Circulation on the Run

This week please join author Yuxiang Dai and Associate Editor Esther Lutgens as they discuss the article "Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2–Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250623.661904

This week please join author Robert Clarke and Associate Editor Wendy Post as they discuss the article "Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250617.454324

This week please join author Nikolaus Marx as he discusses the article "Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250609.351110

This week please join author Brian Lindman and Executive Editor and Editorialist James de Lemos as they discuss the article "Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial" and the accompanying editorial "Biomarkers to Guide the Timing of Aortic Valve Replacement in Asymptomatic Aortic Stenosis: Where Do We Stand After Early TAVR?" For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250529.497472

This week please join author Varsha Tanguturi and Associate Editor Dharam Kumbhani as they discuss the article "Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: A Randomized Clinical Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250528.505920

This week please join author André Zimerman and Associate Editor Amit Khera as they discuss the article "Intensive Lowering of LDL Cholesterol Levels With Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250519.268826

This week please join author Milind Desai and Associate Editor Mark Link as they discuss the article "Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results From VALOR-HCM."  For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250512.476310

This week please join author Jarett Berry as well as Guest Editor and Editorialist Paul Thompson as they discuss the article "High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250505.656863

This week please join author Bin Zhou and Associate Editor Zhao Wang as they discuss the article "Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250428.805646

This week please join author Signe Glargaard and Associate Editor Justin Ezekowitz as they discuss the article "A Randomized Controlled Trial of Thoracentesis in Acute Heart Failure." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250421.239148

This week please join author Emmanuel Stamatakis and Associate Editor Jarett Berry as they discuss the article "Dose Response of Incidental Physical Activity Against Cardiovascular Events and Mortality." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250414.213483

This week please join author Barry Borlaug and Associate Editor Torbjørn Omland as they discuss the article "Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250407.806254

This week please join author Josef Stehlik as he discusses the article "Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250331.87307

This week please join author Josefine Windfeld-Mathiasen and Associate Editor Ntobeko Ntusi as they discuss the article "Cardiovascular Disease in Anabolic Androgenic Steroid Users." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250324.957173

This week please join author Eric Rosenthal and Associate Editor Gerald Greil as they discuss the article "Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20250317.309077

This week please join author Michael Zile and Associate Editor Justin Ezekowitz as they discuss the article "Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250307.892170

This week please join author Yugo Yamashita and Associate Editor Joshua Beckman as they discuss the article "Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial)." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250303.648421

This week please join author Carl Johann Hansen and Associate Editor Mark Link as they discuss the article "Declining Trend of Sudden Cardiac Death in Younger Individuals: A 20-Year Nationwide Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250224.873552

This week, Circulation celebrates Go Red for Women with its 9th annual special issue. Guest hosts Sana Al-Khatib and Mercedes Carnethon welcome authors Upasana (Paz) Tayal as well as Thais Coutinho and coauthors. Circulation on the Run also welcomes the American Heart Association's President Keith Churchwell. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250217.870159

This week please join author Michael Zhang and Guest Editor Paul Gurbel as they discuss the article "Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS." For the episode transcript, visit: https://www.ahajournals.org/do/110.1161/podcast.20250210.487047

This week please join author Paul Welsh and Guest Editor Manuel Mayr as they discuss the article "A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250203.163969

This week please join author Hayley Dillon and Editorialist Justin Canada as they discuss the article "Preventing Allogeneic Stem Cell Transplant−Related Cardiovascular Dysfunction: The ALLO-Active Trial" and the Editorial "Cardiorespiratory Fitness Assessment in Stem Cell Transplant Recipients: Getting to the Heart of the Problem." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250127.949759

This week please join author Olaf Bergmann as he discusses the article "A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20250121.427979

This week please join author Helga Gudmundsdottir and Editorialist James MacNamara as they discuss the article "Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial" and the accompanying Editorial "Cardiac Plasticity in Hypertrophic Cardiomyopathy: Exercise as Medicine?" For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250113.568188

This week please join author Kieran Docherty and Associate Editor Justin Ezekowitz as they discuss the article "Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20250106.356679

This New Year's week, please join Social Media Editor Pishoy Gouda as he interviews corresponding author Alexander Fanaroff to discuss the 2024 Willerson Award-winning article "Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20241227.771393

This week please join Circulation on the Run's newest host, Anezi Uzendu, author Boris Schmidt, and Associate Editor Andrea Russo as they discuss the article "Ablation Strategies for Repeat Procedures in Atrial Fibrillation Recurrences Despite Durable Pulmonary Vein Isolation: The Prospective Randomized ASTRO AF Multicenter Trial." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20241216.546751

This week offers a double-feature of author interviews. First, please join author Gregg Stone as he discusses the article "Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial." Then, please join author Sung-Min Cho and our Circulation on the Run podcast host Greg Hundley as they discuss the article "Clinical Use of Bedside Portable Ultra-Low-Field Brain Magnetic Resonance Imaging in Patients on Extracorporeal Membrane Oxygenation: The Results From the Multicenter SAFE MRI ECMO Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241209.320025

This week, please join authors Amil Shah and our own Peder Myhre, as well as Guest Editor Allan Jaffe as they discuss the article "NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241202.603271

This week, please join author Robert Shaddy and Senior Associate Editor Victoria Delgado as they discuss the article "Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-blind Trial." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20241125.19126

This week, please join author Gilles Montalescot, Editorialist John Carroll, and Associate Editor Dharam Kumbhani as they discuss the article "Flecainide to Prevent Atrial Arrhythmia after Patent Foramen Ovale Closure, the AFLOAT Study: A Randomized Clinical Trial" and the Editorial "Atrial Arrhythmias After PFO Device Closure: Common, Clinically Important, and Preventable?". For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241115.222442  

This week, please join author Nigopan Gopalasingam, Editorialist B. Daan Westenbrink, and Associate Editor Justin Ezekowitz as they discuss the article "A Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction" and the editorial "Ketone Treatment in Heart Failure With Preserved Ejection Fraction: Recharging the Heart or Reducing Filling Pressures?". For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241111.585567

This week, please join author Kashish Goel and Associate Editor Dharam Kumbhani as they discuss the article "Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241104.791174

This week, please join authors Regina Royan and Tracy Madsen as well as Associate Editor Deborah Diercks as they discuss the article "Disparities in Emergency Medical Services Use, Prehospital Notification, and Symptom Onset to Arrival in Patients with Acute Stroke." For the episode transcript, visit: https://www.ahajournals.org/do/110.1161/podcast.20241028.477927

This week, join Associate Editor Marc Ruel who briefly summarizes Circulation's annual Surgery Issue. Then he is joined by author André Lamy and they discuss the article "Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial." Then Marc is joined by author Niccolò Maurizi and they discuss the article "Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20241018.445322

This week, please join authors Shaan Khurshid and Shinwan Kany as they discuss the article "Associations of ‘Weekend Warrior' Physical Activity With Incident Disease and Cardiometabolic Health." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241003.112753

This week, please join author Luigi Di Biase as he discusses the article "Pulsed Field Ablation to Treat Paroxysmal Atrial Fibrillation: Safety and Effectiveness in the ADMIRE Pivotal Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241003.273130

This week, please join author Marcelo Di Carli and Associate Editor Vlad Zaha as they discuss the article "Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension."

This week, please join author Chen Chen and Associate Editor Sergio Lavandero as they discuss the article "LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240920.99651

This week, please join a panel session with authors Timothy Poterucha and David Ouyang, Editorialist Anna Sannino, and Senior Associate Editor Victoria Delgado as they discuss the Original Research Articles "Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR)" and "High-Throughput Deep Learning Detection of Mitral Regurgitation." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240916.127413

This week, please join author Bruce Wasserman and Associate Editor Mercedes Carnethon as they discuss the article "Intracranial Atherosclerotic Disease and Incident Dementia: the Atherosclerosis Risk in Communities Study (ARIC)." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240906.944975

This week, please join author Gregory Wyant and Associate Editor Gabriele Schiattarella as they discuss the article "Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240830.316198

This week, please join author Gary Owens and Associate Editor Iris Jaffe as they discuss the article "A Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240825.966308

This week, please join author Marius Hoeper and Associate Editor Kelly Chin as they discuss the article "Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized, Controlled Phase 3 Study." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240816.125469

This week, please join author Rachel Lampert as she discusses the article "Vigorous Exercise in Patients with the Congenital Long-QT Syndrome: Results of the Prospective, Observational, Multinational, LIVE-LQTS Study.” For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240809.114150

This week, please join author Hiroyuki Daida and Associate Editor Amit Khera as they discuss the article "A Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy−Statin and Eicosapentaenoic Acid (RESPECT-EPA)." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240804.906883

This week, please join author Rod Passman and Associate Editor Mark Link as they discuss the article "Association of Atrial Fibrillation Burden and Mortality Among Patients With Cardiac Implantable Electronic Devices." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240729.689092

This week, please join author John J.V. McMurray and Guest Editor Frank Ruschitzka as they discuss the article "Effect of Sacubitril/Valsartan on Cognitive Function in Patients With HFpEF: A Prespecified Analysis of PARAGON-HF." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240719.555489

This week, Circulation is proud to present the 4th annual Disparities issue. First, Guest Editor Latha Palaniappan leads the interview with author Jennifer Green as they discuss the article "Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial." Then, Disparities Editor Mercedes Carnethon talks with author Benjamin Zielonka about his article "Childhood Opportunity and Acute Interstage Outcomes: A National Pediatric Cardiology Quality Improvement Collaborative Analysis." Finally, Dr. Karol Watson leads the discussion with author Lisa Cooper regarding her article "Equitable Care for Hypertension: Blood Pressure and Patient-Reported Outcomes of the RICH LIFE Cluster Randomized Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240712.517573

This week, please join first author Heerajnarain Bulluck as he discusses the article "Effect of Cangrelor on Infarct Size in ST-Segment−Elevation Myocardial Infarction Treated By Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (The PITRI Trial)." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20240703.90241

This week, please join authors Reza Nezafat, Shiro Nakamori, and Amine Amyar as they discuss the article "Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240628.66549