Podcasts about ldl

Send us Fan MailDr. Austin Dudzinski is a Clinical Pharmacist at Think Whole Person Healthcare, and enjoys working with cardiometabolic disorders, especially diabetes and dyslipidemia.Think Whole Person Healthcare partners with physicians in many areas of care, keeping primary care, specialists, and diagnostics all under the same roof, saving their patients time, emotional effort, and money.What Dr. Dudzinsky finds most exciting about working in Medicine is that there are always innovations on the horizon, especially in preventive medicine for diseases such as cancer and dementia. He has known he's wanted to work in this field since college.What Dr. Dudzinski loves most about working at think is that it provides him with the opportunity to use the entire body of knowledge that he has learned and apply it to help patients. If asked, he thinks his patients would say he's, “The bald pharmacist that calls them about their diabetes.”When he's not at work, he enjoys playing guitar, exercising, reading medical literature, and hanging out with his wife and son.Find Dr. Dudzinsky at-TW/X- @ApoDudzhttps://thinkhealthcare.org/Find Boundless Body at-myboundlessbody.comBook a session with us here! 

This week we talk about LDL, HDL, and cardiovascular issues.We also discuss one-time therapies, statins, and pharmaceutical economics.Recommended Book: Blood by Dr. Jen GunterTranscriptCholesterol is the most common type of what's called a sterol, which is a type of steroid, but also structurally technically an alcohol. But functionally, and classified by scientists, cholesterol is a lipid, which in this case is similar to a fat in all but how the body uses it. Cholesterol is the type of sterol most commonly found in animals—other types are found in plants and fungi—and its function, and this is where it varies from fats, which are used to store energy, is to basically help hold the cell membrane together, and it also serves as an intracellular messenger.Cholesterol is especially prevalent in the brain and spinal cord of animals, but it's found throughout their bodily tissues, as well, and again, it's vital for holding everything together and helping things communicate, in addition to being a precursor for vitamin D, steroid hormones, and bile.You want to have cholesterol, then, as without it you would be dead.Too much cholesterol in the blood, however, can also make you dead, especially when it's bound to what's called low-density lipoprotein, or LDL, as that contributes to cardiovascular disease like heart attacks and aneurysms, which can massively impact one's overall wellness and quality of life, and at extremes lead to the whole system shutting down as a consequence of heart attack, stroke, and the like.A lot of things can contribute to the development of cardiovascular disease, including habits like smoking, genetic predisposition, and the enthusiastic consumption of alcohol and unhealthy foods. But high blood cholesterol, of the LDL variety, is one of the top contributors, as these low-density clusters of lipoprotein can clog the pathways that blood takes throughout our bodies. Other, denser types of lipoproteins, HDLs, can clear it, like a heavier, denser substance pushing through clogs of less-dense materials that are gumming up a pipe, but LDL is at times accumulated as a result of consuming delicious but unhealthy foods, which are hard to avoid, and for some people the only consistently available and affordable foods; and for other people LDL accumulates as a result of their genetic predispositions—two things that are devilishly difficult to change.What I'd like to talk about today is a new type of therapy that may be very good news for people who struggle with the accumulation of LDL, and why this is being seen as very good news more broadly, at the scale of entire nations, as well.—Pharmaceutical company Eli Lilly is testing a new, experimental drug called VERVE-102 which is a one-time infusion that is currently administered over the course of about four hours, and once completed, it turns off a gene called PCSK9, which is responsible for making a protein that regulates cholesterol levels in humans.As I said, this drug is still being tested, so these are early results. But in a study of 35 people with high cholesterol levels, high levels of LDL or LDL-C, which is short for lipoprotein cholesterol, they found that this infusion, which again, is a one-time treatment, so get it once and then theoretically at least you never have to get anything done ever again, it reduced those LDL and LDL-C levels by as much as 62%, and that reduction was maintained a year and a half after the infusion; that's how far out they're retested so far, and the hope is that each retest will continue to show the same.On the strength of those very promising results, a Phase 2 study has been planned by the end of 2026, and the US Food and Drug Administration, the FDA, previously fast-tracked this existing study, because of the promise and potential this drug already demonstrated in early studies; all of which is considered to be very significant progress and possibility.To understand that significance, though, it's useful to know some health stats. And I'm going to focus on the US here, as that's where this drug is being developed, but many wealthy countries have similar stats, at least in terms of cardiovascular disease struggles.As of 2024, which is the last year we had good, cohesive data on this in the US, it was estimated that about 11-12% of the US adult population has high cholesterol levels. This typically doesn't come with any symptoms, but it can contribute a higher risk for all those cardiovascular diseases, including heart attack and stroke. A further 86 million US adults have borderline or elevated cholesterol levels, which can easily tip higher, but also, even in that existing, elevated state, contribute to negative cardiovascular outcomes.There are treatments for high cholesterol, the most common of category of which are called statins, which reduce the production of LDL by inhibiting an enzyme that produces cholesterol in the body.Unfortunately, these drugs do come with some usually minor side effects, which can cause patients to stop using them, and they have to be taken daily, ideally at the same time each day. That necessity for consistency leads to a lot of incorrect or incomplete usage, which reduces the effectiveness of these drugs. But it's also estimated that only about 54.5% of US adults who would benefit from statins are currently taking one—so that's people who could benefit and who have it prescribed, and then within that number are all the people who are taking this drug incorrectly or incompletely, reducing the effectiveness. So a relatively small number of people who should probably be on these things are getting the full benefit they offer because of the nature of the drug.And that's not great, because in the US alone, heart disease is the leading cause of death for pretty much every adult demographic; men, women, people of most racial and ethnic and economic groups, you name it, heart disease is the biggest threat to their lives.One US citizen dies every 34 seconds of some kind of cardiovascular condition, and as of 2023, 1 in every 3 deaths in the US was caused by the same, adding up to just over 919,000 people that year.Between 2021 and 2022, alone, the cost of services and medications related to heart disease added up to more than $168 billion; again, that's just in that period, and just in the US.And once more, these are ailments that are caused or heavily influenced by high levels of cholesterol, which are themselves amplified by common lifestyle choices, environmental factors that are hard for many people to avoid, and just by raw, dumb luck because of genetics.This treatment category, then, is being seen as a pretty big deal because a one-time infusion means those who receive it don't have to remember to take a pill every day at the same time, and won't experience those statin-based side-effects.It also means that people who are currently costing the medical system a bunch of money each year, because they need treatments for all the issues they suffer as a result of high cholesterol, will suddenly cost the system a lot less money, for treatments and medications. Not for nothing, their health and quality of life will likely improve as well. So in addition to having better, healthier outcomes personally, their cost to healthcare systems will drop.Eli Lilly's drug isn't the only one currently working its way through clinical trials, either.Amgen is working on a similar treatment, and Novartis and Ionis Pharmaceuticals have drugs that are even further along in the process, their medicines that cut heart attacks, strokes, and cardiovascular deaths could be approved by the FDA as soon as next year.There are a lot of caveats worth noting here, including that the science is still out as to whether this approach, silencing proteins that lead to the creation of more LDL and a similar substance called Lp(a)—which is more dangerous because it's stickier and thus more likely to get stuck in important blood pathways, and it's also more likely to be caused by genetics than lifestyle—the word is still out on whether reducing these things in the body actually reduces hearth attacks and stroke.Some people have had this particular risk variable dramatically reduced, but have still suffered from cardiovascular events, which raises the question of whether this path is the right one to take in trying to reduce this category of health issues; the correlation between LDL and heart attacks and strokes might not be a clear-cut as long assumed.There's also the issue of price. Drug-makers are economically incentivized to sell treatments over cures, because that means they can continue selling their product over time, potentially for the life of the patient, and a cure, in contrast, is a one-time hit that in theory should alleviate the need for future treatment.There's a chance, then, that the drug-makers will decide they need to make these one-hit treatments really, really expensive in order to make their R&D dollars back and to make the kinds of profits their investors expect from them. That could then reduce the potential audience for these treatments, even if they are effective, and could further slow their deployment and future research in this space.If these trials continue to go well, though, there's a good chance that this combination of similar but distinct treatment types will provide a more sustainable alternative to current options, and that, like the recent bogglingly rapid and widespread deployment of GLP-1 treatments for all sorts of issues, could lead to a new paradigm in this facet of the medical world.Show Noteshttps://en.wikipedia.org/wiki/Cholesterolhttps://en.wikipedia.org/wiki/Cardiovascular_diseasehttps://en.wikipedia.org/wiki/High_cholesterolhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10982736/https://www.cdc.gov/heart-disease/data-research/facts-stats/index.htmlhttps://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1https://www.ama-assn.org/public-health/chronic-diseases/what-doctors-want-patients-know-about-high-cholesterolhttps://en.wikipedia.org/wiki/Statinhttps://pubmed.ncbi.nlm.nih.gov/42187087/https://abcnews.com/GMA/Wellness/new-drug-game-changer-people-high-cholesterol/story This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe

“What's good for the heart is good for the head.”  Key Links & Resources  Watch the How Not to Die  documentary:  https://nutritionfacts.org/video/how-not-to-die-documentary/  Get How Not to Die  by Dr. Michael Greger: https://amzn.to/49Ffmni   Visit NutritionFacts.org:  https://nutritionfacts.org/  Dr. Greger's Daily Dozen:  https://nutritionfacts.org/daily-dozen/  Lower LDL Cholesterol Naturally with Food:  https://nutritionfacts.org/book/portfolio/  Subscribe to Age Better Cheat Sheet on Substack:  https://barbarahannahgrufferman.substack.com/  How Not to Die Too Soon: Dr. Michael Greger on Food, Cholesterol & Aging Better  In this episode of Age Better,  I'm joined by Dr. Michael Greger, one of the most recognized voices in lifestyle medicine and evidence-based nutrition, and the New York Times bestselling author of How Not to Die, How Not to Diet, and How Not to Age.  We're talking about the new How Not to Die  documentary, created to celebrate the 10th anniversary of his landmark book, and what its message means now — especially for women in their 60s and beyond who want to protect their heart, brain, bones, muscles, energy, and independence.  Dr. Greger shares why food is not just about weight or willpower, but one of the most powerful tools we have to influence how we age. We talk about the connection between artery health and brain health, why cholesterol matters so much, what to do if a whole-food, plant-based diet does not lower LDL enough, and his take on one of the most debated foods in the kitchen: olive oil.  We also get into protein, muscle, bone health, B12, vitamin D, omega-3s, creatine, and why this way of eating does not have to be all-or-nothing.  What You'll Learn in This Episode  Why the message of How Not to Die  may be even more urgent 10 years later  How Dr. Greger's grandmother helped shape his mission as a physician  Why heart health and brain health are deeply connected  What women should understand about cholesterol, LDL, and the Portfolio Diet  Which foods may help support healthier cholesterol levels  Dr. Greger's current thinking on olive oil  How women can get enough protein on a whole-food, plant-based diet  What nutrients deserve special attention, especially B12, vitamin D, and omega-3s  Why resistance training still matters for muscle and strength  How creatine may fit into the conversation around aging and muscle  Why it's never too late to start eating better  The three foods Dr. Greger most wants people to add: berries, dark leafy greens/cruciferous vegetables, and legumes  The three things he suggests cutting back on first: trans fats, processed meats, and sugar-sweetened beverages  As always, talk with your own healthcare provider before making major changes to your diet, medications, or supplements — especially if you have heart disease, high cholesterol, osteoporosis, or other medical concerns.  And I'd love to hear from you. If you have an idea for a future episode or a guest you'd like me to interview, send me a note at  agebetterpodcast@gmail.com.  Please subscribe or follow Age Better  wherever you listen, and don't forget to check out my newsletter, Age Better Cheat Sheet, on Substack for more smart, science-backed tools to help you stay strong, healthy, and independent for the long haul. 

Can ketogenic therapy challenge mainstream thinking on cholesterol, diabetes, and evidence-based medicine? At the CoSci conference, Dr. Ken Berry shares his reaction to The Cholesterol Code documentary and explains why more clinicians are questioning long-standing assumptions about metabolic health, LDL cholesterol, and the treatment of chronic disease.In this conversation, Dr. Berry discusses the growing tension between clinical guidelines, pharmaceutical influence, and real-world patient outcomes, while making the case for curiosity, individualized care, and the power of “citizen science” in medicine.In this episode, we cover:Dr. Ken Berry's reaction to The Cholesterol Code documentaryWhy ketogenic therapy challenges conventional risk-benefit analysisThe role of anecdotal evidence and N=1 experimentationPharmaceutical influence on clinical guidelinesWhy many diabetes patients feel stuck despite following standard adviceThe launch of the American Diabetes SocietyType 2 diabetes remission and low-carbohydrate nutritionWhy doctors need to stay curious and continue learningOne of the biggest themes throughout this conversation is that medicine works best when clinicians and patients stay open-minded, ask better questions, and focus on addressing root causes as opposed to just managing symptoms or lab numbers.

In Part 2 of this special two-part series on genetic lipid disorders, Susan Robbins welcomes back renowned lipidologist Dr. Tom Dayspring for an eye-opening discussion on Lipoprotein(a), often written as Lp(a), one of the most common yet overlooked genetic cardiovascular risk factors in the world. While many people focus on standard cholesterol numbers, Dr. Dayspring explains why Lp(a) deserves far more attention and why major cardiovascular organizations now recommend that every person be tested at least once in their lifetime.Together, Susan and Dr. Dayspring break down the science behind Lp(a), how it differs from traditional cholesterol markers, and why elevated levels can significantly increase the risk of atherosclerosis, stroke, and aortic valve disease. They discuss the role genetics play in determining Lp(a) levels, why lifestyle changes remain important even when they do not directly lower Lp(a), and how advanced testing can provide a more complete picture of cardiovascular risk.This conversation also tackles common misconceptions surrounding cholesterol, statins, and influencer-driven health advice. Dr. Dayspring shares practical guidance on what to do if you discover you have elevated Lp(a), how to advocate for yourself within the healthcare system, and why understanding your unique biology is essential for protecting long-term health.In this episode:What Lipoprotein(a) or Lp(a) is and why it mattersWhy Lp(a) is one of the most common genetic lipid disorders worldwideThe connection between elevated Lp(a), heart disease, stroke, and aortic valve diseaseWhy every person should consider being tested for Lp(a) at least onceHow genetics determine Lp(a) levels throughout lifeThe difference between Lp(a), LDL cholesterol, and ApoBWhy standard cholesterol testing may miss important cardiovascular risk factorsThe role of oxidized phospholipids in cardiovascular diseaseIf you've ever been told your cholesterol is "normal" but still have a family history of heart disease, stroke, or unexplained cardiovascular events, this episode offers critical information that could help you ask better questions, pursue the right testing, and become a stronger advocate for your own health.Learn more about Dr. Tom Dayspring on the website shownotes!https://healthyawakening.co/2026/06/15/episode128/RESOURCES:Connect with Dr. Tom DayspringX: https://x.com/drlipidhttps://familyheart.org/https://healthyawakening.co/2026/06/15/episode128/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Matt: Hi Dr Cabral, I'm constantly trying to improve my sleep but can rarely ever get more than 6 to 6 1/2 hours consistently. If I go to bed earlier, I wake up earlier ready to go. Right now I'm taking 2g of taurine, balanced zinc, 500mg magnesium, 100mg theanine, 50mg Apagenin and 3g of glycine. I have no problem falling asleep but consistently wake up around 3-4am. I recently added some Inositol to help get back to sleep but I can't really remember the last time I went to sleep and woke up the next morning by my alarm clock. Just to note, I'm 45 with 3 kids that also like to pop in our room in the middle of the night. Any tips to help get that 7-8 hours I need?       Tricia: Hello Dr C! I'm 57 and I tested my estrogen and progesterone. I'm of course estrogen dominant. I started taking your progesterone support and gosh it is amazing! My sleep has gotten even better! My question is do you think I should take the estrogen supplement too to help balance the two? Are these usually lifetime supplements for post menopausal women? Thanks     Kevin: Just received my annual labs back for annual physical and total Cholesterol is 299, Triglycerides 70, HDL 105, LDL 180, ratio 3.8, and LDL Direct at 182. I have Hashimoto disease, candida for past couple of years and mycotoxins from mold exposure. I cant afford to move out of house so I'm still exposed. I had a functional doctor but can no longer afford the out of pocket expenses. I was on cholestramine powder along with binders but stopped doing them last year because not helping. I'm really worried about having stroke or heart attack. I don't know where to start anymore and been told without moving nothings going to work. What do you recommend I do.? I plan on purchasing Proteolytic Enzymes with Nattokinase to hopefully reduce plaque. What tests do you think would be best for me?       Sienna: Hi Dr. Cabral - hoping you can help! In a country where FM labs aren't an option + entering into mid-40's, surrounded by Perimenopause "fear". I have done your hormone HRA + apart from feeling like I get TRIGGERED a lot easier, I don't have more of the common symptoms (ie night sweats). My cycle the last 2 months was slightly longer but don't want to over think it. I am wondering if there are bloods that can help outline where we are in terms of our hormones (I know saliva is preferable)... I really want to support my hormones, and know you say we can do this naturally well into later life ie 60's! I know estrogen declines + ED is common - would appreciate markers to look at, ranges + if your wife couldn't test what you'd recommend for her :) Thank you for ALL you do! Sienna       Rianna: Hi Dr. Cabral! Sleep it's an area I am REALLY focused on supporting - we know when we are tired everything is harder ;-) & I am all about energy as I move towards my mid-40's.. I track my sleep on Garmin + know you mention Deep Sleep (90 mins) + Rem Sleep (2+ hours) as ideals, but I am no where near there consistently. The only time I get quite close is during my detox. My HRV has improved considerably (almost doubled) since Jan(through substantially reducing alcohol intake + focusing on sleep hygiene). I average on 7 - 7.5 hours sleep, mostly right through or brief wake, + mostly feel great/rested. My REM sleep this morning was 0 minutes (??) - is that reall even possible? 80 mins deep, 6.5 hrs"light" - how much attention would you give it if you feel recharged? Tips? Thx for all you do!     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3782 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

This episode is brought to you by The Primal Skincare. Vascular surgeon Dr. Lily Johnston breaks down the definitive science of heart attack prevention and evaluates how modern diet and lifestyle choices directly accelerate or mitigate your cardiovascular risk. We explore the complex biological mechanisms underlying plaque formation and arterial rupture, moving beyond outdated dogmas to examine the real drivers of vascular disease: chronic inflammation, metabolic dysfunction, and the direct effects of insulin and glucose on your endothelial lining. Whether you are navigating the nuances of cholesterol management or looking for the most accurate diagnostic testing, this episode provides an authoritative, evidence-based roadmap to optimize your heart health and protect your arteries.In This Episode, We Reveal:The Pathophysiology of Plaque: How arterial plaque forms, why it ruptures, and the crucial clinical distinction between volatile soft plaque and stable calcified plaque.The Metabolic Drivers: The profound impact of chronic glucose and insulin elevation on arterial degradation.Advanced Diagnostics: Why standard lipid panels fail to show the whole picture, and how advanced imaging tools can detect early-stage disease.The Cholesterol Matrix: A scientific contextualization of LDL, the complexities of HDL, and whether elevated markers are a true risk factor on low-carbohydrate diets.Dietary Realities: A medical critique of common foods, the cardiovascular impact of processed ingredients, and the evidence supporting the Mediterranean diet.Scientific Resources & Dr. Johnston's Work:Dr. Lily Johnston (YouTube): https://www.youtube.com/@lilyjohnstonmdCleerly Health: https://cleerlyhealth.com/CardioRisk Ultrasound Testing: https://cardiorisk.com/HeartFlow CT Analysis: https://www.heartflow.com/

In this episode, preventive cardiologist Dr. Ann Marie Navar, a member of the committee that helped shape the American Heart Association's new recommendations for earlier cholesterol management, explains why many experts believe cardiovascular prevention should begin decades before most people ever experience symptoms. Dr. Navar explains why lowering LDL cholesterol earlier in life can have lasting benefits decades later, how ApoB and lipoprotein(a) are reshaping the way experts think about heart disease risk, and why some of the most popular fears surrounding statins aren't supported by the evidence. The conversation also explores the growing divide between evidence-based medicine and the wellness industry and the challenges of separating compelling biological theories from treatments that have actually been proven to improve health outcomes. She's a wealth of knowledge and a wonderful guest. Hope you enjoy.

Você otimizou o LDL. Chegou na meta de ApoB. E o paciente volta meses depois com um novo evento. Neste episódio especial, com apoio da Novo Nordisk, Diandro Mota e William Batah recebem o Dr. Eduardo Lima, doutor em Cardiologia pela USP, professor colaborador e supervisor da Residência em Cardiologia da FMUSP/InCor e Head Nacional de Cardiologia da Rede Américas, para uma conversa que pode redefinir como você enxerga o risco residual. A tese é direta: a aterosclerose nunca foi só uma doença de colesterol. Ela é imunometabólica, e a inflamação subclínica pode ser o elo que faltava.O que você vai aprender:

In this episode the guys break down the four biggest fitness traps of 2026 — over-reliance on wearables and tech, the GLP-1 shortcut and muscle loss crisis, chasing longevity fads over basics, and aesthetics over everything. They also get into the alien.gov website reveal (spoiler: not what anyone expected), the black market GLP-1 side hustle spreading through social circles, a new study showing resistance training beats cardio for fat loss head to head, and Doug's 30-day Dose liver enzyme experiment update. Then they coach live callers submitted through mplivecaller.com — Aidan from Kansas on lingering strength and nerve issues after mono, Jamie from Oklahoma on rebuilding her relationship with food and training after anorexia and overtraining, and Caleb from Pennsylvania who shares an inspiring 18-month reverse diet success story before getting help with chronic forearm pain. MAPS Summer Sale — https://mapsfitnessproducts.com Code: SUMMER40 — 40% off everything (programs, bundles, mods & guides) — June 1–14 only SPONSORS Vuori — https://vuoriclothing.com/mindpump 20% off first order — no code needed, automatically applied Dose (liver & cholesterol support) — https://dosedaily.co/MINDPUMP Code: MINDPUMP — 25% off first month subscription. Clinically backed, all-natural liquid supplement. Supports liver enzymes, LDL, HDL and skin health. Fatty15 (C15 essential fatty acid) — https://fatty15.com/MINDPUMP Code: MINDPUMP — additional 15% off the 90-day Starter Kit subscription. C15 has been shown to have 3x more cellular benefits than omega-3. LINKS Submit a live caller question: https://mplivecaller.com  Mind Pump Store: https://mindpumpstore.com  Maps Fitness Products: https://mapsfitnessproducts.com  Instagram: @mindpumpmedia 0:00 - Intro 2:12 - Fitness trap #1: Over-reliance on wearables and tech — when data becomes a stressor 8:21 - Fitness trap #2: GLP-1 and the muscle loss crisis — what nobody is telling you 16:36 - Fitness trap #3: Chasing longevity fads while ignoring the basics 20:56 - Fitness trap #4: Aesthetics over everything — why chasing the look kills the look 33:23 - Vuori — the random guy at the park who wouldn't stop complimenting Sal's joggers 44:57 - Resistance training vs. cardio for fat loss — new head to head study 47:57 - Dose liver supplement — skin benefits and Doug's 30-day cholesterol experiment 55:43 - Alien.gov — the government website reveal nobody saw coming 59:33 - Caller: Aidan (Kansas) — college swimmer, post-mono nerve issues, lost 100lbs on bench 1:13:13 - Caller: Jamie (Oklahoma) — anorexia history, overtraining, inner thigh pain, gets a coach 1:27:24 - Caller: Caleb (Pennsylvania) — 18-month reverse diet success story, now dealing with forearm pain  

Most of us have had that moment where we get our bloodwork back and shake our heads. We're still our active, health‑minded selves and out of nowhere—rising LDL, ApoB, A1C, and maybe blood pressure and Lp(a), too. This week, preventive cardiology dietitian Michelle Routhenstein joins us to unpack the cardiometabolic chaos and what's really driving it. She explains estrogen's protective role in lipids and blood pressure, why standard risk calculators and even calcium scores can miss women's disease, and which advanced labs are worth asking for. We also dig into how under‑fueling and low‑carb diets can worsen cardiometabolic health and plaque; why complex carbs, fiber, fermented foods, and gut health matter so much; and how to approach protein, red meat, electrolytes, nitric oxide, and statins in a personalized, empowering way—remembering that 80–90% of heart disease remains preventable when women get the right information and advocate for themselves.Michelle Routhenstein, MS, RD, CDCES, CDN is a preventive cardiology dietitian and founder of Entirely Nourished, a virtual practice focused on personalized, science-based nutrition for heart health. With over 14 years of experience, she helps people improve cardiometabolic risk and manage conditions like atherosclerosis, heart failure, and atrial fibrillation using a whole-person approach. She holds Bachelor's and Master's degrees in Clinical Nutrition from New York University, serves on the Forbes Health Advisory Board and the Medical Advisory Committee for the National Menopause Foundation, and is the author of The Truly Easy Heart-Healthy Cookbook and Simple Meal Solutions for High Blood Pressure. Her work has been featured in outlets including Forbes Health, Fox News, Prevention, Women's Health, and Good Housekeeping, and she works with clients virtually from New York via www.entirelynourished.comJoin us at Feisty Fest September 18-20, 2026: https://feisty.co/events/feisty-fest/Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Learn More about our 2026 Feisty Events, including Bike Camps and Cycling Trips: https://feisty.co/events/Follow Us on Instagram:Feisty Menopause: @feistymenopauseHit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 20% off your order with code FEISTYBRAIN at https://www.previnex.com/ Wahoo: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdrCozy Earth: Use Code HITPLAY at https://cozyearth.com/ for up to 20% off

Interest in macrocyclic peptides (MCPs) continues to grow, which means manufacturers are facing mounting pressure to develop production methods capable of supporting commercial-scale demand of these molecules. While they offer a unique combination of potency, selectivity, and drug-like properties, the structural complexity of MCPs has historically made them difficult and costly to manufacture using traditional peptide synthesis techniques. As a result, new manufacturing approaches are emerging that aim to improve efficiency, scalability, and sustainability while expanding access to this promising class of therapeutics. In this episode of Off Script, we spoke with David Thaisrivongs, executive director, head of biocatalysis at Merck, about research recently published in Science detailing a biocatalytic manufacturing process for enlicitide, an investigational oral macrocyclic peptide designed to lower LDL cholesterol. The conversation explores the limitations of conventional solid-phase peptide synthesis, how Merck leveraged enzyme-driven manufacturing and crystallization strategies to significantly reduce process complexity, and why minimizing chromatography can be critical for commercial-scale peptide production. He also discussed the broader implications of biocatalysis for manufacturing increasingly complex therapeutic modalities and how the technology could help shape the future of pharmaceutical production.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Dr. Spencer and Karl Nadolsky sit down with David W, a nurse practitioner and one of the actual patients enrolled in the Triumph 1 retatrutide phase 3 trial, to break down the data that was just presented at the American Diabetes Association conference and explain why everyone in obesity medicine is paying very close attention. In this episode they cover what retatrutide actually is and why adding glucagon agonism to the GLP-1 and GIP dual agonism of tirzepatide creates a meaningfully different drug with direct effects on liver lipid metabolism, insulin sensitivity, blood pressure, and fat catabolism that you do not see with semaglutide or tirzepatide alone, what David's personal experience in the 12 milligram arm looked like from dose escalation through steady state including the GI side effects that faded by month seven and the heartburn that a low dose PPI fixed quickly, how David went from 240 pounds and a BMI of 35 down to 167 pounds by the end of the trial representing roughly 30 percent weight loss which is right at the trial average, what the Triumph 1 obesity trial found at 80 weeks with the nine and 12 milligram doses delivering nearly 26 and 28 percent average weight loss respectively and almost half of patients on the highest dose losing 30 percent or more, why the 104 week extension data showing patients who stayed on 12 milligrams reaching 30.3 percent average weight loss is being compared to bariatric surgery outcomes, what the Transcend type 2 diabetes trial showed with average A1C dropping to 5.9 percent on the 12 milligram dose in patients who were on no other diabetes medication, why the 41 percent triglyceride reduction and 20 percent LDL reduction are particularly interesting given that the mechanism appears to involve multiple pathways in the liver that tirzepatide and semaglutide do not touch, what the 70 percent reduction in WOMAC knee arthritis pain scores and 60 percent reduction in sleep apnea events mean for patients who have been told their only option is surgery, how Spencer plans to use retatrutide clinically once it is approved and which patients he thinks are the right candidates, why the gray market research peptide version currently circulating is something both doctors strongly advise against, and what Triumph 2 and Triumph 3 are measuring and when that data is expected. The Docs Who Lift podcast distills and simplifies the complexities of exercise, medicine, and weight loss. Subscribe so you never miss an episode. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Wilner would love your feedback! Click here to send a text! Thanks!Many thanks to Dr. Bilal Ahmed for joining me on Episode #165 of The Art of Medicine with Dr. Andrew Wilner. Dr. Ahmed is a cardiologist and entrepreneur.We began our 30-minute conversation discussing his day-to-day work as a interventional and structural cardiologist, which required five years of fellowship training after completing his internal medicine residency. He was recently recruited to develop the structural cardiology program in Columbus, Georgia. The cardiac procedures that Dr. Bilal has been trained to do can be life-saving!In 2024, in his free time, Dr. Ahmed co-founded Lylah Health with his sister after recognizing a connection between cardiac health and the microbiome. He observed that a supplement containing prebiotics, probiotics, and postbiotics could lower LDL cholesterol by more than 20%—a result short of a high-intensity statin but comparable to some existing cholesterol-lowering medications. As a practicing cardiologist, he saw the potential health benefits for millions of people.Dr. Ahmed is also writing a book about his journey in medicine, his multigenerational family history, and the life lessons he hopes to share with his young daughter. To learn more, please go to: www.Lylahhealth.com#microbiome #hearthealth #cardiology #cardiologist @lylahhealth @bilalahmedPlease click "Fanmail" and share your feedback!If you enjoy an episode, please share with friends and colleagues. "The Art of Medicine with Dr. Andrew Wilner" is now available on Alexa! Just say, "Play podcast The Art of Medicine with Dr. Andrew Wilner!" To never miss a program, subscribe at www.andrewwilner.com. Follow me on Instagram: @andrewwilnermdX: @drwilnerlinkedin.com/in/drwilner Please rate and review each episode. To contact Dr. Wilner or to join the mailing list: www.andrewwilner.comThis production has been made possible in part by support from “The Art of Medicine's” wonderful sponsor, Locumstory.com, a resource where providers can get real, unbiased answers about locum tenens. If you are interested in locum tenens, or considering a new full-time position, please go to Locumstory.com.Or paste this link into your browser:https://locumstory.com/?source=DSP_directbuy_drwilnerpodcast...

This podcast is listener-supported. To receive new posts and support my work, consider becoming a free or paid subscriber.When we think about staying healthy, we naturally focus on daily habits like a balanced diet, exercise, and stress management. But there is a critical, often overlooked window into our body's internal workings that tells us exactly how those efforts are paying off: regular blood work.In this episode, I dive deep into the world of biomarkers and explore why tracking these numbers is the most powerful tool we have for detecting potential health issues before they ever show physical symptoms.I break down what is actually being measured in standard lipid and metabolic panels, debunk common misconceptions about “optimal” cholesterol levels, and look at the real-life numbers from my own recent blood work for reference. Whether you are curious about how a plant-based diet impacts your numbers or want to know which hidden tests you need to request at your next checkup, this episode serves as your comprehensive guide to owning your health.CAMBODIA 2027: Join me on an unforgettable journey from the breathtaking temples of Angkor to the vibrant streets of Phnom Penh. Join us for Culture, Cuisine & Conservation. Enter JOYFULVEGAN when booking to redeem the special offer of a one-on-one or private cooking class with me.In this episode we cover:* Why serious cardiovascular issues can develop silently without physical symptoms, and how early screening acts as a lifesaver* A simple “garbage truck” analogy to easily understand the differing roles of LDL and HDL cholesterol in your bloodstream* What clinical data reveals about the ideal total cholesterol threshold for eliminating heart attack risk* The chemical difference between animal-based saturated fats and plant-based options like coconut oil* The biological differences between Type 1 and Type 2 diabetes, and how to prevent insulin resistance naturally* How to meet your iron requirements effortlessly on a plant-based diet without unnecessary and dangerous supplementation* Key vitamins, minerals, and inflammation markers that are omitted from standard panels but are vital to request* A look at my own recent blood numbers and a personal story regarding hair thinning, perimenopause, zinc, and B12.

Dave Feldman is the originator of the Lipid Energy Model and the Lean Mass Hyper-Responder (LMHR) phenotype, reshaping how we understand cholesterol and metabolism. As founder of the Citizen Science Foundation, he leads groundbreaking research into lipid metabolism, cardiovascular health, and metabolic responses to ketogenic diets. Dave's work includes spearheading the Keto-CTA study, which investigates how diet influences plaque progression and regression using advanced imaging. A passionate advocate for open science, he engages with researchers, clinicians, and the public to challenge assumptions, foster transparency, and drive innovative, data-driven insights into cardiovascular risk and human metabolism. INSTAGRAM: https://www.instagram.com/realdavefeldman TWITTER / X: https://x.com/realdavefeldman LINKEDIN: https://www.linkedin.com/in/dave-feldman/ YOUTUBE: https://www.youtube.com/@realDaveFeldman https://www.youtube.com/@feldmanprotocol Timestamps: 00:00 Trailer 00:37 Introduction 05:36 Experimenting with diet and risk decisions 08:03 Understanding the lipidary model 11:26 Early lipid conference predictions 15:56 Discussing blood glucose in athletes 17:34 Triglyceride delivery issues 21:05 Experimenting with lipid energy models 23:29 Positive feedback on keto documentary 29:42 Discrepancies in data analysis 32:51 Paper retraction and investigation process 36:47 LDL and health studies 38:33 Analyzing plaque level accuracy 41:51 Study eligibility criteria 47:29 Rethinking study design choices 48:40 The lipid hypothesis study 52:11 Metabolic health improvements 54:21 Where to watch The Cholesterol Code documentary Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

Equip Foods grass-fed beef protein (20% off with Ben's link):  https://bit.ly/3RKCzhW — use code BENAZADI Pre-order Keto Flex Revised and get free bonuses: https://bit.ly/4wKG1sM    Ben Azadi spent 90 straight days eating nothing but beef, eggs, butter, salt, and organ meat. No vegetables, no fruit, no fiber, no carbs. Then he tested everything. His cholesterol numbers would have sent most doctors into a panic. His total cholesterol hit 434. His LDL hit 350. But when one of the world's top heart surgeons reviewed the full panel, the verdict was clear: his cardiovascular risk had actually improved. Then the gut results came in. After 90 days of zero plants and zero fiber, his gut microbiome diversity went up. Not down. Up. In this episode, Ben walks through everything: the adaptation period, the body composition changes, the full blood work breakdown with board-certified cardiothoracic surgeon Dr. Philip Ovadia, the gut microbiome reveal with Dr. Will DiPaolo and Dr. Daniel Pompa, and what the science actually says about cholesterol, red meat, and the human body. If you've ever been told that saturated fat will kill you, that LDL is the enemy, or that you need fiber to have a healthy gut, this episode will make you question all of it. Key takeaways: Lost 16 pounds and 6% body fat in 60 days Heart rate variability, sleep quality, and glucose all improved Triglyceride-to-HDL ratio hit 1.0, a marker of near-zero insulin resistance Gut diversity, keystone bacteria, and core bacteria all increased on zero plants LDL on its own is one of the worst predictors of actual cardiovascular risk Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we review key updates from the 2026 ACC-AHA Guidelines on the Management of Dyslipidemia. Key Concepts The PREVENT ASCVD equation is now recommended to calculate ASCVD risk, with thresholds at 3%, 5%, and 10%. The previous 7.5% threshold for statin treatment is now 5%. In addition to the 10-year ASCVD estimate, clinicians should consider the use of Lp(a), "risk enhancers", and coronary artery calcium (CAC) scans as a "tie breaker" with shared decision-making when the decision to treat is not clear. In addition to LDL goals of < 100, < 70, or < 55 (depending on risk), the new guidelines also suggest non-HDL-C and apoB goals once LDL cholesterol is at goal. Many patients will require non-statin therapies to achieve lipid goals. The recommended non-statin therapies include ezetimibe, PCSK9 mAb, PCSK9-interfering RNA, and bempedoic acid. References Writing Committee Members, Blumenthal RS, Morris PB, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276. doi:10.1161/CIR.0000000000001423 Wiggins BS, Barac A, Benziger CP, et al. 2026 Dyslipidemia Guideline-at-a-Glance. J Am Coll Cardiol. 2026;87(19):2617-2623. doi:10.1016/j.jacc.2026.02.4872 Superko H, Garrett B. Small Dense LDL: Scientific Background, Clinical Relevance, and Recent Evidence Still a Risk Even with 'Normal' LDL-C Levels. Biomedicines. 2022;10(4):829. Published 2022 Apr 1. doi:10.3390/biomedicines10040829

Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.

Are your daily habits negatively impacting your hormones and your overall health? And when it comes to hormones, are you focusing on only your sex hormones? It turns out other hormones are running the show! This episode breaks down common hormone dealbreakers and practical steps you can take to avoid them and reclaim your health.On this episode of Salad with a Side of Fries, host Jenn Trepeck is joined by Robin Nielsen, board-certified integrative nutritionist and founder of Natural Hormone Solution, to unpack the hidden hormone dealbreakers quietly sabotaging your health. From the real role of cortisol rhythm to the truth about cholesterol and sex hormones, xenoestrogens in your face cream, and why your to-do list is wrecking your endocrine system, this conversation is a masterclass in natural hormone balance for women at every stage of life.What You Will Learn in This Episode:✅ Why cortisol and insulin are your two most important hormones and how their dysregulation drives symptoms that are often misread as perimenopause or aging.✅ How environmental xenoestrogens found in face creams, shampoos, and household cleaners silently disrupt your estrogen balance and what to do about it.✅ The critical connection between eating for hormone balance, meal timing, and why skipping breakfast and over-exercising are two of the most damaging habits for women's hormonal health.✅ How cholesterol actually serves as the building block for all your steroid hormones, and why lowering it too aggressively may be making your symptoms worse.The Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Jenn introduces Robin Nielsen, founder of Natural Hormone Solution and integrative nutritionist04:57 Robin shares her personal story: decades of weight gain, cystic acne, and digestive health issues09:18 Why common symptoms are not normal: hormone imbalance signs you may be ignoring11:27 Your sex hormones aren't the only ones linked to your overall health and wellness15:41 Cortisol rhythm explained: how your brain responds to daily stress and excess cortisol21:14 Hormone dealbreaker one: how negative thoughts and low serotonin levels disrupt cortisol23:24 Hormone dealbreaker two: xenoestrogens, environmental toxins, and harmful body care products27:47 The importance of eating breakfast and the benefits of walking33:19 Discussion of cholesterol levels and balancing HDL and LDL numbers38:12 The surprising hormone dealbreaker hiding in plain sight: your to-do list and nervous system healthKEY TAKEAWAYS:

Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead. Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab. Sponsored by Igennus — visit igennus.com/drkahn for 20% off.

Text Dr. Black your questions or comments.Lowering your cholesterol doesn't have to mean overhauling your entire life. In this episode, I walk through how small, strategic food choices can make a meaningful difference in your numbers—and your long-term heart health.I focus on what actually moves the needle when it comes to lowering LDL cholesterol through diet. We break down the most effective evidence-based approaches, including key foods to increase, what to limit, and how to make these changes realistic for busy adults and families. I also introduce the concept of a “portfolio approach” to nutrition—layering small habits that work together to produce measurable results.Key Takeaways:Soluble fiber plays a major role in lowering LDL cholesterolPlant sterols and stanols can help block cholesterol absorptionSwapping saturated fats for unsaturated fats supports heart healthNuts, beans, and whole grains provide powerful, practical benefitsSmall, consistent changes are effective and sustainableLinks from episode:ACC/American Heart Association Issue Updated Guideline for Managing Lipids, Cholesterol Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive ProteinEating to Lower Cholesterol Recipes - recipes from my live presentation for San Marcos Life Long Learning.Simple Tips to Lower CholesterolIf you enjoyed this episode, please take a moment to rate it, leave a review, and most importantly, share it with a friend!Don't forget to visit the show website and subscribe!  For resources related to a plant-based diet or if you struggle to afford healthy food for your family, please go to eatgreenswithdrblack.com/resources.Did you know you can send me a Text? Just click the link at the top of the show notes. You can also email me at dr.black@eatgreenswithdrblack.com.I am happy to answer general questions related to the information presented on this podcast.  Be advised that I will never offer specific medical advice via this website, even if your child is an established patient in my practice. If you have concerns about your child's health or growth, please contact their doctor.Thanks for listening and don't forget to Eat Your Greens!

A quarter of US adults have elevated levels of LDL, the type of cholesterol in the blood most often associated with atherosclerosis and cardiovascular disease. Now the American College of Cardiology has issued new guidelines for managing cholesterol, last updated … New guidelines from the American College of Cardiology for cholesterol guidelines are here, Elizabeth Tracey reports Read More »

If you've been told you have high LDL cholesterol in your blood, the first place to begin to try to improve it is with diet and exercise. That's according to new guidelines from the American College of Cardiology, and such … The first strategy to improve blood cholesterol levels in lifestyle management, Elizabeth Tracey reports Read More »

When it comes to ideal LDL cholesterol levels in the blood, ideal is a bit of a moving target. Johns Hopkins cardiologist Roger Blumenthal, chair of an American College of Cardiology committee that has just updated cholesterol guidelines, says it … What LDL cholesterol level should you be aiming for? Elizabeth Tracey reports Read More »

For years, cholesterol numbers have been treated as one of the primary indicators of heart health, but are we focusing on the right markers? In this episode, I sit down with Dr. Terri DeNeui to discuss the bigger picture behind cardiovascular risk. We talk through the limitations of looking at LDL cholesterol in isolation, the importance of factors like inflammation, insulin resistance, ApoB, lipoprotein(a), calcium scores, and lifestyle habits, and why a more comprehensive assessment may be necessary before deciding on treatment options. We also discuss the role statins can play, who may benefit from them, and why individualized care matters when evaluating cardiovascular health.  We also explore the connection between hormones and metabolic health. Dr. DeNeui explains how changes in estrogen, progesterone, and testosterone can influence cholesterol, blood pressure, body composition, and overall wellbeing. Topics We Cover in This Episode:  Why cholesterol numbers rarely tell the whole story The cardiovascular markers many people have never heard of What calcium scores can and cannot tell you How insulin resistance often shows up long before diabetes The relationship between menopause, hormones, and changing cholesterol levels Why gut health keeps showing up in conversations about chronic disease The role estrogen plays in men's health and performance Questions worth asking when evaluating your long-term cardiovascular risk Whether you're trying to better understand your own lab work, navigate conversations about statins, or learn more about the connection between hormones and overall health, this episode offers a thoughtful discussion on some of today's most debated topics in preventive medicine. Join us as we explore the factors that may matter most when it comes to supporting long-term health and making informed decisions about your care. Resources & Links

Tim Conway Jr Show Hour 4 (5.29) Conway kicks off the hour with a look at two promising new cholesterol treatments, enlicitide and VERVE-102, both aiming to help lower LDL “bad” cholesterol — but in completely different ways. One sounds like the future of medicine, and the other sounds like Conway is ready to gamble on it like a casino bet. Then the crew dives into the viral Trader Joe’s Sweet & Sour Gummy Worms story. These innocent-looking candies are loaded with fiber, and because the bag doesn’t exactly scream “high fiber warning,” some shoppers are eating way too many and ending up with stomach rumbling, gas, and a surprise bathroom emergency. The ultimate buzzkill candy. Later, Conway tells his Egg McMuffin story after going 35 years without one, explains how he managed to annoy a pharmacist at CVS, and breaks down the chaos of picking up everyone’s Starbucks drinks. The hour wraps with one of the strangest side hustle stories yet: a 23-year-old creator making serious money selling videos of herself farting. Forget Etsy, rideshare, and vintage clothes — this is the new economy, and Conway has questions. cholesterol treatment, LDL cholesterol, VERVE-102, enlicitide, Trader Joe’s gummies, Sweet & Sour Gummy Worms, high fiber candy, bathroom emergency, Egg McMuffin, CVS pharmacy, Starbucks order, weird side hustle, fart videos, viral story, funny podcast, Conway Show See omnystudio.com/listener for privacy information.

A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Permanent Lipid Lowering therapy Verve 102 Therapy for FH https://www.nejm.org/doi/full/10.1056/NEJMoa2601283 II Vesalius Substudy on PCSK9i Use in Patients With Previous PCI VESALIUS Subgroup Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080616 VESALIUS Study - NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2514428 III Tirzepatide looking to be best again SURPASS-EARLY Trial https://www.acpjournals.org/doi/10.7326/ANNALS-25-05602 SURMOUNT-5 Trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2416394 IV Arrhythmias in Cardiac Amyloidosis Loop Recorders Reveal Arrhythmias in Cardiac Amyloidosis https://www.medscape.com/viewarticle/loop-recorders-reveal-arrhythmias-cardiac-amyloidosis-2026a1000gq9 EXCALIBUR Study https://www.jacc.org/doi/10.1016/j.jacc.2026.04.030 V Lipid Guidelines ·       In Defense of the 2026 Dyslipidemia Guideline https://www.medscape.com/viewarticle/defense-2026-dyslipidemia-guideline-2026a1000hd0 Lipid Guidelines: Four Major Concerns https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

May 29, 2026: Your daily rundown of health and wellness news, in under 5 minutes. Today's top stories: Noom launches at-home biomarker kits measuring 17 markers with microneedle collection, finding 70% of users have high LDL cholesterol despite appearing healthy Scientists report single gene-editing infusion lowering LDL cholesterol by 62% with results maintained 18+ months, potentially replacing years of daily medication Retro Biosciences reaches $1.8B valuation backed by Sam Altman, entering human trials testing cellular cleanup process to combat neurodegeneration and age-related disease More from Fitt: Fitt Insider breaks down the convergence of fitness, wellness, and healthcare — and what it means for business, culture, and capital. Subscribe to our newsletter → insider.fitt.co/subscribe Work with our recruiting firm → https://talent.fitt.co/ Follow us on Instagram → https://www.instagram.com/fittinsider/ Follow us on LinkedIn → linkedin.com/company/fittinsider Reach out → insider@fitt.co

Eat this every single day to help prevent clogged arteries and support heart health. Focus on heart attack prevention by addressing the real cause of artery plaque buildup in the first place.

Ring lights make us irrationally angry, and somehow that turns into a full-blown deep dive on coffee science, coffee myths, and why the internet can't stop being weird about both. We're joined by Han (Son Of Han Coffee), and what starts as a sponsor shout-out quickly becomes the kind of practical coffee talk we wish more people had: how roast level changes flavor, why “I hate coffee” often means “I've only had burnt dark roast,” and what actually makes a bag of beans worth the price.We get into the real-life upgrades that matter for better coffee at home: buying whole bean coffee instead of pre-ground, grinding fresh to protect aroma, and choosing a brew method you'll actually stick with. Pour over, French press, drip, espresso, siphon coffee makers that look like a chemistry set, even the water temperature you use all change extraction and flavor. We also unpack the myths that keep spreading, including “coffee dehydrates you” (it doesn't for most people), what polyphenols might have to do with coffee benefits, and why unfiltered coffee can include diterpenes that may affect LDL cholesterol for some folks.Then, because we can't help ourselves, we detour into decaf methods like Swiss Water Process and CO2 decaf, tea vs tisanes, DeLorean time-travel bits, and the gym community buying horse electrolytes because the bucket is cheap. If you like smart tangents, honest takes, and actionable coffee advice without the snob act, hit play. Subscribe, share this with a fellow coffee nerd, and leave a review with your go-to brew method. Support the showYou can find us on social media here:Rob TiktokRob InstagramLiam TiktokLiam Instagram

Send us Fan MailDeep-dive into a 2026 cardiology review paper claiming seed oils reduce inflammation, exposing misrepresentations of cited clinical trials, and detailing how oxidized Ω-6 fats trigger inflammation.Companion article: Click HERETOPICS DISCUSSED:Seed Oil Profiles: Typical seed oils like sunflower are high in linoleic acid (omega-6 PUFA), while canola is higher in monounsaturated fats and resembles olive oil.Review Paper Critique: The 2026 JACC review falsely claims sunflower oil reduce inflammation like olive oil, citing an RCT that showed benefits only for canola and olive.RCT Analysis: In Iranian women with metabolic issues, switching to canola or olive oil lowered CRP by increasing MUFA and decreasing PUFA intake; sunflower oil produced no change.CRP Biology: CRP responds to oxidized lipids and cellular damage patterns, rising with exercise or infection and marking oxidized Ω-6 metabolites in modern diets.Oxidized Lipids: Ω-6 fats in LDL and cardiolipin oxidize easily, generating 4-HNE, MDA, and other signals that trigger immune clearance, similar to bacterial threats.Sterile Inflammation: High dietary linoleic acid causes chronic immune activation without pathogens, potentially contributing to metabolic and cardiovascular issues.PRACTICAL TAKEAWAYS:Prioritize monounsaturated fats from olive or avocado oil over high-linoleic seed oils like standard sunflower or soybean for lower oxidative stress potential.Check labels for high-oleic versions of sunflower oil, which shift the profile toward monounsaturated fats.Evaluate nutrition claims by examining original studies and fatty acid compositions rather than accepting review summaries at face value.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Andrew, Ben, and Tom discuss the reported two-phase US-Iran deal to reopen the Strait of Hormuz and dispose of enriched uranium, market reactions with oil dropping to the low $90s and the 10-year falling to 4.50%, Kevin Warsh's first comments as Fed Chair signaling reform, the WSJ piece on the vanishing equity risk premium, and Eli Lilly's VERVE-102 one-shot gene editing therapy showing up to 62% LDL cholesterol reduction in early trials as a potential challenger to Amgen's Repatha.Join our live YouTube stream Monday through Friday at 8:30 AM EST:http://www.youtube.com/@TheMorningMarketBriefingPlease see disclosures:https://www.narwhal.com/disclosure

Adam talks with American journalist Patrick Radden Keefe about his book London Falling: A Mysterious Death in a Gilded City and a Family's Search for Truth, the challenges presented by parenting adolescents, the seductive power of movies like The Wolf Of Wall Street and Patrick's own efforts to resist the glamorising effect of TV and film during production of the TV adaptation of his book about the Troubles in Northern Ireland, Say Nothing, and Adam's own ludicrous taste of the criminal life in his early adolescence. There's also chat about why David Byrne's live show was the best live music show Adam has ever seen and whether it's OK to stand up at a seated music show.Conversation recorded face-to-face in Bath on 7 May, 2026LONDON FALLING by Patrick Radden Keefe - 2026 (Waterstones)CLARIFICATION RE. STATINS vs GLP-1sResponding to Adam's comments about statins at the end of the conversation with Patrick, this was sent in by Dr Mit Shah, MBBS BSc (Hons) PhD, Consultant Cardiologist in Preventive Cardiology, Harefield Hospital:I'm a consultant cardiologist specialising in lipid disorders and preventive cardiology. While both GLP-1 drugs and statins can reduce cardiovascular risk, they work through very different mechanisms and treat different underlying problems. Statins are specifically used to lower LDL cholesterol, whereas GLP-1 drugs mainly work through the blood glucose and weight-loss pathway, with only modest effects on cholesterol.Statins have become somewhat unfairly maligned through widespread misinformation and exaggerated claims about side effects, despite very strong clinical evidence for benefit. In fact, researchers have even performed randomised trials demonstrating a significant “nocebo effect”, where patients experience expected side effects even when taking placebo tablets due to their preconceived expectations and worries. Daily, I see patients with severe (sometimes genetic) cholesterol disorders who have a critical need for statin therapy, but who are understandably hesitant because of what they've heard online. I worry that the idea that GLP-1s could simply replace statins may unintentionally add to that confusion.SUBMIT QUESTIONS FOR Q&A EPISODE: Adambuxtonpodcast@gmail.comThanks to Diggory Waite and Claire Broughton at Hattrick and Séamus Murphy Mitchell for production support.Podcast illustration by Helen GreenSPONSOR: SAILY

Show Notes: Lilly Minkove shares her background in brand and strategy consulting, focusing on retail, beauty, and wellness. She discusses her time at McKinsey, Tapestry, and Louis Vuitton, emphasizing her work in the luxury sector. Lilly explains her transition from the corporate world to running ArtLogica Group, a boutique consulting practice focused on customer insights. Introduction to HeraSphere Lilly talks about her interest in health and wellness, which eclipsed her work in retail and luxury. She recounts attending a longevity talk by Dr. Darshan Shah, which sparked her interest in tracking biomarkers and consumer insights. Lilly describes the inception of HeraSphere, a women's health newsletter translating healthcare innovations into plain English. She highlights the importance of women's health, especially for those in perimenopause or menopause, and how her consulting experience translates to this new focus. The Five Pillars of Health Lilly outlines the five pillars of health: exercise and muscle, sleep, nutrition, brain health, and connection. She emphasizes the importance of strength training, noting that muscle is an anti-aging metabolic organ. She discusses the benefits of muscle, including anti-inflammatory proteins, insulin resistance, and bone density protection. The Critical Role of Sleep Lilly explains the critical role of sleep in brain function, immune system, and overall health. She discusses the importance of regularity and quality of sleep, noting that even one night of sleep deprivation can significantly impact natural killer cell activity. Lilly shares tips for improving sleep quality, such as maintaining a consistent sleep schedule, avoiding alcohol, and using a sleep tracker. The conversation turns to the impact of stress and anxiety on sleep and the importance of winding down before bed. The Impact of Sugar on the Body Lilly highlights the negative effects of sugar on the body, including inflammation, cardiovascular disease, and diabetes. She explains the concept of glucose spikes and how eating fiber, protein, and fat before carbohydrates can reduce their impact. Lilly emphasizes the importance of a diverse diet, recommending consuming 30 different types of plants and vegetables weekly and highlights the challenges of hidden sugars in processed foods. Maintaining Brain Health Lilly discusses the significance of brain health, noting that the brain consumes 20% of daily calories and requires continuous stimulation. She shares her experience with learning a new skill, cardio dance, and how it improves muscle memory and cognitive function. Lilly explains the link between midlife decisions and cognitive outcomes, emphasizing the importance of lifestyle measures in preventing Alzheimer's. Lilly elaborates on the benefits of keeping the brain active through learning and new skills. Community and Health Connection Lilly highlights the importance of social connections for overall health, citing a Harvard study on the mortality risk of social isolation. She discusses the decline of extended family households and the need for intentional efforts to maintain social connections. Lilly emphasizes the role of small interactions with people in the community in reducing loneliness and improving well-being. Lilly discusses the benefits of having a support system and the impact of feeling less isolated on health outcomes. The Complexity of the Wellness Industry Lilly explains her dual objectives: sharing knowledge with consumers and using consumer insights to inform her consulting practice. She offers services to help brands distill what their customers want and convey value effectively. Lilly highlights the complexity of the wellness industry and her expertise in understanding the female consumer. Measuring Health KPIs Lilly outlines key health metrics, starting with blood pressure and hemoglobin A1C, which measure metabolic efficiency and cardiovascular risk. She discusses C-reactive protein (CRP) as an indicator of systemic inflammation and its association with various diseases. Lilly explains fasting insulin and LDL cholesterol, noting their importance in measuring insulin resistance and cardiovascular health. She highlights the importance of bone density and body composition, recommending DEXA scans for accurate measurement. A Focus on Longevity Lilly discusses VO2 max, a measure of cardiovascular capacity and longevity, and the challenges of obtaining accurate measurements. She mentions the use of fitness trackers to estimate VO2 max and the benefits of regular monitoring. Lilly shares her personal practice of conducting twice-yearly health panels to track biomarkers and ensure overall well-being. Timestamps: 02:47: Transition to Women's Health and HeraSphere  06:48: Key Health Pillars: Exercise and Muscle  13:57: Sleep and Its Importance  23:57: Nutrition and Sugar Impact  29:53: Brain Health and Lifelong Learning  36:20: Connection and Social Support  38:32: Lilly's Services and Consumer Insights  41:08: Key Performance Indicators (KPIs) for Health  47:04: Advanced Health Metrics and Longevity  Links:  HeraSphere newsletter: https://herasphere.beehiiv.com/ HeraSphere website: https://herasphere.beehiiv.com/p/herasphere-24-become-the-ceo-of-your-health Consulting practice website: https://artlogicagroup.com/ This episode on Umbrex:    Unleashed is produced by Umbrex, which has a mission of connecting independent management consultants with one another, creating opportunities for members to meet, build relationships, and share lessons learned. Learn more at www.umbrex.com. *AI generated timestamps and show notes.  

Text Dr. Lenz any feedback or questions The 2026 Cholesterol Revolution: PREVENT Scores, Hidden Risk Markers, and CAC ScansThe script explains how 2026 ACC/AHA guideline changes aim to make heart attacks more preventable by shifting from short-term “10-year risk” thinking to “lower for longer,” precision prevention, and primordial prevention starting earlier in life. It critiques the older Pooled Cohort Equations for underestimating risk in younger people and introduces the PREVENT equation, which adds 30-year risk plus kidney, metabolic, and social factors. It highlights lipoprotein(a) as a largely genetic once-in-a-lifetime test and hs-CRP as an inflammation marker, and emphasizes coronary artery calcium (CAC) scoring as a tiebreaker for statin decisions (0, 1–99, ≥100). Cases illustrate these tools, including tighter LDL goals (

What if you could detect Alzheimer's years before any symptoms appeared and stop it?Dr. Yogesh Shah is a Board-Certified Geriatrician and Mayo Clinic-trained memory specialist who has spent 25 years focused entirely on the early detection and prevention of dementia. In this episode, he makes a case that every entrepreneur in their 40s and 50s needs to hear: the window to protect your brain is now. Not at 70. Not after a diagnosis.America spends 20% of its GDP on healthcare, and nearly all of it goes to disease management. Dr. Shah explains why that approach is failing, what Mild Cognitive Impairment is and why it matters, and how a new FDA-approved blood test can identify Alzheimer's pathology years before any symptoms appear. He walks through the 14 lifestyle factors identified in the Lancet study that can reduce dementia risk by up to 45%, and explains how monoclonal antibody infusions are now removing amyloid plaque from the brains of patients caught early enough.What you will walk away with: an understanding of why 40 to 50% of dementia cases go undiagnosed and the real-world consequences, what the new p-tau blood tests are and how to ask your doctor about getting one, which lifestyle factors carry the most risk weight for entrepreneurs, and why managing your LDL, sleep, social connection, and chronic conditions in midlife is the most important thing you can do for your future brain health.Connect with Dr. Yogesh Shah on LinkedIn Hosted by John St. Pierre and Rich Hoffmann, Entrepreneurs United is built for founders and leaders who want straight talk on building businesses that actually work. New episodes every week.https://entrepreneursunited.us/links/

Are you lean, exercising and eating right, but yet, your cholesterol shows a different story? Maybe it's super high and you cant explain why? So, high cholesterol may not always be a problem… and we actually may be over-treating numbers and missing what what actually drive heart disease.  We cover: Why high LDL doesn't always mean high risk The real role of statins vs newer medications and if and when to use them How genetics, diet, and metabolism change cholesterol response What actually improves cardiovascular health (beyond labs) The surprising tools you never heard of that may support vascular function   Trained in conventional cardiology, Dr. Husain recognized early the limits of reactive medicine. That insight led him to pursue advanced training in preventive, functional, hormonal, and cellular-based therapies, integrating these disciplines into a deeply individualized approach to cardiovascular care. Beyond the clinic, he serves as an educator and scientific advisor, helping clinicians and organizations rethink how we assess cardiovascular risk, resilience, and overall long-term health. He is also a multi-sport athlete, artist, and lifelong learner, because he believes true health is not just measured in years lived, but in vitality, creativity, and meaning. Available to see new patients at Boulder Longevity Institute: https://boulderlongevity.com/about Upcoming Vascular medicine & Cardiology Health course for practitioners available at Next Generation Medicine https://www.nextgenerationmedicine.co/ Contact Dr. Abid Husain Instagram: @dr_abidhusain Facebook: @abid.husain.7712 LinkedIn: www.linkedin.com/in/abid-husain-md-facc-abaarm-00874419 Youtube: https://www.youtube.com/@DoctorAbidHusain Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here - https://vitaliskincare.com Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - https://www.oxfordhealthspan.com/ZORA Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try MitoQ for optimal mitochondrial health. Code ZORA for 20% off https://mitoq.com/zora   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠     Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠   Biohacking Menopause Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠    For partnership inquiries: https://www.category3.ca/  Some episodes of Hack My Age are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Ann: Hi Dr. Cabral! If no one has told you today you are making a huge difference in the world :). Thank you . My Apo-a is 35.5, and my cardiologist said that I could take a B Complex and that would help lower it. I know you cant give any medical advice, but I know in the past I have head you say its genetic so I was wondering if it was you or your family would you take Activated B Complex to try to lower your Apo-a? By the way- I started taking Proteolytic Enzymes with out changes in my (generally good) diet and exercise, and my LDL went down about 15% even though my cardiologist said supplements like that dissolve in the stomach and would never make it to where they need to to work.... Another reason we all trust your advice ! Thanks again have a great day!      Sarah: I've been dealing with gut issues for about five years, mainly bloating. I suspected gluten might be a factor, so I had testing done. My bloodwork showed I carry the celiac gene, but I tested negative for celiac, and an endoscopy also confirmed no celiac disease. However, both of my children have been diagnosed with celiac—one has symptoms and the other is asymptomatic. I recently discovered your gluten/dairy digestive enzyme and was wondering—would it be okay to take something like that before eating gluten? Or should I be avoiding gluten altogether just in case I could still have celiac or develop it? I'm also assuming that people with confirmed celiac shouldn't take gluten enzymes and instead need to strictly avoid gluten. Just looking for some guidance, thank you!      Sherrie: Good day Mr. Cabral, First off thanks for changing mine and my families lives! I was wondering whats the best route to take if you have black/bags under your eyes and you are a 33 year old female? It happens quite often and I was wondering what I should to do fix it? I am assuming running one of the labs first and going from there but which one should I take and what is some general guidelines to help with the issue. Thanks again for always having advice/guidance.      Mitchell: Hi Dr Cabral! My sister who is 26 recently got diagnosed with Primary sclerosing cholangitis. They told her that it is untreatable but we know that they claim that about a lot of treatable diseases. What advice/protocols/nutrition and supplements would you give to your sister to help tackle this disgnosis? Any help is appreciated, thanks!       Summer: Hi Dr. Cabral! I wrote in a few months ago about what I thought was a cherry angioma, but mentioned it was growing rapidly despite trying a number of ways to remove it myself…  I finally reluctantly went to the dermatologist after you and my practitioner suggested it and found out it was a benign pyogenic granuloma. It was removed very quickly and easily. I researched a bit myself, but I'm curious what causes them in your opinion and how to avoid more? I do have a handful of small cherry angioma's. I wonder if the two are connected somehow? I'm a 36 year old female and stay on top of my health with seasonal detoxes, Mediterranean diet, and a healthy mindful lifestyle. Thanks for all you do! I love being able to ask you questions and follow-ups anytime they pop up! Many blessings to you!      Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3760 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Robert C. Smith is best known for arguing medicine lost its mind. This episode he explains why he is still proud to be a doctor. Primary care physicians deliver 75 percent of the nation's mental health care without training for it, and Smith has spent his career trying to fix that. But before the fix, he makes a case that may surprise his own readers: modern medicine has been astonishingly effective at what it was built to do. This episode is based on his article "How the mind-body split in medicine shaped modern clinical care," published on KevinMD. You will hear how 2,500 years of four humors and bloodletting gave way to a physical-disease framework that doubled life expectancy from 40 to 80. You will also learn why that same framework now leaves psychiatry stalled. Hear why the reformer who wants to overhaul mental health care still says medicine has never been better at the thing it was built to do. Tune into our episode "2026 Cholesterol Guidelines: LDL goals, lipoprotein(a), and coronary calcium scoring," brought to you by Novartis Pharmaceuticals Corporation. For the first time in eight years, LDL cholesterol goals have changed, and preventive cardiologist Seth Baum says the new guidelines are a long-overdue course correction. He breaks down the new LDL targets for your highest-risk patients, why the LDL hypothesis should be retired in favor of the LDL fact, why lipoprotein(a) screening finally belongs in every patient's workup, what a coronary calcium score over 300 really means for how aggressively you treat, and how to talk to statin-skeptical patients without losing their trust. Listen now at KevinMD.com/cholesterol. VISIT SPONSOR → https://kevinmd.com/cholesterol Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

What happens when almost 500 firefighters get a full health screening—and many discover hidden risks they never saw coming?Rip sits down with Deputy Chief Jayme McConnellogue and Lieutenant Ian Elliott of the Colorado Springs Fire Department to explore a groundbreaking department-wide health initiative—and the life-changing results.From undiagnosed cancers to widespread cardiovascular risk, the findings were shocking. But what followed is even more inspiring: a grassroots movement toward better health, fueled by education, vulnerability, and the power of plant-based nutrition.Ian shares his personal story—from elite endurance athlete to unexpected heart health scare—and how a whole-food, plant-based lifestyle transformed his health, energy, and outlook.This episode is a must-listen for anyone who believes they're “doing everything right”… and for anyone ready to take control of their health.Key Takeaways:Nearly 500 firefighters voluntarily underwent health screeningsMultiple cancers identified—many in asymptomatic individuals84% had elevated LDL cholesterol (major heart disease risk)Over 50% had high total cholesterolHundreds of firefighters showed signs of hypertensionMental health culture paved the way for physical health transformationReal change started from the ground up—not top downFood can be a powerful tool for prevention—and reversalYou'll Learn:Why even “fit” individuals can have hidden cardiovascular diseaseHow firehouse culture influences long-term healthThe connection between vulnerability and real behavior changeWhy plant-based nutrition is gaining traction—even in high-performance professionsHow to start making changes without overwhelmThis episode is really about leadership. It's about culture change. It's about vulnerability. And ultimately—it's about the life-saving power of the food we choose to put into our bodies every single day.Watch the Episode on YouTubeLearn More About our 2026 Live PLANTSTRONG Events: https://plantstrongevents.com/ Let Us Help Your PLANTSTRONG JourneyLearn More About Our Corporate Wellness Program: https://liveplantstrong.com/corporate-wellness/ COMPLEMENT: Use code PLANTSTRONG for 30% off at https://lovecomplement.com/pages/plantstrong-special-offer Follow PLANTSTRONG and Rip Esselstynhttps://plantstrong.com/ https://www.facebook.com/GoPlantstrong https://www.instagram.com/goplantstrong/https://www.instagram.com/ripesselstyn/ Follow the PLANTSTRONG Podcast and Give the Show a 5-star RatingApple PodcastsSpotify

Get personalized root-cause care with Empower Functional Health.Learn more at empowerfunctionalhealth.com_____Dr. Gary Fettke and I dive into the real drivers of modern disease: sugar, processed carbohydrates, and seed oils, and which of the three is doing the most damage. We break down the biochemistry of fructose, the polyol pathway, and how LDL particles are affected by diet. We also get into the origins of fat shaming, how pharmaceutical companies shaped public language around obesity, the fiber myth, and why cholesterol is wildly misunderstood. Make sure to listen to the full interview to learn more.Dr. Gary Fettke is a retired orthopedic surgeon and one of the earliest and most vocal proponents of low-carb, ketogenic, and carnivore nutrition in Australia. He was among the first in the world to describe the combination of sugar, refined carbohydrates, and seed oils as a nutritional model of inflammation and modern disease, a framework he developed back in 2013. Despite being investigated by the Australian medical board for his dietary advocacy, he has continued to push for change in national nutrition policy, helping make low-carb the nationally recognized strategy for diabetes management in Australia. He works alongside his wife Belinda Fettke, whose research tracks the ideological and corporate forces driving flawed dietary guidelines.We discuss the following:Dr. Fettke's background and updateSugar, carbs, and seed oils explainedThe polyol pathway and fructose overflowSeed oil half-life and inflammationReal-world cases and MS recoveryThe biggest dietary culpritObesity stigma and pharma influenceCholesterol, LDL particles, and statinsLipid subfractions and cardiac riskThe dietary evolutionNo biochemical need for ingested carbs_____EPISODE RESOURCESDr. Gary Fettke on YouTubeDr. Gary Fettke's Website Advanced Cardiovascular Health PanelUnveiling the Corruption of Our Dietary Recommendations - Interview with Dr. Gary FettkeThe Trouble with Fructose -  Interview with Dr. Gary FettkeExposing the Secrets of the Plant-Based Vegetarian Guidelines Interview with Belinda FettkeHow Kibble Can Be From Condemned Meat. Truth About Pet Food Interview with Susan Thixton_____WEEKLY NEWSLETTER 

A federal agency recognized food allergy as a disability, then limited boarding protection to one allergen category. Lianne Mandelbaum, a leading advocate for airline safety measures to protect food-allergic passengers, returns to explain how the March 2026 DOT ruling created a hierarchy within a single medical condition, leaving passengers with egg, sesame, milk, shellfish, and wheat allergies without the same pre-boarding rights granted to those with peanut and tree nut allergies. This episode is based on her article "How the new DOT ruling on food allergies threatens air travel safety," published on KevinMD. You will hear about a Southwest captain who removed a passenger for asking to pre-board with a pistachio allergy, an allergen that is covered under the new ruling. You will also hear why a Northwestern survey of 4,704 food-allergic travelers found that 98 percent experience flight anxiety and 70 percent were promised accommodations that never arrived. Hear why the guest says this ruling cements airline inconsistency as federal policy, and what physicians can do to push back. Tune into our episode "2026 Cholesterol Guidelines: LDL goals, lipoprotein(a), and coronary calcium scoring," brought to you by Novartis Pharmaceuticals Corporation. For the first time in eight years, LDL cholesterol goals have changed, and preventive cardiologist Seth Baum says the new guidelines are a long-overdue course correction. He breaks down the new LDL targets for your highest-risk patients, why the LDL hypothesis should be retired in favor of the LDL fact, why lipoprotein(a) screening finally belongs in every patient's workup, what a coronary calcium score over 300 really means for how aggressively you treat, and how to talk to statin-skeptical patients without losing their trust. Listen now at KevinMD.com/cholesterol. VISIT SPONSOR → https://kevinmd.com/cholesterol Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

What happens to your body and clinical judgment when you're managing a code blue at the exact hour your biology demands deep sleep? Chinyelu E. Oraedu is an academic hospitalist and nocturnist with 17 years of post-residency experience who has dedicated her career to understanding the science and human reality of night shift medicine. In this episode, based on her KevinMD article "How night shift medicine exposes the reality of physician stress," she breaks down why the 2 to 3 a.m. window is the most dangerous period for both patients and providers, when melatonin peaks, alertness bottoms out, and emergencies keep coming. You will learn practical strategies for surviving and thriving on night shift, from the right timing for caffeine intake to using light therapy at your workstation to suppress melatonin secretion. Oraedu explains why sleep is the single most important factor for night shift workers and why she tells every resident to protect it above exercise, meals, and everything else. She also shares surprising early data from her own research showing that night shift workers who build intentional structure around their schedule report high satisfaction. Whether you are an incoming intern about to start your first night float rotation or a seasoned nocturnist still battling fragmented sleep, this conversation offers a practical framework for reducing the hidden health risks of working against your circadian rhythm. Tune into our episode "2026 Cholesterol Guidelines: LDL goals, lipoprotein(a), and coronary calcium scoring," brought to you by Novartis Pharmaceuticals Corporation. For the first time in eight years, LDL cholesterol goals have changed, and preventive cardiologist Seth Baum says the new guidelines are a long-overdue course correction. He breaks down the new LDL targets for your highest-risk patients, why the LDL hypothesis should be retired in favor of the LDL fact, why lipoprotein(a) screening finally belongs in every patient's workup, what a coronary calcium score over 300 really means for how aggressively you treat, and how to talk to statin-skeptical patients without losing their trust. Listen now at KevinMD.com/cholesterol. VISIT SPONSOR → https://kevinmd.com/cholesterol Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Lauren: Hi Dr. Cabral, Thank you for all you do! I am grateful for all of the helpful information you share and your excellent supplements. I've been taking Advanced cell force for a couple of months. It's really the only new product I've been taking and after 6 years at the same Armour Thyroid dose of 60mg, my thyroid is overactive and my Naturopath has reduced my dose to 30mg. I'm getting levels retested Monday, so I'm curious to see what's going on. I was diagnosed with hashimotos in my early 20s but didn't need thryoid meds until 33 years old (now 43). Just seems interesting that after so long at the same dose, my thyroid is now functioning better. I'm grateful, just curious. Thanks again!      Denise: If toxins can be stored in fat cells and GLP 1's cause rapid weight loss, what happens to the toxins? Are they released from the body with the fat or are they let loose in the body to find a new place to hide? Does taking a GLP 1 help with stored toxins or cause more harm? And how do GLP 1's affect oxidative stress. Help or harm?      Tricia: Hi Dr. Cabral - Hope you are having a great day! Quick question on your sleep supplements. I'm 56 and thought I would start taking Melatonin. My sleep is not horrible but not as good as when I was younger. I noticed your Sleep Support supplement has Melatonin in it already. When would I use this supplement over Melatonin alone? I don't take Adrenal Soothe because I take Metavolve pm which I thought that might be double dosing of some     Mohamed: Hello Dr.Cabral, really enjoy your videos. The information you provide and your experience is invaluable. Thanks for all that you do for the entire community. My question is 2 part. Firstly regarding L-lysine and HSV/cold sores. I watched your older podcast on the topic.. but is there a recommended daily dose for Lysine? Second question is regarding Mouth-taping. How can I prep to clear my sinuses. A bit nervous. Would sinus support Equilife product help?      Larissa: Hello Dr Cabral, Thank you for all that you do and your wonderful advice! I have yet another question about cholesterol. I feel very conflicted about LDL cholesterol after reading a 2024 study regarding the lipid energy model. It suggested that high LDL levels in "Lean Mass Hyper-Responders" aka people on low carb diets may have different implications. I went low carb for 2 weeks and my LDL level increased from 140 to 187. My HDL levels remained high and triglycerides low but my Apo B levels increased as well. This is while being on omega 3, red yeast rice, and berberine. I want to be on Natokinase but was told I cannot while on hormones replacement therapy. Can you help me understand how LDL works? Can I use Natokinase while on HRT safely? Thanks so much!       Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3753 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!