POPULARITY
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.27.538084v1?rss=1 Authors: Megarioti, A. H., Athanasopoulos, A., Koulouris, D., Esch, B. M., Makridakis, M., Lygirou, V., Samiotaki, M., Zoidakis, J., Sophianopoulou, V., Andre, B., Froehlich, F., Gournas, C. Abstract: Quiescence is a common cellular state, required for stem-cell maintenance and microorganismal survival under stress conditions or starvation. However, the mechanisms promoting quiescence maintenance remain poorly known. Plasma membrane components segregate into distinct microdomains, yet the role of this compartmentalization in quiescence remains unexplored. Here, we show that Flavodoxin-like proteins (FLPs), ubiquinone reductases of the yeast eisosome membrane compartment, protect quiescent cells from lipid peroxidation and ferroptosis. Eisosomes and FLPs expand specifically in respiratory-active quiescent cells, and mutants lacking either show accelerated aging, defective quiescence maintenance, and accumulate peroxidized phospholipids with monounsaturated or polyunsaturated fatty acids (PUFA). FLPs are essential for the extra-mitochondrial regeneration of the lipophilic antioxidant ubiquinol. FLPs, alongside the Gpx1/2/3 glutathione peroxidases, prevent iron-driven, PUFA-dependent ferroptotic cell death. Our work is the first description of ferroptosis-protective mechanisms in yeast and introduces plasma membrane compartmentalization as an important factor for the long-term survival of quiescent cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Our next guest is Spyros Makridakis, Professor at the University of Nicosia, the director of the Institute For the Future (IFF), and an Emeritus Professor at INSEAD. Spyros is also one of the co-founders of the IIF and has significantly contributed to the field by running famous forecasting M-competitions.In this episode, we get his advice on how to build a forecasting career and why strategy is so important. He shares his opinion on the best current forecasting methods and practices. Spyros recommends some of his favourite books, Forecasting Methods for Management and Business Forecasting: Practical Problems and Solutions, along with these papers Accuracy of Forecasting: An Empirical Investigation, and A brief history of forecasting competitions.
My guest today is Spyros Makridakis, the Rector of the Neapolis University of Pafos NUP and an Emeritus Professor of Decision Sciences at INSEAD as well as the University of Piraeus and one of the world's leading experts on forecasting, with many journal articles and books on the subject. He is famous as the organizer of the Makridakis Competitions, known in the forecasting literature as the M-Competitions. His calling is to poke holes in the notion that we can forecast with accuracy. The topic is his paper Why Forecasts Fail. What to Do Instead. In this episode of Trend Following Radio we discuss: Known knowns, known unknowns, and unknown unknowns The two main types of uncertainty–“subway” and “coconut” Jim Collins, one of the best-selling business book authors of all time, and why it might not have any use to us Medicine and chance The placebo effect Acceptance of an uncertain world The illusion of control Jump in! --- I'm MICHAEL COVEL, the host of TREND FOLLOWING RADIO, and I'm proud to have delivered 10+ million podcast listens since 2012. Investments, economics, psychology, politics, decision-making, human behavior, entrepreneurship and trend following are all passionately explored and debated on my show. To start? I'd like to give you a great piece of advice you can use in your life and trading journey… cut your losses! You will find much more about that philosophy here: https://www.trendfollowing.com/trend/ You can watch a free video here: https://www.trendfollowing.com/video/ Can't get enough of this episode? You can choose from my thousand plus episodes here: https://www.trendfollowing.com/podcast My social media platforms: Twitter: @covel Facebook: @trendfollowing LinkedIn: @covel Instagram: @mikecovel Hope you enjoy my never-ending podcast conversation!
Michael Covel speaks with Spyros Makridakis on the show today. Makridakis is the Rector of the Neapolis University of Pafos NUP and an Emeritus Professor of Decision Sciences at INSEAD as well as the University of Piraeus and one of the world's leading experts on forecasting, with many journal articles and books on the subject. He is famous as the organizer of the Makridakis Competitions, known in the forecasting literature as the M-Competitions. His calling is to poke holes in the notion that we can forecast with accuracy. Covel and Makridakis discuss known knowns, known unknowns, and unknown unknowns; the two main types of uncertainty--“subway” and “coconut”; Jim Collins, one of the best-selling business book authors of all time, and why it might not have any use to us; medicine and chance; the placebo effect; acceptance of an uncertain world; and the illusion of control. Whitepapers mentioned in episode: http://www.michaelcovel.com/2015/04/23/spyros-makridakis-interview-followup. Want a free trend following DVD? Go to trendfollowing.com/win.
Today I talk with, Marney K. Makridakis, the author of Hop, Skip, Jump and founder of the online community ArtellaLand.com. You will love hearing her ideas on how to add more play into your life. Also, some apps and software I love and a song from the talented Beth Hirch. Topics covered: paper by 53, evernote, creative play Get all the links under the podcast sections at: www.craftcast.com
She is the founder of Artella Land, a groundbreaking online community for artists, writers and creative individuals. Marney is a widely known voice in the creativity movement, frequently requested for interviews, guest columns workshops and speeches. She has created hundreds of on-line workshops and courses and teaches virtual and in-person classes and workshops across the United States. She is also publisher of Artella magazine, the best selling author of Creating Time: Using Creativity to Reinvent the Clock and Reclaim Your Life. We will be discussing her new book, Hop, Skip and Jump - 75 Ways to Manifest a Meaningful Life. She shares many down-to-earth fun exercises that anyone can do starting immediately. Her book is available on www.amazon, Barnes and Noble and numerous other book stores. Contact Info for Marney www.ArtellaLand.com
About the book: Most of us view work and play as mutually exclusive opposites, but now you can blend them together in your new route to joy-filled success. The 75 techniques in this book will guide you to be more playful and productive as you move through three vital phases of the manifestation process: dreaming (Hop), experimenting (Skip), and taking action (Jump). Discover your Play Personality and learn how to use it to create more experiences in which work feels like play, and struggle gives way to momentum, ease, and joy. About the author: Marney K. Makridakis is the bestselling author of Creating Time and founder of ArtellaLand.com, the groundbreaking online community for creators of all kinds. She has trained hundreds of coaches and practitioners through the ARTbundance Certification Training program.
Marney K. Makridakis is the author of Creating Time:Using Creativity to Reinvent the Clock and Reclaim Your Life which invites readers to make dynamic, magical shifts in their lives by organically reshaping the way they think about, and use time. She founded the Artella, the groundbreaking online community for creators of all kinds and the print magazine Artella. A popular speaker and workshop leader, she created the ARTbundance, an innovative approach of self-discovery through art. Do you feel there aren’t enough hours in the day to get it all done? Creativity expert and author Marney K. Makridakis turns the concept of time management upside-down by presenting exciting new tools for experiencing time in fresh and exciting ways.
On this episode of Welcome To Blissville, Do you find yourself saying “If I only had more time” or “There’s just not enough time in the day.” Join the Bliss Lady, Teri Williams as she interviews Marny Makridakis, on Welcome to Blissville. Marney shares her story and some great tips to help open your life and your mind to creating time!
Author Marney K. Makridakis demonstrates that time is subjective. We can utilize its flexibility to lead a creative and effective life.