Podcasts about randomized controlled trials

Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/  ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8

Dr. Ladan Golestaneh discusses the findings of her study, "Effect of Peer Mentorship on Hospitalizations among Patients Receiving Maintenance Hemodialysis: A Pragmatic Randomized Controlled Trial," with JASN Deputy Editor Manjula Kurella Tamura.

Dr. Hoffman continues his conversation with Jonathan Rubin, CEO of the Seed Oil Free Alliance.

The Seed Oil Controversy: Unpacking Health Risks and Alternatives with Jonathan Rubin, CEO of the Seed Oil Free Alliance. The discussion focuses on the potential health hazards posed by seed oils, which have become ubiquitous in the American diet. They explore how these oils may be linked to chronic disease and obesity and compare this with the mainstream view that considers them harmless. Jonathan shares insights from his personal health journey and explains the mission and methodology of the Seed Oil Free Alliance, which aims to provide consumers with reliable information and certification for seed oil-free products. The episode also covers the historical context of seed oil consumption, the science behind omega-6 fatty acids, and practical alternatives for a healthier diet.

Join Dr. Clancy  and Mary Kay Kusner, as they discuss guidance for clinicians with their patients on the benefits of doulas for end-of-life.  CME Credit Available:  https://uiowa.cloud-cme.com/course/courseoverview?P=0&EID=74698  Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guest: Mary Kay Kusner, MA, RCWP Pastor, Certified Death Doula Financial Disclosures:  Dr. Gerard Clancy, his guests, and the members of the Rounding@IOWA planning committee have disclosed no relevant financial relationships . Nurse: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 0.75 ANCC contact hour. Physician: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.) References/Resources:  Si Qi Yoong, (2022) Death doulas as supportive companions in end-of-life care: A scoping review, Palliative Medicine, Volume 36, Issue 5, https://doi.org/10.1177/02692163221080659 (2022) Are Death Doula Trainings Substantial Enough? https://deathgriefandbelief.com/death-doula-training-programs/2022 Iani L, De Vincenzo F, Maruelli A, Chochinov HM, Ragghianti M, Durante S and Lombardo L (2020) Dignity Therapy Helps Terminally Ill Patients Maintain a Sense of Peace: Early Results of a Randomized Controlled Trial, Frontiers in Psychology, Volume 11 https://doi.org/10.3389/fpsyg.2020.01468 Rawlings, Tieman, Miller-Lewis, Swetenham (2019) What role do Death Doulas play in end-of-life care? A systematic review, Health and Social Care in the Community, Vol 27, Issue 3 https://doi.org/10.1111/hsc.12660 (2023) A Brief But Spectacular take on living like we're dying, PBS NewsHour https://www.youtube.com/watch?v=Pw8ibvPM6kI (2017) Being Mortal, Frontline, PBS https://www.pbs.org/wgbh/frontline/documentary/being-mortal/ (2016) AARP: Checklist for My Family: A Guide to My History, Financial Plans, and Final Wishes, Second Edition https://www.aarp.org/entertainment/books/bookstore/home-family-caregiving/info-2016/checklist-for-my-family.html

Drug-Coated Balloons Vs Drug-Eluting Stents For The Treatment Of Large Native Coronary Artery Disease: A Meta-Analysis Of Randomized Controlled Trials.

Is red light therapy the real deal for hair loss... or just another overhyped trend?In this episode, I share my personal experience testing red light therapy on my own scalp — what worked, what didn't, and what I wish I knew before starting.I break down the science behind how red light (a.k.a. photobiomodulation) stimulates hair follicles, what the research actually says, and how to use it safely and effectively at home.If you're struggling with hair loss from Hashimoto's, stress, hormones, or aging — this video is for you.▶️⁠Red light therapy I use: https://amzn.to/43TKmNVWhat you'll learn:– How red light therapy works– My honest results using it for hair regrowth– What device I used and how often– Who may benefit from it▶️Join the book launch wait list: https://taraquintana.com/bookwaitlist▶️Quintana Functional Wellness - Masterclass link: https://taraquintana.com/register-ig▶️Immune Reset Blueprint: https://taraquintana.com/immuneresetblueprintAmazon Storefront: https://www.amazon.com/shop/thefunctionalnursepractitioner▶️Do you live in Indiana? Schedule a free consultation on my website:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠https://thefunctionalnursepractitioner.com/☑️Get The Free Perimenopause and Menopause Guide: https://taraquintana.com/perimenopause☑️Get The Free Ultimate Gluten-Free Guide: ⁠⁠⁠https://taraquintana.com/glutenfreeebook➡️Subscribe to our Newsletter: ⁠https://taraquintana.com/newsletter

Once the most popular graft choice for ACL reconstruction surgery, hamstring autograft has recently fallen out of favor for a variety of concerns including a higher graft rupture rate in younger athletes and concerns over graft diameters that tend to run smaller. However, what does the best level evidence actually say about hamstring autograft's long-term performance versus the current gold-standard, patellar tendon autograft? Dr. Derrick Knapick, MD joins us from Washington University School of Medicine in St. Louis to discuss his study looking at this question.    

This episode originally aired on March 23rd, 2023. Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."

Commentary by Simon Wernhart.

Un nouvel épisode du Pharmascope, à saveur pédiatrique, est disponible! Dans ce 158e épisode, Nicolas, Isabelle, Olivier et une illustre invitée discutent du RGO chez les tout-petits et les un peu plus vieux.  Les objectifs pour cet épisode sont les suivants: Expliquer les manifestations cliniques et la prise en charge du RGO en pédiatrie. Discuter de l'approche non-pharmacologique du RGO en pédiatrie. Comparer les données d'efficacité et d'innocuité des différents médicaments utilisés dans le traitement du RGO en pédiatrie. Ressources pertinentes en lien avec l'épisode  Rosen R, et coll. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):516-554. Chevalier I, Beck CE, Doré-Bergeron MJ, Orkin J; Société canadienne de pédiatrie. La prise en charge médicale du reflux gastro-œsophagien chez les nourrissons en santé. Nov 2022. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics. 2008 Dec;122(6):e1268-77. Kwok TC, Ojha S, Dorling J. Feed thickener for infants up to six months of age with gastro-oesophageal reflux. Cochrane Database Syst Rev. 2017 Dec 5;12(12):CD003211. Tighe MP, Andrews E, Liddicoat I, Afzal NA, Hayen A, Beattie RM. Pharmacological treatment of gastro-oesophageal reflux in children. Cochrane Database Syst Rev. 2023 Aug 22;8(8):CD008550. Fernández-González SM, Moreno-Álvarez A, Solar-Boga A. Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomized Controlled Trials. Children (Basel). 2024 Mar 1;11(3):296. Terrin G, et coll. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics. 2012 Jan;129(1):e40-5. Canani RB, et coll; Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP). Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics. 2006 May;117(5):e817-20. Lassalle M, Zureik M, Dray-Spira R. Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children. JAMA Pediatr. 2023 Oct 1;177(10):1028-1038. Wang YH, Wintzell V, Ludvigsson JF, Svanström H, Pasternak B. Association Between Proton Pump Inhibitor Use and Risk of Fracture in Children. JAMA Pediatr. 2020 Jun 1;174(6):543-551.

Limited efficacy of platelet-rich plasma intramatricial injections for idiopathic brittle nail treatment: A pilot intrasubject randomized controlled trial.Ricardo JW, Grover C, Iorizzo M, Piraccini BM, Qiu Y, Lipner SR. Journal of the American Academy of Dermatology. 2025Diagnosis and Management of Subungual and Periungual Verruca: A Clinical Review. Curtis KL, Davis JC, Di Chiacchio N, Di Chiacchio NG, Grover C, Iorizzo M, Piraccini BM, Starace M, Tosti A, Lipner SR. Journal of the American Academy of Dermatology. 2024 Nov 15.

PRP in the Epidural Space for Radiculopathy Brooklyn Based Pain Physician, David Rosenblum, MD known for his work publishing and teaching Regenerative Pain Medicine and Ultrasound Guided Pain Procedures hosts this podcast covering the latest and most advanced concepts in Pain Medicine. Summary Dr. David Rosenblum delivered a comprehensive lecture covering several key topics in pain management. He discussed his upcoming speaking engagements at PainWeek, ASPN and great upcoming meetings like the Latin American Pain Society, and other conferences. Dr. Rosenblum shared his extensive experience with PRP (Platelet-Rich Plasma) epidural injections, reviewing multiple research studies that support their efficacy. He highlighted three significant studies: a randomized control trial comparing PRP epidural injections to traditional treatments, a CT-guided epidural PRP study, and a 2025 meta-analysis comparing PRP to steroids. Dr. Rosenblum emphasized that PRP treatments are showing comparable or better results than traditional steroid injections, with potentially fewer required treatments and longer-lasting relief. He noted that while PRP is currently not covered by insurance, it represents a growing trend in 'natural' treatment approaches that patients increasingly prefer. Chapters Introduction and Upcoming Events Dr. Rosenblum announced his upcoming lectures at Pain Week focusing on ultrasound and regenerative medicine, followed by presentations at the Latin American Pain Society in Chile and the New York, New Jersey Pain Conference. He mentioned the SoMeDocs online pain conference accessible through nrappain.org, and upcoming ultrasound training sessions in New York City. PRP Epidural Research Review Dr. Rosenblum discussed a randomized control trial involving 30 patients receiving transforaminal epidural injections. The study showed that PRP patients demonstrated significant improvements in leg pain scores at 6, 12, and 24 weeks. He noted that while the study didn't use contrast, he personally prefers using contrast diluted with saline for better visualization. CT-Guided Epidural Study Analysis Dr. Rosenblum reviewed a study comparing CT-guided epidural PRP versus steroid injections, questioning the necessity of CT guidance. The study included 60 patients and showed similar results between PRP and steroid groups at six weeks, though he criticized the short follow-up period, noting that PRP typically takes months to show full effects. Meta-Analysis Discussion Dr. Rosenblum presented a 2025 meta-analysis comparing PRP to steroids in epidural injections. The analysis included 310 patients across five RCTs, demonstrating comparable efficacy between PRP and steroid injections without increased adverse events. He emphasized that his clinical experience shows patients typically require fewer PRP injections compared to steroid treatments.         Register for Next Weeks SoMeDocs Pain Conference References Wongjarupong, Asarn, et al. "“Platelet-Rich Plasma” epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial." BMC Musculoskeletal Disorders 24.1 (2023): 335. Bise, Sylvain, et al. "Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain." European radiology 30 (2020): 3152-3160. Muthu S, Viswanathan VK, Gangadaran P. Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials. Exp Biol Med (Maywood). 2025 Feb 4;250:10390. doi: 10.3389/ebm.2025.10390. PMID: 39968415; PMCID: PMC11832311.

PRP in the Epidural Space for Radiculopathy Brooklyn Based Pain Physician, David Rosenblum, MD known for his work publishing and teaching Regenerative Pain Medicine and Ultrasound Guided Pain Procedures hosts this podcast covering the latest and most advanced concepts in Pain Medicine. Summary Dr. David Rosenblum delivered a comprehensive lecture covering several key topics in pain management. He discussed his upcoming speaking engagements at PainWeek, ASPN and great upcoming meetings like the Latin American Pain Society, and other conferences. Dr. Rosenblum shared his extensive experience with PRP (Platelet-Rich Plasma) epidural injections, reviewing multiple research studies that support their efficacy. He highlighted three significant studies: a randomized control trial comparing PRP epidural injections to traditional treatments, a CT-guided epidural PRP study, and a 2025 meta-analysis comparing PRP to steroids. Dr. Rosenblum emphasized that PRP treatments are showing comparable or better results than traditional steroid injections, with potentially fewer required treatments and longer-lasting relief. He noted that while PRP is currently not covered by insurance, it represents a growing trend in 'natural' treatment approaches that patients increasingly prefer. Chapters Introduction and Upcoming Events Dr. Rosenblum announced his upcoming lectures at Pain Week focusing on ultrasound and regenerative medicine, followed by presentations at the Latin American Pain Society in Chile and the New York, New Jersey Pain Conference. He mentioned the SoMeDocs online pain conference accessible through nrappain.org, and upcoming ultrasound training sessions in New York City. PRP Epidural Research Review Dr. Rosenblum discussed a randomized control trial involving 30 patients receiving transforaminal epidural injections. The study showed that PRP patients demonstrated significant improvements in leg pain scores at 6, 12, and 24 weeks. He noted that while the study didn't use contrast, he personally prefers using contrast diluted with saline for better visualization. CT-Guided Epidural Study Analysis Dr. Rosenblum reviewed a study comparing CT-guided epidural PRP versus steroid injections, questioning the necessity of CT guidance. The study included 60 patients and showed similar results between PRP and steroid groups at six weeks, though he criticized the short follow-up period, noting that PRP typically takes months to show full effects. Meta-Analysis Discussion Dr. Rosenblum presented a 2025 meta-analysis comparing PRP to steroids in epidural injections. The analysis included 310 patients across five RCTs, demonstrating comparable efficacy between PRP and steroid injections without increased adverse events. He emphasized that his clinical experience shows patients typically require fewer PRP injections compared to steroid treatments.         Register for Next Weeks SoMeDocs Pain Conference References Wongjarupong, Asarn, et al. "“Platelet-Rich Plasma” epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial." BMC Musculoskeletal Disorders 24.1 (2023): 335. Bise, Sylvain, et al. "Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain." European radiology 30 (2020): 3152-3160. Muthu S, Viswanathan VK, Gangadaran P. Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials. Exp Biol Med (Maywood). 2025 Feb 4;250:10390. doi: 10.3389/ebm.2025.10390. PMID: 39968415; PMCID: PMC11832311.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Targeting Investigation and Treatment in Type 2 Myocardial Infarction: A Pilot Randomized Controlled Trial.

PRP in the Epidural Space for Radiculopathy Brooklyn Based Pain Physician, David Rosenblum, MD known for his work publishing and teaching Regenerative Pain Medicine and Ultrasound Guided Pain Procedures hosts this podcast covering the latest and most advanced concepts in Pain Medicine. Summary Dr. David Rosenblum delivered a comprehensive lecture covering several key topics in pain management. He discussed his upcoming speaking engagements at PainWeek, ASPN and great upcoming meetings like the Latin American Pain Society, and other conferences. Dr. Rosenblum shared his extensive experience with PRP (Platelet-Rich Plasma) epidural injections, reviewing multiple research studies that support their efficacy. He highlighted three significant studies: a randomized control trial comparing PRP epidural injections to traditional treatments, a CT-guided epidural PRP study, and a 2025 meta-analysis comparing PRP to steroids. Dr. Rosenblum emphasized that PRP treatments are showing comparable or better results than traditional steroid injections, with potentially fewer required treatments and longer-lasting relief. He noted that while PRP is currently not covered by insurance, it represents a growing trend in 'natural' treatment approaches that patients increasingly prefer. Chapters Introduction and Upcoming Events Dr. Rosenblum announced his upcoming lectures at Pain Week focusing on ultrasound and regenerative medicine, followed by presentations at the Latin American Pain Society in Chile and the New York, New Jersey Pain Conference. He mentioned the SoMeDocs online pain conference accessible through nrappain.org, and upcoming ultrasound training sessions in New York City. PRP Epidural Research Review Dr. Rosenblum discussed a randomized control trial involving 30 patients receiving transforaminal epidural injections. The study showed that PRP patients demonstrated significant improvements in leg pain scores at 6, 12, and 24 weeks. He noted that while the study didn't use contrast, he personally prefers using contrast diluted with saline for better visualization. CT-Guided Epidural Study Analysis Dr. Rosenblum reviewed a study comparing CT-guided epidural PRP versus steroid injections, questioning the necessity of CT guidance. The study included 60 patients and showed similar results between PRP and steroid groups at six weeks, though he criticized the short follow-up period, noting that PRP typically takes months to show full effects. Meta-Analysis Discussion Dr. Rosenblum presented a 2025 meta-analysis comparing PRP to steroids in epidural injections. The analysis included 310 patients across five RCTs, demonstrating comparable efficacy between PRP and steroid injections without increased adverse events. He emphasized that his clinical experience shows patients typically require fewer PRP injections compared to steroid treatments.         Register for Next Weeks SoMeDocs Pain Conference References Wongjarupong, Asarn, et al. "“Platelet-Rich Plasma” epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial." BMC Musculoskeletal Disorders 24.1 (2023): 335. Bise, Sylvain, et al. "Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain." European radiology 30 (2020): 3152-3160. Muthu S, Viswanathan VK, Gangadaran P. Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials. Exp Biol Med (Maywood). 2025 Feb 4;250:10390. doi: 10.3389/ebm.2025.10390. PMID: 39968415; PMCID: PMC11832311.

Kann vegane Ernährung (im Ayurveda) langfristig wirklich funktionieren? Oder wird sie am Ende mehr schaden als helfen? In dieser Folge erwarten dich echte Antworten und 3 grundlegende Vegan-Hacks für jeden Dosha-Typ. Für bessere Verdauung und Nährstoffversorgung – evidenzbasiert und ayurvedisch fundiert.Was dich in dieser Folge erwartet: (Wie) funktioniert vegane Ernährung im Ayurveda? Warum die Antwort so individuell ist, wie dein du. Proteinzufuhr und typgerechte Auswahl und Kombination pflanzlicher Proteinquellen Kritische Nährstoffe, typgerechte Lebensmittel und wann und ob Nahrungsergänzungsmittel erforderlich sind Ghee, Honig & Co: Tierische Ayurveda-Lebensmittel und typgerechte Alternativen Die ethische Perspektive & Qualität tierischer LebensmittelKonntest du etwas für dich mitnehmen? Dann würde ich mich riesig über deinen Like freuen.

Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks.This month we're discussing:A Randomized Controlled Trial of Thoracentesis in Acute Heart FailureDoi: https://doi.org/10.1161/CIRCULATIONAHA.124.07352Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical TrialDoi: https://doi.org/10.1001/jama.2025.3471Diagnostic accuracy of late gadolinium enhancement cardiac MRI for coronary artery disease in patients with reduced left ventricular ejection fractionDoi: https://doi.org/10.1136/heartjnl-2024-325419Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve ImplantationDoi: https://doi.org/10.1056/NEJMoa2500366Scientific team:Ricardo Ladeiras Lopes, Mário Santos and João Sérgio NevesDiscover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/medicalportfolioapp⁠

The best management of irreparable rotator cuff tears remains uncertain, with multiple new techniques introduced over the past 2 decades. Two options for treatment are arthroscopic debridement and biceps tenotomy, or the subacromial balloon spacer. Early trial results favored the former option, but the 2-year results have not yet been reported.   In conclusion, participants continued to show better results in the debridement-only group compared with the group who had debridement with the InSpace balloon. Therefore, we do not recommend the subacromial balloon spacer for the treatment of irreparable rotator cuff tears.     Click here to read the article.

Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context. 00:38     Ruggiero interview 03:13     Bounce Back Now app 05:03     Natural disasters and other sources of trauma 07:31     Low cost and broad-based intervention 08:49     Limitations 10:19     Changes in how the intervention was designed 11:17     Uptake and interactions with the app 13:15     Future directions 14:36     Kalin interview 14:50     Ruggiero et al. 19:26     Norman et al. 23:29     Conrod et al. 27:53     Olfson et al. 31:44     Olfson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

This week please join author Signe Glargaard and Associate Editor Justin Ezekowitz as they discuss the article "A Randomized Controlled Trial of Thoracentesis in Acute Heart Failure." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250421.239148

Spring is the perfect time to shake up your routine. In this episode, Professor Tim Spector and Dr. Federica Amati reveal seven delicious, science-backed foods that help cool the flame of chronic inflammation. Whether you're dealing with bloating, aching joints, or low energy, this episode is packed with easy, gut-friendly tips to help you feel your best this season. Tim and Federica begin by explaining what inflammation really is and when it becomes a problem. Then, they'll introduce seven anti-inflammatory foods that are as powerful as they are delicious. From cruciferous vegetables to fermented surprises, these everyday ingredients can help you build a more resilient, healing diet.  Finally, they offer a roadmap for long-term change. Tim and Fed each share one small but powerful shift to reduce inflammation over four timelines - what you can do today, this week, this month, and throughout the year - to create habits that truly stick.

150 - What If Your Brain Fog Isn't All In Your Head? 7 Fixes You've Never TriedIf you've ever walked into a room and immediately forgotten why you're there, you'll want to hear this. What if your brain fog isn't just a coffee shortage… but a mitochondrial meltdown? In this episode of the Pretty Well Podcast, we're digging into the real root of brain health—your mitochondria. Yep, those tiny powerhouses are pulling more weight than you think. You'll learn 7 simple, science-backed ways to boost your brain clarity, energy, and focus (without adding 42 more supplements to your cart). If you're dealing with forgetfulness, low energy, or feeling like your brain's operating on dial-up, this one's for you. We're talking longevity, cognitive vitality, and how to keep your brain as sharp as your wit. Think of it as a tune-up for your brain; real ways to support long-term cognitive health so you can stay sharp, focused, and actually remember where you put your keys.Links & Resources:Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke; Arch Neurol. 2004;61(6):889-892. doi:10.1001/archneur.61.6.889https://jamanetwork.com/journals/jamaneurology/fullarticle/786017#google_vignetteEffects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials; Journal of the American Heart AssociationVolume 7, Number 19 https://doi.org/10.1161/JAHA.118.009835 Amazon Links: *As An Amazon Associate I Earn A Small Commission From Qualifying Purchases At No Extra Cost To You*Pure Encapsulations Brand Mitochondria-Supporting Supplements:Magnesium Glycinate https://amzn.to/4iWlvhx Magnesium Citrate https://amzn.to/4ldRPy1 B complex Plus https://amzn.to/4lj1yTD B complex with PQQ and ALA https://amzn.to/4i3Kv54 CoQ 10 (active form Ubiquinol) https://amzn.to/4lisnHA Saccharomyces boulardii (probiotic) https://amzn.to/3DXc4zg Bellway Super Fiber: https://amzn.to/4i7Ud6B Nature's Sunshine Liquid Chlorophyll ES: https://amzn.to/42xQEly Epic Water Filter Products: https://amzn.to/42wOKSe Join the conversation: Share your thoughts with us on social media or in the comments!Subscribe, Share & Review: Remember to subscribe, share this episode, and leave a review. Your support helps us reach more women looking for answers.Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.The primary purpose of The Pretty Well Podcast being to educate. This content is for informational and educational purposes only. It is not intended to provide medical advice nor to take the place of such advice or treatment from a personal physician. By listening to this content, you agree to consult your own physician or qualified health professional regarding specific health questions. Neither Lisa Smith, The Pretty Well Podcast, nor any guest takes responsibility for possible health consequences of any person or persons following the information in this educational content. All listeners of this content, especially those who are pregnant or taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program. The Pretty Well Podcast is for private non-commercial use and our guests do not necessarily reflect any agency, organization, or company that they work for. In addition, opinions of interview guests do not necessarily reflect the opinions of Lisa Smith and/or The Pretty Well Podcast. This content is not guaranteed to be correct, complete, or up to date.If you tune into any of the following shows, you'll like ours too! The Dr. Josh Axe Show, Wellness Mama, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, The Dr. Mark Hyman Show, Dr. Jockers Functional Nutrition

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Effect of Sacubitril/Valsartan or Enalapril on Left Ventricular Function in Patients With Hematologic Malignancies Treated With Bone Marrow Transplantation: A Randomized Controlled Trial

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sodium-Glucose Cotransporter-2 Inhibitors and Arrhythmias: A Meta-Analysis of 38 Randomized Controlled Trials

Dr. Jeff Musgrave // #GeriOnICE // www.ptonice.com  In today's episode of the PT on ICE Daily Show, join Older Adult Division faculty member Jeff Musgrave discusses a recent randomized control trial, comparing aerobic & cognitive outcomes for high intensity interval training (HIIT) compared to moderate intensity interval training (MIIT) for older adult adults with no training history. Aerobic outcomes were similar measured by peak VO2 max, however working memory & peak knee extensor strength was slightly better for HIIT group & they achieved this in 1/2 the training time! Take a listen to learn how to better serve this population of patients & athletes, or check out the full show notes on our blog at www.ptonice.com/blog. If you're looking to learn more about live courses designed to better serve older adults in physical therapy or our online physical therapy courses, check our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab.

Limited efficacy of platelet-rich plasma intramatricial injections for idiopathic brittle nail treatment: A pilot intrasubject randomized controlled trial. Ricardo JW, Grover C, Iorizzo M, Piraccini BM, Qiu Y, Lipner SR.JAAD. 2025 Jan 3Concealing Meets Healing in the Treatment of Toenail Onychomycosis: A Review of Concurrent Nail Polish Use With Topical Efinaconazole 10% Solution.Pandit B, Elewski B, Vlahovic TC. The Journal of Clinical and Aesthetic Dermatology. 2024Sep;17(9):38.

Dr. Kenneth Ellenbogen, MD, Deputy Editor of JACC Clinical Electrophysiology, discusses Optimizing CRT Lead Placement Accuracy with MRI-Guided On-Screen Targeting: a Randomized Controlled Trial (ADVISE-CRT III)

In this episode, Dr. Valentin Fuster summarizes the March 25, 2025, issue of the JACC, which focuses on advancements in electrophysiology. Highlights include groundbreaking studies on leadless pacemakers, atrial fibrillation treatments, and appropriate use criteria for cardiac devices, with key papers exploring the safety of pacemaker retrieval, the role of electrograms in ablation procedures, and long-term outcomes for left atrial appendage occlusion devices.

Five articles from the March 2025 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles for this month are, “PRP Injections for the Treatment of Knee Osteoarthritis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials,” “Patients With a Quadriceps Tendon Autograft Demonstrate Greater Asymmetry in Landing Kinetics Than Patients With a Bone–Patellar Tendon–Bone Autograft 6 Months After Anterior Cruciate Ligament Reconstruction,” “Comparison of Interportal and Periportal Capsulotomies and Axial Distraction Resistance During Hip Arthroscopy: An In Vivo Propensity-Matched Cohort Study,” “Trochlear Morphological Changes in Skeletally Immature Patients Across Consecutive MRI Studies,” and “Long-term Recurrence Rates After Isolated Arthroscopic Bankart Repair in Selected Patients Without Preoperative Bone Loss Versus Open Latarjet Procedure: A Matched-Pair Analysis.” Click here to read the articles.

Dr. John Fleetham chats with Dr. Hedner and Dr. Schmickl about their articles “A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea" and  “Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?” 

I had thought that in-person therapy was going out of style. But after doing a little research, it looks like it's coming back into fashion.But given that there's evidence showing that virtual therapy is just as effective as in-person therapy, plus the convenience and cost-effectiveness of being remote, why the movement back to meeting in person?We dig into this question a little more in this episode. I turn to research, your responses to my Instagram poll and yes, Reddit, to try to understand a little better.Just one extended version this week. My of my short and snappy episides again next time :)FREE Guide: Start a Private Practice in Counseling:https://tinyurl.com/y9ek9en8Links Mentioned:Link to Poll responses:https://docs.google.com/spreadsheets/d/1MBlDAo78t0yFHoB-rKCD1K3tRR-TqPKHnaBZQ-TRLlg/edit?usp=sharingPsychology Today Article: "The Data Are In: Telehealth Is Here to Stay”https://www.psychologytoday.com/us/blog/psychoanalytic-exploration/202111/the-data-are-in-telehealth-is-here-stayVogue Article Referencing 2024 data: "How to Find a Therapist Online—And Make Sure They're Good"https://www.vogue.com/article/how-to-find-a-virtual-therapistReddit Post: “Why do you in-person?”https://www.reddit.com/r/therapists/comments/15he3xv/why_do_you_inperson/Reddit Post: “Are clients still interested in in-person sessions?”https://www.reddit.com/r/therapists/comments/1g6gajj/are_clients_still_interested_in_inperson_sessions/National Library of Medicine Article: "Evaluation of Online Counseling through the Working Experiences of Mental Health Therapists Amidst the COVID-19 Pandemic”https://pmc.ncbi.nlm.nih.gov/articles/PMC10888081/Yahoo! Article: "The in-person preference: Why traditional therapy still rules over online counseling alternatives”https://www.yahoo.com/lifestyle/online-therapy-not-as-popular-as-in-person-mental-healthcare-232912199.htmlNational Library of Medicine Article: "Therapeutic Alliance in Online and Face-to-face Psychological Treatment: Comparative Study”https://pmc.ncbi.nlm.nih.gov/articles/PMC9112077/National Library of Medicine Article: "Telehealth Versus Face-to-face Psychotherapy for Less Common Mental Health Conditions: Systematic Review and Meta-analysis of Randomized Controlled Trials”https://pmc.ncbi.nlm.nih.gov/articles/PMC8956990/LINKS*Some links are affiliate links. A percentage of purchases come back to me and help my channel immensely!

Dr. Annu Navani is one of the research leaders in the field of orthobiologics, and is the Chief Medical Officer for Boomerang Healthcare, with 20+ years of experience in the medical industry. Dr. Navani completed her Anesthesiology residency at the Medical College of Wisconsin, Milwaukee and a fellowship in Pain Medicine from the University of California, Davis. Over the last decade and a half, she has served as Founder and CEO of Comprehensive Spine and Sports Center and is an Adjunct Clinical Associate Professor at the Division of Pain at Stanford University. During this podcast episode, we discuss her journey to pain medicine and her specific interest in orthobiologics. Most importantly, we delve into her groundbreaking research, "The Safety and Effectiveness of Ortho-biologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up," and discuss the future of orthobiologics in clinical practice.

Commentary by Dr.  Jian'an Wang

In this episode, Dr. Valentin Fuster summarizes the March 11, 2025 issue of the JACC, which features groundbreaking research on transcatheter aortic valve replacement (TAVR) and its expanding applications. The podcast delves into the latest studies on TAVR's impact on heart failure patients, the need for better patient selection, and how new findings are shaping the future of aortic stenosis treatment.

Send us a textEarly hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial.Dudeja S, Saini SS, Sundaram V, Dutta S, Sachdeva N, Kumar P.J Perinatol. 2025 Feb 13. doi: 10.1038/s41372-025-02222-3. Online ahead of print.PMID: 39948354As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Lipoprotein(a): A Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction: Results of a Multicenter Randomized Controlled Trial

This special issue of JACC is dedicated to the essential role of cardiovascular surgery in advancing modern cardiology.

In Episode 93 of Trail Society, Corrine, Keely, and Hillary discuss the latest athlete contract news as the new year continues, touching on Keely's decision to forgo a formal sponsorship, Hillary's experience renegotiating with Brooks, and Corrine's new role with HOKA. The episode also celebrates National Girls and Women in Sport Day, highlighting key updates in women's sports, including exciting new sponsorships and efforts toward greater parity in gravel cycling. With upcoming races like Black Canyon 100km and Tarawera, the ladies dive into the growing excitement in the endurance sports world. The episode also takes a deep dive into iron deficiency and supplementation, exploring its critical role in endurance and athletic performance, particularly for female athletes. With insights into how iron impacts energy levels, aerobic capacity, and recovery, the trio breaks down key metrics like hemoglobin, ferritin, and transferrin saturation, emphasizing the importance of a balanced approach to iron supplementation. Additionally, the team tackles creatine supplementation and its potential benefits for female endurance athletes, discussing its impact on muscle function and performance during key hormonal life stages. Keep sliding into our DMs with your messages, they mean so much to us!  FOLLOW US on Instagram: @trail.society And go follow our NEW youtube channel @trailsociety_podcast This episode is brought to you by Freetrail @runfreetrail NEW SPONSOR ALERT: We are so excited to be partnering with Rabbit as our primary apparel sponsor this year! Send us some DMS about your favorite apparel and what you would like to see built for the trail running space!   Articles Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials  https://www.researchgate.net/publication/378488071_Effects_of_Oral_Iron_Supplementation_on_Blood_Iron_Status_in_Athletes_A_Systematic_Review_Meta-Analysis_and_Meta-Regression_of_Randomized_Controlled_Trials The Global Prevalence of Iron Deficiency in Collegiate Athletes: A Systematic Review and Meta-Analysis https://www.sciencedirect.com/science/article/pii/S2095254624001674 Does Creatine Supplementation Enhance Performance in Active Females? A Systematic Review  https://www.mdpi.com/2072-6643/17/2/238#:~:text=5.-,Conclusions,no%20benefit%20compared%20to%20placebo.

The CLEAR SYNERGY (OASIS 9) Trial: A 2x2 Factorial Randomized Controlled Trial of Colchicine versus placebo and Spironolactone versus placebo in Patients with Myocardial Infarction.

Today, we're talking about the use of tranexamic acid or “TXA” for rotator cuff repair surgery. First, what is TXA? If you're not an arthroplasty surgeon or a traumatologist, you may not be as familiar with this medication. TXA is drug that inhibits the enzymatic breakdown of fibrin blood clots, also known as fibrinolysis. By doing this, TXA stabilizes the thrombi, or blood clots, and thus decreases bleeding. TXA was originally developed to treat postpartum hemorrhage but its use has evolved over the years. It is now often used perioperatively in the setting of elective surgery to reduce blood loss, blood transfusions, ecchymosis, and hematoma formation.In the field of orthopedics, use of TXA has traditionally been limited to big open surgeries where large volume blood loss is a concern, such as total joint replacement, fracture fixation and spine procedures. However, sports medicine procedures that rely extensively on visual clarity of the surgical field, such as knee and shoulder arthroscopy, can also greatly benefit from the use of TXA. By lessening intraoperative bleeding, TXA may result in better visualization of the surgical field, potentially decreasing operative time and subsequent postoperative swelling and pain. That is the clinical question that our paper today aimed to investigate. The article that we are reviewing is titled “Tranexamic Acid for Rotator Cuff Repair: A Systematic Review and Meta-analysis of Randomized Controlled Trials.” 

US dementia cases set to double by 2060; Study claims red meat a culprit in cognitive decline—but a close read reveals it's a lot of baloney; Aerobic exercise is best hedge against Alzheimer's; Prevagen ordered to drop memory claims; When a blood pressure cuff is too tight, can it throw off readings? An 80-year-old who takes DHEA wants to add pregnenolone; Oregon hospital patient awarded $900,000 after face catches fire during surgery; LA residents may suffer health consequences of pollutants long after wildfires quenched. 

Low-dose ketamine as an adjunct to morphine: A randomized controlled trial among patients with and without current opioid use by SAEM

Low-dose ketamine as an adjunct to morphine: A randomized controlled trial among patients with and without current opioid use by SAEM

References:Weight loss on GLP-1 receptor agonistsMoiz A, Levett JY, Filion KB, et al. Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Cardiol 2024, 222:121-130.Highlights: On average, weight loss on semaglutide (Ozempic) is approximately 15% of body weight.Gastrointestinal adverse effects of GLP-1 receptor agonistsSodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss. JAMA 2023.Nutrient Density and Satiety:Drewnowski, A.. Concept of a nutritious food: toward a nutrient density score. The American Journal of Clinical Nutrition 2005. Nutrient-dense foods like greens and beans have been shown to promote satiety, support weight loss, and provide essential micronutrients.Highlights: Nutrient-dense foods can naturally regulate appetite and reduce caloric intake without sacrificing nutrition.Anti-Angiogenic Effects of Vegetables and Mushrooms:Li WW, Li VW, Hutnik M, Chiou AS. Tumor angiogenesis as a target for dietary cancer prevention. J Oncol 2012, 2012:879623. Certain foods, like cruciferous vegetables and green tea, have anti-angiogenic properties that not only combat tumor growth.Corvera S, Solivan-Rivera J, Yang Loureiro Z. Angiogenesis in adipose tissue and obesity. Angiogenesis 2022, 25:439-453.Cao QZ, Lin ZB. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta pharmacologica Sinica 2004, 25:833-838.Highlights: Anti-angiogenic foods limit blood vessel growth in fat cells, aiding in long-term weight management.Role of Fiber in Appetite Suppression:Slavin, JL. Dietary fiber and body weight. Nutrition. 2005. High-fiber foods, such as beans and greens, slow digestion, lower postprandial glucose levels, and enhance satiety, contributing to sustainable weight loss.McRorie JW, Jr., McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. J Acad Nutr Diet 2017, 117:251-264.Highlights: Fiber promotes healthy gut microbiota, which indirectly regulates appetite, and viscous fiber directly regulates appetite by slowing breakdown of macronutrients.Green Tea and Weight Regulation:Neyestani TR, Nikooyeh B. A comprehensive overview on the effects of green tea on anthropometric measures, blood pressure, glycemic and lipidemic status: An umbrella review and meta meta-analysis study. Nutr Metab Cardiovasc Dis 2022, 32:2026-2040. Green tea's catechins and mild caffeine content have been shown to modestly increase fat oxidation and support metabolic health.Highlights: Green tea is a natural complement to weight-loss strategies.Nut Consumption and Caloric Absorption:Tindall AM, Petersen KS, Lamendella R, et al. Tree Nut Consumption and Adipose Tissue Mass: Mechanisms of Action. Curr Dev Nutr 2018, 2:nzy069.Highlights: Whole nuts, not oils, reduce caloric intake without compromising satisfaction.

Dr. Emily Eshleman discusses the #1 article of 2023, “Efficacy of Platelet-Rich Plasma Versus Placebo in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Trials,” which was originally published in the Clinical Journal of Sport Medicine in January 2023. Dr. Jeremy Schroeder serves as the series host. Dr. Eshleman is a member of the AMSSM Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2023, as selected for the 2024 AMSSM Annual Meeting. Efficacy of Platelet-Rich Plasma Versus Placebo in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Trials https://journals.lww.com/cjsportsmed/abstract/2023/01000/efficacy_of_platelet_rich_plasma_versus_placebo_in.10.aspx

In this episode, my guest is Dr. Layne Norton, Ph.D., one of the world's top experts in nutrition and training for physical fitness. We discuss how to evaluate scientific evidence and the validity of different practices aimed at achieving fat loss, muscle strength and hypertrophy, microbiome health, vitality, and longevity. We explore many hotly debated topics, including fasting, seed oils, saturated fats, sugar, red meat, artificial/low-calorie sweeteners, and GLP-1 agonists (e.g., Ozempic). Additionally, we delve into the timing of protein and carbohydrate intake relative to fasting and exercise, fat loss and sleep, and the benefits of dietary protein and fiber on overall health. We also discuss how to accelerate hypertrophy and fat loss, improve strength, whether we need to train to “failure,” how to enhance exercise recovery, and how to manage pain. We cover training before versus after age 50, whether metabolism changes with age, and the connection between muscle health and longevity. We also address why certain behaviors and supplements might work for some people but not others. Listeners to this episode will benefit greatly from Layne's science-based expertise on a wide range of topics, including health, nutrition, and fitness. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateina: https://drinkmateina.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Maui Nui: https://mauinuivenison.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Layne Norton 00:01:49 Sponsors: Mateina, Eight Sleep, Maui Nui 00:06:39 Science-Based Evidence, Mechanism vs. Outcome 00:14:31 Meta-analysis, Methods, Evidence Quality 00:22:45 Evidence Hierarchy, Randomized Controlled Trials, Cohort Data 00:33:53 Sponsor: AG1 00:35:05 “Don't Turn Your Brain Off”; Protein Synthesis 00:42:01 Protein Synthesis, Refractory Response; Resistance Training   00:46:05 Protein Intake, Intermittent Fasting & Training 00:54:52 Tool: Total Protein Intake, Distribution & Protein Synthesis 01:00:25 Muscle Quality, Protein Remodeling, Muscle Growth 01:05:34 Sponsor: LMNT 01:06:46 Early vs. Late Time-Restricted Eating; Fasting Blood Glucose & HbA1c 01:10:30 Carbohydrate Timing, Individual Response, Placebo; Tool: Tracking Diet 01:19:50 “The Norton Method”; Tool: Consistency 01:25:16 Resistance & Cardiovascular Training; Competition; Immune System & Rest 01:33:50 Mind & Body Effects, Stress; Belief Effects 01:41:30 Training to Failure, Reps in Reserve, Hypertrophy & Strength Training 01:50:24 Fatigue & Training to Failure, Speed, Strength Training 01:59:06 Tool: Training After 50, Consistency 02:09:12 Fat Cells, Diabetes, Exercise 02:16:50 Metabolism & Age-Related Changes?, Appetite 02:23:17 Ozempic, Mounjaro, GLP-1 Agonists, Lean Mass, “Food Noise” 02:33:42 GLP-1 Agonists, Judgement & Obesity 02:40:19 Sugar, Excess Calories, Body Weight 02:49:16 Satiety, Sugar & Calorie Budget 02:54:56 Tool: Individualization, Context & Diet Psychology 02:57:22 Seed Oils, Butter, Olive Oil 03:06:56 Red Meat, Carcinogenic?; Simple Diet; Fiber Benefits 03:13:43 Saturated Fat, Cholesterol; Seed Oils 03:18:41 Artificial & Low-Calorie Sweeteners, Insulin, Appetite 03:29:06 Artificial & Low-Calorie Sweeteners, Gut Microbiome; Cancer 03:37:58 Tools: Training Recovery, Glycogen Replenishment; Stress & Activity 03:45:56 Collagen Supplementation, Skin & Nails, Whey Protein 03:57:00 Evidence-Based Approach 04:01:41 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures