 Peptide Protocols: Selank & Box Breathing00:38:20 Healing Neuroinflammation: Cerebrolysin & Cortexin00:41:40 Dopamine Resets & Nicotine Patches00:45:45 Sleep Struggles & The Danger of Anticholinergics00:48:14 DORAs: The Future of Sleep Medication00:52:53 Genetic Testing, ApoE4 & Thyroid Health00:57:46 Overcoming Ego & Coaching Evolution01:08:34 AJ's Best Client Preps01:13:13 The Carrot Cake Peaking Strategy01:14:55 Peaking Hassan Mostafa & RAAS Manipulation01:21:21 The Art of Peaking: Sodium & Potassium01:25:21 Jay Cutler's Mentorship Lessons01:26:38 Health-First Prep & Low-Dose PEDs01:31:58 The Backstage Mindset & Self-Belief01:34:35 PED Risk Management & Pulling Oils Early01:41:03 Honoring Matt Porter & John Meadows01:42:52 Supersaturation Days vs. Cheat Meals01:44:39 The Circadian T3 Method01:47:15 Gut Healing & Stomach Acid01:51:53 Leg Training Volume & Frequency01:53:49 Training Lagging Muscle Groups01:55:04 Growth Hormone Timing01:56:54 Fixing Lipids & PCSK9 Inhibitors02:00:45 Clearing Acne & Gyno02:02:26 PEDs & Retinal Damage02:04:21 Health Optimization on a Budget02:05:43 Final Message

TJ starts this Friday program talking about Pre-season football, then gets a mouthful from Carlyle bursting his bubble. Then tripping in the house, TJ and Gaba go back and forth on this issue. Lastly Merritt Allen joins TJ to talk about the USS Abraham Lincoln which is in the Gulf. All this and more on News Radio KKOB See omnystudio.com/listener for privacy information.

The new vaccine schedule recommendationsMy urologist is giving me grief that my vitamin D level is too highWhich nattokinase do you recommend to treat long covid?Is the vitamin K in your bone protocol different from the heart protocol?What about methylated B vitamins for brain vs. heart health?

Jay Gunkelman has read more than half a million brain scans — and this week he and host Pete Jansons open the Brain Bar with a claim that sounds impossible: your brain is lying to you about time itself. In the experiments Jay walks through, a person's body reacts emotionally to an image seconds BEFORE a random generator has even chosen which image they'll see. From there the panel takes your live questions across the map: the anxiety medications that quietly dig a two-year hole, kids told to remove part of their brain for epilepsy who turned it around another way, what autism, ADHD and addiction secretly share on an EEG, and how your alpha rhythm changes across your whole life. Plus Joshua Moore's intro to QEEG phenotypes — and Josh's own story of beating "incurable" torticollis after Walter Reed told him he'd end up in a wheelchair.

Anxiety in perimenopause isn't a mood problem — it's a clearance problem. Liz Roman and Becca Chilczenkowski break down COMT, GAD1 and FUT2: the three genes that decide how fast you clear adrenaline, whether you can build GABA, and whether your gut can grow the bacteria that make it. Plus why L-glutamine can make anxiety worse, why oral GABA mostly doesn't work, the lab markers hiding in plain sight on your standard panel, and why "your genes didn't change — your estrogen did." *** CONNECT:

Dr. Kyle Bills joins the show to explore the neuroscience of dopamine, anxiety, addiction, and the emerging role of non-pharmacological interventions in supporting brain health. Together, we discuss how targeted vibrational stimulation may influence neurological pathways involved in reward, craving, and behavior and how this technology could complement existing therapies to support more effective, personalized care.We dive into:How dopamine and GABA interact within the brain's reward and learning pathwaysWhy dopamine is more than a “feel-good” neurotransmitter and how it shapes behaviorThe neuroscience behind cravings, addiction, and withdrawalHow targeted vibrational stimulation may influence dopamine-related brain circuitryWhat clinical research is showing about anxiety and substance use recoveryHow non-pharmacological interventions may complement cognitive behavioral therapy and other standards of careThe potential role of this technology in supporting sleep, cravings, and behavioral changeThe future of neuroscience-driven, non-pharmacological approaches to mental and neurological health

IN THIS EPISODE   When we feel anxious, down, or just not like ourselves, we usually assume something in our life is to blame.   But what if sometimes the problem isn't your life… it's that your brain is missing a crucial nutrient?   In this episode of the ReThink Health Podcast, I sit down with Julia Ross, a pioneer in the nutritional use of amino acids for mood, cravings, eating disorders, and addiction. After more than 40 years of clinical work, she's helping answer some fascinating questions about the connection between protein, brain chemistry, and how we feel. You'll hear how amino acids like DLPA, GABA, tryptophan, tyrosine, and glutamine interact with neurotransmitter systems tied to mood and appetite. Julia also explains why cravings for foods like chocolate, sugar, bread, and cheese may offer clues about what's happening in the brain… and why getting enough high-quality protein is such an important nutritional foundation.   It's a fascinating look at mood and cravings from a completely different angle: not just what's happening in your life, but whether your brain has the raw materials it needs to function at its best.   You'll learn: The difference between a "true mood" and a "false mood" How specific amino acids support neurotransmitters involved in mood, calm, focus, and pleasure Why DLPA may support endorphin activity and emotional well-being How GABA, tryptophan, tyrosine, and glutamine each play different roles Why certain food cravings may offer clues about your brain chemistry How ultra-processed diets and low protein intake may affect amino acid availability How to tell exactly which amino acids you need for your most vibrant health If you've ever wondered why you can have a good life and still not feel good, this episode offers a fascinating new way to think about the connection between food, brain chemistry, and mood.   VALUABLE RESOURCES Paleovalley 100% Grass Fed Bone Broth Protein >>> Give your body the high-quality protein and naturally occurring amino acids it needs with Paleovalley 100% Grass Fed Bone Broth Protein for up to 20% OFF!   BIO   Julia Ross is a pioneer in the nutritional use of amino acids for mood problems, eating disorders, and addiction, with more than 40 years of clinical experience. Her work began in addiction treatment in the late 1970s and evolved as emerging neuroscience revealed how specific nutrients could influence the brain systems involved in mood, cravings, focus, and addictive behavior.   She is the author of The Diet Cure, The Mood Cure, and The Craving Cure and has directed clinics since the early 1980s. Today, her clinic also works virtually, allowing clients to trial amino acids with professional guidance from home.   THANKS FOR LISTENING! Thanks so much for joining us this week! Have feedback or a question? Email us at support@paleovalley.com—we'd love to hear from you. If you enjoyed this episode, please share it with someone who might benefit from the information. Following the ReThink Health Podcast on YouTube, Spotify, or iTunes helps us reach more people who need to hear this and keeps you updated on new episodes. Likes, subscribes, ratings and reviews are incredibly helpful and deeply appreciated—we read every single one! Let's spread this knowledge and help others together. See you next time! Click below to follow on YouTube, Spotify or iTunes:  

If you've suddenly become more forgetful, easily overwhelmed, anxious, irritable, or feel like your brain simply isn't working the way it used to, there's a physiological reason.Perimenopause isn't just about periods, hot flashes, or fertility. It's a major neurological and metabolic transition. Estradiol and progesterone influence your brain, nervous system, neurotransmitters, sleep, mood, memory, focus, and even how you respond to stress. When those hormones become unpredictable, your brain has to adapt too.You'll learn:Why perimenopause can feel like "PMS on steroids"How fluctuating estradiol affects memory, focus, mood, and motivationWhy word-finding, brain fog, anxiety, and overwhelm can suddenly show upHow progesterone and GABA influence that feeling of calmWhy these symptoms have real physiological explanationsSix foundational areas that can support your brain and body through this transition: nutrition, exercise, sleep, stress regulation, connection, and reducing toxin exposureUnderstanding what's happening won't make every symptom disappear, but it can replace some of the confusion with context—and help you better support your body through this season.I'm also sharing details about our FREE community screening of The M Factor II: Before the Pause on August 29 in the Jacksonville area. Join us as we continue breaking the silence and creating better conversations around perimenopause.Register through the link in the show notes.I know it's not that easy, but it really is that simple.RSVP Now to secure your seat at the screening of M Factor II: Before The PauseCheck out the Facebook Event: M Factor II: Before The PauseSupport the showGet Weekly Health Tips:  thrivehealthcoachllc.comJoin the Thrive Collective Facebook groupLet's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.comPodcast Produced by Virtually You!

A rash baffled 25 years of dermatologists. It disappeared in a week once Dr. Steven Zodkoy traced it to a childhood memory. Here's what that case, and the concept of a "biofilm," has to do with your migraines and your bladder. Dr. Chris Motley sits down with Dr. Steven Zodkoy, a chiropractor and applied kinesiologist who became the first in his field to pass the American College of Nutrition exam, a credential previously reserved for MDs and PhDs. Thirty-five years into practice, Dr. Zodkoy specializes in the patient conventional medicine gave up on: the migraine sufferer, the "recurring UTI" patient who never actually had a UTI, the chronic fatigue case with a normal bloodwork panel. His framework rests on one idea most doctors do not test for: the biofilm, a sticky protective layer that bacteria, viruses, mold, and parasites lay down to hide from the immune system and from treatment. Once one pathogen builds a biofilm, Zodkoy argues, it invites others in, which is why a "cured" infection so often resurfaces as something else entirely, chronic sinusitis becoming Lyme-like fatigue, a bladder infection becoming a lifetime of unexplained pelvic tightness, a resistant childhood strain becoming an adult autoimmune diagnosis.  Key Takeaways Biofilms are why a "cleared" infection keeps coming back as something else. A biofilm is the mucous-like shield a bacterium, virus, parasite, or mold colony builds to hide from the immune system and from antibiotics. Once it's there, he says, it invites other pathogens to shelter in it too, which can explain why chronic sinusitis, Lyme-linked fatigue, and mold exposure so often show up in the same patient.  Interstitial cystitis is frequently a tight-bladder problem being treated as a recurrent UTI. Dr. Zodkoy's read: stress and anxiety tighten the bladder, it never fully empties, and what's left behind gets infected, so the antibiotic treats a symptom while the muscle stays tight and the infections keep returning. His protocol adjusts the pelvic floor and pubic symphysis, then layers in biofilm-breaking supplements and emotional work.  A 25-year rash resolved after one round of Neuro-Emotional Technique tied to an age-seven memory. Every physical test on this patient, mold, yeast, parasites, heavy metals, came back clean. Emotional testing didn't.  His migraine protocol runs liver support first, nervous system second, emotional work third, in that order, on purpose. Dr. Zodkoy's 1992 theory ties migraines to a slow-functioning liver overloaded by chemical exposure, hormones, or diet. He walks us through his 8-week liver protocol, 16 weeks including autonomic nervous system support, and a 96% success rate once emotional work is added. You cannot do deep detox or trauma work on a nervous system that has nothing left. There's no point moving to detox, biofilm-clearing, or emotional release until a patient's self-rated energy crosses roughly 50 to 60 out of 100.  [00:00:00] Cold open: migraines, interstitial cystitis, chronic fatigue, and the biofilm nobody explains  [00:02:02] Origin story: "doctor, lawyer, doctor" and practicing three months before 25  [00:04:04] Why he became a nutritionist first: the autonomic nervous system as the missing piece  [00:06:08] Finding a hidden emotion: the six-minute visit versus a real history  [00:09:37] The HPA axis toolkit: DHEA, GABA, adaptogens, and a gut bacterium built for stress  [00:11:27] NET, emotion code, and generational trauma: "it doesn't have to be real, it has to be believed"  [00:14:36] The 25-year rash: a muscle test, a forgotten age seven, and a mother's confession  [00:19:04] Migraines: the 1992 liver theory, the 80/20 split, and a claimed 96% success rate  [00:23:43] Interstitial cystitis is not a UTI: the tight bladder nobody is treating [00:27:06]  Killing the biofilm: natokinase, antimicrobials, and cranial electrotherapy stimulation  [00:31:29] The sympathetic-parasympathetic seesaw, and why healing collapses without it  [00:34:59] The "oomph" scale: testing cortisol at home and in the office  [00:36:27] The protocol in order: glandulars, adaptogens, and parasympathetic support, dosed on purpose  [00:43:30] Chronic fatigue, sinus biofilms, and the "house party" that becomes Lyme, EBV, and mold  [00:47:19] Parasites in America, and the TG/HDL ratio he says predicts heart risk  [01:00:02] Closing: where to find Dr. Zodkoy, and a teed-up follow-up on the healthcare system Resources Mentioned Tools & Products Biofilm Clear: Zodkoy's stated favorite combination product for breaking down biofilms, made up of natokinase, serrapeptase, lumbrokinase, and bromelain. He describes dosing at 2000 IU for patients under 50 and up to 4000 IU for patients over 50 with abnormal bloodwork. CP2305 (referenced in audio as "PC2305"): a Lactobacillus gasseri probiotic strain studied for stress and HPA-axis effects. True Laser: a home low-level laser device Zodkoy places over the vagus nerve. Cranial electrotherapy stimulation (CES) units: clip-on-the-ear devices Zodkoy uses for anxiety, sleep, depression, and (with pads placed over the bladder) interstitial cystitis relief. Adrenal glandular products (brand examples given: Adrenal Complex from Designs for Health, Adrenal from Orthomolecular, Cortex from Thorne Research), used at a fraction of label dose, one pill in the morning only, per Zodkoy's protocol. Adaptogens referenced: ashwagandha, holy basil, rhodiola, cordyceps. • Nervous-system support referenced: DHEA, L-theanine, GABA, phosphatidylserine, adrenoglandulars. Antimicrobials referenced for biofilm-associated infections: berberine, olive leaf, oregano. Nutrients referenced for liver-support migraine protocol: B vitamins, glutathione, NAC. Concepts referenced: HPA axis (hypothalamus-pituitary-adrenal): the stress-response pathway Zodkoy targets before any other intervention. Applied kinesiology: manual muscle testing Zodkoy uses to distinguish emotional, physical, biochemical, parasitic, fungal, or toxic causes of a symptom. NET (Neuro-Emotional Technique), Emotion Code, Body Code: hands-on techniques used to locate and release stored emotional triggers. Sympathetic and parasympathetic nervous system balance: the "seesaw" framework underlying his treatment sequencing. • Triglyceride-to-HDL ratio: Zodkoy's preferred cardiovascular risk marker over total cholestero Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------  Follow Doctor Motley! Instagram TikTok Facebook Website Follow Dr. Steven Zodkoy https://www.instagram.com/drstevenzodkoy/ ------  *You can get cell support in gummy form: Mitopure now starts at $79, when you go to timeline.com/DRMOTLEY. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15

Send us Fan MailYou can look “fine” and still be struggling with alcohol. If you've ever held it together on the outside while quietly worrying about sleep, anxiety, confidence, or how often you're thinking about that next drink, I'm speaking straight to you.I'm Meg, and I'm opening this podcast with a topic that keeps people stuck for years: the stigma around the word “alcoholic”. I share why I don't use that label for my own experience, what Alcohol Use Disorder (AUD) actually means, and why the all-or-nothing idea of “either you're an alcoholic or you're fine” doesn't match real life. We talk about the grey area so many people live in: setting rules, promising “just one”, waking at 3am with a racing heart, and still convincing yourself it can't be a problem because you're high functioning.I also break down the science in plain language: how alcohol affects GABA, dopamine, and stress hormones like cortisol, why it can feel like instant relief, and why that relief comes with a rebound effect that feeds anxiety and cravings. Most importantly, we shift from shame to curiosity with better questions: Is alcohol helping me become the person I want to be? What is it costing me? How would my life feel without it?If you've been wondering whether your drinking is bad enough to change, take this as your permission to stop waiting. Follow the podcast, leave a review, share it with someone who's been quietly wondering too, and reach out if you'd like a free 30 minute chat via the link in the show notes or at meganwebb.com.au.https://auditscreen.org/ https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/understanding-alcohol-use-disorderhttps://my.clevelandclinic.org/health/diseases/3909-alcoholismhttps://www.nmhealth.com.au/health-wellbeing/helpful-articles-resources/how-alcohol-works/ Contact Meg: Website: https://www.meganwebb.com.au/Facebook: https://www.facebook.com/profile.php?id=61579436511475Instagram:https://www.instagram.com/meganwebbcoaching/Link to FREE discovery call with Meg:  https://calendly.com/glassfulfilled   

You can fall asleep fast, exhausted the second your head hits the pillow, and still be wide awake by 2am with your mind racing and no idea why. Maybe you're waking up drenched in sweat, assuming it's a hot flash, when it's actually something else entirely. In this episode, I'm breaking down the fifth S in the 6S Method, Sleep, and why it might be the missing piece even when you're doing everything else right.IN THIS EPISODE, YOU'LL LEARN:Why all six S's work like an overflowing bucket, and why sleep can undo every other piece of the puzzleMy own story of waking up drenched in sweat at 2-4am for months, and what was actually causing itWhy night sweats don't always mean hot flashes, and how poor detoxification can show up as sweating at nightHow a dysregulated nervous system keeps you "sleeping with one eye open," even after eight hours in bedWhy blood sugar instability during the day causes cortisol to wake you up at nightThe role progesterone and GABA play in falling asleep and staying asleep, and why that changes in midlifeWhy sleep is when your body actually burns body fat, and what happens when you don't get enough of itThe circadian rhythm basics that set the stage for better sleep, starting with how you wake up in the morningTIMESTAMPS: 00:00 — Introduction: Sleep, the 5th S in the 6S Method 02:19 — Why the six S's flow into each other like an overflowing bucket 04:37 — Melissa's story: gaining 10 pounds out of nowhere despite doing everything "right" 07:28 — Why we don't sleep well in midlife, starting with the nervous system 09:45 — Sympathetic vs. parasympathetic sleep, and "sleeping with one eye open" 11:06 — How unstable blood sugar during the day triggers cortisol at night 13:09 — Progesterone, GABA, and why midlife sleep gets harder 16:34 — Detoxification, poor gut health, and night sweats explained 17:33 — Why sleep is when your body actually burns body fat 20:44 — Circadian rhythm basics: eating within an hour of waking, morning workouts 23:02 — The cortisol and melatonin relationship, and winding down in the evening 26:15 — Sunlight, screens, and blue light before bed 29:31 — How the Strategy piece of Well Nourished (labs) supports better sleep 31:51 — Well Nourished waitlist details, enrollment guarantee, and what's next

I think the title says it all.See omnystudio.com/listener for privacy information.

TJ & Gaba & Bears, oh my!See omnystudio.com/listener for privacy information.

Pumpkin Pest Problem? More like an opportunity! Olive Oil or air fryer -- Squash Bug give that satisfying & nutritious crunch.See omnystudio.com/listener for privacy information.

☎️ Book Your COACHING INQUIRY Call: https://calendly.com/d/386-k9q-4cg/coaching-inquiry-call-zoom☎️ Book Your COMPLEMENTARY CONSULTATION and CALORIE CALCULATION Call: https://calendly.com/d/2p8-mxx-dgf/free-consultation-call-zoom⁠⁠⁠⁠⁠⁠➤ Bloating, Brain Fog & Weight Gain — The Truth About Estrogen Detox | MMP Ep. 299: https://youtu.be/RAta9uC_E-k➤ Top Foods to Lower Inflammation and Accelerate Fat Loss | MMP Ep. 318: https://youtu.be/1Hsa0pmLTVQ➤ Cortisol + Inflammation Grocery List: https://www.vitalityoet.com/cortisol-grocerylistYou were told progesterone would help you sleep, calm your anxiety, and support your hormones through perimenopause and menopause. So why do you feel WORSE?In this episode of the Metabolism and Menopause Podcast, Stephanie Crassweller breaks down the two metabolic pathways your body sends progesterone down — the alpha pathway (which produces the calming neurosteroid allopregnanolone) and the beta pathway (which produces inactive metabolites that do nothing for your brain, mood, or sleep). She explains why standard blood work cannot see which pathway your body favors, why the DUTCH test is the missing piece, and what inflammation, cortisol, thyroid, insulin resistance, and liver congestion have to do with whether progesterone helps you or hurts you.If you started progesterone and feel worse — this episode is for you.What you'll learn:

