Podcasts about tirzepatide

In this episode, I'm talking honestly about weight loss burnout. The mental exhaustion that comes from constantly thinking about food, planning meals, trying to “be good,” starting over, tracking, and feeling like your body is always a project that needs fixing.I also share what this experience has been like for me while being on Tirzepatide. The food noise is quieter, but now I find myself in this strange in-between space where I'm hungry, but nothing sounds good. I take a few bites and feel full… while somehow still feeling hungry at the same time. And honestly? I'm tired.This episode isn't anti-weight loss. It's about what happens when your entire life starts revolving around shrinking yourself, and the realization that maybe peace matters too.Because you deserve a life bigger than calorie counting.Show Notes

Hi, it's Heather and I'm so glad you're here! Welcome to the newly renamed Health, Harmony and Heather podcast! This space is dedicated to exploring social phenomena, the human condition, and how we can better connect with ourselves, each other, and the planet. In this episode, I'm thrilled to welcome back my personal clinician and friend, Lauren Rosenberg. Lauren is a highly experienced physician associate, internal medicine expert, and the founder of Vent Health, a practice dedicated to shifting the medical focus from disease treatment to true preventative care and health optimization. Today, we are stripping away the stigma and diving deep into the raw science, truth, and real solutions for perimenopause, menopause, and post-menopause. The days of women suffering in silence are over. The "One Day" Truth: Why menopause is actually just one single day in your life, and what it means for your timeline. The Hormone Rollercoaster: A breakdown of how estrogen, progesterone, and testosterone behave during your cycle—and what happens when they plummet. Symptoms Beyond Hot Flashes: From brain fog, joint pain, and "frozen shoulder" to anxiety, weight gain, and urinary changes. The WHI Study Debunked: The real story behind the 2002 Women's Health Initiative study that scared a generation away from life-saving hormone replacement therapy (HRT). The Power of Peptides: How cutting-edge tools like GLP-1s, Tirzepatide, Retatrutide, and cellular repair peptides can be paired with HRT for total vitality. At-Home Longevity Habits: The non-negotiable lifestyle habits—including grip strength, Zone 2 training, lifting weights, protein intake, and specific magnesium variations—to help you thrive. Connect with Lauren Rosenberg: Learn more at myventhealth.com or follow her on Instagram @MyVentHealth. Virtual Menopause Care: Check out Midi Health (joinmidi.com) for accessible, insurance-based virtual menopause care. Trusted Supplement Brands: Designs for Health, Pure Encapsulations, Thorne, and Metagenics. AirDoctor.  Head to www.AirDoctorPro.com  and use promo code HEATHER to get $250 off select AirDoctor air purifiers, including the 3500, 4000, and 5500 models. Plus, you'll receive a free 3 year warranty, an $84 value, and AirDoctor's 30-day money back guarantee. This is an exclusive podcast only offer, available now! Don't forget to LIKE this video, SUBSCRIBE to the channel, and hit the notification bell so you never miss an episode. Let's live the last third of our lives with vitality, strength, and harmony! #Menopause #Perimenopause #HormoneReplacementTherapy #HealthyAging #Peptides #Longevity #WomensHealth #HealthHarmonyAndHeather Learn more about your ad choices. Visit megaphone.fm/adchoices

In this solo episode of Mommywood, I'm opening up about my personal experience taking tirzepatide after struggling with postpartum weight, brain fog, exhaustion, and constant “food noise” after having my daughter. I talk about what finally pushed me to try it, how it affected my relationship with food, my confidence, energy levels, and even the way I approach self-tapes as an actor mom.I'm also sharing the questions I wrestled with around body image, motherhood, stigma, and whether it felt like “cheating.” Plus, I answer listener questions about side effects, costs, microdosing, acting, parenting, and what happens after stopping.This episode is not medical advice — it's simply me honestly sharing my own experience navigating wellness, identity, and confidence in motherhood and Hollywood.

Welcome to the latest episode (June 2026) of Diabetes Core Update, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Update: Shah S, et al. "Food Coloring Additives and Incidence of Type 2 Diabetes in the NutriNet-Santé Prospective Cohort Diabetes Care. 2026;49(6):1067–1077. doi.org/10.2337/dc25-2727 Hespanhol L, et al. "Automated Insulin Delivery Systems in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis." Diabetes Care. 2026;49(6):1134–1143. doi.org/10.2337/dc25-2435 Tatum K, et al. "Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer." JAMA. Published Online: May 11, 2026 2026;9;(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133 Winkler C, et al. "Screening Children for Early-Stage Type 1 Diabetes." JAMA. Published Online: May 21, 2026 doi:10.1001/jama.2026.6085 Würtz Yazdanfard P, Kosjerina V, Wood-Kurland H et al. "Effectiveness and Safety of Semaglutide in Type 1 Diabetes: A Danish Nationwide Cohort Study (2018–2024)" Lancet. Volume 66, 101716, July 2026. doi:10.1016/j.lanepe.2026.101716 Horn D, Aronne L, Wharton S et al. "Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial." Lancet. Published online May 12, 2026. doi:10.1016/S0140-6736(26)00656-2 Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, click here.

Taylor and I are back for another Reader Mailbag. This one covers a lot of ground.We start with anhedonia on GLP-1s because the questions on this have been nonstop. People are experiencing it on Semaglutide, Tirzepatide, and Retatrutide and we break down why it happens, whether it is dose related, and what you can actually do about it.From there we get into the Reta and heart rate debate, Taylor's GLP rotation strategy, and whether the cardiovascular tradeoffs are actually worth worrying about.Then Taylor takes over for the hormone optimization section for young women in their twenties and thirties. Her personal story on this one is worth watching alone.We also cover accidental peptide overdoses, what to do when it happens, and finish with teen acne solutions using peptides and topicals.Submit your questions for the next episode at the link below.For research and entertainment purposes only.Links, cheatsheet, private group and more

In this episode, we break down the science behind GLP-1 medications including Ozempic, Wegovy, Zepbound, Mounjaro, semaglutide, and tirzepatide. Learn how GLP-1 weight loss medications work, their role in appetite suppression, insulin regulation, metabolic health, obesity treatment, and type 2 diabetes management.This evidence-based discussion explores GLP-1 benefits, side effects, muscle loss concerns, weight regain after stopping medication, nutrition considerations, digestion, metabolic adaptation, and sustainable wellness strategies. If you're considering GLP-1 medications or simply want a smarter conversation about obesity medicine, weight loss, longevity, and metabolic health, this episode delivers a clinically grounded wellness perspective. Disclaimer: This podcast is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. The views shared are intended to support informed wellness conversations and should not replace individualized guidance from your physician or qualified healthcare provider. Always consult your healthcare team before making decisions regarding medications, treatment, nutrition, or health management.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications:1. Orforglipron for maintenance of body weight reduction  - Nature Medicine2026. Discussion by:Guest:Joe Gonella, MD Resident - Abington Family Medicine Residency Program Jefferson Health2. Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN) Lancet 2026.  Discussion by: Guest:Neil Skolnik, MDProfessor of Family and Community MedicineSidney  Kimmel  Medical College Thomas Jefferson UniversityAssociate Director - Family Medicine Residency ProgramJefferson Health – Abington3. Survival and Recurrence with GLP-1 Receptor Agonists in Breast Cancer" – JAMA Network Open Discussion by:Guest:Neil Skolnik, MDProfessor of Family and Community MedicineSidney  Kimmel  Medical College Thomas Jefferson UniversityAssociate Director - Family Medicine Residency ProgramJefferson Health – Abington4. In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia.   NEJM 2026 Discussion by:Guest:Alex Sauer, MD Resident - Abington Family Medicine Residency ProgramJefferson HealthMedical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit  http://naceonline.com to engage in more live and on demand CME/CE content.

All links here: ⁠https://hunterwilliamshealth.com/linksTimestamps:00:00 Intro01:00 Why I'm making this video04:00 The plan: peptides with direct anti-cancer evidence06:02 AOD-9604 and HGH Frag 176-19107:42 BPC-15709:54 DSIP (Delta Sleep Inducing Peptide)11:08 Epitalon12:30 Follistatin 34413:30 GHK-Cu14:36 Kisspeptin15:58 KPV17:18 LL-3718:46 Melanotan 219:58 MOTS-c21:12 Retatrutide22:34 Semaglutide23:40 SS-3124:38 Thymalin25:26 Thymosin Alpha-127:00 Tirzepatide27:30 VIP (Vasoactive Intestinal Peptide)28:06 Bottom line and closing thoughtsDescriptionIf you spend any time in the peptide social media world, you've heard it. "Peptides cause cancer." It's the easiest way to scare someone off something, and a lot of people do it without ever showing you a single study.So I went and pulled the studies. In this video I walk through every peptide on the popular research peptide list that actually has direct anti-cancer evidence in the published literature. Not theory. Not mechanism guesses. Actual studies in cells, animals, and in some cases, humans.You'll see what the research says about BPC-157, GHK-Cu, Epitalon, KPV, LL-37, Thymosin Alpha-1, MOTS-c, semaglutide, tirzepatide, retatrutide, and a handful more. Some of this evidence is strong. Some is preliminary. I'm honest about both.This is not medical advice and I'm not telling you peptides cure cancer. That's not what the data says and that's not what I'm claiming. What I am saying is that the next time someone hits you with a 60 second clip telling you peptides cause cancer, you'll have something more substantial to weigh it against.All study links below.

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps: 0:00 – intro  1:32 – Mike Israetel on Retatrutide as the next “miracle drug”  4:06 – concerns with increasing glucagon: thyroid, fat metabolism, reproductive hormones  7:22 – Retatrutide leads to more aggressive weight loss at the expense of health  10:17 – is Retatrutide really healthier for your internal organs (fatty liver, heart, kidney)  11:41 – healthy weight loss does NOT have to be uncomfortable  14:44 – Retatrutide signaling explained: what are the long-term effects?  20:46 – extreme dieting feels terrible for a reason; restriction is not the solution  24:10 –Mike Israetel's diet explains his view of Retatrutide  27:50 – Kinobody (Greg O'Gallagher) says using GLP-1 medications is “high IQ"  31:29 – are GLP-1s just a “modern day tool” without consequences?  33:22 – is constant food availability the reason for widespread weight gain and obesity?  40:24 – why Greg Gallagher is getting push-back for taking Tirzepatide  43:09 – does “food noise” justify GLP-1s?45:20 – many fitness influencers have body image issues and perpetuate the cycle  50:40 – the truth about being lean/ripped – what's actually healthy?  57:57 – obsession with body composition as a sign of poor health  1:02:03 – success story: from low-carb fear to feeling better with carbs  1:04:40 – why people are afraid to try carbs again after low-carb and common mistakes people make when reintroducing carbs   

Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) PT-141 / Bremelanotide [https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html) GHK-Cu copper peptide https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) Tretinoin / Retin-A https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html) NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/) Nicotinamide Riboside / NR https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/) Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/) GLP-1 drugs https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Tirzepatide https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html) BPC-157 https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/) TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/) Tesamorelin https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)   Thymosin Alpha-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/) SS-31 / Elamipretide https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/) Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html) Psyllium husk https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mindy talks about Crab Boils. And then she answers questions about numb tongue, why do men age so well, tennis elbow, Adderall, side effects of Semaglutide, how many grams of fiber do you need, NAD formulations, allergy headaches, blurred vision with Tirzepatide, lump on a toddler's chin, ice cold feet, another Adderall question, grey hair, tally-whackers and loud tummy noises. https://www.youtube.com/@TheDrMindyExperiment See omnystudio.com/listener for privacy information.

All links here: https://hunterwilliamshealth.com/links00:00 — Intro and why I'm doing these masterclasses02:42 — What we're covering and the regulatory timeline04:04 — The two users: weight loss vs longevity05:30 — What Retatrutide actually does (the three receptors)06:50 — Why the glucagon receptor makes Retatrutide different07:54 — Weight loss trial data (1mg to 12mg)10:50 — The longevity data: liver fat, ApoB, blood pressure13:14 — Who the lean biohacker user is13:50 — The titration playbook15:32 — Once weekly vs split dosing19:50 — Morning vs night injections21:02 — How far to push the dose (why 8mg is the ceiling)22:50 — How long to stay on and the regain problem25:44 — Longevity maintenance protocol26:34 — Lean user protocol27:24 — Protein and training are non-negotiable29:06 — Side effects and how to manage them30:20 — The heart rate question and why I use taurine32:00 — The weird skin sensitivity issue33:48 — Pairing Retatrutide with testosterone35:56 — Drug interactions (blood pressure, thyroid, insulin)37:02 — Metrics that matter38:42 — How to cycle off correctly39:54 — The most common mistakes40:42 — How to start, what to do if you plateau43:04 — Should you switch from Tirzepatide?45:28 — Combining Retatrutide with other peptides46:50 — The Ten Commandments of Retatrutide use47:50 — The bottom lineToday's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.Let me know what you think. I plan on doing many more of these on every peptide that matters.⚠️ For research and entertainment purposes only. ⚠️

In this weekly roundup of news coverage, Nick breaks down important stories you might have missed that we should all have eyes on.   Retatrutide Explained: Is It Better Than Ozempic & Mounjaro? A Date Now Costs $200, AI is   Retatrutide is being called the next Ozempic — but is it actually better than Mounjaro and Tirzepatide? Dr. Jeff Gross explains how it works, fat loss results, and what people should know before using it.   Dating Now Costs $200 a Date—Here's Why Gen Z Is Giving Up   Dating now costs nearly $200 per night, and Gen Z is quitting the dating scene. Here's how inflation, dating apps, and 'dateflation' are destroying modern relationships.   Source: https://fortune.com/2026/05/05/is-dating-worth-it-anymore-average-cost-of-dating-nears-200-dollars/    AI Is Making Your Electric Bill EXPLODE (Here's Proof)   AI data centers are draining the power grid and raising electricity prices nationwide. Here's why your bill is exploding — and what we can do about it.   Source: https://chicago.suntimes.com/consumer-affairs/2026/05/13/comed-electric-customer-bills-rising-ai-data-centers-pjm-energy-costs    Our Mission Eyes Wide Open is a space for honest communication. Our goal is to remove the stigmas around mental health, holistic lifestyles, culture, and free speech so you can show up as your authentic self with your eyes wide open. By having real conversations about difficult truths, we move toward collective healing.   Timestamps 00:00 - Introduction to the Eyes Wide Open weekly round-up 01:07 - Retatrutide Explained: Is It Better Than Ozempic & Mounjaro? 13:45 - Dating Now Costs $200 a Date—Here's Why Gen Z Is Giving Up 25:38 - AI Is Making Your Electric Bill EXPLODE (Here's Proof) Find Nick Thompson here:   Nick Instagram: https://www.instagram.com/nthompson513/   UCAN Instagram: https://www.instagram.com/the_ucan_foundation/     YouTube: https://www.youtube.com/@EyesWideOpenContent      LinkedIn: https://www.linkedin.com/in/nickthompson13/       UCAN Foundation: https://theucanfoundation.org/ 

Are GLP-1 medications like Semaglutide, Tirzepatide, and Retatrutide helping or hurting your recovery? In this episode I cut through the hype and fear to talk about the real dangers people aren't discussing, how these medications should actually be used, and why no tool can replace healing your relationship with food. If you're considering a GLP or already using one, this is an important conversation you need to hear.Grab your copy of my FREE 9 page Beginner's Guide to Food Sobriety https://www.foodfreedomwithmary.com/foodsobrietyguideFood Freedom Online Course: https://www.foodfreedomwithmary.com/foodfreedomcourseFood Sobriety Mini Course -https://www.foodfreedomwithmary.com/foodsobrietymcWant to learn more about me and my coaching programs? Do you need private coaching and intensive daily contact with a coach? Fill out my application so we can chat about whether or not my program is for you and which option is best for you. Payment plans available. Don't see a payment option that works for your pay schedule? Let's chat about a custom pay plan.www.foodfreedomwithmary.com/chooseyourpath Join my online community The Food Freedom Tribe! An online community of support, eduction, inspiration, accountability….. Learn more here: https://www.foodfreedomwithmary.com/tribemembership Application: https://docs.google.com/forms/d/1upnWHYK0RXfmyRTqlsF_R06z3NA8LZYHIMWFykq7-X4/viewformInstagram: www.instagram.com/coachmaryroberts Facebook: www.Facebook.com/ketomary71 Facebook group: https://www.facebook.com/groups/4915319108493196/?ref=share_group_linkWebsite: www.foodfreedomwithmary.com Join the email list.Email: mary@foodfreedomwithmary.com

Could the "weight-loss shots" everyone is talking about actually be the next big breakthrough in cancer prevention? In this week's episode of the FMI podcast, I'm joined once again by our Chief Medical Officer, Dr. Mark Holthouse. While Dr. H is a world-renowned expert in hormone health and cardiometabolic medicine, today we are diving into a topic that is reshaping the future of longevity: the direct link between obesity-related cancers and GLP-1 medications. We recently learned that colon cancer is now the leading cause of cancer death for men and women under 50. It's a sobering statistic, but there is hope in the evolving science of metabolic medicine. In this episode, we discuss: The "Four Horsemen" of Aging: Why cardiovascular disease, cancer, dementia, and insulin resistance are all driven by the same cellular pathways. GLP-1s Beyond Weight Loss: How medications like Semaglutide and Tirzepatide work at the cellular level to potentially reduce tumor volume and progression. The "New Kid on the Block": A deep dive into Retatrutide, the experimental triple-agonist showing even more dramatic results in preclinical models. Obesity-Related Cancers: Why fatty liver, chronic inflammation, and nutrient-sensing pathways (like mTOR) create a "pro-cancer milieu." The "Foundational Four": Why, despite all the medical breakthroughs, sleep, clean eating, stress management, and exercise remain the ultimate levers for health. Dr. Holthouse also shares his "minimalist" approach to detoxification and why he's more interested in "reining patients in" from expensive gadgets to focus on what actually moves the needle. Whether you are interested in the latest longevity science or simply looking for ways to lower your family's risk of chronic disease, this conversation is packed with "root cause" insights you won't want to miss.

Joanne Alves e Nordman Wall convidam Caroline Millon para discutir a abordagem da Síndrome de Apneia e Hipopneia Obstrutiva do Sono (SAHOS). Referências: Myers, Kathryn A et al. “Does this patient have obstructive sleep apnea?: The Rational Clinical Examination systematic review.” JAMA vol. 310,7 (2013): 731-41. doi:10.1001/jama.2013.276185Gawrys, Breanna et al. “Obstructive Sleep Apnea in Adults: Common Questions and Answers.” American family physician vol. 110,1 (2024): 27-36.Hong, Yanan et al. “The study of the relationship between moderate to severe sleep obstructive apnea and cognitive impairment, anxiety, and depression.” Frontiers in neurology vol. 15 1363005. 10 May. 2024, doi:10.3389/fneur.2024.1363005US Preventive Services Task Force et al. “Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement.” JAMA vol. 328,19 (2022): 1945-1950. doi:10.1001/jama.2022.20304Palombini, Luciana de Oliveira. “Critérios diagnósticos e tratamento dos distúrbios respiratórios do sono: RERA” [Diagnostic criteria and treatment for sleep-disordered breathing: RERA]. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia vol. 36 Suppl 2 (2010): 19-22. doi:10.1590/s1806-37132010001400007Yeghiazarians, Yerem et al. “Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association.” Circulationvol. 144,3 (2021): e56-e67. doi:10.1161/CIR.0000000000000988Duarte, Ricardo Lm et al. “Obstructive Sleep Apnea Screening with a 4-Item Instrument, Named GOAL Questionnaire: Development, Validation and Comparative Study with No-Apnea, STOP-Bang, and NoSAS.” Nature and science of sleep vol. 12 57-67. 23 Jan. 2020, doi:10.2147/NSS.S238255Gottlieb, Daniel J, and Naresh M Punjabi. “Diagnosis and Management of Obstructive Sleep Apnea: A Review.” JAMA vol. 323,14 (2020): 1389-1400. doi:10.1001/jama.2020.3514Malhotra, Atul et al. “Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.” The New England journal of medicine vol. 391,13 (2024): 1193-1205. doi:10.1056/NEJMoa2404881

In this episode, we rank the first 10 healthiest snacks for fat loss from S (supreme) to F-tier.We hope you enjoy this episode and if you'd like to join us in The Online Fitness Business Mentorship, you can grab your seat at https://www.fitnessbusinessmentorship.comThank you!-J & MWATCH this episode on YouTube: https://youtu.be/vDusakRLsasTIMESTAMPS:(00:00) — Intro(00:11) — This is your LAST CHANCE to get into the Mentorship at the lowest price it will EVER be (don't say we haven't warned you)(01:14) — So... Jordan probably has 2 dogs now?(04:05) — Mike's current training and the difference between being driven by the light rather than the darkness(07:24) — Confirmed: social media still sucks(10:13) — Tirzepatide, Retatrutide, and the fear of missing out(14:22) — Ranking the top 20 healthiest snacks for fat loss (S to F tier)(46:37) — Thanks for listening! (this is your LAST CALL to get into the Mentorship before prices increase!)You can find a full transcript of this episode by clicking hereFollow the show on social:YouTube - https://www.youtube.com/@personaltrainerpodcastInstagram - https://www.instagram.com/personaltrainerpodcastTikTok - https://www.tiktok.com/@personaltrainerpodcastJoin our email list & get our FREE '30 Ways To Build A Successful Online Coaching Business' manual: https://bit.ly/30O2l6pCheck out our book 'Eat It!' at https://www.amazon.com/Eat-It/dp/0008543046If you have any questions you'd like to have answered on the show, shoot us an email at info@fitnessbusinessmentorship.comIf you enjoyed the episode, we would sincerely appreciate it if you left a five-star review.----Post-Production by: David Margittai | In Post MediaWebsite: https://www.inpostmedia.comEmail: david@inpostmedia.com© 2026 Michael Vacanti & Jordan Syatt

Could GLP-1 medications be the missing piece in treating inflammatory skin disease? In this episode of Science is Skin, Dr. Ted Lain sits down with Dr. Lindsey Bordone — former Columbia University associate professor of dermatology, now in private practice at Bordone Dermatology in Scottsdale, Arizona — for a deep dive into metabolic disease and the skin. Dr. Bordone was among the first dermatologists to prescribe GLP-1 agonists for her patients, and in this conversation she explains exactly why. From the link between hyperinsulinemia and chronic inflammation to the visible skin signs of insulin resistance — skin tags, acanthosis nigricans, forearm hair loss — she makes the case that dermatologists are uniquely positioned to catch metabolic disease before any other specialty. Dr. Bordone walks through how she uses tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy), and the emerging triple-G drug retatrutide, including her lab protocols, dosing philosophy, how to manage GI side effects, and the surprising interaction between GLP-1s and estrogen therapy. In this episode: Why high BMI reduces biologic efficacy in psoriasis patients How to check fasting insulin (HOMA-IR) and why most physicians aren't doing it Skin signs of insulin resistance: skin tags, forearm hair loss, and neck skin thickening Tirzepatide vs. semaglutide vs. retatrutide — how to choose and when Retatrutide's remarkable 93% fatty liver clearance rate in clinical trials The truth about sarcopenia and muscle loss on GLP-1 medications Dosing protocols, side effect management, and when NOT to escalate quickly Protein intake recommendations during active weight loss Estrogen and GLP-1 synergy — what dermatologists need to know Lab work to run before and during GLP-1 therapy How to build an insurance case for continued medication coverage Resources mentioned: HOMA-IR fasting insulin/glucose testing AAD resources on metabolic dermatology Bordone Dermatology — Scottsdale, Arizona Enjoyed this episode? Share it with a colleague and leave us a five-star review. Subscribe so you never miss an episode of Science is Skin. To watch this and other episodes, be sure to check out our YouTube page DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.

I tried a GLP-1 for 30 days… and what happened genuinely shocked me. In this episode, I'm sharing my completely honest experience trying a GLP-1 as an emotional eating coach, including both the incredible upsides and the concerns that made me rethink the conversation happening online.We're also diving deep into the science behind: • What GLP-1s actually are • The difference between semaglutide and tirzepatide • What peptides are • Why food noise disappears • How GLP-1s slow digestion • Why protein and strength training matter SO much • The truth about hair loss on GLP-1s • Nutrient deficiencies nobody warns women about • Why these medications are NOT a long-term identity replacementThis is not an anti-GLP-1 episode.And it's not blind hype either.It's the honest conversation women deserve to hear.If you've ever wondered: “Would a GLP-1 help me?” or“Why are these medications changing people's lives?”…this episode will give you a balanced, educational, deeply personal perspective.⭐ If this episode helped you, please leave a review and share it to your Instagram stories and tag me so I can repost you!Get Kylie's exact weight loss BlueprintGet Kylie's Free Weight Loss CourseFollow Kylie on InstagramBOMBSHELL BLUEPRINT WEIGHT LOSS FOR EMOTIONAL EATERS

Jordan and Nate finally tackle the buzzword everyone's been throwing around: peptides. From Ozempic and Gila monster spit to copper creams and hairy butt cheeks (yes, really), the guys break down what peptides actually are, why they suddenly went viral, and whether the hype is justified. They cover the basics in plain English with a fun letters-words-sentences analogy, dig into RFK Jr.'s deregulation of compounding pharmacy peptides, and walk through the most popular ones on the market today. BPC-157 for injury repair, GHK-Cu for skin and hair, Semax for cognition, Melanotan for tanning, Tesamorelin, Tirzepatide, MOTS-c, PT-141, and a few that had the guys laughing about where exactly you're supposed to inject them. Along the way, they discuss peptides hiding in your food (eggs, bone broth, sauerkraut, mushrooms), why aspartame is technically a peptide too, and the difference between supporting your body's natural processes versus messing with gene therapy. As always, the message is the same: tools are tools. Don't reach for the magic injection when whole food and a real lifestyle would do the trick.

Episode 217: Automate Your Lead Generation with our FREE online course: https://go.digitaltrailblazer.com/auto-leads-course-freeMany online business owners eventually hit a wall - whether it's a profit ceiling, misalignment with their audience, or a business model that no longer feels right. Staying stuck in the wrong direction doesn't just kill momentum, it drains your energy and keeps you from building something that truly works.In this episode, Horace Dobson teaches us how to make smart decisions around rebranding and pivoting your business, including how to identify whether you're facing a real alignment problem or just a marketing fix, why finding a unique position in your market eliminates the need to compete on price, and why investing in the right mentorship is the fastest path to breakthrough results.About Horace Dobson: Horace is a registered nurse, disabled U.S. veteran, entrepreneur, and multi-genre author whose life reflects a true rags-to-riches transformation. After nearly 30 years working on hospital floors across the United States, he stepped away from traditional healthcare to found Warrior Weightloss and create Empowered AI - a consumer-focused health-intelligence platform helping people take control of their metabolism, mindset, and longevity through real-world data and accountability, not hype.Beyond business, Horace is deeply committed to service, supporting disabled veterans, foster parents, and families facing food insecurity throughout West Palm Beach County. He is also the author of multiple books spanning health, mindset, and personal transformation — including The Comeback, available free in audiobook form by searching "Horace Dobson The Comeback."Visit Warrior Weightloss here: https://www.warriorweightloss.com/Mention the Digital Trailblazer podcast for 20% off any Weight Loss medications, such as Semaglutide or Tirzepatide at https://www.360lifeshift.comConnect with Horace: Facebook - https://www.facebook.com/profile.php?id=61575535337510 YouTube - https://youtube.com/@evolifewellness?si=aj_CQ0HPM02XppAT LinkedIn - https://www.linkedin.com/in/horace-dobson-ba82a23a/ Instagram - https://www.instagram.com/theempowered.ai/Want to SCALE your online business bigger and faster without the endless hustle of networking, referrals, and pumping out content that nobody sees?Grab our Ultimate Ad Script for Coaches, Agencies, and Course Creators.Learn the exact 5-step script we teach our clients that allows them to generate targeted, high-quality leads at ultra-low cost, so you can land paying customers and clients without breaking the bank on ad spend.Grab the Ultimate Ad Script right HERE - https://join.digitaltrailblazer.com/ultimate-ad-script✅ Connect With Us:Website - https://DigitalTrailblazer.comFacebook - https://www.facebook.com/digitaltrailblazerTikTok: https://www.tiktok.com/@digitaltrailblazerX (Twitter): https://x.com/DgtlTrailblazerInstagram: https://www.instagram.com/DigitalTrailblazer

GLP-1 drugs like Ozempic and Mounjaro are now everywhere. But what do they actually do beyond weight loss? And what do you need to know before starting them? In this episode, we're joined by Dr Ania Jastreboff, a world-leading researcher at the forefront of GLP-1 treatments and writer of the New York Times bestselling book Enough: Your Health, Your Weight, and What It's Like To Be Free, co-authored with Oprah Winfrey. Dr Jastreboff explains everything you need to know about Ozempic, Mounjaro, Wegovy and other GLP-1 medications for 2026. You'll learn how GLP-1s may reduce the risk of heart disease, improve blood sugar control, and support conditions like sleep apnoea. We also explore why weight often returns after stopping, and what you need to know about Ozempic side effects and long-term use. If these drugs can change how your brain controls hunger, what does that mean for willpower, weight gain, and how we treat obesity long term?

Dr. Mindy joins us in-studio to talk about what's wrong with Joey. And then she answers questions about Osteoporosis, the new Wegovy pill, NAD+, , Dr. MIndy is a calming goat, Collagen, Tirzepatide, Ear infections, allergies, anxiety while driving on the highway, testosterone, perimenopause, high heart rates at a young age and bunion. https://www.youtube.com/@TheDrMindyExperiment/videosSee omnystudio.com/listener for privacy information.

Three years ago, GLP-1 peptides were barely being talked about in the midlife women's health space. Since then, Jessica and I have personally used them, experimented with different approaches, and helped over a thousand women inside our peptide program navigate what works, what backfires, and what women in perimenopause and menopause need to know before jumping in. In this episode, we're pulling back the curtain on our own GLP-1 journeys, including my rough start with Ozempic, why Tirzepatide worked better for me, Jessica's experience with Semaglutide and fatigue, and why Retatrutide is becoming one of the most talked-about peptides right now. We also get into one of the biggest myths floating around online: that GLP-1s automatically cause massive muscle loss. The truth is much more nuanced. We talk about the biggest mistakes we see women making. How Glp1s can impact insulin sensitivity, inflammation, fat cell biology, blood sugar regulation, liver metabolism, and even brain reward pathways. We also dive into some of the peptides we're loving right now beyond GLP-1s, including NAD, KPV, MOTS-c, and Tesamorelin, and why peptide therapy can be powerful when it's used intelligently, not recklessly. This is a real, honest conversation about how to use these tools in a way that supports long-term health, metabolism, muscle, and hormones, instead of chasing fast weight loss at any cost. In this episode, we cover: Our personal three-year journey using GLP-1 peptides Why Ozempic, Semaglutide, Tirzepatide, and Retatrutide can feel very different The truth about GLP-1s and muscle loss Why appetite suppression is not the only sign a GLP-1 is working The biggest mistakes women make with dosing and titration Why protein, amino acids, digestion, and strength training matter so much How GLP-1s may support insulin sensitivity, inflammation, blood sugar, and metabolic health Why some women don't lose weight until thyroid, hormones, food sensitivities, or inflammation are addressed What we're seeing with Retatrutide and why it's getting so much attention Peptides beyond GLP-1s, including NAD, KPV, MOTS-c, and Tesamorelin Who This Episode Is For This episode is for women in perimenopause or menopause who are using GLP-1s, thinking about starting them, or wondering why they are not getting the results they expected. It is especially helpful if you are worried about muscle loss, hair shedding, fatigue, dosing, long-term use, maintenance, or whether peptides are actually supporting your metabolism or just helping you eat less.     Sponsors Join our FREE upcoming masterclass: Why Midlife Weight Gain Won't Budge A smarter way to use GLP-1s in midlife without wrecking muscle or metabolism When: April 30th 11 am PST Register here: https://coaching.karenmartel.com/glp1-masterclass    Add MitoQ Hormonal Metabolic Support to your midlife support toolbox: www.mitoq.com/karenmartel get 10% off your order with code: MARTEL10     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Most disciplined executives and entrepreneurs aren't struggling with fat loss because of effort or willpower. They're struggling because they're out of sequence—jumping straight to peptides, compounds, and advanced protocols before the three biological levers that actually drive fat loss are even stable.In this episode, Julian Hayes II breaks down the exact three mechanisms that determine whether your body gets lean and stays lean—and how to pull each one in the right direction before layering in anything advanced.You'll walk away understanding why fat loss is a sequencing problem, not a knowledge problem, and what it actually looks like to build a metabolic foundation that performs the way your business does. For executives and entrepreneurs operating in high-stakes environments, this episode connects biology directly to business performance.— Episode Chapter Big Ideas (timing may not be exact) —0:00 – Why disciplined high performers still don't look the part 1:57 – The three biological levers behind sustainable fat loss2:51 – About Julian and Executive Health3:26 – Who this conversation is actually for 4:49 – Lever 1: Nutrient Partitioning: where do your calories actually go?6:04 – The capital allocation analogy: investing in lean tissue vs. storing fat6:50 – The four factors that determine partitioning efficiency12:26 – Practical foundation: how to optimize partitioning before going advanced13:19 – Earning your carbs: the Charles Poliquin philosophy15:30 – GLP-1 receptor agonists and nutrient partitioning15:49 – Testosterone and hormonal optimization: Why hormones make everything go18:06 – Lever 2: Recovery Signaling: Where most high performers self-sabotage19:09 – What recovery signaling actually controls in a deficit19:33 – Cortisol21:02 – Growth hormone22:07 – Thyroid conversion: the T4 to T3 problem nobody talks about24:15 – HRV: your autonomic nervous system's engine light27:07 – Practical recovery: sleep timing and maximizing slow-wave GH pulses28:53 – Protein in a deficit: the primary defense against muscle loss29:39 – Electrolytes, magnesium, and why micronutrients matter more on GLPs32:51 – Advanced layer: CJC-1295 and Ipamorelin34:17 – Exogenous HGH: beyond bodybuilding34:54 – BPC-157 and TB-500: the gateway peptides for recovery35:58 – The 90/95 rule: foundation is the work, advanced tools are the amplifier36:34 – Lever 3: Appetite and Energy Regulation: the compliance lever37:22 – Why fat loss is a compliance problem, not a knowledge problem37:34 – Food noise is biological, not psychological38:51 – What poor appetite regulation actually costs executives40:24 – How aggressive deficits suppress testosterone41:15 – Performance as the feedback loop for energy regulation43:00 – Fiber, gut health, and natural GLP-1 secretion44:06 – Meal timing and circadian biology46:52 – Advanced layer: Semaglutide, Tirzepatide, and Retatrutide explained50:30 – Muscle loss, GI risk, and why lifestyle habits are the real variable51:24 – Genetics and fat loss52:47 – Low-dose Naltrexone54:19 – Thymosin Alpha-1 and emerging peptide research on energy regulation55:36 – Tying it all together: Foundation First, Amplification Second57:01 – The cost of skipping a sequence59:05 – The executive case for fat loss beyond aesthetics1:01:30 – How to work with Julian privately— Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/X — https://x.com/thejulianhayesReady to take your health, leadership, and performance to the next level? Book an exploratory call —https://www.executivehealth.io/contactWebsite — https://www.executivehealth.io/***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Consult your provider before making any decisions.

Major disruption hits the GLP-1 landscape as another large 503B compounding pharmacy halts production of semaglutide and tirzepatide. In this episode, we unpack what's driving the FDA's increased enforcement and why these shutdowns could signal a broader shift in the compounded medication market.Joined by Sabina Hemmi from glpwinner.com, we break down the key differences between 503A and 503B pharmacies, what these changes mean for supply and patient access, and why delays in prescriptions may be on the horizon. We also dive into the growing legal battles between pharma companies and telehealth providers and what that could mean for the future of affordable GLP-1 options.If you're using or considering compounded GLP-1s, this episode covers what you need to know right now and what could be coming next.

Microdosing GLP-1 agonists can create powerful shifts in your body—when they're used the right way. The problem? Most people (and even many doctors) are using them as a quick-fix weight loss tool. And when that's the approach, of course you see burnout, terrible side effects, and rebound weight gain. But that doesn't mean these compounds are the problem. It means the strategy is. When used in a microdosing approach, GLP-1 agonists can support your body on a much deeper level—helping improve insulin sensitivity, reduce inflammation, and calm an overworked nervous system. Especially if your body has been stuck in chronic stress or survival mode, this can be the missing piece that allows your system to finally feel safe enough to function differently. This isn't about forcing weight loss. It's about creating the internal environment where your body can release it. You don't have to stay on these forever. You don't have to suffer through harsh side effects. But you do need a more intentional, supportive approach. In this episode, I'll show you what that actually looks like. When you're ready to release the extra weight for good—and finally support your nervous system, metabolism, and relationship with food—it's time to have a conversation. Schedule your free consultation to explore what working together could look like, and whether my 3-part process is the right fit for you. www.bodyyoucrave.com/schedule  Chapters (00:00:02) - Hungry for Love(00:00:26) - Gaining Weight With GLP1s(00:06:21) - Turning off your brain: The process(00:06:56) - Tirzepatide and Semaglutide:(00:12:39) - Microdose for Perimenopausal and Menopausal Women in Their 60(00:21:04) - How to Lose Weight With a Strategic Approach(00:22:06) - Pregnant women on GLP1s(00:29:58) - How to manage emotional eating with GLP1(00:33:17) - How to Break the Cycle Around Binge Eating

When Penn Holderness described APOE4 as a “ticking time bomb,” it struck a nerve for a lot of people, especially women in midlife who already feel vulnerable about their brain health.Could a GLP-1 medication protect your brain if you carry the APOE4 gene? Amy unpacks the science in plain English and explains why genes are not destiny, why menopause changes the conversation for women, and what research-backed actions you can start taking right now.What to Listen For[00:00] Why Penn Holderness's APOE4 reveal sparked such a big reaction [02:30] What it actually means to carry one or two copies of the APOE4 gene [05:30] Why APOE4 is a genetic predisposition, not a verdict [08:30] The critical difference between APOE4 and the rare genes that directly cause early-onset Alzheimer's [10:30] Why midlife and postmenopausal women may face a different level of APOE4-related risk [14:00] How fear drives people toward quick-fix solutions and why that matters in Alzheimer's prevention [18:00] What the observational GLP-1 research shows and the big caveat most people miss [22:00] What the EVOKE and EVOKE Plus semaglutide trials found in people with early Alzheimer's symptoms [25:30] What hormone therapy can do for sleep and symptom relief — and what it has not been proven to do for dementia prevention [28:30] Why the FINGER study, U.S. POINTER, and modifiable risk-factor research offer the most hopeful path forward [32:30] The free RESTORED guide, the 8 evidence-based lifestyle factors, and Amy's call to take action without panicIf you've been feeling afraid of your genetic risk, this episode is your reminder that APOE4 is not destiny. Amy explains why the most powerful path forward is still grounded in the basics: sleep, movement, metabolic health, stress management, and consistent daily choices. Listen now, subscribe to the show, and grab Amy's free guide so you can start protecting your brain one step at a time.From The EpisodeDownload the free RESTORED ProtocolBook your Breakthrough Roadmap sessionResearch cited in this episode:1. NIA Alzheimer's Disease Genetics Fact Sheet — APOE4 prevalence and risk breakdown https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet2. Altmann A et al. (2014). Sex modifies the APOE-related risk of developing Alzheimer disease. Annals of Neurology. https://pmc.ncbi.nlm.nih.gov/articles/PMC4117990/3. Stanford Medicine (April 2026). Women get Alzheimer's more often than men: Five things the science tells us. https://med.stanford.edu/news/insights/2026/04/women-alzheimers.html4. Alzheimer's Association (2025). Statement on oral semaglutide phase 3 topline data (EVOKE/EVOKE+ trials). https://www.alz.org/news/2025/alzheimers-assRESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

Hear the latest on PCSK9 inhibitors, cardiorenal benefits of GLP-1 drugs, and other clinical research in this interview with Katie Berlacher, MD, MS, chair of this year's annual ACC meeting. Related Content: PCSK9 Inhibitors in Diabetes, Tirzepatide's Cardiorenal Effects, Shingles Vaccine, and More From ACC

Welcome to Ozempic Weightloss Unlocked, where we dive into the latest on Ozempic, from medical breakthroughs to lifestyle impacts.Listeners, big news from the British Heart Foundation: over one million people with cardiovascular disease will soon get Wegovy, which contains semaglutide like Ozempic, on the National Health Service to prevent heart attacks and strokes. The National Institute for Health and Care Excellence recommends it for those with a body mass index of twenty-seven or higher who have had a heart attack, stroke, or severe artery issues. Clinical trials show it cuts cardiovascular risks, independent of weight loss, and it's given as a weekly injection with diet and exercise.The Obesity Medicine Association reports that in December twenty twenty-five, the Food and Drug Administration approved an oral Wegovy pill for obesity, starting at one point five milligrams and titrating up. It matches the injectable's side effects like stomach issues but offers a no-needle option, taken on an empty stomach.Tirzepatide, sold as Zepbound, leads in effectiveness per their data, with up to twenty-two point five percent average weight loss in trials, beating semaglutide's fourteen point nine percent. Expect one to two new GLP-one drugs yearly from twenty twenty-six, like Lilly's orforglipron oral pill showing eleven point two percent loss, and Novo Nordisk's amycretin with twenty-four point three percent in phase two.Beyond weight, Advisory Board notes semaglutide's approvals for chronic kidney disease in type two diabetes patients and cardiovascular benefits, reducing major events by twenty percent. Studies link it to lower cognitive decline risks and possible fertility boosts from weight loss improving hormones.Always pair these with healthy eating, exercise, and behavioral changes for best results and to preserve muscle.Thanks for tuning in, listeners. Subscribe for more updates. This has been a Quiet Please production, for more check out quietplease.ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

In this episode, we discuss the most important annual updates in the American Diabetes Association Guidelines, Standards of Care 2026, particularly focusing on changes in pharmacotherapy recommendations and the supporting evidence. Key Concepts A few existing agents now have ASCVD risk reduction data in patients with existing ASCVD or high indicators for ASCVD. They are: oral semaglutide and tirzepatide.  SGLT2is are still first-line in patients with diabetes and HF including HFpEF, but SC semaglutide and tirzepatide are now recommended for those with symptomatic HFpEF and obesity due to positive outcomes in this population. The GLP-1RA and dual GLP-1/GIP RA are the preferred agents for weight management in patients with T2DM, but use of GLP-1RA can be considered for weight loss in patients with T1DM. The guideline also better defines recommendations for medication-induced hyperglycemia from immune checkpoint inhibitors, PI3Kɑ (phosphoinositidylinositol 3-kinase α) inhibitors, mTOR inhibitors, and steroids.  References American Diabetes Association. Standards of care in diabetes—2026. Diabetes Care. 2026;49(suppl 1):S1-S377. SOUL study. Darren K. McGuire, Marx N, Mulvagh SL, et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med. 2025;392(20):2001-2012. doi:10.1056/NEJMoa2501006. SURPASS-CVOT. Nicholls SJ, Pavo I, Bhatt DL, et al. Cardiovascular outcomes with tirzepatide versus dulaglutide in type 2 diabetes. N Engl J Med. 2025;393(24):2409-2420. doi:10.1056/NEJMoa2505928. SUMMIT. Packer M, Zile MR, Kramer CM, et al. Tirzepatide for heart failure with preserved ejection fraction and obesity. N Engl J Med. 2025;392(5):427-437. doi:10.1056/NEJMoa2410027. STEP-HFpEF. Kosiborod MN, Abildstrom SZ, Borlaug BA, et al. Semaglutide in patients with heart failure with preserved ejection fraction and obesity. N Engl J Med. 2023;389(12):1069-1084. doi:10.1056/NEJMoa2306963. STEP-HFpEF DM. Kosiborod MN, Petrie MC, Borlaug BA, et al. Semaglutide in patients with obesity‑related heart failure and type 2 diabetes. N Engl J Med. 2024;390(15):1394‑1407. doi:10.1056/NEJMoa2313917.

Send us Fan Mail We finally made it to Dallas, and let's just say the Big D stood for more than just the city name. In this episode, we're peeling back the foil on our own incompetence—specifically how we've been winging our medical prescriptions while trying to maintain a 10/10 aesthetic. We're diving into the "Modern Grime" of our travel habits, from the "Cornhole Lesbians" of Texas to the absolute panic of a self-driving car that almost ended it all before we even reached the hotel. It's honest, it's messy, and it's the definitive proof that we are "Not Well." The Top 10 Chaotic TakeawaysThe Dosage Disaster: Realizing you've been taking a fraction of the intended dose for months while wondering why you hit a weight loss plateau.Dallas vs. The World: Surviving a trip to Texas that included questionable navigation and even more questionable life choices.The Self-Driving Death Trap: A harrowing encounter with a Tesla that decided a 90-degree horizontal turn in construction was "the vibe."Cornhole Lesbians: Being validated by the most unexpected demographic in a Dallas bar and immediately feeling "pretty."The "Hotspot" Shower: Redefining hygiene as a tactical strike on specific body parts when time (and energy) is running low.Medical Non-Compliance as Art: Treating prescription instructions like the "Terms and Conditions" page—just scrolling to the bottom and clicking "agree."The 3 AM Alfredo Pipeline: The inevitable journey from a night out to a bowl of pasta that you definitely didn't need but absolutely deserved.Lanyard Loathing: A deep-seated hatred for conference lanyards and the "dorky" energy they bring to an otherwise high-fashion aesthetic.The Korean Spa Revelation: Navigating the vulnerability of a spa day while trying to maintain the "Hot but Chaotic" hierarchy.Rebranding the Mess: Launching a new, professional logo while simultaneously admitting your life is currently a beautiful, grainy, indie-film disaster.Support the showAs always you can write us at nowellpodcast@gmail.com or call us at ‪(614) 721-5336‬ and tell us your Not Wells of the week InstagramTwitterBobby's Only FansHelp us continue to grow and create amazing content, like a live tour or just help fund some new headphones when needed. Any help is appreacited. https://www.buzzsprout.com/510487/subscribe#gaypodcast #podcast #gay #lgbtq #queerpodcast #lgbt #lgbtpodcast #lgbtqpodcast #gaypodcaster #queer#instagay #podcasts  #podcasting #gaylife  #pride #lesbian #bhfyp #gaycomedy #comedypodcast #comedy #nyc #614 #shesnotdoingsowell #wiltonmanor #notwell

Program notes:0:38 Migrating biopharma industry1:36 Early stage development2:36 Need to replicate studies3:23 Treatment for fatigue from long Covid4:25 Fluvoxamine or metformin5:25 Only fluvoxamine helped6:25 Only for fatigue6:35 How treatments for hepatitis C have been used7:36 Number of people receiving treatment declining8:36 Need a better system9:16 Dulaglutide or tirzepatide and patient reported outcomes10:17 Quality of life metrics11:43 End

Hunter Williams answers your March 2026 submitted questions across six categories — GLP-1s, growth hormone secretagogues, healing & injury recovery, metabolic peptides, men's health, and autoimmune support.Topics covered in this episode:Tirzepatide at max dose (15mg) — what to do when you've plateaued and how to transition to retatrutide safelyRetatrutide side effects — nausea, gut shutdown, sensitivity after restarting, and dose adjustmentsStacking tirzepatide and retatrutide — why it's not dangerous and the strategic reason to combine themCagrilintide + tirzepatide for appetite suppression and A1C managementGLP-1 non-responders — why some people don't respond and what to use insteadJardiance (SGLT2) alongside retatrutide — red blood cell considerations and cyclingBest peptide stacks for muscle building and body recomp on GLP-1sTesamorelin vs CJC-1295/Ipamorelin for belly fat and visceral fat reductionHGH vs peptide secretagogues for women 55+ — longevity, muscle, and brain healthGH secretagogues for female athletes with RED-S and absent menstrual cycleBPC-157 and anhedonia — dopamine effects and alternatives (TB-500, Cardilax, PEG-MGF, GHK)Pre and post-op peptide protocols for faster surgical recoveryMOTS-c, methylation mutations (MTHFR/COMT), and why some people feel more fatigued5-Amino-1MQ stacked with retatrutide — dosing caution and injectable vs oralMethylene blue, 9-ME-BC, Adamax, and Semax as nootropicsPeptides for hypothalamus and pituitary repair after brain tumor removalSelank, Noopept, and oxytocin for social anxiety and confidenceThymosin Alpha-1 for autoimmune disorders like lupusPost-prostatectomy libido restoration — testosterone, DHT, estradiol, and provironUrolithin-A and spermidine dosing for mitophagy and autophagyJoin the Axion Collective for live coaching calls every Thursday at 8PM Eastern. Submit your questions for next month's Q&A via the link in the description.Website: ⁠⁠https://hunterwilliamshealth.com/⁠Get my FREE Cheatsheet: https://hunterwilliamshealth.com/peptidecheatsheetJoin My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠⁠

Weight Loss Drugs: Tirzepatide vs Semaglutide vs Retatrutide, Peptides for Inflammation, Dracula, Scream 7 Review by Tommy McElroy

GLP-1 medications like Ozempic, Wegovy, and Tirzepatide are becoming increasingly popular for rapid weight loss - but are they the right solution for active women who care about body composition, strength, and long-term sustainability?In this episode, we break down what these medications actually do, who they're designed for, and the potential risks that often get overlooked - especially for women 35+ navigating fat loss, performance, and hormone changes.This is not about fear or judgment- it's about understanding the full picture so you can make informed decisions about your body.What You'll Learn in This EpisodeWhy GLP-1 medications are so appealing for fat lossWhat these drugs actually do in the body (and what they don't do)Who truly benefits most from GLP-1 medicationsThe difference between adherence vs dependenceThe risk of muscle loss during rapid weight lossHow under-eating can negatively impact performance and recoveryWhy many women experience rebound weight gain after stoppingThe return of hunger and food noise post-medicationThe difference between correlation vs causation in hormone and inflammation improvementsWhy appetite suppression doesn't replace the need for nutrition and behavior skillsThe long-term sustainability and financial considerations of GLP-1 useWhen these medications can be helpful (when used appropriately)Key TakeawaysGLP-1 medications do not directly burn fat—they reduce appetite, making it easier to maintain a calorie deficitWithout intentional strength training and adequate protein intake, muscle loss is a real riskMany of the “benefits” people report (better hormones, less inflammation, more energy) are largely due to weight loss itself—not the drugIf no sustainable habits are built, coming off these medications often leads to rebound weight gain and return of food noiseLong-term success comes from building skills—not relying on appetite suppressionWho These Medications May Be Appropriate ForIndividuals with Type 2 diabetesThose with obesity and significant metabolic dysfunctionIndividuals struggling with severe food noise or binge eating patternsFor others—especially active women focused on body composition—there may be more sustainable and effective long-term approaches.References & ResearchWilding JPH, et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine.Jastreboff AM, et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine.Weinheimer EM, Sands LP, Campbell WW. (2010). A systematic review of the effects of weight loss on lean body mass in older adults.Murphy CH, et al. (2014). Higher protein intake preserves lean mass during weight loss in older adults.Hall KD, et al. (2016). Persistent metabolic adaptation following weight loss and implications for weight regain.

On The Pen breaks down the latest GLP-1 news, compounded semaglutide updates, tirzepatide controversy, FDA and DDC list developments, Novo Nordisk findings, Eli Lilly B12 tirzepatide concerns, and new oral obesity drug data from Structure Therapeutics. If you follow obesity medicine, weight loss drugs, peptide news, semaglutide, Zepbound, Wegovy, Ozempic, Mounjaro, and patient advocacy, this episode is for you.WAYS TO SUPPORT MY WORK ⬇️http://www.otplinks.com00:00 Massive compound shakeup00:00:43 Why compound users need this00:01:25 Sponsor, Shed obesity care00:02:11 Breaking news changed everything00:02:28 OTP semaglutide exclusive00:03:28 DDC list explained00:04:24 Novo's lab findings00:09:57 302% dose shocker00:13:03 Catalent's contamination mess00:16:33 Lilly's B12 tirzepatide bombshell00:19:34 Is the molecule changing?00:21:46 New oral GLP-1 contender

In this episode, I'm back with Curtis Gillespie Sayers, and we dig into why GLP-1s don't always work the way people hope, especially for women in their late 30s, 40s, and beyond. Curtis shares insights from years of working with clients in functional nutrition and explains how things like metabolic adaptation, hormone shifts, gut issues, chronic stress, and not-so-great nutrition can all get in the way of these medications doing their job. Plus, he offers insights and solutions to help your GLP-1 work better. Here's what you'll learn: - Why GLP-1 medications work for some people and not for others - The surprising reason many people hit a weight loss plateau on GLP-1s - What damaged GLP receptors have to do with stubborn weight loss - Why being in a chronic calorie deficit can actually make fat loss harder - The metabolic cascade that happens when cortisol rises and thyroid function drops - The overlooked role of digestion, stomach acid, and bile when using GLP medications - Why some people experience hair loss, gallbladder issues, or pancreatitis on GLPs - The real reason some people get more food noise and hunger while taking GLPs - Why microdosing GLPs may create better metabolic stability than large weekly doses - The surprising reason losing fat can increase your body's toxic burden - What actually determines whether you can come off a GLP without regaining weight - The peptides Curtis prefers for metabolism support and fat loss (and the popular one he strongly dislikes) - The real story behind “plant peptides,” oral GLP drops, and supplements all over social media Peptide School starts March 26th! https://www.carrotsncake.com/peptideschool Semaglutide: https://elliemd.com/microdose?bp=tinahaupert Tirzepatide: https://elliemd.com/microdose?bp=tinahaupert Retatrutide: https://ignitepeptides.com/product/retatrutide-10mg/ref/tina@carrotsncake.com/ 5 Amino 1MG: https://go.biolongevitylabs.com/SH5p SS-31: https://www.realpeptides.co/products/ss-31-elamipretide/ref/220/ NTFactor: https://rstyle.me/+8Ew__ObarZQHyPfm0EDA4g Connect with Tina Haupert: https://carrotsncake.com/ Facebook: Carrots 'N' Cake https://www.facebook.com/carrotsncake Instagram: @carrotsncake https://www.instagram.com/carrotsncake YouTube: Tina Haupert https://www.youtube.com/user/carrotsncake About Tina Haupert: Tina Haupert is the owner of Carrots ‘N' Cake as well as a Certified Nutrition Coach and Functional Diagnostic Nutrition Practitioner (FDN-P). Tina and her team use functional testing, peptides, and a personalized approach to nutrition to help women find balance within their diets while achieving their body composition goals. Connect with Curtis Gillespie Sayers: https://lifestylempowerment.ca/ Facebook: https://www.facebook.com/1lifeestyleempowerment/ Youtube: https://www.youtube.com/@curtisfunctionalhealthcoach Instagram: https://instagram.com/that.coach.curtis About Curtis Gillespie Sayers: From a young age I was in and out of the hospital suffering from health complications for as long as I can remember, breathing difficulties being the most apparent but as I grew older more serious issues began to come to light. I was diagnosed with an extremely severe case of sleep apnea, high blood pressure, high cholesterol, and a pre-diabetic status. At this time, I was also struggling with substance abuse, which would obviously contribute to my health complications, but most were from birth. After receiving the news from running tests, the doctors had informed me that I was lucky to be alive. My psychological health was greatly impacted by my physiological health, evoking feelings of anger, and negativity which caused me to constantly argue with people around me. This affected several of my relationships and was creating a miserable life. This lead me to seek out the help of a bodybuilding coach (not knowing a damn thing about health at the time). The main focus was “getting shredded,” not understanding how much internal health affects one's physique.

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If the words “formal dress shopping” make your stomach drop, you're not alone.In this episode, I'm talking about the very real emotional scars that can come from being the “fat girl” when it comes to clothes, especially formalwear. From prom dresses to bridesmaid fittings to even shopping for my own wedding gown, I share the comments, judgments, and experiences that still echo in my mind every time I walk into a dressing room.And here's the thing: my body was different sizes in each of those moments. But the shame and anxiety followed me anyway.We'll talk about why those experiences stick with us, how the dressing room becomes a place of judgment instead of celebration, and the truth many of us need to hear: our bodies were never the problem.If shopping for clothes still brings up old feelings, this episode is for you! Show Notes

In this episode of the Inspire Health by Jen Podcast, Dr. Jen tackles one of the most persistent taboos in wellness: genital herpes. Moving beyond the "fifth-grader" giggles and cultural shame, she reframes the virus as a common chronic condition—much like the flu or an autoimmune flare—that simply happens to live in a sensitive area. Dr. Jen explains that while the virus remains in the body, you don't have to live in a cycle of fear or constant outbreaks. By addressing the "terrain" of the body through specific nutrition, nervous system regulation, and the "magic bullets" of bioidentical hormones and peptides, she provides a roadmap for putting the virus into long-term remission and reclaiming your confidence. Themes: Understanding why society shames genital herpes while ignoring other herpetic viruses like Mono or Shingles. How to "starve" viral expression by removing inflammatory triggers like gluten, dairy, and seed oils. Why stress and trauma in the sacral area can trigger outbreaks and how to heal the energetic "leak." The protective role of Estrogen and Progesterone in maintaining tissue integrity and immune resilience. A look at "magic bullets" like Tirzepatide for inflammation and BPC-157 for tissue repair. Understanding how antivirals work as a "bridge" rather than a root-cause solution. Connect with Jen: 

Is obesity really just about eating too much — or is something deeper driving it? In this episode, we sit down with Dr. Yasmine Elamir to unpack the concept of “diabesity” — the intersection of insulin resistance, blood sugar regulation, and chronic overeating. We explore how glucose swings influence hunger, why many people struggling with weight may have underlying insulin resistance, and how muscle, sleep, and diet can improve metabolic health over time. We also take a thoughtful look at GLP-1 medications, why some patients stall on them, and the biggest mistakes people make when relying on medication without addressing behavior and lifestyle. Dr. Elamir explains how to interpret glucose patterns, determine carb tolerance, and break emotional eating cycles using practical strategies. If you want a deeper understanding of the biology and behavior behind modern obesity, this episode delivers a clear, evidence-based perspective. Coach Vinny Email: vinny@balancedbodies.io Instagram: vinnyrusso_balancedbodies Facebook: Vinny RussoDr. Eryn Email: dr.eryn@balancedbodies.io Instagram: dr.eryn_balancedbodies Facebook: Eryn StansfieldDr. Yasmine Elamir YouTube: http://www.youtube.com/@diabetes_MD Instagram: diabetes_mdLEGION 20% OFF CODE Go to https://legionathletics.com/ and use the code RUSSO for 20% off your order!

The other night, I was at the ER with Javi until 4 am. By the time I got home, the temptation to cancel everything and stay in bed was very real.But with just a few hours of sleep, I still got up, got ready, did my makeup, and showed up for the day.In this episode, I'm talking about the idea of “never looking like what you're going through.” Not in a performative or toxic way, but in the sense of refusing to abandon yourself during hard moments. Sometimes the smallest acts of care, from washing your face, getting dressed, and keeping a routine, are what carry us through the chaos.Show Notes

In this episode of the Flex Diet Podcast, I sit down with my good friend John Gorman to unpack the current “wild west” of peptides, TRT, GLP medications, and performance-driven bloodwork. We dig into how John's telemedicine clinic approaches comprehensive lab testing — and why running a full panel (including markers like reverse T3) matters far more than cherry-picking a few numbers. If you've been dieting hard, training consistently, and still feeling stuck, we break down how chronic stress, poor recovery, and subtle hormone disruptions can quietly crush metabolism and make fat loss feel like a white-knuckle grind. We also cover testosterone replacement therapy (TRT) — the real pros and cons, common oversimplifications in the industry, and what most clinics fail to discuss. From there, we dive into GLP-1 medications and tirzepatide, what we currently know, what we don't know about long-term use, and how to think critically about risk versus reward. John shares practical guidance on legitimate peptide sourcing, red flags to watch for, and how to think about “periphery” tools like methylene blue and injectable carnitine without getting sucked into hype. If you're interested in optimizing performance, improving body composition, or simply making smarter decisions in a rapidly changing medical landscape, this episode will help you separate signal from noise. Sponsors: Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:20 Johns Telemed Launch 05:15 How Lab Consults Work 08:23 Coaches and Bloodwork Ethics 13:25 Reverse T3 Explained 16:56 Stress Hormones and Dieting 20:08 Microdosing Tirzepatide 26:30 Long Term GLP1 Concerns 30:45 TRT Done Right 33:10 Better Clinics Better Consumers 35:56 Vetting Coaches and Clinics 37:40 Peptides Wild West 38:50 Spotting Bunk Peptides 41:22 Legit Sources and Protocols 42:30 Evidence vs Hype 45:17 How to Verify Quality 50:54 Which Peptides Matter 54:14 Methylene Blue and Carnitine 57:50 Dosing and Safety Notes 01:02:06 Wrap Up and Recommendations 01:04:03 Music Picks and Outro 01:07:07 Final Disclaimers  Flex Diet Podcasts you may enjoy: Episode 319: Exploring the World of Peptides with Anthony Castore YouTube: https://www.youtube.com/watch?v=RbTY6kRP1H4&t=11s Episode 212: The Pros and Cons of Training Elite Level Professional Athletes: An Interview with Dr. Andy Galpin YouTube: https://www.youtube.com/watch?v=rf1imcUu-Ew Connect with John: Instagram: https://www.instagram.com/team_gorman YoulTube: https://www.youtube.com/@TeamGormanPhysiqueEnhancement Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

The State of Hormone & Peptide Industry with Phil Vela Disrupting the health & wellness industry. (2:15) "It's that hard to do IT, so it's that easy to succeed once you've done IT." (2:48) What he did before he started Vita Bella, and the origins of the company. (5:00) The most applicable skills gained from his previous career. (7:41) Calling out the 'Grey Market' and its competition. (9:44) The state of the peptide industry and the fallout with Transcend. (15:54) Results & service. (25:23) Breaking down the Vita Bella membership package. (30:07) Businessman at heart. (33:34) Why he believes it should be illegal to prescribe GLP-1s by themselves. (35:13) Bad actors giving bad guidance. (43:33) His outlook for the future of the industry. (45:14) Will Ozempic and Tirzepatide ultimately bankrupt the United States? (53:27) The importance and value of having a trainer while on a GLP-1. (56:47) "I didn't build this business for money. I built it for a legacy!" (59:07) "Newer" peptides that have been impressed by. (1:03:16) Rapid fire: The best peptide for… (1:11:56) Related Links/Products Mentioned Visit Vita Bella for an exclusive offer for Mind Pump listeners! ** The first 50 signups will get a Vita Bella welcome box. You can finally achieve a top 1% all-around health at an affordable price! ** Get 20% off Kion at getkion.com/mindpump ** No code needed automatically applied at check out! ** MAPS Great 8 Launch - (Retail $127, Code: LAUNCH for 50% off!) ** Launch bonus include: MAPS GREAT 8 Nutrition Guide. ** Visit: http://mapsgreat8.com/  Mind Pump Store Mind Pump Hormones Facebook Private Forum GLP-1 Litigation: Compounder Sues Eli Lilly, Novo Nordisk Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Federal Court Tosses Lilly's Suit Against Strive Pharmacy: Jurisdiction Still Matters Mind Pump #2125: Heal Like Wolverine: BPC 157 with Dr. William Seeds Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Phil Vella – "Philly" (@phillyvz) Instagram Jay Campbell (@jaycampbell333) Instagram Rick Niemi (@gods.economy) Instagram Dr. William Seeds (@williamseedsmd) Instagram Peter Attia, M.D. (@peterattiamd) Instagram    

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden sits down in person with fitness and nutrition expert Autumn Calabrese to unpack the full truth about GLP-1 agonists. With millions of people jumping on semaglutide, tirzepatide, and soon retatrutide, the conversation most doctors aren't having is about what's actually happening inside the body while the scale goes down. Dr. Gladden breaks down how GLP-1s suppress hunger, slow metabolism, and trigger muscle wasting when used without proper diagnostics or a supporting protocol. He explains the critical differences between GLP-1s, GLP-2s, and GLP-3s, reveals why the ghrelin rebound causes most people to regain everything they lost, and shares the strategies he uses in his practice to help patients lose fat while protecting lean tissue. From the 5-day fasting mimicking diet to natural GLP-1 boosters like metabolic probiotics and calocurb, this episode lays out a smarter, more sustainable path to optimizing body composition. Whether you're considering a GLP-1, already on one, or looking for alternatives, this is the conversation that could change your entire approach. For Audience • Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!  • Subscribe to the Gladden Longevity Newsletter for the latest on longevity medicine, peptide protocols, and hormone optimization → https://start.gladdenlongevity.com/subscribe • Ready to find out what's really going on inside your body? Book a call with the Gladden Longevity team → https://start.gladdenlongevity.com/apply-now Takeaways • Peptides are signaling partners, not substitutes for the work your body needs to do.  • GLP-1s were designed for diabetics and metabolic syndrome, not casual weight loss. • GLP-1s decrease energy expenditure while GLP-3s (retatrutide) increase it. • Many GLP-1 users are losing muscle mass instead of fat without realizing it. • The ghrelin rebound after stopping a GLP-1 drives appetite higher than before while metabolism stays slower. • A fasting blood sugar and hemoglobin A1C alone are not enough to understand your metabolic health. • A two-hour glucose tolerance test with an insulin curve reveals insulin resistance most doctors completely miss. • The 5-day fasting mimicking diet resets ghrelin, taste buds, gut biome, and leptin sensitivity without destroying muscle. • You can boost your body's own natural GLP-1 production through the right probiotics and bitter receptor activation. • Weight gain is not always an appetite problem. Thyroid dysfunction, declining sex hormones, and missing micronutrients can all be the real driver. • Sex hormone optimization during perimenopause and andropause is critical for maintaining body composition. • Willpower never wins long term. Systems and environment design are what create durable results.    Chapters 00:00 Introduction and Welcome with Autumn 00:44 What Is a Peptide and How Peptides Work in the Body 03:07 BPC-157 and the Pharma Model vs. Peptide Signaling 05:00 You Can't Out-Peptide Bad Habits 06:31 What Is a GLP-1 and How It Affects Your Brain and Gut 08:57 GLP-1s Were Designed for Diabetics Not Weight Loss 09:40 GLP-2 Tirzepatide and GLP-3 Retatrutide Explained 11:00 Why Retatrutide Increases Energy Expenditure While GLP-1s Decrease It 12:00 The Muscle Mass Crisis on GLP-1s 14:06 The Patient Who Lost 20 Pounds of Pure Muscle 15:00 Protecting Muscle with Perfect Aminos and Creatine 17:00 Autumn's Personal Supplement Stack for Training 19:00 Food Noise Ghrelin and the Appetite Rebound 21:18 The 5-Day Fasting Mimicking Diet as a Metabolic Reset 23:00 Building Your Own Natural GLP-1 Production 25:00 The Glucose Tolerance Test Most Doctors Never Run 28:30 Risks of GLP-1s Pancreatitis Thyroid Tumors and Unsupervised Use 29:50 Microdosing GLP-1s in Perimenopause 30:30 Calocurb the Natural Appetite Suppressant from Hops 32:00 Sex Hormone Optimization for Body Composition 35:00 Resting Metabolic Rate Testing and Hidden Thyroid Dysfunction 38:00 Autumn's Hormone Health Program and Real Results 39:30 Willpower vs Systems and Architecting Your Environment 41:30 Bio-Individuality and Why Someone Else's Plan Won't Work for You 43:00 The Power of Diagnostics and Understanding Your Genetics  To learn more about Autumn: Instagram: @autumncalabrese Reach out to us at: Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw   Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

Send a textThis episode unpacks Novo's aggressive price cuts, Lilly's head to head trial win, and the emerging triple agonist race, revealing how pricing strategy and next generation data are colliding in a full scale GLP-1 market war.00:00 – Cold Open: Lilly vs Novo Shock TimingDave opens with the bombshell that Novo funded a tirzepatide trial while simultaneously announcing major price cuts to Wegovy and Ozempic, setting up a strategic chess match.03:20 – Novo Nordisk Price Cuts ExplainedDeep dive into Novo's plan to cut list prices by up to 50% and what that actually means for formulary power, PBMs, and competitive positioning.07:25 – Tirzepatide vs Semaglutide Head to Head TrialBreakdown of the direct comparison study showing stronger weight loss with tirzepatide and what that means clinically and commercially.11:55 – Market Reaction and Strategic ImplicationsDiscussion of stock movement, competitive signaling, and how Novo's pricing move may blunt Lilly's trial victory.14:25 – Novo Triple Agonist Data DropsShift into Novo's early phase data on its triple agonist candidate and how it compares conceptually to existing dual agonists.16:00 – Comparing Novo's Triple to RetatrutideAnalysis of weight loss percentages versus Lilly's retatrutide data and the caution required when comparing across trials.18:15 – The Triple Agonist EraBroader conversation about whether triple agonism consistently pushes weight loss higher and what durability may look like long term.20:00 – Clinical Trial Results vs Real World RealityReminder that clinical trial outcomes do not automatically translate to everyday patient experience.22:30 – Data Refresher on Allurion Ballon ApprovalQuick recap of the headline numbers and strategic landscape as innovation and pricing Visit TRYSHED.COM to learn more today! Use CODE OTP25 to save 25%!

I've been sick all week, and it completely disrupted my plans, my workouts, and the momentum I thought I was building.In this episode, I'm talking about what it feels like when your body forces you to rest — and why we often only “allow” ourselves to slow down when we're physically unwell. If you're feeling behind, off track, or like you have to start over, this is your reminder: you're not starting over. You're continuing.Show Notes!

This episode covers: • Real Food Reset in U.S. Dietary Policy The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they shape what eventually shows up on labels and in public institutions. He also shares how biohackers can use this shift as leverage to push for better food environments in schools, workplaces, and hospitals. -Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health • Drug Combo Extends Lifespan of Frail Old Mice by 73% A new aging study found that combining oxytocin with a compound called A5i extended the remaining lifespan of frail elderly male mice by 73%, while also improving function and tissue health. Dave explains why this is a big signal for the future of longevity medicine: stacking targeted interventions can outperform single compounds, especially when you start late in life. He also explains what to do with the idea right now: stop building random “everything stacks” and start thinking in phases, tracking outcomes, and waiting for real human combo data. -Source: https://www.futura-sciences.com/en/study-finds-drug-combo-could-slow-aging-and-increase-lifespan-by-73_23229/ • ChatGPT Health Turns Your Data Into a Health OS OpenAI launched ChatGPT Health, a dedicated health experience that lets you securely connect medical records and wellness apps like Apple Health and MyFitnessPal, so you can summarize visits, interpret labs, and prepare better questions for your doctor. Dave explains why this is a turning point for quantified self and protocol building: it reduces the friction of pulling data from five different places, and it makes pattern-finding accessible to nontechnical people. He also shares how to use it like a pro: clean inputs, smarter questions, and better doctor conversations. -Source: https://openai.com/index/introducing-chatgpt-health/ • Whole Milk Is Back in Schools The Whole Milk for Healthy Kids Act restores whole and reduced-fat milk options in schools, aligning school nutrition rules with the updated dietary guidelines that no longer treat full-fat dairy like a default villain. Dave breaks down why this matters for child healthspan: satiety and nutrient density drive behavior, learning, and metabolic stability. He also explains why this is a real-world policy experiment worth watching across school districts, and how it can open the door for bigger institutional upgrades like better protein and fewer ultra processed items. -Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/14/whole-milk-back-president-trump-signs-whole-milk-healthy-kids-act • Tirzepatide Trial Targets Biological Age With Aging Clocks A registered clinical trial titled Tirzepatide to Slow Biological Aging is using multiple DNA methylation aging clocks as primary endpoints, along with functional metrics like grip strength and a 6-minute walk test. Dave explains why this is a big maturity step for longevity science: instead of assuming metabolic improvement equals slower aging, this study is measuring biological age directly, across multiple clocks, with performance outcomes. He also shares the practical lesson for biohackers: stop relying on one favorite metric and start thinking in panels, function, and durability of results. -Source: https://clinicaltrials.gov/study/NCT07220473 All source links provided for direct access to the original research and reporting. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want practical strategies rooted in cutting-edge science. Host Dave Asprey translates emerging research into actionable upgrades for your biology, from metabolism and food policy to AI-driven tracking, institutional nutrition, and biological aging measurement. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Dietary Guidelines for Americans 2025-2030, real food policy reset, ultra processed foods policy, added sugar limits, sugary drinks guidelines, school lunch nutrition policy, SNAP WIC nutrition impact, USDA HHS dietary guidelines 2026, whole food protein guidelines, full fat dairy guidelines, oxytocin aging study, A5i lifespan extension, frail elderly mice lifespan 73 percent, combination longevity therapies, aging intervention synergy, staged longevity protocols, functional aging biomarkers, ChatGPT Health launch, OpenAI health records AI, Apple Health ChatGPT integration, MyFitnessPal ChatGPT integration, AI lab interpretation, AI doctor visit summary, quantified self AI tools, Whole Milk for Healthy Kids Act, whole milk back in schools, school dairy policy change, child satiety nutrition, school meal regulations USDA, tirzepatide biological aging trial, GLP-1 GIP longevity, epigenetic aging clocks trial, DNAmAge PhenoAge GrimAge DunedinPACE, grip strength aging endpoint, 6 minute walk aging endpoint, biological age measurement, longevity clinical trial endpoints, biohacking news update, longevity policy shifts, metabolic health upgrades Thank you to our sponsors! -BEYOND Conference 2026 | Register now at https://beyondconference.com/ -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps:0:00 - Intro0:19 - New Dietary Guidelines2:09 - Longevity Research Breakthrough3:41 - ChatGPT Health Launch5:10 - Whole Milk Returns to Schools6:29 - GLP-1 Aging Trial7:34 - Weekly Upgrade Protocol9:09 - OutroSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.