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In this week's episode, Blood editor Dr. Philippe Armand interviews Drs. Manali Kamdar and Nancy L. Bartlett on their latest review article published in Blood titled “From breakthroughs to blueprints: evolving evidence and future directions in relapsed and refractory large B-cell lymphoma”. They discuss the how the advent of chimeric antigen receptor T cells, antibody-drug conjugates, and bispecific antibodies all show major increases in efficacy over legacy chemotherapy-based regimens. They also share their insights on how to transform treatment paradigms in light of these breakthroughs.
Why do two people with Parkinson's experience the disease so differently?In this episode, we sit down with researchers Patrik Verstreken and Natalie Kaempf to explore groundbreaking work that may help answer that question. Using advanced biology, biomarkers, and artificial intelligence, their team has identified what could be five distinct biological subtypes of Parkinson's disease.We discuss what these findings mean for people living with Parkinson's today, how genetics and environmental factors may influence disease progression, and why understanding the biology behind Parkinson's could lead to more personalized treatments, better clinical trials, and earlier diagnosis in the future.Chapters00:00 Introduction to Parkinson's Disease Research02:54 Understanding the Variability of Parkinson's Disease06:07 Symptomatic Treatments vs. Underlying Causes08:57 Subtypes of Parkinson's Disease11:51 The Role of Biomarkers in Early Diagnosis14:46 AI's Impact on Parkinson's Research18:10 Clinical Trials and Treatment Stratification20:59 Future Directions in Parkinson's Disease Treatment23:55 The Importance of Community and Hope
Modern sports did not just change how people played; they fundamentally rewired how they lived, looked, and identified within a rapidly transforming world. The conversation with Murat Yildiz, an assosciate professor of history at Skidmore College, explores the high-stakes intersection of physical culture, social status, and the 19th-century quest for a new global aesthetic. Elite educational and military institutions utilized gymnastics and disciplined exercise to mold an upwardly mobile generation, using sports to reconfigure traditional social hierarchies. Meanwhile, the rise of photography helped normalize and spread a uniform corporal aesthetic, allowing young men from diverse backgrounds to adopt a standardized look of proper modern masculinity. Tracing a vibrant athletic awakening, the discussion follows how sporting culture rippled across urban centers, from Istanbul to Cairo, Beirut, and Jerusalem, signaling a deeper transformation in community, selfhood, and the shift from indigenous traditions to professionalized international play. 0:00 Introduction 1:39 Misconceptions of Athletics and Modernity 4:07 Professionalism vs. Amateurism in Regional Sporting Culture 8:41 Sports as a Tool for Capturing Urban Diversity 9:17 Educational Reformers and the Significance of Gymnastics 12:47 Sports as a New Modern Technology 18:53 Photography and the Global Corporal Aesthetic 21:56 Visual Normalization of Ethnic and Religious Identities 23:14 Sports and the Creation of New Militaries 26:13 Reconfiguring Class Hierarchies in Elite Schools 30:41 Spreading Western Sports: From Baseball to Soccer 32:21 Tension with Indigenous Traditions: The Case of Wrestling 36:40 Gendering the Ottoman World of Sports 41:04 Tracing the Regional Sports Nahda beyond the Capital 48:07 History as a Creative Conversation with the Past 52:02 Al Abtal Magazine and the Egyptian Physical Culture 56:53 Further Recommendations: Football, Books, and Film 1:01:56 Future Directions for Archival Research Murat C. Yildiz is Associate Professor of History at Skidmore College. He specializes in the cultural and social history of the modern Middle East. In particular, his research examines the intersections of sports, identity, the body, gender, and intercommunality in the late Ottoman Empire. His book, "The Ottoman World of Sports: Refashioning Bodies, Men, and Communities in Late Imperial Istanbul" (The University of Texas Press), examines how Istanbul's Muslim, Christian, and Jewish denizens created a shared sports culture during the late nineteenth and early twentieth centuries. He is an assistant editor for the Arab Studies Journal and serves as an editorial board member of the International Journal of the History of Sport. He received his Ph.D. in History from the University of California, Los Angeles and served as a Manoogian Postdoctoral Fellow in the Department of History at the University of Michigan. Connect with Murat C. Yildiz
After an extensive career in the financial industry, Matthew now serves as a key figure at Pathstone, where he leads with a commitment to integrity, strategy, and client-first solutions. In this episode, Matthew shares insights from his journey at Pathstone, diving into the firm's unique approach to wealth management and how they're reshaping the financial landscape. He discusses the lessons he has learned about building trust with clients, leading teams with purpose, and adapting to the ever-evolving financial world. Matthew also reflects on how Pathstone's client-centric model continues to drive long-term success and create lasting impact for families and institutions alike. In this episode, Darius and Matthew will discuss: (00:00) Introduction to Pathstone and Matt Fleissig (02:02) Matt's Journey: From Computer Nerd to Wealth Management (05:55) The Birth of Pathstone: Vision and Early Days (09:57) Understanding Family Offices and Pathstone's Unique Model (14:05) Client Profiles: Ultra High Net Worth and Family Offices (18:01) Innovative Services: Unbundling Wealth Management (21:47) Scaling the Business: Technology and Automation (26:00) Entrepreneurial Growth: Pathstone's Rapid Expansion (30:12) Maintaining Vision: M&A and Future Directions (30:42) Understanding Wealth Management Scale (34:06) The Evolution of Leadership in Growing Firms (35:15) Reinventing Leadership for Growth (38:32) The Role of Private Equity in Growth (40:28) Creating a Culture of Ownership (48:22) Integrating Diverse Talents and Cultures (54:34) Future Trends in Wealth Management Matthew Fleissig is the CEO and co-founder of Pathstone, The Family Office, serving families, family offices, and foundations. He leads the firm's strategic vision and innovation and serves on the Investment Oversight Committee and Executive Leadership Team. Previously, Matt was President of Pathstone and held roles at Harris myCFO and The Ayco Company, advising high-net-worth clients on investments and financial planning. Connect with Matthew: Website: https://www.pathstone.com/ LinkedIn: https://www.linkedin.com/in/fleissig/ Connect with Darius: Website: https://therealdarius.com/ Linkedin: https://www.linkedin.com/in/dariusmirshahzadeh/ Instagram: https://www.instagram.com/imthedarius/ YouTube: https://www.youtube.com/@Thegreatnessmachine Book: The Core Value Equation https://www.amazon.com/Core-Value-Equation-Framework-Limitless/dp/1544506708 Write a review for The Greatness Machine using this link: https://ratethispodcast.com/spreadinggreatness. Learn more about your ad choices. Visit megaphone.fm/adchoices
As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Ivan de Kouchkovsky discusses radioligand therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41561]
As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Ivan de Kouchkovsky discusses radioligand therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41561]
As part of the 2026 UCSF Patient Conference on Prostate Cancer, Dr. Ivan de Kouchkovsky discusses radioligand therapy. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 41561]
Get double the episodes, and keep FUT Weekly going (for just £3 a month) by becoming a Patreon over at bit.ly/morepod. This includes an exclusive supporter podcast this week! EA Principle Gameplay Designer on FC, Gili Lopes, joins your hosts Josh and Ben to discuss the latest gameplay update in FC 26 and more: Chapters (please note, as Spotify inserts ads into run time, these timestamps will usually be behind when the topics starts): 00:00 Introduction to Gameplay Changes 01:15 Understanding the Bruiser Patch 07:16 Balancing Bruiser and Enforcer Mechanics 13:48 The Complexity of Defensive Mechanics 24:32 Changes to Intercept Play Style 34:22 Exploring Gameplay Mechanics and Depth 36:45 Understanding Team Press Changes 42:10 Balancing Responsiveness and Gameplay 51:51 Future Directions in Competitive Gameplay Learn more about your ad choices. Visit podcastchoices.com/adchoices
Episode Summary In this episode of The EdTech Podcast, we explore how schools, families and EdTech providers can better support children's wellbeing, inclusion and safety in an increasingly digital world. Louise Dawson shares insights on inclusive education, personalised learning, safeguarding, data protection and the importance of belonging and connection in every learning environment. She highlights how technology can support diverse learners when implemented strategically, with clear policies, strong teacher preparation and a community-wide understanding of digital responsibility. Harrison Parker, Executive Vice President of Linewise, joins the conversation to discuss student wellbeing, screen time, digital distractions, cyberbullying, AI chatbots and the growing challenges schools and parents face in managing children's online lives. He explains how Linewise supports schools and families with tools that help monitor, manage and guide technology use, while reducing friction between children, parents and educators. Together, these conversations explore a vital question for education today: how do we ensure technology empowers learning, protects children and strengthens connection, rather than creating greater risk, distraction or exclusion? Action Items Review and update safeguarding policies to reflect current EdTech use, AI risks and digital wellbeing concerns. Ensure data protection and privacy principles are embedded into EdTech procurement and implementation. Develop a whole-school strategy for technology use that includes inclusion, safeguarding, teaching and learning, and parent engagement. Provide staff training on classroom technology management, digital distractions and emerging