What if the condition you've been managing for years is actually a deficiency nobody tested you for? Karen "Zuzu" Armes had her first seizure around age five. By 21 she was on three medications and carrying a bell to warn people when the next one was coming. Then she got pregnant, refused to expose her daughter to those drugs, and used food to taper off all three. She has been seizure-free for close to 40 years, and she now teaches what she learned to more than 45,000 people worldwide. Meet our guest Karen "ZuZu" Ziemer Armes is a holistic health educator, author, and speaker who co-founded Holistic Health Educators and Lilly Fields Retreat Center. She reversed her own epilepsy, scoliosis, and arthritis through holistic strategies, has delivered more than 2,500 seminars, and written four health books. Her work focuses on gut and cellular healing, sustainable energy, and integrative longevity. She describes herself as a kitchen hacker rather than a biohacker. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Most seizure activity traces back to a GABA deficiency, not an unexplained neurological disorder GABA is made primarily in the digestive system, and requires both an adequate pH and a diverse microbiome You carry 70 to 90 trillion bacteria, and Armes puts the beneficial share above 95% Your body cannot break down fiber at all, so the diversity of plant fibers matters more than the total amount Amino acids build proteins and proteins build enzymes, meaning one missing amino acid halts everything downstream Minerals are the single category the body cannot manufacture, which is why she covers them first Biofeedback units range from about $149 a month to $30,000, but the practitioner reading them matters more than the hardware Dietary change shows in the bloodstream within three days, though clearing dairy and gluten from the cells takes about three months Episode highlights 02:21 The GABA discovery that ended 3 medications 05:53 The hand sanitizer problem nobody talks about 14:17 Your body's pharmaceutical factory 20:21 Why "fortified" on a label is a red flag 29:16 What biofeedback actually is 42:07 The 4 changes that cost nothing 59:04 The food and emotion frequency chart Links Watch it on YouTube: https://youtu.be/V-MgexRjb5c Full episode show notes: https://outliyr.com/271  Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In part one, Dr. Liz Bartman and I broke down why PMDD happens: the histamine surges, the GABA receptor glitch, the progesterone metabolite that either calms you down or completely wrecks you depending on your unique biology. If you haven't listened to that one yet, start there, because this episode builds directly on it. Now we get into the part everyone actually wants to know: what do you do about it? We talk about why popular fixes like DAO supplements and strict low histamine diets usually fall short, and what to focus on instead, starting with your gut, your liver, and your nervous system. Dr. Liz walks through her actual clinical protocols, including specific nutrients, herbs, and the EndoAccess formulas she uses with patients who have histamine overload, progesterone sensitivity, or both. We also get into the harder conversations: when a 5-alpha reductase inhibitor might help women who are pushing too much allopregnanolone, what's really going on hormonally for women hitting perimenopause with worsening PMDD, and yes, when birth control or even an SSRI might actually be the safest, most compassionate choice, even for someone who leans natural. Dr. Liz makes a case that will challenge how you think about "first, do no harm." This episode is about giving you an actual roadmap, not just information. Because once you understand your own biology, from part one, you can finally stop guessing and start treating the right thing. In This Episode, We Cover: Why DAO supplements and strict low histamine diets usually don't solve the problem long term The gut, liver, and nervous system focused approach Dr. Liz uses first with patients Key nutrients and antioxidants for calming histamine and neuroinflammation, including glutathione support, sulforaphane, green tea, pomegranate, curcumin, NAC, and glycine Why alcohol is one of the biggest hidden disruptors of histamine clearance and hormone balance Specific probiotic strains, including lactobacillus plantarum, and their surprising role in GABA receptor expression The EndoAccess formulas Dr. Liz uses clinically for histamine support and for progesterone sensitive PMDD, including early results from a small group of patients What 5-alpha reductase inhibition is, how it relates to allopregnanolone, and when it may help Why perimenopausal women can suddenly develop worse PMDD, and the surprising role of testosterone, insulin, and FSH The honest conversation about birth control, newer options, and when it may be the safest choice for severe PMDD Where SSRIs fit in, including luteal phase only dosing and what to support alongside them Why the nervous system piece is the part most women skip, and why it may be the most important one Who This Episode Is For This is for women who now understand why they're struggling, from part one, and want an actual plan. It's for anyone who has tried supplements or progesterone with no luck and felt like they were out of options. It's especially for women in perimenopause noticing their PMDD or PMS getting dramatically worse, and for anyone who has felt conflicted about whether birth control or an SSRI could ever be the "right" choice for them.     Sponsors Join the Midlife Women's Peptide Program today and get started for less than $200 a month! Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE Get 15% off Magnesium Breakthrough By BiOptimzers at bioptimizers.com/hormone with coupon code HORMONE.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

In this School of Doza episode, Nurse Doza reframes "I'm so tired" as a code with five different signals—and shows how to read yours. He breaks down the five types of energy the body actually runs on: dopamine for drive, cortisol for the morning wake-up, blood sugar and mitochondria for cellular fuel, glutathione to clear cellular clutter, and NAD for turning food into energy. Instead of masking fatigue with more caffeine, he explains how to spot the one you're missing and fuel it. FEATURED PARTNER Boost by MSW Nutrition is the "multivitamin you can feel"—the raw-materials approach to energy Nurse Doza describes in this episode. One stick delivers a big hit of methylated B12, electrolytes and minerals, plus antioxidants like glutathione and vitamin C, and it uses a slow-release caffeine technology for steady, usable energy instead of a spike-and-crash (a Caffeine Free option is available too). That's why Boost is his go-to for filling the nutritional gaps behind low energy.

Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims. Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.   Quick Coherence Technique — HeartMath https://help.heartmath.com/introduction/quick-coherence-technique/ The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al. https://pubmed.ncbi.nlm.nih.gov/36142272/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific https://www.quicksilverscientific.com/products/facial-beauty-serum Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri Vladimir Khavinson Publications — Professor Vladimir Khavinson https://khavinson.info/publications   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:57 GLP-1 Starting Doses 03:39 GLP-1 Anti Inflammation Aging 07:15 Motility Supplements Side Effects 09:02 Tirzepatide vs Semaglutide 11:46 Adrenal Fatigue Myth 13:23 Fatigue Bloodwork Checklist 16:16 TRT Hematocrit Sleep Apnea 19:01 Underrated Blood Tests 20:06 Womens HRT Basics 22:21 Testosterone for Women 25:19 Thyroid Treatment LDN NAD 29:31 Progesterone GABA Sleep 32:25 Progesterone for Men Debate 33:43 Testosterone Injection Frequency 36:05 TRT Dosing Frequency 36:45 Why TRT Stops Working 37:50 Creams vs Injections 39:08 Fertility and HCG 41:46 Peptides vs Pharma 44:17 HGH and Secretagogues 45:12 5-Amino-1-MQ Hype 48:15 Topical GHK-Cu Skincare 50:25 Injectable Copper Peptide Hair 52:26 BPC 157 and TB500 58:25 Thymosin Alpha 1 Immunity 01:01:13 Mitochondrial Peptides 01:03:20 Endo 205 and New Peptides 01:04:17 Kavinson and Epitalon 01:08:21 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

If you've been on social media lately, you've probably seen it: women swearing that a combo of Pepcid and Claritin, ordinary histamine blockers, gave them their life back during the worst days of their cycle. It sounds too simple to be real, and honestly, it kind of is. But the reason it's working for some women and doing absolutely nothing for others is the whole story, and it's a story almost nobody is explaining correctly. In this episode, I sit down with one of my all time favorite guests, Dr. Liz Bartman, to go deep into progesterone sensitivity, PMDD, premenstrual dysphoric disorder, and how it's different from garden variety PMS. If you've ever felt like a completely different person for two weeks out of every month, only to feel like yourself again the second your period starts, this episode is going to make you feel seen in a way most conversations about "hormones" never do. We get into what's actually driving PMDD for so many women: an altered GABA receptor that stops responding correctly to a calming metabolite of progesterone called allopregnanolone. We talk about why histamine surges at exactly the wrong time in your cycle, how estrogen and progesterone are pulling the strings behind the scenes, and why some women feel like magic when they take progesterone while others feel like they've been poisoned by it. This is the foundational science you need before you try any protocol, viral or otherwise. This is part one of a two part series. Part two gets into what to actually do about it, but you need this piece first, because throwing supplements or medications at PMDD without understanding your own biology is how so many women end up frustrated and back at square one. In This Episode, We Cover: The real difference between PMS and PMDD, and why PMDD is classified as a mental health condition, not just a hormone imbalance Why normal estrogen and progesterone levels don't rule out PMDD, and what's actually going on in the brain instead What allopregnanolone is, how it works on GABA receptors, and why some women's brains stop responding to it correctly The viral H1/H2 histamine blocker protocol: what it is, why it can bring real relief, and why it isn't a PMDD cure-all The surprising role histamine plays as a neurotransmitter, including its connection to your morning cortisol response Why PMDD symptoms show up specifically in the second half of your cycle, and how estrogen, progesterone, and mast cells are all involved Why roughly half of women with diagnosed PMDD don't tolerate progesterone well, and what that tells us about the root cause How your gut microbiome, specific probiotic strains, and your nervous system state all influence GABA receptor expression and histamine regulation Why declining egg quality and corpus luteum function can cause progesterone to drop too fast in the luteal phase Who This Episode Is For This is for any woman who has ever felt like her brain and body get hijacked in the days before her period, and who has been told it's "just PMS" or that she's overreacting. It's for women who have tried progesterone and either felt amazing or felt so much worse, and never got a real explanation why. It's also for anyone who has seen the histamine blocker trend online and wants to understand the actual mechanism before trying it themselves.     Sponsors Join the Midlife Women's Peptide Program today and get started for less than $200 a month! Head to cozyearth.com and use my code HORMONES for 20% off sitewide! And if you get a Post-Purchase Survey, make sure to let them know you heard about Cozy Earth right here! Try the power of copper peptides on your skin today and get 20% off your order with coupon code km20 here.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Send us Fan MailLithium is one of those molecules most people think they understand, until you zoom out. Yes, it's a time-tested medication for bipolar disorder. But at tiny, trace doses, lithium starts to look like something else entirely: a potential micronutrient with outsized influence on mood stability, inflammation, and brain ageing.We walk through why interest in low-dose lithium is rising in the brain health and longevity world, even as human clinical trials are still early. John and I talk about what lithium is chemically, why it's so bioavailable, how it crosses the blood-brain barrier, and why the kidneys matter more at prescription doses than at supplement-scale milligrams. Then we connect the dots on mechanisms people care about most for neuroprotection: GSK-3 inhibition, support for BDNF, a tilt toward calming inhibitory signalling (GABA), better balance in serotonin pathways, and less glutamate-driven mitochondrial stress.We also wrestle with the bigger public health angle: what happens when we treat chronic disease as “too much of everything” and ignore deficiency and nourishment. Soil mineral depletion, variable food mineral content, and strong population associations with lithium in drinking water (including mental health measures and Alzheimer's mortality) make this a conversation worth having, carefully and objectively.For slides and open-source references: www.thehealthedgepodcast.comIf this sparks questions for you, subscribe, share it with a friend, and leave a review so more people can find the show.

Estrogen dominance is the hidden imbalance behind why your PMS, weight gain, and mood swings all hit at the same time — and most doctors never test for it. Nurse Doza breaks down four clinical reasons your cycle goes sideways: inflammation, dysregulated estrogen, your gut microbiome (the estrobolome), and an inflamed liver. Learn how your gut and liver actually regulate estrogen, why birth control isn't the fix, and the daily habits that restore a healthier, calmer cycle. Featured Product: Boost by MSW Nutrition When your hormones go sideways before your period, energy is usually the first thing to crash — the afternoon wall, the brain fog, the "I could nap standing up" fatigue Nurse Doza describes in this episode. Boost is the multivitamin you can actually feel: 2,500 mcg of methylated B12, a full multivitamin plus B-complex, electrolytes, and plant-based antioxidants including S-acetyl-L-glutathione — with a built-in liver detox support blend to help your body do the clearing work we talked about today. Clean, slow-release energy from one stick in water. No sugar, no crash.

Deep sleep and REM sleep get lumped together as "good sleep," but they're almost opposite states — one is the quietest your brain gets all night, the other is nearly as active as being awake. In this episode we pull the two apart: how we stumbled onto each of them, what's happening chemically while they run, and why one of them quietly shrinks as we age while the other holds steadier. In this episode we will:Break down what's actually happening in slow-wave sleep versus REM — brainwaves, muscle tone, and why one is a "quiet body, quiet brain" state and the other is "quiet body, active brain"Trace the history back to 1953, when a University of Chicago graduate student stumbled onto REM sleep almost by accidentGet basic on the neurochemistry: the GABA-driven shutdown that produces deep sleep, and the acetylcholine surge that flips REM onBring in new data from SLEEP 2026 in Baltimore, including a 22-million-night wearable dataset showing how deep sleep changes across adulthood, and a mattress-temperature study that moved the needle on restful sleep by nearly 20 minutes a nightCover what actually protects deep sleep — and what quietly wrecks it, from alcohol to late caffeine to a bedroom that's too warmTo find out more about this week's podcast sponsor SideSleeperZ, please use the following link: https://sidesleeperz.com/Original intro music Vigilanteology by Abhinav Singh (copyright 2026) Original outro music Vigilanteology (reprise) by Abhinav Singh (copyright 2026)Produced by: Maeve WinterMusic by: Dr. Abhinav Singh (@sleep_vigilante), all rights reservedMoreTwitter: @drchriswinterIG: @drchriwinterThreads: @drchriswinterBluesky: @drchriswinterThe Sleep Solution and The Rested ChildThanks for listening and sleep well!

If you've ever been told you have anxiety or depression without anyone checking your hormones first... this episode is for you. In this episode of Boss Bitch Radio, I dive into a conversation that I believe every woman needs to hear. Too many women are walking out of doctor's offices with prescriptions for antidepressants without ever getting a full hormone panel. While medication absolutely has its place, I'm asking a different question: What if your hormones are part of the real story? We're talking about how estrogen, progesterone, and testosterone affect your mood, sleep, energy, motivation, brain fog, and anxiety - especially during perimenopause and menopause. I also share my own experience with hormone changes, why I believe so many women are being misdiagnosed, and the lifestyle habits that can help support your hormones before we even get into treatment options. This episode isn't about fear or blaming doctors. It's about becoming your own advocate, asking better questions, and making sure you're getting the full picture before accepting that feeling anxious, exhausted, or emotionally flat is "just part of getting older." #Hormones #Perimenopause #Menopause #MentalHealth   Key Takeaways: 01:41 The 3 Hormones That Control Your Mood 02:46 Why Estrogen Affects Your Happiness 03:58 Progesterone, Anxiety & Better Sleep 05:26 Low Testosterone = Low Motivation? 08:50 Why So Many Women Get Misdiagnosed 10:26 The Stats That Will Shock You 12:26 Why Blood Work Should Come First 13:39 Simple Habits That Actually Help 19:10 When Healthy Habits Aren't Enough 20:39 Getting Real Answers with Hormone Testing 22:39 What I Hope You Take Away From This Episode Links mentioned: Ready to feel like yourself again? Visit Ivologist and use code DIANE50 for 50% off! https://ivologist.com/   Sources & References Menopause & Depression Risk (SWAN Study): Research shows women are 2–4 times more likely to experience a major depressive episode during the menopause transition. https://pubmed.ncbi.nlm.nih.gov/21306662/ https://www.swanstudy.org/womens-health-info/depression-menopause/ Antidepressants vs. Hormone Therapy: Approximately 1 in 3 women in perimenopause are prescribed antidepressants or anti-anxiety medications for mood symptoms, though current guidelines recommend considering hormone replacement therapy (HRT) when appropriate. https://pharmaceutical-journal.com/article/letters/assessing-the-suitability-of-antidepressant-use-during-perimenopause CDC (2023): Women are more than twice as likely as men to take antidepressants (15.3% vs. 7.4%) https://www.cdc.gov/nchs/products/databriefs/db528.htm How Estrogen Affects Mood: Estrogen plays a key role in regulating neurotransmitters such as serotonin, dopamine, and GABA. Fluctuations in estradiol levels during perimenopause and menopause can significantly influence mood https://pmc.ncbi.nlm.nih.gov/articles/PMC7075107/ https://www.sciencedirect.com/science/article/pii/S0378512224001828 2025 Research on HRT: A recent study suggests that hormone replacement therapy - particularly when combined with testosterone - may reduce the need for antidepressants in menopausal women https://academic.oup.com/jsm/article/22/Supplement_1/qdaf068.081/8119509 Want more? Join the newsletter! Behind the scenes of the pivot, brand partnerships, real life in progress, and the things I'd only tell you in a DM: https://www.bossbitchradio.com/newsletter   Connect with Diane: Website: https://www.bossbitchradio.com/  Come find me on Instagram and reply to my Stories. I actually read everything and your opinion literally shapes the brand work I do:  https://www.instagram.com/thebossbitchdiane/  YouTube: https://www.youtube.com/@dianeflores_ifbb_pro  Are you a brand looking to work with me? I create content for brands I actually use and love. With 19 years of marketing and sales experience and an audience of women over 40 who are done being ignored by the brands that should be speaking to them. View my portfolio and let's talk: https://buffbunny.my.canva.site/diane-flores-ugc-portfolio  Freebies: Fit Girl Gift Guide: https://www.bossbitchradio.com/fit-girl-gift-guide  My Favorite Supplements: https://www.bossbitchradio.com/myfavoritesupplements  Protein Snack List: https://www.bossbitchradio.com/protein-snack-guide  Lower Body Blueprint: https://www.bossbitchradio.com/lower-body-blueprint  Full Body Training Program: https://www.bossbitchradio.com/full-body-gym-program 

A new Tennessee law is about to change access to CBD, THC/THCA, and kratom - and Dr. Barrett Deubert breaks down what's actually happening, why it's happening, and what it means for anyone using these products. Drawing on his own firsthand experience with all four substances, he walks through the real benefits (sleep, inflammation, nerve pain, focus) and real risks (addiction, anxiety, dependency) of CBD, THC, kratom, and nicotine - plus healthier alternatives like L-theanine, GABA, glycine, ashwagandha, and adaptogenic mushrooms for people looking to dial things back.. . . Watch the episode on YouTube here! Click here to view the episode transcript! Podcast Team Dr. Barrett Deubert - Host Grant Crenshaw - Editor (00:00) - Intro (00:37) - What's Being Regulated (02:27) - CBD (03:16) - THC/THCA (03:50) - Kratom & Nicotine (05:49) - Tennessee's New Law (07:13) - The Bigger Picture (09:33) - Healthy Alternatives (12:25) - Resetting Addiction & Closing DISCLAIMERThis content is strictly the opinion of Dr. Barrett Deubert and is for informational and educational purposes only. It is not intended to provide medical advice or to replace medical advice or treatment from a physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding health questions and concerns. Neither Dr. Deubert nor the Real Health Co. takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All audience members, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

If you’ve ever wondered whether alcohol permanently damaged your body—or you’ve quit drinking and found yourself asking, Why am I so anxious? Why can’t I sleep? Why do I still have brain fog?—this episode is for you. Today I’m walking you through what actually happens inside your body after you stop drinking. Not the social media myths. Not the gimmicks. The real biology. You’ll learn how alcohol changes your brain chemistry, why early sobriety can feel so intense, and what your body is doing behind the scenes to restore balance. We talk about the science behind sleep disruption, why your liver is one of the most remarkable organs in your body, how alcohol affects your gut, heart, immune system, and hormones, and why so many people begin feeling physically better long before they feel emotionally healed. One of the biggest messages I want you to take away is this: feeling worse after you quit drinking doesn’t mean alcohol was helping you. It means your body is recalibrating after years of adapting to alcohol. But we also have an important conversation about what sobriety doesn’t magically fix. Trauma, stress, anxiety, menopause, low testosterone, nervous system dysregulation, and emotional healing don’t disappear simply because you stopped drinking. Recovery is bigger than removing alcohol—it’s learning how to build a life you don’t want to escape from. In this episode, you’ll learn: 01:25 Your brain: GABA, glutamate & early sobriety 05:56 Alcohol and sleep: why you wake up at 3 AM 13:38 Your liver’s incredible ability to heal 19:07 Gut health, nutrient absorption & inflammation 24:22 Your heart, immune system & hormones after alcohol 36:26 Physical healing vs. emotional recovery If you’ve been wondering whether your body can recover after years of drinking, I hope this episode gives you something so many people desperately need in early sobriety: hope. Your body isn’t working against you. It’s been fighting for you all along.   Links mentioned in this episode:  Book A Call with Angela: addictionunlimited.com/call Join Sober Society: addictionunlimited.com/society Related Episode: Worried About Your Health in Sobriety? Here's How Your Body Heals After Drinking Instagram:  @addictionunlimited Facebook Group: https://www.facebook.com/groups/addictionunlimited     Prefer to read instead of listen? Here's the full transcript of this episode. Angela (00:11.96) Hello, my friend. Welcome back to Addiction Unlimited Podcast. I’m your coach, Angela Pugh. If you’ve ever wondered whether alcohol permanently damaged your body, or you’ve quit drinking and found yourself asking, like, is this normal? Why am I so tired? Why am I anxious? Why can’t I sleep? Why do I still have brain fog after a month? Then this episode is for you. Because here’s what I want you to know right from the beginning. Your body wants to heal. In fact, healing begins within hours of your last drink. And while every person’s recovery looks a little different depending on how long they drank, how much they drank, age, genetics, nutrition, overall health, the human body is remarkably resilient. Today we’re going to walk through what alcohol actually does to different systems in your body, what happens when you remove it, what kind of timeline you can realistically expect. And why some parts of recovery happen on a calendar while other parts happen because of the work you choose to do. Angela (01:24.884) Here’s the thing about alcohol that almost nobody explains right. It’s not a substance your brain tolerates, it’s a substance your brain adapts to. Every single time you drink, your brain has to do damage control. And alcohol is a depressant. And before we go any further, I want to clear up one of the biggest misconceptions about that concept. When we say alcohol is a depressant, We don’t mean it makes you depressed or sad. We mean it depresses or slows down the activity of your central nervous system. Think of your central nervous system as the command center for everything your body does. It’s your brain and spinal cord communicating with every other system in your body. It controls your thoughts, your reaction time, your breathing and heart rate. Your coordination, your judgment, memory, emotions, everything. Alcohol comes in and starts turning the volume down on that entire system. Your thoughts and reflexes slow down, your reaction time slows down, your coordination gets worse, speech changes, your judgment becomes impaired. That’s what a depressant does. It slows the activity of your nervous system. But here’s where it gets really interesting. Your brain is obsessed with one thing, keeping you alive. And more specifically, it wants balance. Scientists call this homeostasis. Your brain wants everything operating within a pretty narrow range. So when alcohol keeps slamming on the brakes, Angela (03:13.194) Your brain wants everything operating within a pretty narrow range. So when alcohol keeps slamming on the brakes, your brain doesn’t just sit there and accept it, right? It adapts. It starts pressing the gas pedal to compensate. It ramps up excitatory chemicals, mainly glutamate. And over time it becomes less responsive to the calming effects of GABA because alcohol. Has been providing that calming effect artificially. Angela (03:47.384) Think of GABA as your brain’s brake pedal and glutamate as the gas pedal. As alcohol continues slowing everything down, your brain pushes harder on the gas just to keep you functioning normally. That’s why many people who drink heavily don’t necessarily look intoxicated because they’ve developed tolerance because their brain has adapted. But then one day you stop drinking. Suddenly the artificial breaks disappear. But your brain is still pressing on the gas. That’s why early sobriety can feel so physically and emotionally intense. Anxiety, restlessness, racing thoughts, irritabilities, shaky hands, trouble sleeping, feeling like your skin is crawling. Those aren’t signs something is wrong. They’re signs that your brain is trying to find its balance again. And every day you stay alcohol-free. Your brain begins adjusting in the opposite direction. It gradually turns the glutamate back down, restores its normal response to GABA, and it starts regulating itself without alcohol. That process doesn’t happen overnight, right? But it does happen. One of the biggest mistakes people make is believing that because they feel worse after they quit drinking, like alcohol must have been helping them. But that’s not what’s happening. You’re experiencing life without alcohol. You’re not experiencing life without alcohol. You’re experiencing a brain that’s recalibrating after alcohol. Those are two very different things. Angela (05:56.344) So we talked about the brain. Let’s talk about sleep. One of the biggest lies alcohol tells us is that it helps us sleep. I cannot tell you how many people say to me, Angela, I have to have a few drinks or I’ll never fall asleep. And I get it, I was exactly the same way. It certainly feels that way. Alcohol can absolutely make you fall asleep faster, but falling asleep and getting quality sleep are two completely different things. Think about it this way: if someone put you under anesthesia, Would you call that a great night’s sleep? Of course not. You were unconscious, but your brain wasn’t cycling through the normal stages of restorative sleep that your body needs. Alcohol works in a similar way. It sedates you, but it disrupts the quality of your sleep. One of the biggest problems is that alcohol suppresses REM sleep. REM stands for rapid eye movement, and it’s the stage of sleep. That is incredibly important for learning, memory, emotional processing, and just overall brain health. It’s also the stage where most dreaming happens. So even if you’ve slept for eight hours after drinking, your brain may have missed out on some of the most restorative parts of sleep. Alcohol also causes your sleep to become fragmented. Like you may fall asleep quickly, but as your body metabolizes the alcohol during the night, your brain becomes more active. It gets agitated. That’s why so many people wake up at two or three in the morning with their mind racing, heart pounding, feeling Wide awake, even though you’re exhausted. Your heart rate stays higher, your body temperature is less regulated, your breathing can become less stable, and your nervous system is working much harder than it should while you’re supposed to be recovering. The good news is this starts to improve surprisingly quickly. During the first few days after quitting drinking, sleep sometimes can get worse before it gets better. That’s completely normal. Angela (08:03.212) Because your brain is learning how to fall asleep without alcohol, and that recalibration takes time. But over the next few weeks, your sleep architecture, right? The normal pattern of moving through different stages of sleep, all of that starts to recover. Many people begin noticing they’re sleeping more deeply, they’re waking up fewer times during the night and actually feeling rested in the morning. And that’s a huge difference. Because when you were drinking, you may have been unconscious for eight hours, but now you’re actually sleeping. And I also want to be really transparent about something because I think we do people a great disservice when we oversimplify recovery. Better sleep is one of the most common benefits of quitting drinking, but it isn’t a guaranteed, but it isn’t guaranteed on some magical timeline. Right. And I know this firsthand because I’ve never been a great a great sleeper. Not when I was drinking, and honestly, not long before I ever took my first drink. I’ve struggled with sleep since I was a young teenager. As I got sober, I started real recovery and healing, and I learned that alcohol wasn’t the only problem I had with sleep. I had a lot of problems with my nervous system. Years of chronic stress, trauma, and living in survival mode. Like all of that just taught my body it wasn’t safe to fully relax. And I know I’m not alone in that. Many people discover that alcohol wasn’t the root cause of their sleep struggles. It was just the way they were trying to cope with a nervous system that had been dysregulated for years. That was certainly my story. But once the alcohol was gone, I could finally see the other factors that were affecting my sleep. That’s why I want you to be careful about comparing your recovery to someone else’s timeline. There are so many variables. There are so many variables that affect sleep, right? Your history, stress levels, trauma, anxiety, depression, hormones, perimenopause and menopause, cortisol, blood sugar, caffeine, medications, sleep apnea. Angela (10:13.036) Like there are dozens of things that influence how well you sleep. But here’s what I can tell you without hesitation. The quality of my sleep improved dramatically. There’s a huge difference between spending eight hours unconscious because of alcohol and spending eight hours moving through the natural stages of restorative sleep that your brain and body are designed to have. Even if I still have a rough night here and there, I function better as a sober person, getting sober sleep than I ever did as a person who drank myself unconscious. My brain works better, my body feels better, I have more energy, my mood is more stable, my memory is sharper. I’m actually recovering while I sleep instead of asking my body to recover from what I drank. And that’s really the theme of this entire episode. Sobriety doesn’t remove every challenge from your life. It removes one of the biggest obstacles standing between your body and its ability to do what it was designed to do, and that’s heal. And once you’re finally getting real restorative sleep again, something else starts happening. Your body can begin repairing itself more efficiently. And one of the hardest working organs in that process is your liver. So let’s talk about what happens there. Angela (11:44.61) You know, one thing I always try to be honest about is that sobriety didn’t magically make me a perfect sleeper. I’ve struggled with sleep since I was a teenager. So anything that helps create a calmer, more comfortable sleep environment, I am all about it. I’ve been sleeping on cozy earth sheets for a while now, and they really are as good as everyone says. They didn’t make it to Oprah’s favorite things list for no reason. Okay, they’re incredibly soft. And honestly, they make getting into bed at the end of the day feel like its own little luxury. And since we’re talking about recovery, I think this fits perfectly. Recovery isn’t just about removing alcohol. It’s about taking care of yourself in ways that actually support healing. And creating a bedroom that helps you relax and get quality rest is one of those things that’s worth investing in. I also love that Cozy Earth stands behind what they make. Their sheets come with a hundred-night sleep trial, their clothing has a lifetime warranty. And if something isn’t right, returns are hassle-free. That tells me they’re confident in their products. And I appreciate companies that stand behind what they sell. Summers should feel easy for everyone in the house. Cozy Earth’s bamboo sheet set, the men’s everywhere pant, the women’s joggers. They’re all amazing, comfortable, and designed to keep you relaxed all summer long. Head to cozyearth.com and use my code ANGLE for an exclusive 20% off. That’s code ANGLE for an exclusive 20% off. And if you see a post-purchase survey, mention that you heard about Cozy Earth right here on Addiction Unlimited. Angela (13:38.166) Okay, back to the liver. I have to tell you, I’m absolutely fascinated by the liver. If you’ve listened to this podcast for any length of time, you already know I’m a total brain nerd, right? I can talk about the brain for hours. But the liver, it is a very close second. It’s one of the smartest, hardest working, most dynamic organs in your body, and it doesn’t get nearly enough credit. The liver performs more than five. Hundred different functions every single day without you having to think about a single one of them. Like I say that and it makes me feel lazy. You know? It filters your blood, processes nutrients, stores vitamins, helps regulate blood sugar, produces bile so you can digest food, it makes proteins your body needs, it metabolizes medications, it supports your immune system. It just quietly goes about its business keeping you alive. Every second of every day. Then alcohol shows up. You know, the liver’s number one priority becomes breaking down that alcohol because, from your body’s perspective, alcohol is a toxin. And here’s the catch. While your liver is busy processing alcohol, many of its other jobs get pushed to the back burner. It’s like pulling your best employee away from everything they should be doing because they’re dealing with one emergency after another. If drinking becomes frequent or heavy, that emergency never really ends. Fat begins to accumulate in the liver. That’s what’s known as fatty liver disease. And it’s often the first stage of alcohol-related liver damage. the the important thing to know is that fatty liver doesn’t usually hurt, right? Most people don’t feel it happening. There may be no symptoms at all. That’s why a lot of people have no idea it’s developing. But if drinking can Continues, that fat can lead to inflammation. And over time, repeated inflammation can lead to scarring called fibrosis. If enough scar tissue builds up, it can eventually become cirrhosis. And that’s where that healthy liver tissue is permanently replaced by scar tissue. Now, I don’t tell you that to scare you. I tell you because understanding what’s happening inside your body helps make you. Angela (16:06.134) I tell you because understanding what’s happening inside your body helps you make better decisions. And here’s the hopeful part: the liver is one of the few organs in the body with an incredible ability to regenerate. In many people, healing begins within days of stopping drinking. Fat accumulation can begin to decrease within just a few weeks. And over the following months, many people with fatty liver disease can see significant improvement. It can be completely reversed if permanent damage hasn’t already happened, right? Inflammation goes down, liver function improves, your body becomes more efficient at processing nutrients and eliminating waste. Now, if someone has advanced cirrhosis, that’s a different conversation. Scar tissue that’s already formed generally can’t be reversed. But even then, stopping alcohol can slow or stop further damage. And obviously it’s gonna dramatically improve quality of life. So wherever you are on that spectrum, removing alcohol is one of the best gifts you can give your liver. Angela (17:21.354) And did you know that the liver actually has the capacity to regrow healthy tissue? Like surgeons can take a portion of a healthy liver for a living donation, and both the donor’s liver and the recipient’s transplanted portion will grow to meet the body and that body’s needs over time. I mean, think about that for a minute. It it’s amazing. It’s such an amazing organ. But so many people come into recovery believing they’ve ruined their bodies forever. And while none of us can erase the past, you have to understand the human body is amazingly resilient. If we give it the opportunity, it starts moving toward healing almost immediately. Like your liver is not just sitting there hoping for the best. You know, it’s constantly adapting, constantly repairing, constantly trying to keep keep up with whatever we throw at it. The problem is that every time alcohol shows up, your liver has to stop what it’s doing and deal with the emergency in front of it. And if alcohol keeps showing up day after day, your liver never gets the chance to fully catch up on all of its other incredibly important jobs. So the greatest gift you can give it isn’t some expensive detox tea or a cleanse you found on Instagram. Your liver already knows how to detox your body. That’s literally its job. It doesn’t need help doing its job. It just needs you to remove the thing that’s been monopolizing all of its attention. Every day you don’t drink, it can just get back to work trying to heal. And I love that because there’s a lesson in that for all of us, right? Our bodies. Angela (19:06.998) Are often far more willing to forgive us than we are willing to forgive ourselves. Your brain wants balance, your liver wants to heal. Your body is constantly trying to move you toward health. Our job isn’t to force the healing. Our job is to stop getting in its way. Okay, let’s keep following the path that alcohol naturally takes through the body, because alcohol doesn’t just affect your brain and your liver. It affects your digestive system from the very first sip. Your mouth, your esophagus, your stomach, your intestines, every step of the journey. Alcohol is incredibly irritating to the lining of your digestive tract. And over time it creates inflammation and it makes that lining more permeable. You may have heard the term leaky gut. And that phrase gets used a lot online. The medical concept behind it is what’s called increased intestinal permeability. And here’s what that means in plain English: the lining of your intestines is designed to be selective. Think of it like a really smart security guard or a coffee filter. It’s supposed to let the good stuff through things like vitamins, minerals, amino acids, and other nutrients your body needs. While keeping larger particles, toxins, and bacteria out. Alcohol can damage that protective barrier over time. Instead of being as selective as it’s supposed to be, it becomes a little more leaky. Things that normally wouldn’t pass through can slip into the bloodstream. And that triggers inflammation and forces your immune system to work harder than it should. At the very same time, your body may become less efficient at absorbing some of the nutrients it desperately needs. The protective barrier in your intestines just doesn’t work quite as well as it should. And that matters because your digestive system isn’t just responsible for digesting food, it’s responsible for absorbing nutrients. And if your body can’t absorb nutrients efficiently, it doesn’t matter how healthy you’re eating. Angela (21:25.206) You’re not getting everything your brain and body actually need. Angela (21:35.286) And alcohol interferes with the absorption of a lot of nutrients, especially B vitamins, folate, magnesium, zinc. These nutrients are involved in everything from energy production to nerve function to brain health. So when people say they feel exhausted all the time while they’re drinking, alcohol itself is part of the story. But nutritional deficient, but nutritional deficiencies can be part of that story too. Then there’s the microbiome. Your gut is home to trillions of bacteria. And I know that sounds a little gross, but you actually want them there. Those bacteria help digest food, they provide certain vitamins, they support your immune system, and they communicate with your brain. Researchers call it the gut brain axis because your gut and your brain are in constant communication. So when alcohol repeatedly disrupts that environment, it can throw the whole system out of balance. And that contributes to bloating, digestive issues, inflammation, and even mood changes. The good news is your digestive system is another one of those parts of the body that starts responding pretty quickly once alcohol is removed. Many people notice less bloating in the first week, right? And Digestion becomes more regular over the following weeks. Acid reflux may improve, stomach irritation calms down, your body becomes better at absorbing nutrients again. Angela (23:18.862) And when your body starts absorbing nutrients more efficiently, you’re giving your brain better raw materials to work with. That’s another reason people will often notice improvements in energy and concentration and mood over time. It’s not one magical thing, it’s dozens of systems all getting a chance to do their jobs again. And I do want to make one thing clear because I don’t think because I don’t want anyone listening to think sobriety automatically fixes every digestive issue you’ll ever have, right? If you have food sensitivities, IBS, celiac, gallbladder problems, another medical condition, those don’t magically disappear because you quit drinking. Again, life is still going to be life, but removing alcohol eliminates one major source of irritation. It gives your digestive system a chance to calm down and work the way it was designed to work. Angela (24:21.804) And I love that idea because it keeps coming back to the same theme. Your body isn’t sitting around waiting to fail you, it’s constantly trying to heal you. Sometimes it just needs you to stop interrupting the process. So let’s talk about your heart. Your heart has one job, right? Keep blood moving. Every minute of every day, it’s delivering oxygen and nutrients to every cell in your body and carrying away waste products. And just like your liver, it never takes a day off. Alcohol asks a lot of your heart. Even a single night of heavy drinking raises your heart rate and your blood pressure. That’s one of the reasons so many people wake up after drinking feeling like their heart’s pounding out of their chest. It isn’t just anxiety. Your cardiovascular system is working harder than it should. And when drinking becomes frequent, that extra workload starts adding up. Alcohol can contribute to high blood pressure, irregular heart rhythms, inflammation, and over many years, it can weaken the heart muscle itself. It also increases your risk for heart attack, stroke, especially with long-term heavy drinking. The encouraging news is that your heart responds surprisingly well when alcohol is removed. For a lot of people, heart rate begins settling down within days. Blood pressure often starts improving in a matter of weeks, although that depends on a lot of factors too: genetics, weight, medications, diet exercise, other health conditions, blah, blah, blah. Again, I don’t want to oversimplify it. Sobriety isn’t a cure for every heart condition, but removing alcohol takes a tremendous amount of unnecessary stress off your cardiovascular system. Your heart isn’t Constantly trying to compensate anymore. It gets to just do the job it was designed to do instead of cleaning up after alcohol all the time. Angela (26:29.242) And when your heart is pumping efficiently, then your circulation improves, and oxygen and nutrients are getting where they need to go. And every other system benefits from that. Your muscles recover better, your brain gets better blood flow, your energy improves, even your skin looks healthier because of improved circulation and reduced inflammation, right? Everything in your body is connected. That’s something I hope you’re starting to hear throughout this episode. We tend to think about alcohols affecting one organ at a time or whatever, but your body doesn’t work that way. Your brain talks to your gut, your tu your gut talks to your immune system, your liver supports metabolism, your heart delivers oxygen and nutrients everywhere. They’re all part of the same team. And when alcohol is out of the picture, it’s not just one player that gets better. The whole team starts working together again. And then there’s your immune system, right? I think this is another one of those systems that doesn’t get enough credit. Most of us only think about our immune system when we catch a cold or the flu. But your immune system is working every single day. It’s identifying viruses and bacteria, it’s repairing damaged tissues, cleaning up injured cells, helping wound. Helping wounds heal, monitoring for abnormal cells. It’s constantly scanning, communicating, and protecting you. And alcohol throws a wrench into that entire process, right? One of the biggest things alcohol does is increase inflammation throughout your whole body. Now, inflammation isn’t automatically a bad thing, right? If you cut your finger, inflammation is what helps it heal. If you catch a virus, inflammation is part of your body’s defense system. Angela (28:25.282) The problem is when inflammation never really gets the chance to turn off. That’s what chronic inflammation is. It’s like having your home’s smoke alarm going off all day, every day. Eventually, the whole system becomes stressed. Alcohol can keep your immune system in that constant state of activation. It’s responding to the alcohol itself. It’s responding to damage in the liver. It’s responding to changes in the gut. It’s responding to disrupted sleep. Everything we’ve talked about so far is connected. And over time, that chronic inflammation can contribute to fatigue, slower healing, increased risk of getting sick, and a higher risk for a lot of chronic diseases. Alcohol doesn’t just overactivate parts of your immune system. It can also weaken your ability to fight infections effectively, right? So if you’re in this strange situation where your immune system is working overtime in some ways while becoming less effective in others, it’s busy, but not necessarily efficient. When you stop drinking, that constant alarm finally starts quieting down. Inflammation begins decreasing, your immune system isn’t spending all of its energy responding to alcohol anymore. And it can start focusing on what it’s actually designed to do. And a lot of people notice they don’t get sick anymore. That was huge for me. I had like clockwork a few times a year. I would get super sick and be in bed for, you know, seven, eight days. And I’ve been sober 20 years. I hardly ever get sick. I don’t even get sick when my whole family is sick. Лайк ітскрази the difference it makes. Angela (30:16.588) But even when you do get sick, you recover more quickly too, right? Cuts and bruises heal faster. You just feel better. And while you can’t see inflammation the way you can see a cut on your hand, you definitely notice its absence, right? Like you wake up feeling less puffy, your face looks, your face looks less swollen, your joints don’t ache quite as much. Like your body feels lighter. Again, it isn’t magic, it’s biology. Your body’s been trying to restore balance all along. Removing alcohol just gives it one less battle to fight every single day. I think that’s one of the most hopeful things about recovery. Your body isn’t waiting for permission to heal. It’s been trying to heal from the very beginning. And sometimes the greatest act of self-care isn’t adding another supplement or buying another wellness product. Sometimes it’s simply stopping the thing that’s keeping your body stuck in survival mode. Angela (31:20.832) Okay, and then there are hormones, fucking hormones, ruining lives all day, every day. Okay, that might be a little dramatic, but only a little. When most people hear the word hormones, they immediately think about women: estrogen, PMS, perimenopause, menopause. And yes, we’re definitely going to talk about that. But hormones aren’t just a women’s issue. Every single one of us is running on hormones. They are your body’s chemical. Messengers. Okay, think of them like tiny text messages traveling throughout your body, telling different organs and systems what to do and when to do it. They help regulate your mood, your stress response, appetite, metabolism, sleep energy, sex drive, reproductive health, blood sugar, muscle mass, your body temperature. They influence almost everything we’ve talked about in this episode. And alcohol has its hands in all of it. So let’s start with cortisol. That’s your body’s primary stress hormone. Remember back in the beginning of the episode when we talked about alcohol slowing your nervous system down and your brain trying to compensate? Well, alcohol also disrupts your stress response. It can temporarily make you feel relaxed while you’re drinking, but as it wears off, cortisol often rises. That’s one of the reasons so many people wake up at two or three in the morning feeling. Anxious and restless and sweaty or like their heart is racing. It’s not just anxiety. Your stress hormones are literally shifting while you’re sleeping. And then there’s blood sugar. Alcohol can cause blood sugar to swing up and down, especially if you’re drinking on an empty stomach or you’re drinking sugary drinks. Those swings don’t just affect your energy, they affect your mood, your cravings, your concentration, even your ability to sleep well. And then there are sex hormones. Ladies, if you’ve ever been in perimenopause or menopause, you probably don’t need me to tell you that hormones can make life interesting, let’s say. Hot flashes, night sweats, mood swings, brain fogs, sleep disruption. I mean, sound familiar? Alcohol makes every one of those symptoms worse. Angela (33:44.852) It can intensify hot flashes, fragments your sleep even more, increases anxiety, it adds another layer of inflammation to a body that’s already going through enormous hormonal changes. So if you’re wondering why that nightly glass of wine doesn’t seem to be helping anymore, or why you suddenly feel worse instead of better, that may be part of the reason. But I also want to say something to the men listening: alcohol affects your hormones too. Heavy drinking can lower testosterone levels over time. And that affects energy, mood, muscle mass, strength, recovery after exercise, sex drive, even fertility. So if you’ve been feeling tired all the time or struggling to build muscle despite working out, or you’re noticing a lower sex drive, or you just feel like you don’t have the same drive and motivation you used to have, alcohol may be playing a much bigger role than you think. Again, it’s about understanding what’s happening inside your body. The encouraging thing. Angela (35:05.214) And many of these hormonal disruptions begin improving once alcohol is removed, right? Cortisol becomes more regulated, blood sugar becomes more stable, sleep improves, which supports healthier hormone production, inflammation decreases, your body starts communicating with itself more effectively again. And again, I don’t want to oversimplify this because if you’re in menopause, alcohol isn’t the only reason you’re having hot flashes. If you’re a man with clinically low testosterone, Quitting drinking isn’t guaranteed to bring your levels back to normal. Hormones are complicated. Age matters, genetics matter, medical conditions matter, stress matters. Just like we talked about with sleep, life is still going to be life. But removing alcohol gives your endocrine system one less obstacle to overcome. It gives your body the opportunity to find its natural rhythm again instead of constantly reacting to a substance that throws the whole orchestra off tempo. And that’s really what hormones are all about: communication, coordination, and balance. When alcohol leaves the picture, your body finally gets a chance to start having the conversations it was designed to have. Angela (36:25.866) As we wrap up this episode, I hope there’s one thing you take away from everything we’ve talked about today. Your body is incredibly intelligent. It is constantly working to protect you, adapt to whatever you give it, and move you toward healing. Your brain adapts, your sleep begins to recover, your liver regenerates, your gut repairs, your heart gets a break, inflammation starts to come down. Your hormones begin finding their rhythm again. None of that happens because your body is punishing you, right? It happens because your body has been fighting for you all along. Alcohol didn’t stop your body from wanting to heal. It just kept interrupting the process. And the beautiful thing is the moment you remove alcohol, your body gets back to doing what it’s always wanted to do heal. Now, I also want to make one really important distinction before we finish. Everything we talked about today is biology. Your body does this work automatically, but your emotional healing is different. Learning how to regulate your emotions without alcohol, building confidence, healing your relationships, setting boundaries, managing stress, working through trauma, learning who you are without alcohol, creating a life you don’t want to escape from. Those things don’t happen on a timeline. There isn’t a study that says 47 days in, your confidence comes back, or after six months, you’ll finally forgive yourself. Right. That part of recovery depends on something completely different. It depends on the work you’re willing to do. And honestly, I think this is a part that people miss. They quit drinking and start feeling physically better. And then they hit this point where they think, okay, now what? I’m sober, but I still feel stuck. I don’t know what I’m supposed to be working on. I don’t feel confident. My sobriety doesn’t feel solid. And if that’s where you are, I want you to know you’re not doing anything wrong. You’ve just reached the next stage of recovery. Your body’s been healing. Now it’s time to help the rest of you heal. Angela (38:41.068) And that’s exactly the work I love, right? It’s the work I’ve been doing with clients for years because quitting drinking isn’t the finish line, it’s the foundation. Once alcohol is out of the way, we get to build a life that actually feels good to live. A life where you have the tools to handle stress without reaching for a drink. A life where you trust yourself again, a life where sobriety doesn’t feel fragile. It feels like freedom. So if you’ve been sober for a while and you’re wondering what comes next, or your recovery feels a little uncertain and you want guidance, I would love to help. You can book a call to talk to me about working together and what that looks like. You can do that at addictionunlimited.com forward slash call. Angela (39:34.742) And if you’re still in those early days of sobriety, be patient with yourself. Healing is happening even when you can’t see it. Your body is doing what it was designed to do. Give it time, give it support, and most importantly, understand you are healing. And I’d love to talk to you if you’re ready to get to work and actually enjoy your sobriety. Addictionunlimited.com forward slash call. That link is always in the show notes. Addictionunlimited.com forward slash call. I love you guys. I hope you’re having a fantastic day and I will see you next week.

Today, I'm delighted to share a compilation of adrenal-centric discussions with experts Drs. Sonya Jensen, Carrie Jones, Scott Sherr, and Will Bulsiewicz, and geneticist Dr. Yael Joffe, Nurse Practitioner Heather Quaile, and Physician's Assistant McCall McPherson. In this masterclass, we explore the effects of generational silence and how the thrifty genotype impacts the likelihood of poor metabolic health outcomes over time. We define the GABAergic system and the effects of decreased progesterone in perimenopause, and examine how our immune and nervous systems are impacted in midlife. We discuss the impact of GABA cofactors, the connection between adrenal and thyroid health, how stress affects ovarian aging, and the impact of genetics on our lifestyle choices and responses. We also unpack shift work and circadian rhythm disruption, and their influence on the gut microbiome. Join us for today's action - and information-packed, adrenal-centric podcast. I know you will enjoy listening to it as much as I enjoyed putting it all together. IN THIS EPISODE, YOU WILL LEARN: The impact of generational trauma on stress resilience and metabolic health across generations How famine exposure, family history, and cultural background could contribute to our metabolic and hormonal health How estrogen metabolism pathways can influence hormone balance and long-term health The importance of B vitamins, magnesium, amino acids, protein, and overall nutritional status for healthy liver function and detoxification How ongoing fight-or-flight activation can impair energy production and contribute to a cycle of worsening stress and fatigue How hormones, sleep, toxins, infections, and insulin resistance can influence mitochondrial performance The importance of optimizing thyroid and adrenal dysfunction together  How chronic stress and adverse childhood experiences can influence ovarian aging  How gut barrier dysfunction can contribute to chronic low-grade inflammation How genetics and epigenetics can affect our appetite, hormone metabolism, mood, and treatment responses Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Sonya Jensen On her book website: Heal Your Hormones, Reclaim Yourself Instagram Connect with Dr. Carrie Jones On Instagram Estrogen Detox Made Easy Hello Hormones with Dr. Carrie Jones - Podcast Connect with Dr. Scott Sherr On his ⁠website⁠ Troscriptions ⁠Health Optimization Medicine   One Base Health⁠⁠ Connect with McCall McPherson On Modern Thyroid Clinic Instagram and TikTok Modern Thyroid and Wellness Podcast Thyroid Lab Guide Connect with Heather Quaile On her website  Instagram Connect with Dr. Will Bulsiewicz On his website Connect with Yael Joffe On 3X4 Genetics Instagram Facebook Podcast Links: Ep. 559 Heal Your Hormones, Reclaim Yourself: Women's Health in Midlife with Dr. Sonya Jensen | Perimenopause, Menopause & Hormones Ep. 567 “Timing Is Everything” – The Best Way to Test Hormones, Cortisol & Thyroid for Real Answers with Dr. Carrie Jones BONUS: "The Sympathetic Spiral of Doom!” – The Fastest Way To Reset Your Nervous System & End Burnout with Dr. Scott Sherr Ep. 478 Thyroid Truths: Labs, Adrenals & Appetite Explained with McCall McPherson Ep. 498 Chronic Stress Is Aging Your Ovaries – The Shocking Link Between Trauma, Hormones & Menopause with Heather Quaile Ep. 537 The #1 Longevity Nutrient You're Missing – How Fiber Supercharges Your Gut, Immunity & Sleep with Dr. Will Bulsiewicz Ep. 558 Your DNA Isn't Your Destiny – The Most Actionable Way to Use Genetics for Weight Loss with Dr. Yael Joffe

Welcome to this week's Midlife Minute. In this episode, we're focusing on progesterone, exploring the differences between progesterone and progestins, how progesterone is used in clinical practice, and how individual responses can vary significantly. IN THIS EPISODE, YOU WILL LEARN: Why bioidentical progesterone and synthetic progestins are not interchangeable How early synthetic progestin studies continue to shape how progesterone is viewed How different routes of progesterone administration produce different effects  Why do some women experience stronger neurological or physical effects than others on the same progesterone dose How cyclical versus continuous use can affect how progesterone is used in the body  Why some women experience sleep or mood changes on oral progesterone The importance of personalized decision-making Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Resources:  The pharmacodynamics and safety of progesterone doi:10.1016/j.bpobgyn.2020.06.002 Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone doi:10.1016/0378-5122(93)90064-O Pharmacokinetics of progesterone and its metabolites allopregnanolone and pregnanolone after oral administration of low-dose progesterone doi:10.1016/j.maturitas.2005.11.005 Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women doi:10.1016/j.psyneuen.2019.104465 Behavior of Male Gamete Fusogen GCS1/HAP2 and the Regulation in Arabidopsis Double Fertilization doi:10.3390/biom13020208 Tolerance to allopregnanolone with focus on the GABA receptor doi:10.1111/j.1476-5381.2010.01059.x Effects of exercise training on the cardiovascular system: pharmacological approaches doi:10.1016/j.pharmthera.2007.03.010 Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABA modulators doi:10.1016/j.psyneuen.2009.02.003 Paradoxical effects of GABA modulators may explain sex steroid induced negative mood symptoms in some persons doi:10.1016/j.neuroscience.2011.03.061 Progesterone selectively increases amygdala reactivity in women doi:10.1038/sj.mp.4002030 Progesterone and allopregnanolone neuroprotective effects in the central nervous system doi:10.1016/S0006-8993(02)02366-5 Allopregnanolone and mood disorders doi:10.1016/j.pneurobio.2013.07.005 GABA receptor plasticity and neurosteroid cell withdrawal during the estrous cycle doi:10.1523/JNEUROSCI.2800-09.2009 Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study doi:10.1007/s10549-007-9523-x Management of Menopausal Symptoms: A Review doi:10.1001/jama.2022.24140 Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis doi:10.1080/13697137.2018.1467611 Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women doi:10.1210/jc.2010-2558

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern biohacking: sleep tracking. Moving past the mainstream obsession with daily device scores, the team breaks down the biochemical realities of how tracking your HRV might actually be sabotaging your sleep architecture. From the autonomic anxiety caused by digital wearables to the clinical application of precision chronobiology, this roundtable shifts the conversation from algorithmic scores to measurable, cellular safety signals. Join us as we delve into: The Orthosomnia Epidemic: Why waking up to a red recovery score immediately triggers your prefrontal cortex, activates your HPA axis, and flattens your diurnal cortisol curve. The HRV Paradox: Understanding the actual biological markers of Heart Rate Variability and why an algorithmic score doesn't dictate your physical reality. The Cell Danger Response: How the body is only able to sleep when it feels safe, and why the ultimate "detox" might just be a sleep divorce. Your "Do This on Monday" Protocol: Dr. Ted's clinical sleep anchoring technique, and why prioritizing sleep as the first activity of your day changes your entire circadian rhythm. Precision Cellular Nutrients: The clinical difference between taking generic sedatives and utilizing precision magnesium, glycine, and even strategic carbohydrates (like honey) to optimize GABA and melatonin. This episode is for you if: You are experiencing worsening sleep anxiety and chronic insomnia despite meticulously tracking your data every night. You want to learn how to test your cellular metabolomics for brain inflammation instead of relying on a generic smartwatch algorithm. You want to understand how your unique chronobiology dictates your sympathetic and parasympathetic balance. You can also find this episode on… YouTube: https://youtu.be/n71oG96M1Ek Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Get Myo Relax and Calm by Myoscience (20% off, code auto applied): https://bit.ly/4oWU62X  Pre-order Keto Flex Revised and get free bonuses at: https://bit.ly/4wKG1sM    You can fast, do keto, count calories, and hit the gym, and still wake up stuck with the same belly fat. The reason is almost never your daytime effort. It is what happens after your head hits the pillow. Every night your body asks one question: is it safe to burn fat? About 70 percent of your fat burning growth hormone is released while you sleep, but only if insulin is low and your deep sleep is protected. In this lesson, Ben Azadi walks through the three bedtime habits, in the exact order your body wants them, to make the next 30 nights work for your fat loss instead of against it. Key takeaways: Insulin can stay elevated three to five hours after eating, blocking your overnight growth hormone pulse In a crossover trial, a 10 p.m. dinner reduced overnight fat burning and raised cortisol versus the identical 6 p.m. meal A Mayo Clinic trial showed four hours of sleep for two weeks added 11% more visceral fat, while the scale barely moved A cold (65 to 68°F), pitch dark room and a consistent sleep and wake schedule protect deep sleep Relaxation is chemistry: myo-inositol, magnesium glycinate, potassium glycinate, glycine, taurine, GABA, and L-theanine support it The three night challenge: no late snacks, a dark cool room, and track sleep, cravings, waist, and morning energy Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is sponsored by AquaTru. AquaTru - Go to https://AquaTru.com/ now for 20% off (your purifier) using promo code FLIPPING50. AquaTru even comes with a 30-day best-tasting water guarantee. Other Episodes You Might Like: Previous Episode - Intersection of Blue Zones and Modern Muscle Science for Longevity Next Episode - 3 Workout Studies Every Woman Over 50 Needs to Know More Like This: Natural Solutions to Restorative Sleep in Menopause Is CBD the Answer? How Women Use CBD to Manage Menopause Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Get BlueSky CBD to boost your mood and motivation. Use code FLIPPING to get 20% off! The menopause motivation and mood boost you need might not come from trying harder—it may come from understanding your brain, body, and biology better.  If you've noticed more anxiety, lower motivation, brain fog, or a lack of enthusiasm for things you used to enjoy, you're not alone. In this episode, we uncover the hidden links between inflammation, brain chemistry, movement, and mood—and why so many women are overlooking it. Movement, healthy fats, community, sunlight, and even music influence the body's natural feel-good compounds that help you stay resilient through midlife and beyond.  If you're ready to feel more energized, optimistic, and in control of your health, this episode delivers powerful strategies to support your menopause motivation and mood boost. My Guest: Dr. Eric Dorninger ND, LAc is a naturopathic doctor, licensed acupuncturist, and founder of Roots and Branches Integrative Health Care in Boulder, Colorado. With a background in kinesiology, emergency medicine, naturopathic medicine, and acupuncture, he takes an integrative approach to uncovering the root causes of chronic illness. Since founding his clinic in 2005, he has specialized in helping patients with complex “mystery illnesses” by focusing on accurate diagnosis and removing obstacles to healing. He is also a certified Shoemaker practitioner with expertise in mold and biotoxin-related illness. In addition to private practice, Dr. Dorninger teaches functional medicine, practices Jiu-Jitsu, skis, and advocates for evidence-based natural medicine.  Questions We Answer in This Episode: How are inflammation, anxiety, depression, and other mood disorders connected? What are endogenous cannabinoids, and what role do they play in mood, pain, and inflammation? How do exercise and resistance training naturally boost the body's own feel-good chemicals? Why do we tend to avoid the types of exercise we need most, and how can we create better balance in our training? Can music, social connection, and community improve mood and reduce inflammation? How does CBD interact with serotonin, dopamine, and GABA to support mood, motivation, and stress resilience? What should women know before trying CBD, including product quality, dosage, safety, and realistic expectations? If this episode made you flip your workout routine — share it!

Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash -Get 15% off your next order at: https://getmte.com/dave Host Dave Asprey sits down with Jeff Boyd, founder and chairman of MTE (More Than Energy), the caffeine-free energy drink built around adaptogens, nootropics, and prebiotics that delivers what Boyd calls "energy that loves you back." Before launching MTE, Jeff spent 15 years as President and co-owner of Luggage Free, scaling the company to operations in over 100 countries before selling it in 2019. He brings the operational discipline of a veteran entrepreneur and the personal conviction of someone who built the energy product he actually wanted to exist. Dave and Jeff get into the full science and strategy behind MTE's ingredient stack, including paraxanthine, ashwagandha, eleuthero, maca, GABA, theanine, and saffron, and why each one was chosen for its role in stress response, brain optimization, and sleep optimization. They also dig into the formulation challenges of building a clean-label supplement over a stimulant base, the real difference between caffeine and its downstream metabolite paraxanthine, and why this blend functions more like a foundational biohacking protocol than a beverage. You'll Learn: Why conventional energy drinks wreck your cortisol curve and what to do instead How paraxanthine delivers the benefits of caffeine without the jitters or sleep disruption The adaptogen trio (ashwagandha, eleuthero, and maca) and how they work together for stress response and human performance Why saffron is one of the most underrated nootropics for mood and brain optimization How gut health and the microbiome connect directly to your energy, metabolism, and longevity The mitochondria connection between willpower, physical performance, and entrepreneurial output How AI is reshaping small teams and what founders need to do right now to stay competitive Why the cleanest path to anti-aging and longevity starts with how you manage your energy across the day Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Gatlan | Book your free consultation at www.gatlan.com/DAVE - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jeff Boyd, MTE, More Than Energy, caffeine-free energy, paraxanthine, adaptogens, ashwagandha, eleuthero, maca, nootropics, saffron, GABA, theanine, prebiotics, gut health, stress response, cortisol management, sleep optimization, huckleberry acai, clean label formulation, stevia Reb A, energy drink alternative, paraxanthine vs caffeine, afternoon energy, Luggage Free, cycling endurance, long jump training, ADHD entrepreneurship, AI small teams, willpower mitochondria Resources: • Get 15% off your next order at: https://getmte.com/dave • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:42 – What Is MTE? 03:50 – Ingredients Deep Dive 09:49 – Flavors & Formulation 12:31 – Dave's Caffeine Origin 18:35 – Athletic Identity 22:38 – ADHD & Entrepreneurship 26:43 – AI & Future of Work 30:47 – Willpower & Mitochondria 35:34 – MTE Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Naltrexone is often a first-line medication for AUD. It works as an opioid receptor antagonist, reducing the rewarding effects of alcohol and decreasing cravings. Patients frequently report that alcohol becomes less pleasurable while taking the medication. Oral naltrexone is typically dosed at 50 mg daily, while a long-acting injectable formulation is also available. Avoid use in patients taking opioids and use caution in significant liver dysfunction. Acamprosate helps maintain abstinence by modulating glutamate and GABA neurotransmission. Chronic alcohol use disrupts the balance between excitatory and inhibitory pathways in the brain, and acamprosate helps restore equilibrium. It is primarily eliminated renally, making it a useful option in patients with liver disease. The most common adverse effect is diarrhea. Disulfiram works through a completely different mechanism. It inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation when alcohol is consumed. This can lead to flushing, nausea, vomiting, headache, and hypotension. Because of this aversive reaction, patient motivation and adherence are critical for success. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Most people who say they've tried kava have tried a watered-down extract that feels like weak chamomile, then concluded the plant does nothing. Cameron George has spent years arguing that the real thing, whole-root and traditionally prepared, is one of the most misunderstood plant medicines on Earth. In this conversation Aubrey sits down with him for a full masterclass on what kava actually is, why the West got it so wrong, and how a South Pacific root that has anchored entire island civilizations for thousands of years might be the missing piece in the modern search for connection without self-betrayal.Kava occupies a strange category of its own. It relaxes without sedating, opens you emotionally without impairing you, and softens social armor without the crash, the fog, or the regret that follows alcohol. Cameron walks through the pharmacology behind that (the GABA upregulation, the dopaminergic support, the reverse-tolerance phenomenon where the plant becomes more effective with consistent use rather than less) and into the cultural story underneath it, including the poorly constructed studies from 1999 that nearly killed kava's reputation in the West right as it was set to break through. From there the conversation widens into nervous-system repair, the difference between borrowed relief and generative states, the role kava can play in psychedelic integration, and what it means to change your state without leaving yourself behind.Check out TRU KAVA and USE CODE AUBREY10 FOR 10% OFF►Website | https://trukava.com/►Instagram | https://www.instagram.com/trukava/This episode is sponsored by►Metal Mark Gold Aurum Collectable Art |  ⁠https://mtlmrk.com/⁠►Korrect Life | ⁠https://korrectlife.com/| Aubrey Marcus |►Website | ⁠⁠https://www.aubreymarcus.com/►Instagram | https://www.instagram.com/aubreymarcus►Facebook |⁠⁠ https://www.facebook.com/AubreyMarcus/►X |⁠ https://x.com/aubreymarcus►Substack: https://www.aubreymarcus.com/blogs/substack► Love To The Seventh Power: ⁠https://chakaruna.com/collections/books⁠Subscribe to the Aubrey Marcus podcast:►iTunes |⁠ ⁠⁠⁠⁠⁠⁠https://apple.co/2lMZRCn ⁠⁠⁠⁠⁠⁠⁠►Spotify |⁠⁠⁠⁠⁠⁠⁠ https://spoti.fi/2EaELZO ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠►IHeartRadio |⁠ ⁠⁠⁠⁠⁠⁠https://ihr.fm/3CiV4x3 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠►Partner with the Aubrey Marcus Podcast | https://www.aubreymarcus.com/pages/booking