Podcasts about tirzepatide

In this episode of the Irresistible You podcast, we're diving into what it means to embrace your cozy or “soft life” era, without the guilt. I used to think that doing cozy things like diamond painting or relaxing at home was lazy… or worse, that stillness would lead to weight gain. I thought if it didn't make money or burn calories, it was a waste of time. But now I know better.I'm sharing how I've started doing things that pull me rather than constantly pushing myself and how that shift has helped me stop emotional eating, feel more grounded, and finally listen to my body. Cozy isn't laziness, it's restoration.If you've ever felt stuck between hustle culture and burnout, this episode is for you.

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro  00:02:40 Personal Life Updates  00:04:51 Pregnancy and Lifestyle Changes  00:10:57 Early Steroid Use and Coaching  00:18:43 Sleep Schedules and Productivity  00:26:45 Bodybuilding Industry Evolution  00:27:52 Modern Bodybuilding Aesthetics  00:37:31 GLP-1 Agonists and Nutrition  00:41:37 Classic Physique and Weight Caps  00:46:51 Coaching and Knowledge Evolution  00:53:07 Family Genetics and Hard Work  00:56:55 Diminishing Returns With Protein  01:08:23 Growth Hormone Dosing Insights  01:16:41 Insulin and GH Combinations  01:22:54 Elite Coaching and Drug Testing  01:27:17 Insulin Resistance Myths  01:32:30 Social Media Arguments01:34:38 Trenbolone and Kidney Concerns  01:39:30 Smart Drug Choices in Bodybuilding  01:49:55 Living In Thailand01:56:35 HGH Timing 02:06:30 Tirzepatide vs. Retatrutide  02:12:00 Prescriptions and Traveling02:16:58 Reversing LVH Growth  02:22:42 Estradiol Levels on Cycle  02:27:04 Anabolic Synonymous Shutdown02:30:45 Classic Physique Drug Use 02:33:40 Life Updates and Fatherhood

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In this episode, I sit down with returning guest Dr. Gabby Gerbino to dig deeper into GLP-1 medications like Ozempic and Tirzepatide. We talk about the side effects most people don't hear about, what to do if you're not responding to the meds, and why sustainable weight loss isn't about eating less—it's about doing things right. If you or someone you love is considering or currently using GLP-1s, this episode will help you navigate your journey with better questions, better strategy, and way less misinformation.HOW TO FIND DR. GERBINO:Book An Appointment: https://www.zocdoc.com/doctor/gabrielle-gerbino-md-552785?fbclid=IwZXh0bgNhZW0CMTAAAR1q4mVKJOAdejs0ItOa-AEImDKXZFdSwrYji-cKVLOlYUeMo98CUCXQ1ls_aem_ZFil8u0r_hDBLVr34hW3EgFIT40 LINKS✅ Want some free workouts to get you started on your fitness journey?Check out the FIT40 Toned In 20 Workouts by clicking here: https://fit40coaching.com/20✅ Do you thrive on monthly challenges and group support?Check out FIT40 Group Coaching by clicking this link: https://coach.everfit.io/package/BG758131​✅ Need professional level 1:1 accountability to help you finally reach your goals?Check out FIT40 Coaching by clicking this link: https://fit40coaching.com/AFFILIATE LINKS:Try Tonal for 30 Days Risk Free: https://tonal.sjv.io/FIT40Get 10% Off The Genius Protein Shot: https://www.geniusshot.com/?ref=BRYAN_FIT40&transaction_id=10214dd14c839e450a4423af7b1f8eCONNECT WITH ME ONLINEFacebook: https://www.facebook.com/bryan.fitzsimmonsInstagram: ⁠⁠⁠⁠https://www.instagram.com/coach_fitzz/⁠⁠⁠⁠Tiktok: ⁠⁠⁠⁠⁠https://www.tiktok.com/@coach_fitzz?is_from_webapp=1&sender_device=pcYoutube: https://www.youtube.com/@bryan_fit40 This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit bryanfitzsimmon.substack.com

Kann man den Hunger einfach wegspritzen? Und was passiert eigentlich, wenn du plötzlich keinen Appetit mehr hast?Die Medien sind voll von Mythen, Halbwissen und Marketing rund um Ozempic, Wegovy und anderen der sogenannten „Abnehmspritzen“. In dieser Episode bekommst du den Überblick, den du brauchst – um Dir eine eigene Meinung zu bilden.Du erfährst:warum viele Menschen nicht zunehmen, obwohl sie mehr essen – und andere schon bei normalen Portionen zunehmen,was GLP-1-Wirkstoffe mit Spielsucht, Alkohol und impulsivem Verhalten zu tun haben,warum viele Patienten nach dem Absetzen der Spritze schneller wieder zunehmen, als sie abgenommen haben,und warum es gefährlich sein kann, unter diesen Medikamenten zwar Gewicht zu verlieren – aber dabei Muskeln zu verbrennen statt Fett.Und wenn Du ohnehin sagst: „Spritze? Kommt für mich nicht infrage“, lohnt diese Episode – weil sie Dir hilft, den Mechanismus hinter Hunger, Sättigung und Gewohnheiten besser zu verstehen. Und damit auch Deinen eigenen Körper effektiver zu steuern.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Mehr zum Thema:Podcast: Folge 502: Ratgeber Nahrungsergänzung – mit Ernährungsmediziner Niels Schulz-RuhtenbergQuellen:Wilding, J. P. H. et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002.Garvey, W. T. et al. (2022). Two-year effects of semaglutide in adults with overweight or obesity: The STEP 5 trial. Nature Medicine, 28(10), 2083–2091.Jastreboff, A. M. et al. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205–216.Ryan, D. H. & Yockey, S. R. (2017). Weight loss and improvement in comorbidity: Differences at 5%, 10%, 15%, and over. Current Obesity Reports, 6(2), 187–194.Marx, N. et al. (2022). GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes. Circulation, 146(24), 1882–1894.Lincoff, A. M. et al. (2023). Semaglutide and cardiovascular outcomes in obesity without diabetes. New England Journal of Medicine, 389(24), 2221–2232.Karakasis, P. et al. (2023). Effect of tirzepatide on renal function in type 2 diabetes: A systematic review. Diabetes, Obesity and Metabolism.Ida, S. et al. (2021). Effects of antidiabetic drugs on muscle mass in type 2 diabetes mellitus. Current Diabetes Reviews, 17(3), 293–303.Wilding, J. P. H. et al. (2021). Impact of semaglutide on body composition in adults with overweight or obesity: Exploratory analysis of the STEP 1 study. Journal of the Endocrine Society, 5(Suppl. 1), A16–A17.Gorgojo-Martínez, J. J. et al. (2022). Clinical recommendations to manage gastrointestinal adverse events in patients treated with GLP-1 receptor agonists: A multidisciplinary expert consensus. Journal of Clinical Medicine Research, 12(1).Tantawy, S. A. et al. (2017). Effects of physical activity and diet control to manage constipation in middle-aged obese women. Diabetes, Metabolic Syndrome and Obesity, 10, 513–519.Jastreboff, A. M. et al. (2023). Triple–hormone-receptor agonist retatrutide for obesity — A phase 2 trial. New England Journal of Medicine, 389(6), 514–526.***Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

What do Zumba and Greek dancing have to do with bone density? Why should you shave first and soak later? And who gets to decide whether you can have a hysterectomy for health reasons if you haven’t had kids yet? In this episode, Endocrinologist Dr Sonia Davison from Jean Hailes for Women’s Health talks about whether diet and exercise can prevent dementia and what waist circumference has to do with healthy ageing. She also discusses how stomping, sleeping and strength training should all be part of the puzzle as you get older. We also talk about intermittent fasting and how cups of tea with your girlfriends could be just what the doctor ordered. And, is it possible to delay your ‘hormone window of chaos’? THE END BITS For more information on bone density Dr Sonia Davison recommends: Healthy Bones Australia For more information on fibroids Dr Mariam recommends: ask4ufe Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can send it anonymously here, email here or leave us a voice note here. Ask The Doc: Ask us a question in The Waiting Room. Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriberCREDITS Hosts: Claire Murphy and Dr MariamGuest: Dr Sonia DavisonSenior Producers: Claire Murphy and Sasha TannockAudio Producer: Scott Stronach Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well. is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.See omnystudio.com/listener for privacy information.

Is there a better, safer, FREE alternative to Ozempic (and other GLP-1 drugs)? In this episode of Walk, Don't Run to the Doctor, Miles Hassell MD reacts to the growing buzz and shares a time-tested, evidence-based 3-step plan that outperforms popular weight loss drugs in the long run. As GLP-1 drugs like Ozempic, Wegovy, and Mounjaro surge in popularity, Dr. Hassell offers critical insight into their risks—like muscle loss, pancreatic complications, and long-term unknowns—while proposing a practical, natural alternative for lasting weight loss and better metabolic health. Key Takeaways: Why Big Pharma's track record with weight loss drugs demands caution The secret 3-step plan: Eat 6 servings of fruits & veggies, 3 minutes of daily exercise, reduce refined carbs Bonus tips: Bust cravings by eating protein with every meal, daily probiotics, and unlock the power of preemptive eating Why this plan costs nothing, has zero side effects, and starts showing results in just one week A timely message in light of the weight loss drug headlines—who should be in control of your health?  More references can be found at www.GreatMed.org Get your copy of Good Food Great Medicine. https://a.co/d/ajAzYzo Would you like Dr. Hassell to answer your question on the air? Contact us! Phone/text: 503-773-0770 e-mail: info@GreatMed.org Write us a letter. We love to hear from you. This podcast is sponsored by our generous listeners. Send questions, comments, and support to: 4804 NW Bethany Blvd., Suite I-2, #273 Portland OR 97229 References: Chen, X., et al. (2025). Association of dietary fiber intake with all-cause and cardiovascular mortality in diabetes and prediabetes. Diabetology & metabolic syndrome, 17(1), 231. https://pubmed.ncbi.nlm.nih.gov/40533827/   Look, M., et al. (2025). Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight. Diabetes, obesity & metabolism, 27(5), 2720–2729. https://pubmed.ncbi.nlm.nih.gov/39996356/   Wilding, J., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England journal of medicine, 384(11), 989–1002. https://pubmed.ncbi.nlm.nih.gov/33567185/   Tinsley, G. M., & Heymsfield, S. B. (2024). Fundamental Body Composition Principles Provide Context for Fat-Free and Skeletal Muscle Loss With GLP-1 RA Treatments. Journal of the Endocrine Society, 8(11),https://pubmed.ncbi.nlm.nih.gov/39372917/    Neeland, I. J., et al. (2024). Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes, obesity & metabolism, 26 Suppl 4, 16–27. https://pubmed.ncbi.nlm.nih.gov/38937282/   Sato, M., et al. (2023). Relationships among Postprandial Plasma Active GLP-1 and GIP Excursions, Skeletal Muscle Mass, and Body Fat Mass in Patients with Type 2 Diabetes Treated with Either Miglitol, Sitagliptin, or Their Combination: A Secondary Analysis of the MASTER Study. Journal of clinical medicine, 12(9), 3104. https://pubmed.ncbi.nlm.nih.gov/37176545/   Monami, M., et al. (2017). Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Diabetes, obesity & metabolism, 19(9), 1233–1241. https://pubmed.ncbi.nlm.nih.gov/28244632/   Anderson, S. L., & Trujillo, J. M. (2010). Association of pancreatitis with glucagon-like peptide-1 agonist use. The Annals of pharmacotherapy, 44(5), 904–909. https://pubmed.ncbi.nlm.nih.gov/20371755/   Kapoor, I., Sarvepalli, S. M., D'Alessio, D., Grewal, D. S., & Hadziahmetovic, M. (2023). GLP-1 receptor agonists and diabetic retinopathy: A meta-analysis of randomized clinical trials. Survey of ophthalmology, 68(6), 1071–1083. https://pubmed.ncbi.nlm.nih.gov/37454782/   Bikou, A., et al. (2024). A systematic review of the effect of semaglutide on lean mass: insights from clinical trials. Expert opinion on pharmacotherapy, 25(5), 611–619. https://pubmed.ncbi.nlm.nih.gov/38629387/   Jalleh, R. J., et al. (2024). Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide. The Journal of clinical endocrinology and metabolism, 110(1), 1–15. https://pubmed.ncbi.nlm.nih.gov/39418085/   Berg, S. AMA. (2023). Questions patients may have about weight-loss drugs. https://www.ama-assn.org/delivering-care/public-health/questions-patients-may-have-about-weight-loss-drugs   Friedman, J. (2025). America's up-and-down history with weight-loss drugs. https://www.history.com/articles/weight-loss-drugs-america    

On May 11, 2025, the study “Tirzepatide as Compared with Semaglutide for the Treatment of Ob*sity” was published in the New England Journal of Medicine.This study was, essentially, a cage match between the two newest weight loss drugs to see which one created more weight loss. Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

Are you navigating the stormy seas of menopause? Wondering how to tackle bloating and breakthrough bleeding? Curious about the mysteries of hormone therapy and why traditional treatments may not work for everyone? This second-part Q&A episode is packed with real-life stories and expert advice to answer your questions! Ever wondered how hormone levels, thyroid function, and gut health intertwine during menopause? What about the innovative strategies that can help with weight loss resistance? Discover why personalized solutions are key to thriving through hormonal shifts and learn how to biohack your way to better health. From managing stress-induced hormone fluctuations to the unexpected role of melatonin, this episode has it all. What adjustments can you make to your hormone replacement therapy during stressful times? And how can peptides help in your weight loss journey? Dive into these topics and more! In this episode, we uncover: How hormone imbalances can cause bloating, plus how to address them effectively. Why personalized hormone therapy is crucial for women with unique health challenges. How innovative peptides can help overcome weight loss resistance and enhance results. Why adjusting hormone therapy during stress is vital for managing menopause symptoms. How melatonin plays a multifaceted role in menopause beyond just aiding sleep. Don't miss out on these transformative insights. Tune in now to empower your journey through menopause and discover solutions that truly work for you!     Sponsors Get our Estro Vitality and Progest Sleep Hormone Oils and get 25% off. Coupon KM20 to get 20% off your order of Vitali Skin Care! Use my link to save 20% at GETKION.COM/HORMONE     Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada.   Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs  Peptide Therapy for weight loss    Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here.   Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY!   To our nursing audience members, our podcasts qualify for nursing CE @ RNegade.pro. Provide # CEP17654.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we're diving into a topic that's been everywhere lately: GLP-1 medications like semaglutide and tirzepatide for weight loss. You may know them by names like Wegovy, Ozempic, Mounjaro, or Zepbound. I want to give you a clear, realistic picture of what to expect—because while the media loves to highlight the dramatic before-and-after photos, the real journey can be slower and more nuanced for some. So in this episode, we're going to talk about the truth—what these medications can do, what they can't, how long things really take, and what you need to know to set yourself up for success. Not hype, not magic promises—just real, honest insight to help you understand the process. Let's get into it. How GLP-1 & GIP/GLP-1 Agonists Work So first things first—how do these meds work? Semaglutide is a GLP-1 receptor agonist, and tirzepatide is a dual GIP and GLP-1 receptor agonist. Basically, they mimic natural hormones in your body that help regulate blood sugar, slow digestion, and—most importantly for weight loss—reduce appetite and improve satiety. That means you feel fuller faster and stay full longer. You're not obsessing over food like before. And that's powerful. But—and this is a big one— these peptides don't magically erase years of weight gain overnight. What they do is help make weight loss easier by reducing hunger and supporting your metabolism—but they don't do all the work for you. It's important to remember they're a powerful tool, not a replacement for your efforts. You're still in control of your choices, habits, and long-term success. Why We Titrate the Dose—and What "Therapeutic Dose" Means Now, let's talk about dosing. When you start Wegovy, you don't start at the highest dose. It's gradually increased over several weeks to give your body time to adjust and to help reduce side effects like nausea or stomach upset. The usual schedule looks like this: You'll start with 0.25 mg once a week for the first month. Then it increases every four weeks—0.5 mg, then 1 mg, then 1.7 mg. By week 17, most people reach the full dose of 2.4 mg once a week—that's the dose shown in studies to lead to the most consistent weight loss, with many people losing around 15% of their total body weight over about a year. But here's the thing—not everyone follows this path exactly, and that's okay. Some people need to slow down or stay longer at a lower dose if they're having side effects. Others may need to increase sooner if they're not seeing appetite changes and are tolerating the medication well. And even though 2.4 mg is considered the “therapeutic dose,” not everyone needs to reach it. Some people feel great and lose weight at a lower dose—and if that's you, that's your sweet spot. The real goal is to find the lowest effective dose that controls your hunger, helps you lose weight at a steady pace, and keeps side effects to a minimum. This isn't a one-size-fits-all journey, and pushing through side effects just to hit the max dose isn't necessary—or safe. Your best dose is the one your body handles well and helps you make progress. *How Much Weight Can You Expect to Lose—and How Fast? Let's take a look at the clinical studies. In large trials, people on semaglutide lost about 15% of their total body weight over 68 weeks. For tirzepatide, it was even higher—20% or more in some cases. But here's the thing—those results happened over a year to a year and a half. Not 6 weeks. Not 3 months. It's a marathon, not a sprint. Also, most of the weight loss doesn't happen during the titration phase. You may see some weight loss early on, especially if your appetite plummets. But the bulk of the weight loss happens once you reach and maintain your therapeutic dose. Why Everyone's Journey Looks Different I can't stress this enough—everybody's journey is different. Some people feel zero hunger from their very first injection. Others don't notice a big change until week 10 or 12. Some drop 10 pounds in the first month. Others lose two pounds and feel discouraged. All of those experiences are normal. Your age, hormones, medications, stress levels, sleep, and past diet history? They all play a role. And let's be real—gaining 20, 50, or 100 pounds didn't happen in a few weeks, right? It likely took months or even years of lifestyle habits, hormonal shifts, emotional eating, or underlying conditions. So we have to give ourselves that same grace and patience when we're trying to take the weight off—even with medical support. Navigating Side Effects and Setbacks Let's talk about the side effects. Nausea, constipation, acid reflux, bloating—yeah, these are pretty common as your body adjusts. And sometimes, those symptoms are your body's way of saying: Hey, slow down. Pushing through intense side effects just to hit a higher dose isn't the goal. In fact, it's not safe. You want the lowest effective dose that keeps your appetite under control, the weight coming off gradually, and your side effects minimal or nonexistent. If you need to pause treatment to let your gut settle or even go back down a dose, that's not failure. That's smart, safe self-care. We're in this for the long haul. Trial and Error with Food—and That's OK One part of this journey that catches people off guard is how sensitive your stomach becomes—especially to certain foods or drinks. Greasy or fried foods, spicy meals, carbonated drinks, alcohol—these can all be triggers for nausea or even vomiting while you're on this medication.  And it makes sense when you think about it: the medication slows down how quickly food and drink leave your stomach. So if you're eating or drinking things that already tend to irritate the stomach lining, the effects can hit harder and last longer. Even if those foods didn't bother you before starting treatment, they might now. It's just one of those things your body has to adjust to, and it may take some trial and error to figure out what still works for you. What is Healthy, Sustainable Weight Loss? So what's a healthy pace of weight loss? In general, 1 to 2 pounds per week is considered safe and sustainable. But on GLP-1s, that might vary. Some weeks you may lose 3 pounds. Some weeks, nothing. And guess what? That's normal. You're looking for overall downward trends, not perfection. The goal here is steady, sustainable fat loss—not dropping weight so quickly that you feel miserable, drained, or start losing muscle. Remember, we're not chasing “skinny”—we're aiming for strong, lean, energized, and healthy. And I know we've talked about this before, but it's worth repeating: exercise is not optional when you're on a GLP-1. It's a must. When you lose weight, you lose both fat and muscle. If you're not actively working to maintain or build muscle, you risk becoming weaker and slowing down your metabolism in the process. We want to keep the muscle you have—and ideally, build more—so your body stays strong and your results last. What Is a “Non-Responder”? Now let's touch on something important: what if the medication doesn't seem to work? Let's talk about what it means to be a “non-responder” on a GLP-1 medication like Wegovy or Zepbound. In clinical terms, a non-responder is someone who has been on their therapeutic dose for at least 3 months and has lost less than 5% of their total body weight—even though they're taking the medication correctly and making lifestyle changes like adjusting their diet, increasing physical activity, and managing stress or sleep. Let's break that down with an example: If someone weighs 200 pounds, 5% of their total body weight would be 10 pounds. So if they've been on their therapeutic dose for 12 weeks and have only lost, say, 4 or 5 pounds—despite doing everything right—they may be considered a non-responder. But as we mentioned before, everyone's therapeutic dose may be different. The therapeutic dose isn't just the maximum dose like 2.4 mg of semaglutide or 15 mg of tirzepatide. It's the dose at which you personally begin to experience consistent appetite suppression, weight loss, and minimal side effects. For some people, that may happen at 1 mg of semaglutide. Others may not feel much of a difference until they reach the full 2.4 mg. Some may even respond better at 1.7 mg and not tolerate the higher dose at all. That's why we titrate slowly, monitor your symptoms, and assess both how you feel and how your body is responding. So how do we know if you've reached your therapeutic dose? We look at things like: Has your appetite significantly decreased? Are you noticing earlier fullness or fewer cravings? Are you losing weight consistently over time Are side effects tolerable or nonexistent? If the answer is yes, you're probably at your therapeutic dose. But if the answer is no—if your hunger hasn't changed much, the scale hasn't moved, and you're not noticing any shift in your eating patterns after 3 months on a stable, higher dose—it might be time to re-evaluate. That could mean adjusting the dose, checking for other health issues that might be interfering (like thyroid problems or certain medications), or even considering a different treatment approach. *So what are my final thoughts?  Your journey is unique. Not everyone responds the same way, and that's okay. The key is finding what works for your body, not just what the label says. These medications can absolutely change lives. But they're not magic. They work with your efforts—not instead of them. You'll need to be patient, flexible, and kind to yourself along the way. You may need to tweak your dose, change your food choices, or give your body time to adjust. That's part of the process. And remember—this isn't just about weight loss. It's about reclaiming your health, confidence, and energy. So take it one step at a time. Celebrate every win. And know that slow progress is still progress. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, be patient, and keep showing up for yourself. And as always, have a happy, healthy week.

GLP-1s can do wonders, but optimizing diet and exercise to the mix maximized their impact. Discover how lifestyle changes can supercharge your results.   APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com

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Welcome back to Diamond Paint and Podcast — where I ramble, reflect, and real-talk my way through a diamond painting session.In this episode, we're all over the place in the best way possible. I'm chatting about:The “Donut Mom” at cheerleading

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Today, we're taking a close look at 5-Amino-1MQ—a compound gaining attention for its potential to improve fat loss, metabolic health, and longevity. We'll break down how it works, the science behind it, and what that could mean for your health. Let's get started. So, What Is 5-Amino-1MQ? Now, just to clear something up—5-Amino-1MQ isn't actually a peptide. A lot of people assume it is because it's often talked about alongside peptides like semaglutide or BPC-157, but it's actually a small molecule compound. Its full name is 5-Amino-1-methyl-quino-linium—yeah, a bit of a mouthful—and it's designed to block an enzyme called NNMT. By doing that, it helps keep more NAD⁺ available in your cells, which is a big deal for energy production and metabolic health. It was originally developed in the world of metabolic research. Scientists were exploring ways to improve insulin sensitivity and reduce fat accumulation—especially the dangerous kind, visceral fat. So, while it plays in the same space as peptides when it comes to benefits—like fat loss, energy, and longevity—it's a totally different kind of compound. Think of it more like a targeted metabolic activator than a signaling peptide. Before we move on, I want to talk about visceral fat for a bit.  Visceral fat is the fat that builds up deep inside your abdomen, around your internal organs like your liver, pancreas, and intestines. It's different from the fat you can pinch under your skin—like on your belly or thighs. That's called subcutaneous fat. Now, why is visceral fat a problem? Because it's metabolically active, which means it doesn't just sit there—it releases hormones and inflammatory chemicals that can mess with your body's systems. High levels of visceral fat are linked to things like insulin resistance, high cholesterol, high blood pressure, and a greater risk of type 2 diabetes, heart disease, and even certain cancers. So even if someone looks slim on the outside, having too much visceral fat on the inside can still be dangerous for their health. *What Is NNMT and Why Do We Want to Block It? Let's Talk About The Science. NNMT stands for nicotinamide N-methyltransferase.  This enzyme tends to be more active in people who are overweight or have metabolic issues. When that happens, it uses up a lot of something called NAD⁺—a compound your cells need to create energy, especially in the mitochondria, which are like the power plants of your cells. So when NNMT levels go up, here's what tends to happen: You end up with less NAD⁺, your metabolism slows down, your body stores more fat, and your cells just don't have the same energy or resilience. That's where 5-Amino-1MQ comes in. It blocks NNMT, helping your cells hold onto more NAD⁺—and that changes everything. The Metabolic Benefits of Blocking NNMT *So what happens when you increase NAD⁺ inside your cells? Well, in studies—especially in animal models—5-Amino-1MQ led to: Fat breakdown and reduced fat accumulation Improved insulin sensitivity A 30% drop in cholesterol levels And get this—mice lost 5% of their body weight in just 11 days, without changes to diet or exercise. And here's the kicker—no signs of toxicity or behavioral changes. No weird side effects. Just better metabolic function. Muscle Preservation & Longevity Pathways *One of the most promising things about 5-Amino-1MQ goes beyond fat loss—it's what it could mean for preserving muscle. Blocking NNMT might actually help you keep your muscle while you're losing fat. That's a big deal—especially if you've ever tried to drop weight and felt like you were losing strength along with it. This is important because most weight loss methods cause you to lose both fat and muscle, which can slow your metabolism and reduce strength. Preserving muscle while burning fat helps you maintain energy, performance, and long-term metabolic health. There's also some solid evidence it can boost muscle performance and endurance, which tracks when you think about how it raises NAD⁺. And because NAD⁺ is involved in things like cell repair, mitochondrial function, and longevity pathways like sirtuin activation, you're not just burning fat—you're potentially supporting healthy aging and helping your body work more efficiently overall. Oral vs Injectable 5-Amino-1MQ: What's the Difference? People often ask me, “Should I take 5-Amino-1MQ as a pill or go with injections?” Here's the deal, the injectable version gets into your system faster and starts working a bit quicker. On the other hand, the oral version takes a little longer to kick in, but it's way more convenient—just take a capsule and you're good. No needles, no fuss. And honestly? Most people say they feel the same benefits either way—whether it's fat loss, energy, or mood. So unless you're looking for super fast absorption, oral works great for most people. Wrapping It Up: Why This Matters To recap—5-Amino-1MQ helps: Boost NAD⁺ levels Shrink visceral fat tissue Improve insulin sensitivity and cholesterol Preserve muscle mass during weight loss Enhance endurance Activate longevity pathways And it does it by blocking an enzyme that works against you—NNMT. This isn't magic—it's smart metabolic science. And it might just be the edge you need if you're hitting a plateau or looking to optimize how your body performs, heals, and ages. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!  

It's only June. That means you still have six full months to change your life. Seriously. Who do you want to be when the ball drops on December 31st?Are you going to be crying in the bathroom again because nothing fits? Googling “how to lose weight fast” for the hundredth time? Or are you going to feel proud as hell that you didn't give up on yourself this time?In this episode, I'm talking about what's actually possible in six months and how showing up with consistency (not perfection!) can transform how you feel, how you live, and how you see yourself.If you're tired of starting over every Monday, hating your life, emotionally eating your days away, and waiting for “the right time,” this is your wake-up call.Let's talk about who you could be by the end of the year and how to start becoming her now.

Part informative, part a shameless plug for Dr. Seltzers very own product, Apex RX. Find out how adding Essential Amino Acids to your menu can boost results. What are EAA's, what to look for when buying, when to take, and what the benefits are.    APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com      

Today we do a round-up of some of the recent semaglutide trials. Does semaglutide ever miss? But what about tirzepatide, which causes even more weight loss?We also review two new critical care trials, FLUID and the UK-ROX, new platelet transfusion guidelines, and a new retrospective study of apixaban vs rivaroxaban vs warfarin. Oral Semaglutide for Diabetes with Cardiovascular Disease or CKD (SOUL)Semaglutide for Peripheral Artery Disease (STRIDE)Semaglutide for MASH (ESSENCE)Semaglutide vs Tirzepatide for Obesity (SURMOUNT-5)Normal Saline vs Lactated Ringers (FLUID)Conservative Oxygen Targets in Mechanically Ventilated Patients (UK-ROX)Platelet Transfusion GuidelinesApixaban vs Rivaroxaban vs Warfarin Music from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5WKGKXFW2R

Welcome to the first episode of Diamond Paint and Podcast — a cozy space where I decompress, diamond paint, and talk through the emotional weight of everyday life.This series is for those of us who are just trying to feel like ourselves again one tiny sparkle at a time. No filters, no scripts, no pressure. Just real talk while I work on something that feeds my soul.In this first episode, I'm catching you up on life lately, how I've been feeling, and where my head's been. It's not polished. It's not planned. It's just me decompressing, rambling, and trying to process the chaos with a side of bling!

Listen in as Joseph Kim, MD, MPH, MBA, interviews Natalie, Orbach, PA-C, to learn about how she implemented patient-centered and individualized treatment plans to improve obesity care at her practice, includingDiscussing weight and how nutrition, physical activity, mental health, and pharmacotherapy strategies can helpMeeting patients where they are at and offering slow, incremental changes that support long-term outcomesReferring patients to community resources and other professionals as needSharing lessons learned for those interested in implementing similar strategies in their practice PresenterJoseph Kim, MD, MPH, MBAPresidentQ Synthesis, LLCNewtown, PennsylvaniaNatalie Orbach, PA-CPhysician AssistantFeirtag & Ramos, PALutherville, Maryland Link to full program: https://bit.ly/45P0v8z

Welcome to The Peptide Podcast. Today we're going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You're eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You're not doing anything different. You're still taking the meds. Still trying to eat well. Maybe you're walking more or lifting weights. But suddenly, nothing's happening—and the frustration kicks in. Sound familiar? Let's talk about what's really going on. 1. What Causes the Plateau? First of all, if you're in this place right now: you didn't mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn't just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It's a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal.  2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let's talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you're on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It's non-negotiable. Here's why. When you're losing weight—whether it's from a medication like semaglutide or just eating in a calorie deficit—your body isn't just pulling energy from fat. If you're not careful, it's also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you're doing absolutely nothing. So if you're not actively sending a signal to your body to keep that muscle, it'll start to let it go. That's where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you're telling your body: “Hey, I need this muscle. Don't burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you've hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don't have to become a gym rat. You don't have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn't about just losing weight—it's about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let's get into the mental side of this journey—because it's just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I'll be honest: weighing yourself every single day is not ideal. Here's why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you're slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a pasta dinner or even a healthy grain bowl can cause a temporary increase on the scale. Digestive contents – Let's be real: if you haven't had a bowel movement (constipation) or just ate a bigger meal, the scale might reflect that. Doesn't mean you gained fat. Inflammation or illness – If you're recovering from an illness, injury, or even a hard workout, your body retains extra water as part of the healing process. Again—temporary. But here's what happens when we don't understand this, we step on the scale, see a higher number, and panic. We question everything—“Am I doing something wrong? Is the medication not working? Should I eat less?” And that mindset spiral can lead to unnecessary stress, restriction, or even giving up. So what should you do instead? Focus on trends over time, not daily weigh-ins. Weigh yourself once a week at most, ideally at the same time of day, under the same conditions (like first thing in the morning before food or water). Or better yet—track non-scale victories: clothes fitting better, improved energy, reduced cravings, less inflammation, better digestion, even clearer skin. These are all signs your body is healing and progressing. Remember, your worth is not defined by a number, and fat loss is not always linear. There are ups, downs, pauses, and breakthroughs—and all of them are part of the process. 4. Habits: Recheck Your Routine Now, here's where we get really honest. Because as the months go by, it's normal for habits to loosen up. Maybe you're not tracking portions quite as closely. Maybe your steps have dropped. Maybe “just a bite” here and there has crept in more often than you realize. This doesn't make you bad or lazy—it makes you human. But if progress has stalled, it's worth revisiting the basics: Are you eating mostly whole, minimally processed foods? Are you staying hydrated and watching added sugars? Are you eating out frequently without paying attention to portions? Are you still moving your body every day? Small shifts can make a big difference. 5. Food Noise: Why It's Sneaking Back One of the most exciting things about GLP-1s is how much they reduce food noise—that constant mental chatter about snacks, cravings, and what's in the fridge. But for many people, that quiet doesn't last forever. Over time, especially as your body adapts to the medication or your dose levels off, food noise can return. You might find yourself thinking about food more often or wanting things you weren't craving before. This doesn't mean the med has stopped working. It means your biology is adjusting. What helps: Keeping meals protein-forward and fiber-rich Eating at regular times to avoid dips in energy or blood sugar Identifying emotional vs. physical hunger Managing stress and sleep, which both drive cravings This is the time to build real strategies—so you're not relying on the med alone. 6. Emotional Eating This brings me to my next point. Let's talk about something that often flies under the radar but can make a huge difference in your weight loss journey—emotional eating. This is when feelings like stress, boredom, anxiety, or sadness trigger you to eat, even if you're not physically hungry. It's totally normal, and many people experience this at some point. Now, GLP-1 medications like semaglutide or tirzepatide do a great job at reducing physical hunger by influencing hormones that control appetite. But they don't always fully address the emotional side of eating. So, even if your stomach feels satisfied, those emotional triggers can still push you toward cravings or eating for comfort. Recognizing emotional eating is the first step. Try to notice when you're eating because of feelings rather than hunger. Strategies like mindful eating, journaling your emotions, or finding alternative outlets—like walking, meditation, or chatting with a friend—can really help. If emotional eating is a big hurdle, working with a therapist or counselor who specializes in behavioral health can provide tools to manage those feelings without turning to food. Remember, managing emotional eating alongside your GLP-1 treatment can make a huge difference in overcoming plateaus and reaching your goals more sustainably. 7. Set Realistic Expectations: Fat Loss Isn't Linear Lastly, I want to talk about setting realistic expectations. I can't stress the following enough. You are not supposed to lose weight every single week forever. Your body needs breaks. Your metabolism needs to reset. And your mind needs time to adapt to this new version of you. Think of your fat loss journey like a staircase—not a slide. There are flat spots before the next drop. And guess what? Some of the most important changes—like maintaining your weight, building strength, or stabilizing your habits—happen during those flat spots. You don't need to push harder or go more extreme. You just need to keep showing up consistently. My Final Thoughts: Trust the Process The bottom line is trust the process. If you're on a GLP-1 and the scale has stalled, take a deep breath. This is a normal part of the process. It's not the end—it's just a signal to pivot and refocus. We want to build muscle. Prioritize protein. Revisit your habits. Stay active. And most importantly, don't give up. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

Since Dr. Tiffany McCormack began her practice with just a few employees, she's grown into a full team offering everything from lasers and injectables to vaginal rejuvenation in a 12,000-square-foot facility featuring a surgery center and a medical spa.Scaling up is not without growing pains. From a close-knit team of 2 or 3 to a staff of 30, building the right company culture is the key to success. Opening up about navigating the competitive world of aesthetics, her focus on quality care and strong community connections makes her practice stand out. As co-chair of Hot Topics for The Aesthetic Society, Dr. McCormack gives us a peek into what's trending right now, from the wellness boom in aesthetics and skin-rejuvenating exosomes to next-gen breast implants like Motiva and cutting-edge procedures like rib remodeling.About Dr. Tiffany McCormackAs the proud mother of two young children, Dr. Tiffany McCormack knows what a gift it is to become a mom. As a distinguished plastic surgeon, she knows the physical rigors that the body goes through during pregnancy and how to reverse their effects. She has helped many patients in the Reno, Nevada and Lake Tahoe, California areas to enjoy the best of both worlds—the joy of having children and the confidence that comes from looking and feeling your best.Learn more about Reno plastic surgeon Dr. Tiffany MCormackFollow Dr. McCormack on Instagram @drtiffanymccormackGuestTiffany McCormack, MDReno Tahoe Plastic SurgeryHostRobin Ntoh, VP of AestheticsNextechPresented by Nextech, Aesthetically Speaking delves into the world of aesthetic practices, where art meets science, and innovation transforms beauty.With our team of experts we bring you unparalleled insights gained from years of collaborating with thousands of practices ranging from plastic surgery and dermatology to medical spas. Whether you're a seasoned professional or a budding entrepreneur, this podcast is tailored for you.Each episode is a deep dive into the trends, challenges, and triumphs that shape the aesthetic landscape. We'll explore the latest advancements in technology, share success stories, and provide invaluable perspectives that empower you to make informed decisions.Expect candid conversations with industry leaders, trailblazers and visionaries who are redefining the standards of excellence. From innovative treatments to business strategies, we cover it all.Our mission is to be your go-to resource for staying ahead in this ever-evolving field. So if you're passionate about aesthetics, eager to stay ahead of the curve and determined to elevate your practice, subscribe to the Aesthetically Speaking podcast.Let's embark on this transformative journey together where beauty meets business.About NextechIndustry-leading software for dermatology, medical spas, ophthalmology, orthopedics, and plastic surgery at https://www.nextech.com/ Follow Nextech on Instagram @nextechglow

How do weight loss injections work and does the weight pile on again when you stop them? You’ve heard about your G-spot but what about your A-spot and your O-spot ? And how to deal with a phobia of needles. In this episode, Bariatrician GP Dr Jessica McEwan talks about the potential benefits and risks of GLP-1 agonists including what happens if you take too much. We also discuss how to talk to your GP to find out if you meet the appropriate guidelines for prescription and how lifestyle changes including diet and exercise are crucial to their success. Also, we talk about how the food industry is trying to make ultra-processed foods even more addictive to override the effects of these drugs. Ask The Doc: Ask us a question in The Waiting Room. Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can email well@mamamia.com.au, send it anonymously here, email here or leave us a voice note here. THE END BITS Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriberCREDITS Hosts: Claire Murphy and Dr Mariam Guest: Dr Jessica McEwan Senior Producers: Claire Murphy and Sasha Tannock Audio Producer: Scott Stronach Video Producer: Julian Rosario Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

In this quick hits episode, you are going to hear a clip from my most downloaded episode to date! I take a deep dive into the world of GLP-1s, the revolutionary weight loss medications that have captivated the health and wellness scene. We all know that whenever there's a new breakthrough, doubts and controversies tend to emerge, leaving us wondering if it's too good to be true. But fear not! In this show, I am here to unravel the mysteries and shed light on these drugs like never before. My goal is to address your concerns, provide clarity, and empower you with the knowledge to make informed decisions. I will share my own journey on tirzepatide plus client experiences. Whether you're considering these medications or simply seeking accurate information, this episode will be your ultimate resource. So sit back, relax, and join me on this captivating journey into the realm of GLP-1s. By the end of this podcast, you'll have a comprehensive understanding of the pros and cons, equipping you with the insights to navigate this topic with confidence. It's time to separate the facts from the myths and arm yourself with the information you need. Listen to the full episode here.   Sponsors Get $100 off your CAROL bike with coupon code HORMONE here.     Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada.   Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs  Peptide Therapy for weight loss    Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here.   Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY!   To our nursing audience members, our podcasts qualify for nursing CE @ RNegade.pro. Provide # CEP17654.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

You ever lie in bed at night, thinking about all the things you're going to do tomorrow, like wake up early, eat better, clean the house, work out, be more present, but then tomorrow comes… and you're right back in survival mode? Girl, I get it! Please hear this: you're not lazy - you're at maximum capacity. In this episode, I'm getting real about the exhaustion of good intentions that never get met, the emotional weight of feeling stuck, and the shame that sneaks in when you know you're capable of more but can't seem to show up. If you're just getting by and tired of feeling like you're failing… this one's for you.

*The sound is messed up a few times because of my husband's Morse Code. He said he is sorry. On this episode, Mookie G and I conduct a live experiment as we see what happens when you are on weight loss medication (Wegovy, Tirzepatide, Ozempic, Mounjaro) and you drink booze. We chat about how we are feeling and our results on the drugs so far. Also, my Comedy Special "Indoor Wife" is OUT NOW on my YouTube Channel Amy Brown Comedy. * PS- We are NOT doctors. Duh. So don't think we know anything about anything. Out Now! My new standup special "Indoor Wife" on YouTube at Amy Brown Comedy: https://youtu.be/q0eZEVW1Wfk?si=548z1A1UxVH_31aLMookie G and the Whistle Clip! https://youtu.be/xK_uduPyLfM?si=_3P3uoaFAcD_PVrl00:00:00 -My New Special Is Out!00:02:40 - Moochie G and I take our shirts off00:03:10 Greg's Garage Show00:07:30 Gin And Tonics00:14:19 How the weight lose drugs work. 00:18:36 Amy's Mayonnaise Problem 00:22:54 Pretending to like spicey food to catch a man. 00:23:41 Getting Old stomach00:24:53 Where is the diarrhea coming from?00:32:59 Heart too sick to fly to Vegas00:35:40 Mookie uses his racism whistle! 00:36:34 Colonoscopy Corner00:40:49 Public Service Announcement about Bidets 00:50:48 HRT for perimenopause and Testosterone for Men00:55:25 Save the Butts Meghan Trainor and Lainey Wilson00:57:44 EMS training for muscles 01:01:07 Eating for emotional reasons 01:14:53 Mookie's Weight Goal Reveal01:18:22 Injection LocationsSign up to get an email when I come to your area. I promise not to spam you! https://tr.ee/amybrowncomedyemailsAmy Brown Comedy Podcast is a weekly giggle-fest with, me, Amy Brown. Only silly stuff here while I try to navigate perimenopause and the comedy world at the same time. Yikes! New episode drops every Monday-ish. Full Video on Youtube and Spotify. https://amybrowncomedy.com/podcastRainbow Trucker Hats and Indoor Wife T shirts here:https://amybrowncomedyshop.square.site/For more nerdy comedy subscribe and like my YouTube Page.https://www.youtube.com/@amybrowncomedyMy shows are here…https://linktr.ee/AmyBrownComedyhttps://www.facebook.com/amybrowncomedy/https://www.instagram.com/amybrowncomedyAmy Brown's silly smart ​standup reflects on motherhood, married-hood, dyslexia, and the perils of shorty shorts. ​Her debut special “Indoor Wife” is out now on her Youtube (Amy Brown Comedy) where you can also find her weekly podcast, Amy Brown Comedy Podcast. Accolades include​ touring around the country as a headliner for Moms Unhinged, opening for Real Housewife of New York, Sonja Morgan in Sonja In Your City, Joe Dombroski, Katherine Blanford, April Macie, Emmy Blotnick, Liza Treyger, Ali Macofsky & Adrienne Iapalucci. She is a regular at Atlanta's Laughing Skull Lounge and was in the top 101 in The World Series of Comedy 2022/2023 in Las Vegas. She was a finalist in the Funniest Person in Rochester 2022 and has performed in The Rochester Fringe Festival, The Boulder Comedy Festival, Oak City Comedy Festival, The North Carolina Comedy Festival, and West End Comedy Fest. She also hosts a weekly podcast and Youtube series called Amy Brown Comedy Podcast. Find her at www.amybrowncomedy.com.Producer Joel Ruiz, Do You Validate https://www.instagram.com/do_you_validate/https://www.doyouvalidate.com/

Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go!Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07).The Good Stuff:Trial Files, a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:08 - 7:53)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Can you actually be healthy at any weight? What do leeches have to do with gynaecological issues? And what to do if you keep getting styes in your eye. In this episode, we have an important conversation about weight. Endocrinologist Dr Isobelle Smith talks about whether weight loss is more than just calories in and calories out, how to downsize fat not muscle and what your hormones have to do with your weight. We also discuss whether BMI is still a valid measure and how focusing on your health, rather than your weight may be the key. Also, is a “weight set point” actually a thing? Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can email well@mamamia.com.au, send it anonymously here, email here or leave us a voice note here. Ask The Doc: Ask us a question in The Waiting Room. THE END BITS Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriber CREDITS Hosts: Claire Murphy and Dr Mariam Guest: Dr Isobelle Smith Senior Producers: Claire Murphy and Sasha Tannock Audio Producer: Scott Stronach Video Producer: Julian Rosario Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

In this Healthed lecture, A/Prof Samantha Hocking provides an update on this latest study and what it means for prescribing clinicians who are using these agents as part of their management of patients with obesity.See omnystudio.com/listener for privacy information.

In this episode of The Perfect Dose, Dr. Kristen Herzog breaks down the causes behind “Ozempic Face” the hollowing, skin laxity, and accelerated aging that can happen during rapid weight loss from GLP-1 medications like semaglutide (Ozempic, Tirzepatide). She explains why these changes occur, how to prevent them with collagen-boosting treatments like Sculptra and Morpheus8, and when to consider dermal fillers. Whether you're currently on a GLP-1 or planning to start, this episode lays out a proactive skincare protocol to protect your face while hitting your weight loss goals.Timestamps00:00 Intro01:46 Why Does Ozempic Face Happen?03:05 Don't Lose Weight TOO Fast04:34 Time for Sculptra05:21 RF Microneedling for Skin Tightening06:00 Correcting AFTER Weight Loss07:00 Using Fillers 08:01 RecapDon't forget to follow Dr. Herzog on Instagram @the_perfectdose for more skincare tips!--------------

In this episode of the Irresistible You podcast, we're talking about the importance of finding your soul snack—something that feeds your soul so you're not constantly turning to food for comfort. Since Chuy passed away, my nights have felt painfully quiet. He was my constant companion during the late-night hours when the house finally settled. That kind of loss leaves a void, but here's the thing… I didn't slip back into emotional eating, and that's because I already had the Irresistible You framework to guide me.One of the most powerful tools in that framework? Feed Your Soul.Lately, diamond painting has been helping me fill that space with peace instead of food. Let's talk about why you need a soul snack and how to find one that works for you.If you've ever reached for food when what you really needed was something deeper, this episode is for you.

This week, Kate, Mark, Gary and Henry discuss 4 great new POEMs: foot care wipes for patients at risk of diabetic foot infection, resuming DOACS following intracerebral hemorrhage in adults with a fib, treating prediabetes with tirzepatide, and more on intermittent fasting.Show linksBMJ Magic Evidence interactive review of diabetes medications. A great practice and teaching tool: https://matchit.magicevidence.org/230125dist-diabetes/#!/https://www.ncbi.nlm.nih.gov/pubmed/31574019https://pubmed.ncbi.nlm.nih.gov/39964684/ https://pubmed.ncbi.nlm.nih.gov/40023176/ttps://pubmed.ncbi.nlm.nih.gov/39536238/https://pubmed.ncbi.nlm.nih.gov/40163873/

You've heard all the buzz around tirzepatide—and maybe you're even taking it—but you're not seeing the results you hoped for. You're not alone. In this eye-opening episode, Dr. Jen White breaks down the real reasons why this powerful peptide may not be delivering its full potential yet—and exactly what you can do about it. From insulin resistance and inflammation to increased energy and vitality, tirzepatide, has the potential to transform your health. But it's not a quick fix, and Dr. Jen shares the foundational pieces that must be in place to unlock its magic.  Whether you're just getting started or have been cycling this peptide for a while, this episode will help you reframe, refocus, and take empowered action in your health journey. Themes:  Why tirzepatide is not new—and why that's actually a good thing The true benefits: improved blood sugar, lower inflammation, metabolic reset How to optimize your dosing with intuition and personalization Why your body needs a solid health foundation first (think: sleep, nutrition, movement) The role of patience—results can take weeks or even months How cycling on and off tirzepatide can improve long-term outcomes The power of advocating for yourself in treatment and dosing Why tirzepatide could be a miracle solution—but only with a holistic approach   Connect with Jen: 

Ever wondered how people make dramatic body transformations that actually last? In this raw and honest episode, Dave Kennedy opens up about his five-year journey from 320 pounds to the best shape of his life at age 42."How do you do it?" Dave reveals it's not about quick fixes or miracle diets, but rather a "system of disciplines, a system of regiments, a system of consistency" built gradually over time. Both hosts break down the common misconceptions around fitness transformations, explaining why dramatic overnight changes rarely stick. Instead, they advocate for building small, sustainable habits that eventually become lifestyle changes.The conversation tackles the hierarchy of importance in fitness: why food management trumps exercise when starting out, how to separate the roles of calorie management, cardio, and resistance training, and the vital importance of patience. Dave shares candid insights about formerly weighing 320 pounds and how tracking calories fundamentally changed his relationship with food, while Ben offers practical frameworks for approaching fitness as a long-term journey rather than a quick sprint.They don't shy away from discussing controversial topics like GLP-1 agonists (Semaglutide, Tirzepatide), acknowledging their benefits while emphasizing they're not substitutes for building proper habits. Perhaps most powerfully, they explore how community support creates accountability and knowledge-sharing that dramatically increases success rates.Whether you're just starting your fitness journey or trying to break through a plateau, this episode delivers actionable wisdom from two people who've both lived the transformation process. Subscribe, share with someone who needs to hear this message, and join us in building sustainable systems that change lives.Support the showCheck out Overclock and Protein Protocol hereWant to know more about coaching? Book a call with Ben here Where to find usWe Hack Health: TwitterWe Hack Health: InstagramWe Hack Health: Discord

This week's topics include USPSTF on screening for syphilis in pregnancy, when to take blood pressure medicines, comparing weight loss drugs, and a narrative intervention for PTSD after an ICU stay.Program notes:0:40 NEJM publication of comparison of obesity medications1:40 Tirzepatide versus semaglutide for 72 weeks2:41 Also had reduction in blood pressure3:26 Rise in congenital syphilis and screening4:26 Disparities among various groups5:26 Highest incidence in the last 30 years6:26 In 2023 210,000 cases of syphilis7:00 When to take blood pressure meds8:00 Monitored blood pressure in a subset8:40 Intervention for PTSD after ICU stay9:40 Self reported PTSD symptoms​​10:40 Must learn to deliver intervention11:40 Physician needed to spend 45 minutes per visit12:42 End

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

I've been waiting a long time to release this one. Dr. Tyna Moore is someone I've wanted to bring on the show because her take on GLP-1s like Ozempic, Wegovy, and Tirzepatide is so refreshingly honest and grounded in both science and clinical experience. There's so much confusion, fear, and flat-out propaganda around these peptides, and today, we clear the air. We talk about how GLP-1 agonists work not just as weight-loss drugs but as powerful regenerative and neuroprotective tools. Yes, they help you stop obsessively thinking about food. Yes, they can dramatically help with insulin resistance. But the real story? These peptides might help heal your metabolism for good. Tyna doesn't hold back. We unpack the massive industry bias against these drugs, the obesity stigma nobody wants to talk about, and the misinformation that's keeping people sick, scared, and stuck. If you've ever wondered whether peptides are a shortcut or a real solution, this episode lays it all out. And if you're using these tools without lifting weights, optimizing sleep, eating real food, and managing your circadian rhythm? You're setting yourself up for muscle loss and disappointment. GLP-1s are not a miracle. They're a tool. But if you use them the right way, they just might change your life.   "I think there's magic in time under treatment with this peptide. I think the longer somebody's on it, the more long-term healing and regenerative benefits we ultimately get." ~ Dr. Tyna Moore   In This Episode: - GLP-1s explained: Ozempic, Wegovy, Mounjaro  - Benefits beyond weight loss: cardiovascular, neurological, regenerative - Why the pushback against Ozempic? - Muscle loss myths - Addressing other common myths and side effects - The emotional side of weight loss - The metabolic dysfunction epidemic and why it starts early - Proper GLP-1 dosing strategies: "low and slow" approach - Dr. Tyna's free resources and education courses For more, visit https://myersdetox.com    Heavy Metals Quiz: Find out your toxicity score and receive a free video series on detoxification at https://heavymetalsquiz.com    Resources Mentioned: Puori PW1 Protein Powder: Get 20% off with code WENDY at https://puori.com/wendy  Tru Energy Skincare: Get a special deal at https://trytruenergy.com/wendy  Organifi Collagen: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox  Fresh Pressed Olive Oil: Get a $39 bottle for just $1 to cover shipping at https://getfreshwendy.com    About Dr. Tyna Moore: Dr. Tyna Moore is an expert in holistic regenerative medicine and resilient metabolic health with nearly 30 years in the medical field. As both a licensed naturopathic physician and chiropractor, she brings a comprehensive perspective to metabolic health, drawing from traditional and alternative medicine. Dr. Moore has made waves with her open-minded exploration of peptides like semaglutide (Ozempic) as tools for healing and longevity. She champions medical autonomy and individual accountability while hosting The Dr. Tyna Show podcast and speaking internationally. Learn more at: https://drtyna.com    Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Join JACC Editor in Chief Harlan Krumholz, MD, SM, as he speaks about this ACC.25 presentation published in JACC. This fascinating study by Rohan Khera et al independently analyzed patient-level data from the SURMOUNT trials of tirzepatide for obesity. The study revealed striking individual variability in weight loss and metabolic response, even to a highly effective therapy—an insight powerfully illustrated through waterfall plots. Reviewers praised the transparent, sponsor-independent approach and the study's contribution to precision medicine, though they noted it was descriptive rather than predictive, underscoring the need for future research to identify what drives differential treatment response.

Study Link: http://biorxiv.org/content/10.1101/2025.04.17.649402v1.full.pdfGet My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Tirzepatide is more effective for weight loss than semaglutide.Cost-effectiveness is crucial in prescribing weight loss medications.Patients with severe obesity should receive more expensive medications for better outcomes.Both medications show significant benefits for obesity-related conditions.Long-term studies indicate sustained weight loss with both drugs.Gender differences affect weight loss outcomes with these medications.Safety profiles show tirzepatide may be better tolerated than semaglutide.The need for affordable drug pricing is emphasized.Clinical benefits extend beyond weight loss to include metabolic health.Future studies are needed to confirm cardiovascular benefits of tirzepatide.Click here to see the studyClick here to join Dr. Spencer's new online clinic

CBS News MoneyWatch correspondent Kelly O'Grady breaks down what to know about the potential financial impact to American consumers after the U.S. and China agreed to temporarily ease tariffs. Music superstar Taylor Swift has been subpoenaed in the ongoing legal dispute between Blake Lively and Justin Baldoni over allegations surrounding the making of their 2024 film "It Ends with Us."  A new study from the New England Journal of Medicine compares two weight loss drugs, Tirzepatide and Semaglutide. CBS News medical contributor Dr. Celine Gounder breaks down the findings. Nicole Scherzinger is making her Broadway debut in the stripped down, modern revival of "Sunset Blvd." She talks with "CBS Mornings" about the show, taking on the role and her first Tony nomination. In an exclusive "Begnaud's America" interview, CBS News contributor David Begnaud speaks with Gus Waltz, the son of Minnesota Gov. Tim Walz, who stole the spotlight during the 2024 Democratic National Convention. He's opening up about that moment and a learning disorder that is often misunderstood. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Os medicamentos injetáveis para emagrecimento, conhecidos como “canetas emagrecedoras”, incluindo Ozempic, Wegovy, Saxenda, Mounjaro e similares vinham sendo vendidos livremente no Brasil, sem a necessidade de prescrição médica. Mas isso vai mudar.A Agência Nacional de Vigilância Sanitária (Anvisa) aprovou uma nova regra para a venda desses medicamentos, que só poderá ser feita mediante apresentação de receita médica em duas vias, sendo que uma delas ficará retida na farmácia - procedimento semelhante ao já adotado para antibióticos.Neste episódio, conversamos sobre as indicações desses medicamentos, seus efeitos colaterais e a importância do acompanhamento médico para o uso correto.Links relacionados:Tirzepatide as Compared with Semaglutide for the Treatment of ObesityComida Sem Filtro #88 – Injetáveis Para EmagrecerComida Sem Filtro #146 – Ozempic: Como Evitar O Reganho De Peso?Comida Sem Filtro #125 – Efeito Ozempic Na Indústria De AlimentosEstamos no Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dr. Souto⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sari Fontana⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Para ser avisado sobre cada novo episódio e receber os links das matérias mencionadas e as referências bibliográficas por e-mail, cadastre-se gratuitamente em ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drsouto.com.br/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Adquira seu livro - UMA DIETA ALÉM DA MODA: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (também na versão Kindle)"Dance of the Sugar Plum Fairy"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://creativecommons.org/licenses/by/3.0/⁠

Dave discussed the latest update in the OFA vs FDA compound tirzepatide battle, as well as this weeks news in obesity medicine. Find our substack and all promotional links here: https://linktr.ee/manonthemounjaro

腸泌素藥物如 Semaglutide、Tirzepatide 可以絕佳地控制血糖，更有驚人的減重效果，推出後風靡全球，有長達三年的時間被美國 FDA 認定為供不應求。除了糖尿病、減重效果之外，這些腸泌素藥物亦對大量重要疾病有潛在的治療效果（尚待臨床試驗證實），堪稱當代神藥。Tirzepatide 供應商禮來 (Eli Lilly) 因此躍升世界市值最高藥廠，諾和諾德 (Novo Nordisk) 也因 Semaglutide 一度成為歐洲最有價值的公司。 本集節目邀請到新陳代謝科醫師黃峻偉醫師，他同時是專欄《糖尿病筆記》作者。黃醫師與我們介紹糖尿病藥物、腸泌素的歷史延革，講解為什麼腸泌素藥物能有絕佳的減重表現，也討論這些藥物的巨大影響力。  

It seems like we all have patients taking Semaglutide or Tirzepatide and in this episode Tom Viola breaks down the things we need to know. How does it act? What should we be on the look our for? What oral/systemic manifestations might there be? Be sure to give this short episode a listen! Resources: Be sure to reach out to him if you have any questions by emailing TomViola@tomviola.com, visit his website TomViola.com or check out his social media - @pharmacologydeclassified

EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I've got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn't tell the whole truth. There's more going on here, and you deserve the full picture. Topics Covered: Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss? How does it affect metabolic adaptation in people with obesity? Can it boost fat oxidation? Is the “calories in, calories out” model outdated for GLP-1s? What does this mean for long-term metabolic health? Sponsored By: Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Sundays | As a Listener of The Dr Tyna Show, you can Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. Liver Love | Go to https://store.drtyna.com/products/liverlove Use code DRTYNASHOW at checkout to save. LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna BIOptimizers | For an exclusive offer on MassZymes go to Bioptimizers.com/DRTYNA and use promo code DRTYNA On This Episode We Cover:  00:00:00 – Introduction  00:02:44 – Obesity study on GLP1s and weight loss 00:04:21 – Calories in vs. calories out 00:05:44 – Resting metabolic rate 00:09:25 – Metabolic adaptation during dieting 00:12:11 – Tirzepatide dosing in clinical studies 00:15:49 – Maintaining weight loss 00:18:15 – GLP1s &  increased fat oxidation 00:19:14 – GLP1 microdosing myths 00:26:06 – Metabolic rate drops vs. metabolic improvements 00:29:51 – Lessons from the Biggest Loser study 00:34:20 – Study Comparation 00:35:25 – Weight loss, inflammation, and aging 00:36:35 – Health autonomy  00:40:23 – Caloric restriction and the CALERIE study Studies Mentioned:  Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Show Links GLP-1s Done Right University Dr. Tyna's Strength Corner Metabolic Revamp Toolkit + Masterclass Further Listening:  GLP1s Uncovered (Free Class) EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.