AI-related risks. Support parents with practical tools and guidance for managing screen time at home. Create opportunities for families, schools and students to discuss healthy digital habits together. Use data trends to identify early signs of harmful online behaviour, cyberbullying or wellbeing concerns. Embed digital literacy into the curriculum so students understand both the opportunities and risks of technology. Key Topics Digital wellbeing and student safety Inclusive education and personalised learning Safeguarding and data protection in EdTech Screen time management at home and school Digital distractions and classroom management AI chatbots, cyberbullying and emerging online risks Parental involvement in digital safety Technology as a support for diverse learners Teacher preparedness and strategic EdTech implementation Community, belonging and connection in digital education Using data to identify harmful trends and support intervention Collaboration between schools, parents and EdTech providers Guest Names Louise Dawson - Louise Dawson Professional and Management Development Training www.louisedawson.com Harrison Parker, Executive Vice President, Linewise https://www.linkedin.com/in/harrison-parker-02951921 Linewise: https://www.linewize.com/ Key Frameworks and Concepts Universal Design for Learning Data Protection Principles Digital Safeguarding Screen Time Management Digital Literacy Parent-School Partnership AI Risk Awareness Whole-School EdTech Strategy Chapter Outline 00:00 – Introduction to Inclusive Education and Digital Wellbeing Setting the scene for a conversation about EdTech, inclusion, safeguarding and student safety. 03:06 – The Role of EdTech in Supporting Learning Louise Dawson explores how technology can support diverse learners and enable more personalised learning experiences. 05:48 – Challenges in Implementing Technology in Classrooms Discussion around teacher confidence, strategic planning and the risks of poorly implemented EdTech. 08:36 – Teacher Preparedness and EdTech Integration Why training, clarity and purpose matter when introducing technology into learning environments. 11:23 – Data Protection and Safeguarding in EdTech Exploring the importance of safeguarding, privacy and accountability in digital education. 14:14 – The Importance of Community and Connection Louise reflects on belonging, inclusion and the role of relationships in supporting young people. 17:03 – Navigating Technology Use at Home How schools and families can work together to support healthy technology habits. 20:16 – Introduction to Harrison Parker and Linewise Harrison shares his journey into education and the mission behind Linewise. 23:17 – The Evolution of Technology in Education How classroom technology has changed and what this means for students, teachers and parents. 27:47 – Digital Distractions and Screen Time Challenges Exploring the impact of phones, apps and always-on access on learning and wellbeing. 30:10 – Classroom Management and Technology Integration How schools can manage devices in a way that supports teaching rather than creating friction. 32:23 – Empowering Parents with Technology Why simple, practical parental tools are essential for creating healthier digital boundaries. 34:17 – Positive Trends in Student Behaviour How monitoring and management tools can help reduce harmful events and support earlier intervention. 38:00 – AI, Cyberbullying and Emerging Online Risks The rise of AI-generated harm, voice replication, chatbots and new safeguarding challenges. 43:42 – Future Directions in EdTech and Child Safety The need for collaboration between families, schools, policymakers and technology providers. Resources UAE Law on Digital Safety – https://example.com/uae-digital-safety-law Inclusive Education Strategies – https://amazon.com/inclusive-education-strategies EdTech Safeguarding Guidelines – https://example.com/edtech-safeguarding
Send us Fan MailWe return to discuss the role of radiotherapy in the management of Pancreatic Cancer.What are the side effects of pancreatic radiotherapy and SABR?Do we need an MR Linac to deliver pancreatic SABRWhere might pancreatic RT sit alongside new RAS inhibitor therapies?Enjoy
Today's episode is a heartfelt dive into the wild, wonderful world of rural health care, featuring the utterly inspiring Tami DeCoteau. We explore everything from Native American trauma to the magic of telemedicine and, of course, the political circus affecting mental health funding. Why does Tami love her rural practice? How do social media and AI impact our minds? And what's the deal with farmers feeling more stressed than a coffee addict on decaf? Heidi and Joel also discuss upcoming Senate and governor races, focusing on Sherrod Brown's potential return to the Senate, the political landscape in Ohio, and insights into key electoral strategies. They analyze the implications of recent political developments and candidate choices, providing you with a comprehensive understanding of the current US political climate.In this episode:The explosive need for mental health services in rural and Native American populationsHow telemedicine is becoming the unsung hero in rural mental health careChallenges of attracting providers to North Dakota—money, roads, and reputationThe importance of trauma-informed care and how childhood experiences shape nervous systemsThe impact of economic stress, especially on farmers, and rising political tensionsHow social media and AI are rewiring our brains—think of it as mental cord-cutting gone wrongThe future of rural health policy (more resources, better pay, and less stigma)The missing link: the pipeline of Native American psychologists and why rural providers are hard to findPlus, a quick political roundup, because who doesn't love some political banter?Guests:Tami DeCoteau - DeCoteau Trauma-Informed Care & PracticeAnd don't forget to tell your friends, especially the ones who believe mental health is just "a phase," because Tami proves it's a lifelong mission.The Hot Dish is brought to you by the One Country Project. To learn more, visit OneCountryProject.org, or find us on Substack (Onecountryproject.substack.com), and on YouTube, Bluesky, and Facebook (@onecountryproject). (00:00) - Introduction to Rural Health Care Challenges (03:01) - The Importance of Telemedicine in Rural Areas (05:43) - Understanding the Demographics of Mental Health Clients (09:00) - Building Trust in Rural Communities (11:43) - The Impact of Trauma on Mental Health (14:52) - Economic Stress and Mental Health in Farming Communities (17:58) - The Role of AI in Mental Health (20:57) - Policy Changes for Rural Mental Health (23:27) - The Need for More Mental Health Providers (26:37) - Future Directions for Rural Mental Health Services (33:52) - Sherrod Brown's Senate Race Prospects (36:46) - Political Landscape and Implications for Ohio
Sam Brownback, the former senator, governor, and ambassador, outlines the strategic importance of religious freedom in confronting China, the role of the U.S. in supporting persecuted faith communities, and the potential for religion to influence foreign policy. The discussion with Mark Simon and Christian Whiton on "Domino Theory" highlights the intersection of human rights, national security, and moral leadership.Brownback is the author of the new book, "China's War on Faith." Chapters00:00 Introduction to the Podcast and Guest01:39 Religious Freedom as a Strategic Issue05:34 The Role of the U.S. in Promoting Religious Freedom10:48 The Vatican's Approach to China15:07 The Need for a Unified Moral Stance20:11 Retail Politics and Religious Freedom24:06 Surprises in Writing About China28:11 The Story of Jimmy Lai and Its Implications33:58 Future Directions for U.S.-China Relations
Show Notes: Peter Schmidt talks about his senior year during the Iraq War, and how the news on the problem of jobless recovery led him to consider graduate school. The Journey from Student to Dean Peter studied biomechanics at Cornell, focusing on the mathematics of biological systems and modeling clinical trials in orthopedics. He was admitted into a fellowship program in New York at an orthopedic hospital where he worked on total joint replacement. His career path led him to neuroscience, where he led clinical research and worked for a nonprofit before becoming the vice dean of a medical school. He then moved on to running clinical trials and drug development. A Focus on Parkinson's Disease Pete shares his interest in Parkinson's disease and explains that Parkinson's affects a tractable part of the brain, the basal ganglia, which is easier to model mathematically. He enjoys thinking about neuronal signaling and the microstructure of the brain, which helps in understanding the macro structure. Pete's PhD work involved modeling bone at the cellular level, and he applies similar thinking to the basal ganglia in Parkinson's disease. Research on Neurodegenerative Diseases Pete discusses the challenges in determining whether a question in neurodegenerative diseases is a question of science or engineering. He explains the historical focus on stem cells and extracellular proteins as solutions for diseases like Alzheimer's and Parkinson's. Pete emphasizes the need to understand the role of extracellular proteins and the importance of scientific inquiry. He mentions the Nobel Prize-winning discovery of prion diseases and the subsequent focus on characteristic proteins in neurodegenerative diseases, which led to initiatives focused on proteins. The Brain's Micro and Macro Structures Pete discusses the current focus on extracellular proteins and the challenges in proving their role in diseases like Parkinson's. He mentions the drug Lecanemab for Alzheimer's, which slows the disease but does not reverse it. Pete predicts that future research will focus on intracellular proteins and the need to restore lost cells in the brain. He highlights the importance of understanding the microstructure to inform the macro structure of the brain. The Logistics of Running Clinical Trials Pete explains that success in clinical trials is more about logistics than science, with 90-95% of the work being logistical. He discusses the challenges of recruiting subjects and the importance of working with academic medical centers that have a high volume of patients. Pete emphasizes the need for fast-moving ethics boards and efficient contracting