Podcasts about ldl

The real danger in bread isn't the gluten. In this video, we'll explain why bread can be unhealthy, how it affects insulin and blood sugar, and what you can eat instead if you decide to stop eating bread.0:00 Introduction: Why bread is unhealthy1:14 The bread blood sugar spike 1:50 The gluten myth 2:54 Bread dangers6:37 Is whole wheat bread healthy? 7:40 Gluten allergies8:22 Modern wheat dangersDownload Dr. Berg's Free Daily Health Routine: https://drbrg.co/45qtO07Bread is mostly starch, which is a chain of glucose molecules. Even if the label says zero grams of sugar, that starch is quickly broken down into sugar in your bloodstream.Wheat is in many of the foods people eat regularly: pizza, cereal, granola bars, and more. The average American consumes wheat almost every day.One of the biggest problems with bread is the blood sugar spike. In some cases, bread can spike your blood sugar even more than table sugar, despite being labeled as having zero sugar.Gluten-free bread isn't always a healthier option. Many gluten-free breads are made with potato starch, rice flour, tapioca starch, or cornstarch instead of wheat flour. These ingredients can spike blood sugar just as much as, if not more than, regular sugar. The starch in bread doesn't just affect blood sugar. It may also contribute to higher LDL cholesterol, fatty liver, and glycation.When bread spikes your blood sugar, insulin is released to bring it down. But where does the excess sugar go? Much of it gets converted into stored fat in the liver and around the belly. Over time, repeated blood sugar spikes and high insulin levels can lead to insulin resistance.While a small percentage of people have a true gluten allergy or sensitivity, for many others, the real issue with bread is the starch. Modern wheat has also been heavily hybridized and engineered to contain higher levels of gluten.Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

Editorial note:  We recorded this episode on March 4. This is an important detail for contextualizing the timeline of events discussed in this episode, as well as our understanding of the matter at the time of recording.  Since we recorded this episode, the paper discussed has been officially retracted. We will provide additional updates on this story as they become available.   Episode summary: Join Eric Trexler and Eric Helms as they dissect the chaotic rollout of a controversial study on LDL cholesterol and lean mass hyper responders, explore issues in science communication, and debate the integrity of research in the age of social media. If you're in the market for some new lifting gear or apparel, be sure to use code "MRR10" at elitefts.com for a 10% discount   Chapters 00:00 Intro 09:18 Social media dust-up 17:27 Revisiting the "Lean Mass Hyper Responder Study" 23:25 New controversy surrounding the study 33:14 Investigations regarding data integrity 41:43 Historical Context: NUSI and Its Implications 50:55 Steelmanning the argument 55:22 Potential issues with the "citizen science" movement 01:01:50 The death of expertise and the future of science communication

In this evidence-packed episode, Dr. Scott Watier and Tommy Welling dissect a December 2025 systematic review and meta-analysis from Frontiers in Nutrition examining how intermittent fasting improves metabolic syndrome outcomes compared to traditional calorie restriction. They reveal that participants with metabolic syndrome—defined as having three or more risk factors including elevated waist circumference, high triglycerides, low HDL, elevated blood pressure, and high fasting glucose—experienced significant improvements in fasting blood glucose, A1C, insulin resistance, LDL cholesterol, and inflammatory markers with high certainty of evidence when using various IF protocols. The hosts explain why smart, experienced people spend years tracking and counting calories yet feel stuck, emphasizing that intermittent fasting addresses the root drivers of metabolic dysfunction rather than just creating a caloric deficit through willpower and restriction. They demonstrate how modified alternate-day fasting showed 50-100% greater reductions in inflammatory markers over 16 weeks, and why time-restricted eating delivers faster blood sugar improvements, providing practical guidance on matching your fasting pattern to your metabolic profile while focusing on beneath-the-surface changes happening long before the scale or the world can see them. ⁠⁠⁠⁠⁠⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://pubmed.ncbi.nlm.nih.gov/41459076/

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib, an investigational drug that has captured his attention and renewed interest in an entire class of therapies known as CETP inhibitors. He explains what obicetrapib is and how it works, revisits the history of CETP inhibitors and why earlier versions of these drugs failed—sometimes dramatically—and breaks down the key clinical trials designed to evaluate their impact on cardiovascular risk. Peter examines how obicetrapib influences major lipid biomarkers, including LDL cholesterol and lipoprotein(a) [Lp(a)], and discusses emerging evidence from a study that explored the drug's effects on Alzheimer's-related blood biomarkers. He also highlights intriguing findings in individuals carrying the APOE4 allele and reflects on what these early results may mean for both cardiovascular disease prevention and potential implications for Alzheimer's risk, as well as how he is thinking about this therapy in the context of caring for his own patients. We discuss: Introducing obicetrapib: CETP inhibitor history, lipid biology, and early Alzheimer's biomarker signals in APOE4 carriers [2:15]; CETP biology explained: lipoproteins, reverse cholesterol transport, and how CETP inhibition alters HDL and LDL particles [5:15]; The early CETP inhibitor story: why raising HDL cholesterol alone failed to deliver cardiovascular protection [13:45]; The rise and fall of early CETP inhibitors: torcetrapib, dalcetrapib, evacetrapib, and anacetrapib [18:30]; Why obicetrapib may succeed where earlier CETP inhibitors failed [23:30]; The BROADWAY trial: obicetrapib's effects on LDL, ApoB, Lp(a), and residual cardiovascular risk [26:00]; Brain lipid metabolism and APOE4: how CETP inhibition may influence cholesterol transport in Alzheimer's disease [30:45]; Findings from the substudy of the BROADWAY trial which looked at changes in biomarkers of Alzheimer's disease [40:00]; Interpreting the BROADWAY Alzheimer's biomarker results: limitations, cautious optimism, and the need for a dedicated prevention trial [46:45]; Why Peter is optimistic about obicetrapib: cardiovascular benefits, Lp(a) reduction, and the path toward approval [50:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Broadcast from KSQD, Santa Cruz on 3-12-2026: Dr. Dawn discusses Michael Pollan's critique of MAHA dietary recommendations, agreeing that ultra-processed foods should be avoided but noting the lack of science supporting high saturated fat intake. She acknowledges extra virgin coconut oil as an exception that doesn't raise LDL, and pushes back on the social Darwinism embedded in anti-vaccine, anti-welfare MAHA thinking. Dr. Dawn expresses serious concern about Surgeon General nominee Casey Means, a Stanford-trained physician who dropped out of residency to become a wellness influencer. She objects to Means hawking supplements and glucose monitors for personal profit—conduct she considers unethical for a physician giving medical advice. An emailer from Switzerland shares success managing histamine intolerance by avoiding aged meats, shellfish, fermented foods, and cross-reactive pollens during hay fever season. The game-changer was taking DAO (diamine oxidase) supplements before meals to break down histamine in the gut. Researchers found that blood from pediatricians who worked in children's hospitals for over a decade contains powerful antibodies against RSV—up to 25% more effective than existing treatments—built up through years of constant exposure. Dr. Dawn critiques a study finding 2.5 times more microplastics in prostate tumor tissue than surrounding healthy tissue, noting that fast-growing cancers develop extra blood vessels and would naturally incorporate more circulating plastics. She attributes the 6% rise in late-stage prostate cancer to discontinued PSA screening rather than microplastics. An emailer asks what to do about microplastics already in our bodies. Dr. Dawn says there's no way to remove them, and advises avoiding microwaving in plastic, limiting breaded processed foods, and rinsing well after brushing teeth with plastic bristles. AI analysis of mammograms can now detect breast artery calcification as a marker for cardiovascular disease risk, with severe calcification indicating 3.3 times greater risk of heart attack, stroke, or death. This could identify high-risk women years before cardiac events. Dr. Dawn questions a non-peer-reviewed study presented at an orthopedic meeting found five years of GLP-1 drug use associated with 30% higher osteoporosis risk, 150% higher osteomalacia risk, and increased tendon ruptures—likely from reduced food intake and vitamin D consumption. Twin studies now estimate genetics account for 55% of lifespan variation when separating internal biological causes from external factors. Separately, fathers who showed warmth and responsiveness to 10-month-old babies had children with lower inflammation and better blood sugar regulation at age 7—an effect not seen with mothers' parenting. Grandparents actively involved in childcare showed slower cognitive decline than non-caregiving grandparents. Dancing emerged as the standout physical activity for dementia prevention—combining aerobic exercise, social interaction, music, and motor coordination—with three hours weekly showing observable benefits.

Angela and special guest Dr. Darshan Shah, look at the polarising world of cardiovascular health, specifically demystifying the role of LDL cholesterol.  They challenge the traditional one-size-fits-all approach to statins, arguing that heart health must be viewed through the lens of individual biology—where factors like inflammation, genetic risk, and lifestyle can make the same LDL level a non-issue for one person and a crisis for another WHAT YOU WILL LEARN LDL is Not Always the Enemy: A high LDL reading alone doesn't guarantee heart disease; its impact depends on individual context The Power of ApoB and Lp(a): Traditional cholesterol panels are often insufficient; more modern biomarkers like ApoB(a superior risk marker) and Lp(a) (a genetic factor) provide a much clearer picture of cardiovascular risk. AI in Diagnostics: The Clearly scan uses AI to analyse CT angiograms, allowing doctors to see the actual buildup of both calcified and soft plaque in the coronary arteries rather than just guessing based on blood work. Precision Over Dogma: Because cardiovascular health is an "N-of-1" situation, interventions like statins or PCSK9 inhibitors should be based on actual arterial health TIMESTAMPS: 01:21 The LDL Controversy: An explanation of why cholesterol remains a polarizing topic and why it must be treated as an individual biology issue. 02:37 The Tale of Two Patients: A comparison of a healthy gym-goer with high LDL/zero plaque versus a high-stress professional with lower LDL/significant plaque. 04:13 Modern Biomarkers: A breakdown of the specific tests to ask for, including ApoB, HS-CRP, and the Clearly cardiovascular scan. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

In this episode of the Neuroveda Podcast for Complex Health, Gillian Ehrlich, ARNP, sits down with Dr. Carley Squires to discuss apheresis, with a focus on therapeutic plasma exchange (TPE), also known as plasmapheresis.Apheresis means the removal of something from the blood, and the type of apheresis depends on what is being removed. At Neuroveda, the focus is plasma apheresis, meaning plasma is removed and replaced with albumin and saline. Therapeutic plasma exchange is an extracorporeal blood purification technique designed to remove a portion of plasma that may contain potentially harmful substances such as autoantibodies, inflammatory cytokines, immune complexes, and other immune mediators involved in immune dysregulation.Dr. Squires explains the broader umbrella of therapeutic apheresis, including red blood cell exchange, leukapheresis, plateletpheresis, lipid/LDL apheresis, extracorporeal photopheresis, and H.E.L.P. apheresis. While H.E.L.P. apheresis is not currently available in the United States, interest in apheresis expanded during the rise of long COVID, when patients began traveling internationally for treatment.Therapeutic plasma exchange has been used for decades in hospital settings, primarily for autoimmune disease, but is now being explored for additional applications including long COVID, neuroinflammatory conditions, and longevity medicine. Research suggests TPE may help support immune modulation through mechanisms such as:• Removal of immune complexes• Reduction of inflammatory cytokines• Correction of altered Th1/Th2 immune balance• Increased T regulatory and T suppressor cellsEmerging research has also explored TPE for PANDAS/PANS, pediatric autoimmune neuropsychiatric disorders triggered by infection.Referenceshttps://www.sciencedirect.com/science/article/pii/S0149763417305833https://pubmed.ncbi.nlm.nih.gov/10513708/While additional research is still needed for many of these applications, Neuroveda has also observed significant clinical improvements over the past several years, including reductions in toxic burden from mycotoxins, heavy metals, solvents, plastics, and other persistent environmental toxins.The episode also reviews current American Society for Apheresis (ASFA) guidance, which places many emerging uses of apheresis into Category III, meaning the optimal role is still being defined and treatment decisions should be individualized.ReferenceConnelly-Smith L, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice. J Clin Apher. 2023.Listeners will also hear what to expect from a TPE treatment at Neuroveda. Each session lasts approximately 2–4 hours, during which blood circulates through a machine that separates and removes plasma while returning the remaining blood components with replacement fluid.Although the procedure may sound invasive, TPE is generally well tolerated and safely performed in outpatient settings. Vital signs are monitored throughout treatment, and most patients experience only mild side effects such as fatigue, lightheadedness, or temporary electrolyte shifts.One unique aspect of Neuroveda's approach is the integration of Ayurvedic medicine with modern therapeutic plasma exchange. Ayurvedic therapies use oils, massage, steam, and other treatments to mobilize lipophilic toxins from deeper tissues back into circulation. Because TPE removes substances circulating in the bloodstream, these therapies may help prepare the body for detoxification.This aligns with Panchakarma, Ayurveda's classical detoxification process, which includes rakta moksha, traditionally translated as “blood liberation.” In a modern context, TPE can be viewed as a technological evolution of this ancient concept.Rather than functioning as a stand-alone cure, TPE is often most effective as part of a comprehensive program that may include functional medicine, regenerative medicine,

A new meta-analysis just dropped, and once again, saturated fat takes center stage. But does the data actually support the decades-long warnings we've heard about saturated fat and heart disease? Not exactly.In this video, Dr. Bret Scher dives deep into a recent study published in the Annals of Internal Medicine that reviewed randomized controlled trials on saturated fat intake and health outcomes.Despite the headlines and abstract language hinting at risk, a closer look at the data reveals no statistically significant increase in heart attacks, strokes, or early death, even with modest increases in LDL.So why the disconnect between what the data shows and what the authors claim? Dr. Scher breaks it down and explores the nuances often missing from the conversation about saturated fat, including context like food quality, carbohydrate intake, metabolic health, and lifestyle factors that make a big difference.

Support your health journey with our private practice! Explore comprehensive lab testing, functional assessments, and expert guidance for your wellness journey. Find exclusive offers for podcast listeners at nutritionwithjudy.com/podcast. _____**Podcast Update: It looks like I accidentally switched the terms: absolute risk reduction vs relative risk reduction. Regardless of the terminologies, the point was to see what funny games statisticians will use for marketing pharma drugs (and this happens in a lot of types of marketing...) To see a clear write-up of the absolute risk vs relative risk, you can read an article I shared about it: https://www.nutritionwithjudy.com/old-newsletter/why-statins-dont-stop-heart-attacks/In this episode, I walk through why statins are prescribed (especially with LDL above 190 mg/dL or with type 2 diabetes), and I explain how statin marketing can make the benefits look bigger than they really are by using relative risk instead of absolute risk. I also cover major concerns I see with statins, including nutrient depletion (like CoQ10) and potential impacts on muscle function over time. Make sure to listen to the full interview to learn more.The statin numbers (the what, why)Lipitor ad: relative vs absolute risk reductionStatin efficacy studies (and risks)Statins reduce nutrient status (including CoQ10)Risks of low cholesterolWhat to test and track for heart diseaseNew book cover _____EPISODE RESOURCES Join the NewsletterCarnivore Diet Cholesterol Labs Cardiovascular Blood TestStatin Use Is Associated With a Decline in Muscle Function and Mass Over Time (PubMed)Should You Take a Statin for Your High Cholesterol? (Yale Medicine)Lipitor Ad Highlighting Relative Risk Reduction (36%) vs Absolute Risk (3% vs 2%) (ResearchGate Figure)Atorvastatin Decreases Blood Coenzyme Q10 in Patients at Risk for CVD and Stroke (JAMA/Arch Neurol)Lipitor: Why It Remains the Best-Selling Drug in Pharmaceutical History (Accio)Heart Statistics: Cardiovascular Disease Statistics for the UK (British Heart Foundation)WHO Mortality Database (World Health Organization)Robert Jarvik (Artificial Heart Developer) (Wikipedia)Pfizer, Lipitor (atorvastatin calcium) print advertisement featuring Robert Jarvik, ca. 2006–2008.____FIND JUDY CHO⛑️Work with Us: https://empowerfunctionalhealth.com/services/

High cholesterol is one of the most widely discussed—and established—risk factors in medicine. But reams of research now show that while it is key to cardiovascular risk, it is not the whole story.In this episode of A Whole New Level, editorial director Mike Haney sits down with Dr. Ronald Krauss, one of the world's leading lipid researchers and a pioneer in understanding how different forms of LDL—and the physiological factors around them—affect cardiovascular risk.Dr. Krauss explains why the basic link between cholesterol and heart disease is well established among experts—but also why the standard cholesterol panel often misses the deeper metabolic story. Drawing on decades of research, he walks through how lipoproteins, particle size, triglycerides, and metabolic health interact to determine whether cholesterol actually becomes dangerous.Along the way, the conversation explores why cardiovascular disease remains the leading killer despite statins and decades of research—and how factors like obesity, insulin resistance, and inflammation reshape the lipid landscape in ways that traditional tests may not capture.The result is a clearer framework for understanding cardiovascular risk: not just how much cholesterol is in the blood, but how it's being transported, how long those particles circulate, and what metabolic conditions are driving them.Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠https://levels.link/wnl⁠⁠In this episode, we coverWhy the cholesterol–heart disease link isn't actually controversial among researchersCholesterol vs. lipoproteins: why the particles carrying cholesterol matter more than the number itselfSmall dense LDL: how triglyceride metabolism produces the most harmful particlesApoB and particle counts: why many researchers prefer measuring particles instead of cholesterol massLipoprotein(a): the genetically driven risk factor affecting up to a third of the populationMetabolic syndrome: the cluster of conditions that amplifies cardiovascular riskWhy carbohydrates and metabolic dysfunction can drive harmful lipid patternsThe saturated fat debate: why food context and metabolic health matter more than simple fat categories

More on vitamin E studies.How do I know which ingredients to avoid in my shampoo and soaps?I have lower back pain that came out of the blue!What's the best vitamin C to take for a 78-year-old?Which brand of PEA is the most bioavailable?

Want to reverse the declines of ageing? Check your attitude.What are good supplements to take before and after a CT angiogram or any CT with contrast?Can vitamin E increase the risk of hemorrhagic stroke?Is turmeric more bioavailable than curcumin? How much should I use?

This educational content details how the liver regulates cholesterol through both its internal production and the absorption of particles from the bloodstream. When a patient takes statin medications, the drug blocks a specific enzyme to inhibit cholesterol synthesis within liver cells. This internal shortage triggers the liver to increase its production of surface receptors designed to capture low-density lipoprotein (LDL) from the blood. Consequently, these extra receptors effectively pull more LDL out of circulation, leading to a significant drop in overall plasma cholesterol levels. By explaining this biological feedback loop, the source clarifies the primary mechanism behind how common heart medications improve cardiovascular health.

Send a textWhat if a lower LDL comes with a quiet cost to your strength and resilience? We dig into a massive biobank analysis linking long-term statin use with declines in grip strength and appendicular lean mass, then connect the dots to sarcopenia, mitochondrial function, and the daily choices that shape metabolic health. Strength is more than performance; it predicts independence, glucose control, and longevity, which is why any therapy that erodes muscle demands a closer look.We walk through the study's design, what “appendicular lean mass” really measures, and why the findings held even after adjusting for lifestyle and genetics like SLCO1B1. From there, we peel back the LDL-centric mindset and focus on terrain: insulin, inflammation, triglycerides, HDL, and LDL particle quality. You'll hear why refined carbs, seed oils, and chronic inflammation push lipoproteins in the wrong direction—and how protein-forward meals, resistance training, and lower insulin load tip the balance toward larger, less atherogenic particles with benefits that extend well beyond a single lab value.We also compare statins with hydrophilic options, alternate dosing strategies, and newer PCSK9 inhibitors, clarifying where they may fit for secondary prevention and where big questions remain—especially around muscle preservation and all-cause mortality. CoQ10 gets a fair review: low risk, mixed evidence, and not a proven fix for long-term function. Most importantly, we share practical steps to protect your muscle: track grip strength, prioritize 1.6 to 2.0 g/kg daily protein, lift two to three times per week, walk after meals, and align circadian rhythms with sleep and sunlight. Medications can lower numbers; only your muscles move you through life. Let's make treatment plans that respect both.If this conversation helped you think differently about risk and resilience, follow the show, share it with a friend, and leave a quick review so more listeners can find thoughtful, evidence-informed health guidance.For slides, open source references and video go to: www.thehealthedgepodcast.com

¿Qué sabemos realmente, a nivel molecular, sobre el efecto del aceite de oliva en la salud cardiovascular?Jesús de la Osada lleva más de treinta años investigando las bases moleculares de la aterosclerosis y el papel de los componentes de la dieta mediterránea en la salud cardiovascular. En este episodio repasa cómo se construye conocimiento riguroso en un área donde la divulgación de baja calidad abunda, y qué significa eso en términos de lo que podemos afirmar con fundamento sobre el aceite de oliva virgen extra.La investigación del grupo arrancó cuando los estudios disponibles medían únicamente colesterol total, un marcador tan poco específico que el aceite de oliva resultó neutro y quedó décadas fuera del foco. Con la llegada de modelos animales que reproducen aterosclerosis en semanas y el avance de la química analítica, el panorama cambió. El aceite de oliva virgen extra contiene cerca de 400 compuestos identificados. El candidato inicial, el ácido oleico por ser el componente mayoritario, fue descartado experimentalmente. El compuesto que concentra hoy el trabajo del grupo es el escualeno: el más abundante, el más estable durante el almacenamiento y el que se absorbe y acumula en órganos. Es además un intermediario universal en la biosíntesis de esteroles, lo que explica su presencia en organismos tan distintos como el olivo o el tiburón, y su coincidencia en las dos poblaciones con menor mortalidad cardiovascular históricamente documentada: la mediterránea y la japonesa.Estudiarlo de forma aislada presenta un problema importante: fuera de su matriz natural, el escualeno se oxida con facilidad. La solución que el grupo ha desarrollado en colaboración con el Instituto de Nanomateriales de Aragón es la encapsulación en nanopartículas que aíslan el compuesto y replican la protección que ejerce el propio aceite. En paralelo, trabajan con un aceite de oliva virgen enriquecido en escualeno y un compuesto fenólico, desarrollado junto a una empresa chipriota, cuyos resultados preliminares son prometedores.Dedicamos parte de la conversación a la diferencia entre evidencia in vitro y evidencia clínica, y por qué esa distinción es relevante para evaluar las afirmaciones que rodean a suplementos y nutracéuticos. El marco regulatorio para uso alimentario no exige demostrar eficacia, solo ausencia de toxicidad. Eso permite construir argumentos sobre mecanismos reales sin evidencia de que funcionen en humanos a las dosis habituales. No es necesariamente fraudulento, pero el salto entre ambas cosas rara vez se explicita.Hablamos también del estado actual del diagnóstico cardiovascular. Más allá del colesterol total y la distinción LDL/HDL, hay marcadores con mayor valor predictivo que no se usan de rutina: la Lp(a), el tamaño de las partículas de LDL, o la cuantificación de ApoB-100, que refleja el número de partículas en circulación independientemente del colesterol que transportan. La razón por la que estos marcadores no se incorporan de forma sistemática no es científica sino económica. Lo mismo ocurre con la farmacogenómica aplicada a estatinas: sabemos que los citocromos P450 implicados en su metabolismo tienen variantes con distinta actividad, pero la caracterización de cada paciente antes de prescribir sigue siendo la excepción, no la norma.Página Web del grupo: https://osada.unizar.esNuevos aceites: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.70223Escualeno: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201800136Aceite de oliva virgen: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100668Nuevos modelos para estudio de aterosclerosis: https://www.imrpress.com/journal/FBL/11/1/10.2741/1852Si el episodio te ha resultado interesante, puedes apoyarlo dándole a like, suscribiéndote o compartiéndolo en tu plataforma habitual (Spotify, Apple Podcasts, iVoox, YouTube, etc.). Es un gesto que te cuesta muy poco y que ayuda muchísimo a que este podcast siga creciendo y llegue a más personas.

A new documentary exploring one of the most debated topics in metabolic health—the rise in LDL cholesterol sometimes seen in people following low-carbohydrate diets—is beginning its global rollout. In this episode of the LowCarbUSA® Podcast, I spoke with independent researcher Dave Feldman about his new documentary, The Cholesterol Code, which chronicles his research and the ongoing debate surrounding cholesterol and metabolic health. The movie is being premiered between March 15 and April 15 through multiple theatrical screenings around the world.  "If you don't see one in your community, then sign up to host your own screening in your area. Dave, an engineer by training who became widely known in the low-carb community through his self-experiments and data-driven investigations, described how the project began with a personal question. "I'm the engineer who started obsessing about his cholesterol when it went sky high on a keto diet," he said. "Then came about a lot of my self-experiments, which ultimately led to forming the lipid energy model, which is now published." That model attempts to explain why some people—particularly those who are lean and metabolically healthy—experience unusually high LDL cholesterol levels when following a ketogenic or very low-carbohydrate diet. These individuals are known as lean mass hyper-responders, a term Feldman coined to describe people who exhibit a distinctive metabolic pattern: very high LDL cholesterol, high HDL cholesterol, and very low triglycerides. Investigating the Risk Question While the metabolic explanation for the phenomenon has attracted growing attention, Dave said the larger and more pressing question has always been risk. "How much does the risk of going on a keto diet and then seeing your LDL go up— even if it is for these reasons—actually matter?" he said. "How much could this develop what's known as atherosclerosis, the building up of plaque in the arteries?" To explore that question, he launched a crowdfunded research effort through the Citizen Science Foundation. The study recruited 100 individuals identified as lean mass hyper-responders. Participants underwent advanced heart imaging using CT angiography at the Lundquist Institute, allowing researchers to measure plaque in the coronary arteries. "They get a baseline scan, and then one year later they get a follow-up scan," he explained. "That way we can see the changes of plaque over time—not just individually, but also at a population level." From Research Project to Documentary The documentary The Cholesterol Code captures the unfolding story of that research. According to Dave, filmmaker Jen Eisenhart began documenting the project shortly after the first baseline scan data became available. "They started filming and managed to capture all of this," he said. "It's a riveting story and it all comes together in this film." The documentary follows not only the scientific investigation but also the real-world experiences of people who adopted low-carbohydrate diets for serious medical conditions Many participants, he said, had experienced life-changing improvements—only to later face anxiety when routine blood tests showed rising LDL cholesterol levels. "They see their cholesterol go up and they go, 'Is this actually worth it?'" Dave said. "Even if I really respond well to a low-carb diet—even if I'm doing great—my cholesterol goes up. What does that mean?" The film includes interviews with individuals managing conditions such as type 1 diabetes, bipolar disorder, eating disorders, and inflammatory bowel disease. Their stories are really touching, hats off to Jen Eisenhart and her team. It's such a great film. I feel those stories were among the most powerful moments in the film. One of the mental-health stories, particularly,  just ripped my heart out. She got her life back. She got her children back. And then she was agonizing about whether she should stop because her LDL was going up. Research Complications and Scientific Debate The research itself has also drawn attention because of an unexpected analytical complication that arose during the study. Dave explains that a secondary analysis conducted using artificial intelligence–guided plaque imaging software produced results that differed from other analyses of the same scans. "Three of those analyses disagree with this one," he says. "On top of that, the company that provides that analysis won't do a quality control check." As a result, the research team has requested retraction of the paper associated with that analysis while further investigation continues. "That development ultimately strengthened the documentary by extending filming and allowing additional analysis and interviews to be incorporated. The neat thing is this delay did give us a chance to tighten up the movie more." Community-Driven Film Screenings The film is now being released through a community-driven screening model. Viewers can organize or attend screenings through the film's website, which uses a platform that allows communities to request theatrical showings once a minimum number of tickets are reserved. "If they go to the website, that's where they can either join an existing screening—of which there are now many across the United States and actually across the world—or they can host their own," Dave said.  I really encourage listeners to participate. If you don't see one in your community, then sign up to host a screening and try to activate your community. Continuing Research Beyond the documentary, Dave said the work is continuing with additional research initiatives. One upcoming project—currently referred to as the Triad Study—aims to further investigate the metabolic patterns associated with lean mass hyper-responders and their cardiovascular implications. "We're hoping to close funding on our companion research study,"he said. "The numbers are looking pretty good." As debate continues about the role of cholesterol in metabolic health—particularly among people following carbohydrate-restricted diets—Dave believes the conversation must remain grounded in data and open scientific inquiry. For many viewers, the documentary offers both a scientific investigation and a human story about the intersection of metabolic health, medical uncertainty, and personal transformation. "It's a great film and it tells a story that a lot of people in this community are living right now."

This episode is brought to you by State & Liberty, Caldera Lab, and Strong Coffee Company. Heart disease is still the number one cause of death worldwide, yet most people misunderstand what actually causes cardiovascular disease. In this episode of Ever Forward Radio, we sit down with interventional cardiologist Dr. Christopher Davis, MD to break down the real drivers of heart disease, the role of cholesterol, and why nitric oxide may be one of the most important molecules for cardiovascular health. This masterclass explores the science behind oxidized LDL, endothelial dysfunction, nitric oxide production, inflammation, and environmental toxins — and how these factors silently damage your arteries long before a heart attack occurs. ----- 00:00 – Cardiovascular Disease: The #1 Killer 02:15 – Why Heart Attacks Often Happen Without Severe Blockage 04:50 – The Misunderstanding Around Cholesterol 07:35 – Oxidized LDL and Plaque Formation 10:42 – Lipoprotein(a) and Genetic Risk 13:25 – Environmental Toxins and Cardiovascular Disease 16:10 – Endothelial Dysfunction Explained 19:40 – Nitric Oxide: The Molecule That Regulates Blood Flow 24:15 – Why Nitric Oxide Declines With Age 28:05 – Inflammation and Plaque Rupture 31:30 – The Arginine Paradox 35:12 – Symptoms of Nitric Oxide Deficiency 38:45 – Erectile Dysfunction as a Cardiovascular Warning Sign 42:20 – Mouthwash and Nitric Oxide Suppression 46:18 – Stress, Cortisol, and Arterial Damage 50:05 – Exercise and Nitric Oxide Production 55:40 – Environmental Stressors on the Cardiovascular System 59:10 – Tests That Actually Predict Heart Disease 01:05:30 – Practical Steps to Protect Your Heart ----- Episode resources: Save 15% on men's clothes made for athletic guys with code EVERFORWARD at https://www.StateAndLiberty.com Save 20% on men's skincare with code EVERFORWARD at https://www.CalderaLab.com Save 15% on organic lattes and coffee with code CHASE at https://www.StrongCoffeeCompany.com  Watch and subscribe on YouTube

What if everything your doctor told you about cholesterol is based on corrupted science? In this episode of the Gut Check Project, Dr. Kenneth Brown and Eric Rieger dive deep into the emerging world of Lean Mass Hyper Responders (LMHR) - metabolically healthy people on ketogenic and carnivore diets whose LDL numbers look alarming on paper but may tell a completely different story in real life.They break down a groundbreaking citizen-science study led by Dave Feldman and Dr. Nick Noritz that's challenging decades of lipid orthodoxy, explore why high LDL + high HDL + low triglycerides may not be the death sentence mainstream medicine makes it out to be, and share the story of a 53-year-old marathon runner with "normal" cholesterol who still ended up in the cath lab.If you or someone you love has been told to go on statins, this episode is required listening.Topics covered:The LMHR phenotype and what it means for keto/carnivore dietersWhy Ansel Keys and the sugar industry shaped a generation of bad dietary advicePlaque progression, inflammatory markers (hs-CRP), and what actually predicts heart diseaseWhy the Clearly AI cardiac scan study raised more questions than answersThe difference between dangerous cholesterol and protective cholesterol

Dr. Kim Brockenbrough: https://www.cardiavision.com/https://www.linkedin.com/in/kimberly-brockenbrough-md-1b321a123/https://www.instagram.com/kimbromd?ighsh=YjVpcDcwdHA3ejVvYour calcium score came back zero. You're in the clear, right? Not so fast.In this episode, Optispan Clinical Director Dr. Nicki Byrne sits down with Dr. Kim Brockenbrough, board-certified cardiovascular radiologist, 25-year veteran of vascular imaging, and CEO of CardiaVision, for a conversation that challenges one of the most common assumptions in preventive cardiology.If you care about cardiovascular longevity, and you should, because heart disease remains the leading killer, this is the imaging conversation you didn't know you needed.Timestamps:00:00 — Cold open: The 48-year-old runner with an 80% blockage and a zero calcium score00:54 — Dr. Nicki Byrne introduces Dr. Kim Brockenbrough & CardiaVision01:45 — Dr. Brockenbrough's background: 25 years of vascular imaging02:35 — Cardiovascular disease through a longevity lens: imaging vs. labs vs. functional testing03:24 — The lifecycle of plaque: from fatty deposits to rupture and heart attack04:21 — Why soft plaque is more dangerous than calcified plaque (SCOT-HEART 2020)05:14 — How calcium scores are used in clinical practice — and where they fall short06:18 — The only way to see soft plaque non-invasively: coronary CT angiography (CCTA)07:08 — Which populations are most at risk of a false sense of security from calcium scoring08:03 — What a CCTA can tell you that a calcium score can't09:43 — How often should patients follow up with repeat scans?10:28 — Higher vs. lower dose radiation protocols — and why Dr. Brockenbrough chooses higher dose11:17 — Risks of CCTA: contrast reactions, kidney considerations12:15 — Stress tests vs. CCTA: why a negative stress test is a very low bar13:21 — Soft plaque that isn't flow-limiting: small emboli, dementia, and congestive heart failure15:36 — Medications that reverse plaque: statins, PCSK9 inhibitors, and the LOCATE trial16:23 — LDL reduction and plaque regression: what the data shows17:08 — High-intensity statins vs. Repatha — tolerability, efficacy, and the price drop18:27 — When OptiSpan reaches for PCSK9 inhibitors: ApoB, LDL, Lp(a), ApoE4, and significant disease19:22 — Why a rising calcium score on a statin is exactly what you want to see20:25 — AI plaque quantification tools: promise, limitations, and validation concerns22:54 — Has AI ever changed Dr. Brockenbrough's read? A real-world case23:40 — FFR-CT, the ISCHEMIA trial, and why stenting asymptomatic patients is no longer standard of care25:25 — The future of cardiac imaging and the case for universal CCTA screening26:52 — The patient experience: what to expect at a CardiaVision CCTA appointment28:18 — Why seeing soft plaque changes patient behavior — the power of treating disease, not numbers29:49 — Bridging the gap between longevity medicine and traditional cardiology33:11 — Testosterone, the TRAVERSE trial, and what you should know about your coronaries first35:41 — What causes coronary artery disease beyond cholesterol: sugar, inflammation, gum disease37:07 — Image walkthrough: soft plaque vs. calcified plaque on a real CCTA41:36 — Where to find Dr. Brockenbrough and CardiaVision

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3317: Nancy Clark reminds us that even fit, “skinny” athletes aren't immune to heart disease, and that no one can out-exercise a poor diet. Drawing from the American Heart Association's latest guidelines, she explains how simple, sustainable eating patterns support not only long-term heart health but also peak athletic performance. Learn how small daily choices, from whole grains to healthy fats, can protect your heart while fueling miles of smiles. Read along with the original article(s) here: https://nancyclarkrd.com/2022/02/11/yes-even-athletes-get-heart-disease/ Quotes to ponder: “No one can out-exercise a bad diet.” “Given cardiovascular disease (CVD) starts in the womb, adopting heart-healthy eating patterns early and maintaining them throughout one's life is important.” “Replacing hard-at-room-temperature saturated fats (butter, coconut oil) with soft-or-liquid polyunsaturated and monounsaturated fats, has robust scientific evidence of protecting against heart disease by lowering bad LDL cholesterol.” Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3317: Nancy Clark reminds us that even fit, “skinny” athletes aren't immune to heart disease, and that no one can out-exercise a poor diet. Drawing from the American Heart Association's latest guidelines, she explains how simple, sustainable eating patterns support not only long-term heart health but also peak athletic performance. Learn how small daily choices, from whole grains to healthy fats, can protect your heart while fueling miles of smiles. Read along with the original article(s) here: https://nancyclarkrd.com/2022/02/11/yes-even-athletes-get-heart-disease/ Quotes to ponder: “No one can out-exercise a bad diet.” “Given cardiovascular disease (CVD) starts in the womb, adopting heart-healthy eating patterns early and maintaining them throughout one's life is important.” “Replacing hard-at-room-temperature saturated fats (butter, coconut oil) with soft-or-liquid polyunsaturated and monounsaturated fats, has robust scientific evidence of protecting against heart disease by lowering bad LDL cholesterol.” Learn more about your ad choices. Visit megaphone.fm/adchoices

A new meta-analysis of 174 randomized controlled trials on “carbohydrate-restricted diets” found consistent benefits for body composition, blood pressure, inflammation, and more. But instead of highlighting the metabolic benefits, most of the headlines focused almost entirely on a small bump in LDL.In this video, Dr. Bret Scher breaks down why that reaction misses the point and how biases in nutrition reporting are holding back real progress in improving metabolic health.

The script explains why fiber is critical for gut and metabolic health, focusing on how soluble fiber is fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate). It contrasts soluble fiber (forms a gel, lowers LDL by binding bile acids, slows glucose absorption, increases satiety, feeds the microbiome) with insoluble fiber (adds stool bulk, helps constipation). It highlights research showing 10 g/day psyllium husk (Metamucil) is linked to a 10% reduction in all-cause mortality and typically lowers LDL about 7–15%. Butyrate is emphasized as the primary fuel for colonocytes, supporting gut barrier integrity and potentially reducing colon cancer risk, while also affecting mitochondria, inflammation, and the brain. Propionate influences liver cholesterol production and satiety hormones, and acetate provides systemic energy. Practical supplementation "stacks," dosing ranges, food sources, GI side effects, and timing cautions (e.g., separating psyllium from minerals) are discussed.   Metamucil (psyllium husk fiber) — https://www.metamucil.com/   Psyllium husk (soluble fiber) — https://medlineplus.gov/druginfo/meds/a601104.html Psyllium husk (PubMed search) — https://pubmed.ncbi.nlm.nih.gov/?term=psyllium+husk   Soluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html Insoluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html   Inulin (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=inulin+prebiotic+fiber   Acacia fiber / Gum arabic (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=acacia+fiber+gum+arabic+prebiotic   Beta-glucan (oats/barley soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=beta-glucan+oats+LDL   Pectin (soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=pectin+soluble+fiber   Partially hydrolyzed guar gum (PHGG) — https://pubmed.ncbi.nlm.nih.gov/?term=partially+hydrolyzed+guar+gum   Resistant starch / Potato starch — https://pubmed.ncbi.nlm.nih.gov/?term=resistant+starch+potato+starch   Short-chain fatty acids (SCFAs) — https://www.ncbi.nlm.nih.gov/books/NBK557571/   Butyrate (SCFA) — https://pubmed.ncbi.nlm.nih.gov/?term=butyrate+short-chain+fatty+acid+colonocytes   LDL cholesterol (general) — https://medlineplus.gov/cholesterol.html   Magnesium (mineral supplement info) — https://medlineplus.gov/magnesium.html   Show Notes   00:00 Butyrate and Colon Health 00:49 Why Fiber Matters Now 02:28 How Fiber Is Digested 03:45 Soluble vs Insoluble Fiber 06:36 Gel Effect on Blood Sugar 07:36 How Soluble Fiber Lowers LDL 10:19 Short Chain Fatty Acids 101 11:32 Butyrate Deep Dive 16:40 Propionate and Liver Benefits 18:22 Acetate for Energy and Appetite 19:29 Best Fibers to Supplement 21:33 Dosing and Food Sources 24:44 Ideal Fiber Stack and Safety 28:37 Wrap Up and Next Steps   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Have you ever been told your labs are “normal” — but you don't feel normal?In this episode, I sit down with integrative and functional medicine physician Aaron Hartman, author of Uncurable, to unpack the dangerous gap between normal and optimal — especially for women in midlife.We cover:What lab reference ranges really meanThe cardiovascular markers every woman should know (hs-CRP, LDL particle number, Lp(a), ApoB, homocysteine)Why LDL alone is outdated thinkingThyroid testing beyond TSH (free T3, free T4, reverse T3, antibodies)Ferritin, B12, iodine & nutrient blind spotsEstrogen, progesterone & testosterone — when to start and what actually protects your brain and heartStatins, diabetes risk, and mitochondrial healthGut health, inflammation & autoimmune triggersWhy lifestyle is foundational — and where advanced longevity tools fit inDr. Hartman explains how heart disease begins decades before symptoms appear, why hormone replacement therapy dramatically reduces risk when used appropriately, and how women can advocate for themselves in a system that often dismisses midlife symptoms.If you care about your brain, your bones, your heart — and living strong into your 80s and 90s — this conversation is essential.Did you miss something? Check out the transcripts of the episode!You can find Aaron Hartman, MD at https://richmondfunctionalmedicine.com/Instagram https://www.instagram.com/aaronhartmanmd/His book, Uncurable: From Hopeless Diagnosis to Defying All Odds, is available where you buy books. _________________________________________If you're doing “all the right things” and still feel stuck, adding a layer of support may be an option. I've partnered with a trusted telehealth platform offering modern solutions for women in midlife—including micro-dosed GLP-1 and other peptide therapies. https://elliemd.com/michelefolan - Create a free account to view all products. Follow us on Instagram https://www.instagram.com/askingforafriend_pod/ ✨ Sign up for my weekly newsletter: https://michelefolanfasterway.myflodesk.com/i6i44jw4fq Like to connect? Email me at askingforafriendpodcast1@gmail.com Transcripts are created with AI and may not be perfectly accurate. Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your qualified healthcare provider with any questions regarding a medical condition.

In this episode, David Watumull breaks down the science behind astaxanthin — a powerful carotenoid antioxidant backed by over 4,000 peer-reviewed papers and 100+ human clinical trials — and explains why it may be one of the most underappreciated longevity compounds available today. The conversation explores how astaxanthin anchors across cellular membranes to protect mitochondria from oxidative stress, reduce chronic inflammation ("inflammaging"), support cardiovascular health by lowering oxidized LDL and CRP, and cross the blood-brain barrier to enhance cognitive function and neuroprotection. They also discuss its role in energy production, endurance performance, healthy aging, and a landmark NIH lifespan study showing a 12% extension in mammals. Ultimately, the episode reframes longevity not as chasing stimulants or shortcuts, but as protecting cellular integrity so the body can function the way it was designed to — for longer and at a higher level. ----- 00:00 – The Longevity Molecule You've Never Heard Of 02:45 – What Is Astaxanthin? 07:30 – How It Protects Your Cell Membranes 13:40 – Free Radicals & Oxidative Stress Explained 25:50 – Brain Health, Neuroplasticity & Mitochondria 29:40 – Cardiovascular Disease & Oxidized LDL 34:05 – Alzheimer's, MCI & Neuroprotection 43:00 – Energy Production & Mitochondrial Function 58:40 – Inflammaging & Longevity Pathways 1:03:40 – NIH Study: 12% Lifespan Extension 1:09:00 – Athletic Performance & Endurance 1:15:00 – Dosing, Absorption & Bioavailability 1:26:00 – Can Antioxidants Become Harmful? 1:30:00 – Why Isn't This Mainstream? 1:37:30 – Living Ever Forward ----- Episode resources: Save 20% with checkout code EVERFORWARD at https://www.AX3.Life.com Watch and subscribe on YouTube Learn more at https://ax3.life/pages/science 

What does over 18 months of precision medicine actually look like in practice? In this episode of the Optispan Success Story Series, Dr. Matt Kaeberlein sits down with Carlos Pinto, a tech executive and early Optispan client, to trace his longitudinal health journey from metabolic warning signs to measurable, sustained transformation. Carlos shares how a decade of overlooked biomarkers, a post-pandemic health decline, and a single panic attack became the catalyst for a data-driven approach to his own biology. Together, he and Dr. Kaeberlein review real DEXA, lipid, metabolic, and environmental biomarker data, unpacking what moved the needle, what didn't, and why the answer was rarely simple. This conversation is a candid look at what it means to become your own best health advocate, not through quick fixes, but through personalized, longitudinal learning.Timestamps:0:00 – Cold open & highlights0:50 – Welcome & Carlos's background in tech leadership2:15 – How career ambition displaced health in his 20s and 30s3:39 – A panic attack as the turning point: connecting mental and physical health4:24 – A previous medical wellness program: what worked and what was missing6:34 – Arriving at OptiSpan: intention, mindset, and expectations7:15 – Gateway Day: comprehensive baseline testing and initial surprises8:51 – Early metabolic lessons: CGM data, glucose spikes, and dawn effect11:32 – Confronting white coat hypertension with 78 data points13:28 – How stress, sleep, and nutrition interact to drive metabolic dysfunction15:44 – Personal experimentation as methodology: berberine, time-restricted eating, and fish17:09 – Mercury toxicity from fish consumption: a case study in biomarker surveillance18:33 – Stress management protocols: walking, meditation, and measurable outcomes19:49 – Statin introduction: the role of medication as a tool, not a failure20:27 – DEXA results: visceral fat reduction, body fat loss, and lean mass gain24:17 – Lipid profile transformation: ApoB from ~115 to 70, LDL from 160 to 7425:57 – A1C trajectory and the complexity of glucose optimization30:01 – Reframing medication: proactive use vs. reactive disease management31:29 – Mercury biomarker deep dive: from 2.4 to 16 and back to 232:21 – Goals for the future: sustainability, muscle retention, and mental clarity36:30 – Lineage biological age algorithm: from mortality risk of 54 to 5239:27 – Closing reflections: health as a lifelong trajectory, not a program

Send a textRole of bile acids in cholesterol regulation, digestion & metabolic diseases like diabetes.TOPICS DISCUSSED:Bile acids basics: They enable cholesterol excretion, with about half of bodily cholesterol eliminated this way, and also aid digestion by emulsifying fats to increase enzyme access.Bile production & pathway: Synthesized in liver hepatocytes, bile flows via ducts to the gallbladder for storage or directly to the small intestine; post-meal, cholecystokinin triggers gallbladder contraction for fat emulsification.Regulation of bile acids: Self-regulated to prevent cytotoxicity, as excess can damage cell membranes; insulin and bile acids themselves influence synthesis and transport, with defects in insulin-resistant states.Bile acids in metabolic diseases: Increased synthesis, especially 12-hydroxylated types, occurs in type 2 diabetes and insulin resistance, potentially as an adaptation for better nutrient absorption during perceived scarcity.Gallbladder removal & gallstones: Common due to cholesterol supersaturation forming stones; removal eliminates concentration but preserves bile flow, reducing tolerance for high-fat meals.Bariatric surgery impacts: Procedures like gastric bypass increase circulating bile acids without major synthesis changes, while more extreme ones boost synthesis due to impaired intestinal sensing.Cholesterol homeostasis: Cells tightly regulate membrane cholesterol for fluidity and signaling; most bodily cholesterol is synthesized internally, with LDL receptors key to blood levels.Ongoing research: Haeusler's lab explores manganese's role in metabolism, bile acids in liver inflammation, and insulin's effects on lipoproteins.ABOUT THE GUEST: Rebecca Haeusler, PhD is an associate professor at Columbia University in the departments of medicine and pathology and cell biology, affiliated with the Naomi Berrie Diabetes Center and the Digestive and Liver Diseases Research Center.RELATED EPISODE:M&M 269 | Soybean Oil: Obesity, Fatty Liver Disease, Gut Health, IBS & Colitis | Frances SladekSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

El nutricionista Ignacio Lillo, resuelve dudas sobre el colesterol: qué función cumple en nuestro organismo, cuándo se convierte en un factor de riesgo y cómo podemos mantenerlo en niveles saludables. Además, explica la diferencia entre el colesterol HDL —conocido como el “bueno”— y el LDL —el llamado “malo”—, su relación con la salud cardiovascular y qué hábitos alimentarios y de estilo de vida ayudan a mantener el equilibrio.

Broadcast from KSQD, Santa Cruz on 2-26-2026: Dr. Dawn opens with an urgent measles advisory, noting the virus has an R-value of 15 compared to COVID's peak of 5, with South Carolina reporting over 1,000 cases. She recommends those who received only one MMR shot—particularly people now in their 60s—get an immune titer blood test, as protection declines after 40-50 years. Measles can cause "immune amnesia" destroying immunity to other pathogens, and rarely leads to fatal subacute sclerosing panencephalitis years later. Dr. Dawn criticizes Quest Labs' cholesterol reporting, which flags average levels as "moderate risk" with alarming red H markers even when values fall within their own stated normal ranges. She explains this creates unnecessary panic and pushes patients toward statins based on outdated 2008-2012 guidelines, when cardiology has since recognized that cholesterol can be too low. An emailer asks how an EKG can detect a past heart attack from "jagged lines." Dr. Dawn explains that each spike represents electrical signals moving toward or away from electrode pads, and a 12-lead EKG views the heart from multiple angles—smaller-than-expected spikes in specific leads indicate dead or damaged heart muscle. She urges everyone to learn CPR and AED use, which more than doubles survival chances. An emailer reports that food tastes strong on the first bite but becomes tasteless thereafter. Dr. Dawn identifies numerous medications causing taste changes including calcium channel blockers, beta blockers, statins, diuretics, and even acetaminophen. She also highlights zinc—both deficiency and toxicity above 40mg daily can impair taste, noting a zinc nasal spray was pulled from market after causing smell loss. An emailer asks about Prenuvo full-body MRI scans costing $499-1,000. Dr. Dawn cautions that while Prenuvo found 22 cancers in 1,000 people scanned, 1 in 20 scans requires follow-up biopsy and more than half are false positives—leading to stress, expense, and potential complications from unnecessary procedures. An emailer asks about seed oils after reading a Johns Hopkins article defending them. Dr. Dawn distinguishes fruit oils (olive, avocado) from industrially-extracted seed oils requiring hexane solvent, a neurotoxin that may leave residues despite claims of evaporation. She cites a BMJ study showing coconut oil raised HDL (good cholesterol) while matching olive oil's LDL impact, and recommends cold-pressed oils while avoiding hexane-extracted products, especially for infants.

Heart disease is the leading cause of death — but it's also one of the most preventable conditions.  In this episode of The Exam Room, Dr. Neal Barnard joins Chuck Carroll to reveal the best foods for reversing heart disease, lowering cholesterol, and protecting your arteries naturally. Dr. Barnard breaks down the science behind oats, beans, walnuts, leafy greens, flaxseed, berries, and more — and explain how these foods help remove LDL cholesterol, improve endothelial function, and reduce inflammation. Can plaque really shrink? How fast can cholesterol levels drop? What should you eat if you've already had a heart attack? If you're serious about improving your cardiovascular health, this evidence-based conversation offers practical steps you can start today.

How much can what you eat really influence your heart health — and how quickly can you improve your blood pressure or cholesterol through diet? In this episode of Health Matters, host Courtney Allison sits down with cardiologist Dr. Sean Mendez of NewYork-Presbyterian Brooklyn Methodist Hospital to break down the real connection between food and cardiovascular wellbeing. They explore what your health numbers mean — from blood pressure ranges to LDL cholesterol, triglycerides, HDL, and the emerging marker ApoB — and how these values signal current or future risk. Dr. Mendez explains how dietary shifts can lower LDL cholesterol by 3 to 15 percent and reduce blood pressure by several points, even without medication. He also discusses salt sensitivity, the impact of saturated fats and processed foods, and why soluble fiber, healthy fats, and whole foods can play a powerful role in improving cholesterol. The conversation dives into the DASH diet and the Mediterranean diet, outlining how each works, what they emphasize, and the evidence behind their ability to reduce blood pressure and overall cardiovascular risk. Dr. Mendez offers practical tips for getting started and key lifestyle factors that are essential for heart health.  Whether you're hoping to lower your numbers, prevent future heart issues, or simply make more informed choices at the grocery store, this episode provides clear, accessible guidance on building a heart‑healthy way of eating. Chapters: 01:13 – What Do Heart Health Numbers Mean? 04:33 – How Quickly Diet Changes Improve Labs 10:59 – How to Start Changing Eating Habits Key Topics Covered What cholesterol, blood pressure, triglycerides, HDL, LDL, and ApoB measure How these numbers relate to cardiovascular disease risk Healthy ranges for blood pressure and cholesterol How diet can lower LDL cholesterol and blood pressure How quickly lab results change after modifying eating habits The role of salt sensitivity and saturated fats in heart health Foods that help lower LDL, including soluble fiber and healthy fats The DASH diet: its structure, purpose, and evidence for lowering blood pressure The Mediterranean diet: core foods, flexibility, and cardiovascular benefits Differences between DASH and Mediterranean diets Practical starting points for improving eating habits Benefits of tracking food intake and identifying patterns Easy, heart‑healthy food and snack swaps Why lifestyle factors like sleep, stress, exercise, and limiting alcohol matter Common misconceptions about eating for heart health Why heart‑healthy eating is beneficial at every age Takeaway Message Small, consistent changes to your diet and lifestyle can meaningfully improve your heart health — at any age. Understanding your numbers (like LDL, blood pressure, and ApoB) empowers you to make targeted choices, and evidence‑based eating patterns such as the DASH or Mediterranean diet can lower risk over time. Even if medications are part of your care, diet, sleep, exercise, and stress management remain essential tools for protecting your heart. Expert Guest Dr. Sean Mendez is a non-invasive cardiologist at New York Presbyterian Brooklyn-Methodist Hospital and an assistant professor of clinical medicine at Weill Cornell Medicine. His clinical interests include preventive cardiology, valvular heart disease, and cardiovascular imaging, including echocardiography, stress testing, and vascular imaging. In addition to seeing patients in his outpatient clinic, he provides inpatient care in the cardiac care unit, cardiac telemetry unit, and consultative cardiology service. Dr. Mendez is passionate about providing his patients with the highest-quality, comprehensive cardiovascular care. He addresses all aspects of health to prevent the development and progression of cardiovascular disease. Dr. Mendez, a native of Buffalo, New York, graduated magna cum laude from the University of Alabama with a bachelor's degree in both biology and mathematics. He attended medical school at the University at Buffalo, where he was inducted into the prestigious Alpha Omega Alpha Medical Society. Dr. Mendez then completed his residency in internal medicine at Massachusetts General Hospital/Harvard Medical School.  He then completed his fellowship in cardiology at the Mount Sinai Hospital, where he was chief fellow. For more health and wellness news, visit NewYork-Presbyterian's Health Matters website. 

Garlic may be one of the most powerful foods in your kitchen due to its vast health benefits. In this episode, Dr. Hana Kahleova joins Chuck Carroll to explain the science behind garlic's impact on cholesterol, blood pressure, immune function, antioxidant production, and even gene signaling. Backed by randomized clinical trials and meta-analyses, she reveals how just one clove per day may help improve cardiovascular health and reduce infection risk.

El aceite de oliva es mucho más que un ingrediente tradicional: es uno de los alimentos mejor respaldados por la ciencia nutricional. Hoy, Jorge Laborda presenta una nueva entrega del Quilo in Memoriam en el que el Dr. Francisco Grande Covián habla, con su propia voz y estilo, recuperados por inteligencia artificial, del aceite de oliva y de su importancia para la alimentación humana. Grande Covián ya mostró hace décadas que no todas las grasas actúan igual. El aceite de oliva, rico en ácido oleico, ayuda a reducir el colesterol LDL —asociado al riesgo coronario— sin disminuir el HDL, que cumple una función protectora. Además, contiene antioxidantes como polifenoles y vitamina E. El mensaje no es que sea un producto “milagroso”, sino que resulta beneficioso cuando sustituye a grasas saturadas dentro de un patrón saludable como la dieta mediterránea.

El aceite de oliva es mucho más que un ingrediente tradicional: es uno de los alimentos mejor respaldados por la ciencia nutricional. Hoy, Jorge Laborda presenta una nueva entrega del Quilo in Memoriam en el que el Dr. Francisco Grande Covián habla, con su propia voz y estilo, recuperados por inteligencia artificial, del aceite de oliva y de su importancia para la alimentación humana. Grande Covián ya mostró hace décadas que no todas las grasas actúan igual. El aceite de oliva, rico en ácido oleico, ayuda a reducir el colesterol LDL —asociado al riesgo coronario— sin disminuir el HDL, que cumple una función protectora. Además, contiene antioxidantes como polifenoles y vitamina E. El mensaje no es que sea un producto “milagroso”, sino que resulta beneficioso cuando sustituye a grasas saturadas dentro de un patrón saludable como la dieta mediterránea.

Today, I have the honor of connecting with Dave Watumull, the Co-founder and CEO of AX3 Life, a consumer health company dedicated to astraxanthin products, education, and community. Dave is on a mission to introduce the world to astaxanthin. Astaxanthin is a marine-derived super-nutrient that supports whole-body health and longevity, a pursuit that has inspired Dave for over 25 years of research, development, and commercialization. In our discussion, Dave explains what astraxanthin is, its functions, and its key properties. We explore specific studies where astraxanthin has been particularly beneficial for lipids, particularly oxidized LDL. We discuss the impact of nutrition and examine the results of astraxanthin research on sarcopenia, cognition, and joints, liver, skin, and eye health. We also cover the dose-dependent effects of astraxanthin, and Dave answers a series of rapid-fire questions. Astaxanthin is truly a supplement worth considering. I'll be taking it to see if it helps reduce my Lp(a). My husband and one of my children also have high Lp(a), so we will all try it as a family experiment, and I will share the results. IN THIS EPISODE, YOU WILL LEARN: Astaxanthin's origins and mechanisms The ideal dosing range for starting astaxanthin, and how the benefits appear even at lower doses What a dose-dependent effect actually means The importance of fundamentals like consistent sleep, a balanced, nutrient-dense diet, and daily physical activity How astaxanthin forms a protective antioxidant network The value of astaxanthin for supporting brain and ocular health How astaxanthin reduces inflammation without suppressing immunity The importance of taking astaxanthin with a meal to maximize absorption Why AX3 Astaxanthin surpasses other astaxanthin supplements Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dave Watumull AX3 Life AX3 Life on Instagram

Can a plant-based Portfolio Diet lower LDL cholesterol as effectively as statin drugs?

What if cholesterol isn't the real villain behind heart disease? In this episode, Dr. Josh Axe reveals why inflammation, insulin resistance, and oxidative stress—not just LDL—may be the true drivers of cardiovascular risk. Discover which fats actually protect your heart, the blood markers that matter most, and how to create the internal conditions where heart disease can't thrive. Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

In today's episode, we're talking about cardiovascular health. Heart disease remains the #1 threat to the quality and quantity of life for Americans. And this is not because of a metformin or statin deficiency. We are pumping these drugs out at all time highs, but have yet to make a dent in heart disease. If you are in the traditional medicinal model, you may not be privy to the fact that there are other ways of supporting and invigorating the cardiovascular system and the underlying drivers of heart disease. You can actually improve cholesterol balance, blood sugar, arterial inflammation, and vascular health with natural means. Let's talk about where to start. Two fruit extracts that can help are bergamot and amla. You know I am a big fan of fruit and these two in particular positively influence: LDL cholesterol Triglycerides HDL Insulin sensitivity Arterial stiffness Vascular Oxidative stress You can find these two science-backed fruit extracts in Cardio Supreme.   -------- Connect with Dr. Matt online:  

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Michael: Hi Dr. Cabral. I'm an IHP Level 1 and have been following you for over 2 years. I'm grateful for all you do. I'm a 61 year old male and take no medication. I've always had elevated cholesterol but it's come down a lot over the last 2 years. I now have LDL of 108. My CRP is in the normal range at 0.41. My homocysteine is also in the normal range at 8.9. My coronary calcium score from almost 3 years ago is 129. I want to make sure my heart stays healthy and want to be smart about what supplements to take apart from the foundational ones like the DNS and Omega 3. If I take all the supplements that promote a healthy heart, it gets a bit expensive and I was wondering if you thought about formulating one supplement to combine some of them. I'm currently taking D3+K2, Red Yeast Rice, Berberine and Inflamma Soothe, and I'm considering adding in Proteolytic Enzymes. What are your thoughts on which ones to prioritize?      Lily: Hi Doc, I am taking the foundational supplements and magnesium. I know that everyone is different and the personal approach is best (I just ordered your new book). But, if you had to say, beyond the foundational supplements, what are your next 4 favorite supplements?      Tommy: Hi Dr C, I'm An IHP 2. I've come a long way with my health and career thanks to you. I've had many issues in life similar to you. In the last 2 years I feel like I've become very prone to gut issues. I've done 2 para and 1 CBO in the last year. I seem to get bouts of dhiarrea like I've picked up a bacteria. I have wondered if my stomach acid is low, being an online presence is stressful, but I'm working on my stress more than ever. What else could cause me to have a 'weak stomHawkins: ach'? I still get anal itching too, sometimes during the day, I know you've mentioned this could also be histamines and not just parasites. I've had so much trauma, antibiotics, and 14 years of steroid creams. I've had low cortisol too which I believe is much better now.      Scott: Hi Stephen. (Scott UK) . My wife had a routine operation (9 operations in total) and ended up with stomach problems diagnosed with gastroparesis, well that's what they said, she ended up with a feeding tube and an ileostomy, in the last couple of years she's really turn thing around she's back to solid food and she hasn't fed on her feeding tube for 9 to 10 months now, she's gaining weight and looking really healthy, she's 53 and going through menopause, she's been diagnosed with carpal tunnel and trigger finger in both hands, and both thumbs are now stuck straight, she takes half of a scoop of DNS and greens powder, D3k2. magnesium, zinc, omega 3, infrared sauna, red light, 7000 steps, they want to operate on both hands,which I'd like to avoid, any suggestions would be very helpful.      Stephanie: Hi! I had a full work up done and it showed my prolactin level is 95. CRP also elevated, but everything else within range. I am willing to go see an endocrinologist, but I am hesistant to take the cabergoline (I've read that's likely how they will proceed). Is there anything else I can do? I started taking Vitex Berry when I got the results.      Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3669 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Apoprotein B provides a virtual count of the lipoprotein particles in the bloodstream that cause coronary heart disease. It is often held up as superior to the widely used LDL cholesterol value. Is this true?It is true, but it does not mean that measuring apoprotein B tells you much about health. Compare this to the enormous amount of insight provided by measuring the REAL cause of heart disease: small LDL particles that gives you an entire universe of insight into your overall health, as well as risk for heart disease. And it is wonderfully and completely manageable with some simple strategies. Support the showYouTube channel: https://www.youtube.com/@WilliamDavisMD Blog: WilliamDavisMD.com Membership website for two-way Zoom group meetings: InnerCircle.DrDavisInfiniteHealth.com Books: Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

Dr. Malcolm Kendrick challenges the prevailing lipid hypothesis regarding heart disease, arguing that the relationship between cholesterol, particularly LDL, and heart disease is not as straightforward as commonly believed. He discusses the role of saturated fats, the importance of nitric oxide, and the impact of lifestyle factors on cardiovascular health. Kendrick also critiques the research surrounding statins, emphasising the need for transparency and the potential biases in studies that downplay adverse effects. The discussion highlights the complexity of heart disease and the necessity for a broader understanding of its causes and treatments.Chapters00:00 Introduction to Dr. Malcolm Kendrick00:42 Challenging the Lipid Hypothesis02:19 Saturated Fat and Heart Disease04:21 Understanding Cholesterol and Its Role07:48 Observational Studies vs. Randomized Trials10:59 The Failure of Statins and Other Drugs11:44 The Black Swan Argument in Medicine16:20 Familial Hypercholesterolemia Explained17:40 The Role of Blood Clotting in Heart Disease25:50 The Ghost in the Machine: Revisiting Old Theories36:55 The Interconnection of Blood Clotting and Immunity40:47 Understanding Endothelial Damage and Heart Disease45:59 The Role of Sickle Cell Anaemia and Autoimmune Diseases48:34 COVID-19: Blood Clots and Immune Response51:11 Critique of Statin Research and Adverse Effects

February is Heart Health Month, making it the perfect time to challenge common misconceptions about diet and cardiovascular health.One claim that always resurfaces? That ketogenic diets are bad for your heart. But when you take a closer look at the science, that assumption simply doesn't hold up.In this video, Dr. Bret Scher breaks down the real evidence behind ketogenic diets and cardiovascular risk, addressing:✅ How many “keto” studies don't actually study true ketogenic diets✅ The truth about LDL cholesterol on keto (it doesn't go up for everyone!)✅ Why triglycerides, HDL, insulin, and inflammation may matter more than LDL✅ How keto compares to DASH for blood pressure and metabolic health✅ Why saturated fat from real food behaves differently in the body✅ The critical difference between ultra-processed high-fat/high-carb diets and low-carb, whole-food ketogenic diets

What if you could dial back your biological age – not through expensive treatments or extreme diets – but with surprisingly simple habits that longevity doctors actually use themselves? Dr Harpal Bains joins Liz to reveal the practical strategies that could genuinely add years to your life.In this episode:Why your heart, cells and organs could all be different agesThe pulse wave velocity test revealing arterial stiffness before symptoms appearThe impact of stress on heart health and longevityHow much exercise is too much? The truth about LDL cholesterol and oxidative stressMicrodosing GLP-1 medications for longevity (not just weight loss)HRT as a longevity strategy beyond symptom reliefThe 70% rule and why joy might be the most powerful pro-ageing toolLinks mentioned in the episode:GlycanAge testListen to Liz's previous conversation with HarpalMore from Liz:Preorder Liz's new book – How to AgeA Better Second Half Follow Liz on InstagramFollow Liz Earle Wellbeing on InstagramMore from Harpal:Harpal ClinicFollow Harpal on InstagramGet in touch with a question for Liz:Email: podcast@lizearlewellbeing.comWhatsApp: 07518 471 846Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

Is cholesterol bad? Is low cholesterol safe? In this video, we'll cover common cholesterol misinformation, how cholesterol was demonized, and the cholesterol truth you need to know now for better health.

In this episode, we explore several important non-statin cholesterol-lowering therapies, focusing on their mechanisms, clinical uses, and practical considerations for patient care. We start with bile acid sequestrants, also known as resins, including cholestyramine, colestipol, and colesevelam. These medications lower LDL cholesterol by binding bile acids in the gut, prompting the liver to use more cholesterol to make new bile acids. They are effective for LDL reduction but may cause gastrointestinal side effects and have drug interaction considerations. Next, we cover niacin (vitamin B3), which can lower LDL and triglycerides while raising HDL cholesterol. While niacin was historically widely used, its role has declined due to flushing, gastrointestinal symptoms, and potential liver toxicity. Omega-3 fatty acids, including icosapent ethyl (EPA), primarily lower triglycerides and are used in patients with severe hypertriglyceridemia to reduce the risk of pancreatitis. Icosapent ethyl is a purified EPA formulation with evidence of cardiovascular benefit in select high-risk patients. Finally, we discuss bempedoic acid, a newer oral agent that inhibits ATP-citrate lyase in the liver. Because it is activated only in the liver, bempedoic acid may be useful for patients with statin-associated muscle symptoms. Common adverse effects include elevated uric acid and mild increases in liver enzymes. This episode highlights how these non-statin agents can be strategically used alone or in combination with other therapies to help patients reach their lipid goals and reduce cardiovascular risk. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

852. Fermented dairy may affect cholesterol differently than butter or processed meats—but it's not a free pass. Here's what the evidence actually shows about yogurt, cheese, saturated fat, and LDL cholesterol.ReferencesDairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned? - PMCMilk and Dairy Product Consumption and Cardiovascular Diseases: An Overview of Systematic Reviews and Meta-Analyses - ScienceDirectEffect of cheese consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials - PubMedHarnessing the Magic of the Dairy Matrix for Next-Level Health Solutions: A Summary of a Symposium Presented at Nutrition 2022Dairy and Cardiovascular Disease: A Review of Recent Observational Research - PMCFermented dairy product consumption and blood lipid levels in healthy adults: a systematic reviewNew to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age. Have a nutrition question? Send an email to nutrition@quickanddirtytips.com.Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find out about Monica's keynotes and other programs at WellnessWorksHere.comNutrition Diva is a part of the Quick and Dirty Tips podcast network.   New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age. Have a nutrition question? Send an email to nutrition@quickanddirtytips.com.Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find out about Monica's keynotes and other programs at WellnessWorksHere.comNutrition Diva is a part of the Quick and Dirty Tips podcast network. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Hour 1 for 2/18/26 Dr. Sean O'Mara joined Drew to discuss the physical benefits of fasting (1:00). Topics: major fasts (8:30), carnivore diet (19:32), muscle mass (31:49), LDL issues (39:41), black coffee (43:46), and biohacking (46:11). Links: https://drseanomara.com/ Original Air Date: 3/5/25

Today, I am excited to share the first class in a series of lipid masterclasses with the amazing Dr. Thomas Dayspring! Dr. Dayspring is certified in internal medicine and clinical epidemiology and is a fellow of the American College of Physicians and the National Lipid Association. He was previously the Educational Director of a nonprofit organization and has served as the Chief Academic Advisor for two major cardiovascular labs.  Given the in-depth nature of my discussions with Dr. Dayspring over several sessions, each lasting nearly six hours, it seemed logical to present these masterclasses in segments to make them easier to understand. In our first class today, we dive into the fundamentals, exploring what lipids are and how lipids and fatty acids are classified. We cover the physiology and transport of cholesterol and the roles of apoptosis, apo-proteins, and apo-lipoproteins; we unravel the differences between HDL, LDL, IDL, and VLDL; and we explain how to calculate LDL and triglycerides to assess metabolic health. Dr. Dayspring also shares his preferences regarding lab values and indicators that help him assess the early risk of cardiovascular disease. We cover some detailed aspects of physical chemistry in this episode, so I highlight the main clinical points throughout our conversation to make it easier to follow. Be sure to join Dr. Dayspring and me for our next episode in the lipid masterclass series. IN THIS EPISODE YOU WILL LEARN: What are lipids, and why are they important? Dr. Dayspring explains what triglycerides are. How lipids get absorbed and transported throughout the body What lipoproteins are, and how they get classified How cholesterols get calculated The impact of triglycerides on cholesterol levels and cardiovascular health How high triglyceride levels can indicate early insulin resistance or increased ASCVD risk What is the role of HDL particles? How metabolic syndrome impacts cardiovascular health Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, he moved to Virginia in 2012. He served as an educational director for a nonprofit cardiovascular foundation and, until mid-2019, as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular / lipidology educator. Career-wise he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women's cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years, he was an Associate Editor of the Journal of Clinical Lipidology. He was the recipient of the 2011 National Lipid Association's Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association and serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Thomas Dayspring ⁠Twitter⁠ (@DrLipid) ⁠LinkedIn⁠ ⁠Books written by Gary Taubes⁠ 

In this pharmacology podcast episode, we focus on two key non-statin cholesterol-lowering therapies: ezetimibe and PCSK9 inhibitors (Click here to listen to the statin podcast episode). These agents play a role in lipid management, particularly for patients who are unable to reach LDL cholesterol goals with statins alone or who have statin intolerance. Ezetimibe works by inhibiting the absorption of dietary and biliary cholesterol at the brush border of the small intestine. By reducing the amount of cholesterol delivered to the liver, ezetimibe lowers circulating LDL cholesterol by approximately 15 to 25 percent. It is taken orally once daily and is commonly used as add-on therapy to statins in patients with established atherosclerotic cardiovascular disease or high baseline LDL levels. Ezetimibe is generally well tolerated, with a favorable safety profile and minimal systemic exposure, making it an attractive option in older adults and patients with multiple comorbidities. PCSK9 inhibitors, including alirocumab and evolocumab, offer a much more potent LDL-lowering effect. These monoclonal antibodies work by blocking PCSK9, a protein that promotes degradation of LDL receptors in the liver. By preserving LDL receptors, PCSK9 inhibitors enhance clearance of LDL cholesterol from the bloodstream, often reducing LDL levels by 50 to 60 percent. They are administered via subcutaneous injection every two to four weeks and are most commonly used in patients with familial hypercholesterolemia, established cardiovascular disease, or persistently elevated LDL despite maximally tolerated statin and ezetimibe therapy. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101