Podcasts about ldl

In episode 56 of Going anti-Viral, Dr Steven Grinspoon joins host Dr Michael Saag to discuss managing cardiovascular health in people with HIV. Dr Grinspoon is a clinician in the Neuroendocrine and Pituitary Tumor Clinical Center and faculty member at the Massachusetts General Hospital, and a Professor of Medicine at Harvard Medical School. He is a clinical researcher who studies hypothalamic control of body weight and fat distribution in obesity and lipodystrophy with a focus on the metabolic and cardiovascular consequences of visceral fat accumulation. Dr Grinspoon provides an overview of cardiovascular disease in people with HIV including a review of the REPRIEVE study that evaluated if statin medication is effective to prevent heart disease among people with HIV. Dr Saag and Dr Grinspoon detail the REPRIEVE study results demonstrating that statins lower baseline low-density lipoprotein (LDL) cholesterol levels and discuss the cardiovascular health benefits of lowering LDL cholesterol levels. They discuss arterial plaque, how it is measured and whether plaque can regress individuals on statins. Finally, Dr Saag and Dr Grinspoon discuss goals for follow-up studies to REPRIEVE and other studies looking into the benefits of statins in other populations.0:00 – Introduction1:28 – Overview of cardiovascular disease in people with HIV 3:23 – Overview of the REPRIEVE study, which evaluated if statin medication is effective to prevent heart disease among people with HIV10:51 – REPRIEVE study results lowering baseline LDL cholesterol                       13:26 – Follow-up studies in people who do not have HIV16:20 – How plaque is measured in the arteries19:40 – Regression of plaque in patients using statins 21:15 – Top goals for follow-up studies to REPRIEVEResources: REPRIEVE Study: https://www.reprievetrial.org/ __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...

Send us a textDr. Josh Wageman is a Clinical Lipid Specialist with multiple doctoral degrees who formerly practiced in Endocrinology. His PhD work focused on cholesterol disturbances in Alzheimer's Disease, and although he also has a Doctorate in Physical Therapy, he is best known for his role in teaching lipid physiology.He serves as an adjunct professor at several medical programs and his goal is to help you, whoever you are, NOT have heart attacks, strokes, and dementia by explaining complicated biochemical concepts in a relatable way!Employing a smorgasbord of metaphors, pictures, and catchphrases, his latest book The Home Security System and the Lipid Neighborhood serves as a valuable reference for clinicians and non-clinicians alike, bringing refreshing relatability to complex biochemical topics. Through a lipid-lens, you'll learn, laugh, and love your way through its pages…and in the end, you'll undoubtedly add “life to your years!”Dr. Josh Wageman is active in Youth Ministries at Heritage Bible Church in Boise, Idaho, and resides there with his family. He also enjoys Crossfit, basketball, Ultimate Frisbee, and all sports that don't involve skates.Find Dr. Wageman at-Amazon- The Home Security System and the Lipid Neighborhood IG- @wagemanjoshLK- @Josh WagemanFind Boundless Body at- myboundlessbody.com Book a session with us here!

For years, eggs have been breakfast's most controversial ingredient. Despite being packed with protein and essential nutrients, they've carried the weight of dietary guidelines that linked them to high cholesterol and an increased risk of heart disease. But a new study published in The American Journal of Clinical Nutrition has cracked that myth wide open. The world-first study investigated the independent effects of dietary cholesterol and saturated fat on LDL cholesterol levels. The results: it's not the cholesterol in eggs that's the problem, it's the saturated fat in other parts of our diet, like bacon and sausages. In this controlled trial, researchers assigned participants to diets with varying combinations of cholesterol and saturated fat. In one group, participants consumed two eggs per day as part of a high-cholesterol but low-saturated-fat diet. In another, participants ate high-saturated-fat, low-cholesterol meals. A third group consumed both high saturated fat and high cholesterol. What they found was surprising: LDL cholesterol only rose in diets high in saturated fat regardless of dietary cholesterol intake. But when cholesterol came from eggs in the absence of excess saturated fat, LDL levels actually dropped slightly. This is an important finding because it challenges long-held assumptions in nutritional science. For decades, dietary cholesterol (often from eggs) was lumped in with saturated fats as a heart health hazard. But as this study demonstrates, the two have very different effects on the body. Eggs contain around 186 mg of cholesterol per yolk, which historically raised alarms. However, they are very low in saturated fat (about 1.6 grams per large egg). Saturated fats found in processed meats, butter, and fried foods are the true drivers of increased LDL cholesterol, which is strongly associated with cardiovascular disease. The study reaffirms a growing body of evidence that dietary cholesterol has minimal impact on blood cholesterol in most people, especially when consumed as part of a healthy, balanced diet. The key takeaway isn't just that eggs are safe, it's that context matters. A couple of eggs at breakfast is fine. A couple of eggs alongside bacon, sausages, and buttered toast? Not so much. It's the overall pattern of your diet, not individual foods, that makes the biggest difference to your heart health. So feel free to enjoy your poached, scrambled, or sunny-side-up eggs. Just remember: it's the saturated fat, not the eggs, that's more likely to scramble your cholesterol. LISTEN ABOVESee omnystudio.com/listener for privacy information.

 Today on Beating Cancer Daily, Saranne welcomes back functional medicine expert Jacqui Bryan for an in-depth look at berberine—a natural compound generating major buzz as “Nature's Ozempic” on platforms like TikTok. With excitement high from both Saranne and Jacqui, the conversation explores berberine's traditional use in Chinese and Ayurvedic medicine, its modern reputation for supporting blood sugar control, heart health, weight management, cognitive function, and even potential anti-cancer qualities. Saranne highlights the supplement's growing popularity among those seeking natural alternatives to pharmaceuticals and underscores the importance of professional guidance before starting any supplement, especially for those navigating cancer, like survivors who are wary of synthetic drugs or those living with conditions such as Stage IV cancer.Jacqui Bryan is a certified nutrition specialist, whole health educator, certified health coach, and registered nurse. Her multidisciplinary, functional medicine background empowers others to take charge of their health through evidence-based, holistic approaches. Jacqui is passionate about translating the latest research into practical wellness strategies and is known for her ability to make complex topics both accessible and actionable for those managing chronic illness or seeking better overall health.“I love it when we can find things in nature that can improve our health, which I think is a lot of what we've been doing with this podcast.” ~Jacqui BryanToday on Beating Cancer Daily:·     Berberine is a natural plant compound with a long history in traditional medicine, now being explored for its impacts on metabolism, blood sugar, and even cancer. ·     The supplement is often compared to pharmaceuticals like Ozempic and metformin, generating popularity as a “natural” alternative, especially for those hesitant to use synthetic drugs. ·     Berberine's most studied effects include blood sugar regulation, enhancing insulin sensitivity, and supporting energy production at a cellular level. ·     Its role in gut health is significant, potentially supporting microbiome diversity, improving digestion, and providing relief for conditions such as SIBO. ·     Potential heart health benefits include lowering LDL (bad) cholesterol and triglycerides, and possibly increasing HDL cholesterol, though results may be stronger for women. ·     Proper use—including dosing, timing (typically before meals), and supplement quality, should always be discussed with a healthcare provider, given potential drug interactions and contraindications. ·     Berberine is not suitable for everyone, especially those who are pregnant, breastfeeding, on statins, or already using GLP-1 medications. ·     Reevaluating supplement routines regularly and coordinating with medical teams is critical to ensure safety, efficacy, and the avoidance of unnecessary or harmful combinations. 2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Potato intake and diabetes risk.How much daily leucine is required to regain muscle?

I have high LDL cholesterol and a '0' calcium score.  Why does my doctor insist I take a statin?How much vitamin D should I take?  Which product do you recommend?Some doctors assert omega-3s are proinflammatory.  What say you?Study: Magnesium intake may be beneficial in preventing pancreatic cancerDo you have any products to regrow hair?I have a calcium score, but prefer to avoid Lipitor.

You're listening to Burnt Toast! Today, my guest is Mara Gordon, MD.Dr. Mara is a family physician on the faculty of Cooper Medical School of Rowan University, as well as a writer, journalist and contributor to NPR. She also writes the newsletter Your Doctor Friend by Mara Gordon about her efforts to make medicine more fat friendly.Dr. Mara is back today with Part 2 of our conversation about weight, health, perimenopause and menopause! As we discussed last time, finding menopause advice that doesn't come with a side of diet culture is really difficult. Dr Mara is here to help, and she will not sell you a supplement sign or make you wear a weighted vest.This episode is free but if you value this conversation, please consider supporting our work with a paid subscription. Burnt Toast is 100% reader- and listener-supported. We literally can't do this without you.PS. You can always listen to this pod right here in your email, where you'll also receive full transcripts (edited and condensed for clarity). But please also follow us in Apple Podcasts, Spotify, Stitcher, and/or Pocket Casts! And if you enjoy today's conversation, please tap the heart on this post — likes are one of the biggest drivers of traffic from Substack's Notes, so that's a super easy, free way to support the show!And don't miss these:Episode 209 TranscriptVirginiaSo today we're going to move away from the weight stuff a little bit, into some of the other the wide constellation of things that can happen in menopause and perimenopause. Before we get into some nitty gritty stuff, I want to do Laurie's question about hormone replacement therapy, since that is still one of those topics that people are like, Is it good? Is it bad? I don't know.So Laurie asked: Is there a reason why a doctor would not want to prescribe hormone replacement therapy? My doctor seems more willing to treat individual symptoms instead of using HRT. Is that maybe because I'm still getting my period?MaraI love this question. Now my professor hat can nerd out about interpretation of scientific research! So first, I'll just briefly say, Laurie, no big deal that you said HRT. But just so everyone's aware, the preferred term is menopausal hormone therapy, MHT, or just hormone therapy, and it's not a huge deal. But I think the North American Menopause Society now uses “menopausal hormone therapy.” The thinking is, hormones don't necessarily need to be replaced. It comes back to that idea of, menopause is a natural part of life, and so the idea that they would need to be replaced is not totally accurate. VirginiaWe're not trying to get you out of menopause, right? The goal isn't to push you back into some pre-menopausal hormonal state. MaraBut again, not a big deal. You'll see HRT still used, and a lot of doctors still use that term. So I graduated from medical school in 2015 and I remember one of the first times that a patient asked me about using menopausal hormone therapy, I was terrified. And I was still in training, so luckily, I had a mentor who guided me through it. But I had absorbed this very clear message from medical school, which is that menopausal hormone therapy will cause heart disease, cause pulmonary emboli, which are blood clots in the lungs, and cause breast cancer.And I was like, “Ahhh! I'm gonna cause harm to my patients. This is scary.” I had also learned that hot flashes–they weren't life threatening. So a patient could just use a fan and she'd be fine, right? She didn't need medicine for it.VirginiaCool.MaraI think the dismissal of symptoms here is just straight up misogyny. That message of, oh, you should just live with this You're tough, you're a woman, you can do it. This is just the next stage of it. Is just misogyny, right?But the fear of using menopausal hormone therapy has a specific historical context. There was a major study called the Women's Health Initiative, and it was a randomized control trial, which is the gold standard in medical research. People were given estrogen and progestin to treat menopausal symptoms or they were given a placebo, and they didn't know which pill they took. But WHI was actually halted early because they found an increased risk of breast cancer. This was on the front page of The New York Times. It was a really, really big deal. That was 2002 or 2003. So even 15 years later, when I was starting out as a doctor, I was still absorbing its message. And I think a lot of doctors who are still in practice have just deeply absorbed this message.But there's a lot to consider here. The first issue is in the way that information about the Women's Health Initiative was communicated. Nerd out with me for a second here: There is a big difference between absolute risk and relative risk. And this is a really subtle issue that's often communicated poorly in the media.So I looked it up in the initial paper that came out of the Women's Health Initiative. There was a relative risk of 26 percent of invasive breast cancer, right? So that meant that the people who got the estrogen and progestin, as opposed to a placebo, had a relative increased risk of 26 percent compared to the placebo arm.VirginiaWhich sounds scary,MaraSounds terrifying, right? But the absolute risk is the risk in comparison to one another. And they found that if you're a patient taking the estrogen/progestin, your absolute risk was 8 people out of 10,000 women a year would get invasive breast cancer. So it's very, very small.And this is an issue I see in medical journalism all the time. We talk about relative risk, like your risk compared to another group, but the absolute risk remains extremely low.And just to round it out: I looked all this up about cardiovascular events too. Things like a heart attack, a stroke. So the absolute risk was 19. So there were 19 cases of a cardiovascular event out of 10,000 women in a year. People just freaked out about this because of the way that it was covered in the media. VirginiaI was fresh out of college, doing women's health journalism at the time. So I fully own having been part of that problem. We definitely reported on the relative risk, not the absolute risk. And I don't understand why. I look back and I'm like, what were we all doing? We ended up taking this medication away from millions of women who could really benefit from it.MaraI found a paper that showed between 2002 and 2009 prescriptions for menopausal hormone therapy declined by more than 60 percent. VirginiaI'm not surprised. MaraAnd then even up until the time I started my training, right in 2015, we're just seeing a huge decline in hormone therapy prescriptions.One other thing that's also super important to acknowledge about the Women's Health Initiative is that they enrolled women over 60, which is not really representative of women who want or need hormone therapy. So the average age of menopause is 51 and the vast majority of women who are experiencing symptoms that would respond well to hormone therapy are much younger. We're talking here mostly about hot flashes. Which we call vasomotor symptoms of menopause, but it's basically hot flashes. Women dealing with this are much younger, right? So they're approaching menopause, late 40s, and right after the menopausal transition, early 50s, and then they don't necessarily need it anymore, after their symptoms have improved.VirginiaAnd it will also be true that with women in their 60s, you're going to see more incidence of cancer and heart disease in that age group than in women in their 40s anyway, right? MaraRightVirginiaSo even the 19 cases, the eight cases—they were looking at a higher risk population in general. MaraYeah. And so there have been all these subsequent analyses, which is why now we're seeing menopausal hormone therapy sort of on the upswing. There's a lot of increased interest in it. The American College of Obstetricians and Gynecologists recommends it, the North American Menopause Society, the British Menopause Society; here's a full run-down. It's not that everybody needs it, and we'll get to that in a second, but it is a totally safe and appropriate treatment for—specifically and most importantly—for vasomotor symptoms of menopause. Like hot flashes. There's been all these further analyses of the Women's Health Initiative data and and then from other studies, too. And basically, it shows that when the hormone therapy is initiated before age 60, or within 10 years of menopause, there's a reduced risk of heart disease and reduced mortality.VirginiaWow! MaraSo the timing matters. Isn't that so interesting? The timing matters.Also, the route of administration matters. So what that means in English is that an estrogen patch seems to have a lower risk of blood clots. So one of those fears of the, you know, initial Women's Health Initiative data was that you might have an increased risk of blood clots. But it's something about the way that the estrogen is metabolized. It's not metabolized through the liver when it's absorbed through the skin, and something about that process seems to decrease the risk of blood clots.So that's why your doctor, if you're interested in menopausal hormone therapy, might recommend an estrogen patch rather than a pill.VirginiaGot it. MaraThere's a lot of ambiguity in all of this data, because, you know, we're talking about just huge numbers of people, and it's hard to sort of isolate variables when you're studying just like massive cohorts of people and trying to understand what you know, what factors affect your risk for which diseases. It's not clear that taking hormones prevents heart disease. And that's one of the big claims I see with menopause influencers, that every single person needs this.The data don't support it at this point in time, and the major menopause organizations do not recommend it as a universal preventative treatment for everybody. But it seems like there might be some sort of association that may become clearer as research continues. That said, now it seems like the pendulum is swinging in the opposite direction. I learned, “be afraid of menopausal hormone treatment.” And now all these menopause influencers are saying everyone should be on hormone therapy.I don't know the answer. And so the way that I try to parse through all of this noise is, you know, go to trusted sources, right? So I stick to society guidelines, like the North American menopause society, the British menopause society, they're run by world experts in menopause.VirginiaOkay, so we don't need to be terrified of hormone therapy, and you can be on it if you're still getting your period right? Just to finish Laurie's question.MaraIf you're still getting a period regularly, you're more in perimenopause than past the menopausal transition. And we will often use contraception to help and that you can have a lot of the same benefits from using contraception in that stage. It's also useful just because unintended pregnancy still can be totally a thing in your 40s. But yes, you can absolutely use traditional regimens of menopausal hormone therapy while you're still getting a period too. Just know it won't prevent pregnancy. VirginiaSince we talked a little bit about hot flashes, I'm gonna jump to Judy's question so we can kind of round that piece out: One of the things I am really struggling with is the way I have lost all ability to regulate temperature. I am boiling hot almost all the time, and the slightest thing makes me break out into a full sweat, which makes me not want to move at all.My doctor has not been super helpful in navigating this. What can I do to mitigate this issue? If anything, it is so very hard for me not to blame the size of my body for this, since the correlation seems so clear, smaller body less sweating, larger body sweating all the dang time.MaraJudy, I empathize first of all. Just one caveat I can't really give medical advice to Judy. There are a lot of things that could be going on, and it's really important that you see a doctor and get a full history and physical exam. But I will say that this is one of the things that menopausal hormone therapy is extremely helpful for, is hot flashes.VirginiaThat was my first thought! MaraThere are a lot of influencers who really overstate the benefits of hormone therapy, right? Hormone therapy is not really going to cause significant weight loss or prevent weight gain. It's not totally clear that it helps with mood symptoms or even sleep is a little more ambiguous. But the one thing it really works for is hot flashes. So that would be my thought: Start there. VirginiaAnd on the feeling like you want to blame your body for it: I don't know if Judy identifies as fat, but as someone who identifies as fat, I often feel like I'm sweatier now than when I was thinner. I run warmer. All my skinny friends will be bundled up in coats, and I still won't be wearing one in October. I do notice that. And I think that this is a situation where that is, even if those two things correlate— you're larger and you're sweatier—is that worth putting yourself through the hell of weight loss? You may decide yes, it is, if hormone therapy doesn't work for you.But that's one of those times where I bring it back to “What would actually make my daily life miserable?” I can drink water, I can be in AC, I'm gonna find a link to this nighttime cooling bed thing that my friend Claire Zulkey really loves. MaraI've heard of those!VirginiaI think there are options to mitigate your suffering with this. Medicine is definitely an option. Before you go to “okay, my body size has to be the thing that changes.”MaraI totally agree. I just deal with this all the time where people tell me in my clinic that they want to lose weight. And when I sort of gently ask, what are you hoping to achieve? What are your goals? They're often things that can be achieved through other means. Like, people say my clothes don't fit, right? And most of my patients are low-income, right? I'm not trying to be flippant about the idea that everyone can just go and purchase a new, you know, multi $1,000 wardrobe at the drop of a hat. But it is possible to get new clothes in affordable ways. Don't torture yourself with clothes that don't fit because you feel like weight gain is a moral failing. And I think that there are things that we can do to help keep us at a comfortable temperature, right wear clothes that feel, you know, that feel good. Air conditioning is an amazing modern invention. And, you know, cool beverages, ice cream. VirginiaPopsicle O'Clock is very important in my summer right now, very important. MaraWait, what's a popsicle clock?VirginiaOh, Popsicle O'Clock. It's just the time of day where you eat popsicles. It could be 9am it could be 4pm just whenever I feel like we need to add popsicles to a situation.MaraI think we all need more popsicles in our life, that is absolutely for sure.So I think what I'm hearing from Judy's question is once again, shame about body size, and also this myopic zooming in on weight loss as the only possible solution. Which I blame doctors for in many ways! Some people do benefit from weight loss, right? I'm not opposed to the idea that anybody would ever want to lose weight. I don't think that that's a betrayal of fat solidarity, necessarily. But that there are other things you can do just to make your life feel better in the meantime, or even if you choose to never pursue weight loss. There are things you can do to feel better, and we shouldn't deprive ourselves of those things.VirginiaAnd you don't know that it is the weight gain. It could be age and hormones, and those coincided with the weight gain for you personally. But there are lots of thin women getting hot flashes all the time too.Okay, this next question is from Michaela: I am super curious about the connection between perimenopause, menopause and mental health symptoms, specifically, an uptick in anxiety and depression. Is this a thing?We also got many questions about whether perimenopause and menopause exacerbate ADHD symptoms. MaraSo this is a question I get a lot from my patients, and I've seen a lot of discourse about online. And the short answer is: There is probably a connection between the hormonal changes of perimenopause and the menopausal transition and mental health. Do we understand it? No. So I mean, with ADHD specifically, I will say: This is really not my area of expertise. It's a very complex mental health condition, and our medical understanding of it is really rapidly evolving. I have many patients who have a diagnosis of ADHD but I'm typically not the one who diagnoses them. That being said: Estrogen affects neurotransmitters. Neurotransmitters are implicated in ADHD. Declining estrogen does seem to affect dopamine, in particular, which is implicated in ADHD. And anecdotally, I've had many of my patients say that they feel like their ability to focus and sustain attention decreases. And they experience brain fog as they enter perimenopause and menopause. So it's there's probably something going on, and a lot of researchers are really actively studying it, but we don't know yet.VirginiaDo we know if this is something that hormone therapy can help with?MaraSo I think the answer is, I don't know.VirginiaWhat about anxiety and depression?MaraI don't think the data are there, right? Hormone therapy is usually not considered a first line treatment for the mental health conditions that are often associated with the menopausal transition. But we have great medicines for those conditions. We have good treatments for ADHD, we have good treatments for anxiety and depression. And sometimes during the menopausal transition, patients might need an increase of those treatments. And that could mean going back into therapy, if you've been out of therapy, increasing your medications or restarting a med that you may have stopped years ago. Those are all totally valid approaches during this phase.And I guess what I'd say, is that it's okay to trust your body. And if you notice changes in your mental health associated with perimenopause or menopause itself, ask about it. Don't be afraid to advocate for yourself. And while hormone therapy doesn't look like it is an effective treatment specifically for those symptoms, there are other treatments, and you should feel empowered to ask about them.VirginiaThe next question goes back to some of the diet and exercise stuff we've touched on. This person writes: Since recently reaching menopause, my cholesterol has become high. I understand there is a proven link between menopause and increased cholesterol, and that weight is part of the picture. I'm trying to lower my cholesterol with focus on nutrition and exercise. But it is f*****g with my head because it feels like a very restrictive diet. I'd love any thoughts on the menopause cholesterol connection and keeping cholesterol low with nutrition and exercise without falling into the abyss of obsessing about how many almonds I've eaten.MaraOh, that is such a good question!VirginiaThe almond of it all. MaraAlmonds are really good in some scenarios, but also just like, kind of a sad snack. I always think about President Obama eating those, like, eight almonds, or whatever.VirginiaIt turns out that was a joke and he wasn't doing that. But just the fact that everybody assumed he would says a lot! MaraThat is hilarious, and I didn't know! And it just shows how with information online, the initial story sticks. Like to this day, 10 years later, I still thought that Barack Obama ate eight almonds as his indulgent midnight snack every single night. I hope the man is eating some ice cream and living his best life. Okay, so there is absolutely a link between menopause and elevated risk of cardiovascular disease. But even within the term cholesterol, there are different types. I wouldn't really say to a patient, “Your cholesterol is high.” One thing you might hear is “your LDL cholesterol is high,” which is known popularly as, the “bad” cholesterol. Which, again, moral language alert. But LDL cholesterol is a proxy for risk of cardiovascular disease. I will say it's not a great one; it's kind of a blunt instrument. We measure and we treat it, because we don't have other great ways of predicting cardiovascular risk. But it is not the full portrait, although it's certainly a risk factor for developing cardiovascular disease. And the transition of menopause seems to impact LDL, cholesterol, other biomarkers of cardiovascular disease, and increases your risk for cardiovascular disease.And what's interesting–I think we talked about this a little bit already, is that this happens, this this risk happens independent of normal aging.So, for example, women who go through menopause early start developing this increased risk earlier than women who go through menopause slightly later. And overall, we see that women develop cardiovascular disease, at rates lower than men, and at later in life than men. And there's a hypothesis that this has to do with menopause, right? That there's a protective effect of estrogen, but then when your estrogen starts to decline in menopause, it puts women at an increased risk compared to where they were pre-menopause.There's also some data to suggest that the severity of menopause symptoms—particularly vasomotor symptoms like hot flashes or sleep disturbances—may indicate risk for developing cardiovascular disease. So this is not to scare everyone, but it's good to have knowledge. If you're having really severe hot flashes, it may indicate that you are at slightly higher risk for developing cardiovascular disease than somebody who is not. The intention of having this knowledge is not to make you feel shame, and not to berate you for your belly fat or whatever. It's to have knowledge so that you can help mitigate risk factors in ways that feel aligned with your values and ways that feel aligned with the way that you want to pursue health in your life.And so I would approach this reader's or this listener's question with smy same approach to all of my patients questions. “I have hypertension, does that mean I need to lose weight?” “I have diabetes, does that mean I need to lose weight?” The answer is that we have many treatments that can help you address these concerns independent of weight loss. But this is not to say that you cannot pursue weight loss too, right? And if using a GLP-1 agonist to reduce your visceral adiposity is aligned with your values, and you can tolerate the side effects, and you feel good about it, and it's covered by your insurance….that's totally a reasonable approach. But it's not the only one. So I think what I'm hearing from this patient is the menopause flavor of what I do every single day in my work as a size inclusive doctor. Which is: How can we disentangle weight stigma and body shame from these questions of how to lead a healthy life? And the idea of giving you more information, I hope, is not to shame you or make you feel guilt for the relationship between body size and risk of cardiovascular disease, but instead, to give you information that might help you take proactive care of your body, right?And proactive care might mean committing to an exercise routine. Proactive care might mean taking a statin. A statin is a very common cholesterol medicine like Lipitor. It might mean getting your blood pressure under control and taking an antihypertensive.VirginiaI also want to say on cholesterol, specifically, I did a piece that I'll link to digging into the connection between nutrition and cholesterol. And the data is not as strong as I think a lot of doctors are telling folks.And I think the benefit of making dietary changes—the amount it could lower cholesterol—was not huge. It was like three points or six points or something in one of the studies we looked at. So if it's making you crazy to count almonds, it's possible that medication might be a more health promoting strategy for you. Because it will be less stressful and it will have a bigger benefit on your cholesterol than just trying to control it through diet and exercise.MaraYeah, I totally agree. I think there's a really strong genetic component that we haven't fully understood and medication is a totally reasonable approach and very safe approach. Honestly, statins are pretty benign medications. They're pretty inexpensive, pretty minimal side effects, which is not to say– nobody's paying me from the statin companies, I swear to God!–but yeah, like they're, they're pretty benign as medications go. And I think it's a totally reasonable way to approach this issue.VirginiaI just think it's one of those times where this is shame coming in, where it's like, “You should be able to fix this with how you eat and exercise, and so you don't get the medication unless you fail at that!” This is a framing that I've encountered from doctors. But what if we gave the medication, what if we also consider diet and exercise, but don't make that a pass/fail situation in order to earn the medication? MaraYeah, that's really interesting.And even the language you're using Virginia is what we use in the medical record, and I've tried to stop it. But the way we're taught to describe patients, is “patient failed XYZ treatment,” right? And I feel like we're both at once, overly invested in pharmaceutical treatments, right and underinvested. They're a very useful tool. And we moralize it, both pro and con? Sometimes, like, we moralize in favor of it. So if your BMI is 26 or above, you need to be on a GLP one agonist, which is just false, right?But on the other hand, I think we often underutilize medications because there's this sense that you're getting at —that you have to exhaust all of your like willpower options first, and it's somehow failing to use a med. And that is really false too. They're really useful tools. Science is really useful, and we shouldn't feel ashamed to use it.VirginiaAll right. And our last question, I like because it just will give us a chance to kind of sum up some key points: As a post menopausal woman, I feel like I'm swimming in information, and I'm overwhelmed by it all. What are Dr Gordon's top three pieces of advice out of all of the WHO meaning, if women at this time only did these three things, it would make the biggest difference, and then they just had it. You know, is, does it need to be different for perimenopause versus post menopause? Or maybe not.So what are your top three? Top three tips for surviving this life stage?MaraOh, my God, if only I knew! I'm flattered that you're asking, and I will do my best to answer, but I don't think there's a right answer at all.So I've thought about a couple things. I will say that, you know, longevity and wellness and health span is extremely complicated, but it's also kind of simple, right?So sometimes the advice that we've just heard over and over again is actually really, really good, right? So, sleep. Are we sleeping enough?Staying engaged with social relationships, that seems to be extremely important for longevity. And it's kind of amazing, actually. When they do these long-term studies on people who are thriving into old age, like they have really strong relationships. And that is so important.Moving our bodies and it does not need to be punishing. Workouts can be gardening. I know Virginia, I love receiving your gardening content online. Gardening is an amazing form of exercise, and can be very life affirming, and does not need to feel like punishment. Just getting up, moving our bodies, sleeping enough, maintaining relationships, cultivating a sense of purpose and meaning in our lives. It's actually been really studied right, that people who have a sense of meaning and have a sense of purpose in their lives tend to live longer and live longer, healthier lives.So all of this is to say that like it's complicated, but sometimes it's not. And there are a million people on the Internet who want to sell you a miracle drug, a miracle supplement, a miracle weighted vest, whatever. But sometimes simple, Simple is good. Easier said than done, right?VirginiaYeah, but start simple. That's wonderful.MaraCan I ask? Virginia, what would your advice be? VirginiaI love the three areas you hit on: Sleep, social relations and exercise or moving your body. None of those are about weight loss or dieting. I think that's really helpful for us to keep in mind that the things that might protect our health the most can also be very joyful as well. The idea that doing things that makes you happy and reduce your stress can be health-promoting is great. And I think that's something especially in midlife. We are all incredibly busy. We're holding a lot of things together. A lot of us are caregivers, maybe sandwich generation caregivers. So prioritizing your own joy in that feels really wonderful.ButterVirginiaAll right, so speaking of joy, let's do some Butter! Dr. Mara, what do you have forus?MaraI have a Philadelphia-specific one, but hopefully it can be extrapolated to our listeners in different locations. So I have recently been really craving soft serve ice cream. And so I googled best soft serve in Philadelphia, and I found this Vietnamese coffee shop called Càphê Roasters, which is in North Philly. In a neighborhood called Kensington. And it has condensed milk soft serve ice cream. So good.And so I recently, I had to give a lecture at a medical school in the north part of the city early in the morning. It was like, 8am and I was like, “Oh, I'm never up in this neighborhood. I gotta get over there.” And I went after I gave my lecture, and I bought myself ice cream at 10:30 in the morning. And I ate it in my car, and it was so good. Condensed milk. So good. But soft serve in general, is my Butter. But for those of you in Philly, go to Càphê Roasters in Kensington and get the condensed milk. It is chef's kiss, delicious.VirginiaAmazing. I'm gonna double your Butter and say ice cream in general is my Butter right now. We have a spare fridge freezer that I have just been loading up with all of the popsicles to get us through summer. But also: Ice cream dates. Something that comes up a lot for me as a co-parent is figuring out how to have one on one time with my kids. Since we have joint custody, they move as a package. So I get kid-free time, which is wonderful, but when they're with me, it's just me. So one thing I've been figuring out is pockets of time when I can take one kid out for ice cream. It's usually when a sibling is at another activity, and so we have an hour to kill, and often we would just like, wait for the activity, or go home and come back, and then you're just driving.And now I'm like, No, that will be our ice cream break!MaraI love that.VirginiaSo one kid's at the library doing her book trivia team stuff, and the other kid and I are getting ice cream while we wait for her. And it's great one on one time with kids. Obviously, the ice cream is delicious. The other thing I've realized, especially if you have younger kids who are still building restaurant skills, ice cream is a great practice run at being a person in a restaurant, which is really hard for kids understandably. It is one food thing that they're excited to go do. And you do have to sit and practice eating it somewhat neatly. There's a high mess potential. My pro-move for that is, always have wipes in your car, bring a pack of wipes in. MaraI love that, and it's so intentional about sort of creating traditions with kids. That feels really special. But I will say I had my ice cream solo, and that was also really good solo ice cream too.The Burnt Toast Podcast is produced and hosted by Virginia Sole-Smith (follow me on Instagram) and Corinne Fay, who runs @SellTradePlus, and Big Undies.The Burnt Toast logo is by Deanna Lowe.Our theme music is by Farideh.Tommy Harron is our audio engineer.Thanks for listening and for supporting anti-diet, body liberation journalism! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit virginiasolesmith.substack.com/subscribe

Dr. Dominic D'Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by: Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)Timestamps:[00:00:00] Start.[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.[00:18:18] A mechanisms overview for Alzheimer's/dementia.[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.[00:22:04] How to measure ketones and GKI.[00:23:00] Fasting vs. ketogenic diet.[00:24:18] There's nothing fishy about sardine fasting.[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.[00:31:57] Glucose tolerance testing revelations and CGM importance.[00:31:57] Upgrading the metabolic machinery through keto without getting bored.[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.[00:43:42] Dom's day-to-day diet regimen.[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.[00:51:30] Supplementing for sleep disruption while fasting.[00:55:41] Why Dom doesn't have misgivings about melatonin.[00:59:15] Shingles prevention through fasting protocols.[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.[01:03:54] Dom at 50-something: Current meal timing and composition.[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.[01:15:18] Ketone metabolic therapy for cancer.[01:18:15] The metabolic psychiatry revolution.[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.[01:28:27] Metformin vs. berberine.[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.*Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cold brew coffee may be smooth, trendy, and easy on the stomach — but is it secretly driving up your cholesterol? In today's episode, I'll break down the science behind cold brew, how it differs from hot coffee, and why, if you've had bariatric surgery or use GLP-1s, you should pay attention to this heart-health connection. Before you pour your next glass, listen in…Need resources to help with your bariatric lifestyle? Check out our Bariatric Tools page with meal plans, recipes, GLP-1 guide, etc.AD:Visit Procarenow.com now for all of your vitamin and mineral, calcium and protein needs. Use Code: BSS10 to save $Rate, Review & Follow on Apple Podcasts:"I love Dr. Susan and Bariatric Surgery Success." If this sounds like you, would you please rate and review my podcast? I love hearing from you, and it's actually super easy for you to leave a podcast rating. Wherever you listen to the Bariatric Surgery Success podcast, go to the review section and usually click a quick star rating. If you feel like taking it one small step further, please write a review if there's a place for one. Thank you!SummaryIn this episode, Dr. Susan Mitchell explores the health implications of cold brew coffee, particularly its effects on cholesterol levels. She discusses the differences between cold brew and traditional coffee and the importance of filtering coffee to manage cholesterol. The conversation emphasizes the need for awareness among bariatric surgery patients and those on GLP-1 medications regarding their coffee consumption and its potential health impacts.TakeawaysCold brew coffee may affect cholesterol levels differently than traditional coffee.Filtered coffee has minimal impact on cholesterol levels.Unfiltered coffee can increase LDL cholesterol due to diterpenes.Bariatric patients should consult their dietician before consuming caffeine post-surgery.Using a good filter can help reduce cholesterol-raising compounds in coffee.Cold brew is less acidic and may be easier on the stomach.Coffee contains bioactive compounds that can benefit heart health.Consider adding protein powder and cinnamon to cold brew for a nutritious drink.Chapters00:00Introduction to Cold Brew Coffee and Health Concerns02:46Understanding Cold Brew vs. Traditional Coffee05:05Cholesterol Levels and Coffee Brewing Methods07:55Healthy Coffee Alternatives and Recipes

Stephen Thomas interviews Dave Feldman about his recent study on near-lean mass hypersponders and the implications of high LDL cholesterol levels. They discuss the study's methodology, key findings, and address criticisms regarding the narrow participant range and the use of contrast dye in scans. The conversation also explores the relationship between LDL levels, health markers, and lifestyle factors that may contribute to plaque regression. Feldman emphasizes the importance of understanding the context of health markers and the need for further research in this area.Chapters00:00 Introduction to the Keto CTA Study06:55 Key Findings from the Study11:36 Critiques and Limitations of the Study16:01 The Role of Contrast Dye in Scans19:59 Understanding Regression in Plaque27:08 The LDL Dilemma and Metabolic Health37:51 Future Directions and Closing Thoughts

We hear a lot about LDL cholesterol as a contributor to heart disease, however there's an inherited cholesterol containing particle that also plays a factor. On this episode, we sit down with Dr. Hugh Coyne to learn more about Lipoprotein(a), or Lp(a), and how its presence affects our risk for cardiovascular disease.Dr. Hugh Coyne is a general practitioner and the co-founder of Coyne Medical in Parsons Green, London. Coyne Medical, has two state of the art Private Doctors Surgeries. They aim to lead the market in providing high quality accessible healthcare, using the latest technology and evidence to offer patients individualised holistic care.Episode Links:Learn more about Coyne MedicalFollow Dr. Hugh on social media: Instagram | LinkedInAbout Propel:Propel is the purpose-built well-being platform designed to help you develop a culture of well-being and bring your vision to life. Propel helps you launch a truly engaging program with flexible technology that tailors the experience to your diverse teams.Create a unique well-being experience from within. See how Propel can help by scheduling a free strategy session at propelwellbeing.com.

Dairy is often treated as a single food group, yet milk, yogurt, cheese, and butter can have very different effects on health. Some evidence links yogurt to favourable outcomes, while butter is known to raise LDL cholesterol. And then there's the paradox of cheese: high in saturated fat, but not consistently associated with higher heart disease risk. These complexities raise the question of whether the “dairy matrix” (the combination of nutrients and food structure) explains why not all dairy acts the same. In this episode, Prof. Jean-Philippe Drouin-Chartier, a nutrition researcher and registered dietitian, is on the show to examine what recent trials and large population studies tell us about dairy foods and cardiometabolic health. The discussion covers blood lipids, blood pressure, glucose metabolism, and how guidelines should interpret this evolving evidence. Timestamps [02:18] Interview start [09:38] Dairy consumption and type 2 diabetes [16:06] Dairy and cardiovascular disease [21:42] Dairy, blood pressure, and hypertension [25:56] Dietary guidelines and dairy [43:30] Key ideas segment (Premium-only) Related Resources Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Website: sigmanutrition.com Enroll in the next cohort of our Applied Nutrition Literacy course Referenced studies linked here  

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Suzanne: Thank you for your time in advance. In late 2021, my husband was diagnosed with Stage IV prostate cancer. He underwent six rounds of chemo along with Eligard injections. After his last scans, whole body and bone, we were told the cancer is "stabilized". He is currently on 300 mg of Nubeqa 2x a day (down from 4 x because I asked about it) and Lupron injections every 3 months. We have consciously changed our diet (no added sugar, no alcohol, no processed foods) and he is doing pretty well, although, he does fatigue and sweat easily. My question is whether you believe that taking a couple of your home tests would be beneficial for him? I worry about these powerful drugs he is being given and have noticed a reluctance from the doctor about reducing his drugs any further. Thank you again!                                                Sheena: Hi Dr C! Hope you and your team are well. I recently went for blood work. I fasted for 14 hours and was wondering what your thoughts are specifically regarding my Lipid Panel and Iron Panel. My triglycerides is 1.83, Total 4.05, HDL 1.72 and LDL 1.63 (all mmol/L). For iron my levels are 37 umol/L, iron binding 0.70 umol/L, and ferritin 44 ugL. My Dr says she's concerned with my triglycerides. How can I lower it? And shes concerned with my ferritin and iron levels so shes sending me for a Hemochromatosis blood test to see why the levels are off. (My fasting glucose is 4.9, hbA1c is 5.2, TSH is 1.04 and Auto CBC is 3.8). Would love your thoughts and any food and supplementation recommendations would be appreciated! Love you and all the best to everyone on their health journey!                                                            Madhia: Hello My Dr is giving me a hard time to prescribe MRI for my breast exam. Do you have any Dr you can recommend that would help me in greater Los Angeles area?                                                                                                 Margie: My son, who is 46 years old has had Alpha-Gal for approximately 10 years. Now his wife has also been diagnosed with it. I am aware it is caused by a tick bite. He constantly has mass cell inflammation including breathing and allergy issues. Could you please explain specifically how this disease affects the body's immune system and which of your protocols should be used to bring the body back into balance. Will that particular protocol bring the body back into balance enough so that it will relieve the mass cell inflammation and they can return to eating mammal meat?                                                     Jackie: Hi Dr. Cabral thank you for all that you do. You have made a tremendous impact in my and my clients lives. My husband has just finally been diagnosed after 10 years of misdiagnosis with neurogenic TOS. We have a great rehab team working on the biomechanics and we are exploring Big 5 root causes. I was wondering what natural pain management methods you would recommend during the process pain is 10/10 and conventional medicines wants to basically kill the nerve or put him on Lyrica which neither are an option for us. We are exploring accupuncture, grounding and adrenal sooth/inflammasoothe/cbd protocol. Any other alternative inflammation reduction techniques or devices you would recommend? Could you do a podcast on natural pain management strategies for people with chronic pain?          Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3495 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Bienvenidos a este podcast respondiendo vuestras dudas sobre edulcorantes, suplementos clave como la creatina y el omega-3, estrategias para reducir el colesterol LDL sin fármacos y cómo optimizar tu sueño de forma natural. También hablamos sobre testosterona, linfedema, lipedema y por qué el omeprazol puede ser un problema a largo plazo.Aqui el link de la CLASE GRATIS 60 MN: https://philhugo.com/clase-gratis-keto-ayuno/

Want a simple addition to your daily routine that can help lower cholesterol naturally?     On today's Cabral Concept, I'm sharing 5 science-backed drinks proven to lower your cholesterol.     I also share with you the exact amounts to consume shown in research to make a difference and how they can lower LDL cholesterol, improve blood pressure, reduce inflammation, and support overall heart health.     So join me on Cabral Concept 3485 to discover these 5 easy, research-supported drinks to help lower your cholesterol and how to work them into your routine for better cardiovascular wellness.     Enjoy the show, and let me know what you think!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3485 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

We have the second episode in a series of conversations with Dr. Thomas Dayspring today.  The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener.  You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners.  IN THIS EPISODE, YOU WILL LEARN: Why Lp(a) is like a wolf in sheep's clothing for many individuals How Lp(a) levels are higher in African Americans and women, especially after menopause  Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a) Why do women have a higher risk of dementia than men? Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport. How statins cross the blood-brain barrier to lower brain cholesterol Why desmosterol levels matter New therapies that can lower ApoB and Lp(a) Why imaging is essential for menopausal women with elevated ApoB and Lp(a) Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Thomas Dayspring On X (@Drlipid) On LinkedIn Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations  Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?

This week, Dr. Joel Kahn reviews the latest research on men's health, focusing on diet and prostate cancer. He highlights findings that support whole-food, plant-based diets and discusses the connection between prostate cancer, heart disease, and the cardiovascular risks associated with androgen deprivation therapy (ADT). Other topics covered include plant-based diets and disease rates, the role of LDL cholesterol in soft plaque formation, TMAO in abdominal aortic aneurysms and kidney disease, periodontal disease and its impact on heart health, saccharin and cardiovascular risk, extreme physical activity and carotid plaque, and the effects of Tylenol use during pregnancy.  Dr. Kahn also reviews new research on cyclodextrin suppositories, a paper examining the impact of statins on blood sugar, and the potential role of TUDCA as a possible antidote.  Resources mentioned in this episode include the cyclodextrin paper available at www.atherocare.com/drjoelkahn and details on TUDCA at https://shop.drjoelkahn.com/catalog/product/view/id/17560/s/tudca-tauroursodeoxycholic-acid-60-capsules/. Special thanks to our sponsor Igennus.com, use discount code DrKahn for all products.

In this eye-opening conversation, Dr. Ford Brewer—renowned preventive medicine specialist and founder of the Brewer Clinic—joins Dr. Robert Kiltz to unpack the silent epidemic of metabolic disease and why most Americans are unknowingly living with it. From his early disillusionment with traditional medicine to his mission to empower patients through education, Dr. Brewer shares decades of insight on how lifestyle—not prescriptions—is the real cure.

Send us a textWide release date: August 25, 2025Episode Summary: Dr. Uffe Ravnskov talks about his decades-long career challenging the idea that high cholesterol causes heart disease, discussing LDL's protective role in the immune system by binding to bacteria, the harms and biases in statin research influenced by pharmaceutical companies, evidence that high cholesterol benefits the elderly and reduces infection/cancer risks, and how mental stress or infections elevate cholesterol as a response rather than a cause.About the guest: Uffe Ravnskov, MD, PhD is a physician and independent researcher who earned his MD from the University of Copenhagen in 1961 and a PhD in nephrology. He has worked in various clinics in Sweden since the 1960s, focusing his research on challenging the cholesterol hypothesis in heart disease. Now 91, he has published over 200 papers, authored books like "The Cholesterol Myths.”Discussion Points:LDL cholesterol helps the immune system by sticking to bacteria, clumping them for removal; low LDL increases infection risk.Animal studies show injecting LDL protects against lethal infections, while historical data links severe infections to worse atherosclerosis.Elderly people with high cholesterol live longer; low cholesterol raises mortality risk more than high levels.Familial hypercholesterolemia (FH) doesn't cause early death via cholesterol alone—co-inherited coagulation factors are the issue, and FH patients often have lower infection rates.Statins lower LDL but increase infection risk, cause muscle weakness/brain issues (often blamed on aging), and show no clear benefit in unbiased meta-analyses.Research biases include cherry-picking studies, exaggerating benefits via relative (not absolute) risk, and pharma funding suppressing critical views.Mental stress can raise cholesterol by 10-50% in 30 minutes, often misread as a heart disease cause rather than an effect.Saturated fat and high cholesterol aren't proven harmful; Ancel Keys' claims ignored contradictory evidence.Stopping statins often reverses side effects quickly, improving quality of life.Related episode:M&M 244: Seed Oils & Heart Disease: Oxidized LDL, Cholesterol, Fat & Cardiology | Tucker GoodrichReference Paper:LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Join Dr. Philip Ovadia and Practice Manager Cherish Thompson for a compelling conversation on cardiovascular disease (CVD) and the path to restoring health and quality of life. They'll explore the importance of early diagnostics, working with a cardiothoracic surgeon, and addressing key factors like metabolic health, LDL cholesterol, and lifestyle changes. Gain valuable insights into tackling heart disease and making impactful changes to achieve long-term wellness.Send Dr. Ovadia a Text Message. (If you want a response, you must include your contact information.) Dr. Ovadia cannot respond here. To contact his team, please send an email to team@ifixhearts.com Like what you hear? Head over to IFixHearts.com/book to grab a copy of my book, Stay Off My Operating Table. Ready to go deeper? Talk to someone from my team at IFixHearts.com/talk.Stay Off My Operating Table on X: Dr. Ovadia: @iFixHearts Jack Heald: @JackHeald5 Learn more: Stay Off My Operating Table on Amazon Take Dr. Ovadia's metabolic health quiz: iFixHearts Dr. Ovadia's website: Ovadia Heart Health Jack Heald's website: CultYourBrand.com Theme Song : Rage AgainstWritten & Performed by Logan Gritton & Colin Gailey(c) 2016 Mercury Retro RecordingsAny use of this intellectual property for text and data mining or computational analysis including as training material for artificial intelligence systems is strictly prohibited without express written consent from Dr. Philip Ovadia.

Want a simple addition to your daily routine that can help lower cholesterol naturally?     On today's Cabral Concept, I'm sharing 5 science-backed drinks proven to lower your cholesterol.      I also share with you the exact amounts to consume shown in research to make a difference and how they can lower LDL cholesterol, improve blood pressure, reduce inflammation, and support overall heart health.     So join me on Cabral Concept 3485 to discover these 5 easy, research-supported drinks to help lower your cholesterol and how to work them into your routine for better cardiovascular wellness.     Enjoy the show, and let me know what you think!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3485 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Lionel's talks about his unique fascinations, ranging from the foot skills of soccer to the behaviors of people in society, and his candid disinterest in organized sports fandom. Lionel talks to 90-year-old Chuck, a retired journeyman electrician, who shares life wisdom, discusses the Cold War's DEW line, and reveals his recent adoption of Wi-Fi. Lionel also talks about modern medical insights into heart disease, the critical role of LDL cholesterol, and a critique of popular diet fads such as the Atkins and carnivore diets. Learn more about your ad choices. Visit megaphone.fm/adchoices

We've been told to run, bike, and diet our way to lower cholesterol, but what if the real game changer is strength training? In this episode, Amy Hudson and Dr. James Fisher unpack the science behind resistance training and why it might be the best exercise to lower cholesterol. They explore what research actually says about lifting weights, LDL reduction, and long-term heart health — and why it might be time to rethink your approach to fitness. Dr. Fisher defines cholesterol--a waxy, hormone-like substance that your body produces and regulates on its own. While it often gets labeled as “bad,” it plays vital roles in hormone production and cell health. Dr. Fisher highlights that what we call “cholesterol” is actually carried in the blood by lipoproteins. LDL (low-density lipoproteins) can clog arteries, while HDL (high-density lipoproteins) helps remove excess cholesterol from the bloodstream. Amy breaks down how LDL is considered the “bad” cholesterol because it can harden and narrow artery walls. In contrast, HDL acts like a cleanup crew, carrying unused cholesterol back to the liver to be broken down or reused. Dr. Fisher discusses a meta-analysis of 69 studies involving over 2,000 people that showed consistent benefits from strength training. Participants saw reductions in total cholesterol, LDL, and triglycerides, along with increases in HDL and adiponectin levels. Amy points out that participants who strength trained saw an average drop in total cholesterol of about 8.5 mg/dL. That's a significant improvement — and it didn't require any changes to diet. Dr. Fisher emphasizes that these changes happened independently of calorie restriction or food tracking. Amy and Dr. Fisher explain that the cholesterol-lowering effects of strength training were consistent, whether people trained once, twice, or three times a week. Frequency mattered less than simply doing the work. Dr. Fisher breaks down one individual study in the meta-analysis that used six months of full-body strength training. The results showed reduced fat mass, decreased LDL, and increased HDL — all strong markers of better metabolic health. The cholesterol improvements were not just a side effect of losing weight or fat. The act of strength training alone led to these changes, regardless of body composition. Amy challenges the common belief that cholesterol is only affected by food or medication. The data shows strength training is a powerful, underused tool to shift your numbers naturally. Learn how strength training offers more than just physical benefits — it's also a stress reliever. Pushing through a high-effort workout helps unload mental baggage, too. Amy and Dr. Fisher explore how dietary choices still matter — and discuss how eggs, red meat, and even wine influence cholesterol levels. They encourage variety and moderation over strict elimination. Dr. Fisher advises people to “eat the rainbow,” meaning to include colorful, nutrient-dense foods in your diet. He cautions that many Western diets are too dominated by fried and processed foods — and lack the diversity our bodies need. Amy and Dr. Fisher conclude that combining smart dietary choices with consistent strength training may be one of the most effective ways to lower cholesterol naturally.     Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com Previous episode - Why Most People Fail in the Gym (And How Supervision With a Personal Trainer Can Help)     This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.

About the Guest(s): Dr. Kristin Hieshetter is a renowned expert in nutrition, health, and wellness, known for her insights into the impact of dietary choices on overall health. With a focus on the effects of non-nutritive sweeteners, gut health, and oxidative stress on the body, Dr. Hieshetter is a leading voice in helping individuals understand how modern dietary elements affect their well-being. She is a frequent speaker and educator in the field, dedicated to making scientific research accessible to the public. Episode Summary: In this enlightening episode, Dr. Kristin Hieshetter delves into the intricate world of non-nutritive sweeteners, focusing on erythritol and its alarming implications for brain health and cardiovascular risk. Drawing from a forthcoming 2025 study, she discusses the adverse effects of erythritol on brain microvascular endothelial function, highlighting increased risks for cerebrovascular events and cardiovascular mortality. Extend the conversation to include a large cohort study involving Finnish smokers, Dr. Hieshetter emphasizes the dire consequences associated with erythritol consumption, urging a reevaluation of these sweeteners' legality given their potential health risks. Dr. Hieshetter further explores the complexities of sweeteners like stevia and their unknown long-term impacts. She references various studies, including Project SWEET and insights from European research on artificial sweeteners, revealing how these substances may inadvertently contribute to chronic health issues like elevated triglycerides and impaired kidney function. Shifting attention to gut health, Dr. Hieshetter emphasizes dietary integrity and the pivotal role of a healthy gut microbiome in preventing inflammation and chronic disease. Concluding with practical dietary advice and upcoming topics on gut health, Dr. Hieshetter leaves listeners equipped with crucial knowledge and a call for proactive health vigilance. Key Takeaways: Erythritol, a common non-nutritive sweetener, has been linked to increased risks of cardiovascular and cerebrovascular diseases in a recent study. The Finnish cohort study uncovers grave mortality risks tied to erythritol, with significant implications for cancer and heart disease. Despite its popularity, the long-term safety of stevia remains largely unvalidated, with some evidence suggesting potential health risks. Gut health plays a critical role in overall wellness, and maintaining a balanced microbiome is crucial in preventing kidney and other systemic health issues. Dr. Hieshetter advocates for choosing natural foods over artificial additives to reduce health hazards related to modern dietary patterns. Notable Quotes: "Erythritol is actually changing the microvascular function of the blood vessels that bring nutrients to the brain." "The higher the erythritol, the higher the risk of death and cancer in these folks." "Ingesting all these artificial sweeteners either raised your triglycerides and your liver enzymes or raised your LDL cholesterol." "It's really critical to understand that when you see these groups… they can be manufactured without the things that are harmful to our brains." "Gut permeability is pivotal in the etiology of all immune disorders and in eliciting chronic inflammation." Resources: Moms Across America: An organization focused on protecting children from harmful food additives and advocating for safer food production practices. World Health Organization: Provides guidelines on sweetener use and health recommendations. Project SWEET Study: A study evaluating the effects of non-nutritive sweeteners on metabolism and health. Gut Microbiome Research: Studies exploring the link between gut health and systemic disease prevention. Join and listen to the full episode for an in-depth understanding of how today's dietary choices impact health, with crucial insights from Dr. Kristin Hieshetter. Stay tuned for more episodes that delve into health, wellness, and nutritional science!

This is a hybrid heart disease risk factor post of a podcast with Prof Bruce Lanphear on lead and a piece I was asked to write for the Washington Post on risk factors for heart disease.First, the podcast. You may have thought the problem with lead exposure was circumscribed to children, but it's a much bigger issue than that. I'll concentrate on the exposure risk to adults in this interview, including the lead-estrogen hypothesis. Bruce has been working on the subject of lead exposure for more than 30 years. Let me emphasize that the problem is not going away, as highlighted in a recent New England Journal of Medicine piece on lead contamination in Milwaukee schools, “The Latest Episode in an Ongoing Toxic Pandemic.”Transcript with links to the audio and citationsEric Topol (00:05):Well, hello. This is Eric Topol with Ground Truths, and I'm very delighted to welcome Professor Bruce Lanphear from Simon Fraser University in British Columbia for a very interesting topic, and that's about lead exposure. We tend to think about lead poisoning with the Flint, Michigan, but there's a lot more to this story. So welcome, Bruce.Bruce Lanphear (00:32):Thank you, Eric. It's great to be here.Eric Topol (00:33):Yeah. So you had a New England Journal of Medicine (NEJM) Review in October last year, which was probably a wake up to me, and I'm sure to many others. We'll link to that, where you reviewed the whole topic, the title is called Lead Poisoning. But of course it's not just about a big dose, but rather chronic exposure. So maybe you could give us a bit of an overview of that review that you wrote for NEJM.Bruce Lanphear (01:05):Yeah, so we really focused on the things where we feel like there's a definitive link. Things like lead and diminished IQ in children, lead and coronary heart disease, lead and chronic renal disease. As you mentioned, we've typically thought of lead as sort of the overt lead poisoning where somebody becomes acutely ill. But over the past century what we've learned is that lead is one of those toxic chemicals where it's the chronic wear and tear on our bodies that catches up and it's at the root of many of these chronic diseases that are causing problems today.Eric Topol (01:43):Yeah, it's pretty striking. The one that grabbed me and kind of almost fell out of my chair was that in 2019 when I guess the most recent data there is 5.5 million cardiovascular deaths ascribed to relatively low levels, or I guess there is no safe level of lead exposure, that's really striking. That's a lot of people dying from something that cardiology and medical community is not really aware of. And there's a figure 3 [BELOW] that we will also show in the transcript, where you show the level where you start to see a takeoff. It starts very low and by 50 μg/liter, you're seeing a twofold risk and there's no threshold, it keeps going up. How many of us do you think are exposed to that type of level as adults, Bruce?Bruce Lanphear (02:39):Well, as adults, if we go back in time, all of us. If you go back to the 1970s when lead was still in gasoline, the median blood lead level of Americans was about 13 to 15 µg/dL. So we've all been exposed historically to those levels, and part of the reason we've begun to see a striking decline in coronary heart disease, which peaked in 1968. And by 1978, there was a 20% decline, 190,000 more people were alive than expected. So even in that first decade, there was this striking decline in coronary heart disease. And so, in addition to the prospective studies that have found this link between an increase in lead exposure and death from cardiovascular disease and more specifically coronary heart disease. We can look back in time and see how the decline in leaded gasoline led to a decline in heart disease and hypertension.Eric Topol (03:41):Yeah, but it looks like it's still a problem. And you have a phenomenal graph that's encouraging, where you see this 95% reduction in the lead exposure from the 1970s. And as you said, the factors that can be ascribed to like getting rid of lead from gasoline and others. But what is troubling is that we still have a lot of people that this could be a problem. Now, one of the things that was fascinating is that you get into that herbal supplements could be a risk factor. That we don't do screening, of course, should we do screening? And there's certain people that particularly that you consider at high risk that should get screened. So I wasn't aware, I mean the one type of supplements that you zoomed in on, how do you say it? Ayurvedic?Supplements With LeadBruce Lanphear (04:39):Oh yeah. So this is Ayurvedic medicine and in fact, I just was on a Zoom call three weeks ago with a husband and wife who live in India. The young woman had taken Ayurvedic medicine and because of that, her blood lead levels increased to 70 µg/dL, and several months later she was pregnant, and she was trying to figure out what to do with this. Ayurvedic medicine is not well regulated. And so, that's one of the most important sources when we think about India, for example. And I think you pointed out a really important thing is number one, we don't know that there's any safe level even though blood lead levels in the United States and Europe, for example, have come down by over 95%. The levels that we're exposed to and especially the levels in our bones are 10 to 100 times higher than our pre-industrial ancestors.Bruce Lanphear (05:36):So we haven't yet reached those levels that our ancestors were exposed to. Are there effects at even lower and lower levels? Everything would suggest, we should assume that there is, but we don't know down below, let's say one microgram per deciliter or that's the equivalent of 10 parts per billion of lead and blood. What we also know though is when leaded gasoline was restricted in the United States and Canada and elsewhere, the companies turned to the industrializing countries and started to market it there. And so, we saw first the epidemic of coronary heart disease in the United States, Canada, Europe. Then that's come down over the past 50 years. At the same time, it was rising in low to middle income countries. So today over 95% of the burden of disease from lead including heart disease is found in industrializing countries.Eric Topol (06:34):Right. Now, it's pretty striking, of course. Is it true that airlines fuel is still with lead today?Bruce Lanphear (06:45):Well, not commercial airlines. It's going to be a small single piston aircraft. So for example, when we did a study down around the Santa Clara County Airport, Reid-Hillview, and we can see that the children who live within a half mile of the airport had blood lead levels about 10% higher than children that live further away. And the children who live downwind, 25% higher still. Now, nobody's mapped out the health effects, but one of the things that's particularly troubling about emissions from small aircraft is that the particle size of lead is extraordinarily small, and we know how nanoparticles because they have larger surface area can be more problematic. They also can probably go straight up into the brain or across the pulmonary tissues, and so those small particles we should be particularly worried about. But it's been such a long journey to try to figure out how to get that out of aircraft. It's a problem. The EPA recognized it. They said it's an endangerment, but the industry is still pushing back.Eric Topol (07:55):Yeah, I mean, it's interesting that we still have these problems, and I am going to in a minute ask you what we can do to just eradicate lead as much as possible, but we're not there yet. But one study that seemed to be hard to believe that you cited in the review. A year after a ban leaded fuel in NASCAR races, mortality from coronary heart disease declined significantly in communities near racetracks. Can you talk about that one because it's a little bit like the one you just mentioned with the airports?Bruce Lanphear (08:30):Yeah. Now that study particularly, this was by Alex Hollingsworth, was particularly looking at people over 65. And we're working on a follow-up study that will look at people below 65, but it was quite striking. When NASCAR took lead out of their fuel, he compared the rates of coronary heart disease of people that live nearby compared to a control group populations that live further away. And he did see a pretty striking reduction. One of the things we also want to look at in our follow-up is how quickly does that risk begin to taper off? That's going to be really important in terms of trying to develop a strategy around preventing lead poisoning. How quickly do we expect to see it fall? I think it's probably going to be within 12 to 24 months that we'll see benefits.Eric Topol (09:20):That's interesting because as you show in a really nice graphic in adults, which are the people who would be listening to this podcast. Of course, they ought to be concerned too about children and all and reproductive health. But the point about the skeleton, 95% of the lead is there and the main organs, which we haven't mentioned the kidney and the kidney injury that occurs no less the cardiovascular, the blood pressure elevation. So these are really, and you mentioned not necessarily highlighted in that graphic, but potential cognitive hit as well. You also wrote about how people who have symptoms of abdominal pain, memory impairment, and high blood pressure that's unexplained, maybe they should get a blood level screening. I assume those are easy to get, right?Bruce Lanphear (10:17):Oh yeah, absolutely. You can get those in any hospital, any clinic across the country. We're still struggling with having those available where it's most needed in the industrializing countries, but certainly available here. Now, we don't expect that for most people who have those symptoms, lead poisoning is going to be the cause, right. It'd still be unusual unless you work in an industry, for example, smelting batteries to recycle them. We don't expect it to be real common, and we're not even sure, Eric, whether we should be doing widespread screening. If I looked at this as a population scientist, the real focus should be on identifying the sources. We mostly know where those are here and radically moving it down. Getting rid of the lead service lines, which was such a big part of what President Biden was doing, and it was perfect. For every dollar invested to reduce lead exposure from those lead service lines. Ronnie Levin at Harvard said there'd be a 35-fold return in cost, benefits really, and this has always been true, that reducing lead exposure throughout the past 40 years has always been shown to be amazingly cost beneficial. The problem is operating within a free market health system, even though there's tremendous social benefits, that benefit isn't going to be monetized or privatized. And so, who's going to make those decisions? We hope our government is, but that doesn't always play out.Eric Topol (11:52):Well. What's interesting is, as opposed to the problems we have today that are prominent such as the microplastic, nanoplastics, the air pollution, the forever chemicals, that just keep getting worse, I mean, they are just cumulative. This one, there was tremendous improvement, but it's still not enough. And I guess you're zooming in on the lead lines. That'd be the most important thing to work on today. Another thing that has come up, there's been trials, as you may I'm sure, because all over this field of chelation, there's a trial that was run by the NIH, supported by NH that looked at chelation to prevent coronary disease. Is there any evidence that people who have a problem with lead would benefit from chelation therapy?Bruce Lanphear (12:44):Well, there's two major studies that have been done, and Tony Lamas was in charge of both of them. The first one Trial to Assess Chelation Therapy (TACT) study, it was a randomized controlled trial, not intended specifically to focus on lead, but rather it was to look at sort of this alternative therapy. They found significant benefits about an 18% reduction in subsequent cardiac events. That led to a second study that was just published last year, and it was focused on people who had diabetes. They saw some benefit, but it wasn't significant. So whether that's because there wasn't enough variability and exposure, it's not entirely clear, but we've seen this with lead in IQ deficits in kids where we can show that we can reduce blood lead levels. But ultimately what tends to happen is once you've taken lead out of the blood, some of it's released again from the bone, but you still have all that lead in the bone that's there. You get some of it out, but you're not going to get the bulk of it out.The Lead-Estrogen HypothesisEric Topol (13:47):Right. It's a reservoir that's hard to reckon with. Yeah. Now another thing, you have a Substack that is called Plagues, Pollution & Poverty, and you wrote a really provocative piece in that earlier and April called How Estrogen Keeps Lead - and Heart Attacks - in Check, and basically you got into the lead estrogen hypothesis.Eric Topol (14:10):Can you enlighten us about that?Bruce Lanphear (14:12):Yeah. A lot of the seminal work in this area was done by Ellen Silbergeld, who's a brilliant and somewhat peculiar toxicologist and Ellen for years, I focused on childhood lead exposure, and for years Ellen would tell me, almost demolish me for not studying adults. And because she had found back in 1988 that as women go into menopause, their blood lead levels spike increased by about 30%, and that's where most of our lead is stored is in our bone. And so, as I was thinking about this, it all became clear because blood lead levels in boys and girls is about the same. It's comparable up until menarche, and then girls young women's blood leads fall by about 20%. And they stay 20% lower throughout the reproductive years until menopause. And especially during those first few years around menopause, perimenopause, you see fairly striking increases in the weakening of the bone and blood lead levels.Bruce Lanphear (15:19):So that might very well help to explain why estrogen is protected, because what happens is throughout the reproductive life, women are losing a little bit of lead every month. And estrogen is at its lowest during that time, and that's going to be when blood lead is at its highest because estrogen pushes lead into the bone. Not only that, women lose lead into the developing fetus when they're pregnant. So what Ellen found is that there was less of a spike around menopause for the women that had three or four pregnancies because they had offloaded that into their babies. So all of this, if you put it together, and this is of course in a very short note of it, you can see that lead increases dyslipidemia, it leads to tears in the endothelium of the arterial wall, it's going to increase thrombosis. All of these things that we think of as the classic atherosclerosis. Well, what estrogen does is the opposite of those. It decreases dyslipidemia, it repairs the arterial endothelial wall. So how much of it is that estrogen is protective, and how much is it that it's moving lead out of the system, making it less biologically available?Eric Topol (16:46):Yeah, I know. It's really interesting. Quite provocative. Should be followed up on, for sure. Just getting to you, you're a physician and epidemiologist, MD MPH, and you have spent your career on this sort of thing, right? I mean, is your middle name lead or what do you work on all the time?Bruce Lanphear (17:09):Yeah, I've been doing this for about 30 years, and one of my mentors, Herb Needleman spent 40 years of his career on it. And in some ways, Eric, it seems to me particularly in these very difficult entrenched problems like lead, we don't have any pharmaceutical company reaching out to us to promote what we do. We've got industry trying to squash what we do.Bruce Lanphear (17:35):It really does take a career to really make a dent in this stuff. And in a way, you can look at my trajectory and it is really following up on what Herb Needleman did and what Clare Patterson did, and that was finding the effects at lower and lower levels. Because what we do with lead and most other toxic chemicals, the ones that don't cause cancer, is we assume that there's a safe level or threshold until we prove otherwise. And yet when you look at the evidence, whether it's about asbestos and mesothelioma, air pollution and cardiovascular mortality, lead and cardiovascular mortality, benzene and leukemia, none of those exhibit a threshold. In some cases, the risks are steepest proportionately at the lowest measurable levels, and that really raises some tremendous challenges, right? Because how are we going to bring air pollution or lead down to zero? But at the same time, it also provides these tremendous opportunities because we know that they're causing disease. We know what the sources are. If we could only bring about the political will to address them, we could prevent a lot of death, disease, and disability. I mean, about 20% of deaths around the world every year are from air pollution, lead, and other toxic chemicals, and yet the amount of money we invest in them is just paltry compared to what we invest in other things. Which is not to pit one against the other, but it's to say we haven't invested enough in these.Eric Topol (19:14):No, absolutely. I think your point, just to make sure that it's clear, is that even at low levels, this is of course where most of the population exposure would be, and that's why that's so incriminating. Now, one of the things I just want to end up with is that we know that these are tiny, tiny particles of lead, and then the question is how they can synergize and find particulate matter of air pollution in the nanoplastic, microplastic story and binding to forever chemicals, PFAS. How do you process all that? Because it's not just a single hit here, it's also the fact that there's ability to have binding to the other environmental toxins that are not going away.Bruce Lanphear (20:10):That's right. And in a way, when we talk about lead playing this tremendous role in the rise and decline of coronary heart disease, we can't entirely separate it out, for example, from air pollution or cigarette smoke for that matter, nor plastic. So for example, with air pollution, if we look at air pollution over the past century, up until the 1980s, even into the 1990s, it was leaded, right? So you couldn't separate them. If you look at cigarette smoke, cigarette tobacco in the 1940s and 1950s was grown in fields where they used lead arsenic as an insecticide. So smokers even today have blood lead levels that are 20% higher than non-smokers, and people who are not smokers but exposed to secondhand smoke have blood lead levels 20% higher than non-smokers who aren't exposed to secondhand smoke. So in a way, we should try to tease apart these differences, but it's going to be really challenging. In a way we can almost think about them as a spectrum of exposures. Now with plastics, you can really think of plastics as a form of pollution because it's not just one thing. There's all these additives, whether it's the PFAS chemicals or lead, which is used as a stabilizer. And so, all of them really are kind of integrated into each other, which again, maybe there's some opportunity there if we really were ready to tackle.Eric Topol (21:40):And interestingly, just yesterday, it was announced by the current administration that they're stopping all the prior efforts on the forever chemicals that were initiated in the water supply. And I mean, if there's one takeaway from our discussion, it's that we have to get all over this and we're not paying enough attention to our environmental exposures. You've really highlighted spotlighted the lead story. And obviously there are others that are, instead of getting somewhat better, they're actually going in the opposite direction. And they're all tied together that's what is so striking here, and they all do many bad things to our bodies. So I don't know how, I'm obviously really interested in promoting healthy aging, and unless we get on this, we're chasing our tails, right?Bruce Lanphear (22:31):Well, I think that's right, Eric. And I was reading the tips that you'd written about in preparation for your book release, and you focused understandably on what each of us can do, how we can modify our own lifestyles. We almost need six tips about what our government should do in order to make it harder for us to become sick, or to encourage those healthy behaviors that you talked about. That's a big part of it as well. One of the things we're celebrating the hundredth anniversary. This is not really something to celebrate, but we are. The hundredth anniversary of the addition of tetraethyl lead to gasoline. And one of the key things about that addition, there was this debate because when it was being manufactured, 80% of the workers at a plant in New Jersey suffered from severe lead poisoning, and five died, and it was enough that New York City, Philadelphia and New Jersey banned tetraethyl lead.Bruce Lanphear (23:31):Then there was this convening by the US Surgeon General to determine whether it was safe to add tetraethyl lead to gasoline. One scientist, Yandell Henderson said, absolutely not. You're going to create a scourge worse than tuberculosis with slow lead poisoning and hardening of your arteries. Robert Kehoe, who represented the industry said, we know lead is toxic, but until you've shown that it's toxic when added to gasoline, you have no right to prohibit us from using it. So that is now known as the Kehoe rule, and it's relevant not only for lead, but for PFAS, for air pollution, for all these other things, because what it set as a precedent, until you've shown that these chemicals or pollution is toxic when used in commerce, you have no right to prohibit industry from using it. And that's the fix we're in.Eric Topol (24:27):Well, it sounds too much like the tobacco story and so many other things that were missed opportunities to promote public health. Now, is Canada doing any better than us on this stuff?Bruce Lanphear (24:40):In some ways, but not in others. And one of the interesting thing is we don't have standards, we have guidelines. And amazingly, the cities generally try to conform to those guidance levels. With water lead, we're down to five parts per billion. The US is sticking around with ten parts per billion, but it's not even really very, it's not enforced very well. So we are doing better in some ways, not so good in other ways. The European Union, generally speaking, is doing much better than North America.Eric Topol (25:15):Yeah, well, it doesn't look very encouraging at the moment, but hopefully someday we'll get there. Bruce, this has been a really fascinating discussion. I think we all should be thankful to you for dedicating your career to a topic that a lot of us are not up on, and you hopefully are getting us all into a state of awareness. And congratulations on that review, which was masterful and keep up the great work. Thank you.Bruce Lanphear (25:42):Thank you, Eric. I appreciate it.________________________________________________My Recommendations for Preventing Heart Disease (Markedly Truncated from Text and Graphics Provided in SUPER AGERS)Recently the Washington Post asked me for a listicle of 10 ways to prevent heart disease. I generally avoid making such lists but many people have de-subscribed to this newspaper, never subscribed, or missed the post, so here it is with links to citations:Guest column by Eric Topol, MDThe buildup of cholesterol and other substances in the wall of our arteries, known as atherosclerosis, is common. It can lead to severe plaques that narrow the artery and limit blood flow, or to a crack in the artery wall that can trigger blood clot formation, resulting in a heart attack.While we've seen some major advances in treating heart disease, it remains the leading killer in the United States, even though about 80 percent of cases are considered preventable. There are evidence-based steps you can take to stave it off. As a cardiologist, here's what I recommend to my patients.1. Do both aerobic and resistance exerciseThis is considered the single most effective medical intervention to protect against atherosclerosis and promote healthy aging. Physical activity lowers inflammation in the body. Evidence has shown that both aerobic and strength training forms of exercise are important. But only 1 in 4 Americans meet the two activity guidelines from the American Heart Association: aerobic exercise of 150 minutes per week of at least moderate physical activity, such as walking, bicycling on level ground, dancing or gardening, and strength training for at least two sessions per week, which typically translates to 60 minutes weekly.The protective benefit of exercise is seen with even relatively low levels of activity, such as around 2,500 steps per day (via sustained physical activity, not starting and stopping), and generally increases proportionately with more activity. It used to be thought that people who exercise only on the weekend — known as “weekend warriors” — put themselves in danger, but recent data shows the benefits of exercise can be derived from weekend-only workouts, too.2. Follow an anti-inflammatory dietA predominantly plant-based diet — high in fiber and rich in vegetables, fruits and whole grains, as seen with the Mediterranean diet — has considerable evidence from large-scale observational and randomized trials for reducing body-wide inflammation and improving cardiovascular outcomes.Foods rich in omega-3 fatty acids, such as salmon, also form part of a diet that suppresses inflammation. On the other hand, red meat and ultra-processed foods are pro-inflammatory, and you should limit your consumption. High protein intake of more than 1.4 grams per kilogram of body weight per day — around 95 grams for someone who is 150 pounds — has also been linked to promoting inflammation and to atherosclerosis in experimental models. That is particularly related to animal-based proteins and the role of leucine, an essential amino acid that is obtained only by diet.3. Maintain a healthy weightBeing overweight or obese indicates an excess of white adipose tissue. This kind of tissue can increase the risk of heart disease because it stores fat cells, known as adipocytes, which release substances that contribute to inflammation.In studies, we've seen that glucagon-like peptide (GLP-1) drugs can reduce inflammation with weight loss, and a significant reduction of heart attacks and strokes among high-risk patients treated for obesity. Lean body weight also helps protect against atrial fibrillation, the most common heart rhythm abnormality.4. Know and avoid metabolic syndrome and prediabetesTied into obesity, in part, is the problem of insulin resistance and metabolic syndrome. Two out of three people with obesity have this syndrome, which is defined as having three out of five features: high fasting blood glucose, high fasting triglycerides, high blood pressure, low high-density lipoprotein (HDL) and central adiposity (waist circumference of more than 40 inches in men, 35 inches in women).Metabolic syndrome is also present in a high proportion of people without obesity, about 50 million Americans. Prediabetes often overlaps with it. Prediabetes is defined as a hemoglobin A1c (a measure of how much glucose is stuck to your red blood cells) between 5.7 and 6.4 percent, or a fasting glucose between 100 and 125 milligrams per deciliter.Both metabolic syndrome and prediabetes carry an increased risk of heart disease and can be prevented — and countered — by weight loss, exercise and an optimal diet.As the glucagon-like peptide drug family moves to pills and less expense in the future, these medications may prove helpful for reducing risk in people with metabolic syndrome and prediabetes. For those with Type 2 diabetes, the goal is optimizing glucose management and maximal attention to lifestyle factors.5. Keep your blood pressure in a healthy rangeHypertension is an important risk factor for heart disease and is exceptionally common as we age. The optimal blood pressure is 120/80 mm Hg or lower. But with aging, there is often an elevation of systolic blood pressure to about 130 mm Hg, related to stiffening of arteries. While common, it is still considered elevated.Ideally, everyone should monitor their blood pressure with a home device to make sure they haven't developed hypertension. A mild abnormality of blood pressure will typically improve with lifestyle changes, but more substantial elevations will probably require medications.6. Find out your genetic riskWe now have the means of determining your genetic risk of coronary artery disease with what is known as a polygenic risk score, derived from a gene chip. The term polygenic refers to hundreds of DNA variants in the genome that are linked to risk of heart disease. This is very different from a family history, because we're a product of both our mother's and father's genomes, and the way the DNA variants come together in each of us can vary considerably for combinations of variants.That means you could have high or low risk for heart disease that is different from your familial pattern. People with a high polygenic risk score benefit the most from medications to lower cholesterol, such as statins. A polygenic risk score can be obtained from a number of commercial companies, though it isn't typically covered by insurance.I don't recommend getting a calcium score of your coronary arteries via a computed tomography (CT) scan. This test is overused and often induces overwhelming anxiety in patients with a high calcium score but without symptoms or bona fide risk. If you have symptoms suggestive of coronary artery disease, such as chest discomfort with exercise, then a CT angiogram may be helpful to map the coronary arteries. It is much more informative than a calcium score.7. Check your blood lipidsThe main lipid abnormality that requires attention is low-density cholesterol (LDL), which is often high and for people with increased risk of heart disease should certainly be addressed. While lifestyle improvements can help, significant elevation typically requires medications such as a statin; ezetimibe; bempedoic acid; or injectables such as evolocumab (Repatha), alirocumab (Praluent) or inclisiran (Leqvio). The higher the risk, the more aggressive LDL lowering may be considered.It should be noted that the use of potent statins, such as rosuvastatin or atorvastatin, especially at high doses, is linked to inducing glucose intolerance and risk of Type 2 diabetes. While this is not a common side effect, it requires attention since it is often missed from lack of awareness.A low high-density lipoprotein (HDL) cholesterol often responds to weight loss and exercise. We used to think that high HDL was indicative of “good cholesterol,” but more recent evidence suggests that is not the case and it may reflect increased risk when very high.To get a comprehensive assessment of risk via your blood lipids, it's important to get the apolipoprotein B (apoB) test at least once because about 20 percent of people have normal LDL and a high apoB.Like low HDL, high fasting triglycerides may indicate insulin resistance as part of the metabolic syndrome and will often respond to lifestyle factors.The lipoprotein known as Lp(a) should also be assessed at least once because it indicates risk when elevated. The good news is scientists are on the cusp of finally having medications to lower it, with five different drugs in late-stage clinical trials.8. Reduce exposure to environmental pollutantsIn recent years, we've learned a lot about the substantial pro-inflammatory effects of air pollution, microplastics and forever chemicals, all of which have been linked to a higher risk of heart disease. In one study, microplastics or nanoplastics in the artery wall were found in about 60 percent of more than 300 people. Researchers found a vicious inflammatory response around the plastics, and a four- to fivefold risk of heart attacks or strokes during three years of follow-up.While we need policy changes to address these toxic substances in the environment, risk can be reduced by paying attention to air and water quality using filtration or purification devices, less use of plastic water bottles and plastic storage, and, in general, being much more aware and wary of our pervasive use of plastics.9. Don't smoke This point, it should be well known that cigarette smoking is a potent risk factor for coronary artery disease and should be completely avoided.10. Get Good SleepAlthough we tend to connect sleep health with brain and cognitive function, there's evidence that sleep regularity and quality are associated with less risk of heart disease. Regularity means adhering to a routine schedule as much as possible, and its benefit may be due to our body's preference for maintaining its circadian rhythm. Sleep quality — meaning with fewer interruptions — and maximal deep sleep can be tracked with smartwatches, fitness bands, rings or mattress sensors.Sleep apnea, when breathing stops and starts during sleep, is fairly common and often unsuspected. So if you're having trouble sleeping or you snore loudly, talk to your doctor about ruling out the condition. Testing for sleep apnea can involve checking for good oxygen saturation throughout one's sleep. That can be done through a sleep study or at home using rings or smartwatches that include oxygen saturation in their sensors and body movement algorithms that pick up disturbed breathing.Eric Topol, MD, is a cardiologist, professor and executive vice president of Scripps Research in San Diego. He is the author of “Super Agers: An Evidence-Based Approach to Longevity” and the author of Ground Truths on Substack.*********************°°°°°°°°°°°°°°°°°°°°Thanks to many of you Ground Truths subscribers who helped put SUPER AGERS on the NYT bestseller list for 4 weeks.Here are 2 recent, informative, and fun conversations I had on the topicMichael Shermer, The SkepticRuss Roberts, EconTalk I'm also very appreciative for your reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past three years. Just a week ago we just had nearly 50 interns (high school, college and medical students) present posters of the work they did over the summer and it was exhilarating! Some photos below Get full access to Ground Truths at erictopol.substack.com/subscribe

Josh Wageman is a board-certified Clinical Lipid Specialist dedicated to transforming the way we understand and treat heart disease. With a deep expertise in cholesterol, metabolic health, and cardiovascular risk, he helps patients cut through the noise and take control of their health using evidence-based, personalized strategies. Known for translating complex science into actionable steps, Josh is passionate about prevention and proving that heart disease doesn't have to be inevitable. In this episode, Dr. Brian and Josh talk about… (00:00) Intro (00:32) Josh's interesting and varied career path (04:31) Understanding cardiovascular disease in a nutshell (8:15) Understanding lipoproteins (10:10) Why lipids are controversial and what we can all agree on (12:28) LDL and HDL particles (19:35) Endurance athletes and coronary calcium (29:54) Atherosclerosis, carnivore, and gut dysbiosis (39:46) Advanced lipid panels (40:29) Statins and LDL (44:13) Pros and cons of statins (49:54) Supplements that may be helpful for cardiovascular health (52:44) Rapping and singing about lipids and heart health (55:09) Science and faith; physical health and spiritual health (01:02:25) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Josh Wageman: IG: https://www.instagram.com/wagemanjosh/ Book: https://www.amazon.com/Security-System-Lipid-Neighborhood-Complicating/dp/B0DTJ1HJ4Y Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

What if changing the water you drink could transform your gut health, lower inflammation, and boost vitality? In this episode of the Beautifully Broken Podcast, Freddie sits down with Dr. Paul Barattiero, founder of Echo Water and pioneer in molecular hydrogen research. Paul shares his journey from helping his wife overcome debilitating health issues to developing one of the most trusted hydrogen water systems in the world. He explains how molecular hydrogen works as a selective antioxidant and signaling molecule, why gut health is the foundation of immune resilience and longevity, and the role of Oxidation Reduction Potential (ORP) in restoring beneficial gut bacteria.You'll also learn how hydrogen impacts oxidative stress, chronic inflammation, brain function, and mitochondrial health; practical methods for using hydrogen such as bottles, baths, and inhalation; and why third-party testing is crucial in a crowded marketplace. Paul shares research-backed benefits ranging from athletic recovery and skin health to fasting support and LDL reduction, offering listeners a clear path to integrating hydrogen into their wellness routine. Hydrogen may be one of the most underutilized wellness tools available today—tune in to discover why this tiny molecule could make a huge impact on your health journey.Episode Highlights[00:00] – Why molecular hydrogen is one of the most underutilized wellness tools on the planet[03:27] – Dr. Paul's personal story: healing his wife's debilitating health issues with hydrogen water[10:44] – Understanding ORP and why gut health is the foundation for immune function[19:30] – How hydrogen manages oxidative stress, inflammation, and brain function[32:20] – Why Echo Water can rehab your gut in just two weeks[36:50] – The Echo Flask: portable, unbreakable hydrogen water on the go[48:43] – Different ways to get hydrogen—drinking, bathing, and inhalation—and which is most effective[55:45] – The history of hydrogen-rich hot springs and their global healing reputation[01:07:11] – Favorite studies: longevity, diabetes, and anti-cancer benefits of hydrogen[01:14:57] – How professional sports teams like the 49ers and Dodgers use Echo Water for recoveryGet ECHO Water: https://www.en4irjswk.com/Beautifullybroken/code: beautifullybrokenWork with me: Work with Me: https://www.beautifullybroken.world/biological-blueprintLinks & ResourcesUse Code: BEAUTIFULLYBROKEN for a MASSIVE discountBEAM Minerals: http://beamminerals.com/beautifullybrokenLightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794code: beautifullybrokenSilver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD30% off Use Code: BEAUTIFULLYBROKEN for DiscountStemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52Code: beautifullybroken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@BeautifullyBrokenWorld)

Send me a text! I'd LOVE to hear your feedback on this episode!My special guest today is Dr. William Davis.  He is a cardiologist and New York Times #1 bestselling author of the Wheat Belly book series. He is Medical Director and founder of the Undoctored program including the Undoctored Inner Circle. He is Chief Medical Officer and co-founder of Realize Therapeutics Corp. that is developing innovative solutions for the disrupted human microbiome and author of the book Super Gut.Get ready to have your understanding of cholesterol and heart disease challenged. Cardiologist Dr. William Davis, bestselling author of the Wheat Belly series, joins us to expose the fundamental flaws in how modern medicine approaches heart health.Dr. Davis reveals why the conventional focus on total cholesterol and LDL is dangerously outdated. These measurements are crude approximations developed in the 1960s that fail to identify the real culprits behind heart disease. Instead, he explains why small dense LDL particles and triglyceride levels are far more meaningful indicators, and why coronary calcium scores provide the most direct evidence of actual heart disease risk.What's truly eye-opening is learning what causes these dangerous small LDL particles. Contrary to popular belief, it's not fatty foods like eggs or butter, but rather grains and sugars. The amylopectin A carbohydrate in wheat (even "healthy" whole grains) triggers small LDL formation more effectively than table sugar. This revelation explains why so many people following conventional "heart-healthy" low-fat, high-grain diets continue developing heart disease.Beyond diet, Dr. Davis delves into how nutrient deficiencies common in modern life—particularly vitamin D, magnesium, iodine, and omega-3 fatty acids—contribute significantly to heart disease risk. He also explores the critical role of gut health, explaining how Small Intestinal Bacterial Overgrowth (SIBO) affects approximately half the North American population and drives inflammation, insulin resistance, and heart disease.Perhaps most importantly, Dr. Davis empowers listeners with actionable knowledge about how to genuinely protect heart health without relying on statins, which he demonstrates provide minimal benefit while increasing diabetes risk. If you're concerned about heart health or have been told ySupport the showPlease rate & review my podcast with a few kind words on Apple or Spotify. Subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgRumble: https://rumble.com/c/c-5461001Linkedin: https://www.linkedin.com/in/sandyknutrition/Substack: https://sandykruse.substack.com/Podcast Website: https://sandykruse.ca

This episode is brought to you by the ⁠⁠⁠Primal Tallow Balms⁠⁠⁠.Dr Kendrick emphasizes the lack of scientific evidence linking high cholesterol to heart disease and argues that a higher fat diet can have positive effects on health. The discussion also covers the complexities of LDL cholesterol, the importance of understanding various health markers, and the potential effects of adopting a high-fat diet. In this conversation, Dr. Malcolm Kendrick discusses the complexities of heart health, focusing on the role of blood clots, the impact of diet on cardiovascular health, and the misconceptions surrounding cholesterol and statins. He emphasizes the importance of understanding the glycocalyx and its protective role in blood vessels, the benefits of a high-fat diet, and the potential for plaque regression. Kendrick also critiques the use of statins, arguing that their benefits are often overstated and come with significant side effects. Takeaways* Cholesterol is often misunderstood in relation to heart disease.* Changing medical opinions is challenging due to entrenched beliefs.* High-fat diets can have positive health impacts.* LDL cholesterol is often mischaracterized as harmful.* The relationship between dietary fat and heart health is complex.* Markers like triglycerides and HDL are important for assessing heart health.* Insulin resistance is a key factor in heart disease risk.* The disease process in arteries can take decades to develop.* LDL levels can be influenced by carbohydrate intake, not just fat.* Understanding the nuances of cholesterol can empower patients. Blood clots form on artery walls and can lead to heart disease.* A high-fat diet can improve blood sugar levels and overall health.* The glycocalyx is crucial for protecting blood vessels from damage.* Diabetes damages the glycocalyx, increasing heart disease risk.* A 30-day high-fat diet can lead to significant health improvements.* Stopping the progression of plaque is more important than regression.* Statins may increase nitric oxide but have many adverse effects.* The average increase in life expectancy from statins is minimal.* Challenging your doctor about statin use can be beneficial.* Understanding the true causes of heart disease is essential for prevention.

In this episode, Brent sits down with Dr. Richard Maurer, a naturopathic doctor and author of The Blood Code, a book about metabolic health. They discuss markers like A1C, LDL, HDL, triglycerides, and how these impact risks for conditions such as diabetes and heart disease. Dr. Maurer shares his personal journey of reversing prediabetes and provides actionable insights on diet, exercise, and maintaining a balance between endurance and weight training to optimize health. The conversation then shifts to Dr. Maurer's approach to his Parkinson's diagnosis. With a focus on information, community, and proactive measures, he details how he has adapted his lifestyle to slow the progression of this neurodegenerative disease. Hope you enjoy.

In this solo episode, I delve deep into a topic that could revolutionise your understanding of cardiovascular health. The focus shifts from the conventional marker, LDL cholesterol, to a more predictive measure that has been right under our noses. Prepare to have your mind blown as I unpack decades of research, dismantles myths, and unveil practical steps for a healthier life. What You'll Learn: The Real Marker of Risk: Discover a much stronger predictor of cardiovascular and metabolic disease risk than LDL cholesterol. Challenging Norms: Understand why relying solely on LDL cholesterol is like flipping a coin when assessing heart disease risk. A Game-Changer: Learn about the Framingham study's revelation that this measure is 3 to 5 times more predictive of heart attack risk. Impacts Beyond Heart Health: Find out how this ratio also predicts risk for metabolic diseases like type 2 diabetes. Practical Steps: Explore dietary and lifestyle changes that can improve your key ratio, enhancing overall metabolic health. Key Takeaways: The triglyceride to HDL ratio offers a more accurate risk assessment than focusing solely on LDL cholesterol. Maximising heart and metabolic health involves more than just medication; lifestyle changes play a crucial role. Understanding your body's response to carbohydrates is key to optimising your lipid profile. The medical community's focus on LDL cholesterol is outdated—empower yourself with current research to guide your health decisions. Simple changes such as low-carb diets, exercise, and intermittent fasting can significantly impact your health outcomes. Support the Podcast: If you enjoyed this episode, consider subscribing and leaving a review on your preferred podcast platform. Your support helps us bring valuable conversations like this one to a wider audience. If this perspective on heart health was enlightening, consider sharing it with friends and family. Encourage them to rethink traditional markers of health and embrace more comprehensive measures. Stay connected with the evolving world of cardiovascular research and empower yourself with knowledge for a healthier, longer life. Final Thoughts: Embrace the shift towards a more nuanced understanding of heart health. As we grow more informed, the tools to live healthier, longer lives are within our grasp—let's use them to navigate our health journey intelligently. 00:00 Introduction and Podcast Name Change 01:31 Today's Topic: Cardiovascular Disease and LDL Cholesterol 03:54 The Limitations of LDL Cholesterol 07:52 The Game Changer Ratio 09:01 Research and Studies on this alternative Ratio 17:20 Practical Applications and Lifestyle Changes 29:32 Medications and Advanced Research 41:25 Conclusion and Key TakeawaysSee omnystudio.com/listener for privacy information.

Send us a textOverview and alternative interpretation to the mainstream view on how dietary fat and cholesterol relate to cardiovascular disease.Episode Summary: Tucker Goodrich is an engineer by training who has become a prominent independent researcher and blogger on nutrition and metabolic health, focusing on the harms of seed oils and polyunsaturated fats.About the guest: Nick Jikomes and Tucker Goodrich explore atherosclerosis and heart disease, critiquing the standard model that blames high LDL cholesterol while highlighting how oxidized LDL—driven by dietary linoleic acid from seed oils—plays a key role in plaque formation and inflammation; they discuss historical shifts in heart disease rates, genetic factors like familial hypercholesterolemia, the limitations of animal studies, and why reducing seed oil intake could prevent issues more effectively than just lowering cholesterol.Discussion Points:Atherosclerosis involves plaque buildup in arteries, often leading to heart attacks, but plaques contain oxidized fats and cholesterol, not just native cholesterol.Dietary cholesterol has little impact on blood levels or heart disease in humans, unlike in rabbits used in many studies.High LDL may not be inherently bad; oxidized LDL from polyunsaturated fatty acids (PUFAs) like linoleic acid causes macrophages to overeat and form harmful foam cells.Familial hypercholesterolemia patients only show higher heart disease rates in modern, industrial diets high in seed oils, not historically.Populations like the Kitavans and Tsimané have high apoB but no heart disease on traditional diets low in industrial foods.Fried foods are oxidized seed oils, explaining why they're unhealthy despite omega-6 fats being labeled "heart-healthy."Omega-3 fats can displace omega-6 in cells, reducing oxidation risk.Reference Papers:Witztum & Steinberg (1991)Boren et al. (2022)Related episode:Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Send us a textWe often hear about heart disease prevention, but stroke—a condition nearly as common and often more disabling—gets far less attention. In this episode, Dr. Bobby is joined by cardiologist Dr. Anthony Pearson to uncover what science really says about stroke prevention, the distinct types of strokes, and what practical steps you can take today to lower your risk.Together, they explore the two major types of stroke—ischemic and hemorrhagic—and explain why strokes caused by clots or vessel rupture can have very different causes and consequences. The data shows nearly 800,000 Americans experience strokes annually, and about half of survivors live with long-term disability (CDC; NIH). Yet most of us are unaware of the modifiable risk factors that account for up to 90% of stroke risk (INTERSTROKE Study).Dr. Pearson emphasizes the number one culprit: high blood pressure. It triples individual risk and contributes to half of all strokes, with randomized trials like SPRINT showing that aggressive control reduces both stroke and mortality (SPRINT Study). Both doctors also discuss physical activity—while Dr. Bobby cites strong associations between exercise and reduced stroke risk (BMJ Review), Dr. Pearson cautions that current evidence is largely observational and inconclusive.They also explore the role of lipid levels, citing that high ApoB or LDL may increase risk in strokes caused by carotid atherosclerosis, but not necessarily in cardioembolic strokes. Dietary improvements, particularly following a Mediterranean-style diet, have shown benefits, including reduced stroke risk in randomized trials like PREDIMED.Beyond traditional risk factors, they also explore loneliness as a newer area of concern. A recent study linked persistent loneliness in adults over 50 to a 50% increased stroke risk (Lancet eClinicalMedicine), highlighting the complex social and behavioral factors at play.Dr. Pearson discusses atrial fibrillation (AFib) and why it's a key cause of cardioembolic strokes—especially relevant given that wearables like Apple Watch now help detect AFib early. They also touch on controversial screening approaches, warning against routine carotid ultrasounds and unwarranted treatment of asymptomatic brain aneurysms.Importantly, Dr. Bobby highlights the signs of stroke—sudden weakness, numbness, speech difficulties, or confusion—and urges immediate ER visits to enable timely treatment like thrombolysis, ideally within four hours of symptom onset.As always, they wrap by challenging popular myths. Dr. Pearson explains why aspirin, once widely promoted for primary prevention, is no longer recommended due to increased bleeding risk, especially into the brain. He also debunks the idea that supplements like fish oil or B vitamins help prevent strokes, noting no benefit in recent large trials.Takeaways:Know your blood pressure and cholesterol levels—and treat them if needed. These remain the top modifiable risks for stroke.Prioritize physical activity, even if trial data is imperfect—it benefits vascular health broadly and may reduce stroke risk.Stay socially connected: chronic loneliness has emerging links to stroke risk, highlighting that prevention isn't just physical—it's relational.To continue learning how to live long and well, visit drbobbylivelongandwell.com.

In this episode, I sit down with Dr. Rupy Aujla, an NHS GP and the founder of The Doctor's Kitchen, an app that includes doctor-approved recipes to cook at home. In this conversation, we dive into why cardiovascular disease remains the #1 killer worldwide, the connection between cholesterol and heart health, how fiber acts as a “magical nutrient” for the body, how to introduce it into your daily meals, and the role of lifestyle choices in preventing illness and supporting long-term brain and heart health. *** About Dr. Rupy Aujla: After suffering a significant heart condition, he dove deep into the science of nutritional medicine and was able to reverse his condition through food and lifestyle. In 2015, he launched The Doctor's Kitchen as a way to teach people how to cook their way to better health and to showcase the medicinal effects of eating well. The incredible “Doctor's Kitchen” cooking app has over 1000 delicious, science-backed recipes and 20 brand new ones added each month. There's also a handy meal planner that will personalise recipes based on your preferences. It actually suggested a delicious looking salmon poached in harissa coconut sauce, and  olive and date braised chicken, which suit my personal dietary needs and all sound great. You can download and use the app completely for free using this link. *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: David's Protein: Buy four cartons and get your fifth one completely free | Head to https://davidprotein.com/pages/neuro Ketone IQ: Go to https://ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment. FIGS: You can get 15% off your first order at https://wearfigs.com with the code FIGSRX. Caraway: https://caraway.com/neuro for an additional 10% off your purchase MUDWTR: The coffee alternative. If you're ready to ditch the crash and sip smarter, go to https://mudwtr.com and use code NEURO to get 43% off + free shipping. *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics: 00:02:43: Lipid panels & overlooked markers 00:05:21: Atherosclerosis explained 00:08:13: Misleading “normal” cholesterol panels 00:10:48: Why heart disease remains #1 killer & prevention timeline 00:12:51: Cholesterol & Alzheimer's; LDL targets for brain health 00:15:12: Cholesterol causality, very low LDL safety 00:19:23: Statins & pharmacological interventions 00:26:02: Ultra-processed foods & saturated fats 00:29:26: Fiber's role in lowering LDL 00:32:05: How fiber binds bile acids & removes cholesterol 00:33:29: Gut microbiome & short-chain fatty acids from fiber 00:35:05: Lowering ApoB, LDL by eating plant-rich foods, portfolio diet 00:37:15: Oats & heart health 00:41:51: Pesticides in fruits and vegetables 00:45:37: Eggs and cholesterol 00:48:18: Soy 00:53:55: Balanced eating 00:57:40: Stress, sleep & cardiovascular disease 00:59:55: Memorable patient stories, family member with stent 01:04:04: How to reduce risk of heart attack or stroke with diet Learn more about your ad choices. Visit megaphone.fm/adchoices

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Literature Review 1) An exciting phase three trial with the CETP inhibitor Obicetrapib has shown serious promise for ASCVD and Alzheimer's Disease (AD). "In BROADWAY, a pre-specified AD sub-study was designed to assess plasma AD biomarkers in patients enrolled in the BROADWAY trial and evaluated the effects of longer duration of therapy (12 months) with a prespecified population of ApoE3/4 or 4/4 carriers. The sub-study included 1727 patients, including 367 ApoE4 carriers. The primary outcome measure was p-tau217 absolute and percent change over 12 months. Additional outcome measures included neurofilament light chain (“NFL”), glial fibrillary acidic protein (“GFAP”), p-tau181, and Aβ42/40 ratio absolute and percent change over 12 months. NewAmsterdam observed statistically significant lower absolute changes in p-tau217 compared to placebo over 12 months in both the full ITT population (p

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Saturated fat -- not eggs -- is the key culprit behind high LDL cholesterol, which can lead to cardiovascular disease And in fact, a diet low in saturated fat and high in dietary cholesterol, such as that found in eggs, can lower blood cholesterol levels. This -- according to a new study from researchers at the University of South Australia.   But what are we to make of this study, which received funding from an offshoot of the American Egg Board, an organization focused on marketing and promoting eggs?   Dr. Neal Barnard joins Chuck Carroll on this episode of The Exam Room to tell us what he makes of these findings, and to answer your questions about saturated fats, dietary cholesterol and eggs.   In this episode of The Exam Room, you'll learn:   - Whether eggs raise cholesterol for everyone - Whether eggs egg whites and free-range eggs are healthier options - Dr. Barnard's favorite egg substitutes - Whether eggs or meat and dairy have a greater impact on cholesterol - How many eggs are safe to eat per week - How saturated fat influences cholesterol absorption - How quickly eggs can raise cholesterol - Genetic factors that influence cholesterol   This episode is sponsored by The Gregory J. Reiter Memorial Fund, which supports organizations like the Physicians Committee that carry on Greg's passion and love for animals through rescue efforts, veganism, and wildlife conservation.   — — SHOW LINKS — — Gregory J. Reiter Memorial Fund https://gregoryreiterfund.org — — — Shelfy Refrigerator Purifier https://vitesy.com/shelfy — — — Egg Cholesterol Study https://bit.ly/eggstudy2025 — — EVENTS — — International Conference on Nutrition in Medicine Where: Washington, DC When: August 14-16, 2025 Tix & Speakers: https://www.pcrm.org/icnm Use code NUTRITION50 to save $50 — — — Fit Vegan Workshop Where: Vancouver, BC, Canada When: Sept. 20-21, 2025 Tix: https://fitvegancoaching.com/vancouver-2025 Use code CHUCK to save $112 — — — Wellness Weekend Where: Canaan Valley Resort - Davis, WV When: Sept. 26-27, 2025 Tix & Speakers: https://www.brendaworkmanspeaks.com/wellness-weekend   — —EXAM ROOM — — Newsletter: https://www.pcrm.org/examroomvip Instagram: https://www.instagram.com/theexamroompodcast — — — Dr. Neal Barnard Books: https://amzn.to/3HhVlrF Instagram: https://www.instagram.com/drnealbarnard Facebook: https://www.facebook.com/NealBarnardMD X: https://x.com/DrNealBarnard — — — Chuck Carroll Instagram: https://www.instagram.com/ChuckCarrollWLC Facebook: https://www.facebook.com/ChuckCarrollWLC X: https://www.twitter.com/ChuckCarrollWLC — — — Physicians Committee Instagram: https://www.instagram.com/physicianscommittee Facebook: https://www.facebook.com/PCRM.org X: https://www.twitter.com/pcrm YouTube: https://www.youtube.com/user/PCRM Jobs: https://www.pcrm.org/careers — — SUBSCRIBE & SHARE — — 5-Star Success: Share Your Story Apple: https://apple.co/2JXBkpy​​ Spotify: https://spoti.fi/2pMLoY3 — — — Please subscribe and give the show a 5-star rating on Apple Podcasts, Spotify, or many other podcast providers. Don't forget to share it with a friend for inspiration!

In this conversation, Dr. Elizabeth Klodas, a preventive cardiologist and founder of Step One Foods, discusses the critical role of nutrition in managing heart disease and the challenges faced in integrating dietary changes into medical practice. She shares her journey from traditional medicine to creating a food company aimed at reducing reliance on medications through nutrition. The discussion highlights the importance of randomized controlled trials in validating the effectiveness of food-based interventions, the impact of pharmaceuticals on healthcare, and the need for a shift in consumer perceptions towards whole food ingredients. Dr. Klodas emphasizes the potential for a healthier future where cardiologists are less needed due to preventive measures and lifestyle changes.Takeaways:Nutrition is often overlooked in favor of pharmaceuticals in healthcare.Patients are rarely asked about their diet by healthcare providers.Changing dietary habits can lead to significant health improvements.Pharmaceuticals are easier to prescribe than dietary changes.There is a lack of nutrition education in medical training.Step One Foods aims to fill nutritional gaps in patients' diets.Randomized controlled trials can validate the effectiveness of food products.Consumer perceptions of health foods can be influenced by marketing.The food industry often prioritizes cost over nutrition.A better world would mean fewer cardiologists needed due to preventive health measures.Sound bites:“There is very little to no nutrition education for physicians. As I look back on this I consider this educational malpractice.”“All the medical evidence of what we should be doing is very heavily pharma biased, because guidelines are based on randomized control clinical trials.”“So there's loads of reasons why nutrition is not used in clinical care the way it should be. None of that is an excuse though, because it works and it's so vital.”“What if I asked you to like eat this food twice a day and I otherwise left you alone? What started happening is people calling and saying, hey, my cholesterol dropped 39 points. Then I'm like, okay, we're gonna subject our products to a randomized control trial. Let's see. Let's prove it. Does this actually work?”“If I reduce, LDL, the bad cholesterol across the US population by an average of 9%, I will finally dethrone heart disease as our number one killer.”“In that trial, we replicated what people were calling in with our highest LDL reduction was close to 40 % in 30 days. That's a medication level cholesterol reduction. And we did that with food, without turning people's lives upside down.”“It's not just the nutrient of interest that's important. It's the delivery vehicle. You can stuff a bunch of fiber into a Twinkie. But in the end, you're still eating a Twinkie, right? Food and nutrition is complex.”“At Step One Foods I take the complexity out for people. I take whole food ingredients, each and every single one that has data behind it in terms health benefits, and put them in my foods.”“We are probably the most overfed and undernourished society in the history of our species.”“If you truly believe in your mission, you have to ignore all the no's.”Promo Offer:Code: BETTERWORLDLink: https://www.steponefoods.com/discount/BETTERWORLDOffer: 10% off first order for both one time and subscription orders. Offer can be stacked with the subscription discount to save 30% on their first order. Exclusions: Limited to one use per customer. Limited to a customer's first order and only applies to the first recurring order. Code must be entered at checkout for the discount to be applied. Links:Dr Elizabeth Klodas on LinkedIn - https://www.linkedin.com/in/eklodas/Step One Foods- https://www.steponefoods.com/Step One Foods on LinkedIn - https://www.linkedin.com/company/steponefoods/Step One Foods on Facebook - https://www.facebook.com/StepOneFoodsStep One Foods on Instagram - https://www.instagram.com/steponefoods/Step One Foods on YouTube - https://www.youtube.com/StepOneFoods…“Slay the Giant: The Power of Prevention in Defeating Heart Disease” book - https://www.steponefoods.com/products/slay-the-giant…Brands for a Better World Episode Archive - http://brandsforabetterworld.com/Brands for a Better World on LinkedIn - https://www.linkedin.com/company/brand-for-a-better-world/Modern Species - https://modernspecies.com/Modern Species on LinkedIn - https://www.linkedin.com/company/modern-species/Gage Mitchell on LinkedIn - https://www.linkedin.com/in/gagemitchell/…Print Magazine Design Podcasts - https://www.printmag.com/categories/printcast/…Heritage Radio Network - https://heritageradionetwork.org/Heritage Radio Network on LinkedIn - https://www.linkedin.com/company/heritage-radio-network/posts/Heritage Radio Network on Facebook - https://www.facebook.com/HeritageRadioNetworkHeritage Radio Network on X - https://x.com/Heritage_RadioHeritage Radio Network on Instagram - https://www.instagram.com/heritage_radio/Heritage Radio Network on Youtube - https://www.youtube.com/@heritage_radioChapters:03:00 Introduction to Preventive Cardiology and Nutrition05:58 The Shift from Nutrition to Medication in Healthcare08:45 The Role of Pharmaceuticals in Patient Care11:41 The Challenges of Nutrition Education in Medicine14:41 The Complexity of Food and Nutrition Science17:59 Step One Foods: A New Approach to Nutrition20:57 The Impact of Randomized Controlled Trials on Nutrition23:59 The Importance of Ingredient Quality in Food Products26:49 Pushback from the Medical and Food Industries29:52 The Insurance Industry's Role in Healthcare Costs32:52 Step One Foods: Product Overview and Benefits38:43 Introduction to Whole Foods and Health Claims40:56 The Importance of Real Ingredients42:56 Navigating Organic Ingredients and Supply Chain Challenges44:59 Stepwise Approach to Health and Nutrition48:58 Challenges in Scaling Food Production51:49 Milestones and Industry Changes56:55 Advice for Aspiring Food Entrepreneurs59:50 Personal Indulgences and Food Preferences01:03:00 Innovative Thinkers in Nutrition01:05:50 Vision for a Healthier WorldSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why do we screen for cancer but not the leading cause of death — heart disease? Today, we explore innovative strategies for early detection, prevention, and effective intervention in cardiovascular health.Join hosts Dr. Emmie Brown, ND, and Melissa Gentile, INHC, as they welcome Dr. Joel Kahn, a renowned cardiologist and advocate for plant-based nutrition and holistic approaches to heart health. Dr. Kahn delves into why heart disease has stubbornly remained the leading cause of death despite medical advancements, highlighting the need for a paradigm shift in prevention and early detection.Dr. Kahn critiques the current lack of attention paid to proactive cardiovascular screening, noting the puzzling discrepancy between routine cancer screenings and the absence of widespread use of tools like coronary artery calcium (CAC) CT scans for asymptomatic adults. He champions a personalized, comprehensive approach, moving beyond basic lipid panels and into genetic testing, advanced inflammatory markers, and detailed imaging.They also discuss dietary strategies, including debates on the role of protein and seed oils in heart risk, the importance of the endothelial glycocalyx, and recommendations for clinicians to assess and communicate vascular risk. Dr. Kahn challenges both traditional and trendy wellness beliefs, promoting evidence-based, personalized strategies in integrative cardiology.Key Takeaways from Today's Episode:

In this compelling conversation, Psychiatrist & Health Influencer Paul Saladino advocates for the simplicity of eating real, whole foods and discusses their profound impact on chronic illness, mental health and overall well-being. At the core of this discussion is the importance of eating meat or maintaining a “carnivore” diet, something he says might not be right for everyone but is certainly beneficial for many. He details the detrimental effects of processed foods and funding-driven misinformation within the health industry. Saladino shares personal anecdotes, including the influence of his family's health issues on his career in medicine and nutritional science, his journey with vegan and carnivore diets and the adjustments in his dietary philosophy. He emphasizes the significance of metabolic health over conventional LDL-focused approaches to cardiovascular disease, touching on topics like LDL cholesterol, insulin sensitivity and the pitfalls of overreliance on statins. Additionally, he delves into his favorite forms of exercise, his thoughts on supplementation,and the impact of modern lighting (and lightbulbs) on health. The conversation wraps up with practical advice for achieving health by aligning more closely with the body's natural state and removing systemic impediments. Thank You to Our Sponsors Lineage - Get 15% Off Lineage Provisions with the code GABBY by going to ⁠lineageprovisions.com/GabbyReece Ritual - Get 25% off your first month or or add Essential For Women 18+ to your subscription at ritual.com/GABBY Troscriptions - Give it a try at troscriptions.com/GABBY or enter GABBY at checkout for 10% off your first order   CHAPTERS 00:00 Introduction to Real Food 02:17 Personal Health Journey 09:27 The Carnivore Diet Experiment 13:36 Challenges and Adjustments 14:50 The Role of Insulin and Electrolytes 17:01 Public Perception and Personal Evolution 28:51 Fruit and Seasonal Eating 31:07 Supplementation and Nutrient Deficiency 39:43 The Importance of Sunlight and Natural Light 43:20 The Role of Diet in Skin Health 48:27 The Impact of Indoor Lighting on Health 53:13 The Importance of Protein and Collagen 58:21 Cholesterol: Myths and Facts 01:10:10 The Liver King Controversy 01:16:56 Paul Saladino's Fitness Routine 01:18:49 Final Thoughts and Health Tips FOR MORE ON PAUL SALADINO, MD Paul Saladino's Website Paul Saladino's Podcast The Carnivore Code: Unlocking The Secrets to Optimal Health by Returning to Our Ancestral Diet written by Paul Saladino, MD The Carnivore Code Cookbook: Reclaim Your Health, Strength and Vitality with 100+ Delicious Recipes by Paul Saladino, MD  Follow Paul Saldino on Instagram  For more on Gabby Instagram ⁠@GabbyReece⁠ TikTok ⁠@GabbyReeceOfficial ⁠  The Gabby Reece Show Podcast on YouTube: YouTube: ⁠https://www.youtube.com/@GabbyReece⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Story at-a-glance Dragon fruit delivers antioxidant protection, gut support, and metabolic benefits, making it an easy way to upgrade your fruit intake Research shows that 100 grams of dragon fruit, about 1/2 cup, daily lowers LDL cholesterol by up to 69%, raises HDL by over 60%, and reduces triglycerides within weeks Bioactive compounds in the flesh, seeds, and even peel help fight inflammation, protect your liver, and feed beneficial gut bacteria like Akkermansia and Lactobacillus Dragon fruit's natural sugars provide steady energy without blood sugar crashes, making it an ideal pre-workout snack or midday pick-me-up It's especially helpful for pregnancy, digestive sluggishness, and skin repair, thanks to its folate content, natural hydration, and collagen-boosting vitamin C

Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the importance of understanding cholesterol in his podcast. He explains that cholesterol is crucial for cell membranes, hormone formation, and vitamin transport, and that LDL and HDL are transport vehicles for cholesterol. Dr. Bishop clarifies that cholesterol's impact on heart health is complex, as high LDL doesn't always indicate artery plaque, and low cholesterol doesn't always mean healthy arteries. He emphasizes the importance of coronary artery calcium scoring, particle numbers, and other factors in assessing artery health and predicting risk. For secondary prevention, lowering cholesterol is crucial, while primary prevention requires a personalized approach, considering individual risk factors and imaging.

The idea that saturated fat might be harmful to our health has sparked controversy for decades. In recent years, counter-narratives have surged: suggesting that concerns over saturated fat were overblown, that LDL cholesterol doesn't matter, or that the original diet-heart hypothesis has been debunked. These claims have become especially popular in online wellness spaces and certain dietary communities, often wrapped in compelling but misleading rhetoric. So what does the best available evidence actually say? And how should we think about saturated fat, LDL cholesterol, and cardiovascular risk in the current day? In this wide-ranging interview, originally recorded for the Chasing Clarity podcast, Alan and Danny explore the scientific consensus around saturated fat's impact on blood lipids, why LDL and apoB are central to atherosclerotic disease, and how dietary patterns can meaningfully reduce risk. Importantly, they also address some of the most persistent myths and half-truths that fuel confusion, from flawed interpretations of the Seven Countries Study to misrepresentations of newer meta-analyses. Timestamps [03:41] How do we know saturated fat impacts LDL-C? [05:28] Metabolic ward studies and key findings [11:13] The Keys equation and subsequent research [17:17] Epidemiology and long-term studies [31:48] The Seven Countries Study [44:25] Understanding the impact of saturated fat on blood lipids [47:23] Historical and research perspectives on saturated fat [50:43] Practical dietary strategies for improving blood lipids [53:48] The Portfolio Diet and other dietary interventions [58:07] The role of pharmacology in managing blood lipids [01:00:58] Addressing misconceptions and common claims [01:13:57] Key ideas segment (premium-only) Related Resources Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course Alan Flanagan's Alinea Nutrition Education Hub Related episodes to add to your podcast queue: 532, 525, 515, 493, 481, 439