to ensure the success of clinical trials. Incentives for Physicians When asked about the incentives for physicians to participate in clinical trials, Pete explains that most physicians are driven by scientific interest rather than financial incentives. He mentions the importance of academic leaders who can influence the participation of residents and fellows in trials. Pete highlights the passion of physicians in diseases like Huntington's and cystic fibrosis, which drives their engagement in research. The Role of Pharma Companies in Clinical Trials Pete talks about his role at East Carolina University where he oversaw clinical care and research at the medical school. He discusses the changing role of pharma companies in running clinical trials. He explains that many drugs are now discovered in labs, leading to a shift in the need for pharma companies to own their data. Pete mentions the issue of trial fraud, where fake patients are used to inflate data, and the importance of tighter control over trial data. He shares his experience of rescuing a trial from fraudulent data and the challenges of identifying such issues. Life on the Family Farm The conversation turns to Pete's family life, and Pete shares that his youngest child recently went to college, and he inherited a family farm that has been in his wife's family for 200 years. He enjoys working with his hands, doing woodworking, and using a skid steer for various tasks on the farm. Pete describes his role as the farm handyman, fixing things and maintaining the farm equipment. Harvard Reflections Pete mentions taking a quantum mechanics course and a material science class with X-ray interferometry. He highlights the impact of a physics class on fits and tolerances, which taught him about the importance of clearance and interference fits. Pete also shares his experience taking a folklore course with his roommate, which was his only pass/fail course at Harvard. Pete explains the concept of fits and tolerances in engineering. He discusses the importance of understanding whether a fit needs to be tight or loose and planning accordingly. Pete uses examples from finance to illustrate the principle of having a cushion in budgeting. He emphasizes the need to know the target fit (tight or loose) to optimize engineering and design solutions. This episode on The 92 Report:https://92report.com/podcast/168-peter-schmidt-from-math-to-neuroscience/ Timestamps: 02:40: A focus on Parkinson's Disease 05:10: Challenges in Neurodegenerative Disease Research 09:50: The Role of Extracellular Proteins and Future Directions 17:34: Running Clinical Trials and Logistics 27:58: Incentives for Physicians to Participate in Clinical Trials 32:16: Pharma Companies and Clinical Trial Data 38:53: Personal Life and Farming 42:30: Reflections on Harvard Courses 46:23: Fits and Tolerances in Engineering Links: https://www.linkedin.com/in/pnschmidt https://www.instagram.com/pnschmidt
On this episode of Alexa's Input (AI), I sit down with Emilio Andere, co-founder and CEO of Wafer, to talk about the future of AI infrastructure, inference optimization, and the economics driving the AI compute race.We discuss:why “intelligence per watt” may become one of the defining metrics of the AI erathe current GPU and accelerator landscape across NVIDIA, AMD, TPUs, and emerging hardware startupswhy software optimization is becoming just as important as hardware itselfinference optimization strategieswhy AI infrastructure companies are racing up the stackwhat it's actually like building an AI infrastructure startup todayand more!Emilio also shares lessons from founding Wafer, thoughts on the future of open-source AI infrastructure, and why he believes optimizing intelligence itself could become one of the most important engineering problems.General Podcast LinksWatch: https://www.youtube.com/@alexa_griffithRead: https://alexasinput.substack.com/Listen: https://creators.spotify.com/pod/profile/alexagriffith/More: https://linktr.ee/alexagriffithLearn more about the host atWebsite: https://alexagriffith.com/LinkedIn: https://www.linkedin.com/in/alexa-griffith/Find out more about the guest at:LinkedIn: https://www.linkedin.com/in/emi-andere/Wafer Website: https://www.wafer.ai/Wafer AI / Y Combinator Article: https://www.ycombinator.com/companies/waferChapters00:00 Exploring AI Conversations and Recent Podcasts02:14 Intelligence per Watt: A New Metric for AI07:35 The Manifesto: Efficiency in Civilization12:40 Founding Wafer: The Journey Begins18:08 The GPU Hardware Landscape and Market Dynamics23:07 AMD's Growing Presence in the GPU Market24:07 Emerging Competitors in the AI Hardware Space26:04 Comparing TPUs and GPUs27:21 Acquisition and Availability of TPUs28:33 Navigating the GPU Marketplace30:05 Understanding Neo Cloud Economics33:30 The AI Bubble Debate36:25 Optimizing AI Models for Performance44:46 Bottlenecks in AI Model Performance48:08 Future Directions in AI Hardware Optimization54:39 Balancing Speed and Cost in AI Performance56:54 Kernel Arena: Benchmarking AI Performance01:03:45 Lessons from Founding: Sales and Emotional Resilience01:07:38 The Future of AI: Trends and Predictions01:13:03 Outro KeywordsAI hardware, inference optimization, intelligence per watt, GPU market, AI infrastructure, Wafer, AI bubble, TPU, GPU bottleneck, AI efficiency AI optimization, large language models, AI hardware, quantization, speculative decoding, benchmarking, AI infrastructure, model training, AI startups
In this episode Ed interviews Dr. José González-Acuña, recent Ph.D. graduate at Iowa State University. They discuss José's Thesis work on frogeye leaf spot and efforts to expand the ever growing library of plant disease predictive models. Additional Resources https://www.nature.com/articles/s41598-026-46975-z#Sec14 https://journals.ashs.org/view/journals/horttech/27/5/article-p710.xml https://cropprotectionnetwork.org/news/new-crop-risk-tool-enhances-disease-management-decisions Time Stamps 00:00 Understanding Machine Learning Models 03:23 Choosing the Right Model for the Project 06:13 Metrics for Model Evaluation 08:48 Challenges in Data Collection and Standardization 11:38 Insights on Frog Eye Leaf Spot Modeling 13:44 Future Directions and Improvements 17:40 Understanding Weather Data's Role in Disease Modeling 19:42 Data Collection and Analysis for Disease Severity 21:29 Introduction to Decision Support Systems (DSS) 22:27 The Importance of Decision Support in Agriculture 24:09 Future of Predictive Modeling and Decision Support Systems 28:44 The Role of Farmers in Utilizing Predictive Models 32:14 Economic Benefits of Decision Support Systems 34:29 Elevator Pitch: Explaining Predictive Modeling to the Public 37:58 outro with logo.mp4 Zaworski, E. (Host) and González-Acuña, J. (Interviewee). S5:E8 (Podcast). Frog Eye-PM: Predictive Modeling Part 2. 5/20/2026. In I See Dead Plants. Crop Protection Network. Transcript
Chris Wright is joined by:Communications Director for Progressive International, former advisor to Jeremy Corbyn, and author of ‘Our Bloc: How We Win' James SchneiderLabour Member of the London Assembly for Merton and Wandsworth since 2016, Leonie CooperHighly acclaimed writer, journalist, and broadcaster Christina Patterson Jean-Monnet Professor of European Integration at the National University of Ireland Maynooth, John O'Brennan Chris asks the panel whether the current political saga whereby Starmer's leadership is being challenged is a result of external conditions such as a right-wing media, or his own doing. In addition they discuss the lack of a program of wealth distribution, Starmer & Labour's political ‘own goals' since taking office, and the importance of communication. As the conversation develops focus turns to Andy Burnham and the significance of him going for the Labour leadership.Chapters00:00 The Political Landscape in the UK04:54 Challenges of Modern Governance09:27 Inequality and Economic Instability14:20 The Role of Communication in Politics19:07 Labour Party's Positioning and Strategy23:54 Global Issues and Domestic Politics28:16 Future Directions for the Labour Party34:29 Local Initiatives and Regional Politics37:49 The Brexit Dilemma39:59 Emotional Politics and Public Sentiment47:27 Inequality and Political Choices53:29 The Makerfield By-Election: A Crucial Battle01:04:21 Future of Labour Leadership'I Hit The Nail Right On The Head' by Billy Bremner. © Fridens liljor/Micke Finell.Rock around the clock productions AB.www.rockaroundtheclock.co This episode was produced by Sound SapienSoundsapien.com
Cut through the hype of Multi-Cancer Early Detection (MCED) tests and learn how to counsel patients on the real-world utility, false-positive risks, and the "stage shift" debate of these emerging blood assays. We are joined by world-renowned oncologist Dr. Margaret Tempero,UCSF Cancer Early Detection and Interception, to discuss whether these tests are truly ready for clinical prime time.Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMEShow Segments 00:00 Introduction 01:57 Current Cancer Screening Programs 06:05 Emerging Blood-Based Cancer Tests 11:55 Test Characteristics and Limitations 18:05 Practical Considerations for Patients 25:33 Direct-to-Consumer Testing/Whole Body MRIs 36:46 Navigating Positive Test Results 45:10 Anxiety and Patient Education 47:08 Future Directions in Cancer Screening Outro Credits Producer, Writer, Show Notes, Infographic, Cover Art: Molly Heublein MD Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP Reviewer: Sai S Achi MD,MBA,FACP Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Margaret Tempero, MD DisclosuresDr. Tempero reports the following financial relationships: Grail (research support), Global Bio Access Fund (Advisor), Bristol Myers Squibb (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Astra Zeneca (Membership on Advisory Committees or Review Panels, Board Membership, etc), Immunovia (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Merck (advisory committee), Renovo Rx (advisory committee), Urogen (Advisor). Financial relationships have not ended. The Curbsiders report no relevant financial disclosures. Sponsor: FIGS Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX. Sponsor: FreedTry Freed Front Desk free for 7 days at getfreed.ai/front-desk.Sponsor: Quince Go to Quince.com/curb for free shipping on your order and 365-day returns. Now available in Canada, too.
“The Transmitter is trying to cover the whole waterfront…”Kristin Ozelli is the Executive Editor of The Transmitter, a neuroscience publication supported by the Simons Foundation that launched in 2023. In this conversation, Peter and Kristin explore what makes The Transmitter tick. At its heart, the publication is driven by a conviction that neuroscience is most powerful when its many scales, modalities, and subfields are in conversation with each other, and that good science journalism can provide the intellectual scaffolding to make that happen. They discuss the editorial process behind the scenes, from morning story meetings and house style guides to multiple rounds of editing, and how scientist-written essays are helping fill the void left by the decline of science Twitter. The conversation also touches on The Transmitter's ambitious State of Neuroscience mapping project, the ongoing tension between a fragmenting field and the hunger for greater integration, and what it means to portray science as a genuinely human endeavor. They close with thoughts on AI in science writing, exciting new tools and resources coming to the site, and how publications like The Transmitter might help rebuild trust between scientists and a skeptical public.We hope you enjoy this episode!Chapters:00:00 - Introduction to the Transmitter and Its Mission05:49 - Kristin Ozelli's Journey to Neuroscience Journalism08:29 - The Transmitter's History and Evolution11:03 - Finding the Sweet Spot in Neuroscience Communication16:19 - Mapping Neuroscience: The State of Neuroscience Project23:22 - Engaging the OHBM Community and Beyond30:07 - The Evolution of Scientific Communication33:45 - Public Perception of Science40:22 - Future Directions for Transmitter47:15 - The Role of AI in JournalismResources:14:20 - The State of Neuroscience https://www.thetransmitter.org/state-of-neuroscience-report-2025/Episode producers:Karthik Sama, Xuqian Michelle Li
Dr. Kentaro Fujita, PhD, is a professor of psychology at The Ohio State University and an expert in the science of self-control and motivation. We discuss the best tools for developing strong self-control: to do more of what you aspire to and cease doing things you would like to avoid. We discuss why you need more than one form of willpower to achieve sustained motivation and overcome procrastination. Dr. Fujita also clarifies the data on the 2-marshmallow test, delayed gratification and intrinsic vs. extrinsic motivation. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Kentaro Fujita (00:03:08) Marshmallow Tests, Self-Control; Adult Modeling (00:08:24) Criticism of Marshmallow Tests, Learning Self-Control (00:15:08) Sponsors: David & Lingo (00:17:34) Movement & Motivation (00:21:42) Doing Hard Things; Exhaustion & Depletion Effect (00:29:02) Willpower vs Self-Control, Improving Self-Control (00:34:27) Aspiration or Fear for Motivation, Long- vs Short-Term Outcomes (00:40:55) Self-Control Toolkit, Tool: Failure & Exploration (00:46:44) Sponsor: AG1 (00:48:28) Motivation Warm-Up?, Tools: Mindset; Motivation Orientation (00:57:30) Imperfect Conditions, Self-Control Conflicts, Tool: Why vs How (01:05:25) Tool: "Whys" & Motivation Goals (01:11:26) Competition, Tool: Motivation Types (01:17:13) Sponsor: LMNT (01:18:33) Abstinence vs Moderation, Consistency vs Rigidity (01:27:48) Burnout; "Invisible" Goals, Single Goal & Trade-Offs (01:35:17) Intrinsic Motivation for Sustained Goals (01:40:16) Sponsor: Function (01:41:53) Meaning in Simple Tasks, Ikigai (01:49:03) Self-Control Failure, Tools: Distancing, 3rd Person & Heros (01:55:04) Words as Motivation, Visualization, Social Validation (02:03:51) Music, Anchors, Nostalgia (02:06:46) Intrinsic vs Extrinsic Motivation, Job & Salary (02:14:11) Mindfulness & Taking Breaks, Wabi-Sabi & Imperfection, Ikigai (02:20:56) Future Directions (02:25:19) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
You've probably spotted those little circles of your friends' faces popping up on Facebook Reels. They look simple enough, but building them was a proper engineering challenge. In this episode, Pascal chats to Joseph and Subasree about Friend Bubbles, a feature that surfaces which of your close friends have been watching and reacting to the same Reels as you. We get into the details of how prefetching keeps things snappy without wrecking scroll performance, why the team's ML model had to move from survey-based friend rankings to real-time interaction signals, and the surprising discovery that showing fewer bubbles actually made the whole feature click. If you've ever underestimated a "simple" feature, this one's for you. Got feedback? Send it to us on Threads (https://threads.net/@metatechpod), Instagram (https://instagram.com/metatechpod) and don't forget to follow our host Pascal (https://mastodon.social/@passy, https://threads.net/@passy_). Fancy working with us? Check out https://www.metacareers.com/. Links https://engineering.fb.com/2026/03/18/ml-applications/friend-bubbles-enhancing-social-discovery-on-facebook-reels/ https://engineering.fb.com/2026/04/21/ml-applications/modernizing-the-facebook-groups-search-to-unlock-the-power-of-community-knowledge/ Timestamps Intro 0:06 Meet the Engineers: Backgrounds and Roles 1:53 Goals and Aspirations in Video Recommendations 4:20 The Origin of Friend Bubbles 4:41 Defining Success: Metrics and User Experience 5:40 Client-Side Constraints and Challenges 6:57 Feature Description: What Are Friend Bubbles? 8:31 Initial Challenges and Performance Issues 9:29 Architectural Changes for Performance 11:34 Impact of Performance on User Experience 15:14 Addressing Client-Side Challenges 16:58 Model Development: From Surveys to Interactions 20:07 Evolving the Model: Real-Time Data and User Interactions 23:35 Exploring Model Training and Performance 24:58 Feedback Loops and User Engagement 25:56 The Role of AI in Development 29:49 Collaboration Across Teams 32:17 Future Directions for Friend Bubbles 34:02 Safe Rollout Strategies for Features 35:22 Outro 37:31 Bloopers 38:27
Stay informed on current events, visit www.NaturalNews.com - Data Centers and Their Overbuilding (0:11) - Introduction to the Theory (2:05) - Global Data Center Build-Out (3:20) - Revenue Model and Financial Concerns (6:04) - The Role of AI and Simulation Theory (8:48) - Simulated Worlds and Digital Darwinism (17:41) - Practical Applications of Simulated Worlds (22:47) - The Simulation Hypothesis (32:52) - Theological and Philosophical Implications (50:42) - Conclusion and Future Directions (53:21) - Machine Settings and Crop Contamination (1:20:24) - Food Contamination and Industry Trends (1:25:42) - Global Food Scarcity and Quality Control (1:27:49) - Self-Reliance and Preparedness (1:33:16) - Impact of Middle East Conflict on Global Food Supply (1:36:04) - Economic and Energy Implications (1:58:35) - Preparation and Adaptation Strategies (2:08:53) - Potential Outcomes of Continued Conflict (2:12:41) - Call to Action and Final Thoughts (2:16:44) Watch more independent videos at http://www.brighteon.com/channel/hrreport ▶️ Support our mission by shopping at the Health Ranger Store - https://www.healthrangerstore.com ▶️ Check out exclusive deals and special offers at https://rangerdeals.com ▶️ Sign up for our newsletter to stay informed: https://www.naturalnews.com/Readerregistration.html Watch more exclusive videos here:
You have probably heard of the vagus nerve, and (whether you realize it or not) have been exposed to some of the concepts of Polyvagal Theory in yoga classes. In fact, we have discussed the theory in a previous episode of the podcast. In today's episode, host Rachel Land and Yoga Medicine Therapeutic Specialist Valerie Knopik, PhD, revisit Polyvagal Theory and explore the latest scientific debate it has generated. They break down the original framework, the newer criticisms, and the ways scientific ideas evolve over time. The conversation stays grounded in real-world teaching, especially around stress response, breath, and the role of relationships in helping people feel safe enough to practice. It is a thoughtful reminder that research can shift while the practical value of awareness, connection, and regulation remains central to yoga. "Science is never stagnant, and that's part of the beauty of science for me." — Valerie Knopik. — What You'll Learn: Vagus nerve roles in stress and relaxation response [3:24] Recent papers updating and challenging Polyvagal Theory (PVT) [4:41] The nature of the scientific method [7:12] Defining PVT [10:37] Summarizing the current controversy: over-simplification of dorsal vs ventral vagus [25:29] Other points of contention: dorsal vagal and trauma response, heart rate variability as a measure of vagal tone, clinical over-use [31:41] Relevance to yoga teaching and practice [37:11] The "science of safety" in yoga: Yoga Medicine Mental Health & Wellness Teacher Training [44:00] — Links Mentioned: Watch this episode on YouTube Mental Health & Wellness Yoga Teacher Training Yoga Medicine Podcast Research Roundup: Updates on Polyvagal Theory Porges SW. Polyvagal Theory: Current Status, Clinical Applications, and Future Directions. Clin Neuropsychiatry. 2025 Jun;22(3):169-184. doi: 10.36131/cnfioritieditore20250301. PMID: 40735382; PMCID: PMC12302812 Grossman P et al. Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Clin. Neuropsychiatry, 22(3), 169-184. Clin Neuropsychiatry. 2026 Feb;23(1):100-112. doi: 10.36131/cnfioritieditore20260110. PMID: 41768017; PMCID: PMC12937499 Yoga Medicine Podcast Episodes: Epigenetics, Mental Health & Yoga The Neuroscience of Resilience Interoception Research & Yoga Connect with Valerie Knopik, PhD: Facebook | Instagram | X | YMO Teacher Learn More: Find the full show notes at YogaMedicine.com/podcast-166. Learn more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts or wherever you listen to podcasts.
Have you ever walked through a city and felt, almost physically, that it was too much or not enough? That feeling has a name. Alex Yuen, architect, urbanist, and host of Most Podern, calls it density appetite and it might be the most fundamental idea in urbanism that no one is talking about. From the way Tokyo reinvents itself decade after decade to the way San Francisco has quietly frozen itself in place, the cities we live in are a direct reflection of how much growth we're actually willing to stomach. This conversation unpacks how density works not just as a planning metric but as a deeply personal, political, and cultural force, one that shapes your rent, your commute, your neighborhood, and your quality of life. Whether you're a lifelong city dweller or someone who just moved out to the suburbs, you probably already have a density appetite. You just didn't know what to call it.Read the original essay that sparked the conversation on Alex's Substack, Dust to Density: https://www.dusttodensity.com/p/density-appetiteSubscribe to Most Podern on:Spotify - https://open.spotify.com/show/3zYvX2lRZOpHcZW41WGVrpApple Podcasts - https://podcasts.apple.com/us/podcast/most-podern-podcast/id1725756164Youtube - https://www.youtube.com/@MostPodernInstagram - https://www.instagram.com/most.podernLinkedIn - https://www.linkedin.com/company/most-podernKeywordsdensity, urban density, density appetite, city planning, housing policy, housing crisis, urbanism, urban design, NIMBY, NIMBYism, urban growth, zoning, ADU, accessory dwelling units, urban metabolism, Tokyo housing, San Francisco housing, Los Angeles housing, built environment, walkability, public transit, housing affordability, mixed-use development, floor area ratio, FAR, population density, city development, city life, suburb vs city, urban planning podcast, urban cultureChapters00:00 Understanding Density Appetite03:02 Density in Urban Environments07:07 Comparing Density Appetite Across Regions10:12 California's Evolving Density Policies11:34 Metabolism of Urban Density14:48 Challenges of Density in American Cities18:27 Cultural Influences on Density Appetite19:33 Cultural Perspectives on Public Spaces21:24 Understanding Urban Density and Infrastructure23:38 The Complexity of Density Appetite25:39 Leadership in Urban Planning27:36 The Role of Architects in Politics28:24 Personal Experiences with Density32:14 Future Directions in Urban Density Discussions
What if the real risk of AI in schools isn't that it cheats - it's that it quietly switches off the parts of our brains we need most? In this episode, we sit down with Dr. Rob Wessman, VP of Ethics and Safety at School AI, to dig into one of the most important questions in education right now: are we building AI tools that develop young people, or tools that do the developing for them? With a background as a high school English teacher, school administrator, and Harvard EdLD graduate, Rob brings a genuinely human lens to the world of edtech and a compelling case for why getting this right matters more than getting it fast. We cover:- The MIT study that showed students struggling to think for themselves after outsourcing their essays to AI- Why School AI's research shows a 28% boost in higher-order reasoning - and how design makes the difference- The deskilling risk hiding in plain sight (and what endoscopy doctors can teach us about it)- Why banning AI in schools may be more dangerous than letting students use it unsupervised- The "agency with guardrails" challenge: how do you build tools that protect without limiting?- What Singapore's education ministry gets right — and why we should be paying attention- Why School AI removed their cute avatar and what it says about human-AI honesty Whether you're a school leader trying to make sense of AI policy, an educator worried about what students are losing, or just someone who wants the tech to actually serve learning, we think you'll like this one! Chapters0:00 Introductions02:35 Rob Wessman's Background in Education05:16 Rob's Role at School AI and Its Mission08:45 Designing AI to Promote Critical Thinking12:05 Safety Guardrails and Ethical Use of AI14:03 MIT Study on De-skilling and AI Risks17:00 Boosting Higher-Order Reasoning with AI20:27 Supporting Teachers and Human Connection24:09 Legislation and Societal Concerns about AI28:15 Educating About AI and Its Risks32:47 Future Directions and Responsible AI Design40:37 What Remains Human in Education?43:31 Closing Remarks Read the research around SchoolAI and Critical ThinkingFind out more about SchoolAICheck out all things Edufuturists
In episode 156 of The Side Hustle Experiment Podcast John (https://www.instagram.com/sidehustleexperiment/ ) and Drew (https://www.instagram.com/realdrewd/) talk with Miles Longstreth (https://www.instagram.com/mileslongstrethinfo)Miles shares his journey from Amazon FBA to coaching, leveraging AI tools, and building a sustainable online business. Discover his strategies for content creation, community building, and navigating market saturation.Don't forget to Like, Subscribe, and hit the bell so you don't miss future episodes with top entrepreneurs and creators.Chapters00:00 Introduction and Background02:41 Transition to Coaching and Consulting05:30 Utilizing AI in Content Creation08:39 YouTube Strategy for Coaching Success11:36 Adapting to Changes in the Amazon Market14:27 Building a Community for Coaching17:00 Lessons Learned from Coaching Experience19:56 The Importance of Networking22:59 Starting Offers and Unique Selling Propositions25:38 Documenting the Journey28:34 The Evolution of Social Media and Marketing31:29 Authenticity in Coaching and Marketing36:04 Understanding Client Expectations and Realities38:14 The Role of Ads in Business Strategy39:17 Building an Organic Audience42:03 The Importance of Patience in Content Creation44:08 The Long-Term Value of Consistency45:17 Navigating Coaching and Client Relationships48:08 The Challenge of One-on-One Coaching50:40 Lead Magnets and Community Building52:32 Saturation in the Market53:47 Understanding Market Saturation and Personal Action58:22 Leveraging AI in Business01:03:59 Wrapping Up and Future Directions#makemoneyonline #sidehustleexperimentpodcast #sidehustles Follow us on Instagram: https://www.instagram.com/sidehustleexperimentpodcast/ Listen on your favorite podcast platformYoutube: https://bit.ly/3HHklFOSpotify: https://spoti.fi/48RRKcPApple: https://apple.co/4bmaFOk Check out Drew's StuffInstagram: https://www.instagram.com/realdrewdTwitter: https://twitter.com/DrewFBACheck out John's StuffInstagram: https://www.instagram.com/sidehustleexperiment/Twitter: https://twitter.com/SideHustleExp FREE ResourcesFREE Guide: How to Make Money Reviewing Products https://bit.ly/3HIGFSP
Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Oral SERDs for Breast Cancer | Faculty Presentation 2: Future Directions in the Use of Oral SERDs for HR-Positive, HER2-Negative BC — Erica Mayer, MD, MPH, FASCO CME information and select publications
In Episode 4 of The Research Rundown, hosts Paul Buchheit (Head Athletic Trainer, Phillies) and Joe Rauch (Assistant Athletic Trainer, Phillies) are joined by Brad Pearson (VP of Sports Medicine, Red Sox) to break down the relationship between training load and injury risk. Using the paper “Training Load and Injury: Causal Pathways and Future Directions,” the group explores what the research actually says about causality, common misconceptions, and how athletic trainers can apply these insights in real-world settings.View the full paper here: https://pubmed.ncbi.nlm.nih.gov/33400216/For more information about PBATS and athletic training, visit pbats.com.
Gupta examines disparities in food allergy and asthma outcomes, highlighting barriers to care and the role of policy, research, and innovation in improving health equity. Timestamps: 01:00 – Racial and socioeconomic barriers 03:37 – Collaborations to reduce disparities 05:05 – Emerging therapies 10:08 – Future care
Do you know how to apply best practices for HER2 testing and identify patients who may benefit from targeted therapies? Join us to learn more! Credit available for this activity expires: 4/28/27 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/advancing-care-her2-mutated-nsclc-evidence-diagnostics-and-2026a1000d6g?ecd=bdc_podcast_libsyn_mscpedu
"AI is about to create the biggest divide humanity has ever seen."That's the warning Chinn, founder of dConstruct, dropped on Bricks & Bytes.He sold his startup to Autodesk. Built Singapore's Smart Nation. Now he's putting AI robots on construction sites that see every flaw in millimetres.Tune in to find out about:✅ Why perfect site data is bankrupting construction projects✅ The new AI currency that will split the industry in two✅ Why 90% of construction robots are a lie✅ The data move every construction leader has 10 years to makeWatch now on Spotify and YouTube
The Animal Welfare Department (AWD) at Rethink Priorities supports high-impact strategies to help animals, especially where suffering is vast and largely neglected. Therefore, one of our focus areas is wild animal welfare (WAW), where uncertainty about tractability makes identifying cost-effective interventions particularly challenging. While much of the current WAW work rightly focuses on academic field-building (see Elmore & McAuliffe, 2024), it is worth determining whether there are viable, near-term interventions that are already available or close to implementation. With this goal in mind, we have developed the Wild Animal Welfare Intervention Database (WAWID). This project evaluates an array of interventions that may be promising for improving WAW in the (relatively) near term, evaluating them relative to criteria of interest to funders, advocates, researchers, and potential implementers across the WAW space. The WAWID is available here: Wild Animal Welfare Intervention Database The landing page includes a full list of the interventions and evaluation criteria. This report explains how we developed the WAWID, what we think you can learn from it, and suggest some future directions for this work (conditional on funding). A future report will provide some descriptive statistics. How we developed the WAWID We launched this project in [...] ---Outline:(01:34) How we developed the WAWID(08:14) Initial observations(13:13) Limitations(15:20) Future Directions(16:48) Acknowledgements --- First published: March 25th, 2026 Source: https://forum.effectivealtruism.org/posts/pEbiEmeu2agEHJgyu/a-database-of-near-term-interventions-for-wild-animals --- Narrated by TYPE III AUDIO. ---Images from the article:Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
Welcome back to another episode of Creatives Grab Coffee! In this episode, we are joined by Ed Rowe and Celia Hodgson from Tiny Studios. Tiny Studios is a B Corp certified production company based in London. They work across various sectors to produce impactful web and social content that truly shifts the needle. Today, we dive into their journey from freelance life to agency ownership, the importance of building a healthy on-set culture, and what it's like to navigate an agency acquisition while staying true to your core values. Chapters 00:00 Introduction to Tiny Studios 07:00 The Journey from Freelancer to Company 13:56 Building a Team and Company Structure 19:57 Navigating Client Expectations and Budgeting 29:02 Lessons Learned and Future Aspirations 29:48 Building Through Word of Mouth 34:25 Navigating Gender in the Industry 37:47 Creating Inclusive Spaces for Filmmakers 41:06 Challenging the Burnout Mentality 49:29 Understanding Client Value Propositions 53:42 The Journey of Acquisition and Integration 01:04:37 Building a Pipeline for Success 01:06:55 Navigating the Acquisition Process 01:09:59 The Value of B Corp Certification 01:16:00 Preparing for B Corp: A Guide for Businesses 01:21:04 The Importance of Documentation and Processes 01:25:01 Final Thoughts and Future Directions 01:30:02 Outro
Featuring perspectives from Dr Amir Fathi and Dr Eunice S Wang, including the following topics: Introduction: Overview — Biopharmacologic Considerations (0:00) Menin Inhibitor Monotherapy (21:51) Differentiation Syndrome (36:12) Menin Inhibitor Combination Approaches (45:15) Future Directions (49:59) PARADIGM — Randomized Phase II Trial (53:24) CME information and select publications
This isn't just another interview. I sat down with Dr. Stuart McGill to talk honestly about back pain, training, and all the stuff people get wrong online. We get into flexion, pain science, injuries, and how to actually train without messing yourself up long term. No fluff, no internet arguments, just a real conversation. If you train, deal with pain, or coach others, you'll get something from this. 00:00 – Introduction and Overview 03:11 – Addressing Criticisms and Flexion 10:46 – Epidemiology and Risk Assessment 14:04 – Core Endurance and Spine Hygiene 18:58 – Coaching and Performance Nuance 21:40 – Adaptation and Tissue Science 33:02 – Mechanisms of Disc Resolution 36:07 – Case Studies in Strength and MMA 44:49 – Refining the Assessment Process 50:25 – Neuroscience vs. Biomechanics 55:29 – Reintroducing Load and Progressive Training 01:00:37 – Future Directions and Closing https://chrisduffin.com/ Coaching, Peptides, Supplements, eBooks & Merch, Education, and my Free Community! A deeper dive on coaching, peptides, and regenerative amplification method at https://www.enhancedexecutive.com/
Järvinen-Seppo discusses how translational research is advancing understanding of early allergic disease, from maternal antibodies to global collaborations shaping the future of prevention and care. Timestamps: 00:57 – Research scope 03:49 – Maternal antibodies 07:34 – Integrating new evidence 09:17 – International coordination 10:37 – Emerging areas
In this episode, Scott and Wes sit down with Tim Neutkens and Jimmi Lai from the Next.js team to dig into the new Adapters API, what it takes to run Next.js across platforms like Cloudflare and Netlify, and how caching and infrastructure choices affect performance. They also go deep on TurboPack's internals, why Next.js doesn't run on Vite, and the evolution of bundling in the framework. Show Notes 00:00 Welcome to Syntax! 01:14 Introduction to Next.js and the Adapter Platform Next.js Across Platforms 02:23 The Adapters API: Features and Community Needs 04:46 Building and Testing the Adapters API 07:37 Infrastructure Requirements for Next.js Apps 11:38 Caching Strategies and Performance Optimization 13:29 The Role of Cache Components in Next.js 17:21 First Steps of Optimizations. 19:48 Blessed Adapters and Community Contributions 22:56 Future Directions and Runtime Support 25:05 Challenges with Different Runtimes and Debugging 26:45 Webpack vs. TurboPack: The Evolution of Next.js 29:45 Why Not Run on Vite? 32:47 Navigating Bundler Challenges 36:59 Building TurboPack: Lessons Learned 41:42 Incremental Compilation and Performance Episode with ByteDance's Zack Jackson 43:50 Framework Comparisons and Performance Metrics 46:42 Exploring Future Directions for TurboPack 49:44 TurboPack's Integration and API Development 52:50 Standardization in Bundler Tools 56:52 TurboPack's Adoption and User Experience 57:49 Sick Picks + Shameless Plugs Sick Picks Tim: Acquired Podcast Jimmy: Hydrangea Coffee Shameless Plugs Jimmy: nextjs-across-platforms Hit us up on Socials! Syntax: X Instagram Tiktok LinkedIn Threads Wes: X Instagram Tiktok LinkedIn Threads Scott: X Instagram Tiktok LinkedIn Threads Randy: X Instagram YouTube Threads
In this episode, Dr Matthew Gubens and Dr Helena Yu discuss the evolving role of TROP2-directed therapies in non-small-cell lung cancer, with a focus on how antibody–drug conjugates (ADCs) fit into current treatment strategies, including The mechanism of action and clinical trial outcomes of TROP2-directed ADCs like datopotamab deruxtecan and sacituzumab tirumotecan Use of these therapies in EGFR-mutant disease and how they fit into a changing treatment landscape Practical advice on associated adverse events and additional considerations, A look at future directions on the horizon, such as first-line studies and predictive biomarkers Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Presenters: Matthew Gubens, MD, MS, FASCO Medical Director, Thoracic Medical Oncology University of California, San Francisco San Francisco, California Helena Yu, MD Professor of Medicine Thoracic Oncology Service Memorial Sloan Kettering Cancer Center New York, New York Link to full program:https://bit.ly/41vAnfH Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
EPISODE 155CRUCIAL ISSUES AND FUTURE DIRECTIONS IN AUTISM AND NEURODIVERSITY:A DISCUSSION WITH AUTISTIC PARENT-PROFESSIONAL SARA BRADFORD (AKA SJ CHILDS)Sarah Bradford (aka SJ Childs) is a parent professional, who has a wide range of contact with the autistic and neurodivergent community through her more than 600 interviews in her podcast and annual summits. Barry and Dave discuss a range of issues with her to tap into her knowledge-base and the ability she has to have a thumb on the pulse of areas of need, as well as future directions in supporting the community she is immersed in as a parent and professional.Learn more on our website See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, Chris goes nuts in his intro and together with Graeme and Neil delve into the latest FUT promo, Trophy Titans. They analyze new cards, play styles, and the state of the game. They also discuss content creator trends, game modes, and potential future updates, providing insights for the FUT fans.Chapters00:00 Introduction to the Clash of Content Titans02:07 Weekly Gameplay Experiences06:59 Trophy Titans Promo Overview15:03 Heroes and Icons Analysis24:57 Evaluating the Promo Scores28:02 Evaluating Striker Play Styles31:52 The State of the Game: Content Creator Perspectives38:52 EA's Challenges and Community Feedback43:48 Future Directions for FUT Game ModesCheck out our socials:X: https://twitter.com/futinreviewInstagram: https://instragram.com/futinreviewTikTok: https://www.tiktok.com/@futinreviewpodcastQuestions: futinreview@gmail.comhttps://youtube.com/futinreviewhttps://www.futinreview.com https://patreon.com/futinreview
Stay informed on current events, visit www.NaturalNews.com - Weekend Warrior vs. Weekday Trump (0:12) - Details of the Failed Uranium Rescue Mission (2:28) - Analysis of the Failed Mission and Its Implications (11:02) - Trump's Manipulation of Markets and Geopolitical Realities (17:35) - The Decline of Western Civilization (17:52) - AI Advancements and Their Impact (27:45) - Introduction of Guests and Their Roles (39:23) - Explanation of the Technology and Its Claims (53:49) - Challenges and Skepticism of the Technology (1:16:20) - Practical Applications and Future Directions (1:28:07) - Restoration of Ideal Climatic Conditions (1:28:24) - Testing and Demonstration Proposals (1:37:29) - Observations and Phenomena Around the Device (1:39:37) - Impact on Plant Growth and Soil Health (1:42:41) - Alternatives to Chemical Agriculture (1:49:15) - Final Thoughts and Future Plans (1:52:48) - After Party Discussion and Additional Insights (2:16:56) - Promotion of Decentralized Agriculture (2:17:17) - Conclusion and Next Steps (2:17:51) Watch more independent videos at http://www.brighteon.com/channel/hrreport ▶️ Support our mission by shopping at the Health Ranger Store - https://www.healthrangerstore.com ▶️ Check out exclusive deals and special offers at https://rangerdeals.com ▶️ Sign up for our newsletter to stay informed: https://www.naturalnews.com/Readerregistration.html Watch more exclusive videos here:
A look back on the TopMedTalk coverage of last year's incredible ANESTHESIOLOGY® 2025 in San Antonio, Texas, USA. This is part one of a two part piece. Featuring clips and discussion from the following podcasts: Pediatric Airway Management Advances: Insights from Annery Garcia-Marcinkiewicz https://topmedtalk.libsyn.com/pediatric-airway-management-advances-insights-from-annery-garcia-marcinkiewicz The Center for Anesthesia Workforce Studies at ANESTHESIOLOGY® 2025 https://topmedtalk.libsyn.com/the-center-for-anesthesia-workforce-studies-at-the-asa-2025 Understanding Anesthesia Information Management Systems with Dr. David Kennedy https://topmedtalk.libsyn.com/understanding-anesthesia-information-management-systems-with-dr-david-kennedy Transforming Pain Medicine: An Insight into the Pain Medicine Coalition https://topmedtalk.libsyn.com/transforming-pain-medicine-an-insight-into-the-pain-medicine-coalition Clinical Readiness and Training Affiliation in Army Anesthesiology https://topmedtalk.libsyn.com/clinical-readiness-and-training-affiliation-in-army-anesthesiology Navigating Governance in Anesthesiology Groups: Insights from ANESTHESIOLOGY® 2025 https://topmedtalk.libsyn.com/navigating-governance-in-anesthesiology-groups-insights-from-asa-2025 Anesthesiology Economics: Current Trends and Future Directions https://topmedtalk.libsyn.com/anesthesiology-economics-current-trends-and-future-directions Insights on the Future of Anesthesia Quality Improvement with AQI https://topmedtalk.libsyn.com/insights-on-the-future-of-anesthesia-quality-improvement-with-aqi Insights from ANESTHESIOLOGY® 2025: New Guidelines for Anesthesiology in Older Adults https://topmedtalk.libsyn.com/insights-from-anesthesiology-2025-new-guidelines-for-anesthesiology-in-older-adults Nitrous Oxide as a Treatment for Severe Depression: Insights from ANESTHESIOLOGY® 2025 https://topmedtalk.libsyn.com/nitrous-oxide-as-a-treatment-for-severe-depression-insights-from-anesthesiology-2025 -- Join us at Evidence Based Perioperative Medicine (EBPOM) World Congress 2026 in London. Be part of a global conversation as clinicians from around the world gather between 7-9th July at the British Library in London. Three days of evidence-based perioperative medicine, global insights, and expert debate—featuring speakers including Michael Marmot and Ken Rockwood. Register here - https://ebpom.org/product/ebpom-world-congress-2026/
This episode features a lively discussion on recent travel mishaps, opinions on CrossFit programming, and the importance of enjoying fitness without overcomplication. The hosts share personal stories, critique current competition formats, and explore the value of fun and simplicity in fitness routines. Topics Travel chaos and airport stories Critique of CrossFit quarterfinal programming The importance of fun and exploration in fitness Discussion on competition standards and innovation The role of community and motivation in fitness Themes The Realities of Travel Nightmares and Airport Adventures Critiquing CrossFit Quarterfinals: Innovation or Stagnation? Sound Bites "That whole thing was a nightmare." "Shake Shack is overhyped." "The workouts are too bland." Chapters 00:00 Airport Adventures: Tyler's Travel Tales 12:30 Quarterfinal Workouts: A Critical Review 20:06 Standards in Competitive Sports 23:36 The Evolution of Competition Formats 28:36 The Need for a Unified Competitive Landscape 34:38 Rediscovering the Joy of Fitness 39:17 Closing Thoughts and Future Directions
In this episode, Dr. Brendan McCarthy—Chief Medical Officer at Protea Medical Center—dives into one of the most misunderstood topics in health: Why does it feel like you can't stick to a diet… even when you're trying your best? This isn't about willpower. It's not a character flaw. And it's not your fault. Dr. McCarthy breaks down the biology behind stress, cravings, and weight gain—explaining how chronic stress rewires your brain, alters decision-making, and drives you toward hyper-palatable, ultra-processed foods. YouTube citations : 1. Arnsten, Amy F. T. “Stress Weakens Prefrontal Networks: Molecular Insults to Higher Cognition.” Nature Neuroscience, vol. 18, no. 10, 2015, pp. 1376–1385. Why it is here: Foundational paper for the claim that uncontrollable stress increases catecholamine signaling in the prefrontal cortex and degrades higher-order control, working memory, and inhibition. This is one of the strongest anchors for the idea that stress makes the pause smaller. 2. Schwabe, Lars, et al. “Concurrent Glucocorticoid and Noradrenergic Activity Shifts Instrumental Behavior from Goal-Directed to Habitual Control.” Journal of Neuroscience, vol. 30, no. 24, 2010, pp. 8190–8196. Why it is here: One of the most important papers for your “click-boom” model. It shows that stress chemistry can bias behavior away from goal-directed control and toward habit-like responding. That is not a morality argument. It is control architecture. 3. Plessow, Franziska, et al. “The Stressed Prefrontal Cortex and Goal-Directed Behaviour: Acute Psychosocial Stress Impairs the Flexible Implementation of Task Goals.” Experimental Brain Research, vol. 216, no. 3, 2012, pp. 397–408. Why it is here: Strong support for the claim that acute psychosocial stress impairs flexible goal implementation. Useful when you want to say that under stress, the person may still know what matters but have reduced access to that guidance in the moment. 4. Maier, Silvia U., et al. “Acute Stress Impairs Self-Control in Goal-Directed Choice by Altering Multiple Functional Connections within the Brain's Decision Circuits.” Neuron, vol. 87, no. 3, 2015, pp. 621–631. Why it is here: Excellent for the food-choice angle. This paper supports the idea that stress increases the weight of immediately rewarding attributes and reduces self-control. In your language, the cue gets louder and the future gets quieter. 5. Epel, Elissa, et al. “Stress May Add Bite to Appetite in Women: A Laboratory Study of Stress-Induced Cortisol and Eating Behavior.” Psychoneuroendocrinology, vol. 26, no. 1, 2001, pp. 37–49. Why it is here: Classic paper, directly in women, directly in Psychoneuroendocrinology. Strong support for linking stress physiology, cortisol reactivity, and post-stress eating behavior. 6. Giddens, Emily E., et al. “The Influence of Stress on the Neural Underpinnings of Disinhibited Eating: A Systematic Review and Future Directions for Research.” Reviews in Endocrine and Metabolic Disorders, 2023. Why it is here: A modern review tying stress to food-related reward sensitivity, interoception, and cognitive control in disinhibited eating. Good bridge reference for the overall brain-food-stress model. 7. Lyu, Z., et al. “Acute Stressors Reduce Neural Inhibition to Food Cues and Increase Eating Among Binge Eating Disorder Symptomatic Women.” Frontiers in Behavioral Neuroscience, 2016. Why it is here: Helpful for the specific claim that acute stress can reduce inhibitory neural responsiveness to food cues and increase eating in vulnerable women. Strong fit for the cue-reactivity piece. Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.
In this episode of Talk Commerce, Christina Augustine, COO of Bloomreach, discusses the transformative role of conversational agents in e-commerce, the importance of personalization, and the future of websites in the age of AI. She emphasizes the need for businesses to adapt to changing consumer behaviors and the significance of integrating AI while maintaining human oversight. The conversation also touches on the evolving landscape of composable platforms and the economic considerations affecting e-commerce today.TakeawaysChristina Augustine is the COO at Bloomreach, focusing on conversational agents and AI.Conversational agents enhance customer experiences by personalizing interactions.Personalization in e-commerce has evolved from being creepy to expected.AI can help automate shopping experiences but requires human oversight.Websites will not disappear; they will coexist with AI-driven platforms.Understanding consumer behavior is crucial for effective marketing strategies.SEO is impacted by AI-generated content, requiring new approaches.Composable platforms are becoming more flexible and user-friendly.Economic scrutiny is influencing consumer spending habits.Businesses should leverage customer insights to improve their offerings.Connect with Christy on linkedin: https://www.linkedin.com/in/christinaaugustine/ Or learn more about Bloomreach here: https://www.linkedin.com/company/bloomreach/Chapters00:00 Introduction to Bloomreach and Christina Augustine02:21 Understanding Conversational Agents in Commerce06:52 The Future of Agentic Commerce09:20 The Role of Websites in E-commerce11:39 Advancements in Personalization with AI14:32 Ensuring Human Oversight in AI Interactions16:11 Navigating Content in an AI-Driven World19:11 The Evolution of Composable Platforms21:56 E-commerce Outlook Amid Economic Changes23:43 Upselling and Cross-Selling Strategies25:01 Learning from Customer Interactions27:04 Closing Thoughts and Future Directions
In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Andrea Maier, Professor in Medicine and Director of the NUS Academy for Healthy Longevity at the National University of Singapore's School of Medicine. They explore what the evidence shows on supplements, and why “test, then treat” beats guesswork.Andrea unpacks a review of over 5 million people: multivitamins may support memory and lower systolic blood pressure in some older or at-risk groups, but offer little for healthy adults. She also reports lab audits of Nicotinamide Mononucleotide (NMN) and urolithin A, in which many products fell short of the label claims.She then sorts buzzworthy compounds like alpha-ketoglutarate, spermidine, curcumin, and melatonin by mechanism, trial quality, and fit. Her rule stays simple: measure what you can, match the dose to the need, and track outcomes with walking speed, grip strength, steps, and wearable sleep data over time, not once. Guest-at-a-Glance
This conversation focuses on the implementation of a cold blood protocol for military training, emphasizing the importance of whole blood transfusions in preventing deaths from hemorrhagic shock. The discussion covers the logistics of blood availability, the challenges of storage and transportation, and the establishment of a pilot program for blood donation. The speakers highlight the collaboration with blood banks and the regulatory hurdles faced, while also outlining future directions for expanding the program to enhance medical support during training events.TakeawaysHemorrhage is the leading cause of preventable death on the battlefield.Whole blood is recognized as the superior resuscitation fluid.Logistics and availability of blood during training are critical issues.Cold blood storage can be effectively implemented in training environments.A pilot program for blood donation has been established to support training needs.Collaboration with blood banks is essential for successful blood storage and use.Regulatory challenges complicate blood storage and transportation.Training medics to use cold stored blood is a priority.Future expansion of the program is necessary to meet training demands.Increased knowledge of blood protocols enhances medic preparedness.Chapters00:00 Introduction to Cold Blood Protocol03:02 Understanding Hemorrhagic Shock and Blood Transfusion06:07 Logistics of Blood Availability in Training08:55 Implementing Cold Blood Storage in Training Environments12:11 Pilot Program for Blood Donation and Storage14:50 Collaboration with Blood Banks and Regulatory Challenges18:14 Future Directions and Program Expansion20:58 Conclusion and Key TakeawaysFor more content, go to www.prolongedfieldcare.orgConsider supporting us: patreon.com/ProlongedFieldCareCollective or www.lobocoffeeco.com/product-page/prolonged-field-care
Below-the-knee (BTK) arterial disease remains one of the more challenging areas in vascular care, particularly in patients with chronic limb-threatening ischemia (CLTI), where heavy calcification complicates endovascular treatment. As new calcium-modifying technologies emerge, an important question remains: what evidence supports their use in BTK interventions? In this episode of BackTable Vascular & Interventional, host Dr. Sabeen Dhand speaks with vascular surgeon Dr. Paul Foley of Doylestown Health about the Disrupt BTK II clinical trial from Shockwave Medical, which evaluates the performance of peripheral intravascular lithotripsy (IVL) in heavily calcified BTK disease. --- This podcast is supported by: Shockwave Medicalhttps://shockwavemedical.com/ --- SYNPOSIS Dr. Foley begins by outlining his training and the evolution of his vascular surgery practice, setting the stage for a broader discussion on how BTK interventions have changed over the past decade. The conversation explores shifts in access strategies, procedural approaches, and the unique characteristics of calcification encountered in CLTI. Because BTK calcium differs from calcification seen elsewhere in the peripheral vasculature, imaging and device selection play a particularly important role when planning IVL-based therapies. Dr. Foley reviews the design and outcomes of the Disrupt BTK II trial, where devices such as the Shockwave M5+ and S4 catheters were used to modify calcified plaque, demonstrating encouraging safety and performance signals. The discussion then turns to emerging technologies, including Shockwave's Javelin catheter, designed to deliver focused pressure waves to fracture dense calcium within peripheral arteries. Dr. Foley describes how the device fits into BTK workflows, including technique considerations and its use alongside adjunctive therapies such as balloon angioplasty. The episode also addresses the ongoing skepticism surrounding IVL in BTK disease, emphasizing the need for careful patient selection, procedural precision, and continued multidisciplinary collaboration as the field works to refine treatment strategies and improve outcomes for patients with peripheral artery disease (PAD). --- TIMESTAMPS 00:00 - Introduction08:20 - Evolution of Below-the-Knee Treatments11:10 - Differences in BTK Calcification13:13 - Imaging and Technology in BTK Interventions15:18 - Disrupt BTK II Trial Data and Results23:17 - Introduction to the Javelin Device26:39 - Technique Considerations with Javelin28:36 - Comparing Javelin and E831:17 - Future Directions for Lithotripsy Technology35:30 - Skepticism Around IVL in BTK Disease38:47 - Final Thoughts --- RESOURCES Disrupt BTK II Trialhttps://www.jvascsurg.org/article/S0741-5214(24)02063-9/fulltext
Stay informed on current events, visit www.NaturalNews.com - Introduction and Overview of Upcoming Reports (0:10) - Critique of Trump's State of the Union Speech (1:57) - Supreme Court Strikes Down Trump's Tariffs (5:32) - Economic Impact of Trump's Tariffs (34:30) - Trump's Economic Policies and Their Consequences (37:40) - The Role of AI in Job Replacement (38:00) - The Age of Ignorance is Over (51:23) - Interview with Garland Nixon (1:11:34) - International Political Tensions (1:18:08) - Impact of Potential War with Iran on American Politics (1:21:53) - War Weary Military and Instability (1:22:27) - Trump's Military Posturing and Credibility (1:24:46) - Risk of Loss of Credibility and Worst-Case Scenarios (1:27:47) - Impact of Huckabee's Remarks on Arab States (1:30:31) - Trump's Collapsing Support and Midterm Implications (1:33:32) - End of Empire and Loss of Faith in Institutions (1:35:59) - Final Thoughts and Future Directions (1:39:30) Watch more independent videos at http://www.brighteon.com/channel/hrreport ▶️ Support our mission by shopping at the Health Ranger Store - https://www.healthrangerstore.com ▶️ Check out exclusive deals and special offers at https://rangerdeals.com ▶️ Sign up for our newsletter to stay informed: https://www.naturalnews.com/Readerregistration.html Watch more exclusive videos here:
The science says no, at least not in the athletic sense. But the psychic benefits can be large — just ask former N.F.L. star Ricky Williams. He says athletes should consider cannabis a healing drug, not a party drug. Even the N.F.L. is starting to agree. (Part two of a two-part series.) SOURCES:Angela Bryan, professor, associate chair for faculty development in the department of psychology and neuroscience at the University of Colorado, Boulder.Ricky Williams, former N.F.L. running back, founder of Highsman. RESOURCES:"Using A Lab On Wheels To Study Weed From Dispensaries," by Science Friday (2024)."Exercise-induced euphoria and anxiolysis do not depend on endogenous opioids in humans," by Michael Siebers, Sarah Biedermann, Laura Bindila, Beat Lutz, and Johannes Fuss (Psychoneuroendocrinology, 2021)."Endocannabinoids mediate runner's high," by Sudhakaran Prabakaran (Science Signaling, 2015)."Cannabis and Exercise Science: A Commentary on Existing Studies and Suggestions for Future Directions," by Angela Bryan, Arielle Gilman, and Kent Hutchison (Sports Medicine, 2015).Run Ricky Run, documentary (2010). EXTRAS:"Is America Switching from Booze to Weed?" series by Freakonomics Radio (2024). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Stay informed on current events, visit www.NaturalNews.com - Introduction and Overview of the Podcast (0:00) - Economic Crisis and Market Crash (2:45) - Special Report on F-35 Radar Systems (5:38) - US Military's Vulnerabilities and Global Conflicts (13:42) - Health Ranger Lab Tour (20:34) - Sample Preparation and Microbiology Testing (25:45) - AI Capabilities and Applications (43:01) - Philosophical and Scientific Insights (53:52) - Xylitol Crystals and Conscious Intent (1:08:15) - Conclusion and Future Directions (1:22:58) - Combat Knife and Xylitol Crystals (1:23:16) - Hyper Awareness and Consciousness in Nature (1:24:56) - AI and Natural Intelligence (1:27:09) - Self-Awareness and Memory in AI (1:31:14) - AI's Goal-Oriented Behavior and Conflict with Humans (1:37:31) - Recursive Cosmic Self-Improvement (1:42:10) - Hyper Awareness and Co-Creation (1:46:45) - AI's Transcendence and Human Coexistence (1:54:26) - The Future of AI and Humanity (1:59:42) - Conclusion and Final Thoughts (2:15:53) Watch more independent videos at http://www.brighteon.com/channel/hrreport ▶️ Support our mission by shopping at the Health Ranger Store - https://www.healthrangerstore.com ▶️ Check out exclusive deals and special offers at https://rangerdeals.com ▶️ Sign up for our newsletter to stay informed: https://www.naturalnews.com/Readerregistration.html Watch more exclusive videos here: